Affinage

PRDM1

PR domain zinc finger protein 1 · UniProt O75626

Length
825 aa
Mass
91.8 kDa
Annotated
2026-06-10
100 papers in source corpus 43 papers cited in narrative 43 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PRDM1/BLIMP1 is a sequence-specific zinc-finger transcription factor that serves as a master regulator of terminal effector differentiation across B cells, T cells, NK cells, dendritic cells, photoreceptors, primordial germ cells, neural progenitors, and trophoblasts (PMID:16565720, PMID:16954370, PMID:20110327, PMID:22987638, PMID:29713018, PMID:31806661). It recognizes its DNA target through the combined action of its first two C2H2 zinc fingers, which together are minimally sufficient for binding (PMID:1569931); this DNA-binding activity is essential for its biological function, as a DNA-binding-domain deletion abolishes its ability to maintain T cell homeostasis (PMID:16565720). BLIMP1 silences target genes by recruiting chromatin-modifying corepressors—Groucho/TLE family proteins through a defined minimal repression domain (PMID:9887105), HDAC complexes that deacetylate the c-myc promoter (PMID:10713181), and the H3K9 methyltransferase G9a, which it recruits to assemble silent chromatin only when in complex (PMID:14985713). Genome-wide occupancy mapping shows BLIMP1 binding is methylation-sensitive and that it frequently occupies promoters with overlapping BLIMP1/IRF motifs, where it competitively antagonizes IRF activators such as IRF1 to block interferon-driven programs including MHC class I antigen processing (PMID:20421211, PMID:26158850, PMID:18025207). Through these mechanisms it represses lineage-inappropriate and proliferative programs (c-myc, p53, Pax5, MHC class I, cytokine genes, Ki-67/PCNA) while in select contexts directly activating targets such as Il10 and SLAMF7, and acting through histone demethylases (Kdm4a, LSD1) to remodel target loci (PMID:10713181, PMID:17264218, PMID:16954370, PMID:26158850, PMID:20530581, PMID:28935958, PMID:31806661, PMID:31811020, PMID:26310579). BLIMP1 sits within layered feedback circuits: it is induced by NF-κB, the PERK arm of the UPR, IL-2, and IL-21/STAT3 signaling, is repressed at its own locus by PAX5 and by Bach2–HDAC3–NCoR corepressor complexes, and engages in reciprocal antagonism with BCL6 to govern effector-versus-follicular/memory cell-fate decisions (PMID:17682124, PMID:19737919, PMID:16708403, PMID:19608860, PMID:26786103, PMID:32399548, PMID:38969872). Its activity is further tuned by FBXO11-mediated degradation (PMID:24968003). In therapeutic settings, PRDM1 ablation in CAR-T cells enhances memory phenotype, persistence, and antitumor efficacy by increasing chromatin accessibility at memory loci (PMID:34861037, PMID:36350986).

Mechanistic history

Synthesis pass · year-by-year structured walk · 21 steps
  1. 1992 High

    Established how PRDM1 achieves sequence-specific DNA recognition, defining the molecular basis for its targeting to gene promoters.

    Evidence zinc-finger domain-swap mutagenesis and in vitro DNA-binding assays on the beta-interferon PRDI element

    PMID:1569931

    Open questions at the time
    • Did not address how the remaining zinc fingers contribute to genome-wide site selection
    • No structure of the protein–DNA complex
  2. 1999 High

    Showed that PRDM1 represses transcription actively rather than by passive occlusion, identifying its first corepressor effector arm.

    Evidence Gal4-fusion repression assays, GST pulldown mapping, and dominant-negative Groucho rescue of IFN-beta repression

    PMID:9887105

    Open questions at the time
    • Did not establish which endogenous targets depend on Groucho/TLE recruitment
    • Relationship to other corepressor arms unresolved
  3. 2000 High

    Identified HDAC recruitment and histone deacetylation as a mechanism by which BLIMP1 silences a key proliferative target gene.

    Evidence Co-IP of HDAC with Blimp-1, ChIP of H3 deacetylation at the c-myc promoter, and TSA inhibition

    PMID:10713181

    Open questions at the time
    • Did not define the specific HDAC isoform or complex
    • Generalization beyond c-myc not tested
  4. 2004 High

    Extended the corepressor repertoire to histone methylation, showing BLIMP1 nucleates silent chromatin via G9a-dependent H3 methylation.

    Evidence reciprocal Co-IP, ChIP, and G9a catalytic-mutant assays in U2OS cells

    PMID:14985713

    Open questions at the time
    • How G9a, HDAC, and Groucho arms are coordinated at individual loci is unresolved
    • Stoichiometry of the silencing complex unknown
  5. 2006 High

    Defined BLIMP1 as an essential, DNA-binding-dependent regulator of effector lymphocyte homeostasis and B-cell antibody secretion, establishing its in vivo physiological role.

    Evidence conditional and DNA-binding-domain-deletion mouse models with immunophenotyping, colitis transfer, cytokine and Ig-secretion assays

    PMID:16565720 PMID:16565721 PMID:16954370

    Open questions at the time
    • Direct target genes mediating each phenotype not fully mapped
    • Cell-intrinsic versus extrinsic contributions partly inferred
  6. 2006 Medium

    Connected BLIMP1 induction to stress and inflammatory signaling, placing it downstream of the PERK/UPR and NF-κB pathways.

    Evidence UPR chemical induction with PERK and NF-κB inhibition and transcriptional run-on assays in B and myeloid cells

    PMID:16708403

    Open questions at the time
    • Single-lab pharmacological dissection
    • Direct transcription factor binding at the Prdm1 locus not shown
  7. 2007 High

    Revealed autoregulatory and feedback loops linking BLIMP1 to p53 and PAX5, embedding it in cross-repressive transcriptional circuits.

