Affinage

PIEZO1

Piezo-type mechanosensitive ion channel component 1 · UniProt Q92508

Length
2521 aa
Mass
286.8 kDa
Annotated
2026-06-10
100 papers in source corpus 43 papers cited in narrative 43 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PIEZO1 is a pore-forming, mechanically activated, calcium-permeable cation channel that transduces membrane tension and mechanical deformation into cellular calcium signals across diverse tissues (PMID:20813920). Its gating is intrinsic to the protein and to its lipid environment: cryo-EM in liposomes shows the channel adopts a curved resting state that flattens (~300 nm² in-plane area expansion) under membrane tension to open the conduction pathway, with a calculated half-maximal gating tension (~1.9 pN/nm) matching experiment (PMID:35388220), and single-molecule imaging in live cells confirms that the blades are bent by resting membrane stress and expand upon activation (PMID:37587339). Membrane mechanics tune sensitivity directly — saturating versus polyunsaturated fatty acids modulate activation and inactivation by altering bilayer bending stiffness (PMID:30867417) — while the synthetic agonist Yoda1 activates purified channels reconstituted in lipid bilayers and the peptide GsMTx4 inhibits gating as a membrane-mediated modifier (PMID:26001275, PMID:21696149). At the cellular level, PIEZO1 couples mechanical input to calcium-dependent effectors that are interpreted in a cell-type-specific manner: in erythrocytes stretch-driven calcium influx engages the KCa3.1 Gardos channel to control cell volume and TMEM16F to drive phosphatidylserine exposure (PMID:26001274, PMID:38033286); in fibroblasts, tubular, and myeloid cells calcium activates calpain-mediated talin cleavage, integrin β1, and YAP/TAZ signaling to drive adhesion, fibrosis, and macrophage polarization (PMID:35230979, PMID:40454481, PMID:38556840); and in endothelial and lymphatic cells shear stress activates PIEZO1 to control junction formation, leukocyte diapedesis, and the Orai1–KLF2–Notch and ANGPT2/TIE1 mechanotransduction networks (PMID:37005489, PMID:35443048, PMID:35701867, PMID:38747287). PIEZO1 also acts as a chemo-mechanosensor — sensing microbial single-stranded RNA in gut enterochromaffin cells to govern serotonin output (PMID:32640190) — and broadly couples mechanical stimulation to paracrine release of ATP, FGF1, and other ligands (PMID:31780935, PMID:32385276, PMID:35963237). Gain-of-function mutations in PIEZO1 cause hereditary xerocytosis, a dominant hemolytic anemia with erythrocyte dehydration (PMID:22529292).

Mechanistic history

Synthesis pass · year-by-year structured walk · 19 steps
  1. 2010 High

    Established the molecular identity of a long-sought mechanically activated cation channel, answering whether a single gene product could constitute a mechanosensor.

    Evidence RNAi knockdown and overexpression with patch-clamp electrophysiology in neuroblastoma and HEK293 cells

    PMID:20813920

    Open questions at the time
    • Did not resolve the channel's oligomeric state or structural basis of gating
    • Endogenous physiological force inputs not defined
  2. 2010 Medium

    Proposed an early intracellular role linking Fam38A/Piezo1 to integrin activation via an ER-localized R-Ras/calpain/talin cascade, distinct from later plasma-membrane mechanosensing.

    Evidence siRNA knockdown, subcellular fractionation, co-IP, and pharmacological epistasis in adherent cells

    PMID:20016066

    Open questions at the time
    • ER localization is hard to reconcile with later plasma-membrane channel function
    • Whether calcium release was from ER stores versus extracellular influx not definitively resolved
  3. 2011 High

    Characterized GsMTx4 as a membrane-mediated gating modifier, providing a pharmacological tool and evidence that gating is sensitive to bilayer mechanics rather than a stereospecific binding pocket.

    Evidence Patch-clamp with pressure-gating curves, enantiomer controls, and kinetic analysis in Piezo1-expressing HEK293 cells

    PMID:21696149

    Open questions at the time
    • Molecular site of action on the channel/membrane not mapped
    • Selectivity versus other mechanosensitive channels limited
  4. 2012 High

    Linked PIEZO1 to human disease, showing gain-of-function mutations cause hereditary xerocytosis and confirming PIEZO1 is an endogenous erythrocyte membrane protein.

    Evidence Linkage, exome sequencing, segregation in kindreds, and erythrocyte membrane proteomics

    PMID:22529292

    Open questions at the time
    • Did not establish the downstream effector linking channel hyperactivity to dehydration
    • Mutation effects on gating biophysics not yet measured
  5. 2014 High

    Defined PIEZO1 as the endothelial shear-stress sensor required for vascular development and flow-induced cytoskeletal remodeling.

    Evidence Endothelial-specific conditional knockout mice with shear stress, cell orientation, and stress fiber assays

    PMID:24958852

    Open questions at the time
    • Downstream signaling from calcium influx to cytoskeletal reorganization not detailed
    • Embryonic lethality limited adult vascular analysis
  6. 2015 High

    Provided a synthetic agonist (Yoda1) acting directly on purified channels and resolved the erythrocyte volume-control pathway downstream of PIEZO1.

    Evidence Compound screening with bilayer reconstitution of purified Piezo1; RBC-specific knockout with calcium imaging and Gardos channel pharmacology

    PMID:26001274 PMID:26001275

    Open questions at the time
    • Yoda1 binding site and activation mechanism not structurally defined in 2015
    • Direct coupling between PIEZO1 calcium and Gardos channel not molecularly mapped
  7. 2017 High

    Connected mechanical stretch to cell-cycle progression, showing PIEZO1 drives calcium-ERK-cyclin B signaling and changes localization with cell density.

    Evidence Epithelial stretch, calcium imaging, phospho-ERK and cyclin B assays, knockdown, and live-cell PIEZO1 imaging

    PMID:28199303

    Open questions at the time
    • Mechanism of density-dependent cytoplasmic aggregation unresolved
    • Link between calcium and ERK activation not molecularly defined
  8. 2019 High

    Established PIEZO1 as a tunable sensor whose set-point is controlled by membrane lipid composition, with therapeutic implications for gain-of-function disease.

