Affinage

PLEKHA7

Pleckstrin homology domain-containing family A member 7 · UniProt Q6IQ23

Length
1121 aa
Mass
127.1 kDa
Annotated
2026-06-10
36 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PLEKHA7 is a cytoplasmic adaptor protein that defines and stabilizes the apical adherens junction (zonula adhaerens) belt of polarized epithelial cells, where it is concentrated within ~28 nm of the plasma membrane alongside E-cadherin and p120-catenin but excluded from the lateral membrane and tight junction (PMID:20808826). It assembles a junctional scaffold through cooperative, multidomain interactions: its WW domains and central/C-terminal regions bind p120-catenin, paracingulin, and afadin to recruit these partners to the junction and drive proper AJ assembly (PMID:21454477, PMID:23990464), while its PH domain engages membrane phosphoinositides in a multivalent, clustering mode that is essential for junctional localization (PMID:33878292), and its WW, PH, and coiled-coil regions act in concert to target the protein to adherens junctions (PMID:34568338). A key effector branch is the recruitment of PDZD11 via cooperative engagement of the tandem WW domains, which stabilizes junctional nectins against proteasomal degradation and promotes junction assembly (PMID:27044745, PMID:32371390); the same PLEKHA7–PDZD11 module directs trafficking and localization of transmembrane transporters, supporting copper-induced peripheral targeting of the ATPase ATP7A and controlling the distribution and calcium-extrusion activity of the plasma membrane calcium pump PMCA (PMID:34613798, PMID:35714771). PLEKHA7 also shapes junctional actin dynamics, acting as a Rac1/Cdc42 GAP that stimulates GTP hydrolysis to maintain paracellular barrier integrity (PMID:29016860) and regulating cofilin activation through association with PP1α in a p120-catenin-dependent manner (PMID:26822694). Through its control of the junctional belt PLEKHA7 restrains tumor-promoting signaling and cell behavior: it suppresses E-cadherin/EGFR complex formation and downstream signaling (PMID:29996940) and limits ECM remodeling via miR-24/miR-30c-mediated control of MMP1 and LOX (PMID:38853930). Loss of PLEKHA7 at the apical belt drives neural progenitor delamination downstream of the Insm1 transcription factor (PMID:29503187) and contributes to salt-sensitive hypertension with impaired vascular function in vivo (PMID:25136115).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 2010 High

    Established that PLEKHA7 is a defining cytoplasmic component of the epithelial adherens junction belt rather than a general junctional or tight-junction protein, placing it spatially at the zonula adhaerens.

    Evidence Immunoelectron and immunofluorescence microscopy with immunoblotting/northern blotting across mammalian tissues and epithelial cell lines

    PMID:20808826

    Open questions at the time
    • Molecular partners anchoring it at this position not yet defined
    • Functional consequence of its junctional localization untested
  2. 2011 High

    Identified PLEKHA7 as a recruiter of cytoskeletal/junctional partners, showing it binds paracingulin and complexes with p120-catenin to organize junction composition.

    Evidence Yeast two-hybrid, GST pulldown, co-IP, and siRNA knockdown with immunofluorescence in MDCK cells

    PMID:21454477

    Open questions at the time
    • Did not define the full domain requirements for these interactions
    • Downstream functional output of paracingulin recruitment unresolved
  3. 2013 High

    Showed PLEKHA7 binds afadin and is recruited to nectin-based adhesion sites in a p120-independent, afadin-dependent manner, establishing multiple recruitment routes specific to AJ (not TJ) assembly.

    Evidence Co-IP, pulldown, dominant-negative expression, and KD/rescue immunofluorescence in EpH4 cells

    PMID:23990464

    Open questions at the time
    • Relative contributions of afadin versus p120 routes in vivo unknown
    • Structural basis of afadin binding not mapped
  4. 2014 Medium

    Linked PLEKHA7 to E-cadherin recruitment and barrier dynamics through microtubule-dependent mechanisms, and to a complex with ZO-1/cingulin.

