- Length
- 437 aa
- Mass
- 48.1 kDa
- Annotated
- 2026-06-14
100 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 100 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2002 | Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. | The Journal of biological chemistry | 325 | 12077142 |
| 2002 | ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts. | American journal of physiology. Endocrinology and metabolism | 236 | 12217895 |
| 2016 | AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA. | Autophagy | 222 | 26902588 |
| 2017 | The constitutive lipid droplet protein PLIN2 regulates autophagy in liver. | Autophagy | 206 | 28548876 |
| 1999 | Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. | The Journal of biological chemistry | 189 | 10358026 |
| 1989 | Autosomal dominant retinitis pigmentosa (ADRP): localization of an ADRP gene to the long arm of chromosome 3. | Genomics | 176 | 2613244 |
| 2005 | Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet. | Biochemical and biophysical research communications | 145 | 16403437 |
| 2003 | Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism. | Mechanisms of development | 123 | 14550535 |
| 2005 | ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells. | Journal of lipid research | 119 | 16230742 |
| 2008 | Inhibition of ADRP prevents diet-induced insulin resistance. | American journal of physiology. Gastrointestinal and liver physiology | 100 | 18669627 |
| 2006 | Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line. | The Journal of biological chemistry | 100 | 16968708 |
| 2000 | Stimulation of adipose differentiation related protein (ADRP) expression in adipocyte precursors by long-chain fatty acids. | Journal of cellular physiology | 92 | 10623894 |
| 2016 | Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha. | Stem cells and development | 84 | 27308945 |
| 2010 | Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP). | Journal of cellular physiology | 77 | 20143336 |
| 2018 | N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2. | The Journal of biological chemistry | 76 | 30425097 |
| 2005 | Molecular genetics of autosomal dominant retinitis pigmentosa (ADRP): a comprehensive study of 43 Italian families. | Journal of medical genetics | 72 | 15994872 |
| 2015 | PPARG modulated lipid accumulation in dairy GMEC via regulation of ADRP gene. | Journal of cellular biochemistry | 70 | 25169669 |
| 2013 | Increased Plin2 expression in human skeletal muscle is associated with sarcopenia and muscle weakness. | PloS one | 67 | 23977392 |
| 2011 | Identification of disease-causing mutations in autosomal dominant retinitis pigmentosa (adRP) using next-generation DNA sequencing. | Investigative ophthalmology & visual science | 65 | 20861475 |
| 2012 | Direct interaction of Plin2 with lipids on the surface of lipid droplets: a live cell FRET analysis. | American journal of physiology. Cell physiology | 64 | 22744009 |
| 2023 | Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation. | Developmental cell | 61 | 37494933 |
| 2017 | PLIN2 is a Key Regulator of the Unfolded Protein Response and Endoplasmic Reticulum Stress Resolution in Pancreatic β Cells. | Scientific reports | 61 | 28102311 |
| 2022 | Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. | Cell death and differentiation | 59 | 35614132 |
| 2006 | A large deletion in the adRP gene PRPF31: evidence that haploinsufficiency is the cause of disease. | Molecular vision | 59 | 16636657 |
| 2019 | Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart. | Scientific reports | 56 | 31061399 |
| 2018 | PLIN2 Is Essential for Trophoblastic Lipid Droplet Accumulation and Cell Survival During Hypoxia. | Endocrinology | 55 | 30351430 |
| 2008 | Expression of adipose differentiation-related protein (ADRP) and perilipin in macrophages infected with Mycobacterium leprae. | FEMS microbiology letters | 53 | 19054096 |
| 2017 | Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress, Plin2 degradation, and cell death in H9C2 cardiomyoblasts. | Experimental cell research | 51 | 28336294 |