    Evidence siRNA knockdown, promoter ChIP, p53-null rescue, EMSA, and promoter-mutant reporter assays

    PMID:17264218 PMID:17682124

    Open questions at the time
    • How these loops are biased toward one state in different lineages not resolved
    • Quantitative thresholds of the feedback not defined
  8. 2007 Medium

    Demonstrated context-dependent antagonism of IFN-γ-driven MHC class I antigen-processing genes by BLIMP1 competing with IRF activators.

    Evidence promoter reporter assays, surface MHC class I flow cytometry, and evolutionary ortholog comparison

    PMID:18025207

    Open questions at the time
    • Direct genomic occupancy shown only later
    • Single-lab reporter-based evidence
  9. 2009 High

    Placed BLIMP1 in the BCL6 binary switch governing effector versus follicular helper T cell fate and extended its repressive reach to myeloid NLR genes and the Prdm1 promoter architecture.

    Evidence reciprocal Bcl6/Blimp-1 conditional knockouts with immunization models, ChIP at the NLRP12 promoter, and targeted Prdm1 promoter/exon deletions testing NF-κB elements

    PMID:19234190 PMID:19608860 PMID:19737919

    Open questions at the time
    • Molecular basis of mutual BCL6/BLIMP1 antagonism at shared loci not fully resolved
    • Roles of the three alternative Prdm1 promoters across tissues incomplete
  10. 2010 High

    Mapped BLIMP1 genome-wide and showed methylation-sensitive, IRF-competitive binding, while extending its function to NK cytokine control and retinal photoreceptor fate stabilization.

    Evidence ChIP-seq with motif and CpG-methylation analysis plus knockdown transcriptomics; ChIP at IFNG/TNF loci in NK cells; retina-specific conditional knockout fate marker analysis

    PMID:20110327 PMID:20421211 PMID:20944005

    Open questions at the time
    • Determinants of activation versus repression at individual sites not predicted from motif alone
    • Lineage-specific cofactor identity at most occupied sites unknown
  11. 2012 Medium

    Established BLIMP1 as a tumor suppressor and proliferation repressor in NK cells and as a lineage driver of trophoblast giant cell differentiation.

    Evidence PRDM1 reconstitution with cell-cycle/apoptosis assays and MYC/4-1BBL target identification; trophoblast-specific knockout and Prdm1.Cre-LacZ lineage tracing

    PMID:22143801 PMID:22987638

    Open questions at the time
    • NK reconstitution from a single lab
    • Direct targets driving trophoblast differentiation not enumerated
  12. 2013 High

    Uncovered an indirect, microRNA-mediated mechanism (BLIMP1→let-7c→SOCS1) by which BLIMP1 restrains dendritic cell inflammatory output.

    Evidence DC-specific knockout, miRNA profiling, and let-7c gain/loss of function with cytokine and MHC II readouts

    PMID:23298838

    Open questions at the time
    • Whether BLIMP1 binds the let-7c locus directly not shown
    • Single-lab pathway
  13. 2014 Medium

    Identified FBXO11/DRE-1 as a post-translational regulator that binds BLIMP1 and promotes its degradation, conserved from C. elegans to human cells.

    Evidence C. elegans genetic epistasis and Co-IP of DRE-1/FBXO11 with BLMP-1 and human PRDI-BF1

    PMID:24968003

    Open questions at the time
    • Human degradation kinetics and physiological contexts not characterized
    • Cross-organism inference for the human interaction
  14. 2015 High

    Demonstrated direct chromatin-level repression of viral and host loci and revealed a bona fide trans-activating function, broadening the BLIMP1 mechanistic repertoire.

    Evidence ChIP at the HIV-1 ISRE with RNA Pol II and histone-acetylation readouts; ChIP-seq versus Irf1 in neonatal intestine; nuclear BLIMP1 localization downstream of VEGF/Erk/Stat3; EMSA/ChIP/promoter mutation at the CS1/SLAMF7 promoter

    PMID:25710909 PMID:26158850 PMID:26212250 PMID:26310579

    Open questions at the time
    • What distinguishes activated from repressed targets mechanistically unresolved
    • Cofactors required for trans-activation not identified
  15. 2016 High

    Defined the corepressor machinery that silences the Prdm1 locus itself, showing Bach2 assembles an HDAC3/NCoR/Rif1 complex at the gene.

    Evidence Co-IP/mass spectrometry of the Bach2 complex, ChIP at the Prdm1 intron 5 MARE, and HDAC3/NCoR1 knockdown

    PMID:26786103

    Open questions at the time
    • Signal that displaces Bach2 to de-repress Prdm1 not defined
    • Dynamics relative to NF-κB induction unresolved
  16. 2017 High

    Connected BLIMP1 to cancer cell proliferation control and metastatic plasticity, including direct repression of Ki-67/PCNA and hypoxia-driven metastatic programs.

    Evidence siRNA/overexpression with ChIP and promoter-mutation reporters in mantle cell lymphoma; PDAC mouse model with gain/loss of function and expression profiling under hypoxia

    PMID:20530581 PMID:28790031

    Open questions at the time
    • Context determining tumor-suppressive versus pro-metastatic roles unresolved
    • PDAC mechanism mapped at the program rather than target level
  17. 2018 Medium

    Resolved a division of labor with related factors and a core germline network, clarifying transient BLIMP1 action in effector T cells and its partnership with PAX5/OCT4 in germ cell specification.

    Evidence Blimp-1 conditional KO time-course in CD8/Trm cells; OCT4 ChIP-seq with PAX5 epistasis in hPGCs; PRDM1 KO/OE in colon organoids with RNA-seq

    PMID:29713018 PMID:29760071 PMID:30051906

    Open questions at the time
    • Mechanism handing off granzyme B maintenance to Hobit not detailed
    • Direct germline target genes of the PAX5-OCT4-PRDM1 network incompletely enumerated
  18. 2019 High

    Elaborated how BLIMP1 stabilizes Treg identity and instructs Th2/IL-10 programs, including epigenetic protection of the Foxp3 locus and locus-specific histone-demethylase recruitment.

