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Showing PPRC1 — PRC is a alias.

PPRC1

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 · UniProt Q5VV67

Length
1664 aa
Mass
177.5 kDa
Annotated
2026-06-10
75 papers in source corpus 11 papers cited in narrative 11 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PPRC1 (PRC) is a growth-regulated transcriptional coactivator required for mitochondrial respiratory chain gene expression and normal mitochondrial biogenesis (PMID:19036724). Its depletion in human cells reduces expression of complex I–IV subunits, lowers complex I and IV enzyme activities and mitochondrial ATP production, produces structurally abnormal mitochondria lacking organized cristae, and impairs glucose-supported growth and G1/S progression, establishing PPRC1 as essential for both respiratory function and cell cycle progression (PMID:19036724). PPRC1 protein stability is post-translationally controlled by GSK-3-mediated phosphorylation at two C-terminal serines; mitochondrial uncoupling activates Akt, which inactivates GSK-3β and extends PPRC1 half-life, and PPRC1 acts in concert with c-MYC through this Akt-GSK-3 axis to reprogram gene expression under mitochondrial stress (PMID:27789709). The PPRC1 program is induced downstream of intracellular ROS and during apoptosis and premature senescence, driving target genes such as IL1α and the SPRR2 family, and PPRC1 can also be induced through a cAMP/CREB-dependent route that substitutes for absent PGC-1α activity to restore mitochondrial homeostasis (PMID:23364789, PMID:33087445). Beyond its core biogenesis role, PPRC1 suppresses NF-κB-dependent endothelial inflammation (PMID:23954632) and cooperates with STAT6 to promote microglial M2 polarization (PMID:24838382). In vivo, Pprc1 haploinsufficiency in mice perturbs PGC-family and respiratory-chain gene expression and confers resistance to diet-induced obesity with elevated energy expenditure (PMID:25994039). A point mutation in PPRC1 (p.Thr958Ile) was identified in a family with premature ovarian failure (PMID:33818872).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2008 High

    Established that PPRC1 is functionally required for mitochondrial respiratory function rather than merely correlated with it, resolving whether the PGC-1 family member PRC has a non-redundant biogenesis role.

    Evidence Stable lentiviral shRNA knockdown in U2OS cells with respiratory enzyme assays, EM mitochondrial morphology, ATP and cell cycle readouts

    PMID:19036724

    Open questions at the time
    • Does not identify direct transcription-factor partners through which PPRC1 activates respiratory genes
    • Mechanism linking respiratory defect to G1/S arrest not defined
  2. 2013 Medium

    Defined the upstream signals that activate the PPRC1 program, placing it downstream of intracellular ROS and linking it to apoptosis, senescence, and glycolytic metabolic shifts.

    Evidence Pharmacological induction/inhibition (menadione, SN-38, meclizine, N-acetylcysteine) with immunoblotting, SA-β-gal and lactate assays

    PMID:23364789

    Open questions at the time
    • No direct mutagenesis or structural mapping of the stress-responsive elements
    • Coordinate c-MYC/PRC induction observed but causal hierarchy not yet established in this study
  3. 2013 Medium

    Showed PPRC1 acts as an anti-inflammatory regulator in endothelium, connecting its mitochondrial/metabolic role to suppression of NF-κB signaling.

    Evidence PPRC1 overexpression in HUVECs with monocyte adhesion, VCAM-1/E-selectin immunoblotting, NF-κB reporter and metabolic assays

    PMID:23954632

    Open questions at the time
    • Gain-of-function only; no loss-of-function confirmation
    • Direct molecular link between PPRC1 and NF-κB not defined
  4. 2014 Medium

    Extended PPRC1 function into immune cell programming by showing it cooperates with STAT6 to drive microglial M2 polarization.