| 2013 | PLIN2, the major perilipin regulated during sebocyte differentiation, controls sebaceous lipid accumulation in vitro and sebaceous gland size in vivo. | Biochimica et biophysica acta | 50 | 23688400 |
| 2021 | SARS-CoV-2 exploits host DGAT and ADRP for efficient replication. | Cell discovery | 48 | 34702802 |
| 2008 | Crystal structures of two coronavirus ADP-ribose-1''-monophosphatases and their complexes with ADP-Ribose: a systematic structural analysis of the viral ADRP domain. | Journal of virology | 48 | 18987156 |
| 2013 | The minor allele of the missense polymorphism Ser251Pro in perilipin 2 (PLIN2) disrupts an α-helix, affects lipolysis, and is associated with reduced plasma triglyceride concentration in humans. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 46 | 23603836 |
| 2021 | Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics. | Biochimica et biophysica acta. Molecular and cell biology of lipids | 43 | 33713834 |
| 2006 | Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. | Journal of lipid research | 42 | 16391323 |
| 2006 | Analysis of interaction partners for perilipin and ADRP on lipid droplets. | Molecular and cellular biochemistry | 40 | 16532261 |
| 2000 | RP1 protein truncating mutations predominate at the RP1 adRP locus. | Investigative ophthalmology & visual science | 40 | 11095597 |
| 2015 | PLIN2 inhibits insulin-induced glucose uptake in myoblasts through the activation of the NLRP3 inflammasome. | International journal of molecular medicine | 38 | 26166692 |
| 2009 | ADRP/ADFP and Mal1 expression are increased in macrophages treated with TLR agonists. | Atherosclerosis | 38 | 19748622 |
| 2006 | Regulation of Triglyceride Metabolism. III. Emerging role of lipid droplet protein ADFP in health and disease. | American journal of physiology. Gastrointestinal and liver physiology | 38 | 17194897 |
| 2004 | ADRP is dissociated from lipid droplets by ARF1-dependent mechanism. | Biochemical and biophysical research communications | 37 | 15336557 |
| 2017 | Induction of neuroendocrine differentiation in castration resistant prostate cancer cells by adipocyte differentiation-related protein (ADRP) delivered by exosomes. | Cancer letters | 36 | 28109910 |
| 2015 | Genotype and Phenotype Studies in Autosomal Dominant Retinitis Pigmentosa (adRP) of the French Canadian Founder Population. | Investigative ophthalmology & visual science | 36 | 26720483 |
| 2014 | Activation of farnesoid X receptor (FXR) protects against fructose-induced liver steatosis via inflammatory inhibition and ADRP reduction. | Biochemical and biophysical research communications | 36 | 24875360 |
| 2014 | Gene augmentation for adRP mutations in RHO. | Cold Spring Harbor perspectives in medicine | 36 | 25037104 |
| 2021 | Integrated Action of Autophagy and Adipose Tissue Triglyceride Lipase Ameliorates Diet-Induced Hepatic Steatosis in Liver-Specific PLIN2 Knockout Mice. | Cells | 34 | 33923083 |
| 2009 | Oleic acid-induced ADRP expression requires both AP-1 and PPAR response elements, and is reduced by Pycnogenol through mRNA degradation in NMuLi liver cells. | American journal of physiology. Endocrinology and metabolism | 34 | 19383873 |
| 2017 | HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. | Developmental cell | 32 | 28966044 |
| 2013 | Expression of PLIN2 and PLIN3 during oocyte maturation and early embryo development in cattle. | Theriogenology | 32 | 24210669 |
| 2010 | Intracellular lipid droplets contain dynamic pools of sphingomyelin: ADRP binds phospholipids with high affinity. | Lipids | 32 | 20473576 |
| 2020 | UVA Induced Oxidative Stress Was Inhibited by Paeoniflorin/Nrf2 Signaling or PLIN2. | Frontiers in pharmacology | 31 | 32499710 |
| 2019 | Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets. | Molecular nutrition & food research | 30 | 31325205 |
| 2013 | Plin2 inhibits cellular glucose uptake through interactions with SNAP23, a SNARE complex protein. | PloS one | 30 | 24040030 |
| 2024 | Exercise ameliorates lipid droplet metabolism disorder by the PLIN2-LIPA axis-mediated lipophagy in mouse model of non-alcoholic fatty liver disease. | Biochimica et biophysica acta. Molecular basis of disease | 29 | 38306800 |
