- Length
- 1178 aa
- Mass
- 129.6 kDa
- Annotated
- 2026-04-29
130 papers in source corpus
17 papers cited in narrative
16 extracted findings
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
Insufficient on-target evidence to synthesize a narrative — discovery timeline does not match the canonical PC protein.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Evidence
Reading pass · 16 per-paper findings extracted from the source corpus
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 1979 | Human protein C was isolated from plasma and shown to be a vitamin K-dependent zymogen composed of a disulfide-linked light chain (Mr ~21,000) and heavy chain (Mr ~41,000). Activation by alpha-thrombin produces a serine protease with amidolytic and anticoagulant activity through limited proteolysis of the heavy chain, with the active-site serine residing in the heavy chain. | Protein purification (barium citrate adsorption, DEAE-Sephadex, dextran sulfate agarose chromatography), SDS-PAGE, NH2-terminal sequencing, DFP active-site labeling, clotting assays | The Journal of clinical investigation | High | 468991 |
| 1984 | Cloning of human protein C cDNA established that the protein is synthesized as a single-chain precursor containing the light chain and heavy chain connected by a Lys-Arg dipeptide; post-translational cleavage of this dipeptide and disulfide bond formation generate the mature two-chain plasma form. The catalytic domain shows high sequence identity with prothrombin, factor IX, and factor X. | Lambda gt11 cDNA library screening with anti-protein C antibody, DNA sequencing (dideoxy), amino acid sequence analysis | Proceedings of the National Academy of Sciences of the United States of America | High | 6589623 |
| 1985 | The human protein C gene spans ~11 kilobases and consists of eight exons and seven introns encoding a preproleader sequence, light chain, Lys-Arg connecting dipeptide, and heavy chain (serine protease catalytic domain). Intron positions are conserved with factor IX, indicating recent gene duplication within the vitamin K-dependent serine protease family. | Genomic library screening, dideoxy sequencing of overlapping lambda phage clones spanning 11 kb | Proceedings of the National Academy of Sciences of the United States of America | High | 2991887 |
| 1986 | Detailed genomic analysis revealed that the human protein C gene has nine exons and eight introns spanning at least 11.2 kb, with two EGF-homology regions (amino acids 46–91 and 92–136) each precisely delimited by introns — a domain organization shared exactly with factor IX and tissue plasminogen activator, demonstrating modular exon shuffling in the coagulation protease family. | Isolation of overlapping phage genomic clones, complete sequence determination, intron/exon boundary mapping | Proceedings of the National Academy of Sciences of the United States of America | High | 3511471 |
| 1989 | Protein C is activated on endothelial cell surfaces by thrombin bound to thrombomodulin; activated protein C (APC) then functions as an anticoagulant serine protease that inactivates factors Va and VIIIa, and protein S serves as a cofactor for APC. This established the protein C anticoagulant pathway as a key regulatory system for blood coagulation. | Biochemical reconstitution with purified components, activity assays, cofactor studies | The Journal of biological chemistry | High | 2538457 |
| 1991 | APC inactivates human factor VIIIa by proteolytic cleavage within the A1 and A2 subunits of the heavy chain at Arg336 and Arg562 (with a third site at Arg740). Cleavage at Arg562 correlates most closely with loss of cofactor activity and promotes dissociation of the A2 domain from the A1/light chain dimer, establishing a two-step mechanism for factor VIII inactivation. | In vitro proteolysis with purified APC, SDS-PAGE fragment analysis, NH2-terminal sequencing, anti-A2 monoclonal antibody reactivity, gel filtration | The Journal of biological chemistry | High | 1939075 |