    Evidence PPRC1 overexpression and siRNA silencing in microglia, qRT-PCR of M2 markers, STAT6 co-operation/co-IP assay

    PMID:24838382

    Open questions at the time
    • Direct PPRC1-STAT6 binding interface not mapped
    • Reciprocal validation of the interaction limited
  5. 2015 Medium

    Provided in vivo genetic evidence that Pprc1 controls mitochondrial gene expression and whole-body energy metabolism.

    Evidence Heterozygous Pprc1 knockout mice on high-fat diet, metabolic phenotyping and PGC-family/respiratory gene expression analysis

    PMID:25994039

    Open questions at the time
    • Whole-body knockout lethal, so only heterozygotes assessed
    • Tissue-specific mechanisms (muscle haploinsufficiency vs adipose compensation) not fully resolved
  6. 2016 High

    Defined the post-translational control of PPRC1, showing GSK-3 phosphorylation destabilizes the protein and Akt-mediated GSK-3 inactivation stabilizes it, with c-MYC required for the stress program.

    Evidence GSK-3 phosphosite mutagenesis, c-MYC siRNA and inhibitor, Akt/GSK-3 inhibitors, CCCP, protein half-life and reporter assays

    PMID:27789709

    Open questions at the time
    • Identity of the kinase priming GSK-3 phosphorylation not established
    • How c-MYC and PPRC1 jointly engage target promoters not resolved
  7. 2020 Medium

    Showed PPRC1 can be induced through an Akt-independent cAMP/CREB route and can functionally substitute for PGC-1α to rescue mitochondrial homeostasis.

    Evidence Akt3 siRNA depletion, sildenafil and CREB pathway inhibition in primary endothelial cells, oxygen consumption, mtDNA, VDAC and angiogenesis assays

    PMID:33087445

    Open questions at the time
    • Direct CREB binding to the PPRC1 locus not demonstrated
    • Mechanism of PGC-1α functional substitution not detailed
  8. 2020 Low

    Correlated PPRC1 expression with mitochondrial protein levels more tightly than PGC-1α, positioning PPRC1 as a primary maintainer of mitochondrial biogenesis in fibroblasts.

    Evidence Correlation of PPRC1/PGC-1α mRNA with TFAM and SDHA protein across cell lines, plus PGC-1α knockdown

    PMID:32639509

    Open questions at the time
    • Correlational design without direct PPRC1 manipulation
    • Causality between PPRC1 and TFAM/SDHA not established
  9. 2021 Low

    Implicated PPRC1 in a cancer-associated migration/metastasis pathway as part of a predicted COL5A1-PPRC1-ESM1 axis.

    Evidence Transcriptomics of COL5A1-overexpressing GBM cells, ingenuity pathway analysis, cell mobility and actin polymerization assays

    PMID:34702798

    Open questions at the time
    • Largely computational pathway inference
    • Direct PPRC1 manipulation in the migration phenotype not performed
  10. 2021 Low

    Linked PPRC1 to a human disease by identifying a point mutation in a family with premature ovarian failure and a possible role in granulosa cell apoptosis.

    Evidence Whole exome and Sanger sequencing of a Chinese POF family, PPRC1 overexpression in COV434 granulosa cells, apoptosis and senescence assays

    PMID:33818872

    Open questions at the time
    • Single family without functional validation of the mutation's pathogenicity
    • Mechanism connecting PPRC1 to granulosa cell apoptosis unresolved
  11. 2025 Low

    Implicated PPRC1 in AML cell survival via its mitochondrial biogenesis role, with pharmacological downregulation promoting mitochondrial apoptosis.

