Affinage

PPP2CB

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform · UniProt P62714

Length
309 aa
Mass
35.6 kDa
Annotated
2026-06-10
55 papers in source corpus 18 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PPP2CB encodes the beta isoform of the PP2A serine/threonine phosphatase catalytic subunit and functions as a substrate-selective dephosphorylating enzyme that tunes diverse signaling and chromatin events (PMID:37661576, PMID:21998041). Genetically, PPP2CB is dispensable for gross mouse development, distinguishing it from the embryonic-lethal alpha isoform, and similarly does not drive the mitotic-arrest phenotype attributed to PPP2CA, establishing functional divergence between the two catalytic isoforms (PMID:21998041, PMID:17121919). As a phosphatase it acts on defined substrates: it removes Plk1-installed phosphorylation of the H3K9 methyltransferase G9a at Thr1045 during late mitosis to reactivate G9a and raise H3K9me2 while H3S10 phosphorylation falls, linking PPP2CB to chromatin organization and mitotic progression (PMID:37661576); it dephosphorylates LC3B to weaken the LC3B-OPTN interaction and restrain PINK1/Parkin-mediated mitophagy (PMID:41059761); and it dephosphorylates TBK1, where REGgamma-driven proteasomal degradation of PPP2CB relieves this suppression to sustain TBK1-IRF3 signaling and IFNbeta antiviral responses (PMID:40736577). PPP2CB also restrains growth and activation pathways: it negatively regulates PMA/ionomycin-induced T-cell activation through PI3K/Akt and Ca2+ signaling (PMID:35068054), and in vascular smooth muscle cells it is transcriptionally induced by a YAP1/TEAD1 axis to inhibit AMPK and thereby activate mTORC1 and drive proliferation (PMID:41797917). Additional physical and functional partners reported include GADD45alpha, adenylyl cyclase type 5, and LOX-1, the latter linking PPP2CB to MAPK/ERK-dependent hepatic lipid accumulation (PMID:30151693, PMID:31752385, PMID:40611318).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1993 High

    Establishing the genomic identity and locus of PPP2CB was the prerequisite for distinguishing it from the alpha catalytic isoform and from its pseudogene.

    Evidence FISH, somatic cell hybrid PCR, and Southern blot mapping

    PMID:8383590

    Open questions at the time
    • Mapping alone gives no information on protein function or substrate specificity
    • Does not address tissue expression or isoform-specific roles
  2. 1998 Medium

    An early in vivo link tied PPP2CB expression to adaptive neural plasticity, raising the question of whether this isoform has tissue-specific functional roles.

    Evidence Differential display, in situ hybridization, and okadaic acid infusion with nystagmus behavioral readout in labyrinthectomized rats

    PMID:9840505

    Open questions at the time
    • Okadaic acid is not PP2A-isoform-specific, so the functional attribution to PPP2CB is partial
    • No substrate or molecular mechanism identified in Purkinje cells
  3. 2006 Medium

    Knockdown experiments tested whether PPP2CB drives the PP2A mitotic-arrest phenotype, answering that it does not and thereby separating it functionally from PPP2CA.

    Evidence Antisense oligonucleotide and siRNA knockdown with flow cytometry, live imaging, and immunostaining

    PMID:17121919

    Open questions at the time
    • A negative result that does not define what PPP2CB does in mitosis
    • Does not exclude redundancy with PPP2CA under other conditions
  4. 2011 High

    A clean global knockout resolved whether PPP2CB is essential in vivo, showing it is dispensable for gross development in contrast to the lethal alpha isoform.

    Evidence Cre/loxP global knockout mouse with phenotypic analysis

    PMID:21998041

    Open questions at the time
    • Dispensability under basal conditions does not rule out roles under stress or in specific cell types
    • No molecular substrate implicated
  5. 2012 Medium

    Genetic modeling implicated PPP2CB level as a driver of meiotic arrest, suggesting dosage-sensitive control of oocyte maturation.

    Evidence Marf1-mutant mouse oocyte model with PPP2CB protein expression analysis

    PMID:22442484

    Open questions at the time
    • Direct rescue experiment not detailed
    • Substrate dephosphorylated by elevated PPP2CB in oocytes not identified
  6. 2019 Medium

    Interaction screens and inhibitor pharmacology began to define PPP2CB's binding partners and its catalytic mechanism shared across the PP2A family.

