Affinage

PMPCB

Mitochondrial-processing peptidase subunit beta · UniProt O75439

Length
489 aa
Mass
54.4 kDa
Annotated
2026-06-10
65 papers in source corpus 15 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PMPCB encodes the catalytic beta-subunit of the heterodimeric mitochondrial processing peptidase (MPP), the matrix metalloendopeptidase that cleaves N-terminal targeting presequences from nuclear-encoded mitochondrial precursor proteins (PMID:8132665, PMID:8106471, PMID:29576218). MPP activity is obligately heterodimeric: neither the alpha- nor the beta-subunit alone is proteolytically active, and the two must associate to reconstitute processing (PMID:8132665, PMID:8106471). Catalysis resides in PMPCB, whose HXXEH metal-binding motif is essential — individual substitution of either histidine or the glutamate abolishes activity (PMID:7490252) — and which coordinates approximately one zinc atom per molecule; removal of zinc yields an inactive apoenzyme that is restored by nanomolar Zn2+, while excess Zn2+ competitively inhibits the enzyme (PMID:9654444). Functional partitioning between the subunits is well defined: the alpha-subunit binds and presents the presequence, undergoing a substrate-induced conformational change, whereas PMPCB contacts the substrate near the scissile bond and performs cleavage (PMID:9299349, PMID:11031253, PMID:11368022). Loss of PMPCB activity causes accumulation of unprocessed precursors, including the sensitive frataxin processing intermediate, impairing iron-sulfur cluster biogenesis and Fe-S-dependent respiratory chain complex activity; biallelic loss-of-function PMPCB variants cause a human neurodegenerative disorder (PMID:29576218). Consistent with this, vertebrate pmpcb loss collapses mitochondrial membrane potential and ATP synthesis, elevates ROS and ER stress, triggers apoptosis, and impairs WNT/beta-catenin signaling, producing CNS and myelination defects (PMID:41999531). In hepatocellular carcinoma cells, PMPCB is required for mitochondrial homeostasis, and its knockdown suppresses Wnt/beta-catenin signaling via mitochondrial ROS and enhances PINK1-Parkin signaling (PMID:30862714, PMID:31337603).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1994 High

    Established that MPP proteolytic activity requires both subunits, defining the enzyme as an obligate heterodimer rather than a single-chain peptidase.

    Evidence In vitro reconstitution from separately expressed E. coli fusion proteins with precursor processing assays and EDTA inhibition

    PMID:8106471 PMID:8132665

    Open questions at the time
    • Did not localize the catalytic residues to a specific subunit
    • Did not resolve which subunit binds substrate
  2. 1995 High

    Identified PMPCB as the catalytic subunit by showing the HXXEH motif is indispensable for processing.

    Evidence Site-directed mutagenesis of HXXEH histidines and glutamate with co-expression and activity assay

    PMID:7490252

    Open questions at the time
    • Did not establish the metal cofactor identity
    • Did not map subunit interaction surfaces
  3. 1997 High

    Mapped beta-MPP regions controlling active-site conformation and subunit association, and confirmed alpha-MPP as the substrate-binding subunit.

    Evidence Alanine-insertion mutagenesis, Ni-affinity co-purification, surface plasmon resonance and cross-linking

    PMID:9299349

    Open questions at the time
    • No atomic structure of the heterodimer
    • Precise cleavage-site recognition determinants unresolved
  4. 1998 High

    Defined MPP as a zinc metallopeptidase and quantified PMPCB's single-zinc requirement for catalysis.

    Evidence Metal content measurement, apoenzyme preparation and Zn2+ reconstitution, chelator inhibition kinetics

    PMID:9654444

    Open questions at the time
    • Catalytic mechanism at the scissile bond not structurally defined
  5. 1998 High

    Delineated how alpha-MPP recognizes presequences, identifying C-terminal and acidic residues that engage basic residues distal to the cleavage site.

