PCDH1
Protocadherin-1 · UniProt Q08174
- Length
- 1060 aa
- Mass
- 114.7 kDa
- Annotated
- 2026-06-13
69 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 69 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2011 | Non-clustered protocadherin. | Cell adhesion & migration | 208 | 21173574 |
| 2007 | Spatiotemporal expression pattern of non-clustered protocadherin family members in the developing rat brain. | Neuroscience | 107 | 17614211 |
| 2009 | Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. | American journal of respiratory and critical care medicine | 102 | 19729670 |
| 2018 | Protocadherin-1 is essential for cell entry by New World hantaviruses. | Nature | 92 | 30464266 |
| 2013 | Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells. | Carcinogenesis | 91 | 23354309 |
| 1995 | Protocadherin Pcdh2 shows properties similar to, but distinct from, those of classical cadherins. | Journal of cell science | 88 | 8719883 |
| 2016 | The genetic and epigenetic landscapes of the epithelium in asthma. | Respiratory research | 70 | 27658857 |
| 2010 | The expression of non-clustered protocadherins in adult rat hippocampal formation and the connecting brain regions. | Neuroscience | 68 | 20541594 |
| 2021 | Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling. | Scientific reports | 67 | 34326372 |
| 2019 | Epithelial physical barrier defects in chronic rhinosinusitis. | Expert review of clinical immunology | 63 | 30925220 |
| 2017 | The role of cadherin genes in five major psychiatric disorders: A literature update. | American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics | 54 | 28921840 |
| 2010 | Cadherin expression in the somatosensory cortex: evidence for a combinatorial molecular code at the single-cell level. | Neuroscience | 50 | 21129452 |
| 2017 | Cell surface markers for the identification and study of human naive pluripotent stem cells. | Stem cell research | 41 | 29227830 |
| 2012 | Cadherin expression delineates the divisions of the postnatal and adult mouse amygdala. | The Journal of comparative neurology | 39 | 22592879 |
| 2009 | Expression of classic cadherins and delta-protocadherins in the developing ferret retina. | BMC neuroscience | 33 | 20028529 |
| 2006 | Cottontail rabbit papillomavirus E8 protein is essential for wart formation and provides new insights into viral pathogenesis. | Journal of virology | 32 | 16641280 |
| 2015 | Protocadherin-1 is a glucocorticoid-responsive critical regulator of airway epithelial barrier function. | BMC pulmonary medicine | 31 | 26227965 |
| 2008 | Expression of protocadherin-1 (Pcdh1) during mouse development. | Developmental dynamics : an official publication of the American Association of Anatomists | 31 | 18729229 |
| 1997 | Identification of novel cadherins expressed in human melanoma cells. | The Journal of investigative dermatology | 31 | 9182820 |
| 2011 | Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 30 | 21982948 |
| 2007 | Sequencing and comparative analysis of fugu protocadherin clusters reveal diversity of protocadherin genes among teleosts. | BMC evolutionary biology | 26 | 17394664 |
| 2008 | Chicken protocadherin-1 functions to localize neural crest cells to the dorsal root ganglia during PNS formation. | Mechanisms of development | 25 | 18718533 |
| 2012 | Expression of delta-protocadherins in the spinal cord of the chicken embryo. | The Journal of comparative neurology | 24 | 22102158 |
| 2015 | Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription. | American journal of physiology. Lung cellular and molecular physiology | 23 | 26209277 |
| 2010 | AKT-modified autologous intracoronary mesenchymal stem cells prevent remodeling and repair in swine infarcted myocardium. | Chinese medical journal | 23 | 20819633 |
| 2016 | Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma. | PloS one | 22 | 27701444 |
| 2013 | The PCDH1 gene and asthma in early childhood. | The European respiratory journal | 20 | 23988763 |
| 2021 | Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells. | eLife | 19 | 34232859 |
| 2022 | PCDH1 promotes progression of pancreatic ductal adenocarcinoma via activation of NF-κB signalling by interacting with KPNB1. | Cell death & disease | 18 | 35864095 |
| 2020 | Novel candidate genes in esophageal atresia/tracheoesophageal fistula identified by exome sequencing. | European journal of human genetics : EJHG | 18 | 32641753 |
| 2023 | Comprehensive lipid profiles investigation reveals host metabolic and immune alterations during anti-tuberculosis treatment: Implications for therapeutic monitoring. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 17 | 36916440 |
| 2020 | Multi-Omics Analysis Reveals Novel Subtypes and Driver Genes in Glioblastoma. | Frontiers in genetics | 15 | 33324446 |
| 2019 | Identification of an adhesive interface for the non-clustered δ1 protocadherin-1 involved in respiratory diseases. | Communications biology | 15 | 31583286 |
| 2024 | Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial homeostasis and increases antitumor activity against glioblastoma. | NPJ precision oncology | 13 | 39054369 |
| 2019 | Whole-genome resequencing reveals genetic indels of feathered-leg traits in domestic chickens. | Journal of genetics | 13 | 31204699 |
| 2018 | An extensive study of the mechanism of prostate cancer metastasis. | Neoplasma | 13 | 29534587 |