    Evidence Inducible expression in MDCK cells, transepithelial resistance, calcium-switch and nocodazole treatments, co-IP

    PMID:24843844

    Open questions at the time
    • Mechanism connecting PLEKHA7 to microtubules at the molecular level unresolved
    • ZO-1/cingulin association is correlative without direct binding mapping
  5. 2014 High

    Demonstrated an in vivo physiological role: PLEKHA7 loss-of-function attenuates salt-sensitive hypertension and improves vascular function, connecting the junctional adaptor to systemic blood pressure regulation.

    Evidence Zinc-finger nuclease editing in Dahl salt-sensitive rats with telemetric BP, myography, histology, and calcium imaging

    PMID:25136115

    Open questions at the time
    • Mechanistic link between junctional function and vascular calcium/NO handling not established
    • Cell type driving the hypertension phenotype not pinpointed
  6. 2016 High

    Identified PDZD11 as a WW-domain-bound effector that PLEKHA7 recruits to junctions to stabilize nectins and promote junction assembly, defining a major output branch.

    Evidence Yeast two-hybrid, MS of immunoprecipitates, GST pulldown, CRISPR KO, immunofluorescence, calcium-switch assay

    PMID:27044745

    Open questions at the time
    • Structural detail of the WW-PDZD11 interface not yet resolved
    • Whether PDZD11 mediates additional PLEKHA7 functions unknown
  7. 2016 Medium

    Connected PLEKHA7 to junctional actin regulation, showing it controls cofilin activation via association with PP1α phosphatase in a p120-dependent manner.

    Evidence Co-IP, immunoblotting after KD/KO, phospho-cofilin assays, proteomics of immunoprecipitates

    PMID:26822694

    Open questions at the time
    • Direct versus indirect PLEKHA7-PP1α binding not distinguished
    • Single-lab study without reciprocal validation
  8. 2017 Medium

    Assigned an enzymatic activity to PLEKHA7 as a Rac1/Cdc42 GAP, providing a mechanism by which it shapes actin organization and paracellular barrier integrity.

    Evidence Co-IP with GTP/GDP-loaded GTPases, in vitro GTP hydrolysis assay, siRNA KD with TER and actin readouts in ciliary epithelial cells

    PMID:29016860

    Open questions at the time
    • GAP domain within PLEKHA7 not mapped
    • Whether GAP activity operates at the junction in vivo untested
  9. 2018 High

    Placed PLEKHA7 downstream of Insm1 as a controller of apical junction belt integrity in neural progenitors, where its loss alone drives delamination and apical-to-basal conversion.

    Evidence CRISPR/Cas9 KO and in utero electroporation overexpression in mouse neocortex with Insm1 epistasis

    PMID:29503187

    Open questions at the time
    • Whether junctional partners mediate the delamination phenotype not tested
    • Link to broader developmental outcomes unresolved
  10. 2018 Medium

    Established a tumor-suppressive function: PLEKHA7 limits E-cadherin/EGFR complex formation and downstream CDK5 signaling to reduce tumorigenicity.

    Evidence Lentiviral overexpression, co-IP of E-cadherin-EGFR, EGFR phospho-immunoblotting, 3D growth assays in ovarian cancer cells

    PMID:29996940

    Open questions at the time
    • Loss-of-function (rather than overexpression) effects on EGFR not tested here
    • Single-lab study
  11. 2020 Medium

    Resolved how the tandem WW domains cooperatively bind PDZD11 and how PDZD11 binding allosterically licenses tetraspanin 33 engagement, defining the structural logic of WW-mediated partner recruitment.

    Evidence Site-directed mutagenesis, GST pulldown, immunofluorescence, molecular modeling and docking

    PMID:32371390

    Open questions at the time
    • No experimental high-resolution structure of the WW-PDZD11 complex
    • Functional role of tetraspanin 33 recruitment untested
  12. 2021 High

    Defined the PH domain as a multivalent PIP-clustering module required for PLEKHA7 localization, identifying residue D175 as a lipid-selectivity sentry.