    Evidence Truncation and site-directed mutagenesis of yeast alpha-MPP with processing assays on multiple substrates

    PMID:9737975

    Open questions at the time
    • Substrate specificity rules for the full precursor repertoire not derived
  6. 2001 Medium

    Provided biophysical evidence that substrate binding induces conformational change in alpha-MPP but not beta-MPP, and that beta-MPP contacts substrate near the cleavage site.

    Evidence Tryptophan fluorescence lifetime analysis and FRET with labeled synthetic peptide substrates

    PMID:11031253 PMID:11368022

    Open questions at the time
    • Single-lab biophysical methods without structural confirmation
    • Dynamics during catalytic turnover not captured
  7. 2018 High

    Connected PMPCB loss-of-function to human disease, linking reduced MPP activity to precursor accumulation, impaired Fe-S cluster biogenesis and neurodegeneration.

    Evidence Patient fibroblast processing assays, iPSC-derived neuroepithelial cells, yeast Mas1 complementation, respiratory chain assays

    PMID:29576218

    Open questions at the time
    • Neuron-specific vulnerability mechanism not fully resolved
    • Genotype-phenotype correlation across variants incomplete
  8. 2019 Medium

    Extended PMPCB function to cancer cell mitochondrial homeostasis, showing knockdown drives ROS-dependent suppression of Wnt/beta-catenin and enhanced PINK1-Parkin pro-apoptotic signaling.

    Evidence Genome-wide RNAi screen and shRNA knockdown in HCC cell lines with ROS, signaling, PINK1-Parkin/MCL-1 readouts and in vivo tumor models

    PMID:30862714 PMID:31337603

    Open questions at the time
    • Whether effects are due to loss of MPP catalytic activity versus a moonlighting role unresolved
    • Direct substrate driving the signaling phenotype not identified
  9. 2026 High

    Established a vertebrate in vivo phenotype, showing pmpcb loss causes neural and myelin defects through coupled mitochondrial dysfunction, ER stress, ROS and impaired WNT signaling, each pathway partially rescuable.

    Evidence Zebrafish pmpcb knockout with membrane potential, ATP, ROS, ER stress, apoptosis, WNT assays, and pharmacological/transgenic rescue

    PMID:41999531

    Open questions at the time
    • Relative contribution of each downstream pathway to neurodegeneration not quantified
    • Precursor substrates mediating CNS phenotype not mapped

Open questions

Synthesis pass · forward-looking unresolved questions
  • The full repertoire of physiological PMPCB substrates and the structural basis of beta-subunit cleavage near the scissile bond remain to be defined.
  • No atomic-resolution structure of the human MPP heterodimer in the timeline
  • Substrate-specific determinants of disease vulnerability undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 3 GO:0016787 hydrolase activity 2
Localization
GO:0005739 mitochondrion 2
Pathway
R-HSA-392499 Metabolism of proteins 2
Partners
PMPCA
Complex memberships
Mitochondrial processing peptidase (MPP)

