Affinage

PFN1

Profilin-1 · UniProt P07737

Length
140 aa
Mass
15.1 kDa
Annotated
2026-06-10
51 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PFN1 (profilin-1) is a small actin-binding protein that drives cytoskeletal remodeling by engaging monomeric actin and polyproline-motif partners such as VASP and formins, thereby promoting actin polymerization and processes that depend on it including cell migration, neuromuscular junction remodeling, and osteoclast actin-ring formation (PMID:30814249, PMID:28379367, PMID:40458045). Its interaction with polyproline ligands is mediated through an alpha helix that simultaneously contacts actin and polyproline, and binding to VASP is gated by PKA-mediated phosphorylation at Ser137, which suppresses the interaction and contributes to the anti-migratory effects of cAMP/PKA signaling (PMID:34074767, PMID:30814249). PFN1 abundance is tightly controlled by multiple ubiquitin-dependent routes: FBXL4 directs K48-linked ubiquitination at K70 to drive proteasomal turnover and preserve sarcomeric integrity in cardiomyocytes, SH3BGRL accelerates PFN1 degradation via the E3 ligase STUB1, and TRIM37-mediated K116 ubiquitination converts PFN1 into a recognition motif for the cargo receptor SQSTM1/p62 to enable selective autophagy (PMID:41589689, PMID:34331014, PMID:42260986). ALS-linked mutations partition into distinct mechanisms: C71G is severely destabilized and aggregates, forming detergent-insoluble inclusions that seed pathology and sequester the chaperone DNAJB6, while M114T and G118V retain or augment formin-mediated actin assembly yet acquire toxic gains of function, including enhanced PI3P binding and dysregulation of autophagic and endo-lysosomal clearance (PMID:34074767, PMID:27681617, PMID:37817804, PMID:38509062, PMID:35628504). Loss-of-function PFN1 variants cause a Paget's-disease-like osteoclast phenotype, where PFN1 specifically governs actin-ring formation independent of NF-κB signaling (PMID:32392277, PMID:40458045).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2016 High

    Established that ALS-associated mutant PFN1 is causally pathogenic in vivo and that disease onset precedes aggregate accumulation, separating toxicity from inclusion formation.

    Evidence Transgenic mouse model expressing C71G vs wild-type PFN1 with histopathology and behavioral readouts

    PMID:27681617

    Open questions at the time
    • Does not define the molecular trigger of degeneration preceding aggregation
    • Limited to the C71G variant
  2. 2017 Medium

    Defined wild-type PFN1's positive role in actin-dependent neuromuscular junction remodeling and showed ALS mutants are partial loss-of-function in this process.

    Evidence Drosophila transgenic model with NMJ morphology, F-actin, and locomotion assays

    PMID:28379367

    Open questions at the time
    • Heterologous human-PFN1-in-fly system may not reflect mammalian neuron biology
    • Does not reconcile partial loss of function with gain-of-toxicity models
  3. 2019 High

    Identified PKA phosphorylation at Ser137 as a regulatory switch controlling the PFN1-VASP interaction and migration.

    Evidence Mutagenesis with knockdown-rescue, co-immunoprecipitation, and migration assays

    PMID:30814249

    Open questions at the time
    • Does not establish the kinase-substrate stoichiometry in vivo
    • Effect on formin binding not addressed
  4. 2020 Medium

    Resolved the temporal order of PFN1 pathology, showing detergent-insoluble inclusions are the earliest detectable event in mutant rats, and identified a loss-of-function osteoclast disease mechanism for truncating PFN1 variants.

    Evidence C71G transgenic rats with temporal detergent fractionation; whole-exome sequencing plus osteoclastogenesis and murine knockdown for D107Rfs*3

    PMID:32392277 PMID:32754913

    Open questions at the time
    • Aggregation-vs-onset ordering differs from the 2016 mouse study
    • Mechanism linking PFN1 loss to enhanced osteoclast actin-ring formation undefined
  5. 2021 High

    Distinguished the molecular fates of different ALS mutations, showing C71G is destabilized/loss-of-function while M114T and G118V retain altered formin binding and augmented actin assembly.