| 2021 | Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex. | Journal of lipid research | 29 | 33582145 |
| 2014 | Application of next-generation sequencing to identify genes and mutations causing autosomal dominant retinitis pigmentosa (adRP). | Advances in experimental medicine and biology | 29 | 24664689 |
| 2022 | Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death. | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | 28 | 36031387 |
| 2011 | Subcellular localization of skeletal muscle lipid droplets and PLIN family proteins OXPAT and ADRP at rest and following contraction in rat soleus muscle. | American journal of physiology. Regulatory, integrative and comparative physiology | 28 | 22012700 |
| 1992 | Point mutations of rhodopsin gene found in Japanese families with autosomal dominant retinitis pigmentosa (ADRP). | The Japanese journal of human genetics | 27 | 1391967 |
| 2005 | Expression of adipose differentiation-related protein (ADRP) is conjointly regulated by PU.1 and AP-1 in macrophages. | Journal of biochemistry | 26 | 16272134 |
| 1998 | Stimulation of adipose differentiation related protein (ADRP) expression by ibuprofen and indomethacin in adipocyte precursors and in adipocytes. | The Biochemical journal | 26 | 9480894 |
| 1993 | Structure of the gene encoding mouse adipose differentiation-related protein (ADRP). | Genomics | 26 | 8325636 |
| 2019 | Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed-forward loop between LXR and autophagy. | Journal of internal medicine | 24 | 31251843 |
| 2012 | Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages. | PloS one | 24 | 22427949 |
| 2012 | Transient scrotal hyperthermia induces lipid droplet accumulation and reveals a different ADFP expression pattern between the testes and liver in mice. | PloS one | 24 | 23056214 |
| 2010 | New SNP of the porcine perilipin 2 (PLIN2) gene, association with carcass traits and expression analysis in skeletal muscle. | Molecular biology reports | 24 | 20842447 |
| 2025 | PLIN2 Promotes Lipid Accumulation in Ascites-Associated Macrophages and Ovarian Cancer Progression by HIF1α/SPP1 Signaling. | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | 23 | 39921309 |
| 2016 | Study on quantitative expression of PPARγ and ADRP in muscle and its association with intramuscular fat deposition of pig. | SpringerPlus | 21 | 27652074 |
| 2002 | [Genetic and molecular characterization of 148 patients with autosomal dominant retinitis pigmentosa (ADRP)]. | Archivos de la Sociedad Espanola de Oftalmologia | 21 | 12221539 |
| 2024 | TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2. | Cell death & disease | 20 | 38561354 |
| 2023 | Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice. | Journal of lipid research | 20 | 37844775 |
| 2022 | PLIN2 promotes HCC cells proliferation by inhibiting the degradation of HIF1α. | Experimental cell research | 19 | 35697078 |
| 2006 | A study of the nuclear trafficking of the splicing factor protein PRPF31 linked to autosomal dominant retinitis pigmentosa (ADRP). | Biochimica et biophysica acta | 19 | 16427773 |
| 2024 | Therapeutic siRNA targeting PLIN2 ameliorates steatosis, inflammation, and fibrosis in steatotic liver disease models. | Journal of lipid research | 18 | 39187042 |
| 2017 | CEBPA-mediated upregulation of the lncRNA PLIN2 promotes the development of chronic myelogenous leukemia via the GSK3 and Wnt/β-catenin signaling pathways. | American journal of cancer research | 18 | 28560057 |
| 2015 | The perilipin 2 (PLIN2) gene Ser251Pro missense mutation is associated with reduced insulin secretion and increased insulin sensitivity in Italian obese subjects. | Diabetes/metabolism research and reviews | 18 | 26443937 |
| 2018 | The Expression Pattern of PLIN2 in Differentiated Adipocytes from Qinchuan Cattle Analysis of Its Protein Structure and Interaction with CGI-58. | International journal of molecular sciences | 17 | 29723991 |