    Evidence X-ray crystallography, NMR, MD simulations, ITC, and site-directed mutagenesis

    PMID:33878292

    Open questions at the time
    • How PIP clustering integrates with protein-protein junctional anchoring not resolved
    • In vivo relevance of lipid selectivity untested
  13. 2021 Medium

    Showed multidomain cooperation (WW, PH, C-terminal/coiled-coil) jointly determines AJ targeting and that the WW-PDZD11 interaction underlies microtubule association in the WW-PLEKHA family.

    Evidence Domain-swap and deletion analysis of chimeric WW-PLEKHA proteins with immunofluorescence in epithelial cells

    PMID:34568338

    Open questions at the time
    • Quantitative contribution of each domain to anchoring not dissected
    • Microtubule link shown for PLEKHA5 rather than PLEKHA7 directly
  14. 2021 High

    Extended the PLEKHA7-PDZD11 module to transmembrane transporter trafficking, showing it is required for copper-induced peripheral targeting of ATP7A and maintenance of low intracellular copper.

    Evidence CRISPR-KO, pulldown, surface biotinylation, copper measurement, and viability assays

    PMID:34613798

    Open questions at the time
    • Mechanism of how the complex directs ATP7A trafficking not detailed
    • Whether junctional pool versus other pools mediates this unresolved
  15. 2021 Medium

    Identified a PH-domain-dependent interaction with wild-type KRas and showed PH-domain inhibition selectively impairs mutant-KRas cell growth and tumor formation.

    Evidence FLIM-FRET, siRNA/pharmacological PH-domain inhibition, proliferation/migration/attachment assays, in vivo tumor growth

    PMID:34800542

    Open questions at the time
    • Mechanism reconciling WT-KRas binding with mutant-KRas dependence unclear
    • Single-lab study
  16. 2022 High

    Demonstrated that the PLEKHA7-PDZD11 complex controls PMCA localization and calcium-extrusion activity, with PDZ-binding-motif specificity, linking the junctional scaffold to calcium homeostasis.

    Evidence CRISPR-KO, immunofluorescence, surface biotinylation, cytosolic calcium transient measurements, PDZD11 co-expression in HeLa cells

    PMID:35714771

    Open questions at the time
    • Physiological consequence of altered PMCA calcium extrusion in epithelia untested
    • Connection to the hypertension calcium phenotype not directly established
  17. 2023 Medium

    Showed transcriptional silencing of PLEKHA7 by an hTERT-p50 dimer drives gastric cancer invasion and metastasis in a PLEKHA7-dependent manner, establishing a regulatory input controlling its tumor-suppressive output.

    Evidence ChIP, co-IP, siRNA KD, invasion/migration assays, and overexpression rescue

    PMID:36823376

    Open questions at the time
    • Whether this regulation occurs in non-gastric tissues unknown
    • Mechanistic link from PLEKHA7 loss to invasion not fully resolved here
  18. 2024 Medium

    Connected PLEKHA7 to ECM remodeling through miR-24/miR-30c control of MMP1 and LOX, providing a mechanism for invasion downstream of PLEKHA7 loss.

    Evidence siRNA/KO depletion, miRNA quantification, MMP1/LOX activity assays, 3D culture, in vivo mouse colonic lamina propria analysis (preprint)

    PMID:38853930

    Open questions at the time
    • Preprint not yet peer-reviewed
    • How junctional PLEKHA7 controls miRNA levels mechanistically unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PLEKHA7's distinct activities — junctional scaffolding, Rho-family GAP activity, PIP clustering, transporter trafficking, and miRNA/transcriptional regulation — are coordinated into a single integrated function, and whether they operate from the same junctional pool, remains unresolved.
  • No unified model linking GAP activity, lipid binding, and transporter trafficking
  • No high-resolution structure of full-length PLEKHA7 or its junctional complex
  • Tissue-specific functions not systematically compared