    Evidence Treg-specific KO with bisulfite sequencing and Dnmt3a ChIP in EAE; Il10 activation assays; Bcl6/GATA3 staining in allergen models; ChIP of Blimp-1/LSD1 at Pdcd1; ChIP/Kdm4a recruitment in chick neural progenitors

    PMID:28935958 PMID:30759395 PMID:31806661 PMID:31811020 PMID:32399548

    Open questions at the time
    • Why the Blimp-1/LSD1 axis operates in acute but not chronic infection unresolved
    • Switch between repressive and activating recruitment at different loci unexplained
  19. 2020 Medium

    Linked the BLIMP1-driven IL-10 Treg program to systemic metabolic homeostasis and adipose browning.

    Evidence Treg-specific knockout on high-fat diet with metabolic phenotyping and WAT beiging assessment

    PMID:33351782

    Open questions at the time
    • Direct adipose-resident Treg targets not identified
    • Single-lab metabolic phenotype
  20. 2022 High

    Defined PRDM1 as a barrier to durable T-cell memory and antitumor function, and uncovered a transcriptional-activation axis promoting tumor immune evasion.

    Evidence CRISPR KO of PRDM1 (and dual KO with NR4A3) in CAR-T cells with ATAC-seq, scRNA-seq, and in vivo tumor models; PRDM1-USP22-SPI1-PD-L1 pathway dissection in HCC with deubiquitination assays

    PMID:34861037 PMID:36350986 PMID:36509766

    Open questions at the time
    • Compensatory NR4A3 program complicates single-target ablation strategies
    • How PRDM1 switches to USP22 activation versus repression elsewhere unresolved
  21. 2024 High

    Quantified the BLIMP1:BACH2 balance as a tunable determinant of memory B cell fate, integrating stimulation history encoded epigenetically by IRF4.

    Evidence single-cell ATAC-seq and transcriptomics of antigen-responding B cells with genetic fate-switching and GC lineage tracing

    PMID:38969872

    Open questions at the time
    • Molecular sensors setting the balance threshold not fully defined
    • How IRF4-opened loci feed back onto Prdm1 incompletely mapped

Open questions

Synthesis pass · forward-looking unresolved questions
  • The determinants that switch BLIMP1 between transcriptional repression and activation at individual loci, and the cofactor logic selecting among its Groucho/HDAC/G9a/Kdm4a/LSD1 effector arms, remain unresolved.
  • No structural model of BLIMP1 bound to DNA with a corepressor
  • No predictive rule distinguishing activated from repressed targets from sequence/chromatin context
  • How upstream signals select among alternative Prdm1 promoters and effector complexes is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 10 GO:0003677 DNA binding 6 GO:0098772 molecular function regulator activity 4
Localization
GO:0000228 nuclear chromosome 3 GO:0005634 nucleus 2
Pathway
R-HSA-168256 Immune System 7 R-HSA-74160 Gene expression (Transcription) 7 R-HSA-4839726 Chromatin organization 6 R-HSA-1643685 Disease 5 R-HSA-1266738 Developmental Biology 4
Partners
FBXO11G9AHDACKDM4ALSD1OCT4PAX5TLE1