    Evidence Lipid profiling, electrophysiology, AFM membrane stiffness measurement, and fatty acid rescue of GOF mutant phenotypes

    PMID:30867417

    Open questions at the time
    • Whether dietary modulation translates to patients not addressed
    • Distinct lipid effects on activation versus inactivation not fully separated mechanistically
  9. 2019 High

    Defined PIEZO1 as the osteogenic mechanosensor coupling mechanical loading to bone formation, and demonstrated pharmacological gain-of-function increases bone mass.

    Evidence Osteoblast/osteocyte-specific conditional knockouts, fluid shear assays, microgravity simulation, and in vivo Yoda1 administration

    PMID:31290742 PMID:31588901

    Open questions at the time
    • Downstream transcriptional program in bone cells not fully resolved here
    • Relative contributions of osteoblasts versus osteocytes not separated
  10. 2020 High

    Showed PIEZO1 couples mechanosensing to paracrine ligand release, driving FGF1-dependent adipogenesis and microbial ssRNA-dependent serotonin production in the gut.

    Evidence Adipocyte- and intestinal-epithelium-specific conditional knockouts, FGF1/FGFR1 dissection, ssRNA ligand identification, and RNase A infusion

    PMID:32385276 PMID:32640190

    Open questions at the time
    • How PIEZO1 detects ssRNA chemically versus mechanically not resolved
    • Generalizability of ligand-release coupling across tissues unclear
  11. 2021 High

    Implicated PIEZO1 in macrophage-mediated erythrocyte turnover and systemic iron metabolism via hepcidin control, with a common human GOF allele influencing plasma iron.

    Evidence Constitutive and macrophage-specific GOF knock-in mice with hepcidin and iron assays plus human genetic association

    PMID:33571427

    Open questions at the time
    • Mechanism linking macrophage PIEZO1 activity to hepcidin not fully resolved
    • Causal mechanical input to macrophage PIEZO1 in vivo undefined
  12. 2022 High

    Resolved the structural basis of gating, showing tension-driven flattening of the curved channel quantitatively accounts for activation tension.

    Evidence Cryo-EM of PIEZO1 in liposomes capturing curved and flattened states with in-plane area and stiffness calculations

    PMID:35388220

    Open questions at the time
    • Conformational pathway between states not kinetically resolved
    • Lipid and modifier binding sites not mapped in the structures
  13. 2022 High

    Mapped the molecular machinery directing PIEZO1 to endothelial junctions, identifying PECAM1 and shear-responsive CDH5 as direct partners while excluding VEGFR2.

    Evidence Native-tagged PIEZO1 mice, reconstitution, reciprocal co-IP, high-resolution colocalization, and shear stress assays

    PMID:37005489

    Open questions at the time
    • Functional consequence of junctional targeting for channel gating not fully defined
    • Stoichiometry of PIEZO1-PECAM1/CDH5 complexes unknown
  14. 2022 High

    Expanded PIEZO1's vascular and inflammatory repertoire, defining its role in leukocyte diapedesis, capillary mechanosensing, lymphatic mechanotransduction, and mitochondrial OXPHOS.

    Evidence Endothelial/lymphatic conditional knockouts, capillary electrophysiology, Orai1 epistasis, phospho-signaling cascades, and Seahorse metabolic assays

    PMID:35382561 PMID:35443048 PMID:35701867 PMID:36052712

    Open questions at the time
    • Multiple parallel downstream cascades not integrated into a single regulatory logic
    • Tissue-specific determinants of which effector is engaged unresolved
  15. 2023 High

    Revealed that PIEZO1 blades are more expanded at rest in native membranes than predicted, refining the relationship between blade conformation and channel state in living cells.

    Evidence Single-molecule nanoscopic fluorescence imaging of endogenously tagged PIEZO1 with chemical and mechanical modulators

    PMID:37587339

    Open questions at the time
    • Quantitative link between blade expansion and open probability not established
    • Native-cell forces shaping resting curvature not measured directly
  16. 2023 High

    Defined quantitative biophysical gating thresholds in chondrocytes and established membrane stretch as the proximate gating stimulus.

    Evidence Single-cell AFM compression with finite element modeling, calcium imaging, and PIEZO1/2 knockout

    PMID:37459546

    Open questions at the time
    • Translation of stretch ratio threshold to physiological joint loading unclear
    • Contribution of PIEZO2 versus PIEZO1 at lower strains not fully separated
  17. 2023 High

    Connected PIEZO1 to immune effector mechanics and named downstream signaling networks, including neutrophil NOX4 bactericidal activity, NETosis, EGFR-ERK activation, and lymphatic ANGPT2/TIE1 signaling.

    Evidence PMN-, neutrophil-, and lymphatic-targeted manipulation with intravital imaging, microfluidics, phospho-site analysis, and conditional knockouts

    PMID:37756411 PMID:38091995 PMID:38747287 PMID:39174529

    Open questions at the time
    • Whether these cascades share a common proximal calcium-effector module is unresolved
    • Some signaling links derive from single-lab pharmacology
  18. 2024 High

    Identified TMEM16F as the PIEZO1-coupled phosphatidylserine scramblase in erythrocytes and defined PIEZO1 roles in adaptive and innate immune effector programs.

    Evidence Calcium/PS exposure assays in normal and HX RBCs, traction force microscopy in T cells, and ILC2/macrophage conditional knockouts

    PMID:38033286 PMID:38514773 PMID:38530239 PMID:38838160

    Open questions at the time
    • Physical coupling between PIEZO1 and TMEM16F not structurally defined
    • Cell-type determinants selecting GRHL3/RNF114 versus KLF2 versus YAP outputs unclear
  19. 2025 Medium

    Extended PIEZO1 into fibrotic, metabolic, and aneurysmal disease, dissecting YAP/TAZ-dependent myofibroblast activation, calpain/Drp1 mitochondrial fission, and TGFBR2 trafficking via Rab3C.