    Evidence Eugenol treatment of AML cell lines/primary cells, immunoblotting, qRT-PCR, membrane potential and apoptosis assays

    PMID:39996733

    Open questions at the time
    • Effect inferred from drug treatment rather than direct PPRC1 perturbation
    • Mechanism of selective dependence in AML not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • The direct DNA-binding transcription factors and coactivation complexes through which PPRC1 activates respiratory and stress-response gene programs remain unidentified.
  • No structural model of PPRC1 or its activation domains
  • Genome-wide PPRC1 occupancy and direct target promoters not mapped
  • Priming kinase upstream of GSK-3 phosphorylation unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 2
Localization
GO:0005634 nucleus 2
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-1852241 Organelle biogenesis and maintenance 2 R-HSA-74160 Gene expression (Transcription) 2 R-HSA-8953897 Cellular responses to stimuli 2
Partners
GSK3BMYCSTAT6

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 Stable shRNA-mediated knockdown of PRC (PPRC1) in U2OS cells caused severe inhibition of respiratory growth, reduced expression of respiratory protein subunits from complexes I, II, III, and IV, markedly lower complex I and IV enzyme activities, diminished mitochondrial ATP production, and a striking proliferation of abnormal mitochondria devoid of organized cristae. Both complete and partial knockdown lines showed reduced growth on glucose and inhibition of G1/S cell cycle progression, establishing PRC as required for mitochondrial respiratory function and cell cycle progression. Lentiviral shRNA knockdown (two independent shRNAs), respiratory enzyme assays, mitochondrial morphology (electron microscopy), ATP production assay, microarray gene expression, cell cycle analysis The Journal of biological chemistry High 19036724
2016 PRC (PPRC1) and c-MYC act in concert through Akt-GSK-3 signaling to reprogram gene expression in response to mitochondrial stress. PRC protein stability is negatively regulated by GSK-3 phosphorylation at two serine residues in its carboxyl-terminal domain; mutation of these sites markedly increased PRC steady-state expression. CCCP-induced mitochondrial uncoupling activated Akt, which phosphorylated and inactivated GSK-3β, thereby increasing PRC protein half-life. The Akt inhibitor MK-2206 blocked CCCP-induced induction of PRC, c-MYC, and PRC-dependent stress genes. c-MYC siRNA silencing and a c-MYC inhibitor each suppressed PRC induction, demonstrating a requirement for c-MYC in the stress program. GSK-3 phosphorylation site mutagenesis, c-MYC siRNA silencing, pharmacological inhibitors (MK-2206 Akt inhibitor, 10058-F4 c-MYC inhibitor, AZD2858 GSK-3 inhibitor, CCCP), protein half-life measurement, reporter assays The Journal of biological chemistry High 27789709
2013 PRC (PPRC1) orchestrates a stress-response inflammatory program that is activated during apoptosis and premature senescence. PRC and its target genes (IL1α, SPRR2D, SPRR2F) were rapidly induced by menadione (apoptosis inducer via intracellular ROS) and this induction was blocked by the antioxidant N-acetylcysteine, placing PRC downstream of intracellular oxidants. The topoisomerase I inhibitor SN-38 also activated the PRC program over an extended, antioxidant-insensitive time course coincident with senescence markers. Meclizine (promotes glycolytic metabolism) potently induced PRC and increased lactate production. c-MYC and PRC were coordinately induced under all conditions tested. Pharmacological induction/inhibition (menadione, SN-38, meclizine, N-acetylcysteine), immunoblotting, senescence-associated β-galactosidase assay, lactate production assay, gene expression analysis The Journal of biological chemistry Medium 23364789
2020 Sildenafil (PDE5 inhibitor) induces PRC (PPRC1) expression through a cAMP/CREB-dependent mechanism independently of Akt3. PRC induction by sildenafil rescued mitochondrial homeostasis defects (decreased uncoupled oxygen consumption, increased fission, decreased membrane potential) caused by Akt3 depletion in primary endothelial cells, and promoted angiogenesis. PRC was shown to functionally substitute for absent PGC-1α activity during mitochondrial stress via this Akt3-independent pathway. Akt3 siRNA depletion, pharmacological inhibition (sildenafil, Akt3 inhibitor, paraquat), oxygen consumption measurement, mitochondrial DNA content, VDAC protein expression, CREB pathway inhibition, angiogenesis assays The Journal of biological chemistry Medium 33087445
