Affinage

PDC

Phosducin · UniProt P20941

Length
246 aa
Mass
28.2 kDa
Annotated
2026-06-10
100 papers in source corpus 6 papers cited in narrative 6 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 4/4 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PDC (phosducin/MEKA) is a soluble acidic phosphoprotein expressed exclusively in retinal photoreceptors and pinealocytes, where it functions as a cytoplasmic modulator of G-protein signaling (PMID:2770450, PMID:2764917). Purified from the retinal soluble fraction, PDC co-elutes with the β- and γ-subunits of transducin as a ~74 kDa heterotrimer, establishing it as a direct binding partner of the Gβγ complex (PMID:2764917); the same association is observed for the immunologically identical 33-kDa phosphoprotein in pineal cytoplasm (PMID:2156830). PDC activity is controlled by β-adrenergic/cAMP signaling: it is phosphorylated on Ser73 by cAMP-dependent protein kinase (PKA), and in the pineal gland this phosphorylation, together with PDC abundance, rises at night during adrenergic stimulation and falls rapidly upon light exposure, with PDC synthesis itself driven by an adrenergic–cAMP mechanism (PMID:2156830, PMID:1659528). Developmentally, pineal PDC accumulation lags cytoplasmic Gβ — which appears before birth independently of PDC — and the two subsequently rise and fall in parallel, indicating tissue-specific, co-regulated expression of PDC with the cytoplasmic Gβγ pool (PMID:1511297).

Mechanistic history

Synthesis pass · year-by-year structured walk · 6 steps
  1. 1989 High

    Established that PDC/MEKA is a defined, photoreceptor-restricted soluble protein rather than a diffuse activity, fixing its cell-type identity and expression pattern.

    Evidence cDNA cloning, in situ hybridization, Western blot, and immunohistochemistry across bovine, chick, rat, and mouse retina

    PMID:2770450

    Open questions at the time
    • Did not define a molecular partner or biochemical function
    • Subcellular signaling role not addressed
  2. 1989 High

    Answered what PDC binds by showing it forms a stable cytoplasmic heterotrimer with the transducin Gβγ complex, placing it directly in the phototransduction G-protein cycle.

    Evidence Protein purification by gel permeation chromatography with SDS-PAGE identification of co-eluting transducin β and γ subunits

    PMID:2764917

    Open questions at the time
    • Functional consequence of Gβγ sequestration on transducin signaling not directly measured
    • Binding stoichiometry and affinity not quantified
  3. 1990 High

    Connected PDC to second-messenger signaling by demonstrating PKA phosphorylation downstream of β-adrenergic/cAMP stimulation and confirming the pineal 33PP is the same Gβγ-bound protein as retinal MEKA.

    Evidence 32Pi radiolabeling of intact pinealocytes, broken-cell PKA assay, 2D-PAGE, immunological analysis, and gel permeation fractionation

    PMID:2156830

    Open questions at the time
    • Effect of phosphorylation on Gβγ binding not resolved
    • Phosphorylation site not yet mapped
  4. 1991 High

    Mapped the regulatory phosphosite to Ser73 and showed PDC phosphorylation and abundance are under physiological light/dark and adrenergic control in vivo.

    Evidence In vivo pineal light/dark manipulation, organ culture with norepinephrine and (Bu)2cAMP, anti-phospho-MEKA antiserum, and protein-synthesis inhibition

    PMID:1659528

    Open questions at the time
    • Mechanistic link between Ser73 phosphorylation state and transducin modulation not established
    • Functional readout on photoreceptor/pineal signaling output absent
  5. 1990 Medium

    Characterized the human PDC gene as a single-copy locus highly conserved with bovine and expressed in both rod and cone photoreceptors, extending the model to human retina.

    Evidence Genomic DNA cloning and sequencing, Southern blot, and immunohistochemistry of human retina

    PMID:2383274

    Open questions at the time
    • No functional assay in human tissue
    • No disease association tested
  6. 1992 Medium

    Resolved the temporal relationship between PDC and its partner by showing cytoplasmic Gβ accumulates independently of PDC before birth, then co-regulates with PDC postnatally, indicating tissue-specific developmental control.

