Affinage

PLOD1

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 · UniProt Q02809

Length
727 aa
Mass
83.5 kDa
Annotated
2026-04-28
100 papers in source corpus 15 papers cited in narrative 15 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PLOD1 (lysyl hydroxylase 1) is an ER-resident α2 homodimeric enzyme that hydroxylates lysine residues in collagen and non-collagen substrates, thereby governing collagen crosslinking, extracellular matrix integrity, and additional signaling and structural functions in diverse cell types. The 709-amino-acid enzyme catalyzes the Fe²⁺- and 2-oxoglutarate-dependent hydroxylation of peptidyl lysine (EC 1.14.11.4) and also processes UDP-glycan donors via a distinct N-terminal glycosyltransferase domain (PMID:1577494, PMID:34400365). Loss-of-function mutations—frequently arising from Alu-mediated recombination at introns 9 and 16—cause Ehlers–Danlos syndrome type VI (kyphoscoliotic type), and PLOD1 deficiency in mice promotes aortic aneurysm through thrombospondin-1 upregulation and MMP activation (PMID:7713497, PMID:10874315, PMID:34646388). Beyond collagen, PLOD1 hydroxylates EBNA1 at K460/K461 to regulate its stability and oriP-dependent DNA replication, and binds Septin2 through its hydroxylase domain to promote actin polymerization and cancer cell confined migration (PMID:37262099, PMID:36721170).

Mechanistic history

Synthesis pass · year-by-year structured walk · 6 steps
  1. 1992 High

    Cloning of human PLOD1 established it as a 709-residue α2 homodimeric lysyl hydroxylase with a highly conserved C-terminal domain, defining the founding member of the PLOD enzyme family.

    Evidence cDNA cloning with cross-species sequence comparison and chromosomal mapping

    PMID:1577494

    Open questions at the time
    • No crystal structure of PLOD1 itself was obtained
    • Substrate specificity beyond collagen not addressed
    • Catalytic residues not mapped
  2. 1994 High

    Determination of the 19-exon gene structure revealed Alu-rich recombination hotspots in introns 9 and 16, explaining the molecular basis of the recurrent duplication mutation in Ehlers–Danlos syndrome type VI.

    Evidence Genomic clone isolation, intron sequencing, and Southern blot analysis of patient DNA

    PMID:7713497

    Open questions at the time
    • Mechanism by which Alu-mediated recombination is triggered remains undefined
    • Genotype-phenotype correlations across different mutation types not systematically established
  3. 2000 High

    Cataloguing multiple loss-of-function alleles (frameshift, nonsense, duplication) with <25% residual enzymatic activity confirmed that PLOD1 is the causal gene for EDS type VI and defined the activity threshold for clinical disease.

    Evidence cDNA/genomic sequencing and fibroblast enzymatic activity assays in multiple patients

    PMID:10874315

    Open questions at the time
    • Minimal residual activity sufficient for normal function not precisely defined
    • Contribution of PLOD2/PLOD3 compensation not assessed
  4. 2020 Medium

    Two studies expanded PLOD1's functional scope beyond connective tissue: lnc-URIDS was shown to bind PLOD1 protein and reduce its stability (impairing wound healing in diabetic skin), while PLOD1 was found to inactivate the Hippo-YAP pathway in osteosarcoma by suppressing LATS1/YAP phosphorylation.

    Evidence RNA-protein interaction and wound healing assays (diabetic model); gain/loss-of-function, luciferase 3′-UTR reporter, immunofluorescence, and in vivo tumorigenicity (osteosarcoma model)

    PMID:32446383 PMID:32801140

    Open questions at the time
    • Mechanism by which PLOD1 suppresses LATS1 phosphorylation is unknown
    • Whether lnc-URIDS regulation is specific to diabetic contexts is untested
    • Direct versus indirect effects on YAP signaling not distinguished
  5. 2021 High

    A cluster of studies revealed PLOD1's roles in vascular biology and cancer signaling: PLOD1 deficiency promoted aortic aneurysm via thrombospondin-1/MMP activation (rescued by AAV-LH1); PLOD1 was shown to possess glucosyltransferase activity through its N-terminal domain; and PLOD1 was linked to NF-κB signaling in glioma and SOX9/PI3K/Akt/mTOR activation in gastric cancer.

