Affinage

Showing NGFR — P75NTR is a alias.

NGFR

Tumor necrosis factor receptor superfamily member 16 · UniProt P08138

Length
427 aa
Mass
45.2 kDa
Annotated
2026-06-10
100 papers in source corpus 30 papers cited in narrative 30 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NGFR (p75NTR), a TNF-receptor superfamily neurotrophin receptor, integrates neurotrophin signaling by physically partnering with the Trk receptor tyrosine kinases TrkA, TrkB, and TrkC through both its extracellular and intracellular domains, an interaction dependent on Trk autophosphorylation that sharpens ligand specificity of Trk activation (PMID:9927421). The receptor binds the unprocessed precursor proNGF in a 2:2 symmetric mode distinct from mature NGF, and calcium promotes assembly of a stable proNGF–sortilin–p75NTR ternary complex that drives pro-apoptotic signaling (PMID:20036257). p75NTR couples to opposing fates depending on context: it triggers apoptosis via JNK-dependent phosphorylation and oligomerization of Bad, cytochrome c release, and caspase-9/6/3 activation (PMID:14673001), yet upon NGF stimulation it also undergoes Trk/MEK-Erk-driven alpha- and gamma-secretase cleavage that releases an intracellular domain required for neurotrophin-dependent Akt activation and growth arrest (PMID:20530577). In the nervous system the receptor controls neuronal excitability through a proBDNF-activated Rac1/PIP2 cascade (PMID:26134656) and contributes to pathological tau phosphorylation via AKT/GSK3β (PMID:29867188). Beyond neurons, NGFR is a major driver in melanoma and other cancers, where it promotes immune evasion by upregulating stearoyl-CoA desaturase to escape NK-cell killing (PMID:36638181), enhances T-cell and BRAF/MEK-inhibitor resistance through BDNF induction (PMID:32770055), and spreads via NGFR-enriched extracellular vesicles that activate ERK/NF-κB/ICAM-1 in lymphatic endothelium to promote metastasis (PMID:34957415). It also regulates stem-cell differentiation, both inhibiting multilineage mesenchymal differentiation (PMID:21142793) and positively driving osteogenic differentiation through PI3K/Akt/β-catenin (PMID:32215984).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1996 Medium

    Established that NGF signaling engages an enzymatic activity physically associated with p75NTR, indicating the receptor is not merely a passive binding protein but a signaling platform.

    Evidence Co-IP kinase assay and cytoplasmic-domain deletion analysis in dorsal root ganglion and PC12 cells

    PMID:8698038

    Open questions at the time
    • The identity of the associated 120/104 kDa kinase was not established
    • Whether the kinase association is direct or bridged by another protein is unresolved
  2. 1999 High

    Defined the physical basis for crosstalk between p75NTR and the Trk family, showing p75NTR directly modulates Trk ligand selectivity.

    Evidence Reciprocal Co-IP with deletion constructs and kinase inhibition across TrkA/B/C in transfected cells

    PMID:9927421

    Open questions at the time
    • Stoichiometry and structural interface of the Trk–p75NTR complex not defined
    • Whether the interaction is constitutive or ligand-induced in vivo unclear
  3. 2003 High

    Elucidated the apoptotic effector arm of p75NTR, linking it through JNK to the intrinsic mitochondrial cell-death machinery.

    Evidence Overexpression plus dominant-negative and RNAi loss-of-function with biochemical JNK/cytochrome c/caspase readouts in multiple cell types

    PMID:14673001

    Open questions at the time
    • How ligand engagement activates JNK upstream of Bad is not defined
    • Does not address how the apoptotic versus survival decision is selected
  4. 2009 High

    Resolved the structural distinction between proNGF and mature NGF recognition, explaining how the precursor selectively drives the pro-apoptotic co-receptor complex.

    Evidence X-ray crystallography of proNGF–p75NTR, SPR, and cell-based ternary complex assays

    PMID:20036257

    Open questions at the time
    • Structure of the full proNGF–sortilin–p75NTR ternary assembly not solved
    • Role of the disordered pro region in signaling not defined
  5. 2010 High

    Identified regulated intramembrane proteolysis as the mechanism converting p75NTR into a soluble intracellular signaling effector that potentiates Akt and growth arrest.

    Evidence Secretase and MEK-Erk inhibition, p75NTR-knockout neurons, and rescue with cleavage-resistant vs intact constructs in PC12 cells

    PMID:20530577

    Open questions at the time
    • Direct molecular targets of the released ICD not identified
    • How the ICD potentiates Akt mechanistically unresolved
  6. 2015 Medium

    Clarified the oligomeric state of the receptor, showing trimers predominate but are dispensable for acute morphological signaling carried by monomers.