2013 Overexpression of PRC (PPRC1) in human umbilical vein endothelial cells attenuated LPS-induced monocyte adhesion, decreased VCAM-1 and E-selectin expression, protected mitochondrial metabolic function, suppressed glycolysis, and decreased NF-κB transcriptional activity. LPS inhibited endogenous PRC expression, and PRC overexpression reversed these LPS-induced pro-inflammatory effects. PRC overexpression in HUVECs, monocyte adhesion assay, VCAM-1/E-selectin immunoblotting, NF-κB reporter assay, mitochondrial metabolic assays Biochemical and biophysical research communications Medium 23954632
2014 PRC (PPRC1) expression was induced in M2-polarized microglia. Overexpression of PRC promoted M2 polarization (increased Arg1, Fizz1, Ym1 expression), while PRC silencing attenuated M2 polarization. Mechanistically, PRC was found to cooperate with the transcription factor STAT6 to induce the M2 gene program. PRC overexpression and siRNA silencing in microglia, qRT-PCR for M2 marker genes, co-immunoprecipitation/co-operation assay with STAT6 Journal of molecular neuroscience Medium 24838382
2015 Male Pprc1 heterozygous knockout mice on a high-fat diet showed resistance to diet-induced obesity with decreased adipose tissue and elevated energy expenditure. In skeletal muscle, Pprc1 showed haploinsufficiency with down-regulation of Pgc1b and Pgc1a. In adipose tissue, compensatory increases in other Pgc1 family members drove up-regulation of respiratory chain genes. These results established an in vivo role for Pprc1 in controlling mitochondrial gene expression and energy metabolic processes. Heterozygous Pprc1 knockout mouse model, high-fat diet challenge, metabolic phenotyping (energy expenditure, adipose tissue mass), gene expression analysis of PGC family members and respiratory chain genes Endocrine journal Medium 25994039
2020 In human dermal fibroblasts, PPRC1 expression level directly correlated with the expression of mitochondrial proteins TFAM and SDHA across 10 cell lines, whereas PGC-1α expression did not show this correlation. This establishes PPRC1 as more tightly linked than PGC-1α to mitochondrial biogenesis maintenance in fibroblasts. Correlation analysis of PPRC1 and PGC-1α mRNA with TFAM and SDHA protein levels across multiple cell lines; PGC-1α knockdown with TFAM/MT-CO2 protein measurement Genetics and molecular biology Low 32639509
2021 In a GBM cell model, COL5A1 overexpression activated PPRC1 expression, and PPRC1 was predicted by pathway analysis to act downstream of COL5A1 and upstream of ESM1, forming a COL5A1-PPRC1-ESM1 axis associated with cell mobility, metastatic ability, and actin polymerization status. PPRC1 was identified as a transcription factor or downstream participant in this pathway. Transcriptomics dataset from COL5A1-overexpressing cells, ingenuity pathway analysis (IPA), cell mobility and actin polymerization assays Cell death discovery Low 34702798
2025 Eugenol downregulated PPRC1 at both protein and mRNA levels in AML cell lines and reduced mitochondrial membrane potential, promoting apoptosis through the mitochondrial pathway. PPRC1 expression was higher in cancer cells than normal cells, and PPRC1 overexpression was shown to be relevant to AML cell survival, implicating PPRC1 as a regulator of mitochondrial biogenesis required for AML cell survival. Eugenol treatment of AML cell lines and primary AML cells, immunoblotting, qRT-PCR, mitochondrial membrane potential assay, apoptosis assay (mitochondrial pathway markers) Cells Low 39996733
2021 A novel point mutation in PPRC1 (c.2902C>T; p.Thr958Ile) was identified in a Chinese family with premature ovarian failure (POF). Overexpression of PPRC1 in COV434 granulosa cells suggested PPRC1 may be involved in regulating granulosa cell apoptosis but not senescence-associated POF development. Whole exome sequencing, Sanger sequencing, PPRC1 overexpression in COV434 granulosa cells, apoptosis assay, senescence staining The journal of gene medicine Low 33818872