    Evidence BiFC interaction screen with adenylyl cyclase type 5 and cAMP assays; in vitro phosphatase inhibition by LB-100 with PPP5C co-crystal structure

    PMID:30679389 PMID:31752385

    Open questions at the time
    • AC5 interaction lacks reciprocal structural mapping
    • LB-100 catalytic inhibition was inferred for PPP2CB from shared mechanism, not directly crystallized with PPP2CB
  7. 2018 Medium

    Co-IP and AMPK assays linked PPP2CB to GADD45alpha-dependent metabolic protection, embedding it in hepatocyte AMPK signaling.

    Evidence Co-immunoprecipitation (LC-MS/MS) with loss/gain-of-function and AMPK activation assays in vitro and in vivo

    PMID:30151693

    Open questions at the time
    • Single Co-IP without reciprocal validation
    • Whether PPP2CB dephosphorylates an AMPK-pathway substrate directly is not shown
  8. 2022 High

    A T-cell-specific knockout placed PPP2CB as a negative regulator of stimulation-induced activation, defining its pathway context downstream of PMA/ionomycin.

    Evidence T-cell conditional knockout, flow cytometry, PI3K inhibitor rescue, and MS phosphoproteomics

    PMID:35068054

    Open questions at the time
    • Phosphoproteomics identified candidate substrates that were not individually validated
    • Mechanism is selective for PMA/ionomycin and not TCR-induced activation
  9. 2023 High

    Direct dephosphorylation assays identified G9a-pThr1045 as a bona fide PPP2CB substrate, establishing a phosphatase-counterbalance to Plk1 in mitotic chromatin control.

    Evidence In vitro dephosphorylation, Co-IP, phosphomimetic/phospho-null mutagenesis, and chromatin accessibility and cell cycle assays

    PMID:37661576

    Open questions at the time
    • Holoenzyme regulatory subunit conferring G9a specificity not defined
    • Whether this is unique to the beta isoform versus alpha not directly contrasted
  10. 2025 High

    Three converging studies defined PPP2CB substrates and regulation in mitophagy and antiviral immunity, and a transcriptional and lipid-signaling context, broadening its substrate repertoire.

    Evidence Co-IP/PLA and mitophagy flux assays for LC3B; reciprocal Co-IP, REGgamma-deficient mice, and viral infection for TBK1; Co-IP/IF and ApoE-/- mouse for LOX-1/MAPK/ERK

    PMID:40611318 PMID:40736577 PMID:41059761

    Open questions at the time
    • LC3B and LOX-1 findings are single-lab
    • The specific PP2A holoenzyme composition for each substrate is not fully resolved
  11. 2026 Medium

    Transcriptional control by YAP1/TEAD1 was shown to couple PPP2CB expression to AMPK inhibition and mTORC1 activation in proliferating vascular smooth muscle cells.

    Evidence YAP1 silencing/overexpression, TEAD1 reporter/ChIP, AMPK/mTORC1 activity, CAMKK2 requirement, and proliferation assays in human VSMCs

    PMID:41797917

    Open questions at the time
    • Direct AMPK substrate dephosphorylated by PPP2CB not biochemically confirmed
    • Single-lab signaling axis

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how the PP2A regulatory (B) subunits and holoenzyme assembly direct PPP2CB to its distinct substrates (G9a, LC3B, TBK1) across different cell types, and which roles are unique to the beta isoform versus redundant with PPP2CA.
  • No systematic mapping of regulatory subunits to each substrate
  • Isoform-specific versus redundant contributions largely untested in vivo
  • No PPP2CB-specific structure with bound substrate

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016787 hydrolase activity 3 GO:0140096 catalytic activity, acting on a protein 3
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 2 R-HSA-1640170 Cell Cycle 1 R-HSA-4839726 Chromatin organization 1 R-HSA-9612973 Autophagy 1
Partners
ADCY5G9AGADD45ALC3BLOX-1REGGAMMATBK1
Complex memberships
PP2A holoenzyme