    Evidence Biochemical oligomerization assays in vitro and in mouse brain plus growth cone retraction functional assay

    PMID:26311773

    Open questions at the time
    • Which signaling outputs require trimers versus monomers is not fully mapped
    • Single lab, no orthogonal structural validation
  7. 2015 High

    Connected p75NTR to control of cortical neuron excitability through a defined Rac1/PIP2 signaling cascade activated by proBDNF.

    Evidence Electrophysiology with constitutive, conditional, and inducible p75NTR deletion plus antibody blockade and pharmacology

    PMID:26134656

    Open questions at the time
    • Direct molecular link from p75NTR to Rac1 not defined
    • Whether sortilin participates in this pathway not tested
  8. 2020 Medium

    Defined opposing roles of p75NTR in stem-cell fate, demonstrating it drives osteogenic differentiation via PI3K/Akt/β-catenin in vivo.

    Evidence p75NTR-knockout mice, micro-CT, and PI3K agonist/antagonist epistasis in ectomesenchymal stem cells

    PMID:32215984

    Open questions at the time
    • Reconciliation with reports of p75NTR inhibiting multilineage differentiation not addressed
    • How p75NTR activates PI3K upstream is unclear
  9. 2021 High

    Revealed a non-cell-autonomous metastatic mechanism in which NGFR cargo in extracellular vesicles reprograms lymphatic endothelium.

    Evidence sEV isolation with NGFR ablation/inhibition and in vivo lymphangiogenesis/metastasis models with ERK/NF-κB/ICAM-1 readouts

    PMID:34957415

    Open questions at the time
    • How NGFR in sEVs activates recipient-cell ERK/NF-κB mechanistically not defined
    • Receptor for NGFR-bearing sEVs on endothelial cells not identified
  10. 2023 High

    Established NGFR as a driver of NK-cell immune evasion in melanoma through metabolic rewiring via stearoyl-CoA desaturase.

    Evidence NK cytotoxicity assays with NGFR overexpression and SCD pharmacological/siRNA inhibition in vitro and in metastasis models

    PMID:36638181

    Open questions at the time
    • How NGFR transcriptionally controls SCD and NK ligands is not defined
    • Whether SCD-driven lipid changes act on NK ligands or membrane properties unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single receptor selects between pro-apoptotic, pro-survival, differentiation, and oncogenic immune-evasion outputs across cell types remains the central unresolved question.
  • No unified model of how co-receptor (sortilin, Trk), oligomeric state, and proteolysis jointly determine output
  • Direct intracellular effectors of the cleaved ICD remain unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0048018 receptor ligand activity 1
Localization
GO:0005768 endosome 1 GO:0005829 cytosol 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 2 R-HSA-168256 Immune System 2 R-HSA-5357801 Programmed Cell Death 1
Partners
SC1SORCS3SORTILINTRKATRKBTRKC
Complex memberships
proNGF–sortilin–p75NTR ternary complex