    Evidence LH1-deficient mouse with AAV rescue and MMP assays; in vitro UDP-glycan assays with domain mutagenesis; knockdown/overexpression in patient-derived glioma stem cells and gastric cancer lines with xenograft validation and epistatic rescue

    PMID:33420370 PMID:34400365 PMID:34455762 PMID:34646388

    Open questions at the time
    • Glucosyltransferase activity not confirmed in a cellular context
    • Whether NF-κB and PI3K/Akt effects are hydroxylase-dependent or scaffolding-based is unresolved
    • Thrombospondin-1 upregulation mechanism downstream of PLOD1 loss is indirect
  6. 2023 High

    PLOD1 was shown to hydroxylate the non-collagen substrate EBNA1 at K460/K461, controlling EBNA1 protein stability and oriP-dependent DNA replication, and separately to bind Septin2 via its hydroxylase domain, stabilizing Septin2 to promote actin polymerization and confined cancer cell migration.

    Evidence Mass spectrometry identification of EBNA1 hydroxylation sites with mutagenesis and episome maintenance assays; reciprocal Co-IP/LC-MS, FRET, FRAP, 3D invasion, and microfluidic confined migration with orthotopic mouse model for SEPT2 interaction

    PMID:36721170 PMID:37262099

    Open questions at the time
    • Whether PLOD1 hydroxylates Septin2 or acts solely as a binding partner is untested
    • Scope of non-collagen substrates beyond EBNA1 is undefined
    • Structural basis of PLOD1-SEPT2 interaction not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the full non-collagen substrate repertoire, the structural basis for PLOD1's dual hydroxylase/glycosyltransferase activities, and whether PLOD1's oncogenic signaling effects (NF-κB, Hippo-YAP, PI3K/Akt) depend on its enzymatic activity or on scaffolding interactions.
  • No crystal structure of human PLOD1 exists
  • Enzymatic versus scaffolding contributions to cancer phenotypes not dissected
  • Comprehensive identification of non-collagen substrates not performed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016491 oxidoreductase activity 4 GO:0016740 transferase activity 1
Localization
GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-1474244 Extracellular matrix organization 4 R-HSA-392499 Metabolism of proteins 3 R-HSA-1643685 Disease 2 GO:0005783 endoplasmic reticulum 1
Partners
EBNA1SEPT2THBS1