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 Both alpha- and beta-MPP subunits are required for MPP proteolytic activity; neither subunit alone shows processing activity. The beta-MPP subunit is necessary for catalysis while alpha-MPP contributes to substrate recognition. In vitro reconstitution from separately expressed E. coli fusion proteins; EDTA inhibition; processing assay with mitochondrial precursor substrates The Journal of biological chemistry High 8106471 8132665
1995 The HXXEH metal-binding motif in beta-MPP (PMPCB) is essential for MPP catalytic activity. Individual mutation of each histidine or glutamic acid in this motif (to arginine or glutamine) completely abolished processing activity, establishing beta-MPP as the catalytic subunit. Site-directed mutagenesis of HXXEH residues; co-expression of mutant beta-MPP with alpha-MPP in E. coli; processing activity assay Journal of biochemistry High 7490252
1997 Alanine-insertion mutagenesis of beta-MPP identified that the HXXEHX76H region is important for proper active site conformation and may contact alpha-MPP; the non-conserved central region around Lys215 and the C-terminal region around Ser314 are also required for catalysis, with the Lys215 region specifically mediating subunit association. Additionally, purified alpha-MPP (but not beta-MPP) can bind precursor protein substrates, indicating alpha-MPP is the substrate-binding subunit. Alanine insertion mutagenesis along beta-MPP polypeptide; Ni-affinity co-purification to assess alpha/beta subunit association; surface plasmon resonance with peptide substrates; cross-linking Journal of molecular biology High 9299349
1998 MPP is a zinc metallopeptidase; beta-MPP (PMPCB) contains approximately one zinc atom per molecule. A mutation in the first histidine of the HXXEH motif in beta-MPP results in loss of zinc binding (<0.2 atoms Zn2+ per molecule) and abolishes activity. Removal of zinc yields an inactive apoenzyme, and readdition of Zn2+ at nanomolar concentrations restores activity. Excess Zn2+ competitively inhibits the enzyme (Ki 3.1 µM). Metal content measurement of purified MPP and beta-MPP; apoenzyme preparation and metal reconstitution; chelator inhibition kinetics; processing activity assay Journal of molecular biology High 9654444
1998 The C-terminal region of alpha-MPP (last 41 amino acids) is required for both alpha/beta subunit association and processing activity. Specific acidic residues in conserved regions of alpha-MPP (Glu353, Glu377, Asp378) are required for processing of certain substrates depending on presequence length, establishing that alpha-MPP functions as a substrate-recognizing subunit that interacts with basic amino acid residues distal to the cleavage site in precursors with longer extension peptides. Truncation and site-directed mutagenesis of yeast alpha-MPP; recombinant expression; processing assays with multiple precursor substrates (malate dehydrogenase, aspartate aminotransferase, adrenodoxin) The Journal of biological chemistry High 9737975
1999 MPP subunits from different species (yeast, rat, Neurospora crassa) can complement each other in trans: rat or Neurospora beta-MPP can fully substitute for defective yeast beta-MPP (mif1 mutant) both in vivo and in vitro, but rat or Neurospora alpha-MPP cannot substitute for yeast alpha-MPP (mif2 mutant). Only combinations of yeast alpha-MPP with rat or Neurospora beta-MPP produce active enzyme. In vivo complementation of temperature-sensitive yeast mif1 and mif2 mutants; in vitro mixing of individually expressed subunits from three species Archives of biochemistry and biophysics High 10496979
2000 FRET measurements show that when presequence peptide substrates of different lengths are bound to MPP, the N-terminal portion and the portion around the cleavage site interact with specific fixed sites in the MPP molecule, with a flexible intervening sequence. Intermolecular FRET from beta-MPP to substrate confirms beta-MPP contacts the substrate near the cleavage site. Fluorescence resonance energy transfer (FRET) with labeled synthetic peptide substrates of varying lengths bound to MPP; intramolecular and intermolecular FRET measurements The Journal of biological chemistry Medium 11031253