    Evidence Differential interactome proteomics, in vitro actin assembly, MD simulations, and cell-based expression

    PMID:34074767

    Open questions at the time
    • Does not connect augmented actin assembly to neuronal toxicity
    • In vitro assembly may not capture cellular regulation
  6. 2021 Medium

    Showed PFN1 levels are controlled by E3-ligase-dependent degradation, with SH3BGRL promoting STUB1-mediated turnover and loss of PFN1 activating pro-metastatic signaling.

    Evidence Co-IP, protein degradation and translation assays, in vitro/in vivo tumor models

    PMID:34331014

    Open questions at the time
    • Single lab; STUB1 ubiquitination site on PFN1 not mapped
    • Direct vs indirect ligase recruitment not fully resolved
  7. 2022 Medium

    Connected ALS mutant PFN1 to autophagy and mitochondrial quality control and identified additional regulators of PFN1 stability and signaling.

    Evidence Patient lymphoblasts/transgenic mice (M114T, RAB9 autophagy); lncRNA UCA1/USP14 Co-IP and ubiquitination (endothelial cells); Cdc42 Co-IP/MS signaling (satellite cells)

    PMID:35628504 PMID:36160709 PMID:36291059

    Open questions at the time
    • These mechanisms are each from single labs and different cell systems
    • Whether they converge on a shared PFN1 regulatory node is unknown
  8. 2023 Medium

    Demonstrated prion-like seeding of PFN1 pathology and identified chaperone DNAJB6 sequestration as a consequence of pathogenic PFN1.

    Evidence Intramuscular seeding in transgenic rats plus DNAJB6 Co-IP

    PMID:37817804

    Open questions at the time
    • Does not establish whether DNAJB6 sequestration drives toxicity
    • Seeding species/conformer not biochemically defined
  9. 2024 High

    Defined a gain-of-toxic-function for ALS mutant PFN1 in non-neuronal cells, with enhanced PI3P binding driving autophagy and phagocytosis defects rescuable by rapamycin.

    Evidence iPSC-derived microglia with phagocytosis, PI3P binding, lipidomics, and rapamycin rescue

    PMID:38509062

    Open questions at the time
    • Mechanistic link between PI3P binding and lipid dysmetabolism not fully resolved
    • Relevance to motor neuron death not directly tested
  10. 2026 Medium

    Mapped two site-specific ubiquitination events controlling PFN1 fate: FBXL4-driven K48 ubiquitination at K70 for proteasomal turnover, and TRIM37-driven K116 ubiquitination targeting PFN1 to p62-mediated selective autophagy during viral restriction.

    Evidence Co-IP, ubiquitination site mapping, AAV in mouse hearts and hiPSC-cardiomyocytes (FBXL4/K70); KSHV replication and autophagy assays (TRIM37/K116)

    PMID:41589689 PMID:42260986

    Open questions at the time
    • How K70 vs K116 ubiquitination is selected in different contexts is unclear
    • TRIM37/K116 mechanism is single-lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PFN1's normal actin-regulatory activity, its multiple competing degradation routes, and the divergent loss- vs gain-of-function consequences of ALS mutations are mechanistically integrated within a single neuron remains unresolved.
  • No unified model reconciling partial loss of actin function with autophagic gain-of-toxicity
  • Tissue-specific selection among FBXL4, STUB1, and TRIM37 degradation pathways undefined
  • Structural basis of mutation-specific PI3P binding not determined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 2 GO:0008289 lipid binding 1
Localization
GO:0005856 cytoskeleton 2 GO:0005829 cytosol 1
Pathway
R-HSA-392499 Metabolism of proteins 3 R-HSA-9612973 Autophagy 3
Partners
CDC42DNAJB6FBXL4SQSTM1STUB1TRIM37USP14VASP