Evidence

Reading pass · 30 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 p75NTR physically interacts with TrkA, TrkB, and TrkC receptor tyrosine kinases (but not EGFR), as demonstrated by co-immunoprecipitation in transfected cells. Both extracellular and intracellular domains of TrkB and p75NTR contribute to this interaction. Blocking TrkB autophosphorylation substantially reduced interactions involving the intracellular domains. Co-expression of p75NTR with TrkB increased specificity of TrkB activation by BDNF relative to NT-3 and NT-4/5. Co-immunoprecipitation, deletion construct analysis, kinase inhibition The EMBO journal High 9927421
1996 NGF activates a protein kinase (120 and 104 kDa proteins) directly associated with p75(NGFR), co-immunoprecipitated from dorsal root ganglion and PC12 cells. TrkA activation was necessary to elicit p75(NGFR)-associated kinase activity. A 43 amino acid region in the cytoplasmic domain of p75(NGFR) was responsible for accelerating kinase activation at low NGF concentrations, even when NGF binding to p75(NGFR) was not required. Co-immunoprecipitation, kinase assay, deletion analysis The EMBO journal Medium 8698038
2003 p75NTR overexpression in primary cortical neurons, PC12 cells, and glioma cells activates JNK, causes cytosolic cytochrome c accumulation, and activates caspases 9, 6, and 3. p75NTR-dependent JNK activation leads to phosphorylation and oligomerization of the BH3-domain-only family member Bad. Loss-of-function using Bad dominant negatives or RNA interference demonstrated a requirement for Bad in p75NTR-induced apoptosis. Overexpression, loss-of-function (dominant negative, RNAi), biochemical assays for JNK activation, cytochrome c release, caspase activity The Journal of neuroscience High 14673001
2009 Crystal structure of proNGF complexed with p75NTR resolved at 3.75 Å reveals a 2:2 symmetric binding mode, contrasting with the asymmetric structure of mature NGF bound to p75NTR. The pro regions of proNGF are mostly disordered and two hairpin loops (loop 2) at the top of the NGF dimer undergo conformational changes compared to mature neurotrophin structures. Surface plasmon resonance and cell-based assays showed calcium ions promote formation of a stable ternary complex of proNGF-sortilin-p75NTR. X-ray crystallography, surface plasmon resonance, cell-based binding assays Journal of molecular biology High 20036257
2010 In PC12 cells, NGF induces rapid alpha-secretase- and gamma-secretase-dependent cleavage of p75NTR, releasing the intracellular domain (ICD) into the cytosol. This cleavage is mediated by Trk-dependent activation of MEK-Erk signaling and induction of alpha-secretase activity, and is independent of ligand binding to p75NTR. Neurons and PC12 cells lacking p75NTR show defects in neurotrophin-dependent Akt activation that are rescued by full-length p75NTR or the p75 ICD but not cleavage-resistant p75NTR. NGF-dependent growth arrest of PC12 cells requires p75NTR cleavage and ICD generation. Pharmacological inhibition of secretases, MEK-Erk pathway inhibition, p75NTR knockout neurons, rescue with full-length vs cleavage-resistant constructs, Akt activation assays Journal of cell science High 20530577
2015 p75NTR predominantly assembles as a trimer (with monomers and trimers coexisting at the cell surface), as determined by biochemical techniques in vitro and in mouse brain tissue. Trimers are not required for ligand-independent or ligand-dependent p75NTR activation in a growth cone retraction functional assay; monomers are capable of inducing acute morphological effects in neurons. Biochemical oligomerization assays (in vitro and mouse brain tissue), functional growth cone retraction assay The Journal of neuroscience Medium 26311773
2015 NMR spectroscopy of p75NTR transmembrane and intracellular domains in lipid-protein nanodiscs revealed high flexibility and disorder in the juxtamembrane chopper domain, resulting in motions of the death domain being uncoupled from the transmembrane helix. Neither intracellular domain demonstrated propensity to interact with the membrane or to self-associate under these conditions. Solution NMR spectroscopy in lipid-protein nanodiscs Biophysical journal Medium 26287629
2004 SC1 (Schwann cell factor 1), a p75NTR-interacting protein, acts as a transcriptional repressor requiring trichostatin A-sensitive HDAC activity (forming a complex with HDACs 1, 2, and 3). SC1 represses the cyclin E promoter, suggesting a mechanism for growth arrest. The zinc finger and PR domains are required for repressive activity, efficient block of BrdU incorporation, and nuclear localization. Gal4 tethering transcriptional assay, HDAC co-immunoprecipitation, promoter reporter assay, domain deletion analysis, BrdU incorporation The Journal of cell biology Medium 15051733
2006 IGF-1 receptor (IGF1-R) signaling, through IRS2, PIP3/Akt, and regulated by PTEN and p44 (short isoform of p53), controls the age-dependent switch from TrkA to p75NTR expression in human neuroblastoma lines and primary mouse neurons. This TrkA-to-p75NTR switch is accompanied by ceramide activation, BACE1 stabilization, and increased amyloid beta-peptide production. Signaling pathway manipulation (IGF1-R, PTEN, p44 transgenic mice), biochemical assays for ceramide, BACE1, and Abeta The EMBO journal Medium 16619032