Source papers

Stage 0 corpus · 75 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function. Molecular endocrinology (Baltimore, Md.) 222 16339279
1991 Cloning, mapping, and characterization of the Escherichia coli prc gene, which is involved in C-terminal processing of penicillin-binding protein 3. Journal of bacteriology 133 1856173
1996 Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated R1pA. Journal of bacteriology 127 8576052
2006 Cell wall-inhibitory antibiotics activate the alginate biosynthesis operon in Pseudomonas aeruginosa: Roles of sigma (AlgT) and the AlgW and Prc proteases. Molecular microbiology 123 17020580
1996 An amino-terminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activity. Molecular endocrinology (Baltimore, Md.) 90 8923464
2008 Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria. The Journal of biological chemistry 60 19036724
2008 Systematic expression analysis and antibody screening do not support the existence of naturally occurring progesterone receptor (PR)-C, PR-M, or other truncated PR isoforms. Endocrinology 55 18617611
2004 High-level accumulation of a recombinant antibody fragment in the periplasm of Escherichia coli requires a triple-mutant (degP prc spr) host strain. Biotechnology and bioengineering 54 14760686
1997 An N-terminally truncated third progesterone receptor protein, PR(C), forms heterodimers with PR(B) but interferes in PR(B)-DNA binding. The Journal of steroid biochemistry and molecular biology 53 9408082
2004 The PRC-barrel domain of the ribosome maturation protein RimM mediates binding to ribosomal protein S19 in the 30S ribosomal subunits. RNA (New York, N.Y.) 51 15496525
2017 Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc. Nature communications 43 29138488
2012 ROS-scavenger and radioprotective efficacy of the new PrC-210 aminothiol. Radiation research 42 22702647
2005 Prc protease promotes mucoidy in mucA mutants of Pseudomonas aeruginosa. Microbiology (Reading, England) 42 16000715
2013 Spatial and stimulus-type tuning in the LEC, MEC, POR, PrC, CA1, and CA3 during spontaneous item recognition memory. Hippocampus 40 23966131
2021 Type V collagen alpha 1 chain promotes the malignancy of glioblastoma through PPRC1-ESM1 axis activation and extracellular matrix remodeling. Cell death discovery 39 34702798
1994 Deletion of the prc (tsp) gene provides evidence for additional tail-specific proteolytic activity in Escherichia coli K-12. Molecular & general genetics : MGG 35 8159175
2010 Regulation of subtilisin-like protease prC expression by nematode cuticle in the nematophagous fungus Clonostachys rosea. Environmental microbiology 32 20636375
2014 The Prc and RseP proteases control bacterial cell-surface signalling activity. Environmental microbiology 31 24373018
1992 Multiple antibiotic susceptibility associated with inactivation of the prc gene. Journal of bacteriology 30 1447154
2004 Interaction of the Escherichia coli lipoprotein NlpI with periplasmic Prc (Tsp) protease. Journal of biochemistry 29 15047720
2008 Comparison of BGM and PLC/PRC/5 cell lines for total culturable viral assay of treated sewage. Applied and environmental microbiology 28 18326686
2020 Identification of MltG as a Prc Protease Substrate Whose Dysregulation Contributes to the Conditional Growth Defect of Prc-Deficient Escherichia coli. Frontiers in microbiology 25 32973722
2016 Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in the Stress Response to Mitochondrial Dysfunction. The Journal of biological chemistry 24 27789709
1999 MET(PRC) mutations in the Ron receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potential. Journal of cellular physiology 24 10528237
2014 The periplasmic PDZ domain-containing protein Prc modulates full virulence, envelops stress responses, and directly interacts with dipeptidyl peptidase of Xanthomonas oryzae pv. oryzae. Molecular plant-microbe interactions : MPMI 23 24200074