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 5 GO:0008092 cytoskeletal protein binding 2 GO:0098772 molecular function regulator activity 2 GO:0008289 lipid binding 1
Localization
GO:0005856 cytoskeleton 2 GO:0005886 plasma membrane 2 GO:0005829 cytosol 1
Pathway
R-HSA-1500931 Cell-Cell communication 3 R-HSA-162582 Signal Transduction 3 R-HSA-382551 Transport of small molecules 2 R-HSA-1474244 Extracellular matrix organization 1
Partners
AFADIN (AFDN)ATP7AKRASP120-CATENIN (CTNND1)PARACINGULIN (CGNL1)PDZD11PMCA4PP1Α
Complex memberships
PLEKHA7-PDZD11 complexadherens junction belt (zonula adhaerens)

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 PLEKHA7 is a cytoplasmic component of the epithelial adherens junction (AJ) belt, localized at a mean distance of ~28 nm from the plasma membrane, concentrated in the apical junctional belt similarly to E-cadherin and p120-ctn but unlike ZO-1, and not extending along the lateral region of polarized epithelial cells. Immunoelectron microscopy, immunofluorescence microscopy, immunoblotting, northern blotting in mammalian tissues and cultured epithelial cells PloS one High 20808826
2011 PLEKHA7 directly interacts with paracingulin (through a central region of PLEKHA7 binding the globular head domain of paracingulin) and forms a complex with p120-ctn; depletion of PLEKHA7 from MDCK cells results in loss of junctional localization of paracingulin and decreased paracingulin expression, identifying PLEKHA7 as a recruiter of paracingulin to adherens junctions. Yeast two-hybrid screen, GST pulldown, co-immunoprecipitation, siRNA knockdown with immunofluorescence The Journal of biological chemistry High 21454477
2013 PLEKHA7 binds directly to afadin (in addition to p120-ctn) and is recruited to nectin-3α-based cell-cell adhesion sites in an afadin-dependent but p120-ctn-independent manner; this PLEKHA7-afadin binding is required for proper AJ formation but not tight junction formation in epithelial cells. Co-immunoprecipitation, pulldown, expression of dominant-negative constructs, immunofluorescence in EpH4 cells with KD/rescue experiments The Journal of biological chemistry High 23990464
2014 PLEKHA7 forms a complex with the cytoplasmic TJ proteins ZO-1 and cingulin (by co-immunoprecipitation), and inducible expression of PLEKHA7 constructs enhances E-cadherin recruitment at the apical zonula adhaerens and modulates TJ barrier dynamics (decreased TER at 18 h post-assembly; attenuated TER fall after calcium removal) through microtubule-dependent mechanisms. Inducible expression in MDCK cells, transepithelial resistance measurements, calcium-switch assay, nocodazole treatment, co-immunoprecipitation Tissue barriers Medium 24843844
2014 Zinc-finger nuclease-mediated mutation of Plekha7 in Dahl salt-sensitive rats attenuates salt-sensitive hypertension, reduces total peripheral resistance and perivascular fibrosis, and improves endothelium-dependent vasodilation, correlated with changes in intracellular calcium handling and increased nitric oxide bioavailability in mutant vessels. Zinc-finger nuclease gene editing in rat model, telemetric blood pressure measurement, myography of isolated mesenteric arteries, histology, calcium imaging Proceedings of the National Academy of Sciences of the United States of America High 25136115