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2021 ALS-linked PFN1 variants G118V and M114T show differential binding to select formin proteins compared to wild-type PFN1, and both variants augment formin-mediated actin assembly relative to WT PFN1. Molecular dynamics simulations revealed mutation-induced changes in internal dynamic couplings within an alpha helix of PFN1 that directly contacts both actin and polyproline. In contrast, C71G is more severely destabilized, resulting in reduced protein expression and loss-of-function in actin assembly. Unbiased proteomics (differential interactome), in vitro actin assembly assays, molecular dynamics simulations, cell-based expression assays Proceedings of the National Academy of Sciences of the United States of America High 34074767
2016 Transgenic mice expressing ALS-associated mutant PFN1 (C71G), but not wild-type PFN1, develop progressive motor neuron loss, muscle weakness, and paralysis. Mutant PFN1 forms insoluble aggregates, disrupts cytoskeletal structure, and elevates ubiquitin and p62/SQSTM1 levels in motor neurons. Acceleration of motor neuron degeneration precedes accumulation of mutant PFN1 aggregates, indicating aggregation is not the trigger of disease onset. Transgenic mouse model (gain-of-function), histopathology, immunostaining, behavioral testing Proceedings of the National Academy of Sciences of the United States of America High 27681617
2019 PFN1 interaction with VASP is promoted by cell-substrate adhesion and requires downregulation of PKA activity. PKA-mediated phosphorylation of PFN1 at Ser137 negatively regulates the PFN1-VASP interaction and contributes to anti-migratory effects of cAMP/PKA agonists. Mutagenesis in overexpression and knockdown-rescue settings, co-immunoprecipitation, cell migration assays The Journal of biological chemistry High 30814249
2024 ALS-linked mutant PFN1 (G118V, M114T, C71G) expressed in iPSC-derived microglia causes lipid dysmetabolism, autophagy dysregulation, and deficient phagocytosis. Mutant PFN1 exhibits enhanced binding affinity for PI3P (a signaling molecule in autophagic/endocytic processing). Rapamycin rescued phagocytic dysfunction, implicating a gain-of-toxic function in autophagic and endo-lysosomal pathways. iPSC-derived microglia (iMGs), phagocytosis assays, PI3P binding assays, rapamycin rescue experiments, lipidomics Nature communications High 38509062
2022 The lncRNA UCA1 physically binds USP14 (a deubiquitinating enzyme) and functions as a scaffold to recruit USP14 to PFN1, inhibiting ubiquitination-dependent degradation of PFN1 and prolonging its half-life, thereby activating the RhoA/ROCK pathway and inducing ROS production in endothelial cells. Coculture system, exosome extraction, co-immunoprecipitation, ubiquitination assays, ROS measurement Oxidative medicine and cellular longevity Medium 36160709
2021 SH3BGRL promotes degradation of PFN1 by accelerating translation of the E3 ubiquitin ligase STUB1 (via interaction with ribosomal proteins) and/or enhancing the interaction of PFN1 with STUB1, leading to proteasomal degradation of PFN1. Loss of PFN1 activates AKT, NF-kB, and WNT signaling pathways, while forced PFN1 expression neutralizes SH3BGRL-induced metastasis with PTEN upregulation and PI3K-AKT inactivation. Co-immunoprecipitation, protein degradation assays, ribosome interaction studies, in vitro and in vivo tumor models Oncogene Medium 34331014
2022 PFN1 mutation M114T destabilizes the protein and deregulates the RAB9-mediated alternative autophagy pathway involved in clearance of damaged mitochondria. Motor neurons expressing M114T mutant PFN1 show mitochondrial abnormalities in vivo. Patient lymphoblasts, transfected cell lines, lentiviral transgenic mice, autophagy pathway marker analysis, mitochondrial morphology assessment International journal of molecular sciences Medium 35628504
2017 In a Drosophila model, expression of wild-type human PFN1 in motor neurons increases ghost boutons, active zone density, F-actin content, and filopodia formation at larval NMJs. ALS-causative PFN1 mutants display less pronounced NMJ phenotypes, suggesting partial loss of function in promoting NMJ remodeling and actin polymerization. Drosophila transgenic model, NMJ morphology analysis, locomotion and lifespan assays Human molecular genetics Medium 28379367