    Evidence Cell-type-specific conditional knockouts with epistasis (Yap/Taz KO), TGFBR2 endocytosis/autophagy assays, and Yoda1 in vivo treatment

    PMID:39585648 PMID:39932793 PMID:40114130 PMID:40454481

    Open questions at the time
    • Most disease mechanisms rest on single-lab studies
    • How a single channel selects opposing pro- versus anti-fibrotic outputs across cell types unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • The unifying logic by which a single tension sensor is interpreted into divergent, sometimes opposing, cell-type-specific transcriptional and metabolic programs remains unresolved.
  • No general model links calcium amplitude/kinetics to choice of downstream effector (Gardos, calpain, YAP, ERK, etc.)
  • Direct partners beyond PECAM1/CDH5 that route output are largely unmapped
  • Structural basis of chemical ligand (ssRNA) versus mechanical sensing not resolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 5 GO:0140299 molecular sensor activity 4 GO:0060089 molecular transducer activity 3
Localization
GO:0005886 plasma membrane 5 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-168256 Immune System 5 R-HSA-1266738 Developmental Biology 4 R-HSA-8953897 Cellular responses to stimuli 2
Partners
CDH5KCNN4ORAI1PECAM1RRASTMEM16FTRPC6

Evidence

Reading pass · 43 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 Piezo1 (Fam38A) is an essential component of a mechanically activated (MA) cation channel. RNA interference knockdown of Piezo1 eliminated rapidly adapting MA currents in a mouse neuroblastoma cell line, and overexpression of mouse Piezo1 induced a kinetically distinct MA current, establishing Piezo1 as a pore-forming component of an MA cation channel. RNAi knockdown, overexpression, whole-cell and outside-out patch-clamp electrophysiology Science High 20813920
2011 The peptide GsMTx4 reversibly inhibits Piezo1-mediated mechanically activated currents in outside-out and whole-cell configurations, acting as a gating modifier (voltage-insensitive, active on closed channels) that shifts the pressure-gating curve ~30 mmHg rightward, with KD ~155 nM. The d-enantiomer was equally effective, consistent with membrane-mediated inhibition rather than stereospecific binding. Outside-out and whole-cell patch-clamp electrophysiology in HEK293 cells overexpressing Piezo1; kinetic rate-constant analysis Biochemistry High 21696149
2010 Fam38A/Piezo1 localizes to the endoplasmic reticulum (ER) and activates integrin-ligand affinity by recruiting the small GTPase R-Ras to the ER, which increases Ca2+ release from cytoplasmic stores, activates calpain, and leads to talin cleavage. siRNA knockdown of Fam38A inactivates β1 integrin and reduces cell adhesion; this pathway is blocked by inhibition of R-Ras, calpain, or talin knockdown. siRNA knockdown, subcellular fractionation/immunofluorescence localization to ER, cell adhesion assays, pharmacological inhibition of R-Ras and calpain, co-immunoprecipitation Journal of Cell Science Medium 20016066
2012 Gain-of-function mutations in PIEZO1 (FAM38A) cause hereditary xerocytosis (HX), an autosomal dominant hemolytic anemia with primary erythrocyte dehydration. PIEZO1 peptides were identified by discovery proteomics in human erythrocyte membranes, establishing Piezo1 as an endogenous erythrocyte membrane protein. Copy number analysis, linkage studies, exome sequencing, segregation analysis, discovery proteomics of erythrocyte membranes Blood High 22529292
2014 Piezo1 is expressed in endothelial cells of developing blood vessels and is activated by shear stress. Endothelial-specific Piezo1 deletion is embryonic lethal with vascular remodeling defects, and loss of Piezo1 impairs shear-stress-induced stress fiber formation and cell orientation, linking Piezo1 mechanotransduction to regulation of endothelial cell morphology. Conditional endothelial-specific knockout mice, shear stress application, cell orientation and stress fiber assays, in vivo vascular phenotyping PNAS High 24958852
2015 Yoda1, a synthetic small molecule identified by screening ~3.25 million compounds, acts as a chemical agonist for both human and mouse Piezo1, affecting sensitivity and inactivation kinetics of mechanically induced responses. Yoda1 activates purified Piezo1 channels reconstituted in artificial droplet lipid bilayers in the absence of other cellular components, demonstrating direct channel activation. Cell-based fluorescence screening, electrophysiology, reconstitution of purified Piezo1 in droplet lipid bilayers eLife High 26001275
2015 Red blood cells exhibit Piezo1-dependent calcium entry in response to mechanical stretch. RBC-specific Piezo1 conditional knockout produces overhydrated, fragile RBCs. Piezo1 activation by Yoda1 causes calcium influx and subsequent RBC dehydration via downstream activation of the KCa3.1 Gardos channel, establishing the Piezo1→Gardos channel axis for RBC volume control. RBC-specific conditional knockout mice, calcium imaging, RBC fragility assays (in vitro and in vivo), Yoda1 pharmacology, Gardos channel pharmacological dissection eLife High 26001274
2017 Mechanical stretch stimulates epithelial cell division through Piezo1. Stretch triggers cells paused in early G2 to activate calcium-dependent phosphorylation of ERK1/2, activating cyclin B transcription to drive mitosis. Piezo1 subcellular localization differs with cell density: in sparse (dividing) regions it localizes to the plasma membrane and cytoplasm, while in dense (extruding) regions it forms large cytoplasmic aggregates. Mechanical stretch of epithelia, calcium imaging, phospho-ERK assays, cyclin B reporter assays, Piezo1 knockdown, live-cell imaging of Piezo1 localization Nature High 28199303
2019 Dietary fatty acids tune Piezo1 mechanical response: margaric acid (a saturated fatty acid) inhibits Piezo1 activation by increasing membrane bending stiffness, whereas polyunsaturated fatty acids (PUFAs) modulate channel inactivation by decreasing membrane bending stiffness. Fatty acid supplementation can abrogate gain-of-function Piezo1 mutation phenotypes. Lipid profiling, electrophysiology, atomic force microscopy membrane stiffness measurements, fatty acid supplementation in gain-of-function Piezo1 mutant cells Nature Communications High 30867417