2015 proBDNF activates p75NTR to suppress persistent firing and excitability of entorhinal cortex layer V pyramidal neurons via a Rac1-dependent and PIP2-dependent signaling cascade. proBDNF decreases cholinergic calcium responses in cortical neurons and affects carbachol-induced depletion of PIP2. Genetic deletion of p75NTR specifically in neurons or during adulthood enhances excitability and persistent firing. Electrophysiological recordings, p75NTR null mice, conditional/inducible p75NTR deletion, function-blocking antibodies, pharmacological probes The Journal of neuroscience High 26134656
2003 Osmotic swelling-induced cell swelling activates transcription of the p75NTR gene via a pathway requiring phospholipase C, protein kinase C, and nitric-oxide synthase activity, independent of de novo protein synthesis. Reporter gene assay, pharmacological inhibition of PLC, PKC, NOS, tonicity manipulation The Journal of biological chemistry Medium 12821676
2018 proNGF induces tau phosphorylation via p75NTR through the AKT/GSK3β pathway in vitro. Genetic reduction of p75NTR in P301L transgenic mice rescued memory deficits, alleviated tau hyperphosphorylation, and restored AKT/GSK3β pathway activity. In vitro proNGF treatment, p75NTR genetic reduction in transgenic mice, biochemical pathway analysis (AKT/GSK3β) Molecular psychiatry Medium 29867188
2008 Two Nogo-66-derived peptides (Pep4 and NEP1-40) that modulate NgR-mediated neurite outgrowth inhibition also prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons and protect spinal cord motor neurons after neonatal sciatic nerve axotomy, demonstrating that NgR antagonizes p75NTR-dependent motor neuron death. Cultured embryonic motor neuron survival assay, neonatal sciatic nerve axotomy in vivo Proceedings of the National Academy of Sciences of the United States of America Medium 18182498
2021 Melanoma-derived small extracellular vesicles (sEVs) enriched in NGFR spread through the lymphatic system and are taken up by lymphatic endothelial cells, inducing ERK kinase and NF-κB activation and ICAM-1 expression to enhance lymphangiogenesis and tumor cell adhesion. Ablation or inhibition of NGFR in sEVs reversed the lymphangiogenic phenotype and decreased lymph node metastasis in pre-clinical models. sEV isolation and characterization, NGFR ablation/inhibition in sEVs, in vivo murine lymphangiogenesis/metastasis models, signaling pathway analysis (ERK, NF-κB, ICAM-1) Nature cancer High 34957415
2017 In melanoma, CD271 (NGFR) plays a dual role in phenotype switching: the cleaved intracellular domain controls proliferation, while interaction of CD271 with TrkA modulates cell adhesiveness through dynamic regulation of cholesterol synthesis genes. CD271 expression manipulation, analysis of intracellular domain cleavage products, TrkA interaction studies, gene expression profiling of cholesterol synthesis genes Nature communications Medium 29215016
2016 CD271 knockdown in hypopharyngeal cancer cells completely suppressed tumor-forming capability, induced cell-cycle arrest in G0, suppressed ERK phosphorylation, and strongly upregulated CDKN1C. Double knockdown of CD271 and CDKN1C partially rescued cells from G0 arrest. Inhibition of CD271-RhoA signaling by TAT-Pep5 diminished in vitro migration capability. siRNA knockdown, in vivo/in vitro tumor formation assays, ERK phosphorylation assay, double knockdown epistasis, RhoA pathway inhibition Scientific reports Medium 27469492
2023 Induced expression of Ngfr in the hippocampus of APP/PS1dE9 mice suppressed reactive astrocyte marker Lipocalin-2 (Lcn2), which itself reduced neurogenesis in astroglia. Anti-neurogenic effects of Lcn2 were mediated by Slc22a17; blockage of Slc22a17 recapitulated the pro-neurogenic effect of Ngfr. Long-term Ngfr expression reduced amyloid plaques and tau phosphorylation. In vivo Ngfr overexpression, histological analysis, single-cell transcriptomics, spatial proteomics, functional knockdown of Lcn2 and Slc22a17 NPJ Regenerative medicine Medium 37429840
2022 SorCS3 co-localizes with and binds to p75NTR in GBM cells (confirmed by immunofluorescence and Co-IP), promoting endosomal trafficking of p75NTR to the lysosome for degradation, thereby reducing p75NTR protein levels and suppressing NGF/p75NTR-driven cell invasion and proliferation. Co-immunoprecipitation, immunofluorescence co-localization, endosomal trafficking assays, proliferation/invasion assays Cell death & disease Medium 35393432
2017 p75NTR is expressed on plasmacytoid dendritic cells (pDCs) and its activation modulates immune function through TLR9 signaling, involving differential phosphorylation of interferon regulatory factor 3 and 7. p75NTR activation of pDCs influenced allergen-specific T cell proliferation and cytokine secretion in an NGF concentration-dependent manner. p75NTR expression characterization on pDCs, TLR9 activation assays, IRF3/7 phosphorylation, T cell proliferation co-culture assays, ovalbumin-induced asthma mouse model Frontiers in immunology Medium 28861085
2020 NGFR expression in melanoma drives resistance to T cell attack and BRAF+MEK inhibitors. NGFRhi cells induce the neurotrophic factor BDNF, which contributes to T cell resistance. Pharmacologic NGFR inhibition restores tumor sensitivity to T cell attack in vitro and in melanoma xenografts. Chronic T cell exposure selection, BRAF+MEK inhibitor treatment, BDNF functional assays, pharmacological NGFR inhibition, melanoma xenograft models Nature communications Medium 32770055
