Affinage

PAGR1

PAXIP1-associated glutamate-rich protein 1 · UniProt Q9BTK6

Length
254 aa
Mass
27.7 kDa
Annotated
2026-06-10
100 papers in source corpus 6 papers cited in narrative 6 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PAGR1 (PA1) is a nuclear protein that functions as a transcriptional and chromatin regulator, operating principally as the main functional partner of PTIP/PAXIP1 in a PTIP-PA1 subcomplex that can act independently of the associated MLL3/MLL4 histone methyltransferase complex (PMID:26744420). Through this subcomplex it promotes transcription at the immunoglobulin heavy chain locus during class switch recombination (PMID:26744420) and, via a conserved FDF motif in PAGR1, drives global chromatin association of cohesin on active promoters and enhancers, a function whose loss aggravates cohesion defects to the point of mitotic death in ESCO2-mutant cells (PMID:37702151). PAGR1 also serves as a context-specific modulator of nuclear receptor signaling: it binds the C-terminal half of the glucocorticoid receptor and acts as a competitive decelerator of GR transactivation, lowering maximal agonist activity and altering GR occupancy at endogenous targets such as IGFBP1 and IP6K3 (PMID:23161582), yet in the early phase of adipogenesis it cooperates with phospho-CREB and ligand-activated GR to induce C/EBPβ and C/EBPδ and is required for adipocyte and Myf5+ lineage development (PMID:32601106). In Sertoli cells, PAGR1 maintains blood-testis barrier integrity by interacting with the AP-1 factor JUN to regulate Connexin43 expression (PMID:35379345). Consistent with these broad developmental roles, bi-allelic PAGR1 missense variants cause severe microcephaly and neurodevelopmental disorder in humans, and murine knockout is embryonic lethal (PMID:34585832).

Mechanistic history

Synthesis pass · year-by-year structured walk · 6 steps
  1. 2012 High

    Established that beyond its chromatin-complex association PAGR1 directly tunes nuclear receptor output, answering how it intersects with hormone signaling.

    Evidence Reporter assays, TIF2/SMRT competition, binding assays, and ChIP/re-ChIP on endogenous GR targets

    PMID:23161582

    Open questions at the time
    • Structural basis of PA1 binding to the GR C-terminal half not resolved
    • Whether GR deceleration is PTIP-independent in all contexts not established
    • No genome-wide map of GR genes affected
  2. 2016 High

    Defined PA1 as the principal functional partner of the PTIP BRCT domains and showed the PTIP-PA1 subcomplex can act separately from MLL3/MLL4, clarifying the modular architecture of PTIP-associated transcription.

    Evidence Quantitative proteomics, genetic dissection of PTIP, and CSR functional assays in primary lymphocytes

    PMID:26744420

    Open questions at the time
    • Molecular mechanism by which the subcomplex promotes transcription at the IgH locus unresolved
    • Direct DNA/chromatin contacts of PA1 not mapped
  3. 2020 High

    Showed PAGR1 is genetically required for adipogenesis and lineage development, moving it from in vitro transcriptional modulator to a developmental driver acting upstream of C/EBP factors.

    Evidence Conditional knockout in white/brown preadipocytes and Myf5+ cells with C/EBPβ/PPARγ rescue

    PMID:32601106

    Open questions at the time
    • Direct chromatin targets of the PAGR1/phospho-CREB/GR cooperation not defined
    • Mechanism linking PAGR1 to CREB phosphorylation status unknown
  4. 2021 Medium

    Linked PAGR1 to human disease, establishing an essential developmental requirement for the gene.

    Evidence Exome/genome sequencing in two families identifying a shared homozygous missense variant, with cited murine knockout lethality

    PMID:34585832

    Open questions at the time
    • No functional reconstitution of the p.Ser92Gly variant
    • Single report, two families
    • Mechanism connecting PAGR1 loss to microcephaly not established
  5. 2022 High

    Identified a tissue-specific role in blood-testis barrier maintenance and a new transcriptional partner (JUN), broadening PAGR1's regulatory repertoire beyond PTIP and GR.

    Evidence Sertoli-specific conditional knockout, transcriptomics, CUT&TAG, and PA1-JUN co-immunoprecipitation

    PMID:35379345

    Open questions at the time
    • PA1-JUN interaction shown by single co-IP without reciprocal/structural validation
    • Whether Cx43 regulation requires the PTIP complex unknown
  6. 2023 High

    Demonstrated a replication-independent role for the PAXIP1-PAGR1 complex in loading cohesin globally, defining a distinct chromatin-organization function requiring the PAGR1 FDF motif.