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 Suppression of PP2Abeta (PPP2CB) by antisense oligonucleotides or siRNA does NOT induce metaphase arrest or aberrant mitotic spindles, whereas suppression of PP2Aalpha (PPP2CA) is sufficient to induce metaphase arrest with lagging chromosomes. This establishes that PPP2CB is not the isoform responsible for cantharidin-induced mitotic arrest phenotype. Antisense oligonucleotides and siRNA knockdown with flow cytometry, live cell imaging, and immunostaining Molecular cancer therapeutics Medium 17121919
1993 PPP2CB (the beta isoform of the PP2A catalytic subunit) was chromosomally mapped to human chromosome 8p12→p11.2 by fluorescence in situ hybridization using somatic cell hybrids and genomic probes; a pseudogene (PPP2CBP) was identified on chromosome 16 by Southern blot. Somatic cell hybrid PCR, fluorescence in situ hybridization, Southern blot Cytogenetics and cell genetics High 8383590
2011 Homozygous global deletion of Ppp2cb in mice (Ppp2cb Δ/Δ) does not produce any obvious morphological or physiological defects, establishing that PPP2CB is dispensable for gross development in vivo, in contrast to Ppp2ca which causes early embryonic lethality. Conditional knockout mouse (loxP/Cre-mediated deletion), phenotypic analysis Genesis (New York, N.Y. : 2000) High 21998041
2012 Up-regulation of PPP2CB protein is a key mediator of meiotic arrest in MARF1-deficient mouse oocytes; elevated PPP2CB levels are linked to female infertility, defective cytoplasmic maturation, and meiotic arrest in this model. Genetic mouse model (Marf1 mutation), protein expression analysis, phenotypic rescue inference Science (New York, N.Y.) Medium 22442484
2019 PPP2CB (PP2A catalytic subunit beta) was identified as a novel protein-protein interaction partner of adenylyl cyclase type 5 (AC5) in striatal medium spiny neurons using bimolecular fluorescence complementation (BiFC) screening. Knockdown of PPP2CB reduced acute and sensitized adenylyl cyclase activity, implicating PPP2CB as a persistent regulator of adenylyl cyclase/cAMP signaling. Bimolecular fluorescence complementation (BiFC) protein-protein interaction screen, genetic knockdown, cAMP signaling assays in neuronal cell lines and MSNs Cells Medium 31752385
2017 PPP2CB is a direct target of miR-1246 in mesenchymal stem/stromal cells (MSCs); miR-1246-mediated suppression of PPP2CB (along with PRKAR1A) drives NF-κB-dependent pro-inflammatory cytokine production (IL-6, CCL2, CCL5) in MSCs. miRNA overexpression, direct target validation (in vitro), NF-κB activity assays, cytokine measurement Oncotarget Medium 28159925
2019 LB-100 is demonstrated to be a catalytic inhibitor of PP2AC (PPP2CA/PPP2CB) in vitro using purified enzyme inhibition assays; LB-100's 7-oxabicyclo[2.2.1]heptane-2,3-dicarbonyl moiety coordinates with catalytic metal ions conserved in both PP2AC and PPP5C, as revealed by crystal structure of PPP5C co-crystallized with LB-100 at 1.65 Å resolution. In vitro phosphatase inhibition assay with purified enzymes, X-ray crystallography (PPP5C co-crystal at 1.65 Å), cell-based genetic disruption studies Molecular cancer therapeutics Medium 30679389
2018 PPP2CB (catalytic subunit of PP2A) directly interacts with GADD45α as shown by co-immunoprecipitation; GADD45α promotes AMPKα activation in hepatocytes, and this interaction with PPP2CB is proposed as part of the mechanism by which GADD45α protects against acetaminophen-induced liver injury. Co-immunoprecipitation (LC-MS/MS), loss-of-function and overexpression in vitro and in vivo, AMPK activation assays Cellular and molecular life sciences : CMLS Medium 30151693
2022 T cell-specific knockout of PPP2CB (PPP2CBfl/fl Lck-Cre+) showed PPP2CB is dispensable for T-cell development and TCR-induced activation, but PPP2CB specifically suppresses PMA/ionomycin-induced T-cell activation by negatively regulating PI3K/Akt signaling and Ca2+ flux. Mass spectrometry-based phospho-peptide analysis identified potential substrates of PPP2CB during PMA/ionomycin stimulation. T cell-specific conditional knockout mouse, flow cytometry (CD69/CD25 expression, proliferation), cytokine measurement, PI3K inhibitor rescue, MS-based phosphoproteomics The FEBS journal High 35068054
