Affinage

OXTR

Oxytocin receptor · UniProt P30559

Length
389 aa
Mass
42.8 kDa
Annotated
2026-06-10
100 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

OXTR is the oxytocin receptor, a G protein-coupled receptor that couples oxytocin binding to multiple intracellular signaling cascades and governs processes ranging from uterine contractility to social and affective behavior (PMID:33707208, PMID:34489531). In myometrium, OXTR drives smooth muscle contraction through a Plcl2-Trpc3 pathway that lies downstream of progesterone receptor isoform B, which suppresses contractility by lowering Oxtr and Trpc3 while raising Plcl2 (PMID:33707208); its overexpression in myometrial cells is associated with heightened contractile amplitude (PMID:22999795). In the nervous system, distinct OXTR-expressing circuits partition behavior: septal OXTR neurons are GABAergic and project inhibitory fibers to the horizontal diagonal band to drive anxiety-like behavior (PMID:34489531), whereas OXTR neurons projecting to the nucleus accumbens from cortical, thalamic, and amygdalar sources define circuitry for social behavior (PMID:33092784). Oxytocin acting through OXTR also down-regulates mesenteric afferent sensitivity via an enteric nNOS/NO/KATP pathway (PMID:25346204) and confers hippocampal neuroprotection in sepsis-associated encephalopathy through OXTR-ERK-STAT3 signaling that limits microglial inflammation (PMID:37648002); in cancer-associated fibroblasts, OXTR activates nuclear ERK5 via Gαq and CDC37 to sustain a CCL26-dependent pro-invasive phenotype (PMID:36045118). Oxtr expression is epigenetically controlled, with TET1-mediated demethylation of Oxtr CpG islands required for normal expression, maternal care, social behavior, and oxytocin-evoked synaptic responses (PMID:30518695), and with histone modifications further tuning expression in a developmental and sex-specific manner (PMID:30650536).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2009 Medium

    Established that OTR is present in the enteric nervous system and intestinal epithelium with developmentally regulated, junction-localized expression, extending receptor function beyond classical reproductive tissue.

    Evidence RT-PCR, immunofluorescence co-localization, and immunoelectron microscopy across a developmental time course

    PMID:19003903

    Open questions at the time
    • No loss-of-function test of OTR's role in ENS development
    • Functional consequence of adherens junction localization undefined
  2. 2012 Medium

    Linked OXTR overexpression to pathological uterine contractility and showed its expression is sensitive to histone deacetylase inhibition, connecting receptor abundance to disease severity and epigenetic control.

    Evidence Western blot quantification, in vitro contractility assay, and pharmacological inhibition (TSA, andrographolide) in primary myometrial smooth muscle cells

    PMID:22999795

    Open questions at the time
    • Correlational link between OXTR level and contractility, not causal
    • TSA/andrographolide effects not OXTR-specific
  3. 2014 High

    Defined the downstream effector chain by which enteric OTR dampens visceral afferent signaling, identifying an nNOS/NO/KATP pathway.

    Evidence In vitro mesenteric afferent discharge recording with pharmacological blockade (L-NAME, NPLA, glibenclamide) and nNOS co-localization

    PMID:25346204

    Open questions at the time
    • Single lab
    • Receptor coupling step linking OTR to nNOS not resolved
  4. 2015 Medium

    Showed that uterine contractile activity itself upregulates OXTR in placental trophoblast, indicating mechanical/labor feedback onto receptor expression.

    Evidence Immunohistochemistry, Western blot, and cytotrophoblast culture comparing labor versus non-labor cesarean delivery

    PMID:26377392

    Open questions at the time
    • Mechanism by which contractility signals to trophoblast OXTR unknown
    • Functional role of trophoblast OXTR undefined
  5. 2017 Low

    Implicated OXTR sequence variation in defective uterine development, raising a candidate disease association with uterovaginal aplasia.

    Evidence Direct sequencing of OXTR coding region in 93 MRKHS patients

    PMID:28815558

    Open questions at the time
    • No functional validation that the missense variant impairs receptor function
    • No causal genetic evidence linking variant to phenotype
  6. 2018 High

    Demonstrated that TET1-mediated DNA demethylation is required to maintain Oxtr expression, tying an epigenetic enzyme to oxytocin-dependent synaptic and social behavior.

    Evidence Tet1 knockout mice with CpG methylation analysis, isoform RT-PCR, behavioral assays, and synaptic physiology

    PMID:30518695

    Open questions at the time
    • TET1 acts on many loci; behavioral phenotype not formally rescued by restoring Oxtr alone
    • Which Oxtr isoforms drive each phenotype unresolved
  7. 2018 Low

    Correlated OXTR methylation with autonomic tone via amygdala structure, beginning to connect receptor epigenetics to physiology in humans.

    Evidence Blood OXTR methylation, heart rate variability, structural MRI, and mediation analysis (N=79)

    PMID:30257007

    Open questions at the time
    • Correlational with no functional manipulation of OXTR methylation
    • Blood methylation may not reflect brain
    • Small sample
  8. 2019 Medium

    Showed sex-specific histone-mediated regulation of Oxtr by maternal diet, providing a chromatin mechanism for environmental programming of receptor expression.

    Evidence Maternal high-fat-diet mouse model with RT-qPCR and ChIP for H3K9Ac at the Oxtr TSS

    PMID:30650536

    Open questions at the time
    • Single mark, single locus; causality of H3K9Ac for expression not tested
    • Functional consequence of hippocampal Oxtr change unknown
  9. 2019 Medium

    Demonstrated that endocrine disruption (BPA) reshapes regional and sexually dimorphic brain OTR distribution, showing receptor expression is environmentally malleable.