| 1991 | Genetic defects causing hereditary protein C deficiency type I in Dutch families are heterogeneous point mutations throughout the protein C gene; six mutations recur in multiple families, with the most frequent showing a founder effect. This established the molecular basis of thrombosis risk from protein C haploinsufficiency. | DNA sequencing of protein C gene in 40 probands, mutation analysis | Blood | High | 1868249 |
| 1994 | APC inactivates human factor Va on phospholipid membranes through sequential cleavages at Arg306, Arg506, Arg679, and Lys994 in the heavy chain. Cleavage at Arg506 precedes and is required for cleavage at Arg306 (the critical inactivating cut), and membrane binding is absolutely required for efficient inactivation — membrane-free factor Va retains ~80% cofactor activity after 2 h of APC treatment. | In vitro proteolysis with purified components and PCPS vesicles, SDS-PAGE, NH2-terminal sequencing of fragments, functional cofactor activity assays | The Journal of biological chemistry | High | 7989361 |
| 1996 | The 2.8 Å crystal structure of Gla-domainless APC revealed: (1) the light chain comprises two EGF-like domains arranged at ~80° to each other; (2) the catalytic domain is trypsin-like but contains a large insertion loop at the active site edge, a third helical segment, a prominent cationic patch (analogous to thrombin's anion-binding exosite I), and a Ca²⁺-binding site; (3) the S2 and S4 subsites are more polar than in factor Xa or thrombin, explaining APC's distinct substrate specificity. | X-ray crystallography at 2.8 Å resolution | The EMBO journal | High | 9003757 |
| 2002 | APC uses the endothelial cell protein C receptor (EPCR) as a coreceptor to cleave protease-activated receptor 1 (PAR1) on endothelial cells, triggering cytoprotective gene expression including selective induction of MCP-1. This established that PAR1 is the signaling receptor for the EPCR-dependent APC pathway and distinguishes APC's anti-inflammatory signaling from its anticoagulant functions. | Gene profiling of APC-stimulated endothelial cells, PAR1/PAR2 receptor-specific assays, EPCR blocking studies | Science (New York, N.Y.) | High | 12052963 |
| 2003 | APC directly prevents apoptosis in hypoxic human brain endothelium through transcriptional inhibition of p53, normalization of the Bax/Bcl-2 ratio, and reduction of caspase-3 signaling. This cytoprotection requires both EPCR and PAR-1, and in vivo neuroprotection in a mouse stroke model was EPCR-dependent and independent of APC's anticoagulant activity. | Hypoxia cell model, gene/protein expression analysis (p53, Bax, Bcl-2, caspase-3), EPCR/PAR-1 blocking antibodies, EPCR-deficient mouse stroke model | Nature medicine | High | 12563316 |
| 2004 | Thrombomodulin on endothelial cell surfaces acts as the critical cofactor for thrombin-mediated protein C activation; EPCR further amplifies this activation. APC then exerts anticoagulant effects by degrading FVa and FVIIIa on negatively charged phospholipid membranes with protein S as cofactor, and separately exerts anti-inflammatory/antiapoptotic effects via EPCR-PAR1 signaling. These functions are integrated to maintain hemostatic homeostasis. | Review synthesizing biochemical, cell biology, and mouse genetic studies | Arteriosclerosis, thrombosis, and vascular biology | High | 15178554 |
| 2005 | APC mediates endothelial barrier enhancement through EPCR ligation followed by transactivation of sphingosine 1-phosphate receptor 1 (S1P1), leading to Rac1 GTPase activation, cortical actin polymerization, and increased myosin light chain phosphorylation. Co-immunoprecipitation showed EPCR-S1P1 interaction upon APC treatment; S1P1 siRNA silencing significantly reduced APC barrier protection. | Transendothelial electrical resistance measurements, Rac1 activity assays, co-immunoprecipitation, siRNA knockdown of S1P1, EPCR-blocking antibody, cortical actin imaging | The Journal of biological chemistry | High | 15710622 |