2020 A frameshift mutation (D107Rfs*3) in PFN1 causing truncation of the C-terminal portion of the protein leads to a loss of function of profilin 1 activity. In vitro osteoclastogenesis from mutation carriers showed higher numbers of osteoclasts with PDB-like features, and PFN1 silencing in murine bone marrow-derived monocytes recapitulated the phenotype, suggesting enhanced osteoclast motility and actin ring formation. Whole exome sequencing, in vitro osteoclastogenesis from PBMCs, PFN1 silencing in murine bone marrow-derived monocytes The Journal of clinical endocrinology and metabolism Medium 32392277
2022 PFN1 inhibits myogenic differentiation of bovine skeletal muscle satellite cells via binding to Cdc42 (identified by co-immunoprecipitation and mass spectrometry). PFN1 activates Cdc42, which increases phosphorylation of PAK, which in turn activates JNK phosphorylation, and both PAK and JNK are inhibitors of myogenic differentiation. Immunoprecipitation combined with mass spectrometry, kinase phosphorylation assays, overexpression/knockdown experiments Cells Medium 36291059
2020 Detergent-insoluble PFN1 inclusions are the first detected pathology in otherwise asymptomatic transgenic rats expressing mutant human PFN1 (C71G), preceding motor neuron loss and muscle atrophy, suggesting protein aggregation is involved in the neurodegeneration. Human genomic DNA transgenic rats, detergent fractionation, histopathology, behavioral testing Journal of neurochemistry Medium 32754913
2023 Intramuscular administration of detergent-insoluble materials from paralyzed mutant PFN1 transgenic rats accelerated development of PFN1 inclusions and ALS-like phenotypes in asymptomatic recipient mutant PFN1 rats (seeding effect). Pathogenic PFN1 exhibited enhanced affinity for molecular chaperone DNAJB6, leading to sequestration of DNAJB6 within protein inclusions. Intrinsic seeding experiment in transgenic rats, detergent fractionation, co-immunoprecipitation for DNAJB6 interaction Frontiers in neuroscience Medium 37817804
2026 FBXL4 (an F-box protein) interacts with PFN1 and promotes K48-linked ubiquitination of PFN1 at lysine 70, leading to its proteasomal degradation and preservation of sarcomeric integrity in cardiomyocytes. Loss of FBXL4 leads to PFN1 accumulation and cardiac dysfunction. Co-immunoprecipitation, ubiquitination site mapping (K70), AAV-mediated knockdown/overexpression in mouse hearts, hiPSC-derived cardiomyocytes Advanced science (Weinheim, Baden-Wurttemberg, Germany) High 41589689
2026 PFN1 interacts with KSHV helicase ORF44, and the E3 ubiquitin ligase TRIM37 facilitates polyubiquitination of PFN1 at lysine 116. This ubiquitinated PFN1 serves as a recognition motif for the cargo receptor SQSTM1/p62, leading to autophagic degradation of ORF44 and inhibition of KSHV lytic replication. Co-immunoprecipitation, ubiquitination site mapping (K116), autophagy-lysosomal degradation assays, KSHV replication assays Autophagy Medium 42260986
2025 A PFN1 L112P mutation in osteoclasts leads to enhanced actin ring-like structures at bone surfaces without affecting NF-κB activation, suggesting a specific role of PFN1 in actin ring formation during osteoclast function independent of NF-κB signaling. Heterozygous knock-in mouse model (Pfn1 L112P), osteoclast culture, immunofluorescence for actin rings, NF-κB activation assays The Journal of clinical endocrinology and metabolism Medium 40458045
2024 Oleic acid increases acetylation of PFN1 and promotes prostate cancer cell migration/invasion with enhanced PFN1 and FLNA localization to the leading edge. EPA decreases PFN1 acetylation and impedes lamellipodia/filopodia formation by reducing PFN1 localization to the leading edge. Global acetylome profiling, immunofluorescence, cell migration/invasion assays Proteomics Low 38430206
2019 Computational and simulation analysis of the PFN1–polyproline-10 binding interface confirmed that residues W3, H133, and S137 of PFN1 form favorable hydrogen bonds with polyproline-10, consistent with crystallographic binding structures and suggesting a zipping process during binding. Umbrella sampling (PMF), molecular dynamics simulations, steered molecular dynamics The Journal of chemical physics Low 30621420
2015 Nicotine induces PFN1 overexpression in mouse elongated spermatids via hypomethylation of the Pfn1 promoter, leading to increased actin polymerization and elevated sperm motility. 2D gel electrophoresis, mass spectrometry, bisulfite sequencing (promoter methylation), sperm motility analysis Andrology Low 26311342