    Evidence CRISPR synthetic lethality screens, siRNA depletion, ChIP-seq co-localization, and FDF motif mapping in ESCO2-mutant cells

    PMID:37702151

    Open questions at the time
    • How the complex mechanistically recruits or stabilizes cohesin not resolved
    • Direct PAGR1-cohesin contacts not biochemically defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PAGR1's distinct activities — PTIP subcomplex transcription, cohesin loading, GR deceleration, adipogenic induction, and JUN-dependent barrier regulation — are coordinated or selected in different cell types remains unresolved.
  • No unifying biochemical model linking the partner-specific functions
  • No structure of PAGR1 or its complexes
  • Mechanism of context-dependent partner choice unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 4 GO:0060089 molecular transducer activity 1 GO:0098772 molecular function regulator activity 1
Localization
GO:0005634 nucleus 4
Pathway
R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1266738 Developmental Biology 2 R-HSA-168256 Immune System 1 R-HSA-4839726 Chromatin organization 1
Partners
JUNNR3C1PAXIP1
Complex memberships
MLL3/MLL4 (MLL2/MLL3) histone methyltransferase complexPTIP-PA1 subcomplex

Evidence

Reading pass · 6 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 PAGR1 (PA1) forms a subcomplex with PTIP that functions independently from the associated MLL3/MLL4 histone methyltransferase complex to promote transcription at the immunoglobulin heavy chain locus during class switch recombination (CSR). A tandem BRCT domain of PTIP was identified as sufficient for CSR and PA1 was identified as its main functional protein partner by quantitative proteomics in primary lymphocytes. Quantitative proteomics, genetic dissection of PTIP structural requirements, primary lymphocyte functional assays (CSR), biochemical separation of complexes Genes & development High 26744420
2012 PAGR1 (PA1) acts as a competitive decelerator of glucocorticoid receptor (GR) transactivation, suppressing agonist maximal activity (Amax), increasing EC50, and reducing partial agonist activity (PAA) of an exogenous reporter. PA1 binds strongly to the C-terminal half of GR, acts independently of associated PTIP, reverses effects of coactivator TIF2, and inhibits endogenous GR target genes (IGFBP1, IP6K3) via distinct mechanisms: increasing GR dissociation from the IGFBP1 promoter while blocking GR binding at the IP6K3 promoter, as shown by ChIP and re-ChIP. Reporter gene assays, competition assays with TIF2 and SMRT, co-immunoprecipitation/binding assays, ChIP and re-ChIP on endogenous genes The Journal of biological chemistry High 23161582
2020 PAGR1 cooperates with phosphorylated CREB and ligand-activated glucocorticoid receptor to directly control the induction of C/EBPβ and C/EBPδ transcription factors in the early phase of adipogenesis. Deletion of Pagr1 in white and brown preadipocytes prevents induction of C/EBPβ and C/EBPδ and causes severe adipogenesis defects, which can be rescued by ectopic expression of C/EBPβ or PPARγ. Deletion of Pagr1 in Myf5+ precursor cells impairs brown adipose tissue and muscle development. Conditional gene knockout in preadipocytes, ectopic expression rescue experiments, transcription factor induction assays, genetic deletion in Myf5+ lineage in vivo Molecular and cellular biology High 32601106
2023 PAXIP1 (PTIP)-PAGR1 complex promotes global chromatin association of cohesin independent of DNA replication. Depletion of PAXIP1 severely aggravates cohesion defects in ESCO2 mutant cells, leading to mitotic cell death. This cohesin regulatory function requires PAGR1 and a conserved FDF motif in PAGR1. PAXIP1 co-localizes with cohesin on active gene promoters and enhancers. CRISPR synthetic lethality screens, siRNA depletion, ChIP-seq co-localization, analysis of cohesion defects in ESCO2 mutant cell lines, domain-function mapping (FDF motif requirement) Nucleic acids research High 37702151
2022 PA1 is required for blood-testis barrier (BTB) integrity in Sertoli cells. Sertoli cell-specific Pa1 knockout in mice caused azoospermia-like phenotype with cytoskeletal disorganization at ectoplasmic specializations and BTB disruption. Transcriptomic and CUT&TAG analyses showed PA1 regulates expression of BTB-associated genes including Connexin43 (Cx43). PA1 regulation of Cx43 expression depends on its interaction with JUN (AP-1 transcription factor), demonstrated by co-immunoprecipitation. Sertoli cell-specific conditional knockout, transcriptomics, CUT&TAG chromatin profiling, co-immunoprecipitation (PA1-JUN interaction), immunofluorescence localization Cell & bioscience High 35379345
2021 Bi-allelic missense variants in PAGR1 (c.274A>G; p.Ser92Gly) are associated with severe microcephaly and neurodevelopmental disorder in humans, and complete knockout of murine Pagr1a is embryonic lethal, establishing a required developmental role for this component of the MLL2/MLL3 histone methyltransferase complex. Exome and genome sequencing in two unrelated families, identification of shared homozygous variant; cited murine Pagr1a knockout lethality data American journal of medical genetics. Part A Medium 34585832