| 2005 | APC cleaves PAR1 on endothelial cells in an EPCR-dependent manner but is ~10,000-fold less potent than thrombin at PAR1 cleavage. Both APC and thrombin trigger PAR1-dependent gene induction (antiapoptotic and chemokine genes), but at physiological concentrations APC does not significantly contribute to PAR1 cleavage beyond that of thrombin. APC also cleaves PAR2 via canonical cleavage, though PAR1 remains dominant for APC signaling even when PAR2 is upregulated. | PAR1 cleavage kinetics on endothelial cell surfaces, EPCR antibody blocking, gene expression analysis, PAR1⁻/⁻ mouse studies | The Journal of biological chemistry | High | 15665002 15769747 |
| 2005 | Structural and molecular recognition analysis of the protein C system established that protein S is an essential cofactor for APC-mediated degradation of FVIIIa and FVa on phospholipid membranes, and that intact factor V (in addition to protein S) is required for efficient FVIIIa degradation, revealing FV as a Janus-faced protein with both procoagulant and anticoagulant potential. | Review integrating biochemical reconstitution, structural data (3D structures of protein C system components), and mutagenesis studies | Arteriosclerosis, thrombosis, and vascular biology | High | 15860736 |
| 2007 | In diabetic mice, thrombomodulin-dependent APC formation is reduced, and this reduction is causally linked to nephropathy. APC prevents glucose-induced apoptosis in glomerular endothelial cells and podocytes via modulation of the mitochondrial apoptosis pathway through PAR-1 and EPCR. Maintaining high APC levels during long-term diabetes protects against nephropathy, establishing the thrombomodulin-PC-EPCR axis as a protective pathway in diabetic end-organ damage. | Diabetic mouse models (thrombomodulin-deficient and APC-overexpressing), glomerular apoptosis assays, endothelial cell and podocyte culture with glucose stress, PAR-1/EPCR inhibition | Nature medicine | High | 17982464 |
Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 1989 | The roles of protein C and thrombomodulin in the regulation of blood coagulation. | The Journal of biological chemistry | 927 | 2538457 |
| 2020 | A reference map of the human binary protein interactome. | Nature | 849 | 32296183 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2002 | Activation of endothelial cell protease activated receptor 1 by the protein C pathway. | Science (New York, N.Y.) | 704 | 12052963 |
| 2004 | The human plasma proteome: a nonredundant list developed by combination of four separate sources. | Molecular & cellular proteomics : MCP | 658 | 14718574 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 1979 | Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin. | The Journal of clinical investigation | 526 | 468991 |
| 2003 | Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. | Nature medicine | 480 | 12563316 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 2005 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | Genome research | 409 | 16344560 |
| 1996 | Normalization and subtraction: two approaches to facilitate gene discovery. | Genome research | 401 | 8889548 |
| 1985 | The nucleotide sequence of the gene for human protein C. | Proceedings of the National Academy of Sciences of the United States of America | 385 | 2991887 |
| 2005 | Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. | Journal of proteome research | 350 | 16335952 |
| 1994 | The mechanism of inactivation of human factor V and human factor Va by activated protein C. | The Journal of biological chemistry | 347 | 7989361 |
| 2007 | Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. | Nature medicine | 326 | 17982464 |
| 2005 | Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation. | The Journal of biological chemistry | 314 | 15710622 |
| 2006 | Association of warfarin dose with genes involved in its action and metabolism. | Human genetics | 299 | 17048007 |
| 2004 | Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation. | Arteriosclerosis, thrombosis, and vascular biology | 298 | 15178554 |