    Evidence Developmental immunoblotting of pineal and retinal tissue across postnatal time points with anti-MEKA and anti-Gβ antibodies

    PMID:1511297

    Open questions at the time
    • Causal regulator of tissue-specific PDC expression unknown
    • Functional consequence of co-regulation for signaling not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How Ser73 phosphorylation and Gβγ binding mechanistically modulate transducin-dependent phototransduction output remains unresolved in this corpus.
  • No functional assay links PDC binding to changes in G-protein signaling kinetics
  • Structural basis of the PDC–Gβγ interaction not determined
  • No loss-of-function/genetic phenotype reported

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 2 GO:0140313 molecular sequestering activity 1
Localization
GO:0005829 cytosol 3
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-9709957 Sensory Perception 2
Partners
GNB1GNGT1
Complex memberships
PDC–transducin Gβγ heterotrimer

Evidence

Reading pass · 6 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1989 MEKA protein (PDC) was identified as a retina-specific soluble protein expressed exclusively in photoreceptor cells, with mRNA accumulating in the inner segments; the protein has a molecular weight of ~32-33 kDa and is localized to photoreceptor cells in bovine, chick, rat, and mouse retinas. cDNA cloning, in situ hybridization, Western blot, immunohistochemistry with anti-MEKA antibody raised against E. coli-expressed fusion protein Brain research. Molecular brain research High 2770450
1989 Purified MEKA protein (PDC) from bovine retinal soluble fraction co-elutes with the β- and γ-subunits of transducin on gel permeation chromatography (~74 kDa complex), establishing that MEKA forms a cytoplasmic heterotrimer with the βγ-complex of transducin. Protein purification (gel permeation chromatography/Superose column), SDS-PAGE identification of co-eluting β- (36 kDa) and γ- (10 kDa) transducin subunits alongside MEKA (32 kDa) Biochemical and biophysical research communications High 2764917
1990 MEKA (PDC) is phosphorylated by cyclic AMP-dependent protein kinase (PKA) in pinealocytes in response to norepinephrine via a β-adrenergic–cAMP mechanism; this phosphorylation is rapid and sustained. The 33-kDa phosphoprotein (33PP) in pineal cytoplasm is immunologically identical to retinal MEKA and co-fractionates in a ~70 kDa complex with Gβγ in pineal cytoplasm. 32Pi radiolabeling of intact pinealocytes, broken-cell PKA phosphorylation assay, 2D-PAGE, immunological analysis with anti-MEKA antibody, gel permeation fractionation The Journal of biological chemistry High 2156830
1990 The human MEKA (PDC) gene encodes 246 amino acid residues (MW 28,311), is present as a single copy in the human genome, and its coding region shares 90.7% nucleotide and 88.5% amino acid homology with bovine MEKA cDNA. Anti-bovine MEKA antibody stains both rod and cone photoreceptor cells in human retina. Genomic DNA cloning and sequencing, Southern blot analysis, immunohistochemistry Biochemical and biophysical research communications Medium 2383274
1991 MEKA (PDC) is phosphorylated on Ser73 by cAMP-dependent protein kinase. In vivo, total MEKA and MEKA phosphorylation increase at night (during adrenergic stimulation of the pineal gland) and are rapidly reduced upon light exposure. Norepinephrine and (Bu)2cAMP increase total MEKA in a protein-synthesis-dependent manner, indicating MEKA synthesis is controlled by an adrenergic–cAMP mechanism. In vivo pineal gland studies with light/dark manipulation, organ culture with norepinephrine and (Bu)2cAMP, anti-phospho-MEKA antiserum (Anti-32), protein synthesis inhibition Endocrinology High 1659528
1992 During rat postnatal development, MEKA (PDC) is absent in the pineal gland before birth despite the presence of Gβ, indicating that cytoplasmic Gβ accumulation precedes and does not require MEKA. After postnatal day 7, pineal MEKA and cytoplasmic Gβ increase in parallel and both decrease after postnatal day 21, while retinal MEKA either increases or remains constant — demonstrating tissue-specific regulation of MEKA expression and its developmental co-regulation with cytoplasmic Gβγ. Developmental immunoblot analysis of pineal and retinal tissue across postnatal time points using anti-MEKA and anti-Gβ antibodies Brain research Medium 1511297