2019 Piezo1 is required for bone formation by osteoblasts: knockout of Piezo1 in osteoblast lineage cells disrupts osteogenesis and impairs bone structure and strength, and simulated microgravity suppresses Piezo1 expression in osteoblasts to reduce their function. Osteoblast-lineage-specific conditional knockout mice, bone histology and biomechanical testing, microgravity simulation, gene expression analysis eLife High 31290742
2019 Piezo1 mediates fluid shear stress-induced gene expression changes in osteocytes, and conditional deletion of Piezo1 in osteoblasts and osteocytes reduces bone mass and strength. Administration of a Piezo1 agonist (Yoda1) to adult mice increases bone mass, mimicking mechanical loading. Fluid shear stress assays in cultured osteocytes, conditional knockout mice, in vivo Yoda1 administration, bone mass and strength measurements eLife High 31588901
2019 Piezo1 activation leads to ATP release from cells, which acts as an autocrine/paracrine signal activating P2 purinergic receptors to regulate cell functions. Piezo1-mediated mechanotransduction thus couples mechanical stimulation to downstream purinergic signaling. ATP release assays, P2 receptor pharmacology, Piezo1 knockdown/activation experiments across multiple cell types Frontiers in Pharmacology Medium 31780935
2020 Piezo1 in mature adipocytes mediates diet-induced adipogenesis by releasing adipogenic fibroblast growth factor 1 (FGF1) upon channel opening, which induces adipocyte precursor differentiation through activation of FGF receptor 1. Mice lacking Piezo1 in mature adipocytes show defective preadipocyte differentiation on high-fat diet. Mature adipocyte-specific conditional Piezo1 knockout mice, high-fat diet challenge, FGF1 measurement, FGFR1 pharmacological inhibition, adipogenesis assays Nature Communications High 32385276
2020 Gut Piezo1 in enterochromaffin cells functions as a sensor for single-stranded RNA (ssRNA) from fecal microbiota, governing serotonin (5-HT) production. Intestinal epithelium-specific Piezo1 deletion profoundly disturbs gut peristalsis and suppresses serum 5-HT levels. Colonic infusion of RNase A suppressed gut motility and increased bone mass, confirming the ssRNA–Piezo1 axis. Intestinal epithelium-specific conditional Piezo1 knockout, fecal ssRNA identification as ligand, RNase A infusion experiments, calcium imaging, bone mass measurement Cell High 32640190
2021 Piezo1 is a key regulator of macrophage phagocytic activity and erythrocyte turnover, controlling hepcidin levels and iron metabolism. Constitutive or macrophage-specific expression of a gain-of-function Piezo1 allele in mice causes iron overload, and the E756del allele (present in ~1/3 of individuals of African descent) is strongly associated with increased plasma iron. Constitutive and macrophage-specific conditional knock-in of GOF Piezo1 allele in mice, hepcidin measurement, erythrocyte turnover assays, human genetic association in African Americans Cell High 33571427
2022 Cryo-EM of PIEZO1 reconstituted in liposome vesicles revealed curved (resting) and flattened (activated) structural states. Membrane tension induces flattening of the blade (~300 nm2 in-plane area expansion), bending of the beam, and detaching/rotating of the cap, collectively gating the ion-conducting pathway. The calculated half-maximal activation tension (~1.9 pN/nm) matches experimental values. Cryo-EM structural determination of Piezo1 in liposomes, in-plane area and stiffness calculations, comparison with detergent-solubilized structures Nature High 35388220
2022 Lipid peroxidation during ferroptosis increases plasma membrane tension, activating Piezo1 and TRP channels, causing cation permeability (Na+/Ca2+ influx, K+ efflux). Piezo1 deletion reduces these cation permeability changes. Oxidized lipids also depress Na+/K+-ATPase activity, and preventing cation content changes attenuates ferroptosis. Piezo1 deletion, calcium/sodium/potassium flux measurements, ruthenium red/2-APB channel blockers, ferroptosis induction (GPX4 inhibition), membrane tension measurement Current Biology High 36898371
2022 Astrocytic Piezo1 mediates mechanically evoked Ca2+ responses and ATP release (mechano-chemo transduction). Piezo1 deletion in astrocytes severely impairs adult hippocampal neurogenesis and abolishes ATP-dependent potentiation of neural stem cell proliferation. Overexpression of Piezo1 in astrocytes enhances LTP and learning/memory performance. Astrocyte-specific conditional knockout, in vivo neurogenesis assays, hippocampal LTP recordings, behavioral tests, ATP release measurement, Piezo1 overexpression Neuron High 35963237
2022 PECAM1 interacts with PIEZO1 and directs it to endothelial cell-cell junctions. PECAM1 extracellular N-terminus is critical for this interaction; CDH5 also drives PIEZO1 to junctions but its interaction is dynamic and increases with shear stress. PIEZO1 does not interact with VEGFR2. PIEZO1 is required for Ca2+-dependent formation of adherens junctions and associated cytoskeleton. Non-disruptive tagging of native PIEZO1 in mice, reconstitution experiments, high-resolution co-localization microscopy, co-immunoprecipitation, shear stress experiments, adherens junction assays Communications Biology High 37005489
2022 Endothelial PIEZO1 mediates leukocyte diapedesis: leukocyte-induced clustering of ICAM-1 synergizes with fluid shear stress to increase endothelial membrane tension and activate PIEZO1, elevating [Ca2+]i and driving phosphorylation of SRC, PYK2, and myosin light chain, opening the endothelial barrier. Endothelium-specific Piezo1 deficiency reduces leukocyte extravasation in vivo. Endothelial-specific conditional knockout mice, Ca2+ imaging, phospho-SRC/PYK2/MLC measurements, in vivo inflammation models, ICAM-1 clustering assays Blood High 35443048
2022 Piezo1 activation by matrix stiffness in macrophages promotes M1 polarization via the YAP signaling axis. Increased matrix stiffness upregulates Piezo1 expression and activates YAP, favoring M1 and suppressing M2 polarization. YAP inhibitor treatment re-polarizes macrophages to M2. Polyacrylamide gels of varying stiffness, Piezo1 expression analysis, YAP activation assays, pharmacological YAP inhibition, macrophage polarization markers, in vivo implant model Cell Proliferation Medium 38556840