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 Human PLOD1 (lysyl hydroxylase 1) encodes a 709 amino acid α2 dimer enzyme (EC 1.14.11.4) that catalyzes hydroxylation of lysine residues in peptide linkages to form hydroxylysine in collagens; the C-terminal region (especially residues 639-715) is highly conserved (99% identity with chick) and likely contains functionally significant sequences. cDNA cloning, amino acid sequence analysis, cross-species sequence comparison, chromosomal mapping by somatic cell hybrids and in situ hybridization Genomics High 1577494
1994 The PLOD1 gene contains 19 exons; introns 9 and 16 contain extensive Alu sequences that generate recombination hotspots, explaining the common large duplication mutations found in Ehlers-Danlos syndrome type VI patients. The gene's constitutive expression across tissues suggests an essential housekeeping function. Genomic clone isolation, intron sequencing, Southern blot analysis of patient DNA Genomics High 7713497
2000 Loss-of-function mutations in PLOD1 (including frameshift 1702insC, nonsense mutations Y142X, Q327X, R670X, Y511X, and a seven-exon duplication) result in lysyl hydroxylase activity <25% of normal, causing Ehlers-Danlos syndrome type VI characterized by kyphoscoliosis and skin/joint extensibility. cDNA and genomic DNA sequencing, enzymatic activity assay in dermal fibroblasts, prenatal mutation analysis Human mutation High 10874315
2020 lnc-URIDS (lncRNA) binds directly to PLOD1 protein, decreasing its protein stability, which leads to dysregulation of collagen production and deposition and delayed wound healing in diabetic skin. RNA-protein interaction assay, lncRNA knockdown in vitro and in vivo, wound healing assay, protein stability measurement Diabetes Medium 32801140
2021 PLOD1 (LH1) deficiency in mice promotes angiotensin II-induced dissecting abdominal aortic aneurysm by upregulating thrombospondin-1, which in turn enables proinflammatory processes, matrix metalloproteinase (MMP) activation, and vascular smooth muscle cell apoptosis; AAV-mediated restoration of LH1 normalized thrombospondin-1 and alleviated AAA. LH1-deficient mouse model, Ang II infusion, whole-transcriptomic analysis, AAV rescue experiment, TAX2 thrombospondin-1 inhibitor treatment, MMP activity assay Theranostics High 34646388
2021 Wild-type PLOD1 is capable of processing UDP-glycan donor substrates (glucosyltransferase activity), identifying a previously unrecognized glycosyltransferase function; a pathogenic missense variant p.(Ser178Arg) affects folding stability of the N-terminal glycosyltransferase domain and attenuates this activity. In VSMCs, PLOD1 overexpression upregulates procollagen gene expression (secretory function), while PLOD1 knockdown causes hypercontractility and upregulation of contractile markers. In vitro UDP-glycan substrate assay, domain stability analysis, VSMC overexpression/knockdown, procollagen gene expression analysis, collagen fibril morphometry Translational research : the journal of laboratory and clinical medicine Medium 34400365
2023 PLOD1 promotes confined migration and metastasis of cancer cells by binding and stabilizing Septin2 (SEPT2), thereby enhancing actin polymerization; this interaction depends on the hydroxylase domain of LH1. LH1 was identified as interacting with SEPT2 by immunoprecipitation/LC-MS. LC-MS proteomics, immunoprecipitation, FRET, FRAP, 3D invasion assay, confined migration microfluidic device, orthotopic mouse model, in vivo imaging Molecular cancer Medium 36721170
2023 PLOD1 interacts with EBNA1 (Epstein-Barr virus nuclear antigen 1) and hydroxylates EBNA1 at lysine K460 (and K461), regulating EBNA1 protein stability and oriP-dependent DNA replication; mutation of K460 abrogates EBNA1-driven DNA replication, while mutations in both K460/K461 reduce EBNA1 protein stability and perturb PLOD1 interaction. Proteomic analysis of EBNA1 interactors, shRNA depletion of PLOD1, small molecule inhibition (2,2'-dipyridyl), mass spectrometry identification of lysine hydroxylation sites, site-directed mutagenesis, oriP DNA replication assay, episome maintenance assay PLoS pathogens High 37262099
2021 PLOD1 promotes GBM malignant phenotype (viability, proliferation, migration, mesenchymal transition) via the NF-κB signaling pathway; hypoxic environments enhance these tumor-promoting effects of PLOD1. PLOD1 knockdown/overexpression in patient-derived glioma stem cells, tumor xenograft, bioinformatics pathway analysis, in vitro functional assays Oncogene Medium 33420370
2021 PLOD1 promotes cell growth and aerobic glycolysis in gastric cancer by activating the SOX9/PI3K/Akt/mTOR signaling pathway; PLOD1 expression positively correlates with SOX9, HK2, and LDHA levels, and SOX9 overexpression rescues the inhibitory effects of PLOD1 knockdown. PLOD1 overexpression/knockdown, metabolic assays (glucose uptake, lactate, ATP, OCR, ECAR), Western blotting, in vivo tumor formation, rescue experiment with SOX9 Frontiers in bioscience (Landmark edition) Medium 34455762
2020 PLOD1 inactivates the Hippo-YAP pathway in osteosarcoma by inhibiting phosphorylation of LATS1 (p-LATS1) and YAP (p-YAP), leading to increased nuclear YAP distribution, and promotes proliferation, migration, invasion, and metastasis. miR-34c directly targets PLOD1 mRNA 3'-UTR to suppress PLOD1 expression. Gain/loss-of-function assays, luciferase reporter 3'-UTR assay, immunofluorescence for nuclear YAP, in vivo tumorigenicity/metastasis, Western blotting Biochemical and biophysical research communications Medium 32446383
2023 SIRT6 regulates ovarian follicular development partly through Plod1: SIRT6 knockout mice show decreased Plod1 mRNA and protein in ovaries and granulosa cells, associated with disrupted collagen crosslinking/deposition and ovarian hypoplasia. SIRT6 KO mouse model, RT-PCR, Western blotting, follicle counting, collagen staining in ovarian stroma Aging cell Low 37936548
2006 A coding polymorphism in PLOD1 exon 3 (G386A, resulting in A99T) is associated with reduced lumbar spine bone mineral density and a significantly increased hydroxylysylpyridinoline to lysylpyridinoline ratio, suggesting a functional effect on lysyl hydroxylase enzymatic activity in vivo. Population-based cohort genotyping, urinary crosslink ratio measurement Osteoporosis international Low 16758144
2019 SiMPLOD database integrates structural and mutation data for PLOD/LH enzymes; the available 3D structure of LH3/PLOD3 and a viral LH/PLOD homolog fragment enable molecular mapping of disease-causing mutations in PLOD1 and other family members, providing structural context for pathogenic variants. Structural bioinformatics, database curation using available crystal structures Journal of bone and mineral research Low 30721533
2021 PLOD1 promotes glioma cell proliferation and colony formation through activation of the HSF1 signaling pathway and subsequent survivin accumulation; luciferase reporter assays showed PLOD1 enhances HSF1 transcriptional activity, and HSF1 inhibitor (KRIBB11) abolished PLOD1-overexpression-induced clonogenic growth. PLOD1 overexpression/knockdown, luciferase reporter assay for HSF1 transcriptional activity, HSF1 pharmacologic inhibition (KRIBB11), CCK8/colony formation assays Molecular and cellular biochemistry Low 34845571