2020 p75NTR knockout mice exhibit reduced alveolar bone mass. p75NTR positively regulates osteogenic differentiation of ectomesenchymal stem cells (EMSCs) via the PI3K/Akt/β-catenin pathway. The promotive effect of p75NTR overexpression was attenuated by PI3K inhibitor LY294002, and the inhibitory effect of p75NTR knockdown on Runx2 and Col1 expression was reversed by PI3K agonist 740Y-P. p75NTR knockout mice, micro-CT, RNA-sequencing, lentiviral p75NTR overexpression/knockdown, PI3K pathway pharmacological manipulation Cell proliferation Medium 32215984
2021 In denervated skeletal muscle, pro-BDNF and p75NTR are significantly upregulated, and JNK and NF-κB downstream pathways are activated along with muscle atrophy and inflammation. p75NTR inhibition using LM11A-31 significantly reduced JNK activation and inflammatory cytokines in denervated muscle. Skeletal muscle-specific BDNF knockout reduced pro-BDNF levels, JNK activation, and inflammation. Sciatic nerve denervation mouse model, p75NTR inhibitor (LM11A-31), skeletal muscle-specific BDNF KO, Western blot, tissue staining Life sciences Medium 34678261
2023 In denervated skeletal muscle, glial cells express Ngfr and are located near neuromuscular junctions close to Thy1/CD90-expressing cells, which provide the main cellular source of NGF post-denervation. Functional communication between these cells is mediated by NGF/NGFR, as recombinant NGF or co-culture with Thy1/CD90-expressing cells increased glial cell number ex vivo. scRNA-seq/snATAC-seq, sciatic nerve transection model, ex vivo co-culture, recombinant NGF treatment iScience Medium 37416457
2023 NGFR expression in melanoma cells leads to down-regulation of NK cell activating ligands and up-regulation of stearoyl-coenzyme A desaturase (SCD), protecting melanoma cells from NK cell-mediated killing. Pharmacological and siRNA-mediated inhibition of SCD reversed NGFR-induced NK cell evasion in vitro and in vivo. In vitro and in vivo NK cell cytotoxic assays, NGFR overexpression, SCD pharmacological inhibition, SCD siRNA knockdown, mouse metastasis model with adoptively transferred human NK cells Science advances High 36638181
2016 p75NTR in retinal glia and pericytes mediates ligand-dependent (proNGF) induction of inflammatory cytokines, disruption of the neuro-glia-vascular unit, promotion of blood-retina barrier breakdown, edema, and neuronal death in a streptozotocin mouse model of diabetic retinopathy. p75NTR-dependent inflammation leads to ischemia and pathological angiogenesis through Semaphorin 3A. Antagonists of p75NTR or proNGF suppressed each phase of pathology. Streptozotocin diabetic retinopathy mouse model, oxygen-induced retinopathy model, p75NTR and proNGF antagonists The Journal of neuroscience Medium 27559166
2011 CD271/p75NTR inhibits the differentiation of mesenchymal stem cells into osteogenic, adipogenic, chondrogenic, and myogenic lineages. CD271+ DDPSCs showed inhibited differentiation into osteoblasts and adipocytes compared to CD271- cells. Forced expression of CD271 in C3H10T1/2 cells (10T271) inhibited differentiation into all four lineages. FACS sorting of CD271+ subpopulations, forced CD271 overexpression in C3H10T1/2 cells, in vitro multilineage differentiation assays Stem cells and development Medium 21142793
2020 In valproic acid (VPA)-treated neuroblastoma cells, p75NTR and sortilin are upregulated via HDAC inhibition leading to decreased EZH2 and upregulation of transcription factor CASZ1, a positive regulator of p75NTR. VPA favored proNGF-induced p75NTR/sortilin interaction and enhanced JNK activation and apoptosis. Depletion of p75NTR or blocking proNGF/sortilin interaction (neurotensin) reduced apoptotic response. HDAC inhibitor treatment, EZH2/CASZ1 knockdown, p75NTR and sortilin knockdown, proNGF treatment, JNK activation assay, apoptosis assays Apoptosis Medium 32712736
2016 NGFR knockdown in murine OSCC cells suppressed tumor invasion and metastasis. NGF treatment of NGFR+ OSCC cells increased ESM1 (endocan) expression. ESM1 overexpression conferred an enhanced migratory, invasive, and metastatic phenotype. ESM1 shRNA knockdown in NGFR-overexpressing OSCC cells abrogated tumor growth kinetics and invasive/metastatic properties, placing ESM1 downstream of NGFR in regulating OSCC invasion. NGFR overexpression/knockdown, NGF stimulation, gene expression array, ESM1 overexpression, ESM1 shRNA knockdown, in vitro migration/invasion assays, in vivo metastasis model Oncotarget Medium 27683113
2014 Stable shRNA-mediated knockdown of CD271 in patient-derived melanoma cells abrogated tumor-initiating and colony-forming capacity. Genome-wide expression profiling linked CD271 to SOX10 and a neural crest stem cell (NCSC) signature, and connected CD271 expression to CD133. shRNA knockdown, in vivo tumor-initiating assay, genome-wide expression profiling, gene-set enrichment analysis PloS one Medium 24799129
2014 In human epidermis, CD271 overexpression provokes the switch of keratinocyte stem cells (KSCs) to transit-amplifying (TA) cells, while silencing CD271 induced TA cells to revert to a KSC phenotype (assessed by β1-integrin expression and increased clonogenic ability). CD271(+) TA cells expressed more survivin and keratin 15 and displayed higher proliferative capacity. CD271 overexpression, siRNA silencing, FACS sorting, clonogenic assay, skin equivalent models The Journal of investigative dermatology Medium 25330297