2022 Piezo1 activation in renal proximal tubular cells by mechanical stretch, compression, or matrix stiffness causes calcium influx, activates calpain2, cleaves talin1, and upregulates integrin β1, driving profibrotic responses. TGF-β1 also upregulates Piezo1 expression to drive profibrotic changes via this pathway. HK2 cells and primary mouse proximal tubular cells under mechanical stimulation, Yoda1 pharmacology, Piezo1 siRNA/inhibitor, calpain2 activity assay, talin1 cleavage by western blot, integrin β1 assay, UUO/folic acid mouse models with GsMTx4 treatment JCI Insight High 35230979
2022 Piezo1 activation promotes Yap/Taz nuclear localization in periosteal stem cells, which in turn increases β-catenin nuclear localization. YAP directly interacts with β-catenin in the nucleus forming a transcriptional YAP/β-catenin complex that upregulates osteogenic, chondrogenic, and angiogenic factors including VEGF-A. Piezo1 agonist Yoda1 treatment of periosteal stem cells, YAP nuclear localization imaging, co-immunoprecipitation of YAP and β-catenin, gene expression assays, conditional knockout mice, fracture healing mouse model International Journal of Biological Sciences Medium 35844802
2023 Direct nanoscopic fluorescence imaging of PIEZO1 in living cells revealed that blades are significantly expanded at rest by plasma membrane bending stress, more so than predicted from detergent-solubilized structures. Blade expansion correlates with channel activation, and blade flexibility varies along its length due to decreased inter-subdomain binding strength. Single-molecule nanoscopic fluorescence imaging (dSTORM/PAINT) of endogenously tagged PIEZO1 in live cells, chemical and mechanical modulators of channel activity Nature High 37587339
2023 Piezo1 provides the mechanistic link between mechanical signals and EGFR-ERK activation. Piezo1 activation triggers clathrin-mediated EGFR endocytosis and ERK activation via Src-p38 kinase-dependent serine phosphorylation of EGFR (not canonical EGF-induced tyrosine autophosphorylation). This Piezo1-dependent pathway promotes nuclear ERK, AP-1 (FOS/JUN), and YAP accumulation. Piezo1 agonist/antagonist pharmacology, EGFR endocytosis assays, phosphorylation site analysis (serine vs tyrosine), Src and p38 inhibitors, nuclear ERK/AP-1/YAP imaging, ex vivo lung slice experiments Science Advances Medium 37756411
2023 Membrane stretch (detected by AFM with FEM modeling) is the mechanism of PIEZO1 gating in chondrocytes. PIEZO1 drives Ca2+ signaling independently at the highest strains, and factors increasing apparent membrane tension (hypoosmotic prestrain, high compression, low deformation rates) increase PIEZO1-driven Ca2+ signaling. The threshold membrane stretch ratio for PIEZO1 activation is λ=1.9. Single-cell AFM compression, finite element modeling, calcium imaging, PIEZO1/2 knockout chondrocytes, hypoosmotic treatment, pharmacological channel blockers PNAS High 37459546
2023 PIEZO1 activation in lymphatic endothelial cells by fluid flow causes rapid exocytosis of ANGPT2, ectodomain shedding of TIE1 by ADAM17, and increased TIE/PI3K/AKT signaling, followed by nuclear export of the transcription factor FOXO1, establishing a functional molecular network linking PIEZO1 mechanosensing to transcriptional regulation in lymphatic vessels. Piezo1 activation/inhibition in cultured LECs, ANGPT2 exocytosis assays, TIE1 shedding assays (ADAM17 involvement), PI3K/AKT/FOXO1 signaling analysis, conditional knockout mice Journal of Clinical Investigation High 38747287
2023 Piezo1 activation in neutrophils during trans-endothelial migration generates spike-like Ca2+ signals, upregulates NADPH oxidase 4 (NOX4), and enhances bactericidal function. PMN-specific Piezo1 deletion impairs bacterial clearance in vivo. Mechanical forces in microfluidic systems recapitulate Piezo1-dependent NOX4 upregulation and bactericidal activation. Piezo1-specific conditional knockout in PMNs, intravital imaging, calcium imaging, microfluidic systems, NOX4 expression assays, in vivo bacterial infection models, adoptive transfer experiments Immunity High 38091995
2023 Piezo1 channels in brain capillary endothelial cells function as mechanosensors: activation by mechanical forces evokes Ca2+ signals in capillary endothelial cells, and these currents are absent upon endothelial cell-specific Piezo1 deletion. Electrophysiology of brain cortical and retinal capillaries, endothelial-specific Piezo1 deletion, genetically encoded Ca2+ indicator mice, ex vivo pressurized retina preparation Circulation Research High 35382561
2023 Piezo1 activation increases intracellular Ca2+ in shear-stressed neutrophils, mediating calpain activity and cytoskeleton remodeling, which consequently induces NETosis. Shear-stress-induced NETosis is dependent on Piezo1 expression and is enhanced by NETosis-inducing agents. Microfluidics shear stress application, Piezo1 knockdown/overexpression, calcium imaging, calpain activity assays, cytoskeleton imaging, NET quantification Nature Communications Medium 39174529
2023 Piezo1 in gastric X/A-like cells senses gastric distention and inhibits ghrelin production through the CaMKKII/CaMKIV-mTOR signaling pathway. X/A-like cell-specific Piezo1 knockout causes hyperghrelinemia, hyperphagia, and susceptibility to overweight; Piezo1 activation by Yoda1 or gastric bead implantation inhibits ghrelin production and decreases food intake. X/A-like cell-specific conditional Piezo1 knockout, Yoda1 pharmacology, gastric bead implantation, ghrelin measurements, CaMKKII/CaMKIV/mTOR pathway analysis in mHypoE-42 cell line Nature Metabolism High 38467889
2024 PIEZO1 activation in red blood cells triggers Ca2+ influx through PIEZO1, which activates TMEM16F (the long-sought-after RBC phosphatidylserine scramblase). PIEZO1-TMEM16F functional coupling is enhanced in hereditary xerocytosis RBCs with PIEZO1 gain-of-function mutations, leading to increased PS exposure. GsMTx-4 and benzbromarone inhibit PIEZO1 and prevent force-induced PS exposure and hemolysis. Calcium influx assays, PS exposure assays, TMEM16F functional coupling in normal and HX patient RBCs, pharmacological inhibition with GsMTx-4 and benzbromarone, echinocytosis/hemolysis assays Blood High 38033286
