- Length
- 889 aa
- Mass
- 97.7 kDa
- Annotated
- 2026-06-14
58 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 58 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2005 | PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. | The EMBO journal | 492 | 15692567 |
| 2008 | The subcellular distribution of calnexin is mediated by PACS-2. | Molecular biology of the cell | 188 | 18417615 |
| 2014 | miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2. | RNA biology | 108 | 24646523 |
| 2022 | PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy. | Diabetes | 85 | 35133431 |
| 2020 | PACS-2: A key regulator of mitochondria-associated membranes (MAMs). | Pharmacological research | 78 | 32673704 |
| 2019 | The Multifunctional Sorting Protein PACS-2 Controls Mitophagosome Formation in Human Vascular Smooth Muscle Cells through Mitochondria-ER Contact Sites. | Cells | 75 | 31242668 |
| 2008 | HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice. | The Journal of biological chemistry | 73 | 18296443 |
| 2014 | The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest. | Cell reports | 69 | 25159152 |
| 2009 | Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. | Molecular cell | 67 | 19481529 |
| 2001 | Effect of postoperative atrial fibrillation on length of stay after cardiac surgery (The Postoperative Atrial Fibrillation in Cardiac Surgery study [PACS(2)]. | The American journal of cardiology | 65 | 11274944 |
| 2019 | PACS2 is required for ox-LDL-induced endothelial cell apoptosis by regulating mitochondria-associated ER membrane formation and mitochondrial Ca2+ elevation. | Experimental cell research | 59 | 30970236 |
| 2012 | An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I. | Molecular biology of the cell | 58 | 22496420 |
| 2018 | A Recurrent De Novo PACS2 Heterozygous Missense Variant Causes Neonatal-Onset Developmental Epileptic Encephalopathy, Facial Dysmorphism, and Cerebellar Dysgenesis. | American journal of human genetics | 57 | 29656858 |
| 2021 | PACS-2 attenuates diabetic kidney disease via the enhancement of mitochondria-associated endoplasmic reticulum membrane formation. | Cell death & disease | 54 | 34836936 |
| 2012 | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2). | The Journal of biological chemistry | 47 | 22645134 |
| 2015 | The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17. | Nature communications | 45 | 26108729 |
| 2018 | An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity. | Molecular cell | 42 | 30415949 |
| 2024 | PACS2/CPT1A/DHODH signaling promotes cardiomyocyte ferroptosis in diabetic cardiomyopathy. | Cardiovascular diabetology | 31 | 39633391 |
| 2016 | PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. | Cell death and differentiation | 30 | 26943323 |
| 2022 | Ferulic acid attenuates high glucose-induced MAM alterations via PACS2/IP3R2/FUNDC1/VDAC1 pathway activating proapoptotic proteins and ameliorates cardiomyopathy in diabetic rats. | International journal of cardiology | 27 | 36481261 |
| 2014 | Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. | PloS one | 27 | 24633224 |
| 2022 | PACS2-TRPV1 axis is required for ER-mitochondrial tethering during ER stress and lung fibrosis. | Cellular and molecular life sciences : CMLS | 26 | 35212819 |
| 2022 | PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease. | Molecular medicine (Cambridge, Mass.) | 26 | 36138342 |
| 2023 | PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy. | Cell death & disease | 24 | 37794057 |
| 2019 | Expanding the clinical spectrum associated with PACS2 mutations. | Clinical genetics | 19 | 30684285 |
| 2022 | AKT/PACS2 Participates in Renal Vascular Hyperpermeability by Regulating Endothelial Fatty Acid Oxidation in Diabetic Mice. | Frontiers in pharmacology | 13 | 35865947 |
| 2023 | Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia. | iScience | 11 | 36968068 |
| 2020 | Coloboma may be a shared feature in a spectrum of disorders caused by mutations in the WDR37-PACS1-PACS2 axis. | American journal of medical genetics. Part A | 11 | 33369122 |
| 2024 | Renal denervation improves mitochondrial oxidative stress and cardiac hypertrophy through inactivating SP1/BACH1-PACS2 signaling. | International immunopharmacology | 10 | 39173402 |
| 2022 | The Phosphofurin Acidic Cluster Sorting Protein 2 (PACS-2) E209K Mutation Responsible for PACS-2 Syndrome Increases Susceptibility to Apoptosis. | ACS omega | 9 | 36188273 |
| 2022 | First reported case of an inherited PACS2 pathogenic variant with variable expression. | Epileptic disorders : international epilepsy journal with videotape | 7 | 35770754 |
| 2019 | MAP‑1B, PACS‑2 and AHCYL1 are regulated by miR‑34A/B/C and miR‑449 in neuroplasticity following traumatic spinal cord injury in rats: Preliminary explorative results from microarray data. | Molecular medicine reports | 7 | 31432119 |