2023 PPP2CB dephosphorylates the H3K9me1/2 methyltransferase G9a at Thr1045 (pT1045) during late mitosis, reactivating G9a catalytic activity and upregulating H3K9me2 levels, correlating with decreased H3S10 phosphorylation. This establishes PPP2CB as the phosphatase that removes Plk1-mediated phosphorylation of G9a to regulate chromatin organization and mitotic progression. Biochemical dephosphorylation assays, co-immunoprecipitation, phosphomimetic/phospho-null mutagenesis, chromatin accessibility assays, cell cycle progression analysis Advanced science (Weinheim, Baden-Wurttemberg, Germany) High 37661576
2025 PPP2CB dephosphorylates LC3B, and this dephosphorylation reduces the interaction between LC3B and the mitophagy receptor OPTN, thereby impeding mitochondrial recruitment of phagophores during PINK1-PRKN/Parkin-mediated mitophagy. PPP2CB was identified as the catalytic subunit (beta isoform) of the heterotrimeric PP2A complex responsible for this LC3B dephosphorylation. Co-immunoprecipitation, proximity ligation assay (PLA), gain/loss-of-function in neuronal cells, mitophagy flux assays, pharmacological rescue Autophagy Medium 41059761
2025 REGγ (proteasome activator) interacts with and promotes proteasome-dependent degradation of PPP2CB. This degradation prevents PPP2CB from dephosphorylating TBK1, thereby sustaining TBK1 phosphorylation and its interaction with IRF3, leading to IFNβ-mediated antiviral signaling activation. IFNβ in turn enhances REGγ expression, forming a positive feedback loop. Co-immunoprecipitation, proteasome degradation assays, genetic REGγ deficiency mouse models, viral infection models, TBK1 phosphorylation/IRF3 interaction assays, IFNβ production measurement Cellular and molecular life sciences : CMLS High 40736577
2026 YAP1 transcriptionally upregulates PPP2CB expression via the transcription factor TEAD1 in vascular smooth muscle cells (VSMCs). PPP2CB in turn inhibits AMPK (with CAMKK2 required upstream), relieving AMPK-mediated suppression of mTORC1 and thereby promoting VSMC proliferation. This defines a YAP1/TEAD1→PPP2CB→AMPK inhibition→mTORC1 activation axis in VSMC phenotypic switching. YAP1 silencing and overexpression in human VSMCs, reporter/ChIP assays (TEAD1), AMPK/mTORC1 activity assays, CAMKK2 requirement assay, proliferation readouts iScience Medium 41797917
2025 PPP2CB directly interacts with lectin-like oxidized LDL receptor-1 (LOX-1) as confirmed by immunofluorescence co-localization and co-immunoprecipitation in hepatic cells. PPP2CB overexpression exacerbates lipid accumulation and LDL uptake via activation of the LOX-1/MAPK/ERK signaling cascade, while PPP2CB silencing mitigates these effects. Co-immunoprecipitation, immunofluorescence co-localization, PPP2CB overexpression/silencing, LDL-C uptake assay, Western blotting for MAPK/ERK activation, ApoE-/- mouse model Lipids in health and disease Medium 40611318
1998 PP2A-beta (PPP2CB) mRNA is up-regulated in cerebellar floccular Purkinje cells within 2 days after unilateral labyrinthectomy in rats. Continuous floccular infusion of okadaic acid (PP2A inhibitor) prolonged vestibular compensation (UL-induced nystagmus), suggesting PPP2CB up-regulation in Purkinje cells contributes to lesion-induced vestibular plasticity. Differential display PCR, in situ hybridization, Northern blot, pharmacological inhibition (okadaic acid floccular infusion) with behavioral readout (nystagmus duration) Acta oto-laryngologica Medium 9840505
2008 PPP2CB mRNA expression is significantly reduced in prostate carcinoma compared to benign prostate tissue, positioning it as a candidate tumor suppressor on chromosome 8p; however, SSCP/sequencing analysis of all 7 coding exons found no tumor-specific mutations in bladder tumors, suggesting loss of expression rather than coding mutation as the mechanism. Quantitative RT-PCR (expression), SSCP analysis and direct sequencing of all coding exons (mutation analysis) Cancer genomics & proteomics / Cancer genetics and cytogenetics Low 18460741 9078303
2023 Quantum-based hybrid (ONIOM) calculations on 39-residue models of PP2A(PPP2R5D/PPP2CA or PPP2CB) indicate that bidentate binding of the conserved Arg89 in the catalytic subunit to the substrate phosphate group is critical for optimal dephosphorylation, with activation barrier ΔH‡ ≈ +15.5 kcal/mol (bidentate) vs. +18.8 kcal/mol (Arg89 sequestered by salt bridge with B:Glu198). Quantum mechanics/molecular mechanics (ONIOM UB3LYP/6-31G(d):UPM7) computational modeling of catalytic mechanism Frontiers in cell and developmental biology Low 37377738