2024 PIEZO1 in cytotoxic T cells upregulates the transcription factor GRHL3, which induces expression of the E3 ubiquitin ligase RNF114. RNF114 binds to filamentous actin causing its downregulation and rearrangement, depressing traction forces in T cells. Blocking PIEZO1 strengthens traction forces and augments cytotoxicity against tumor cells. PIEZO1 knockout/antagonist treatment of cytotoxic T cells, traction force microscopy, GRHL3/RNF114 expression analysis, F-actin imaging, tumor killing assays, in vivo tumor model with adoptive T cell transfer Nature Biomedical Engineering High 38514773
2024 Macrophage Piezo1 promotes progression of liver fibrosis by activating the Ca2+-dependent calpain protease, which drives CTSS (cathepsin S) secretion via cleavage of lysosome-associated membrane protein-1 (LAMP1). Myeloid-specific Piezo1 knockout reduces macrophage inflammation, CTSS secretion, and liver fibrosis. Myeloid-specific conditional Piezo1 knockout mice, RNA-seq, CTSS activity assays, calpain inhibition, LAMP1 cleavage western blot, liver fibrosis models (CCl4/BDL) Theranostics Medium 37908726
2024 Piezo1 in ILC2s restrains group 2 innate lymphoid cell-driven type 2 lung inflammation. Yoda1 inhibits ILC2 cytokine secretion and proliferation in a KLF2-dependent manner by reducing ILC2 oxidative metabolism. Genetic ablation of Piezo1 in ILC2s exacerbates airway hyperreactivity. ILC2-specific conditional Piezo1 knockout mice, Yoda1 pharmacology, cytokine secretion assays, proliferation assays, KLF2 knockdown, metabolic assays (oxidative phosphorylation), in vivo AHR models, humanized mouse models Journal of Experimental Medicine High 38530239
2024 Disturbed flow activates Piezo1 in endothelial cells, causing Ca2+ influx that activates the CaM/CaMKII pathway, which phosphorylates FAK and Src, activating YAP and triggering endothelial inflammation. GsMTx4 inhibition of Piezo1 delays atherosclerotic plaque progression. Oscillatory shear stress application, Ca2+ imaging, pharmacological inhibition (GsMTx4, CaMKII inhibitor), FAK/Src/YAP phosphorylation assays, ApoE-/- atherosclerosis mouse model Journal of the American Heart Association Medium 39450718
2024 Macrophage Piezo1 activation promotes efferocytosis on rigid substrates and facilitates efficient acidification of engulfed cargo in phagolysosomes, driving anti-inflammatory gene expression after efferocytosis. Macrophage-specific Piezo1 knockout impairs efferocytosis and spontaneous resolution of early liver fibrosis. Macrophage-specific conditional Piezo1 knockout, polyacrylamide gel stiffness assays, phagolysosomal acidification assays, anti-inflammatory gene expression, in vivo liver fibrosis resolution model, Yoda1 pharmacology Science Advances Medium 38838160
2024 Piezo1 in podocytes triggers a signaling loop involving NFATc1 and TRPC6, leading to increased calcium influx and perpetuating podocyte injury in diabetic kidney disease. TRPC6 overexpression in podocyte-specific Piezo1 knockout mice counteracted the protective effects of Piezo1 deletion, confirming the Piezo1/NFATc1/TRPC6 axis. Podocyte-specific Piezo1 conditional knockout mice, DKD model (STZ+HFD), in vitro calcium influx assays, NFATc1 and TRPC6 expression analysis, AAV-mediated TRPC6 overexpression rescue experiment JASN Medium 39932793
2025 Piezo1 in pulmonary myofibroblasts (periostin+ cells) mediates mechanosensation essential for myofibroblast activation and lung fibrosis. Loss of Piezo1 in periostin+ cells disrupts actin organization and prevents Yap/Taz nuclear localization, shifting myofibroblasts from a proliferative to an apoptotic state. Myofibroblast-specific Yap/Taz deletion fully recapitulates protective Piezo1-KO phenotypes. Postn-specific conditional Piezo1 knockout mice, actin organization imaging, Yap/Taz nuclear localization assays, myofibroblast-specific Yap/Taz knockout for epistasis, bleomycin pulmonary fibrosis model Journal of Clinical Investigation High 40454481
2025 PIEZO1 in vascular smooth muscle cells attenuates Marfan syndrome aortic aneurysm by inhibiting the TGF-β signaling pathway through promoting endocytosis and autophagy of TGF-β receptor 2 (TGFBR2) via Rab GTPase 3C. Smooth muscle cell-specific Piezo1 knockout exacerbates aneurysm and TGF-β pathway activation; Yoda1 activation reverses aneurysm development. VSMC-specific conditional Piezo1 knockout in MFS mice, TGFBR2 endocytosis and autophagy assays, Rab3C involvement, Yoda1 pharmacological treatment in vivo, TGF-β pathway signaling assays European Heart Journal Medium 39585648
2025 Piezo1 in cardiomyocytes is elevated in diabetic cardiomyopathy and promotes mitochondrial fission via calpain activation and Drp1 dephosphorylation. Cardiac-specific Piezo1 knockout restores ERK1/2-mediated Drp1 phosphorylation (inhibitory), preserves mitochondrial dynamics, and ameliorates diabetic cardiac dysfunction and fibrosis. Cardiac-specific conditional Piezo1 knockout mice (STZ and HFD+STZ models), echocardiography, calpain activity assays, Drp1/ERK phosphorylation western blots, mitochondrial morphology and respiration assays, H9C2 cells and neonatal cardiomyocytes Cardiovascular Diabetology Medium 40114130
2022 Piezo1 activation stimulates mitochondrial calcium uptake and oxidative phosphorylation (OXPHOS). Loss of Piezo1 reduces mitochondrial oxygen consumption rate and ATP production in calvarial cells, associated with increased phosphodiesterase Pde4a expression and lower cAMP levels. cAMP signaling via PKA is required for the Piezo1-induced increase in mitochondrial OXPHOS. Piezo1 conditional knockout and agonist treatment in calvarial cells, Seahorse OCR measurements, cAMP reporter assays, phosphodiesterase inhibition, PKA inhibition, mitochondrial calcium imaging FASEB Journal Medium 36052712
2022 Piezo1 in lymphatic endothelial cells acts as the upstream mechanosensor for flow-induced Orai1-KLF2-Notch lymphatic mechanotransduction pathway. Piezo1 knockdown blocks laminar flow-induced calcium influx and Orai1 downstream gene regulation; Piezo1 stimulation activates Orai1 signaling without fluid flow; Orai1 inhibition blocks Piezo1-mediated mechanotransduction, establishing Piezo1 epistatic to Orai1. Lymphatic endothelial cell Piezo1 knockdown, flow-induced calcium imaging, lymphatic-specific conditional Piezo1 knockout mice, Orai1 inhibition for epistasis, in vivo lymphatic regeneration model, Yoda1 pharmacology for lymphedema treatment Circulation Research High 35701867