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Structure of the LH1-RC complex from Thermochromatium tepidum at 3.0 Å. Nature 149 24670637
1992 Mutants of Rhodobacter sphaeroides lacking one or more pigment-protein complexes and complementation with reaction-centre, LH1, and LH2 genes. Molecular microbiology 131 1588816
2018 Structure of photosynthetic LH1-RC supercomplex at 1.9 Å resolution. Nature 122 29618814
1992 Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3----p36.2. Genomics 120 1577494
2013 Three-dimensional structure of the Rhodobacter sphaeroides RC-LH1-PufX complex: dimerization and quinone channels promoted by PufX. Biochemistry 94 24131108
1999 The reaction center-LH1 antenna complex of Rhodobacter sphaeroides contains one PufX molecule which is involved in dimerization of this complex. Biochemistry 94 10346905
1998 The LH1-RC core complex of Rhodobacter sphaeroides: interaction between components, time-dependent assembly, and topology of the PufX protein. Biochimica et biophysica acta 60 9814844
2021 Structures of Rhodopseudomonas palustris RC-LH1 complexes with open or closed quinone channels. Science advances 56 33523887
2021 Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-κB signaling. Oncogene 51 33420370
2005 Mutation analysis of the PLOD1 gene: an efficient multistep approach to the molecular diagnosis of the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VIA). Molecular genetics and metabolism 51 15979919
1996 Consequences for the organization of reaction center-light harvesting antenna 1 (LH1) core complexes of Rhodobacter sphaeroides arising from deletion of amino acid residues from the C terminus of the LH1 alpha polypeptide. The Journal of biological chemistry 51 8621732
2012 Separation, purification, and α-glucosidase inhibition of polysaccharides from Coriolus versicolor LH1 mycelia. Carbohydrate polymers 49 23218298
2009 Structural model and excitonic properties of the dimeric RC-LH1-PufX complex from Rhodobacter sphaeroides. Chemical physics 48 20161332
2021 Cryo-EM structure of the monomeric Rhodobacter sphaeroides RC-LH1 core complex at 2.5 Å. The Biochemical journal 46 34590677
2020 Novel Long Noncoding RNA lnc-URIDS Delays Diabetic Wound Healing by Targeting Plod1. Diabetes 46 32801140
1994 Structure and expression of the human lysyl hydroxylase gene (PLOD): introns 9 and 16 contain Alu sequences at the sites of recombination in Ehlers-Danlos syndrome type VI patients. Genomics 46 7713497
2020 Cryo-EM structure of a Ca2+-bound photosynthetic LH1-RC complex containing multiple αβ-polypeptides. Nature communications 44 33009385
2001 Dynamics of excitation energy transfer in the LH1 and LH2 light-harvesting complexes of photosynthetic bacteria. Biochemistry 42 11735388
1995 Genetic and biochemical characterization of the Lactobacillus delbrueckii subsp. lactis bacteriophage LL-H lysin. Applied and environmental microbiology 41 8526515
2021 Cryo-EM Structure of the Photosynthetic LH1-RC Complex from Rhodospirillum rubrum. Biochemistry 39 34323477
2004 Carotenoid-induced cooperative formation of bacterial photosynthetic LH1 complex. Biochemistry 38 15610043
2018 Biodegradation of phenanthrene by biodemulsifier-producing strain Achromobacter sp. LH-1 and the study on its metabolisms and fermentation kinetics. Ecotoxicology and environmental safety 37 30055385
2011 Bioconversion of ginsenoside rb1 into compound k by Leuconostoc citreum LH1 isolated from kimchi. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 35 24031746
2021 Cryo-EM structure of the photosynthetic RC-LH1-PufX supercomplex at 2.8-Å resolution. Science advances 34 34134992
2021 Cryo-EM structure of the dimeric Rhodobacter sphaeroides RC-LH1 core complex at 2.9 Å: the structural basis for dimerisation. The Biochemical journal 34 34622934
2018 High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma. Genetic testing and molecular biomarkers 32 29723071
1995 A group I intron in the terminase gene of Lactobacillus delbrueckii subsp. lactis phage LL-H. Microbiology (Reading, England) 32 7496530