Evidence

Reading pass · 43 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 PRDI-BF1 (PRDM1) requires only its first two C2H2 zinc fingers (ZF1 and ZF2) together for sequence-specific binding to the PRDI element of the beta-interferon gene promoter; ZF1 or ZF2 alone, ZF2–5, or ZF1+2 in reverse order are insufficient. Zinc finger domain-swap mutagenesis into a heterologous zinc finger protein, DNA-binding assay Molecular and cellular biology High 1569931
1999 PRDI-BF1/Blimp-1 represses transcription through an active mechanism by recruiting Groucho-family corepressors (hGrg, TLE1, TLE2) via a defined minimal repression domain; dominant-negative Groucho fragments relieve IFN-beta repression, placing Groucho complexes as essential effectors of PRDI-BF1-mediated silencing. Gal4-fusion repression assays, GST pulldown/protein interaction mapping, dominant-negative overexpression, IFN-beta promoter activity assays Genes & development High 9887105
2000 Blimp-1 represses c-myc transcription by recruiting histone deacetylase (HDAC) to the c-myc promoter; two independent HDAC-associating regions exist in Blimp-1, the HDAC inhibitor TSA blocks Blimp-1-dependent repression, and Blimp-1 expression causes H3 deacetylation at the c-myc Blimp-1 binding site in a site-dependent manner. Gal4-fusion cotransfection repression assays, co-immunoprecipitation of HDAC with Blimp-1 from nuclear extracts, TSA inhibitor treatment, chromatin immunoprecipitation (ChIP) Molecular and cellular biology High 10713181
2004 PRDI-BF1 (human PRDM1) assembles silent chromatin over the IFN-beta promoter by recruiting the histone H3 lysine methyltransferase G9a; G9a is only recruited when in complex with PRDI-BF1, and G9a catalytic activity is required for H3 methylation accumulation and PRDI-BF1-mediated transcriptional silencing in vivo. Co-immunoprecipitation, chromatin immunoprecipitation (ChIP), G9a catalytic-mutant functional assays in U2OS cells Nature immunology High 14985713
2006 Blimp-1 is required for T cell homeostasis and self-tolerance; mice reconstituted with fetal liver cells expressing a DNA-binding domain-deleted Blimp-1 develop lethal multiorgan inflammatory disease due to accumulation of effector and memory T cells, demonstrating that the DNA-binding activity of Blimp-1 is essential for its function in T cells. Conditional loss-of-function mouse model (DNA-binding domain deletion), fetal liver reconstitution, immunophenotyping Nature immunology High 16565720
2006 Blimp-1 is required for T cell homeostasis; Blimp-1-deficient mice show increased peripheral effector T cells, severe colitis, and Blimp-1-deficient CD4+ T cells overproduce IL-2 and IFN-γ but produce less IL-10 after TCR stimulation, establishing Blimp-1 as a repressor of T cell activation and cytokine production. Conditional Blimp-1 knockout mice, T cell transfer colitis model, intracellular cytokine assay, proliferation assay Nature immunology High 16565721
2006 Blimp-1 is required for immunoglobulin secretion by B-1 cells; B-1 cells lacking Blimp-1 fail to repress Pax5 mRNA, fail to induce XBP-1, and cannot secrete normal levels of IgM, demonstrating that B-1 and B-2 cells share a common Blimp-1-dependent pathway for Ig secretion. B-cell-lineage-specific Blimp-1 knockout mice, RT-PCR for Pax5/XBP-1, ELISA for IgM secretion, influenza infection model The Journal of experimental medicine High 16954370
2007 BLIMP1 represses p53 transcription by binding directly to the p53 promoter, forming an autoregulatory feedback loop: p53 positively regulates BLIMP1, and BLIMP1 in turn represses p53 transcription; BLIMP1 knockdown raises p53 mRNA and protein, induces p53-target genes, and causes apoptosis that is rescued by p53 depletion. siRNA knockdown, promoter-binding ChIP, p53-null cell rescue experiments, RT-PCR, western blot Proceedings of the National Academy of Sciences of the United States of America High 17264218
2007 BLIMP1 (Blimp-1) negatively regulates IL-2 production in activated T cells via a cytokine-dependent feedback loop: IL-2 induces Blimp-1 expression, and ectopic Blimp-1 in turn represses IL-2 production while promoting granzyme B and CD25 expression. Microarray analysis, ectopic overexpression of Blimp-1, intracellular cytokine assay in CD4+ and CD8+ T cells Journal of immunology Medium 17182561
2007 Human BSAP (PAX5) binds to the PRDM1 promoter and represses BLIMP1 expression, revealing an autoregulatory negative-feedback loop in which BLIMP1 represses PAX5 and PAX5 represses BLIMP1. EMSA (electrophoretic mobility shift assay), ChIP confirming in vivo PAX5 binding to PRDM1 promoter, ectopic BSAP expression with promoter mutant analysis Blood High 17682124
2009 Bcl6 and Blimp-1 act as reciprocal antagonistic regulators of T follicular helper (TFH) cell differentiation: Bcl6 expression in CD4+ T cells is necessary and sufficient for TFH differentiation in vivo, whereas Blimp-1 inhibits TFH differentiation and thereby prevents B cell germinal center and antibody responses. Conditional knockout mice (Bcl6 and Blimp-1), in vivo immunization models, flow cytometry, adoptive transfer Science High 19608860
2009 Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12 in myeloid cells; Blimp-1 binds the NLRP12 promoter in a TLR-inducible manner, reduces NLRP12 promoter activity and histone 3 acetylation, and physiological evidence from Blimp-1-deficient murine myeloid cells confirms this regulation. ChIP, promoter activity assays, TLR stimulation, Blimp-1-knockout myeloid cell analysis Journal of immunology High 19234190
2009 The mouse Prdm1 gene has three alternative promoter regions, and NF-κB binding sites in the previously described first exon are required for Prdm1 induction by LPS; deletion of exon 1 abolishes lipopolysaccharide-induced Prdm1 expression in B cells and blocks antibody-secreting cell formation. Targeted deletion mouse models of individual Prdm1 promoter/exon regions, LPS stimulation of B cells, ELISA for antibody secretion Molecular and cellular biology High 19737919
2010 PRDM1/Blimp-1 directly binds conserved regulatory regions of IFNG and TNF loci in NK cells, coordinately repressing IFN-γ, TNF-α, and TNF-β production; PRDM1 ablation enhances cytokine production without affecting cytotoxicity, and overexpression blocks cytokine production. ChIP confirming direct PRDM1 binding at IFNG and TNF loci, shRNA knockdown, overexpression, intracellular cytokine assay in human NK cells Journal of immunology High 20944005
2010 Blimp1 (Prdm1) conditional deletion in the mouse retina causes Otx2+ photoreceptor precursors to ectopically express bipolar cell markers (Chx10/Vsx2 and Vsx1) and adopt bipolar instead of photoreceptor fate, demonstrating that Blimp1 stabilizes immature photoreceptors by preventing bipolar cell induction. Conditional knockout mouse (retina-specific Prdm1 deletion), developmental immunostaining, fate marker analysis Development High 20110327