2020 The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli. Journal of biomedical science 22 31900139
2014 Salinity-dependent impacts of ProQ, Prc, and Spr deficiencies on Escherichia coli cell structure. Journal of bacteriology 22 24443528
2022 A Cell Wall Hydrolase MepH Is Negatively Regulated by Proteolysis Involving Prc and NlpI in Escherichia coli. Frontiers in microbiology 21 35418955
2016 Functional characterization and transcriptome analysis reveal multiple roles for prc in the pathogenicity of the black rot pathogen Xanthomonas campestris pv. campestris. Research in microbiology 19 26804425
2013 Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence. The Journal of biological chemistry 19 23364789
1982 Two structurally and functionally different forms of the transforming protein of PRC II avian sarcoma virus. Molecular and cellular biology 19 6290871
2020 PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt3 inhibition by promotion of PRC expression. The Journal of biological chemistry 18 33087445
2010 Expression of a serine protease gene prC is up-regulated by oxidative stress in the fungus Clonostachys rosea: implications for fungal survival. PloS one 18 20976223
2010 The zebrafish genes encoding the Polycomb repressive complex (PRC) 1. Gene 16 21195142
1982 Expression of the PRC II avian sarcoma virus genome. Journal of virology 16 6284969
2007 Efficacy of hydroxyurea (HU) in reduction of pack red cell (PRC) transfusion requirement among children having beta-thalassemia major: Karachi HU trial (KHUT). Journal of pediatric hematology/oncology 15 17984691
2017 Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery. BMJ open 14 28821525
2013 PGC-1-related coactivator (PRC) negatively regulates endothelial adhesion of monocytes via inhibition of NF κB activity. Biochemical and biophysical research communications 13 23954632
2018 Significant Suppression of CT Radiation-Induced DNA Damage in Normal Human Cells by the PrC-210 Radioprotector. Radiation research 12 29781766
2014 PGC-1-related coactivator (PRC) is an important regulator of microglia M2 polarization. Journal of molecular neuroscience : MN 12 24838382
1983 Simultaneous measurements of estrogen nuclear (E2Rn) and progestin cytosol (PRc) receptors in the hypothalamus and pituitary gland of rats. Journal of receptor research 12 6672190
2012 Splice variant PRKC-ζ(-PrC) is a novel biomarker of human prostate cancer. British journal of cancer 10 22644296
2020 Significant Improvement in Rat Kidney Cold Storage Using UW Organ Preservation Solution Supplemented With the Immediate-Acting PrC-210 Free Radical Scavenger. Transplantation direct 9 33134502
2019 Significant Reduction of Murine Renal Ischemia-Reperfusion Cell Death Using the Immediate-Acting PrC-210 Reactive Oxygen Species Scavenger. Transplantation direct 9 31334343
2019 Significant reduction of ischemia-reperfusion cell death in mouse myocardial infarcts using the immediate-acting PrC-210 ROS-scavenger. Pharmacology research & perspectives 9 31338199
2013 Increased bile resistance in Salmonella enterica mutants lacking Prc periplasmic protease. International microbiology : the official journal of the Spanish Society for Microbiology 9 24400526
2014 Association of Deficiency of Coagulation Factors (Prs, Prc, ATIII) and FVL Positivity with Preeclampsia and/or Eclampsia in Pregnant Women. International journal of hematology-oncology and stem cell research 8 25774262
1998 A PRC based model of a pacemaker cell: effect of vagal activity and investigation of the respiratory sinus arrhythmia. Journal of theoretical biology 8 9637059
1990 Characteristics of Parker's rat coronavirus (PRC) replicated in L-2 cells. Archives of virology 8 2378568
2022 OmpR and Prc contribute to switch the Salmonella morphogenetic program in response to phagosome cues. Molecular microbiology 7 36115022