2001 Substrate binding induces a conformational change in the alpha-MPP subunit but not in the beta-MPP subunit, as shown by tryptophan fluorescence lifetime analysis. This supports the model that alpha-MPP is the substrate-binding subunit. Lifetime analysis of tryptophan fluorescence of isolated alpha- and beta-MPP subunits of yeast MPP in the presence and absence of substrate Archives of biochemistry and biophysics Medium 11368022
2018 Biallelic loss-of-function variants in PMPCB cause reduced MPP proteolytic activity, leading to accumulation of the frataxin processing intermediate (a sensitive MPP substrate), impaired iron-sulfur cluster biogenesis, reduced activity of Fe-S cluster-containing respiratory chain complexes, and neurodegeneration. Introduction of patient PMPCB variants into the yeast homolog Mas1 caused a severe growth defect and accumulation of mitochondrial precursor proteins. Patient fibroblast mitochondrial isolation and precursor protein processing assay; iPSC-derived neuroepithelial stem cells; yeast Mas1 complementation with patient variants; respiratory chain complex activity assays in biopsy material American journal of human genetics High 29576218
2019 PMPCB is required for mitochondrial homeostasis in EpCAM+ hepatocellular carcinoma cells. PMPCB knockdown suppresses EpCAM expression and Wnt/β-catenin signaling via mitochondria-related reactive oxygen species production and FOXO activity, resulting in apoptosis and tumor suppression. Genome-wide RNAi screen; shRNA knockdown of PMPCB in HCC cell lines; ROS measurement; Wnt/β-catenin signaling assays; in vivo tumor models Cancer research Medium 30862714
2019 PMPCB silencing sensitizes HCC tumor cells to sorafenib by enhancing PINK1-Parkin signaling and downregulating the anti-apoptotic protein MCL-1, promoting a pro-apoptotic phenotype. shRNA knockdown of PMPCB in murine and human HCC cell lines; sorafenib combination treatment; PINK1-Parkin pathway protein analysis; MCL-1 knockdown rescue experiments; in vivo tumor-bearing mouse model Molecular therapy Medium 31337603
2026 Zebrafish pmpcb knockout (pmpcb-/-) leads to reduced neural cells, uncompacted myelin, and locomotor deficits. Mechanistically, pmpcb deficiency decreases mitochondrial membrane potential, reduces ATP synthesis, elevates ROS and ER stress, causes neural cell apoptosis, and impairs WNT/β-catenin signaling. Rescue with WNT agonist BIO, ATP precursor creatine, ER stress scavenger PBA, or glial-specific pmpcb transgene each partially rescued CNS defects. Zebrafish pmpcb knockout; mitochondrial membrane potential assay; ATP measurement; ROS assay; ER stress markers; apoptosis assay; WNT/β-catenin pathway analysis; pharmacological rescue; transgenic rescue (Tg(gfap:pmpcb)) Molecular neurobiology High 41999531
2022 Depletion of mitochondrial processing peptidase subunits alpha (Pmpca) and beta (Pmpcb) in murine breast cancer cell lines led to a disadvantage in cell growth linked to mitochondrial dysfunction. RNA interference degradome screen; individual knockdown validation in murine breast cancer cell lines; cell growth assay; mitochondrial function assessment Frontiers in oncology Low 36313646
2024 PMPCB protein localizes to the mitochondrial matrix (detected by PMPCB immunostaining as a matrix marker), and colocalization analysis between outer mitochondrial membrane marker TOMM20 and PMPCB reveals that mitochondrial subcompartment integrity is disrupted in female FXS mice compared to wildtype, demonstrating PMPCB's utility as a matrix compartment marker and indicating disrupted mitochondrial architecture in FXS auditory neurons. Immunofluorescence co-staining with TOMM20 (outer membrane) and PMPCB (matrix) in brain slices; colocalization analysis; quantitative fluorescence microscopy bioRxivpreprint Low bio_10.1101_2024.07.02.601649