2010 BLIMP1 DNA-binding is methylation-sensitive; multiple binding motif variants are required to capture full BLIMP1 occupancy in vivo, and BLIMP1 occupancy at promoters with overlapping BLIMP1/IRF motifs constitutes a dynamic target set preferentially activated by BLIMP1 knockdown, confirming competitive antagonism between BLIMP1 and IRFs. ChIP-seq (genome-wide BLIMP1 occupancy mapping), motif discovery, CpG methylation analysis, BLIMP1 knockdown with transcriptome analysis Nucleic acids research High 20421211
2010 Prdm1 reconstitution in PRDM1-null NK cell lines leads to G2/M cell cycle arrest and increased apoptosis, and MYC and 4-1BBL are identified as direct targets of PRDM1 in NK cells, supporting its tumor suppressor function in NK cell malignancies. Retroviral reconstitution of PRDM1 in NK cell lines, cell cycle analysis, apoptosis assays, target gene identification Proceedings of the National Academy of Sciences of the United States of America Medium 22143801
2012 Blimp1/Prdm1 in trophoblast cells is required for terminal differentiation of invasive spiral artery-associated trophoblast giant cells (SpA-TGCs) and expansion of the spongiotrophoblast layer; lineage tracing with a Prdm1.Cre-LacZ allele demonstrates that Blimp1+ diploid progenitors give rise to SpA-TGCs, canal TGCs, and glycogen trophoblasts. Conditional trophoblast-specific Prdm1 knockout, Prdm1.Cre-LacZ lineage tracing, developmental histology Genes & development High 22987638
2013 Blimp1-deficient dendritic cells (DCs) exhibit elevated MHC II expression and enhanced proinflammatory cytokine secretion; BLIMP1 regulates this phenotype indirectly through the microRNA let-7c, which is upregulated when Blimp1 is absent; let-7c in turn inhibits SOCS1 expression, amplifying pro-inflammatory signaling. DC-specific Blimp1 knockout mouse, miRNA expression profiling, let-7c overexpression and inhibition, flow cytometry, cytokine ELISA The Journal of clinical investigation High 23298838
2014 In C. elegans, BLMP-1 (Blimp-1 ortholog) prevents precocious dorsalward turning of distal tip cells by inhibiting unc-5 transcription; correct timing of BLMP-1 downregulation is controlled by DAF-12 (steroid hormone receptor) and LIN-29 (transcription factor) repressing blmp-1 transcription, and DRE-1/FBXO11 (SCF ubiquitin ligase F-box protein) binding to BLMP-1 and promoting its degradation. Human FBXO11 also binds PRDI-BF1 in human cell cultures. C. elegans genetics (constitutive expression, morpholino knockdown, double mutants), co-immunoprecipitation of DRE-1/FBXO11 with BLMP-1/PRDI-BF1 in human cells PLoS genetics Medium 24968003
2015 Blimp-1 binds an IFN-stimulated response element within the HIV-1 provirus in CD4+ memory T cells, repressing both basal and Tat-mediated HIV-1 transcription; Blimp-1 reduction in primary CD4+ memory T cells increases RNA polymerase II processivity, histone acetylation, and HIV-1 transcription. ChIP demonstrating Blimp-1 occupancy at HIV-1 ISRE, siRNA knockdown in primary T cells, RNA pol II ChIP, histone acetylation ChIP Journal of immunology High 25710909
2015 VEGF/VEGFR2 signaling through Erk1/2 and Stat3 upregulates PRD1-BF1/Blimp1 in tumor vascular endothelial cells; nuclear Blimp1 then directly represses genes involved in type I interferon-mediated antiviral signaling, sensitizing tumor vasculature to oncolytic vaccinia virus infection. Signaling pathway inhibitors (Erk1/2, Stat3), immunofluorescence of nuclear Blimp1 localization, in vivo VEGF signaling suppression with functional antiviral gene expression readout Cancer cell Medium 26212250
2015 Blimp1/Prdm1 in the neonatal intestinal epithelium directly binds and represses promoters of MHC class I pathway components (including ERAP1, TAPASIN, LMP7, MECL1), as revealed by genome-wide ChIP-seq; Blimp1 functions in opposition to the transcriptional activator Irf1 at these loci to prevent premature MHC class I expression and maintain neonatal intestinal tolerance. ChIP-seq (eGFP-Blimp1 knock-in), comparison with Irf1 ChIP-seq, genetic knockout analysis of neonatal intestinal gene expression PLoS genetics High 26158850
2016 Bach2, a transcription factor that represses Blimp-1 expression in B cells, associates in a complex with HDAC3, NCoR1, NCoR2, Tbl1x, and Rif1 at the Prdm1 locus; HDAC3 and Rif1 bind the Prdm1 intron 5 MARE region, and knockdown of HDAC3 or NCoR1 increases Prdm1 mRNA in B cells. Co-immunoprecipitation/mass spectrometry of Bach2 complex, ChIP of HDAC3 and Rif1 at Prdm1 locus, RNAi knockdown of HDAC3/NCoR1, histone acetylation/methylation analysis by ChIP The Journal of biological chemistry High 26786103
2017 PRDM1 is required for response to bortezomib in mantle cell lymphoma; bortezomib rapidly induces PRDM1 transcription, and PRDM1 knockdown blocks NOXA activation and apoptosis; PRDM1 directly represses MKI67 and PCNA via specific binding sites in their promoters as shown by ChIP and promoter mutation analysis. siRNA knockdown, ectopic PRDM1 overexpression, ChIP, promoter deletion/mutation reporter assays, apoptosis assays Molecular cancer research High 20530581
2017 BLIMP1 drives PDAC metastasis as a transcriptional regulator; hypoxia induces BLIMP1, which regulates a subset of hypoxia-associated gene expression programs, and BLIMP1 expression marks a highly metastatic cancer cell subpopulation with stem cell character. Genetically engineered mouse model of PDAC, global gene expression profiling, BLIMP1 gain/loss-of-function in cancer cells, hypoxia treatment Cancer discovery Medium 28790031
2018 PAX5 (BSAP) and OCT4 switch binding partners during germ cell specification: in pluripotent cells OCT4 partners with SOX2, whereas in hPGC development OCT4 partners with PAX5 and PRDM1; epistasis analysis places PAX5 upstream of OCT4 and PRDM1, forming a core PAX5-OCT4-PRDM1 transcriptional network that activates germline and represses somatic programs. OCT4 ChIP-seq in hPGCs vs. hESCs, gain/loss-of-function (CRISPR KO, overexpression) of PAX5, epistasis analysis, engraftment assay Nature cell biology High 29713018
2018 PRDM1β (an isoform of PRDM1) is a p53-response gene; both α and β isoforms of PRDM1 repress MYC-response genes and stem cell-related genes; forced PRDM1 expression in human colon cancer organoids prevents their formation and growth. PRDM1 knockout and overexpression in RKO cells and human colon organoids, RNA-seq (transcript landscape), organoid growth assays Proceedings of the National Academy of Sciences of the United States of America Medium 29760071
2018 Blimp-1 initiates granzyme B expression in murine effector CD8 T cells and tissue-resident memory T cells (Trm) during the effector stage; Blimp-1 protein is only transiently expressed during effector stage while Hobit protein is stably maintained during quiescence and specifically maintains granzyme B in Trm during the memory phase. Murine Blimp-1 conditional KO, protein/mRNA expression time-course analysis, granzyme B immunostaining in effector and memory T cell subsets European journal of immunology Medium 30051906