Source papers

Stage 0 corpus · 55 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. The Journal of pathology 281 14517837
2012 MARF1 regulates essential oogenic processes in mice. Science (New York, N.Y.) 83 22442484
2018 Coding mutations in NUS1 contribute to Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 79 30348779
2017 miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A. Oncotarget 63 28159925
2006 Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays. British journal of cancer 58 17146477
2013 MRNA and miRNA expression patterns associated to pathways linked to metal mixture health effects. Gene 55 24080485
2019 The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C. Molecular cancer therapeutics 50 30679389
2011 Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse. Genesis (New York, N.Y. : 2000) 46 21998041
2006 Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2Aalpha. Molecular cancer therapeutics 45 17121919
2019 Plasma-derived exosomal miR-183 associates with protein kinase activity and may serve as a novel predictive biomarker of myocardial ischemic injury. Experimental and therapeutic medicine 39 31258652
2019 Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening. Cells 38 31752385
2008 Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer. Cancer genomics & proteomics 35 18460741
1996 Integrated map of the chromosome 8p12-p21 region, a region involved in human cancers and Werner syndrome. Genomics 35 8786118
1993 Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively. Cytogenetics and cell genetics 31 8383590
2022 Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association 30 35142023
2015 Ppp2ca knockout in mice spermatogenesis. Reproduction (Cambridge, England) 30 25628439
1997 Mutation analysis of 8p genes POLB and PPP2CB in bladder cancer. Cancer genetics and cytogenetics 27 9078303
2019 Hsp40 Protein DNAJB6 Interacts with Viral NS3 and Inhibits the Replication of the Japanese Encephalitis Virus. International journal of molecular sciences 22 31739611
2007 Isolation and characterization of okadaic acid binding proteins from the marine sponge Halichondria okadai. Biochemistry 21 17867706
2014 Resolving tumor heterogeneity: genes involved in chordoma cell development identified by low-template analysis of morphologically distinct cells. PloS one 20 24503940
2021 The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer. Bioscience reports 19 33270085
2008 Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye. Molecular vision 19 18432318
2012 Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells. Journal of proteomics 18 22282019
2009 Complex phosphatase regulation of Ca2+-activated Cl- currents in pulmonary arterial smooth muscle cells. The Journal of biological chemistry 16 19767392
2019 Novel Y Chromosome Retrocopies in Canids Revealed through a Genome-Wide Association Study for Sex. Genes 15 31027231
2022 Pulmonary Mesenchymal Stem Cells in Mild Cases of COVID-19 Are Dedicated to Proliferation; In Severe Cases, They Control Inflammation, Make Cell Dispersion, and Tissue Regeneration. Frontiers in immunology 13 35095855
2021 Wnt pathway-related three-mRNA clinical outcome signature in bladder urothelial carcinoma: computational biology and experimental analyses. Journal of translational medicine 13 34579753
2019 Proteomic Maps of Human Gastrointestinal Stromal Tumor Subgroups. Molecular & cellular proteomics : MCP 13 30804049
2008 Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells. Journal of cancer research and clinical oncology 13 18536936
2018 GADD45α alleviates acetaminophen-induced hepatotoxicity by promoting AMPK activation. Cellular and molecular life sciences : CMLS 12 30151693
2016 Serine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct. American journal of physiology. Renal physiology 11 27784696