Source papers

Stage 0 corpus · 51 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity. Proceedings of the National Academy of Sciences of the United States of America 89 27681617
2004 The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene. The Journal of experimental medicine 62 15365097
2013 PFN1 mutations are rare in Han Chinese populations with amyotrophic lateral sclerosis. Neurobiology of aging 54 23428184
2019 HLA-F-AS1/miR-330-3p/PFN1 axis promotes colorectal cancer progression. Life sciences 50 31863778
2021 ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization. Proceedings of the National Academy of Sciences of the United States of America 37 34074767
2013 Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients. Neurobiology of aging 34 23312802
2012 Screening of the PFN1 gene in sporadic amyotrophic lateral sclerosis and in frontotemporal dementia. Neurobiology of aging 34 23063648
2021 LncRNA HLA-F-AS1 promotes colorectal cancer metastasis by inducing PFN1 in colorectal cancer-derived extracellular vesicles and mediating macrophage polarization. Cancer gene therapy 33 33531647
2012 Mutation analysis of PFN1 in familial amyotrophic lateral sclerosis patients. Neurobiology of aging 32 23062600
2020 Knockdown of lncRNA HCP5 Suppresses the Progression of Colorectal Cancer by miR-299-3p/PFN1/AKT Axis. Cancer management and research 22 32606965
2012 Mutations in the PFN1 gene are not a common cause in patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration in France. Neurobiology of aging 22 23182804
2024 Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia. Nature communications 20 38509062
2015 Nicotine elevates sperm motility and induces Pfn1 promoter hypomethylation in mouse testis. Andrology 20 26311342
2022 Trophoblast Exosomal UCA1 Induces Endothelial Injury through the PFN1-RhoA/ROCK Pathway in Preeclampsia: A Human-Specific Adaptive Pathogenic Mechanism. Oxidative medicine and cellular longevity 19 36160709
2021 A novel lncRNA promotes myogenesis of bovine skeletal muscle satellite cells via PFN1-RhoA/Rac1. Journal of cellular and molecular medicine 19 33942976
2020 Mutation of PFN1 Gene in an Early Onset, Polyostotic Paget-like Disease. The Journal of clinical endocrinology and metabolism 19 32392277
2019 The VASP-profilin1 (Pfn1) interaction is critical for efficient cell migration and is regulated by cell-substrate adhesion in a PKA-dependent manner. The Journal of biological chemistry 19 30814249
2022 The Amyotrophic Lateral Sclerosis M114T PFN1 Mutation Deregulates Alternative Autophagy Pathways and Mitochondrial Homeostasis. International journal of molecular sciences 17 35628504
2013 Mutation analysis and immunopathological studies of PFN1 in familial and sporadic amyotrophic lateral sclerosis. Neurobiology of aging 17 23635659
2022 LncRNA PEG11as aggravates cerebral ischemia/reperfusion injury after ischemic stroke through miR-342-5p/PFN1 axis. Life sciences 15 36496032
2021 Adaptor SH3BGRL promotes breast cancer metastasis through PFN1 degradation by translational STUB1 upregulation. Oncogene 15 34331014
2022 PFN1 Prevents Psoriasis Pathogenesis through IκBζ Regulation. The Journal of investigative dermatology 14 35148999
2018 Changes in biophysical characteristics of PFN1 due to mutation causing amyotrophic lateral sclerosis. Metabolic brain disease 13 30203378
2019 In silico analysis of PFN1 related to amyotrophic lateral sclerosis. PloS one 11 31216283
2019 Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice. Frontiers in molecular neuroscience 10 31611772
2017 A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants. Human molecular genetics 10 28379367
2022 PFN1 Inhibits Myogenesis of Bovine Myoblast Cells via Cdc42-PAK/JNK. Cells 8 36291059
2019 PFN1 and integrin-β1/mTOR axis involvement in cornea differentiation of fibroblast limbal stem cells. Journal of cellular and molecular medicine 8 31513338