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer. Journal of the National Cancer Institute 314 29059435
2017 CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Immunity 282 28190711
1983 Primary structure of PDC-109, a major protein constituent of bovine seminal plasma. Biochemical and biophysical research communications 156 6870895
2007 HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha. Proceedings of the National Academy of Sciences of the United States of America 140 17956986
2020 Heterogeneous Escape from X Chromosome Inactivation Results in Sex Differences in Type I IFN Responses at the Single Human pDC Level. Cell reports 119 33296655
2019 What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity. Frontiers in immunology 114 31191558
2000 Mimicry peptides of human PDC-E2 163-176 peptide, the immunodominant T-cell epitope of primary biliary cirrhosis. Hepatology (Baltimore, Md.) 103 10827144
2004 Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans. Journal of clinical immunology 101 15622448
2020 Plasmacytoid Dendritic Cell (pDC) Infiltration Correlate with Tumor Infiltrating Lymphocytes, Cancer Immunity, and Better Survival in Triple Negative Breast Cancer (TNBC) More Strongly than Conventional Dendritic Cell (cDC). Cancers 96 33198125
2012 Spectrum of neurological and survival outcomes in pyruvate dehydrogenase complex (PDC) deficiency: lack of correlation with genotype. Molecular genetics and metabolism 84 23021068
2011 Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity. Journal of leukocyte biology 78 21551252
2023 pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells. Science immunology 77 36827419
2017 Expression of the CTLA-4 ligand CD86 on plasmacytoid dendritic cells (pDC) predicts risk of disease recurrence after treatment discontinuation in CML. Leukemia 76 28074067
2003 PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity. American journal of physiology. Renal physiology 76 14612380
1992 Refined solution structure and ligand-binding properties of PDC-109 domain b. A collagen-binding type II domain. Journal of molecular biology 73 1731074
2008 PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon. Proceedings of the National Academy of Sciences of the United States of America 72 18287072
1990 Pineal transduction. Adrenergic----cyclic AMP-dependent phosphorylation of cytoplasmic 33-kDa protein (MEKA) which binds beta gamma-complex of transducin. The Journal of biological chemistry 71 2156830
2008 CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis. Journal of autoimmunity 69 18644699
1997 Conformational features and thermal stability of bovine seminal plasma protein PDC-109 oligomers and phosphorylcholine-bound complexes. European journal of biochemistry 66 9461296
1995 Immunohistochemical analysis of adhesion molecules in the micro-environment of portal tracts in relation to aberrant expression of PDC-E2 and HLA-DR on the bile ducts in primary biliary cirrhosis. The Journal of pathology 65 7538164
2011 Primary human mDC1, mDC2, and pDC dendritic cells are differentially infected and activated by respiratory syncytial virus. PloS one 61 21297989
1995 Abnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary biliary cirrhosis. Hepatology (Baltimore, Md.) 60 7590661
2012 Tissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor. Blood 58 22547585
2001 Membrane insertion and lipid-protein interactions of bovine seminal plasma protein PDC-109 investigated by spin-label electron spin resonance spectroscopy. Biophysical journal 58 11566792
2004 Ly49Q defines 2 pDC subsets in mice. Blood 57 15598811
2006 Variations in plasmacytoid dendritic cell (PDC) and myeloid dendritic cell (MDC) levels in HIV-infected subjects on and off antiretroviral therapy. Journal of clinical immunology 56 16418803
1990 pdc1(0) mutants of Saccharomyces cerevisiae give evidence for an additional structural PDC gene: cloning of PDC5, a gene homologous to PDC1. Journal of bacteriology 55 2404950
2018 Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association. Seminars in cell & developmental biology 54 29444460
2012 The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes. Diabetes 54 22315317
2008 Chronic exposure to dietary sterol glucosides is neurotoxic to motor neurons and induces an ALS-PDC phenotype. Neuromolecular medicine 54 18196479
2005 Differential effects of the substrate inhibitor l-trans-pyrrolidine-2,4-dicarboxylate (PDC) and the non-substrate inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) of glutamate transporters on neuronal damage and extracellular amino acid levels in rat brain in vivo. Neuroscience 54 15890455
2020 Discovery of novel cell-penetrating and tumor-targeting peptide-drug conjugate (PDC) for programmable delivery of paclitaxel and cancer treatment. European journal of medicinal chemistry 53 33280896
2004 Low-level HIV infection of plasmacytoid dendritic cells: onset of cytopathic effects and cell death after PDC maturation. Virology 53 15518808
2011 Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription. Cellular signalling 51 21397011