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature 580 20596026
1999 Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. The EMBO journal 365 9927421
2002 The many faces of p75NTR. Current opinion in neurobiology 269 12049931
2005 p75NTR--live or let die. Current opinion in neurobiology 268 15721744
2004 p75NTR is positively promiscuous: novel partners and new insights. Neuron 263 15157416
1997 Signalling through the neurotrophin receptor p75NTR. Current opinion in neurobiology 191 9232808
1997 p75NTR and apoptosis: Trk-dependent and Trk-independent effects. Trends in neurosciences 154 9223218
2017 ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs. Nature cell biology 152 29255171
2021 Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism. Nature cancer 150 34957415
2003 Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad. The Journal of neuroscience : the official journal of the Society for Neuroscience 135 14673001
1998 p75NTR: A study in contrasts. Cell death and differentiation 123 10200483
2015 CD271 as a marker to identify mesenchymal stem cells from diverse sources before culture. World journal of stem cells 120 25815130
2006 An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generation. The EMBO journal 110 16619032
2007 Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate. Cytokine & growth factor reviews 96 17531524
2007 A cell-biological model of p75NTR signaling. Journal of neurochemistry 95 17437539
2009 Molecular and structural insight into proNGF engagement of p75NTR and sortilin. Journal of molecular biology 89 20036257
2020 Reversal of pre-existing NGFR-driven tumor and immune therapy resistance. Nature communications 87 32770055
2023 Targeted Delivery of RGD-CD146+CD271+ Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood-Spinal Cord Barrier Repair after Spinal Cord Injury. ACS nano 84 37695238
2008 The function of p75NTR in glia. Trends in neurosciences 82 18199491
1998 p75NTR and the concept of cellular dependence: seeing how the other half die. Cell death and differentiation 80 10200485
2014 The nerve growth factor receptor CD271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells. PloS one 77 24799129
2017 low neurotrophin receptor CD271 regulates phenotype switching in melanoma. Nature communications 71 29215016
2003 Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR). Cytokine & growth factor reviews 71 12787561
2010 The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling. Journal of cell science 70 20530577
2011 CD271/p75(NTR) inhibits the differentiation of mesenchymal stem cells into osteogenic, adipogenic, chondrogenic, and myogenic lineages. Stem cells and development 69 21142793
2015 Potential Effect of CD271 on Human Mesenchymal Stromal Cell Proliferation and Differentiation. International journal of molecular sciences 66 26184166
2016 Antibody Therapy Targeting CD47 and CD271 Effectively Suppresses Melanoma Metastasis in Patient-Derived Xenografts. Cell reports 63 27477289
2013 CD271 defines a stem cell-like population in hypopharyngeal cancer. PloS one 59 23626764
2018 Low-affinity Nerve Growth Factor Receptor (CD271) Heterogeneous Expression in Adult and Fetal Mesenchymal Stromal Cells. Scientific reports 58 29915318
2016 p75NTR and Its Ligand ProNGF Activate Paracrine Mechanisms Etiological to the Vascular, Inflammatory, and Neurodegenerative Pathologies of Diabetic Retinopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience 58 27559166
2015 Single CD271 marker isolates mesenchymal stem cells from human dental pulp. International journal of oral science 53 26674422
2004 The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E. The Journal of cell biology 53 15051733
2013 CD271 on melanoma cell is an IFN-γ-inducible immunosuppressive factor that mediates downregulation of melanoma antigens. The Journal of investigative dermatology 51 24226422
2014 CD271 is an imperfect marker for melanoma initiating cells. Oncotarget 50 25105565
2024 Exosomes derived from CD271+CD56+ bone marrow mesenchymal stem cell subpopoulation identified by single-cell RNA sequencing promote axon regeneration after spinal cord injury. Theranostics 49 38169566
1999 Differential expression of trkB.T1 and trkB.T2, truncated trkC, and p75(NGFR) in the cochlea prior to hearing function. The Journal of comparative neurology 49 10494076