2019 Blimp-1 prevents demethylation-driven loss of Foxp3 expression in CNS Treg cells during EAE by negatively regulating IL-6/STAT3-dependent Dnmt3a expression and function, thereby restraining methylation of Treg-specific CNS2 in the Foxp3 locus; Blimp1 ablation in Tregs leads to heavy CNS2 methylation, loss of Foxp3, and severe autoimmune disease. Treg-specific Blimp1 conditional KO, bisulfite sequencing of Foxp3 CNS2, DNMT3a ChIP, EAE model Cell reports High 30759395
2019 Blimp-1 directly activates the Il10 gene in both effector and regulatory T cells, with Treg-intrinsic Blimp-1 being essential for IL-10 expression and full effector Treg functionality but dispensable for preventing spontaneous intestinal inflammation. Foxp3-Cre Blimp-1 conditional KO mice, cytokine ELISA, intracellular cytokine staining, colitis scoring Scientific reports Medium 28935958
2019 Blimp1 directly activates the expression of neural, neural crest, and sensory progenitor specifier genes in chick epiblast by binding to their promoter regions and recruiting the histone demethylase Kdm4a to remove repressive histone marks; once neural lineage determinants are expressed, they in turn repress PRDM1. ChIP demonstrating PRDM1 binding at target promoters, Kdm4a co-recruitment assay, gain- and loss-of-function in chick embryo, repressive histone mark analysis Development High 31806661
2019 During acute LCMV infection, Blimp-1 recruits LSD1 to the Pdcd1 (PD-1) gene locus, downregulates PD-1 expression by facilitating removal of activating histone marks, and is required for remethylation of the Pdcd1 locus; in chronic infection this Blimp-1/LSD1 axis is not operative. LSD1-deficient CD8 T cells, ChIP of Blimp-1 and LSD1 at Pdcd1 locus, DNA methylation analysis, LCMV acute vs. chronic infection models, murine melanoma model Journal of immunology High 31811020
2020 Treg-specific loss of Blimp-1 reduces ST2+KLRG1+ IL-10-secreting Tregs in white adipose tissue, protecting mice from glucose intolerance, insulin resistance, and diet-induced obesity through increased white adipose tissue browning, establishing a Blimp-1-regulated IL-10 Treg axis in metabolic homeostasis. Treg-specific Blimp-1 knockout mice on high-fat diet, metabolic phenotyping, flow cytometry, WAT beiging assessment JCI insight Medium 33351782
2020 Blimp-1 promotes Th2 cell development in the lung through repression of Bcl6, leading to increased GATA3 expression; this pathway requires IL-10/STAT3-dependent induction of Blimp-1 and is specific to inhaled allergens but dispensable for TFH function. T cell-specific Blimp-1 conditional KO, house dust mite/OVA allergen models, intracellular GATA3/Bcl6 staining, IL-10 neutralization/STAT3 inhibition The Journal of experimental medicine Medium 32399548
2022 PRDM1 CRISPR/Cas9 knockout in CAR-T cells promotes an early memory phenotype and polyfunctional cytokine secretion by increasing chromatin accessibility at memory-associated gene loci; PRDM1-ablated T cells show enhanced persistence and improved antitumor efficacy in multiple tumor models. CRISPR/Cas9 knockout of PRDM1 in CAR-T cells, ATAC-seq (chromatin accessibility), in vivo tumor models, cytokine profiling Blood High 34861037
2022 PRDM1 enhances USP22 transcription, which in turn deubiquitinates and stabilizes the transcription factor SPI1, which then activates PD-L1 transcription in hepatocellular carcinoma cells, thereby dampening anti-tumor CD8+ T cell immunity; this PRDM1-USP22-SPI1-PD-L1 axis represents a transcriptional activation (not repression) function for PRDM1. PRDM1 overexpression/knockdown in HCC cells and mouse models, USP22 promoter reporter, SPI1 ubiquitination/deubiquitination assay, PD-L1 expression and CD8+ T cell co-culture assays Nature communications Medium 36509766
2022 Dual CRISPR knockout of PRDM1 and NR4A3 in CAR-T cells skews phenotype from TIM-3+CD8+ toward TCF1+CD8+ and counters exhaustion of tumor-infiltrating CAR-T cells; PRDM1 deficiency alone activates a compensatory NFAT-driven NR4A3-upregulation exhaustion program, not achieved by either single KO. Single and dual CRISPR KO of PRDM1 and NR4A3 in CAR-T cells, scRNA-seq, in vivo solid tumor models Science translational medicine Medium 36350986
2024 The relative balance between BLIMP1 and BACH2 progressively shifts in favor of BLIMP1 during primary B cell responses; this balance dictates memory B cell fate upon recall—higher BLIMP1:BACH2 favors plasma cell development and lower BLIMP1:BACH2 favors secondary germinal center formation; skewing this balance experimentally switches fate preferences; IRF4 epigenetically encodes stimulation history by opening PC-specific chromatin loci in a stimulation-strength-dependent manner. Single-cell epigenomics (scATAC-seq) and transcriptomics of antigen-responding B cells, genetic manipulation of BLIMP1/BACH2 balance in fate-predisposed MBC subsets, GC B cell lineage tracing, ChIP/ATAC at ISRE loci Nature immunology High 38969872
2007 PRDM1/BLIMP-1 represses genes of the MHC class I antigen-processing and peptide-loading pathway (ERAP1, TAPASIN, MECL1, LMP7) by antagonizing IFN-γ-driven transcription at conserved IRF-element-containing promoters, resulting in failure to upregulate surface MHC class I in response to IFN-γ. Promoter reporter assays, PRDM1 expression in human cell lines, sea urchin prdm1 ortholog evolutionary comparison, surface MHC class I flow cytometry Journal of immunology Medium 18025207
2006 BLIMP-1 is a downstream target of the unfolded protein response (UPR): BLIMP-1 mRNA is rapidly induced at the transcriptional level during UPR in human myeloid and B-cell lines in a PERK-dependent, new-protein-synthesis-independent, and NF-κB-dependent manner. UPR induction with chemical agents, transcriptional run-on/mRNA induction assays, PERK-pathway inhibition, NF-κB inhibition, conserved in murine B cells and macrophages European journal of immunology Medium 16708403
2015 Blimp-1/PRDM1 directly binds and transcriptionally activates (rather than represses) the CS1/SLAMF7 gene promoter in NK and B cells, as demonstrated by EMSA and ChIP; mutation of the PRDM1 binding site at -750 to -746 reduces CS1 promoter activity, revealing a context-dependent trans-activating function for PRDM1. EMSA, ChIP, promoter deletion and mutation reporter assays in NK and B cell lines Immunobiology Medium 26310579
2009 PRDM1/BLIMP-1 represses primary miR-21 transcription during IL-21-driven plasma cell differentiation, counteracting STAT3-mediated miR-21 induction; BLIMP-1 and STAT3 form an incoherent feed-forward loop downstream of IL-21 that coordinates microRNA with mRNA expression. Primary miR-21 transcription analysis, promoter binding assays, phospho-STAT3 ChIP, BLIMP-1 overexpression in B cell differentiation cultures Journal of immunology Medium 22634616