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science (New York, N.Y.) 2442 20813920
2014 Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proceedings of the National Academy of Sciences of the United States of America 712 24958852
2017 Mechanical stretch triggers rapid epithelial cell division through Piezo1. Nature 590 28199303
2015 Chemical activation of the mechanotransduction channel Piezo1. eLife 575 26001275
2015 Piezo1 links mechanical forces to red blood cell volume. eLife 501 26001274
2011 The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry 442 21696149
2012 Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood 363 22529292
2019 The mechanosensitive Piezo1 channel is required for bone formation. eLife 322 31290742
2019 Stimulation of Piezo1 by mechanical signals promotes bone anabolism. eLife 297 31588901
2019 Dietary fatty acids fine-tune Piezo1 mechanical response. Nature communications 214 30867417
2022 Structure deformation and curvature sensing of PIEZO1 in lipid membranes. Nature 213 35388220
2023 Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis. Current biology : CB 198 36898371
2021 A role of PIEZO1 in iron metabolism in mice and humans. Cell 184 33571427
2010 Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum. Journal of cell science 177 20016066
2021 Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues. Bone research 167 34667178
2022 Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation. Frontiers in immunology 146 35154133
2021 Mechanosensing by Piezo1 and its implications for physiology and various pathologies. Biological reviews of the Cambridge Philosophical Society 146 34781417
2012 Loss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migration. PloS one 137 22792288
2022 Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions. Neuron 133 35963237
2022 Mechanosensitive Piezo1 channels mediate renal fibrosis. JCI insight 132 35230979
2020 RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis. Cell 132 32640190
2022 Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma. Cancer communications (London, England) 131 36181398
2020 Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nature communications 126 32385276
2023 The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation. Proceedings of the National Academy of Sciences of the United States of America 124 37098060
2019 Expression and distribution of PIEZO1 in the mouse urinary tract. American journal of physiology. Renal physiology 116 31166705
2023 Direct observation of the conformational states of PIEZO1. Nature 113 37587339
2022 Microglial amyloid beta clearance is driven by PIEZO1 channels. Journal of neuroinflammation 109 35706029
2017 Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction. Current topics in membranes 108 28728825
2022 Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries. Circulation research 105 35382561
2021 Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension. American journal of physiology. Cell physiology 95 34669509
2024 Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the resolution of liver fibrosis. Science advances 93 38838160
2022 Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood 87 35443048
2022 Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion. Circulation research 79 35701867
2022 Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing. International journal of biological sciences 79 35844802
2023 PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing. Communications biology 78 37005489
2022 Myeloid Piezo1 Deletion Protects Renal Fibrosis by Restraining Macrophage Infiltration and Activation. Hypertension (Dallas, Tex. : 1979) 77 35417225
2021 Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception. JCI insight 70 34464353
2024 Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development. Bone research 68 38395992
2023 Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin. Journal of advanced research 67 37758057
2024 Matrix stiffness regulates macrophage polarisation via the Piezo1-YAP signalling axis. Cell proliferation 65 38556840
2022 Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target. International journal of biological sciences 64 35173527
2023 trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing. Immunity 62 38091995
2017 Piezo1 Channels in Vascular Development and the Sensing of Shear Stress. Current topics in membranes 62 28728823
2022 Keratinocyte PIEZO1 modulates cutaneous mechanosensation. eLife 61 36053009
2023 Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes. Proceedings of the National Academy of Sciences of the United States of America 59 37459546
2024 Mechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop. Cell death & disease 58 38267432
2024 PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes. Nature biomedical engineering 54 38514773
2023 Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice. Theranostics 54 37908726
2023 Matrine induces ferroptosis in cervical cancer through activation of piezo1 channel. Phytomedicine : international journal of phytotherapy and phytopharmacology 54 37922791
2019 Adenosine Triphosphate Release and P2 Receptor Signaling in Piezo1 Channel-Dependent Mechanoregulation. Frontiers in pharmacology 54 31780935
2022 PIEZO1 mediates a mechanothrombotic pathway in diabetes. Science translational medicine 53 34985971
2024 Piezo1 expression in neutrophils regulates shear-induced NETosis. Nature communications 50 39174529
2023 Lepr-Expressing PDLSCs Contribute to Periodontal Homeostasis and Respond to Mechanical Force by Piezo1. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 50 37553778
2024 Piezo1-Mediated Mechanotransduction Contributes to Disturbed Flow-Induced Atherosclerotic Endothelial Inflammation. Journal of the American Heart Association 44 39450718