2024 LncRNA FOXD2-AS1 promotes the growth, invasion and migration of OSCC cells by regulating the MiR-185-5p/PLOD1/Akt/mTOR pathway. Cancer genetics 31 38729078
2023 Structural diversity and modularity of photosynthetic RC-LH1 complexes. Trends in microbiology 31 37380557
2022 Asymmetric structure of the native Rhodobacter sphaeroides dimeric LH1-RC complex. Nature communications 31 35393413
2021 A previously unrecognized membrane protein in the Rhodobacter sphaeroides LH1-RC photocomplex. Nature communications 31 34728609
2021 PLOD1 promotes cell growth and aerobic glycolysis by regulating the SOX9/PI3K/Akt/mTOR signaling pathway in gastric cancer. Frontiers in bioscience (Landmark edition) 30 34455762
2002 A conserved C-terminal region in Gp71 of the small isometric-head phage LL-H and ORF474 of the prolate-head phage JCL1032 is implicated in specificity of adsorption of phage to its host, Lactobacillus delbrueckii. Journal of bacteriology 30 11948159
1986 Physical and genetic characterization of the genome of Lactobacillus lactis bacteriophage LL-H. Journal of virology 29 3016319
2022 An LH1-RC photocomplex from an extremophilic phototroph provides insight into origins of two photosynthesis proteins. Communications biology 26 36344631
2015 The origin of the unusual Qy red shift in LH1-RC complexes from purple bacteria Thermochromatium tepidum as revealed by Stark absorption spectroscopy. Biochimica et biophysica acta 26 26341015
2011 Carotenoids are essential for normal levels of dimerisation of the RC-LH1-PufX core complex of Rhodobacter sphaeroides: characterisation of R-26 as a crtB (phytoene synthase) mutant. Biochimica et biophysica acta 26 21651888
2010 Energy Transfer Dynamics in an RC-LH1-PufX Tubular Photosynthetic Membrane. New journal of physics 26 21152381
2017 Association of ECRG4 with PLK1, CDK4, PLOD1 and PLOD2 in esophageal squamous cell carcinoma. American journal of translational research 25 28861165
2013 Structural studies of the cell wall polysaccharides from three strains of Lactobacillus helveticus with different autolytic properties: DPC4571, BROI, and LH1. Carbohydrate research 25 23831635
2013 The extracellular phage-host interactions involved in the bacteriophage LL-H infection of Lactobacillus delbrueckii ssp. lactis ATCC 15808. Frontiers in microbiology 25 24400001
2011 Cross-species investigation of the functions of the Rhodobacter PufX polypeptide and the composition of the RC-LH1 core complex. Biochimica et biophysica acta 25 22079525
1994 Characterization of the genome region encoding structural proteins of Lactobacillus delbrueckii subsp. lactis bacteriophage LL-H. Gene 25 7828907
2021 Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)-induced dissecting abdominal aortic aneurysm. Theranostics 24 34646388
2011 Monomeric RC-LH1 core complexes retard LH2 assembly and intracytoplasmic membrane formation in PufX-minus mutants of Rhodobacter sphaeroides. Biochimica et biophysica acta 24 21663730
2006 Hexacoordination of bacteriochlorophyll in photosynthetic antenna LH1. Biochemistry 24 16460037
2021 Crystal structure of a photosynthetic LH1-RC in complex with its electron donor HiPIP. Nature communications 22 33597527
2012 Potential antidiabetic activity of extracellular polysaccharides in submerged fermentation culture of Coriolus versicolor LH1. Carbohydrate polymers 22 24751027
2023 Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network. Molecular cancer 21 36721170
1996 Defective site-specific integration elements are present in the genome of virulent bacteriophage LL-H of Lactobacillus delbrueckii. Applied and environmental microbiology 21 8633887
1996 The early gene region completes the nucleotide sequence of Lactobacillus delbrueckii subsp. lactis phage LL-H. Gene 21 8917075
2023 Rhodobacter capsulatus forms a compact crescent-shaped LH1-RC photocomplex. Nature communications 20 36792596
2008 Partial site-specific assignment of a uniformly (13)C, (15)N enriched membrane protein, light-harvesting complex 1 (LH1), by solid state NMR. Biochimica et biophysica acta 20 18267103