1996 p75(NGFR) and TrkA receptors collaborate to rapidly activate a p75(NGFR)-associated protein kinase. The EMBO journal 49 8698038
2014 CD271+ osteosarcoma cells display stem-like properties. PloS one 47 24893164
2001 Expression and function of Xenopus laevis p75(NTR) suggest evolution of developmental regulatory mechanisms. Journal of neurobiology 41 11598917
2023 The Molecular Pathway of p75 Neurotrophin Receptor (p75NTR) in Parkinson's Disease: The Way of New Inroads. Molecular neurobiology 39 37897634
2014 Epigenetic regulation of CD271, a potential cancer stem cell marker associated with chemoresistance and metastatic capacity. Oncology reports 39 25351876
2018 The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau. Molecular psychiatry 38 29867188
2015 proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 38 26134656
2015 Update on the role of p75NTR in neurological disorders: A novel therapeutic target. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 38 26653545
2007 Roles of glial p75NTR in axonal regeneration. Journal of neuroscience research 38 17335080
2015 Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation. The Journal of neuroscience : the official journal of the Society for Neuroscience 35 26311773
2017 CD271 determines migratory properties of melanoma cells. Scientific reports 34 28852061
2016 CD271 regulates the proliferation and motility of hypopharyngeal cancer cells. Scientific reports 34 27469492
2023 The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer's Disease. International journal of molecular sciences 33 36834612
2014 CD271 mediates stem cells to early progeny transition in human epidermis. The Journal of investigative dermatology 33 25330297
2017 Multiple Autologous Bone Marrow-Derived CD271+ Mesenchymal Stem Cell Transplantation Overcomes Drug-Resistant Epilepsy in Children. Stem cells translational medicine 32 29224250
1999 Signaling of neuronal cell death by the p75NTR neurotrophin receptor. Molecular neurobiology 32 10595871
2016 CD271 Down-Regulation Promotes Melanoma Progression and Invasion in Three-Dimensional Models and in Zebrafish. The Journal of investigative dermatology 31 27328305
1999 p75(NGFR) and cholinergic neurons in the developing forebrain: a re-examination. Brain research. Developmental brain research 29 10611506
2020 p75NTR-/- mice exhibit an alveolar bone loss phenotype and inhibited PI3K/Akt/β-catenin pathway. Cell proliferation 28 32215984
2009 p75NTR as a therapeutic target for neuropsychiatric diseases. Current molecular pharmacology 28 20021447
2018 ProBDNF/p75NTR/sortilin pathway is activated in peripheral blood of patients with alcohol dependence. Translational psychiatry 27 29520063
2014 Epigenetic inactivation and tumor-suppressor behavior of NGFR in human colorectal cancer. Molecular cancer research : MCR 27 25244921
2008 Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proceedings of the National Academy of Sciences of the United States of America 27 18182498
2019 Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells. Cancer letters 26 31325530
2016 CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity. Cancer research 26 27325642
2021 CD271 antibody-functionalized microspheres capable of selective recruitment of reparative endogenous stem cells for in situ bone regeneration. Biomaterials 25 34838337
2015 Age-related decrease in CD271(+) cells in human skin. The Journal of dermatology 24 26300383
2020 Decoding the Role of CD271 in Melanoma. Cancers 23 32878000
2023 Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease. NPJ Regenerative medicine 22 37429840
2020 CD271 antibody-functionalized HGNs for targeted photothermal therapy of osteosarcoma stem cells. Nanotechnology 22 32235073
2018 Comparative characterization of CD271+ and CD271- subpopulations of CD34+ human adipose-derived stromal cells. Journal of cellular biochemistry 22 29125884
2014 Increased expression of melanoma stem cell marker CD271 in metastatic melanoma to the brain. International journal of clinical and experimental pathology 22 25674270
2011 p75(NTR) induces apoptosis in medulloblastoma cells. International journal of cancer 22 20549701
2008 Patterns of expression and function of the p75(NGFR) protein in pancreatic cancer cells and tumours. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 22 19041213