Source papers

Stage 0 corpus · 65 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Genomes of marine cyanopodoviruses reveal multiple origins of diversity. Environmental microbiology 87 23320838
2018 Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood. American journal of human genetics 79 29576218
1994 Characterization of the mitochondrial processing peptidase of Neurospora crassa. The Journal of biological chemistry 75 8106471
2015 Distinct methylation patterns in genes that affect mitochondrial function are associated with kidney disease in blood-derived DNA from individuals with Type 1 diabetes. Diabetic medicine : a journal of the British Diabetic Association 54 25850930
1994 Rat liver mitochondrial processing peptidase. Both alpha- and beta-subunits are required for activity. The Journal of biological chemistry 53 8132665
1995 A putative metal-binding site in the beta subunit of rat mitochondrial processing peptidase is essential for its catalytic activity. Journal of biochemistry 51 7490252
1997 Functional cooperation of the mitochondrial processing peptidase subunits. Journal of molecular biology 50 9299349
1993 Molecular cloning of a novel isotype of Mg(2+)-dependent protein phosphatase beta (type 2C beta) enriched in brain and heart. Archives of biochemistry and biophysics 48 8274020
2015 Comparative Genomic and Phylogenomic Analyses Reveal a Conserved Core Genome Shared by Estuarine and Oceanic Cyanopodoviruses. PloS one 42 26569403
1996 The mitochondrial processing peptidase: function and specificity. Experientia 39 8988249
2020 Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Development (Cambridge, England) 35 32376682
1998 Role of alpha-subunit of mitochondrial processing peptidase in substrate recognition. The Journal of biological chemistry 35 9737975
1985 Separate site(s) of action of optical isomers of 1-methyl-5-phenyl-5-propylbarbituric acid with opposite pharmacological activities at the GABA receptor complex. European journal of pharmacology 35 2990963
2018 The regulation mechanisms of soluble starch and glycerol for production of azaphilone pigments in Monascus purpureus FAFU618 as revealed by comparative proteomic and transcriptional analyses. Food research international (Ottawa, Ont.) 33 29579968
1999 Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors. Anesthesiology 32 10360870
2020 Investigation of the mycelial morphology of Monascus and the expression of pigment biosynthetic genes in high-salt-stress fermentation. Applied microbiology and biotechnology 31 31993704
2019 Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease. Experimental neurobiology 31 31308798
1999 Depressant and convulsant barbiturates both inhibit neuronal nicotinic acetylcholine receptors. Anesthesia and analgesia 30 10357353
1998 The mitochondrial processing peptidase behaves as a zinc-metallopeptidase. Journal of molecular biology 30 9654444
1995 Molecular cloning and expression of mouse mg(2+)-dependent protein phosphatase beta-4 (type 2C beta-4). Archives of biochemistry and biophysics 30 7733667
2025 Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression. Cells 29 40497970
2015 Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface. The Journal of biological chemistry 28 26229099
1985 GABA, depressants and chloride ions affect the rate of dissociation of 35S-t-butylbicyclophosphorothionate binding. Life sciences 28 2999541
2017 Comparison of αβδ and αβγ GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacological research 25 29294355
2016 Effects of blue light on pigment biosynthesis of Monascus. Journal of microbiology (Seoul, Korea) 25 27033206
2000 A proposed common structure of substrates bound to mitochondrial processing peptidase. The Journal of biological chemistry 23 11031253
2019 Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM+ Hepatocellular Carcinoma. Cancer research 22 30862714
2021 Inducing red pigment and inhibiting citrinin production by adding lanthanum(III) ion in Monascus purpureus fermentation. Applied microbiology and biotechnology 21 33576885
2006 A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria. Journal of bacteriology 20 17158683
2023 Leigh Syndrome: Spectrum of Molecular Defects and Clinical Features in Russia. International journal of molecular sciences 19 36675121
2021 Effects of parental environmental copper stress on offspring development: DNA methylation modification and responses of differentially methylated region-related genes in transcriptional expression. Journal of hazardous materials 18 34801305
2022 Effect of γ-Heptalactone on the Morphology and Production of Monascus Pigments and Monacolin K in Monascus purpureus. Journal of fungi (Basel, Switzerland) 17 35205931
2021 Immune-Omics Networks of CD27, PD1, and PDL1 in Non-Small Cell Lung Cancer. Cancers 17 34503105
2019 PMPCB Silencing Sensitizes HCC Tumor Cells to Sorafenib Therapy. Molecular therapy : the journal of the American Society of Gene Therapy 17 31337603
2013 An Advanced System of the Mitochondrial Processing Peptidase and Core Protein Family in Trypanosoma brucei and Multiple Origins of the Core I Subunit in Eukaryotes. Genome biology and evolution 17 23563972