2023 Secreted miR-210-3p, miR-183-5p and miR-96-5p reduce sensitivity to docetaxel in prostate cancer cells. Cell death discovery 10 38065937
2022 Protein phosphatase 2A catalytic subunit β suppresses PMA/ionomycin-induced T-cell activation by negatively regulating PI3K/Akt signaling. The FEBS journal 10 35068054
2021 The association of immunosurveillance and distant metastases in colorectal cancer. Journal of cancer research and clinical oncology 9 34476575
2023 Striatins and STRIPAK complex partners in clinical outcomes of patients with breast cancer and responses to drug treatment. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 8 37691891
2023 Dynamic Phosphorylation of G9a Regulates its Repressive Activity on Chromatin Accessibility and Mitotic Progression. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 7 37661576
2019 Lineage-negative lymphoma with a helper innate lymphoid cell phenotype. Virchows Archiv : an international journal of pathology 7 31522287
1998 An implication of protein phosphatase 2A-beta in the rat flocculus for lesion-induced vestibular plasticity. Acta oto-laryngologica 7 9840505
2022 Characterization of a Read-through Fusion Transcript, BCL2L2-PABPN1, Involved in Porcine Adipogenesis. Genes 6 35327999
2019 A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease. Nephrology (Carlton, Vic.) 6 31464346
2025 Transcriptomic profiles of single-cell autophagy-related genes (ATGs) in lung diseases. Cell biology and toxicology 5 39920481
2020 The mRNA landscape profiling reveals potential biomarkers associated with acute kidney injury AKI after kidney transplantation. PeerJ 5 33312771
2025 Phillyrin for sepsis-related acute lung injury: A potential strategy suppressing GSK-3β. Molecular immunology 3 40359720
2024 Proteomic analysis of plasma and duodenal tissue in celiac disease patients reveals potential noninvasive diagnostic biomarkers. Scientific reports 3 39622892
2023 Quantum-based modeling implies that bidentate Arg89-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation. Frontiers in cell and developmental biology 3 37377738
2025 Adaptation of Diqing Tibetan pigs to hypoxic and cold environments through extramedullary hematopoiesis and uncoupled thermogenesis in the liver. BMC biology 2 40598433
2025 PPP2CB aggravates atherosclerosis-related dyslipidemia via LOX-1/MAPK/ERK signaling pathway. Lipids in health and disease 2 40611318
2025 PPP2/PP2A-mediated dephosphorylation of LC3B links PINK1-PRKN/Parkin-mediated mitophagy to SCA12 pathogenesis. Autophagy 2 41059761
2024 Identification of reproduction-related genes in the hypothalamus of sheep (Ovis aries) using the nanopore full-length transcriptome sequencing technology. Scientific reports 1 39537852
1997 A 2.8 megabase YAC contig spanning D8S339, which is tightly linked to the Werner syndrome locus. Genome 1 9061915
2026 PP2A dysfunction mediated by PPP2R1A deficiency drives cGAS-STING-dependent hyperinflammation in SLE CD14+ monocytes. Clinical rheumatology 0 41582267
2026 Transcriptional control of PPP2CB by YAP1 and TEAD1 mediates AMPK inhibition and mTORC1 activation in vascular smooth muscle cells. iScience 0 41797917
2026 Glycolytic-Cholesterol Subtypes of Severe Asthma Reveal Distinct Immune-Inflammatory and Metabolic Phenotypes. Journal of inflammation research 0 41940036
2025 REGγ regulates antiviral response by activating TBK1-IFNβ signaling through degradation of PPP2CB. Cellular and molecular life sciences : CMLS 0 40736577
2023 [Circular RNA hsa_circ_0087893 participates in intraventricular hemorrhage occurrence and progression possibly as a competitive endogenous RNA in preterm infants]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 0 37313816

Missed literature

Know a paper Affinage missed for PPP2CB? Flag it for the maintainers and the community.

No submissions yet.