2005 Characterization of a highly purified, fully active, crystallizable RC-LH1-PufX core complex from Rhodobacter sphaeroides. Photosynthesis research 20 16172926
2021 New mechanistic insights to PLOD1-mediated human vascular disease. Translational research : the journal of laboratory and clinical medicine 19 34400365
2019 SiMPLOD, a Structure-Integrated Database of Collagen Lysyl Hydroxylase (LH/PLOD) Enzyme Variants. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19 30721533
2003 A reaction center-light-harvesting 1 complex (RC-LH1) from a Rhodospirillum rubrum mutant with altered esterifying pigments: characterization by optical spectroscopy and cryo-electron microscopy. The Journal of biological chemistry 19 12719425
2010 Dimerisation of the Rhodobacter sphaeroides RC-LH1 photosynthetic complex is not facilitated by a GxxxG motif in the PufX polypeptide. Biochimica et biophysica acta 18 20646993
2020 Distribution of the Warmblood Fragile Foal Syndrome Type 1 Mutation (PLOD1 c.2032G>A) in Different Horse Breeds from Europe and the United States. Genes 17 33353040
2014 Aberrant assembly complexes of the reaction center light-harvesting 1 PufX (RC-LH1-PufX) core complex of Rhodobacter sphaeroides imaged by atomic force microscopy. The Journal of biological chemistry 17 25193660
1994 Probing the structure of the core light-harvesting complex (LH1) of Rhodopseudomonas viridis by dissociation and reconstitution methodology. Photosynthesis research 17 24309943
2020 PLOD1, a target of miR-34c, contributes to cell growth and metastasis via repressing LATS1 phosphorylation and inactivating Hippo pathway in osteosarcoma. Biochemical and biophysical research communications 16 32446383
2019 Transcriptome Profiling of Primary Skin Fibroblasts Reveal Distinct Molecular Features Between PLOD1- and FKBP14-Kyphoscoliotic Ehlers-Danlos Syndrome. Genes 16 31288483
2019 Warmblood fragile foal syndrome type 1 mutation (PLOD1 c.2032G>A) is not associated with catastrophic breakdown and has a low allele frequency in the Thoroughbred breed. Equine veterinary journal 15 31502696
2014 A case of Ehlers-Danlos syndrome type VIA with a novel PLOD1 gene mutation. Pediatric neurology 15 25266621
2006 Association of PLOD1 polymorphisms with bone mineral density in a population-based study of women from the UK. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 15 16758144
2017 Engineering of a calcium-ion binding site into the RC-LH1-PufX complex of Rhodobacter sphaeroides to enable ion-dependent spectral red-shifting. Biochimica et biophysica acta. Bioenergetics 14 28826909
2013 Single-molecule spectroscopy on RC-LH1 complexes of Rhodopseudomonas acidophila strain 10050. The journal of physical chemistry. B 14 23445346
2001 Time-dependent changes in the carotenoid composition and preferential binding of spirilloxanthin to the reaction center and anhydrorhodovibrin to the LH1 antenna complex in Rhodobium marinum. Photochemistry and photobiology 14 11594059
2000 Mutational analysis of the lysyl hydroxylase 1 gene (PLOD) in six unrelated patients with Ehlers-Danlos syndrome type VI: prenatal exclusion of this disorder in one family. Human mutation 14 10874315
2016 Spectroscopic and Thermodynamic Characterization of the Metal-Binding Sites in the LH1-RC Complex from Thermophilic Photosynthetic Bacterium Thermochromatium tepidum. The journal of physical chemistry. B 13 27973820
2012 Ca(2+)-binding reduces conformational flexibility of RC-LH1 core complex from thermophile Thermochromatium tepidum. Photosynthesis research 13 22367594
2012 Structure of the dimeric RC-LH1-PufX complex from Rhodobaca bogoriensis investigated by electron microscopy. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 13 23148268
2020 Hanoverian F/W-line contributes to segregation of Warmblood fragile foal syndrome type 1 variant PLOD1:c.2032G>A in Warmblood horses. Equine veterinary journal 12 32323341