2022 Piezo1-mediated mechanotransduction promotes entheseal pathological new bone formation in ankylosing spondylitis. Annals of the rheumatic diseases 44 36543525
2021 Recent advances in the pathophysiology of PIEZO1-related hereditary xerocytosis. American journal of hematology 38 33848364
2024 Dexamethasone upregulates macrophage PIEZO1 via SGK1, suppressing inflammation and increasing ROS and apoptosis. Biochemical pharmacology 35 38354960
2023 Piezo1 suppression reduces demyelination after intracerebral hemorrhage. Neural regeneration research 35 36751801
2024 Quercetin ameliorates atherosclerosis by inhibiting inflammation of vascular endothelial cells via Piezo1 channels. Phytomedicine : international journal of phytotherapy and phytopharmacology 33 39004029
2024 Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis. Blood 30 38033286
2024 Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity. The Journal of experimental medicine 30 38530239
2022 The role of mechanosensor Piezo1 in bone homeostasis and mechanobiology. Developmental biology 30 36368521
2024 Ion channel Piezo1 activation aggravates the endothelial dysfunction under a high glucose environment. Cardiovascular diabetology 29 38702777
2023 Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress. Liver international : official journal of the International Association for the Study of the Liver 29 37349903
2019 Amphipathic molecules modulate PIEZO1 activity. Biochemical Society transactions 29 31754715
2024 The chondrocyte "mechanome": Activation of the mechanosensitive ion channels TRPV4 and PIEZO1 drives unique transcriptional signatures. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 38959010
2024 Pharmacology of PIEZO1 channels. British journal of pharmacology 28 39402010
2023 Actomyosin Activity and Piezo1 Activity Synergistically Drive Urinary System Fibroblast Activation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 27 37867255
2021 Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis. Journal of inflammation research 27 34349540
2025 PIEZO1-Mediated Calcium Signaling and Podocyte Injury in Diabetic Kidney Disease. Journal of the American Society of Nephrology : JASN 25 39932793
2025 PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice. The Journal of clinical investigation 25 40454481
2024 Long-term simulated microgravity fosters carotid aging-like changes via Piezo1. Cardiovascular research 25 38271270
2024 Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake. Nature metabolism 25 38467889
2024 Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis. Free radical biology & medicine 25 39216559
2023 Piezo1 Mediates Vasodilation Induced by Acute Hyperglycemia in Mouse Renal Arteries and Microvessels. Hypertension (Dallas, Tex. : 1979) 25 37259842
2022 The role of mechanosensitive Piezo1 channel in diseases. Progress in biophysics and molecular biology 24 35436566
2024 Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca2+ influx. Journal of translational medicine 23 38575957
2024 The mechanosensory channel PIEZO1 functions upstream of angiopoietin/TIE/FOXO1 signaling in lymphatic development. The Journal of clinical investigation 23 38747287
2023 Piezo1 opposes age-associated cortical bone loss. Aging cell 23 37147884
2022 Piezo1 stimulates mitochondrial function via cAMP signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23 36052712
2023 Piezo1 activates noncanonical EGFR endocytosis and signaling. Science advances 22 37756411
2025 Elevated expression of Piezo1 activates the cGAS-STING pathway in chondrocytes by releasing mitochondrial DNA. Osteoarthritis and cartilage 21 39978573
2024 PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis. Cellular and molecular life sciences : CMLS 21 39107572
2025 Piezo1 in PASMCs: Critical for Hypoxia-Induced Pulmonary Hypertension Development. Circulation research 20 40181773
2024 Piezo1, the new actor in cell volume regulation. Pflugers Archiv : European journal of physiology 20 38581527
2021 Piezo1 plays a role in optic nerve head astrocyte reactivity. Experimental eye research 20 33465396
2025 Piezo1: structural pharmacology and mechanotransduction mechanisms. Trends in pharmacological sciences 19 40750459
2023 Piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion-induced TMJOA. Oral diseases 19 37184045
2023 Piezo1：the potential new therapeutic target for fibrotic diseases. Progress in biophysics and molecular biology 19 37722629
2025 PIEZO1 attenuates Marfan syndrome aneurysm development through TGF-β signaling pathway inhibition via TGFBR2. European heart journal 18 39585648
2025 Piezo1-directed neutrophil extracellular traps regulate macrophage differentiation during influenza virus infection. Cell death & disease 18 39890818
2025 Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway. Cardiovascular diabetology 18 40114130
2024 Mechanosensitive Cation Channel Piezo1 Is Involved in Renal Fibrosis Induction. International journal of molecular sciences 18 38338996
2023 Piezo1 facilitates optimal T cell activation during tumor challenge. Oncoimmunology 18 38126029
2023 Piezo1 in skin wound healing and related diseases: Mechanotransduction and therapeutic implications. International immunopharmacology 17 37582313
2022 Expression of Piezo1 in the Trigeminal Neurons and in the Axons That Innervate the Dental Pulp. Frontiers in cellular neuroscience 17 35846568
2025 Targeting Piezo1 channel to alleviate intervertebral disc degeneration. Journal of orthopaedic translation 16 40129609
2024 Role of mechanically-sensitive cation channels Piezo1 and TRPV4 in trabecular meshwork cell mechanotransduction. Human cell 16 38316716
2024 Piezo1 and Piezo2 collectively regulate jawbone development. Development (Cambridge, England) 16 38619396
2023 PIEZO1 expression at the glio-vascular unit adjusts to neuroinflammation in seizure conditions. Neurobiology of disease 16 37717661

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