2020 Detergent-insoluble inclusion constitutes the first pathology in PFN1 transgenic rats. Journal of neurochemistry 7 32754913
2023 Long noncoding RNA RMRP ameliorates doxorubicin-induced apoptosis by interacting with PFN1 in a P53-Dependent manner. Molecular and cellular probes 6 37820747
2017 Association Study of Common Variants in PFN1 With Hypertension in a Han Chinese Population: A Case-Control Study and A Follow-up Study. American journal of hypertension 6 28541412
2024 Global acetylome profiling indicates EPA impedes but OA promotes prostate cancer motility through altered acetylation of PFN1 and FLNA. Proteomics 4 38430206
2023 Genetic Screening of ZNF687 and PFN1 in a Paget's Disease of Bone Cohort Indicates an Important Role for the Nuclear Localization Signal of ZNF687. Calcified tissue international 4 37728743
2019 Exploring the binding mechanism between human profilin (PFN1) and polyproline-10 through binding mode screening. The Journal of chemical physics 4 30621420
2014 PFN1 mutations are also rare in the Catalan population with amyotrophic lateral sclerosis. Journal of neurology 4 25249294
2024 Overexpression of miR-328-3p Inhibits Epithelial-Mesenchymal Transition in Prostate Cancer by Downregulating PFN1. Applied biochemistry and biotechnology 2 39715971
2022 Comparison between PFN1 and SOD1 mutations in amyotrophic lateral sclerosis. European journal of neurology 2 36176198
2025 Viral-mediated knockdown of Atxn2 attenuates TDP-43 pathology and muscle dysfunction in the PFN1C71G ALS mouse model. Acta neuropathologica communications 1 40413526
2025 A Missense Mutation in Close Proximity of ALS-linked PFN1 Mutations Causes Only Early-onset Paget Disease of Bone. The Journal of clinical endocrinology and metabolism 1 40458045
2025 MAIT Cells with High PFN1 Expression Mediate Immune Activation and Metabolic Reprogramming in Psoriasis. Clinical, cosmetic and investigational dermatology 1 40948612
2024 PFN1 Knockdown Aggravates Mitophagy to Retard Lung Adenocarcinoma Initiation and M2 Macrophage Polarization. Molecular biotechnology 1 39120820
2024 Circ_0000972 Inhibits Hepatocellular Carcinoma Cell Stemness by Targeting miR-96-5p/PFN1. Biochemical genetics 1 39621144
2023 Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia. bioRxiv : the preprint server for biology 1 37398081
2023 Association of PFN1 Gene Polymorphisms with Bone Mineral Density, Bone Turnover Markers, and Osteoporotic Fractures in Chinese Population. Calcified tissue international 1 37401976
2023 Osteolytic Bone Loss and Skeletal Deformities in a Mouse Model for Early-Onset Paget's Disease of Bone with PFN1 Mutation Are Treatable by Alendronate. Pharmaceuticals (Basel, Switzerland) 1 37895866
2021 PFN1 Gene Polymorphisms and the Bone Mineral Density Response to Alendronate Therapy in Postmenopausal Chinese Women with Low Bone Mass. Pharmacogenomics and personalized medicine 1 34992429
2026 F-Box and Leucine-Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48-Linked Ubiquitinated Degradation of Profilin-1 (PFN1). Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 41589689
2026 PFN1 inhibits lytic replication of Kaposi sarcoma-associated herpesvirus through SQSTM1/p62-mediated selective autophagy targeting the KSHV helicase. Autophagy 0 42260986
2025 Metal Ion Nanodepots Orchestrate Neuronal Axon and Dendrite Growth via the Actin-PFN1 Pathway. ACS applied materials & interfaces 0 40587522
2023 Novel variant c.92T > G (p.Val31Gly) in the PFN1 gene (ALS18) responsible for a specific phenotype in a large Bulgarian amyotrophic lateral sclerosis pedigree. Frontiers in neurology 0 36846111
2023 Detergent-insoluble PFN1 inoculation expedites disease onset and progression in PFN1 transgenic rats. Frontiers in neuroscience 0 37817804

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