| 2011 | Protocadherin-1 polymorphisms are associated with eczema in two Dutch birth cohorts. | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology | 13 | 21929597 |
| 2012 | Genetic variants in Protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children. | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology | 12 | 23050600 |
| 2018 | Ancestral Variations of the PCDHG Gene Cluster Predispose to Dyslexia in a Multiplex Family. | EBioMedicine | 11 | 29409727 |
| 2012 | [Study on expression of PTEN gene and its pseudogene PTENP1 in acute leukemia and correlation between them]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi | 11 | 23363743 |
| 2020 | Quantitative structural analysis of glycans expressed within tumors derived from pancreatic cancer patient-derived xenograft mouse models. | Biochemical and biophysical research communications | 10 | 33288196 |
| 2012 | Anatomical expression patterns of delta-protocadherins in developing chicken cochlea. | Journal of anatomy | 10 | 22998331 |
| 2023 | Plasma untargeted metabolomics with proteinase K discloses phospholipid signature associated with pulmonary arterial hypertension. | Scientific reports | 9 | 37714912 |
| 2024 | MicroRNA-22-3p displaces critical host factors from the 5' UTR and inhibits the translation of Coxsackievirus B3 RNA. | Journal of virology | 7 | 38289119 |
| 2024 | Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV). | International journal of molecular sciences | 7 | 38673968 |
| 2021 | A High-Density Genetic Linkage Map and Fine Mapping of QTL For Feed Conversion Efficiency in Common Carp (Cyprinus carpio). | Frontiers in genetics | 7 | 34868267 |
| 2016 | Effect of miR-146a and miR-155 on cardiac xenotransplantation. | Experimental and therapeutic medicine | 7 | 28101175 |
| 2013 | Expression of multiple delta-protocadherins during feather bud formation. | Gene expression patterns : GEP | 7 | 23318466 |
| 2022 | Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content. | Journal of the American Society for Mass Spectrometry | 6 | 35545232 |
| 2023 | Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection. | Nature communications | 5 | 37488123 |
| 2020 | Transcript Profiles of Stria Vascularis in Models of Waardenburg Syndrome. | Neural plasticity | 5 | 32802035 |
| 2025 | Transcriptome and lipid metabolome of the subcutaneous fat of Tibetan sheep: A comprehensive analysis of the reduction in fat deposition upon resveratrol and β-hydroxy-β-methyl butyric acid supplementation. | Genomics | 3 | 40633702 |
| 2024 | Mapping combinatorial expression of non-clustered protocadherins in the developing brain identifies novel PCDH19-mediated cell adhesion properties. | Open biology | 3 | 38629124 |
| 2021 | Protocadherin-1 is expressed in the notochord of mouse embryo but is dispensable for its formation. | Biochemistry and biophysics reports | 3 | 34189280 |
| 2024 | Germ-free status but not subacute polychlorinated biphenyl (PCB) exposure altered hepatic phosphatidylcholine and ether-phosphatidylcholine levels in mice. | Toxicology | 2 | 38552894 |
| 2024 | Identification of Chronic Pancreatitis Associated microRNAs and Genes for the Diagnosis of Pancreatic Cancer. | The American surgeon | 2 | 38708574 |
| 2024 | Reactive astrocytes promote tumor progression by up-regulating tumor protocadherin 1 expression in lung cancer brain metastasis. | Biochemical and biophysical research communications | 2 | 39047401 |
| 2024 | Whole genome sequencing reveals candidate causal genetic variants for spastic syndrome in Holstein cattle. | Scientific reports | 2 | 39732776 |
| 2013 | Fast preparation of a polyclonal antibody against chicken protocadherin 1. | Genetics and molecular research : GMR | 2 | 23913393 |
| 2004 | Studies on protocadherin-2 expression in the human fetal central nervous system. | Congenital anomalies | 2 | 15327484 |
| 2023 | Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer. | Frontiers in genetics | 1 | 37082114 |
| 2023 | Genetic Landscape of Masticatory Muscle Tendon-Aponeurosis Hyperplasia. | Genes | 1 | 37761858 |
| 2026 | The involvement of Th17 inflammation and miR-363-3p in airway epithelial barrier dysfunction. | Respiratory research | 0 | 41540423 |
| 2026 | PCDH1 facilitates migration, proliferation, and stemness of pancreatic cancer cells through PI3K-Akt signaling. | Frontiers in oncology | 0 | 41602375 |
| 2026 | Protocadherin 1 (PCDH1) Promotes Pancreatic Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition (EMT) Progression Through the NF-κB Pathway. | Cancer management and research | 0 | 42005443 |
| 2026 | FGFR4-high expression is associated with an immune-responsive phenotype in HCC and predicts inferior efficacy of lenvatinib plus PD-1 blockade. | BMC cancer | 0 | 42104313 |
| 2025 | Proteome analysis of preserved formalin-fixed and paraffin-embedded specimens to explore the pathogenesis of infantile hypertrophic pyloric stenosis. | Pediatric surgery international | 0 | 40839121 |
| 2025 | Comparative transcriptome profiling of peripheral blood mononuclear cells suggests Protocadherin-1 (PCDH1) as a distinctive innate immunity signature in Sahiwal, Tharparkar and Gir compared to Karan Fries cattle. | Developmental and comparative immunology | 0 | 41213348 |
| 2014 | [Role of IFN-γ in the regulation of murine hemopoiesis]. | Zhongguo shi yan xue ye xue za zhi | 0 | 24989263 |
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