2016 PLEKHA7 recruits PDZD11 to adherens junctions via a direct interaction between the N-terminal WW domain of PLEKHA7 and the N-terminal 44 amino acids of PDZD11 (shown by GST pulldown); PLEKHA7 KO abolishes junctional PDZD11 localization; the PLEKHA7-PDZD11 complex stabilizes nectin-1 and nectin-3 (preventing proteasome-mediated degradation) and promotes efficient early junction assembly in the calcium-switch model. Yeast two-hybrid, mass spectrometry of PLEKHA7 immunoprecipitates, GST pulldown, co-immunoprecipitation, CRISPR/Cas9 KO, immunofluorescence, calcium-switch assay The Journal of biological chemistry High 27044745
2016 PLEKHA7 loss activates the actin regulator cofilin in a p120-catenin-dependent manner; PLEKHA7 associates with and regulates levels of PP1α phosphatase, which is responsible for cofilin activation, linking PLEKHA7 to cortical actin ring dynamics at the apical zonula adhaerens. Co-immunoprecipitation, immunoblotting after KD/KO, phospho-cofilin assays, proteomics of PLEKHA7 immunoprecipitates Cell cycle (Georgetown, Tex.) Medium 26822694
2017 PLEKHA7 specifically interacts with GTP-bound Rac1 and Cdc42 (but not RhoA) and stimulates their GTP hydrolysis without affecting nucleotide exchange, identifying PLEKHA7 as a novel Rac1/Cdc42 GAP; silencing PLEKHA7 compromises paracellular barrier integrity in non-pigmented ciliary epithelial cells and affects actin cytoskeleton organization. Co-immunoprecipitation with GTP/GDP-loaded GTPases, GTP hydrolysis assay, siRNA knockdown with transepithelial resistance and actin staining readouts Human molecular genetics Medium 29016860
2018 Insm1 transcription factor represses Plekha7 expression in neural progenitor cells; CRISPR/Cas9-mediated disruption of Plekha7 alone is sufficient to cause NPC delamination from the ventricular surface, converting apical to basal radial glia; Plekha7 overexpression impedes NPC delamination and counteracts Insm1-induced delamination, placing Plekha7 downstream of Insm1 in control of adherens junction belt integrity. CRISPR/Cas9 KO in mouse neocortex, in utero electroporation overexpression, immunofluorescence, Insm1 forced expression experiments Neuron High 29503187
2018 PLEKHA7 overexpression reduces formation of the E-cadherin-EGFR complex, decreases EGFR activation and downstream CDK5 signaling, and reduces cell tumorigenicity in ovarian cancer cells, demonstrating that PLEKHA7 negatively regulates E-cadherin/EGFR crosstalk. Lentiviral PLEKHA7 overexpression, co-immunoprecipitation of E-cadherin-EGFR complex, EGFR phosphorylation immunoblotting, 3D growth assays, confocal microscopy Journal of experimental & clinical cancer research : CR Medium 29996940
2020 The tandem WW domains of PLEKHA7 cooperatively bind PDZD11: Asp-30 of WW1 and His-75 of WW2 form a hydrogen bond and together with Thr-35 of WW1 create a binding pocket for a polyproline stretch in PDZD11; WW2 stabilizes WW1 and promotes PDZD11 binding; PDZD11 binding induces a conformational rearrangement that expands a hydrophobic hot spot on WW1, enabling tetraspanin 33 (via its C-terminal Trp-283/Tyr-282) to bind the WW1 hydrophobic surface. Site-directed mutagenesis, GST pulldown, immunofluorescence, molecular modeling and docking The Journal of biological chemistry Medium 32371390