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1992 Cloning, expression, and nucleotide sequence of genes involved in production of pediocin PA-1, and bacteriocin from Pediococcus acidilactici PAC1.0. Applied and environmental microbiology 227 1514784
1993 Pediocin PA-1, a bacteriocin from Pediococcus acidilactici PAC1.0, forms hydrophilic pores in the cytoplasmic membrane of target cells. Applied and environmental microbiology 181 8285666
2002 Pediocin PA-1, a wide-spectrum bacteriocin from lactic acid bacteria. Critical reviews in food science and nutrition 148 11934133
1984 An activated rasN gene: detected in late but not early passage human PA1 teratocarcinoma cells. Science (New York, N.Y.) 141 6740333
1985 Embryonal lactosaminoglycan. The structure of branched lactosaminoglycans with novel disialosyl (sialyl alpha 2----9 sialyl) terminals isolated from PA1 human embryonal carcinoma cells. The Journal of biological chemistry 99 3997842
2019 Use of rare-earth elements in the phyllosphere colonizer Methylobacterium extorquens PA1. Molecular microbiology 91 30653750
2017 Chitin and chitosan preparation from shrimp shells Penaeus monodon and its human ovarian cancer cell line, PA-1. International journal of biological macromolecules 82 28923565
2019 Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1 cell line. Chemico-biological interactions 77 30639267
2002 Replacement of trifluoroacetic acid with HCl in the hydrophobic purification steps of pediocin PA-1: a structural effect. Applied and environmental microbiology 77 12324323
1997 Functional characterization of pediocin PA-1 binding to liposomes in the absence of a protein receptor and its relationship to a predicted tertiary structure. Applied and environmental microbiology 73 9023932
2017 Black phosphorus quantum dot based novel siRNA delivery systems in human pluripotent teratoma PA-1 cells. Journal of materials chemistry. B 71 32264082
2006 Applications of lipopolysaccharide derived from Pantoea agglomerans (IP-PA1) for health care based on macrophage network theory. Journal of bioscience and bioengineering 69 17270712
1992 Structural analysis of the linkage region oligosaccharides and unsaturated disaccharides from chondroitin sulfate using CarboPac PA1. The Journal of biological chemistry 67 1551866
1998 The bactericidal activity of pediocin PA-1 is specifically inhibited by a 15-mer fragment that spans the bacteriocin from the center toward the C terminus. Applied and environmental microbiology 63 9835610
1992 Polyaxonal amacrine cells of rabbit retina: morphology and stratification of PA1 cells. The Journal of comparative neurology 62 1577992
2007 In vitro inhibition activity of nisin A, nisin Z, pediocin PA-1 and antibiotics against common intestinal bacteria. Letters in applied microbiology 59 17718835
1976 The effects of purified mitogenic proteins (Pa-1 and Pa-2) from pokeweed on human T and B lymphocytes in vitro. Clinical and experimental immunology 58 1087210
2003 Differences in susceptibility of Listeria monocytogenes strains to sakacin P, sakacin A, pediocin PA-1, and nisin. Applied and environmental microbiology 57 12902226
1999 Enhanced production of pediocin PA-1 and coproduction of nisin and pediocin PA-1 by Lactococcus lactis. Applied and environmental microbiology 54 10508073
1998 Production of pediocin PA-1 by Lactococcus lactis using the lactococcin A secretory apparatus. Applied and environmental microbiology 50 9501421
2000 Heterologous coproduction of enterocin A and pediocin PA-1 by Lactococcus lactis: detection by specific peptide-directed antibodies. Applied and environmental microbiology 49 10919819
1995 Expression of lactococcin A and pediocin PA-1 in heterologous hosts. Letters in applied microbiology 45 7576505
1997 Interactions of nisin and pediocin PA-1 with closely related lactic acid bacteria that manifest over 100-fold differences in bacteriocin sensitivity. Applied and environmental microbiology 40 9293015
2021 Structural Basis of Pore Formation in the Mannose Phosphotransferase System by Pediocin PA-1. Applied and environmental microbiology 39 34851716
2015 Inhibition of marine Vibrio sp. by pyoverdine from Pseudomonas aeruginosa PA1. Journal of hazardous materials 39 26476308