| 2018 | Long-chain metabolites of vitamin E: Interference with lipotoxicity via lipid droplet associated protein PLIN2. | Biochimica et biophysica acta. Molecular and cell biology of lipids | 17 | 29733984 |
| 2020 | Lipid droplets are both highly oxidized and Plin2-covered in hepatocytes of diet-induced obese mice. | Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme | 16 | 32585124 |
| 2020 | ADFP promotes cell proliferation in lung adenocarcinoma via Akt phosphorylation. | Journal of cellular and molecular medicine | 16 | 33249703 |
| 2018 | The ADRP domain from a virulent strain of infectious bronchitis virus is not sufficient to confer a pathogenic phenotype to the attenuated Beaudette strain. | The Journal of general virology | 16 | 29893665 |
| 2018 | A novel mutation in the PRPF31 in a North Indian adRP family with incomplete penetrance. | Documenta ophthalmologica. Advances in ophthalmology | 16 | 30099644 |
| 2015 | Natural Functions of PLIN2 Mediating Wnt/LiCl Signaling and Glycogen Synthase Kinase 3 (GSK3)/GSK3 Substrate-Related Effects Are Modulated by Lipid. | Molecular and cellular biology | 16 | 26598603 |
| 2014 | Expression of perilipin 2 (PLIN2) in porcine oocytes during maturation. | Reproduction in domestic animals = Zuchthygiene | 16 | 25131988 |
| 1992 | Autosomal dominant retinitis pigmentosa (adRP; RP6): cosegregation of RP6 and the peripherin-RDS locus in a late-onset family of Irish origin. | American journal of human genetics | 15 | 1539599 |
| 2023 | Nuclear miR-150 enhances hepatic lipid accumulation by targeting RNA transcripts overlapping the PLIN2 promoter. | iScience | 14 | 37736048 |
| 2022 | An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase. | EMBO reports | 14 | 35132760 |
| 2014 | The effects of IRE1, ATF6, and PERK signaling on adRP-linked rhodopsins. | Advances in experimental medicine and biology | 14 | 24664756 |
| 2021 | Upregulated monocyte expression of PLIN2 is associated with early arterial injury in children with overweight/obesity. | Atherosclerosis | 13 | 34044206 |
| 2023 | Effect on cell survival and cytoophidium assembly of the adRP-10-related IMPDH1 missense mutation Asp226Asn. | Frontiers in cell and developmental biology | 12 | 37731818 |
| 2023 | A missense variant in human perilipin 2 (PLIN2 Ser251Pro) reduces hepatic steatosis in mice. | JHEP reports : innovation in hepatology | 12 | 38074507 |
| 2016 | ARF1 activation dissociates ADRP from lipid droplets to promote HCV assembly. | Biochemical and biophysical research communications | 12 | 27157138 |
| 2015 | Increased ADRP expression in human atherosclerotic lesions correlates with plaque instability. | International journal of clinical and experimental medicine | 12 | 26131118 |
| 1990 | Further evidence of exclusion of linkage between type II autosomal dominant retinitis pigmentosa (ADRP) and D3S47 on 3q. | Genomics | 12 | 2081594 |
| 2024 | Downregulation of PLIN2 in human dermal fibroblasts impairs mitochondrial function in an age-dependent fashion and induces cell senescence via GDF15. | Aging cell | 11 | 38650174 |
| 2023 | Alcoholic Setdb1 suppression promotes hepatosteatosis in mice by strengthening Plin2. | Metabolism: clinical and experimental | 11 | 37419179 |
| 2021 | Transcriptomics analysis of Daheng broilers reveals that PLIN2 regulates chicken preadipocyte proliferation, differentiation and apoptosis. | Molecular biology reports | 11 | 34716501 |
| 2018 | Molecular Findings in Families with an Initial Diagnose of Autosomal Dominant Retinitis Pigmentosa (adRP). | Advances in experimental medicine and biology | 11 | 29721949 |
| 2005 | Mutational analysis of the rhodopsin gene in Chinese ADRP families by conformation sensitive gel electrophoresis. | Life sciences | 11 | 16229860 |
| 2018 | Expression of APOB, ADFP and FATP1 and their correlation with fat deposition in Yunnan's top six famous chicken breeds. | British poultry science | 10 | 30004246 |
| 2009 | The human ADFP gene is a direct liver-X-receptor (LXR) target gene and differentially regulated by synthetic LXR ligands. | Molecular pharmacology | 10 | 19843633 |
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