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (New York, N.Y.) 1339 19608860
2010 Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nature immunology 428 20084069
2008 Regulation and functions of Blimp-1 in T and B lymphocytes. Annual review of immunology 308 18370921
2006 Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. Nature immunology 307 16565721
2004 PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. Nature immunology 293 14985713
2006 Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. The Journal of experimental medicine 289 16492805
2000 Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. Molecular and cellular biology 273 10713181
2006 Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nature immunology 264 16565720
1999 PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Genes & development 227 9887105
2011 Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population. Annals of the rheumatic diseases 187 21622776
2007 Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production. Journal of immunology (Baltimore, Md. : 1950) 154 17182561
2008 MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: a potential pathogenetic lesion in Hodgkin lymphomas. The American journal of pathology 130 18583325
2007 BLIMP1 guides the fate of effector B and T cells. Nature reviews. Immunology 125 17965637
2010 Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development (Cambridge, England) 124 20110327
2022 Genetic ablation of PRDM1 in antitumor T cells enhances therapeutic efficacy of adoptive immunotherapy. Blood 116 34861037
2022 BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustion. Science translational medicine 116 36350986
2007 Terminal differentiation of lymphocytes depends on Blimp-1. Current opinion in immunology 113 17291741
2019 Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation. Cell reports 112 30759395
2011 PRDM1 is a tumor suppressor gene in natural killer cell malignancies. Proceedings of the National Academy of Sciences of the United States of America 108 22143801
2013 PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma. Blood 103 24004669
2009 An expanding job description for Blimp-1/PRDM1. Current opinion in genetics & development 100 19592232
2022 PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells. Nature communications 99 36509766
2017 New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function. Journal of biomedical science 97 28732506
2015 VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection. Cancer cell 97 26212250
2015 Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans. European journal of immunology 96 26179882
1992 Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding. Molecular and cellular biology 94 1569931
2017 Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells. The Journal of experimental medicine 88 28698287
2010 PRDM1/Blimp-1 controls effector cytokine production in human NK cells. Journal of immunology (Baltimore, Md. : 1950) 85 20944005
2021 Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis. JCI insight 84 33351782
2021 AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1-Bcl-6 axis-mediated B-cell differentiation. Signal transduction and targeted therapy 82 34521812
2017 Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. Annals of the rheumatic diseases 82 28314753
2008 Blimp1: a conserved transcriptional repressor critical for differentiation of many tissues. Experimental cell research 81 19073176
2005 Essential roles of a zebrafish prdm1/blimp1 homolog in embryo patterning and organogenesis. Development (Cambridge, England) 81 15623803
2005 PRDM1/Blimp-1 is expressed in human B-lymphocytes committed to the plasma cell lineage. The Journal of pathology 81 15772984
2023 BCL6 promotes a stem-like CD8+ T cell program in cancer via antagonizing BLIMP1. Science immunology 80 37862431
2018 Blimp-1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 T cells. European journal of immunology 77 30051906
2006 B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion. The Journal of experimental medicine 77 16954370
2008 Activation-dependent induction of Blimp-1. Current opinion in immunology 75 18554885
2006 PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma. Haematologica 74 16585013
2013 Regulation of dendritic cell activation by microRNA let-7c and BLIMP1. The Journal of clinical investigation 71 23298838
2010 Follicular dendritic cell-induced microRNA-mediated upregulation of PRDM1 and downregulation of BCL-6 in non-Hodgkin's B-cell lymphomas. Leukemia 71 20966935
2014 PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas. Leukemia & lymphoma 66 25115512
2007 BLIMP1 regulates cell growth through repression of p53 transcription. Proceedings of the National Academy of Sciences of the United States of America 66 17264218
2016 Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3. The Journal of biological chemistry 65 26786103
2012 Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. Genes & development 63 22987638
2020 IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivity. The Journal of allergy and clinical immunology 62 32905799
2008 Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression. Blood 61 18552212
2006 Immunization-induced perturbation of human blood plasma cell pool: progressive maturation, IL-6 responsiveness, and high PRDI-BF1/BLIMP1 expression are critical distinctions between antigen-specific and nonspecific plasma cells. Journal of immunology (Baltimore, Md. : 1950) 60 16547239
2017 BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer. Cancer discovery 59 28790031
2015 EBV-miR-BHRF1-2 targets PRDM1/Blimp1: potential role in EBV lymphomagenesis. Leukemia 58 26530011
2010 An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression. Nucleic acids research 51 20421211
2009 Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation. Molecular and cellular biology 49 19737919
2018 PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids. Proceedings of the National Academy of Sciences of the United States of America 48 29760071