2018 Reduction of X-ray-induced DNA damage in normal human cells treated with the PrC-210 radioprotector. Biology open 7 30135082
2023 NlpI-Prc Proteolytic Complex Mediates Peptidoglycan Synthesis and Degradation via Regulation of Hydrolases and Synthases in Escherichia coli. International journal of molecular sciences 6 38003545
2021 Suppression of Inflammation-Associated Kidney Damage Post-Transplant Using the New PrC-210 Free Radical Scavenger in Rats. Biomolecules 6 34356678
2015 Resistance to high-fat diet-induced obesity in male heterozygous Pprc1 knockout mice. Endocrine journal 6 25994039
2023 Widespread PRC barrel proteins play critical roles in archaeal cell division. bioRxiv : the preprint server for biology 5 37090588
1996 A new Bacillus subtilis gene with homology to Escherichia coli prc. Gene 5 8996100
2025 Eugenol Promotes Apoptosis in Leukemia Cells via Targeting the Mitochondrial Biogenesis PPRC1 Gene. Cells 4 39996733
2023 The Prc and CtpA proteases modulate cell-surface signaling activity and virulence in Pseudomonas aeruginosa. iScience 4 37534181
2023 PrC-210 Protects against Radiation-Induced Hematopoietic and Intestinal Injury in Mice and Reduces Oxidative Stress. Antioxidants (Basel, Switzerland) 3 37507957
2020 PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts. Genetics and molecular biology 3 32639509
2024 In vivo and in vitro analyses of the role of the Prc protease in inducing mucoidy in Pseudomonas aeruginosa. Journal of bacteriology 2 39287400
2021 Characterization of a Novel Chromosome-Encoded AmpC β-Lactamase Gene, bla PRC-1, in an Isolate of a Newly Classified Pseudomonas Species, Pseudomonas wenzhouensis A20, From Animal Farm Sewage. Frontiers in microbiology 2 34975778
2026 A new sensitive derivatization assay of PrC-210 in plasma and tissues using liquid chromatography coupled with tandem mass spectrometry. Bioanalysis 1 41684060
2025 Periplasmic Serine Protease Prc is Responsible for Amyloid Subunit CsgA Degradation and Proteostasis in Escherichia coli. Journal of molecular biology 1 40907937
2024 Significantly Improved Cold Preservation of Rat Hind Limb Vascularized Composite Allografts Using the New PrC-210 Free Radical Scavenger. International journal of molecular sciences 1 38338887
2024 Significant Reduction of Radiation-Induced Death in Mice Treated with PrC-210 and G-CSF after Irradiation. Radiation research 1 39142656
2021 A novel PPRC1 point mutation in a Chinese family with premature ovarian failure: A case study. The journal of gene medicine 1 33818872
2019 Specific Reconstruction on pRC Plasmid to Facilitate Its Universal Chromosomal Integration in Different Ralstonia solanacearum Species Complex Strains. Molecular plant-microbe interactions : MPMI 1 30958087
2019 Impact of the PrC-210 Radioprotector Molecule on Cancer Deaths in p53-Deficient Mice. Radiation research 1 31738662
2013 [Polymorphism analysis on the genotypes of circumsporozoite protein of Plasmodium vivax with PRC-RFLP]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 1 24818420
1997 [Experimental studies on somatic gene therapy for diabetes. I. Structuring of recombinant from human insulin gene and ammalian expression vector PRC/CMV]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 1 10453511
2025 The PDZ Domain-Containing Protein Prc Is Involved in Virulence and Stress Tolerance in the Poplar Canker Bacterium Lonsdalea populi. Phytopathology 0 40434399
2024 In vivo and in vitro analysis of the role of the Prc protease in inducing mucoidy in Pseudomonas aeruginosa. bioRxiv : the preprint server for biology 0 38854061
2023 Tachycardia and fever after packed red cell (PRC) infusion: A case report. Journal of family medicine and primary care 0 37649762
1999 Inhibition of metastasis to lung of a human nasopharyngeal carcinoma cell line CNE- 2L2 transfected with pRc/ CMV-antisense 6A8 cDNA in nude mice. Science in China. Series C, Life sciences 0 18726475

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