2021 PLEKHA5, PLEKHA6, and PLEKHA7 (WW-PLEKHAs) interact with PDZD11 through their WW domains and are required for efficient anterograde targeting of the Menkes ATPase ATP7A to the cell periphery under elevated copper; CRISPR-KO of WW-PLEKHAs reduces peripheral ATP7A localization; WW-PLEKHAs and PDZD11 are required for maintaining low intracellular copper levels under elevated copper conditions. CRISPR-KO, pulldown, immunofluorescence microscopy, surface biotinylation, copper measurement, cell viability assays, metallothionein-1 expression Molecular biology of the cell High 34613798
2021 The PH domain of PLEKHA7 directly interacts with membrane-embedded phosphatidylinositol lipids (PIPs) in a multivalent manner that induces PIP clustering, distinct from discrete one-to-one binding; residue D175 acts as a 'sentry' preventing PI(3,4)P2 and PI(3,4,5)P3 binding; this PH domain-lipid interaction is critical for PLEKHA7 cellular localization and function. X-ray crystallography, NMR, molecular dynamics simulations, isothermal titration calorimetry, site-directed mutagenesis Structure (London, England : 1993) High 33878292
2021 The WW domain, PH domain, and C-terminal/coiled-coil regions of PLEKHA7 cooperate to determine its subcellular localization at adherens junctions: the PH domain of PLEKHA7 promotes AJ localization in chimeric proteins, the C-terminal and coiled-coil regions promote AJ localization, and the WW-PDZD11 interaction is required for microtubule association of PLEKHA5. Expression of mutant and chimeric WW-PLEKHA proteins in cultured epithelial cells, immunofluorescence microscopy Frontiers in cell and developmental biology Medium 34568338
2021 PLEKHA7 directly interacts with wild-type KRas (but scantily with mutant KRas) as shown by FLIM-FRET; inhibiting the PLEKHA7 PH domain (molecularly or pharmacologically) specifically decreases mutant-KRas cell signaling, proliferation, attachment, migration, and tumor growth, but not wild-type KRas cells. FLIM-FRET, siRNA/pharmacological inhibition of PH domain, proliferation/migration/attachment assays, in vivo tumor growth Experimental cell research Medium 34800542
2022 PLEKHA7-PDZD11 complex regulates the localization of the plasma membrane calcium ATPase PMCA: KO of PLEKHA7 or PDZD11 increases PMCA accumulation at lateral cell-cell contacts and causes ectopic apical localization of PMCA4x/b; PDZD11 counteracts calcium extrusion activity of PMCA4x/b (but not PMCA4x/a lacking the PDZ-binding motif); KO of PDZD11 increases the rate of calcium extrusion. CRISPR-KO, immunofluorescence, surface biotinylation, cytosolic calcium transient measurements, PDZD11 co-expression in HeLa cells The Journal of biological chemistry High 35714771
2023 The hTERT-p50 homodimer directly binds the PLEKHA7 promoter and represses PLEKHA7 transcription; increased hTERT decreases PLEKHA7 expression and promotes invasion and metastasis in gastric cancer cells in a PLEKHA7-dependent manner. ChIP assay (hTERT/p50 binding to PLEKHA7 promoter), co-immunoprecipitation, siRNA knockdown, invasion/migration assays, overexpression rescue experiments Oncogene Medium 36823376
2024 PLEKHA7 regulates ECM remodeling by controlling levels and activity of MMP1 and LOX through miR-24 and miR-30c miRNAs; PLEKHA7 depletion causes LOX-dependent ECM remodeling in culture and in the colonic mucosal lamina propria in mice; PLEKHA7-depleted cells show increased migration and invasion that are MMP1- and LOX-dependent. siRNA/KO depletion, miRNA quantification, MMP1/LOX activity assays, 3D culture, in vivo mouse colonic lamina propria analysis, migration/invasion assays with pharmacological rescue bioRxivpreprint Medium 38853930