| 1998 | Stepping backward to improve assessment of PCB congener toxicities. | Environmental health perspectives | 266 | 9539012 |
| 2011 | A directed protein interaction network for investigating intracellular signal transduction. | Science signaling | 258 | 21900206 |
| 2005 | Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition. | Arteriosclerosis, thrombosis, and vascular biology | 246 | 15860736 |
| 1986 | Evolution and organization of the human protein C gene. | Proceedings of the National Academy of Sciences of the United States of America | 198 | 3511471 |
| 1996 | The 2.8 A crystal structure of Gla-domainless activated protein C. | The EMBO journal | 197 | 9003757 |
| 2009 | Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. | Pharmacology & therapeutics | 184 | 19931307 |
| 1984 | Characterization of a cDNA coding for human protein C. | Proceedings of the National Academy of Sciences of the United States of America | 183 | 6589623 |
| 1991 | Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity. | The Journal of biological chemistry | 169 | 1939075 |
| 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | American journal of human genetics | 164 | 19913121 |
| 2005 | Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling. | The Journal of biological chemistry | 163 | 15769747 |
| 2005 | PAR1 cleavage and signaling in response to activated protein C and thrombin. | The Journal of biological chemistry | 155 | 15665002 |
| 1991 | The spectrum of genetic defects in a panel of 40 Dutch families with symptomatic protein C deficiency type I: heterogeneity and founder effects. | Blood | 153 | 1868249 |
| 2007 | Prenatal pesticide and PCB exposures and birth outcomes. | Pediatric research | 135 | 17237730 |
| 2012 | PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. | Environmental health perspectives | 113 | 22534141 |
| 2020 | Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB) Developmental Neurotoxicity. | International journal of molecular sciences | 93 | 32033061 |
| 1999 | Effects of the antiestrogenic environmental pollutant 3,3',4,4', 5-pentachlorobiphenyl (PCB #126) in rat bone and uterus: diverging effects in ovariectomized and intact animals. | Toxicology and applied pharmacology | 90 | 9931283 |
| 2007 | CABAS: a freely available PC program for fitting calibration curves in chromosome aberration dosimetry. | Radiation protection dosimetry | 88 | 18073230 |
| 1997 | Structure-activity relationships of potentially neurotoxic PCB congeners in the rat. | Neurotoxicology | 85 | 9291492 |
| 1996 | Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals. | The American journal of physiology | 85 | 8897914 |
| 2003 | Prenatal PCB exposure, the corpus callosum, and response inhibition. | Environmental health perspectives | 81 | 14527849 |
| 2011 | Individual polychlorinated biphenyl (PCB) congeners produce tissue- and gene-specific effects on thyroid hormone signaling during development. | Endocrinology | 75 | 21540284 |
| 1999 | Phthalocyanine 4 (Pc 4) photodynamic therapy of human OVCAR-3 tumor xenografts. | Photochemistry and photobiology | 75 | 10048316 |
| 2014 | The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 71 | 24431430 |
| 1998 | Release of dopamine and norepinephrine by hypoxia from PC-12 cells. | The American journal of physiology | 69 | 9611124 |
| 2003 | Locating and quantifying PCB sources in Chicago: receptor modeling and field sampling. | Environmental science & technology | 67 | 12636265 |
| 1983 | Regulation of peripherin in mouse neuroblastoma and rat PC 12 pheochromocytoma cell lines. | Developmental neuroscience | 67 | 6151488 |
| 2006 | From environment to food: the case of PCB. | Annali dell'Istituto superiore di sanita | 65 | 17361063 |
| 2020 | The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus. | eLife | 63 | 33164752 |
| 2013 | Induction of cytoprotective autophagy in PC-12 cells by cadmium. | Biochemical and biophysical research communications | 58 | 23880342 |