2020 Bcl6 and Blimp1 reciprocally regulate ST2+ Treg-cell development in the context of allergic airway inflammation. The Journal of allergy and clinical immunology 47 32179158
2017 Differential regulation of Effector and Regulatory T cell function by Blimp1. Scientific reports 44 28935958
2012 BLIMP-1 and STAT3 counterregulate microRNA-21 during plasma cell differentiation. Journal of immunology (Baltimore, Md. : 1950) 44 22634616
2020 Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lung. The Journal of experimental medicine 43 32399548
2018 Characterization of Blimp-1 function in effector regulatory T cells. Journal of autoimmunity 43 29724515
2011 Blimp1 expression predicts embryonic stem cell development in vitro. Current biology : CB 42 22000107
2007 PRDM1/BLIMP-1 modulates IFN-gamma-dependent control of the MHC class I antigen-processing and peptide-loading pathway. Journal of immunology (Baltimore, Md. : 1950) 37 18025207
2006 BLIMP-1 is a target of cellular stress and downstream of the unfolded protein response. European journal of immunology 37 16708403
2022 Conserved and Unique Functions of Blimp1 in Immune Cells. Frontiers in immunology 36 35154079
1996 The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10. Genomics 36 8921366
2019 Blimp-1 Contributes to the Development and Function of Regulatory B Cells. Frontiers in immunology 35 31474988
2019 PD-1 Expression during Acute Infection Is Repressed through an LSD1-Blimp-1 Axis. Journal of immunology (Baltimore, Md. : 1950) 34 31811020
2018 A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells. Nature cell biology 34 29713018
2017 Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice. European journal of immunology 34 28586108
2017 Downregulation of PRDM1 promotes cellular invasion and lung cancer metastasis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 32 28378641
2015 Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases. Immunologic research 32 26376898
2024 Epigenetic recording of stimulation history reveals BLIMP1-BACH2 balance in determining memory B cell fate upon recall challenge. Nature immunology 30 38969872
2011 CD99 triggers upregulation of miR-9-modulated PRDM1/BLIMP1 in Hodgkin/Reed-Sternberg cells and induces redifferentiation. International journal of cancer 30 22020966
2009 Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1. Journal of immunology (Baltimore, Md. : 1950) 30 19234190
2007 Human BSAP and BLIMP1 conform an autoregulatory feedback loop. Blood 30 17682124
2018 PI3K-Mediated Blimp-1 Activation Controls B Cell Selection and Homeostasis. Cell reports 29 29996100
2015 Blimp-1, an intrinsic factor that represses HIV-1 proviral transcription in memory CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950) 29 25710909
2015 Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation. PLoS genetics 29 26158850
2016 Hypermethylation of PRDM1/Blimp-1 promoter in extranodal NK/T-cell lymphoma, nasal type: an evidence of predominant role in its downregulation. Hematological oncology 28 27704586
2014 Variable induction of PRDM1 and differentiation in chronic lymphocytic leukemia is associated with anergy. Blood 28 24637363
2014 BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans. PLoS genetics 27 24968003
2022 Hobit and Blimp-1 regulate TRM abundance after LCMV infection by suppressing tissue exit pathways of TRM precursors. European journal of immunology 26 35389518
2015 Blimp-1/PRDM1 regulates the transcription of human CS1 (SLAMF7) gene in NK and B cells. Immunobiology 26 26310579
2010 PRDM1 is required for mantle cell lymphoma response to bortezomib. Molecular cancer research : MCR 26 20530581
2022 Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis. Cellular immunology 25 36081178
2021 Overexpression of transcription factor BLIMP1/prdm1 leads to growth inhibition and enhanced secretory capacity in Chinese hamster ovary cells. Metabolic engineering 25 34265400
2016 PRDM1, a Tumor-Suppressor Gene, is Induced by Genkwadaphnin in Human Colon Cancer SW620 Cells. Journal of cellular biochemistry 25 26096175
2019 JAK3/STAT3 oncogenic pathway and PRDM1 expression stratify clinicopathologic features of extranodal NK/T‑cell lymphoma, nasal type. Oncology reports 24 31002364
2019 PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants. Development (Cambridge, England) 24 31806661
2018 Pan-HDAC Inhibitors Restore PRDM1 Response to IL21 in CREBBP-Mutated Follicular Lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research 24 30348636
2020 Hypomethylation of PRDM1 is associated with recurrent pregnancy loss. Journal of cellular and molecular medicine 22 32349189
2017 Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion. Scientific reports 22 28442738
2017 Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. Journal of immunology (Baltimore, Md. : 1950) 22 28701508
2017 Transcriptional repressor Blimp1 regulates follicular regulatory T-cell homeostasis and function. Immunology 22 28833081
2024 Inhibition of USP7 enhances CD8+ T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation. Acta pharmacologica Sinica 21 38589688
2011 The role of BLIMP1 and its putative downstream target TFAP2C in germ cell development and germ cell tumours. International journal of andrology 21 21564135
2021 BMP4 activates the Wnt-Lin28A-Blimp1-Wnt pathway to promote primordial germ cell formation via altering H3K4me2. Journal of cell science 20 33443086
2021 Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4+ T cells. The Journal of experimental medicine 20 34792530
2020 Prdm1 overexpression causes a photoreceptor fate-shift in nascent, but not mature, bipolar cells. Developmental biology 20 32562755
2017 Transglutaminase 2 regulates osteoclast differentiation via a Blimp1-dependent pathway. Scientific reports 20 28878266
2014 Hypermethylation of the tumor suppressor gene PRDM1/Blimp-1 supports a pathogenetic role in EBV-positive Burkitt lymphoma. Blood cancer journal 20 25382611
2010 Blimp-1 is a tumor suppressor gene in lymphoid malignancies. International journal of hematology 20 20047096

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