Source papers

Stage 0 corpus · 36 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 PLEKHA7 is an adherens junction protein with a tissue distribution and subcellular localization distinct from ZO-1 and E-cadherin. PloS one 75 20808826
2018 Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7. Neuron 66 29503187
2011 A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells. The Journal of biological chemistry 57 21454477
2011 Genetic variations in CYP17A1, CACNB2 and PLEKHA7 are associated with blood pressure and/or hypertension in She ethnic minority of China. Atherosclerosis 56 21963141
2014 Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. Proceedings of the National Academy of Sciences of the United States of America 51 25136115
2012 Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex. Annals of the New York Academy of Sciences 51 22671598
2013 Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells. The Journal of biological chemistry 49 23990464
2014 PLEKHA7 modulates epithelial tight junction barrier function. Tissue barriers 39 24843844
2021 PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis. Molecular biology of the cell 36 34613798
2016 PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins. The Journal of biological chemistry 27 27044745
2014 Extended association study of PLEKHA7 and COL11A1 with primary angle closure glaucoma in a Han Chinese population. Investigative ophthalmology & visual science 27 24854855
2016 PLEKHA7: Cytoskeletal adaptor protein at center stage in junctional organization and signaling. The international journal of biochemistry & cell biology 26 27072621
2018 Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth. Journal of experimental & clinical cancer research : CR 24 29996940
2020 ALK-rearranged renal cell carcinoma with a novel PLEKHA7-ALK translocation and metanephric adenoma-like morphology. Virchows Archiv : an international journal of pathology 23 31993771
2014 Expression of the primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 in endothelial and epithelial cell junctions in the eye. Investigative ophthalmology & visual science 22 24801512
2016 PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications. Cell cycle (Georgetown, Tex.) 21 26822694
2017 Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function. Human molecular genetics 20 29016860
2021 Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids. Structure (London, England : 1993) 18 33878292
2021 WW, PH and C-Terminal Domains Cooperate to Direct the Subcellular Localizations of PLEKHA5, PLEKHA6 and PLEKHA7. Frontiers in cell and developmental biology 18 34568338
2015 The Expression of the Zonula Adhaerens Protein PLEKHA7 Is Strongly Decreased in High Grade Ductal and Lobular Breast Carcinomas. PloS one 17 26270346
2012 Genetic up-regulation and overexpression of PLEKHA7 differentiates invasive lobular carcinomas from invasive ductal carcinomas. Human pathology 12 22542108
2021 PLEKHA7, an Apical Adherens Junction Protein, Suppresses Inflammatory Breast Cancer in the Context of High E-Cadherin and p120-Catenin Expression. International journal of molecular sciences 10 33525380
2020 Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33. The Journal of biological chemistry 9 32371390
2021 PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer. Experimental cell research 7 34800542
2022 Origin and Evolution of the Multifaceted Adherens Junction Component Plekha7. Frontiers in cell and developmental biology 6 35399503
2022 The PLEKHA7-PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells. The Journal of biological chemistry 6 35714771
2021 Genetic Markers PLEKHA7, ABCC5, and KALRN Are Not Associated With the Progression of Primary Angle Closure Glaucoma (PACG) in Malays. Cureus 6 34804680
2024 Concomitant double-fusion of PLEKHA7-ALK and INPP5D-ALK reveals favorable alectinib sensitivity in lung adenocarcinoma: a case report and literature review. Discover oncology 5 38379102
2024 The epithelial adherens junction component PLEKHA7 regulates ECM remodeling and cell behavior through miRNA-mediated regulation of MMP1 and LOX. bioRxiv : the preprint server for biology 5 38853930
2024 A novel double fusion of EML4-ALK and PLEKHA7-ALK contribute to rapid progression of lung adenocarcinoma: a case report and literature review. Discover oncology 2 39522087
2023 The hTERT-p50 homodimer inhibits PLEKHA7 expression to promote gastric cancer invasion and metastasis. Oncogene 2 36823376
2022 Impact of rs11024102 PLEKHA7, rs3753841 COL11A1 single nucleotide polymorphisms, and serum levels of oxidative stress markers on the risk of primary angle-closure glaucoma in Egyptians. Journal, genetic engineering & biotechnology 2 36036827
2016 [Association of PLEKHA7, COL11A1 and PCMTD1-ST18 gene polymorphisms with primary angle closure glaucoma in ethnic Han Chinese from Sichuan]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2 27455018
2025 Genetic association of single nucleotide polymorphisms in PLEKHA7 gene with primary angle closure glaucoma (PACG) in a Central-Eastern Punjab cohort of Pakistan. Molecular biology reports 1 39903387
2025 Role of PLEKHA7 in promoting radioresistance in esophageal cancer cells via the inhibition of cuproptosis. Journal of thoracic disease 1 40688283
2022 Bioengineered PLEKHA7 nanodelivery regularly induces behavior alteration and growth retardation of acute myeloid leukemia. Biomaterials and biosystems 1 36824159

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