1990 Site-directed mutagenesis of lysine within the immunodominant autoepitope of PDC-E2. Hepatology (Baltimore, Md.) 50 1701753
2023 Scutellarin Rescued Mitochondrial Damage through Ameliorating Mitochondrial Glucose Oxidation via the Pdk-Pdc Axis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 49 37750289
2017 Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal transduction and targeted therapy 49 29263907
2000 Fine specificity of T cells reactive to human PDC-E2 163-176 peptide, the immunodominant autoantigen in primary biliary cirrhosis: implications for molecular mimicry and cross-recognition among mitochondrial autoantigens. Hepatology (Baltimore, Md.) 49 11050037
1989 Isolation of a novel retina-specific clone (MEKA cDNA) encoding a photoreceptor soluble protein. Brain research. Molecular brain research 48 2770450
2013 Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo. PloS one 47 23741395
2006 Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia. Human molecular genetics 47 17185385
2010 The major protein of bovine seminal plasma, PDC-109, is a molecular chaperone. Biochemistry 46 20377251
2005 Plasmacytoid dendritic cells (PDC) are the major DC subset innately producing cytokines in human lymph nodes. Journal of leukocyte biology 46 16260587
1999 Biosynthetic burden and plasmid burden limit expression of chromosomally integrated heterologous genes (pdc, adhB) in Escherichia coli. Biotechnology progress 42 10514259
2016 Escherichia coli Nissle 1917 protects gnotobiotic pigs against human rotavirus by modulating pDC and NK-cell responses. European journal of immunology 39 27457183
2003 Decrease in glial glutamate transporter variants and excitatory amino acid receptor down-regulation in a murine model of ALS-PDC. Neuromolecular medicine 39 12728193
1985 The PDC-109 protein from bovine seminal plasma is similar to the gelatin-binding domain of bovine fibronectin and a kringle domain of human tissue-type plasminogen activator. Biochemical and biophysical research communications 39 4040757
2018 Intratumoral CpG-B Promotes Antitumoral Neutrophil, cDC, and T-cell Cooperation without Reprograming Tolerogenic pDC. Cancer research 38 29588348
2002 Cloning and characterization of the Zymobacter palmae pyruvate decarboxylase gene (pdc) and comparison to bacterial homologues. Applied and environmental microbiology 38 12039744
2014 Independent of plasmacytoid dendritic cell (pDC) infection, pDC triggered by virus-infected cells mount enhanced type I IFN responses of different composition as opposed to pDC stimulated with free virus. Journal of immunology (Baltimore, Md. : 1950) 37 25070849
2012 Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection. PLoS pathogens 37 23028315
2009 Impaired plasmacytoid dendritic cell (PDC)-NK cell activity in viremic human immunodeficiency virus infection attributable to impairments in both PDC and NK cell function. Journal of virology 36 19692459
2004 Sidechain biology and the immunogenicity of PDC-E2, the major autoantigen of primary biliary cirrhosis. Hepatology (Baltimore, Md.) 36 15558739
2003 The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Biochemistry 36 12962488
2019 Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus. International immunology 35 30534943
2002 In vivo temporal sequence of rat striatal glutamate, aspartate and dopamine efflux during apomorphine, nomifensine, NMDA and PDC in situ administration. Neuropharmacology 35 12384168
2017 HIV-1 infection depletes human CD34+CD38- hematopoietic progenitor cells via pDC-dependent mechanisms. PLoS pathogens 34 28759657
2004 Interaction of PDC-109, the major secretory protein from bull seminal vesicles, with bovine sperm membrane Ca2+-ATPase. Journal of andrology 34 14760009
2011 Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity. Journal of autoimmunity 33 21763105
1999 Characterisation of the conformational and quaternary structure-dependent heparin-binding region of bovine seminal plasma protein PDC-109. FEBS letters 33 10050771
2020 Western Pacific ALS-PDC: Evidence implicating cycad genotoxins. Journal of the neurological sciences 32 33190068
2015 Profiling of sperm proteins and association of sperm PDC-109 with bull fertility. Systems biology in reproductive medicine 32 26484773
2002 Influence of the bovine seminal plasma protein PDC-109 on cholesterol in the presence of phospholipids. European biophysics journal : EBJ 32 12355253
2021 Synthesis and application of [Zr-UiO-66-PDC-SO3H]Cl MOFs to the preparation of dicyanomethylene pyridines via chemical and electrochemical methods. Scientific reports 30 34413353
2019 Effect of in vivo Hydroxychloroquine and ex vivo Anti-BDCA2 mAb Treatment on pDC IFNα Production From Patients Affected With Cutaneous Lupus Erythematosus. Frontiers in immunology 30 30846987
2015 pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation. Journal of autoimmunity 30 26341385
2013 Epithelial control of the human pDC response to extracellular bacteria. European journal of immunology 30 23436642
2007 Functional expression, purification, and characterization of the recombinant Baeyer-Villiger monooxygenase MekA from Pseudomonas veronii MEK700. Applied microbiology and biotechnology 30 18034235