1992 Polyaxonal amacrine cells of rabbit retina: size and distribution of PA1 cells. The Journal of comparative neurology 39 1374437
2017 Controlled functional expression of the bacteriocins pediocin PA-1 and bactofencin A in Escherichia coli. Scientific reports 38 28596555
2001 Characterization of the biologic activities of a recombinant human zona pellucida protein 3 expressed in human ovarian teratocarcinoma (PA-1) cells. American journal of obstetrics and gynecology 37 11303190
2016 Melatonin Suppresses the Growth of Ovarian Cancer Cell Lines (OVCAR-429 and PA-1) and Potentiates the Effect of G1 Arrest by Targeting CDKs. International journal of molecular sciences 35 26840297
2008 Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei. Journal of cancer research and clinical oncology 35 18202854
2005 Production of pediocin PA-1 in the methylotrophic yeast Pichia pastoris reveals unexpected inhibition of its biological activity due to the presence of collagen-like material. Protein expression and purification 35 16023368
1991 Identification of a retinoic acid-inducible endogenous retroviral transcript in the human teratocarcinoma-derived cell line PA-1. Journal of virology 34 1920638
2000 Gene-modified PA1-STK cells home to tumor sites in patients with malignant pleural mesothelioma. The Annals of thoracic surgery 33 10969653
1993 Molecular analysis of the rolling-circle replicating plasmid pA1 of Lactobacillus plantarum A112. Applied and environmental microbiology 33 8439153
2013 MicroRNA-21 promotes the ovarian teratocarcinoma PA1 cell line by sustaining cancer stem/progenitor populations in vitro. Stem cell research & therapy 32 23890123
2016 A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & development 31 26744420
1999 Differential response to exogenous and endogenous activin in a human ovarian teratocarcinoma-derived cell line (PA-1): regulation by cell surface follistatin. Endocrinology 30 10342830
2012 Simple and rapid purification of pediocin PA-1 from Pediococcus pentosaceous NCDC 273 suitable for industrial application. Microbiological research 29 22277956
1997 Vegetable-Associated Pediococcus parvulus Produces Pediocin PA-1. Applied and environmental microbiology 29 16535615
2007 Production of active pediocin PA-1 in Escherichia coli using a thioredoxin gene fusion expression approach: cloning, expression, purification, and characterization. Canadian journal of microbiology 28 18026219
2006 Sequence and analysis of the 46.6-kb plasmid pA1 from Sphingomonas sp. A1 that corresponds to the typical IncP-1beta plasmid backbone without any accessory gene. Plasmid 28 16445980
1988 PA-1, a human cell model for multistage carcinogenesis: oncogenes and other factors. Anticancer research 28 3052262
2014 Genetic and phenotypic comparison of facultative methylotrophy between Methylobacterium extorquens strains PA1 and AM1. PloS one 27 25232997
2014 Methylamine utilization via the N-methylglutamate pathway in Methylobacterium extorquens PA1 involves a novel flow of carbon through C1 assimilation and dissimilation pathways. Journal of bacteriology 26 25225269
1998 Generation of polyclonal antibodies of predetermined specificity against pediocin PA-1. Applied and environmental microbiology 25 9797320
1994 Suppression of tumorigenicity in human teratocarcinoma cell line PA-1 by introduction of chromosome 4. Cancer research 25 8168081
2015 The Pediocin PA-1 Accessory Protein Ensures Correct Disulfide Bond Formation in the Antimicrobial Peptide Pediocin PA-1. Biochemistry 24 25961806
1996 A two-site monoclonal antibody immunoradiometric assay for human follistatin: secretion by a human ovarian teratocarcinoma-derived cell line (PA-1). The Journal of clinical endocrinology and metabolism 24 8636347
2022 An oxidation resistant pediocin PA-1 derivative and penocin A display effective anti-Listeria activity in a model human gut environment. Gut microbes 22 35104196
2001 Production of biosurfactant from a new and promising strain of Pseudomonas aeruginosa PA1. Applied biochemistry and biotechnology 22 11963874
2019 Mapping the H2 resistance effective against Globodera pallida pathotype Pa1 in tetraploid potato. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 21 30666393