2023 Muscle denervation promotes functional interactions between glial and mesenchymal cells through NGFR and NGF. iScience 21 37416457
2017 Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells. Frontiers in immunology 21 28861085
2016 ESM1 mediates NGFR-induced invasion and metastasis in murine oral squamous cell carcinoma. Oncotarget 21 27683113
2015 NMR Dynamics of Transmembrane and Intracellular Domains of p75NTR in Lipid-Protein Nanodiscs. Biophysical journal 21 26287629
2021 The angiogenic potential of CD271+ human adipose tissue-derived mesenchymal stem cells. Stem cell research & therapy 20 33653407
2021 Enhanced pro-BDNF-p75NTR pathway activity in denervated skeletal muscle. Life sciences 20 34678261
2019 Angiogenic Potential of Bone Marrow Derived CD133+ and CD271+ Intramyocardial Stem Cell Trans- Plantation Post MI. Cells 20 31892273
2017 Cd271 mediates proliferation and differentiation of epidermal stem cells to support cutaneous burn wound healing. Cell and tissue research 20 29150821
2019 CD271 is a molecular switch with divergent roles in melanoma and melanocyte development. Scientific reports 19 31118427
2003 Osmotic swelling induces p75 neurotrophin receptor (p75NTR) expression via nitric oxide. The Journal of biological chemistry 19 12821676
2022 proBDNF/p75NTR promotes rheumatoid arthritis and inflammatory response by activating proinflammatory cytokines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18 35129860
2022 A Cd9+Cd271+ stem/progenitor population and the SHP2 pathway contribute to neonatal-to-adult switching that regulates tendon maturation. Cell reports 18 35476985
2018 Diagnostic Utility of Pax8, Pax2, and NGFR Immunohistochemical Expression in Pediatric Renal Tumors. Applied immunohistochemistry & molecular morphology : AIMM 18 28426529
2013 Adipogenic and osteogenic differentiation of Lin(-)CD271(+)Sca-1(+) adipose-derived stem cells. Molecular and cellular biochemistry 18 23430356
2012 Nerve growth factor receptor (NGFR): a potential marker for specific molecular subtypes of breast cancer. Journal of clinical pathology 18 23268325
2022 Expression of NGF/proNGF and Their Receptors TrkA, p75NTR and Sortilin in Melanoma. International journal of molecular sciences 17 35457078
2022 Neurotrophin Pathway Receptors NGFR and TrkA Control Perineural Invasion, Metastasis, and Pain in Oral Cancer. Advanced biology 17 35925599
2020 Valproic acid upregulates the expression of the p75NTR/sortilin receptor complex to induce neuronal apoptosis. Apoptosis : an international journal on programmed cell death 17 32712736
2016 Expression of SOX10, ABCB5 and CD271 in melanocytic lesions and correlation with survival data of patients with melanoma. Clinical and experimental dermatology 17 27663144
2015 Hypoxia-Inducible Factor-1α and CD271 inversely correlate with melanoma invasiveness. Experimental dermatology 17 25739328
2023 Escape from NK cell tumor surveillance by NGFR-induced lipid remodeling in melanoma. Science advances 16 36638181
2011 Biological and clinical significance of p75NTR expression in laryngeal squamous epithelia and laryngocarcinoma. Acta oto-laryngologica 16 22201277
2003 NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. International journal of oncology 16 12739005
2023 The Impact of BDNF, NTRK2, NGFR, CREB1, GSK3B, AKT, MAPK1, MTOR, PTEN, ARC, and SYN1 Genetic Polymorphisms in Antidepressant Treatment Response Phenotypes. International journal of molecular sciences 15 37047730
2016 CD271(+) stromal cells expand in arthritic synovium and exhibit a proinflammatory phenotype. Arthritis research & therapy 15 26980374
2000 Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury. Clinical and experimental pharmacology & physiology 15 10874514
2022 SorCS3 promotes the internalization of p75NTR to inhibit GBM progression. Cell death & disease 14 35393432
2018 Induction of Expression of CD271 and CD34 in Mesenchymal Stromal Cells Cultured as Spheroids. Stem cells international 14 30154865
2016 A role for NGF and its receptors TrKA and p75NTR in the progression of COPD. Biological chemistry 14 26408608
2014 Expression of p75(NGFR), a Proliferative and Basal Cell Marker, in the Buccal Mucosa Epithelium during Re-epithelialization. Acta histochemica et cytochemica 14 25392568

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