2008 Antisense RNA inhibition of the beta subunit of the Dictyostelium discoideum mitochondrial processing peptidase induces the expression of mitochondrial proteins. Bioscience, biotechnology, and biochemistry 16 18603769
2022 Abundant and cosmopolitan lineage of cyanopodoviruses lacking a DNA polymerase gene. The ISME journal 15 36357781
2021 Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA. Cells 14 34943861
1995 Monoclonal anti-FLAG antibodies react with a new isoform of rat Mg2+ dependent protein phosphatase beta. Biochemical and biophysical research communications 14 7532404
2006 Identification and reverse genetic analysis of mitochondrial processing peptidase and the core protein of the cytochrome bc1 complex of Caenorhabditis elegans, a model parasitic nematode. Journal of biochemistry 13 16788047
2001 Substrate binding changes conformation of the alpha-, but not the beta-subunit of mitochondrial processing peptidase. Archives of biochemistry and biophysics 13 11368022
2001 Inhibitory effects of barbiturates on nicotinic acetylcholine receptors in rat central nervous system neurons. Anesthesiology 12 11379692
1999 Complementation between mitochondrial processing peptidase (MPP) subunits from different species. Archives of biochemistry and biophysics 11 10496979
1998 Cloning and characterization of the gene encoding beta subunit of mitochondrial processing peptidase from the basidiomycete Lentinula edodes. Gene 11 9461410
2024 Distinct clinical characteristics of bocavirus and Mycoplasma pneumoniae infection in children plastic bronchitis. Immunity, inflammation and disease 10 39150240
2021 Novel IBA57 mutations in two chinese patients and literature review of multiple mitochondrial dysfunction syndrome. Metabolic brain disease 9 34709542
2015 Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects. The Journal of physiology 9 26378885
2021 iTRAQ-based quantitative proteomics suggests mitophagy involvement after Rice black-streaked dwarf virus acquisition in insect vector small brown planthopper Laodelphax striatellus Fallén. Journal of proteomics 7 34216810
2009 Acute lymphoblastic leukemia-derived dendritic cells express tumor associated antigens: PNPT1, PMPCB, RHAMM, BSG and ERCC1. Neoplasma 7 19580345
1996 Thermodynamics and kinetics of t-butylbicyclophosphorothionate binding differentiate convulsant and depressant barbiturate stereoisomers acting via GABAA ionophores. Naunyn-Schmiedeberg's archives of pharmacology 7 8692286
1998 Isolation, characterization, and expression of the gene encoding the beta subunit of the mitochondrial processing peptidase from Blastocladiella emersonii. Journal of bacteriology 6 9683495
1996 Catalytic mechanism of mitochondrial processing peptidase: fluorescence studies. Archives of biochemistry and biophysics 6 8806741
1999 Characterization and submitochondrial localization of the alpha subunit of the mitochondrial processing peptidase from the aquatic fungus Blastocladiella emersonii. Journal of bacteriology 5 10400583
2024 Integration of multi-omics technologies for molecular diagnosis in ataxia patients. Frontiers in genetics 4 38239855
2024 Leigh syndrome with developmental regression and ataxia due to a novel splicing variant in the PMPCB gene. Journal of human genetics 3 38374165
2022 DIA mass spectrometry characterizes urinary proteomics in neonatal and adult donkeys. Scientific reports 3 36585464
2022 Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growth. Frontiers in oncology 2 36313646
1994 Inter-individual differences of 4-[4-(4-methylphenyl)-phenylmethoxy-1-piperidinyl]butyric acid disposition in rats: possible involvement of genetic polymorphism. Drug metabolism and disposition: the biological fate of chemicals 2 7835229
2026 Inflammation Cascade-Directed Therapy by Biomimetic Polydopamine Nanosystem for Long-Term Management of Ischemic Stroke. Theranostics 1 41328343
2025 Transcriptome Analysis Revealed the Molecular Mechanism of Acetic Acid Increasing Monascus Pigment Production in Monascus ruber CICC41233. Journal of fungi (Basel, Switzerland) 1 39852468
2017 Enantiomeric barbiturates bind distinct inter- and intrasubunit binding sites in a nicotinic acetylcholine receptor (nAChR). The Journal of biological chemistry 1 28878016
2004 Opposite effects of depressant and convulsant barbiturate stereoisomers on acetylcholine release from the rat hippocampus in vivo. British journal of anaesthesia 1 14742336
1996 Evidences for adenine nucleotide binding in the subunits of Neurospora mitochondrial processing peptidase. Archives of biochemistry and biophysics 1 8806742
2026 Pmpcb modulates zebrafish neurogenesis and stress resistance via regulating mitochondria metabolism and function. Molecular neurobiology 0 41999531
2025 Identification of diagnostic biomarkers and mitochondrial metabolic characteristics in sepsis-associated acute kidney injury. European journal of medical research 0 41107920

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