2006 Expression and purification of a fusion-typed pediocin PA-1 in Escherichia coli and recovery of biologically active pediocin PA-1. International journal of food microbiology 21 16403586
2016 Mitotic phosphorylation of SOX2 mediated by Aurora kinase A is critical for the stem-cell like cell maintenance in PA-1 cells. Cell cycle (Georgetown, Tex.) 20 27249336
2012 PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation. The Journal of biological chemistry 20 23161582
2007 Development of innovative pediocin PA-1 by DNA shuffling among class IIa bacteriocins. Applied and environmental microbiology 20 17601819
1992 The effect of retinoic acid on chemosensitivity of PA-1 human teratocarcinoma cells and its modulation by an activated N-ras oncogene. International journal of cancer 20 1376303
2020 MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ. Molecular and cellular biology 19 32601106
2016 Design of antibacterial biointerfaces by surface modification of poly (ε-caprolactone) with fusion protein containing hydrophobin and PA-1. Colloids and surfaces. B, Biointerfaces 19 28027492
2013 Characterization of leucocin B-KM432Bz from Leuconostoc pseudomesenteroides isolated from boza, and comparison of its efficiency to pediocin PA-1. PloS one 18 23936441
2011 Fusion expression of pedA gene to obtain biologically active pediocin PA-1 in Escherichia coli. Journal of Zhejiang University. Science. B 18 21194188
2011 Mutational analysis of residues in the helical region of the class IIa bacteriocin pediocin PA-1. Applied and environmental microbiology 18 21257813
2005 Secretion of recombinant pediocin PA-1 by Bifidobacterium longum, using the signal sequence for bifidobacterial alpha-amylase. Applied and environmental microbiology 18 16151166
2018 Design, Synthesis, and Biological Evaluation of 68Ga-DOTA-PA1 for Lung Cancer: A Novel PET Tracer for Multiple Somatostatin Receptor Imaging. Molecular pharmaceutics 17 29278911
2012 Sclerotium rolfsii lectin inhibits proliferation and induces apoptosis in human ovarian cancer cell line PA-1. Cell proliferation 17 22805123
2020 Synergistic inhibition mechanism of pediocin PA-1 and L-lactic acid against Aeromonas hydrophila. Biochimica et biophysica acta. Biomembranes 16 32428447
2014 PA-1, a novel synthesized pyrrolizidine alkaloid, inhibits the growth of Escherichia coli and Staphylococcus aureus by damaging the cell membrane. The Journal of antibiotics 16 24894184
2012 Rhamnolipid production: effect of oxidative stress on virulence factors and proteome of Pseudomonas aeruginosa PA1. Applied microbiology and biotechnology 16 22782250
2023 CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin. Nucleic acids research 15 37702151
2006 Identification and partial characterization of soluble and membrane-bound KDN(deaminoneuraminic acid)-glycoproteins in human ovarian teratocarcinoma PA-1, and enhanced expression of free and bound KDN in cells cultured in mannose-rich media. Glycoconjugate journal 15 16897181
2021 Functional diversity of isoprenoid lipids in Methylobacterium extorquens PA1. Molecular microbiology 14 34387371
2020 Application of yeast surface display system in expression of recombinant pediocin PA-1 in Saccharomyces cerevisiae. Folia microbiologica 14 32578013
1991 Modulation of differentiation in PA-1 human teratocarcinoma cells after N-ras oncogene-induced tumorigenicity. Oncogene 14 1681491
2007 Chimeras of mature pediocin PA-1 fused to the signal peptide of enterocin P permits the cloning, production, and expression of pediocin PA-1 in Lactococcus lactis. Journal of food protection 13 18095432
2016 Genomic analyses of multidrug resistant Pseudomonas aeruginosa PA1 resequenced by single-molecule real-time sequencing. Bioscience reports 12 27765811
2003 Binding of pediocin PA-1 with anionic lipid induces model membrane destabilization. Applied and environmental microbiology 12 14602640
2015 Improvement of Antimicrobial Activity of Pediocin PA-1 by Site-directed Mutagenesis in C-terminal Domain. Protein and peptide letters 11 26299998
2012 In situ production of pediocin PA-1 like bacteriocin by different genera of lactic acid bacteria in soymilk fermentation and evaluation of sensory properties of the fermented soy curd. Journal of food science and technology 11 26396327