| 2001 | Fate of PCDF/PCB congeners and change of clinical symptoms in patients with Yusho PCB poisoning for 30 years. | Chemosphere | 56 | 11372885 |
| 1999 | Antioxidant protection against PCB-mediated endothelial cell activation. | Toxicological sciences : an official journal of the Society of Toxicology | 55 | 10630576 |
| 2019 | Acrylonitrile butadiene styrene (ABS) and polycarbonate (PC) filaments three-dimensional (3-D) printer emissions-induced cell toxicity. | Toxicology letters | 54 | 31562913 |
| 1993 | Divergence of signaling pathways for insulin in PC-12 pheochromocytoma cells. | Endocrinology | 53 | 7686484 |
| 2012 | Selection and characterization of PCB-binding DNA aptamers. | Analytical chemistry | 51 | 22166135 |
| 2009 | Effect of chitooligosaccharide on neuronal differentiation of PC-12 cells. | Cell biology international | 48 | 19272331 |
| 2011 | Photodynamic therapy with Pc 4 induces apoptosis of Candida albicans. | Photochemistry and photobiology | 47 | 21521233 |
| 2006 | Fasting augments PCB impact on liver metabolism in anadromous arctic char. | Toxicological sciences : an official journal of the Society of Toxicology | 47 | 16537658 |
| 2011 | Serum PCB levels and congener profiles among teachers in PCB-containing schools: a pilot study. | Environmental health : a global access science source | 46 | 21668970 |
| 2014 | Evolved resistance to PCB- and PAH-induced cardiac teratogenesis, and reduced CYP1A activity in Gulf killifish (Fundulus grandis) populations from the Houston Ship Channel, Texas. | Aquatic toxicology (Amsterdam, Netherlands) | 45 | 24699180 |
| 2009 | RNA localization and polarity: from A(PC) to Z(BP). | Trends in cell biology | 44 | 19251418 |
| 1979 | Biochemical and ultrastructural changes in teleost liver following subacute exposure to PCB. | Journal of environmental pathology and toxicology | 44 | 109562 |
| 2015 | Cofilin-phosphatase slingshot-1L (SSH1L) is over-expressed in pancreatic cancer (PC) and contributes to tumor cell migration. | Cancer letters | 43 | 25684665 |
| 2010 | PC-TP/StARD2: Of membranes and metabolism. | Trends in endocrinology and metabolism: TEM | 42 | 20338778 |
| 2008 | Genotoxic effects of PCB 52 and PCB 77 on cultured human peripheral lymphocytes. | Mutation research | 40 | 18573685 |
| 2006 | Coping with polychlorinated biphenyl (PCB) toxicity: Physiological and genome-wide responses of Burkholderia xenovorans LB400 to PCB-mediated stress. | Applied and environmental microbiology | 39 | 17021212 |
| 2020 | Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2. | Diabetes | 38 | 32291281 |
| 2016 | Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer. | Molecular cancer therapeutics | 38 | 27638860 |
| 2014 | Biomarkers linking PCB exposure and obesity. | Current pharmaceutical biotechnology | 38 | 25420728 |
| 2002 | Sulfhydryl binding and topoisomerase inhibition by PCB metabolites. | Chemical research in toxicology | 38 | 11952335 |
| 1998 | Membrane glycoprotein PC-1 and insulin resistance. | Molecular and cellular biochemistry | 37 | 9609127 |
| 2020 | Gut Microbiome Critically Impacts PCB-induced Changes in Metabolic Fingerprints and the Hepatic Transcriptome in Mice. | Toxicological sciences : an official journal of the Society of Toxicology | 35 | 32544245 |
| 2016 | Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy. | Environmental science & technology | 35 | 26876502 |
| 2002 | PCB sources, transformations, and contributions in recent Fox River, Wisconsin sediments determined from receptor modeling. | Water research | 34 | 12230190 |
| 2015 | Polychlorinated Biphenyls (PCB 101, 153, and 180) Impair Murine Macrophage Responsiveness to Lipopolysaccharide: Involvement of NF-κB Pathway. | Toxicological sciences : an official journal of the Society of Toxicology | 33 | 26141388 |
| 2014 | Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites. | Environmental science & technology | 32 | 24467194 |