2002 Effect of cholesterol on the interaction of seminal plasma protein, PDC-109 with phosphatidylcholine membranes. FEBS letters 30 12297311
1993 PDC activity and acetyl group accumulation in skeletal muscle during isometric contraction. Journal of applied physiology (Bethesda, Md. : 1985) 29 8514686
2017 Pyruvate dehydrogenase complex (PDC) subunits moonlight as interaction partners of phosphorylated STAT5 in adipocytes and adipose tissue. The Journal of biological chemistry 28 28982698
2016 Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state. Mucosal immunology 28 27827374
2012 Peripheral blood CD4 T-cell and plasmacytoid dendritic cell (pDC) reactivity to herpes simplex virus 2 and pDC number do not correlate with the clinical or virologic severity of recurrent genital herpes. Journal of virology 28 22761381
2005 The importance of being a pDC in antiviral immunity: the IFN mission versus Ag presentation? Trends in immunology 28 15922947
2020 Novel concepts in plasmacytoid dendritic cell (pDC) development and differentiation. Molecular immunology 27 32739721
2011 Optical mapping and sequencing of the Escherichia coli KO11 genome reveal extensive chromosomal rearrangements, and multiple tandem copies of the Zymomonas mobilis pdc and adhB genes. Journal of industrial microbiology & biotechnology 27 22075923
2008 Interaction of the major protein from bovine seminal plasma, PDC-109 with phospholipid membranes and soluble ligands investigated by fluorescence approaches. Biochimica et biophysica acta 27 18402784
1997 Analysis of T-cell receptor beta of the T-cell clones reactive to the human PDC-E2 163-176 peptide in the context of HLA-DR53 in patients with primary biliary cirrhosis. Hepatology (Baltimore, Md.) 27 9303504
2019 Hypothesis: Etiologic and Molecular Mechanistic Leads for Sporadic Neurodegenerative Diseases Based on Experience With Western Pacific ALS/PDC. Frontiers in neurology 25 31417480
2019 pDC depletion induced by CD317 blockade drives the antitumor immune response in head and neck squamous cell carcinoma. Oral oncology 25 31422204
2020 Infection and cancer suppress pDC derived IFN-I. Current opinion in immunology 24 32947131
2011 Correlation of membrane binding and hydrophobicity to the chaperone-like activity of PDC-109, the major protein of bovine seminal plasma. PloS one 24 21408153
2004 Quantitative measurement of neurodegeneration in an ALS-PDC model using MR microscopy. NeuroImage 23 15325381
2021 BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development. Developmental cell 22 33773101
2019 pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG. Journal of immunology research 22 31093508
2019 SLAMF9 regulates pDC homeostasis and function in health and disease. Proceedings of the National Academy of Sciences of the United States of America 22 31346085
2013 Bovine seminal PDC-109 protein: an overview of biochemical and functional properties. Animal reproduction science 22 23489472
2012 Sequestration of PDC-109 protein improves freezability of crossbred bull spermatozoa. Animal reproduction science 22 22397988
1999 In situ nucleic acid detection of PDC-E2, BCOADC-E2, OGDC-E2, PDC-E1alpha, BCOADC-E1alpha, OGDC-E1, and the E3 binding protein (protein X) in primary biliary cirrhosis. Hepatology (Baltimore, Md.) 22 10385636
1997 Protein design on pyruvate decarboxylase (PDC) by site-directed mutagenesis. Application to mechanistical investigations, and tailoring PDC for the use in organic synthesis. Advances in biochemical engineering/biotechnology 22 9103910
1992 Development of MEKA (phosducin), G beta, G gamma and S-antigen in the rat pineal gland and retina. Brain research 22 1511297
1989 Identification of a retina-specific MEKA protein as a 33 K protein. Biochemical and biophysical research communications 22 2764917
2019 Suppression of CpG-ODN-mediated IFNα and TNFα response in human plasmacytoid dendritic cells (pDC) by cannabinoid receptor 2 (CB2)-specific agonists. Toxicology and applied pharmacology 21 30807757
2014 Pyruvate dehydrogenase complex (PDC) export from the mitochondrial matrix. Molecular membrane biology 21 25495576
1991 Photoneural control of the synthesis and phosphorylation of pineal MEKA (phosducin). Endocrinology 21 1659528
1990 Isolation and analysis of the human MEKA gene encoding a retina-specific protein. Biochemical and biophysical research communications 21 2383274
2017 NOK mediates glycolysis and nuclear PDC associated histone acetylation. Frontiers in bioscience (Landmark edition) 20 28410146
2013 IFN-α regulates Blimp-1 expression via miR-23a and miR-125b in both monocytes-derived DC and pDC. PloS one 20 23977359
2011 The ALS/PDC syndrome of Guam: potential biomarkers for an enigmatic disorder. Progress in neurobiology 20 21527311
2010 31P NMR and AFM studies on the destabilization of cell and model membranes by the major bovine seminal plasma protein, PDC-109. IUBMB life 20 21117173

Missed literature

Know a paper Affinage missed for PDC? Flag it for the maintainers and the community.

No submissions yet.