1999 Antibodies to a synthetic 1-9-N-terminal amino acid fragment of mature pediocin PA-1: sensitivity and specificity for pediocin PA-1 and cross-reactivity against Class IIa bacteriocins. Microbiology (Reading, England) 11 10537199
2022 PA1 participates in the maintenance of blood-testis barrier integrity via cooperation with JUN in the Sertoli cells of mice. Cell & bioscience 10 35379345
2022 Role of EPS in mitigation of plant abiotic stress: The case of Methylobacterium extorquens PA1. Carbohydrate polymers 10 35989007
2021 Pediocin PA-1 production by Pediococcus pentosaceus ET34 using non-detoxified hemicellulose hydrolysate obtained from hydrothermal pretreatment of sugarcane bagasse. Bioresource technology 10 34315131
1993 Release of soluble TNF/LT receptors from a human ovarian tumor cell line (PA-1) by stimulation with cytokines in vitro. Lymphokine and cytokine research 10 8218597
2024 Molecular Dynamic Study on the Structure and Thermal Stability of Mutant Pediocin PA-1 Peptides Engineered with Cysteine Substitutions. Probiotics and antimicrobial proteins 9 38424320
2023 Efficacy of Penicillium limosum Strain AK-7 Derived Bioactive Metabolites on Antimicrobial, Antioxidant, and Anticancer Activity against Human Ovarian Teratocarcinoma (PA-1) Cell Line. Microorganisms 9 37894138
2018 Genomic analysis of the Phalaenopsis pathogen Dickeya sp. PA1, representing the emerging species Dickeya fangzhongdai. BMC genomics 9 30373513
2008 Immunity gene pedB enhances production of pediocin PA-1 in naturally resistant Lactococcus lactis strains. Journal of dairy science 9 18565917
2007 Development and potential use of a monoclonal antibody to the lipopolysaccharide of Pantoea agglomerans (IP-PA1). Anticancer research 9 17970031
2021 Inhibition of Proliferation in Ovarian Cancer Cell Line (PA-1) by the Action of Green Compound "Betanin". Applied biochemistry and biotechnology 8 34762269
2013 Mutational analysis of positively charged residues in the N-terminal region of the class IIa bacteriocin pediocin PA-1. Letters in applied microbiology 8 24261867
2024 Glycine betaine metabolism is enabled in Methylorubrum extorquens PA1 by alterations to dimethylglycine dehydrogenase. Applied and environmental microbiology 7 38534142
2021 Tilianin inhibits the human ovarian cancer (PA-1) cell proliferation via blocking cell cycle, inducing apoptosis and inhibiting JAK2/STAT3 signaling pathway. Saudi journal of biological sciences 7 34466064
2021 Exploring the cytotoxic mechanisms of Pediocin PA-1 towards HeLa and HT29 cells by comparison to known bacteriocins: Microcin E492, enterocin heterodimer and Divercin V41. PloS one 7 34473709
2021 Bi-allelic PAGR1 variants are associated with microcephaly and a severe neurodevelopmental disorder: Genetic evidence from two families. American journal of medical genetics. Part A 7 34585832
1999 Cytogenetic characteristics and p53 gene status of human teratocarcinoma PA-1 cells in 407-445 passages. International journal of molecular medicine 7 10567668
2017 Correlative Studies Unravelling the Possible Mechanism of Cell Death in Tideglusib-Treated Human Ovarian Teratocarcinoma-Derived PA-1 Cells. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 6 29431064
2012 Detection of mobile genetic elements in pediocin PA-1 like producing lactic acid bacteria. Journal of basic microbiology 6 22915312
2010 Heterologous production of pediocin PA-1 in Lactobacillus reuteri. Journal of microbiology and biotechnology 6 20798585
1999 Maintenance of near-diploid karyotype of PA-1 human ovarian teratocarcinoma cells due to death of polyploid cells by chromosome fragmentation/pulverization. International journal of molecular medicine 6 10425281
1979 Kinetics of B-lymphocytes stimulation by pokeweed Pa-1 mitogen and bacterial lipopolysaccharide. Immunology 6 315363
2005 The human ovarian teratocarcinoma cell line PA-1 demonstrates a single translocation: analysis with fluorescence in situ hybridization, spectral karyotyping, and bacterial artificial chromosome microarray. Cancer genetics and cytogenetics 5 16080959

Missed literature

Know a paper Affinage missed for PAGR1? Flag it for the maintainers and the community.

No submissions yet.