| 2013 | Influence of nutrition in PCB-induced vascular inflammation. | Environmental science and pollution research international | 32 | 23417440 |
| 1996 | Polychlorinated biphenyl (PCB) and dichlorodiphenyl dichloroethylene (DDE) exposure among Native American men from contaminated Great Lakes fish and wildlife. | Toxicology and industrial health | 32 | 8843553 |
| 2018 | Stereoselective bioaccumulation of chiral PCB 91 in earthworm and its metabolomic and lipidomic responses. | Environmental pollution (Barking, Essex : 1987) | 31 | 29587213 |
| 2015 | Autophagy regulates colistin-induced apoptosis in PC-12 cells. | Antimicrobial agents and chemotherapy | 31 | 25645826 |
| 1994 | Genetic construction of PCB degraders. | Biodegradation | 31 | 7765843 |
| 2019 | Novel miRNA PC-5P-12969 in Ischemic Stroke. | Molecular neurobiology | 29 | 30953313 |
| 2020 | Biomarkers of metabolic disorders and neurobehavioral diseases in a PCB- exposed population: What we learned and the implications for future research. | Environmental research | 28 | 32937175 |
| 2007 | Dietary exposure to methyl mercury and PCB and the associations with semen parameters among Swedish fishermen. | Environmental health : a global access science source | 28 | 17488503 |
| 2021 | Printable graphene BioFETs for DNA quantification in Lab-on-PCB microsystems. | Scientific reports | 27 | 33972649 |
| 2017 | MicroRNA-210 Protects PC-12 Cells Against Hypoxia-Induced Injury by Targeting BNIP3. | Frontiers in cellular neuroscience | 27 | 29018330 |
| 2017 | Intestinal exposure to PCB 153 induces inflammation via the ATM/NEMO pathway. | Toxicology and applied pharmacology | 27 | 29197519 |
| 2014 | PCB 126 toxicity is modulated by cross-talk between caveolae and Nrf2 signaling. | Toxicology and applied pharmacology | 27 | 24709675 |
| 2014 | Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats. | PloS one | 27 | 25137063 |
| 1996 | Threonine autophosphorylation and nucleotidylation of the hepatic membrane protein PC-1. | European journal of biochemistry | 27 | 8917428 |
| 2019 | The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics. | Biomaterials | 26 | 31048198 |
| 2018 | 3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. | Archives of toxicology | 26 | 30225637 |
| 1999 | Role of PC-1 in the etiology of insulin resistance. | Annals of the New York Academy of Sciences | 26 | 10842664 |
| 2023 | Ferroptosis of CD163+ tissue-infiltrating macrophages and CD10+ PC+ epithelial cells in lupus nephritis. | Frontiers in immunology | 25 | 37583695 |
| 2019 | Notoginsenoside R1 alleviates lipopolysaccharide-triggered PC-12 inflammatory damage via elevating microRNA-132. | Artificial cells, nanomedicine, and biotechnology | 25 | 31062615 |
| 2016 | Amperometric IFN-γ immunosensors with commercially fabricated PCB sensing electrodes. | Biosensors & bioelectronics | 25 | 27479047 |
| 2005 | Low dose hydroxylated PCB induces c-Jun expression in PC12 cells. | Neurotoxicology | 25 | 16300829 |
| 2018 | The glycerophosphocholine acyltransferase Gpc1 is part of a phosphatidylcholine (PC)-remodeling pathway that alters PC species in yeast. | The Journal of biological chemistry | 24 | 30514764 |
| 1998 | Subchronic toxicity of PCB 105 (2,3,3',4,4'-pentachlorobiphenyl) in rats. | Journal of applied toxicology : JAT | 24 | 9719429 |
| 2019 | Ultrafast, low-power, PCB manufacturable, continuous-flow microdevice for DNA amplification. | Analytical and bioanalytical chemistry | 23 | 31161322 |
| 2019 | Effects of PCB exposure on serum thyroid hormone levels in dogs and cats. | The Science of the total environment | 23 | 31726548 |
| 2017 | A comparative evaluation of anaerobic dechlorination of PCB-118 and Aroclor 1254 in sediment microcosms from three PCB-impacted environments. | Journal of hazardous materials | 23 | 28800567 |
| 2007 | PPARalpha ligands reduce PCB-induced endothelial activation: possible interactions in inflammation and atherosclerosis. | Cardiovascular toxicology | 23 | 17955387 |