| 2021 | [Early infantile epileptic encephalopathy caused by PACS2 gene variation: three cases report and literature review]. | Zhonghua er ke za zhi = Chinese journal of pediatrics | 6 | 34405643 |
| 2025 | PACS2 initiates foam cell formation in macrophages through the ROS-PPARγ-CD36 positive feedback loop. | Biochemical pharmacology | 5 | 40653022 |
| 2022 | Knockdown of circ_0002194 protects against oxidized low-density lipoprotein-induced cell damage via the regulation of the miR-637/PACS2 axis in human vascular endothelial cells. | Interactive cardiovascular and thoracic surgery | 5 | 35951762 |
| 2021 | Vein of Galen aneurysm, dilated cardiomyopathy, and slender habitus in a patient with a recurrent pathogenic variant in PACS2. | American journal of medical genetics. Part A | 5 | 34894068 |
| 2017 | Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the ApcMin model of colorectal cancer. | Oncotarget | 5 | 29312533 |
| 2024 | PACS-1 variant protein is aberrantly localized in Caenorhabditis elegans model of PACS1/PACS2 syndromes. | Genetics | 4 | 39031646 |
| 2025 | PACS2/PKCα/NOX4 pathway damaged the renal vascular endothelial barrier by promoting ROS production in diabetic nephropathy mice. | Molecular and cellular biochemistry | 3 | 40775117 |
| 2023 | Long-Term Outcome of Neonatal Seizure with PACS2 Mutation: Case Series and Literature Review. | Children (Basel, Switzerland) | 3 | 37189870 |
| 2025 | PACS-2 Mitigates NPSC Apoptosis and Intervertebral Disc Degeneration by Preserving MAM Integrity via the SP1/LRRK2/Mfn2 Axis. | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | 2 | 41190767 |
| 2022 | First Report of Mexican Patients with PACS1-Related Neurodevelopmental Disorder and Review of the PACS1-, PACS2-, and WDR37-Related Ophthalmological Manifestations. | Molecular syndromology | 2 | 37064331 |
| 2025 | AI-Based Facial Phenotyping Supports a Shared Molecular Axis in PACS1-, PACS2-, and WDR37-Related Syndromes. | International journal of molecular sciences | 1 | 40869285 |
| 2024 | A missense variant in the PACS2 gene cause Epileptic Encephalopathy and seizures in Saudi family. | Pakistan journal of medical sciences | 1 | 38545008 |
| 2024 | The PACS-2 protein and trafficking motifs in CCHFV Gn and Gc cytoplasmic domains govern CCHFV assembly. | Emerging microbes & infections | 1 | 38661085 |
| 2024 | PACS2, PACS1, and VACTERL: A Clinical Overlap. | Molecular syndromology | 1 | 39911171 |
| 2023 | PACS2 pathogenic variant associated with malformation of cortical development and epilepsy. | Epileptic disorders : international epilepsy journal with videotape | 1 | 38031819 |
| 2021 | [Clinical and genetic analysis of PACS2 gene variant in two child patients with developmental and epileptic encephalopathy 66]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics | 1 | 34625934 |
| 2026 | MiR-499-5P/PACS2/TRPV1 Axis Maintains Mitochondrial Homeostasis and Left Ventricular Function after Extreme Cold Stress. | Journal of cardiovascular translational research | 0 | 41644764 |
| 2026 | PACS2 deficiency ameliorates hepatic steatosis via inhibition of the JNK signaling pathway in diabetic mice. | Biochemical pharmacology | 0 | 41687826 |
| 2026 | Quercetin Alleviates Endothelial Dysfunction in Atherosclerosis by Inhibiting Ferroptosis Through PACS2/HMOX-1 Pathway. | The American journal of Chinese medicine | 0 | 41692703 |
| 2026 | Macrophage FTO deficiency accelerates atherosclerosis via PACS2-mediated activation of the PPARγ lipid signaling pathway. | Journal of translational medicine | 0 | 41917949 |
| 2026 | Crebanine attenuates copper neurotoxicity via PACS-2 upregulation and TXNIP/TRPV1 axis suppression. | Neurotoxicology | 0 | 41962777 |
| 2026 | PACS2 Alleviates Sepsis-Induced Myopathy by Activating ERK-MAPK Signalling Pathway to Suppress ER-Phagy. | Journal of cachexia, sarcopenia and muscle | 0 | 42104568 |
| 2026 | Silencing PACS2 attenuates cardiac hypertrophy by inhibiting ferroptosis via activating SIRT1. | Journal of molecular and cellular cardiology | 0 | 42140577 |
| 2024 | Characteristics of Developmental and Epileptic Encephalopathy Associated with PACS2 p.Glu209Lys Pathogenic Variant-Our Experience and Systematic Review of the Literature. | Biomolecules | 0 | 38540691 |
| 2024 | PACS-1 variant protein is aberrantly localized in C. elegans model of PACS1/PACS2 syndromes. | bioRxiv : the preprint server for biology | 0 | 38712144 |
| 2024 | Understanding PACS2 syndrome's pathomechanism by studying E209K and E211K mutations. | Mammalian genome : official journal of the International Mammalian Genome Society | 0 | 39738582 |
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