2006 Effective plasmid pX3 transduction in Lactobacillus delbrueckii by bacteriophage LL-H. Plasmid 12 16458963
2003 Interaction of bacteriochlorophyll with the LH1 and PufX polypeptides of photosynthetic bacteria: use of chemically synthesized analogs and covalently attached fluorescent probes. Photosynthesis research 12 16228601
1992 Purification and crystallization of the light harvesting LH1 complex from Rhodobacter sphaeroides. Journal of molecular biology 12 1474590
2023 Regulation of EBNA1 protein stability and DNA replication activity by PLOD1 lysine hydroxylase. PLoS pathogens 11 37262099
2023 Identification of Regulatory Molecular "Hot Spots" for LH/PLOD Collagen Glycosyltransferase Activity. International journal of molecular sciences 11 37446392
2020 LH1-RC light-harvesting photocycle under realistic light-matter conditions. The Journal of chemical physics 10 32321270
2007 Probing binding site of bacteriochlorophyll a and carotenoid in the reconstituted LH1 complex from Rhodospirillum rubrum S1 by Stark spectroscopy. Photosynthesis research 10 17912603
2000 Exchanging cofactors in the core antennae from purple bacteria: structure and properties of Zn-bacteriopheophytin-containing LH1. Biochemistry 10 10653655
1994 Biochemical and spectroscopic characterization of the reaction center-LH1 complex and the carotenoid-containing B820 subunit of Chromatium purpuratum. Biochimica et biophysica acta 10 8167136
1987 Transmembrane cation movements during infection of Lactobacillus lactis by bacteriophage LL-H. The Journal of general virology 10 3585280
2022 First reported case of fragile foal syndrome type 1 in the Thoroughbred caused by PLOD1 c.2032G>A. Equine veterinary journal 9 34939209
2021 PLOD1 acts as a tumor promoter in glioma via activation of the HSF1 signaling pathway. Molecular and cellular biochemistry 9 34845571
2013 Influence of hydrophobic micelle structure on crystallization of the photosynthetic RC-LH1-PufX complex from Rhodobacter blasticus. The journal of physical chemistry. B 9 23806126
2011 A DNA pooling-based case-control study of myopia candidate genes COL11A1, COL18A1, FBN1, and PLOD1 in a Chinese population. Molecular vision 9 21527992
2006 The photosynthetic deficiency due to puhC gene deletion in Rhodobacter capsulatus suggests a PuhC protein-dependent process of RC/LH1/PufX complex reorganization. Archives of biochemistry and biophysics 9 16949540
2023 SIRT6 deficiency causes ovarian hypoplasia by affecting Plod1-related collagen formation. Aging cell 8 37936548
2020 The first case report of Kyphoscoliotic Ehlers-Danlos syndrome of chinese origin with a novel PLOD1 gene mutation. BMC medical genetics 8 33129265
2021 Posttranscriptional control of PLOD1 in adipose-derived stem cells regulates scar formation through altering macrophage polarization. Annals of translational medicine 7 34790779
1982 Factors affecting in vitro DNA ejection of the Lactobacillus lactis bacteriophage LL-H. The Journal of general virology 7 7069401
2025 A Native LH1-RC-HiPIP Supercomplex from an Extremophilic Phototroph. Communications biology 6 39799244
2024 Insights into the divergence of the photosynthetic LH1 complex obtained from structural analysis of the unusual photocomplexes of Roseospirillum parvum. Communications biology 6 39702771
2020 Mechanism of the biodemulsifier-enhanced biodegradation of phenanthrene by Achromobacter sp. LH-1. Colloids and surfaces. B, Biointerfaces 6 32673989
2012 Genetic analysis and fine mapping of LH1 and LH2, a set of complementary genes controlling late heading in rice (Oryza sativa L.). Breeding science 6 23341744
2023 Hysteretic Pressure Dependence of Ca2+ Binding in LH1 Bacterial Membrane Chromoproteins. The journal of physical chemistry. B 5 36608327
2018 Novel features of LH1-RC from Thermochromatium tepidum revealed from its atomic resolution structure. The FEBS journal 5 30328658
2007 [Purification and properties of an antimicrobial substance from marine Brevibacillus laterosporus Lh-1]. Wei sheng wu xue bao = Acta microbiologica Sinica 5 18271253