| 2015 | Deviant development of pancreatic beta cells from embryonic exposure to PCB-126 in zebrafish. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP | 22 | 26393762 |
| 2020 | Enzyme-assisted glucose quantification for a painless Lab-on-PCB patch implementation. | Biosensors & bioelectronics | 21 | 32798807 |
| 2014 | Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126). | International journal of molecular sciences | 21 | 25116688 |
| 2008 | Estrogenic effect of dioxin-like aryl hydrocarbon receptor (AhR) agonist (PCB congener 126) in salmon hepatocytes. | Marine environmental research | 21 | 18378297 |
| 2001 | Omiga: a PC-based sequence analysis tool. | Molecular biotechnology | 21 | 11697223 |
| 2020 | The review of Lab-on-PCB for biomedical application. | Electrophoresis | 20 | 31945803 |
| 2019 | Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells. | BMC cancer | 19 | 31023247 |
| 2018 | Assessment of antibacterial efficacy of a biocompatible nanoparticle PC@AgNPs against Staphylococcus aureus. | Microbial pathogenesis | 19 | 30366128 |
| 2017 | Isoliquiritigenin Induces Cytotoxicity in PC-12 Cells In Vitro. | Applied biochemistry and biotechnology | 19 | 28488118 |
| 2017 | Physical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice. | The journal of physiological sciences : JPS | 19 | 28710665 |
| 2022 | Metabolism of 3-Chlorobiphenyl (PCB 2) in a Human-Relevant Cell Line: Evidence of Dechlorinated Metabolites. | Environmental science & technology | 18 | 35994059 |
| 2021 | Cytotoxicity of adducts formed between quercetin and methylglyoxal in PC-12 cells. | Food chemistry | 18 | 33706136 |
| 2020 | Genome-wide DNA methylation differences and polychlorinated biphenyl (PCB) exposure in a US population. | Epigenetics | 18 | 32660331 |
| 2018 | Patterns of PCB exposure among Akwesasne adolescents: The role of dietary and inhalation pathways. | Environment international | 18 | 30359956 |
| 2004 | Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153. | Toxicologic pathology | 18 | 15223772 |
| 2023 | Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment. | Environmental research | 17 | 36608759 |
| 2018 | Hyperpigmentation and higher incidence of cutaneous malignancies in moderate-high PCB- and dioxin exposed individuals. | Environmental research | 17 | 29501832 |
| 2015 | Inhibition of Transient Receptor Potential Melastain 7 Enhances Apoptosis Induced by TRAIL in PC-3 cells. | Asian Pacific journal of cancer prevention : APJCP | 17 | 26028116 |
| 2005 | Protective effects of Vitamin E on endocrine disruptors, PCB-induced dopaminergic neurotoxicity. | Toxicology | 17 | 16182432 |
| 2024 | Circulating perturbation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) is associated to cardiac remodeling and NLRP3 inflammasome in cardiovascular patients with insulin resistance risk. | Experimental and molecular pathology | 16 | 38703553 |
| 2022 | PC-Phos Enabled Catalytic Palladium-heteroallyl Asymmetric Cycloaddition. | Journal of the American Chemical Society | 16 | 36254467 |
| 2021 | Polychlorinated biphenyl congener 180 (PCB 180) regulates mitotic clonal expansion and enhances adipogenesis through modulation of C/EBPβ SUMOylation in preadipocytes. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association | 16 | 33864839 |
| 2020 | Towards PCB-Based Miniaturized Thermocyclers for DNA Amplification. | Micromachines | 16 | 32121172 |
| 2020 | Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. | Lab on a chip | 16 | 32319460 |
| 2016 | Mechanochemical remediation of PCB contaminated soil. | Chemosphere | 16 | 27810532 |
| 2006 | Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95). | Neurotoxicology | 16 | 17023049 |
| 2021 | Mussels drive polychlorinated biphenyl (PCB) biomagnification in a coastal food web. | Scientific reports | 15 | 33911140 |
| 2024 | Physiological response of mussel to rayon microfibers and PCB's exposure: Overlooked semi-synthetic micropollutant? | Journal of hazardous materials | 14 | 38554520 |