    Evidence Rat CLARITY-BPA perinatal exposure model with receptor binding autoradiography

    PMID:31251963

    Open questions at the time
    • Mechanism linking BPA to OTR expression changes unknown
    • Behavioral consequences not established
  10. 2020 Medium

    Mapped the source neurons of OXTR-dependent NAcc-projecting circuits, providing anatomical substrate for oxytocin regulation of social behavior.

    Evidence CRISPR Oxtr-ires-Cre knock-in prairie voles with retrograde Cre-dependent AAV tracing and mRNA validation

    PMID:33092784

    Open questions at the time
    • Circuit anatomy without functional manipulation
    • Contribution of each input region to behavior unresolved
  11. 2021 High

    Placed OXTR within a defined uterine signaling module downstream of progesterone receptor isoform B, defining the Oxtr-Plcl2-Trpc3 contractility pathway.

    Evidence PGR-A/PGR-B smooth-muscle transgenic mice, uterine RNA-seq, ex vivo/in vivo contractility, and CRISPRa functional assays

    PMID:33707208

    Open questions at the time
    • Direct biochemical coupling between OXTR, PLCL2, and TRPC3 not shown
    • Human relevance not tested
  12. 2021 High

    Resolved a behaviorally distinct OXTR circuit, showing septal OXTR neurons are GABAergic and drive anxiety through inhibitory projections to the HDB.

    Evidence Chemogenetics, optogenetics, vGAT immunofluorescence, circuit tracing, and anxiety assays

    PMID:34489531

    Open questions at the time
    • Endogenous oxytocin signal driving these neurons not defined
    • Receptor-level signaling in these neurons not dissected
  13. 2022 High

    Defined a pro-tumor OXTR signaling axis in cancer-associated fibroblasts, where OXTR activates nuclear ERK5 via Gαq/CDC37 to sustain CCL26-dependent invasion.

    Evidence CAF characterization, signaling pathway dissection (Gαq/CDC37/ERK5), CCL26 functional requirement, and ERK5 ablation

    PMID:36045118

    Open questions at the time
    • Whether oxytocin ligand drives the CAF phenotype not established
    • CDC37-OXTR-ERK5 connection mechanism incompletely defined
  14. 2022 Medium

    Revealed a non-signaling pathology in which accumulated GAGs induce OXTR protein aggregation in lysosomal storage disease cells, reversible by GAG-degrading enzyme.

    Evidence MPS patient-derived cells with immunofluorescence for OXTR aggregates and enzyme replacement rescue

    PMID:35537249

    Open questions at the time
    • Functional consequence of OXTR aggregation unknown
    • Direct GAG-OXTR binding not demonstrated
  15. 2023 Medium

    Identified OXTR-ERK-STAT3 signaling as the route for oxytocin neuroprotection in sepsis-associated encephalopathy, linking the receptor to anti-inflammatory microglial modulation.

    Evidence CLP mouse SAE model with OXTR antagonist blockade (L-368,899), RNA-seq, LPS-challenged microglia assays, and behavioral/electrophysiological readouts

    PMID:37648002

    Open questions at the time
    • Cell type mediating OXTR-ERK-STAT3 effect not pinpointed
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How OXTR couples to its divergent downstream effectors (Gαq/ERK5, ERK/STAT3, nNOS/NO/KATP, Plcl2/Trpc3) in a tissue- and cell-type-specific manner, and how epigenetic state sets receptor abundance to gate these outputs, remains unresolved.
  • No unifying biochemical model linking ligand binding to pathway selection
  • Determinants of tissue-specific effector coupling unknown
  • Causal chain from methylation/histone state to phenotype not fully closed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 4
Localization
GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-112316 Neuronal System 2 R-HSA-397014 Muscle contraction 1
Partners
CDC37GNAQ

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 OTR is expressed in enteric neurons (including intrinsic primary afferent neurons identified by NeuN co-localization) and intestinal epithelium, with developmentally regulated expression peaking at postnatal day 7; OTR protein was detected at plasmalemmal enterocyte adherens junctions by immunoelectron microscopy, suggesting a role in ENS development and epithelial biology. RT-PCR, immunofluorescence co-localization, immunoelectron microscopy, developmental time-course analysis The Journal of comparative neurology Medium 19003903
2012 OXTR is overexpressed in myometrial smooth muscle cells from adenomyosis patients compared to controls; overexpression correlates with increased uterine contractile amplitude and dysmenorrhea severity; histone deacetylase inhibitor TSA and andrographolide dose-dependently inhibit OTR expression in these cells. Western blot quantification of OTR protein in primary MSMC cultures, in vitro contractility assay, pharmacological inhibition with TSA and andrographolide Fertility and sterility Medium 22999795
2014 Oxytocin down-regulates mesenteric afferent sensitivity through the enteric OTR/nNOS/NO/KATP pathway: OTR co-localizes with nNOS in myenteric plexus neurons; OTR-mediated attenuation of bradykinin- or distension-evoked afferent discharge is blocked by NOS inhibitors (L-NAME, NPLA), N/P-type calcium channel antagonists, and KATP blocker glibenclamide. In vitro mesenteric afferent discharge recording, immunofluorescence co-localization, pharmacological blockade with L-NAME/NPLA/glibenclamide Neurogastroenterology and motility High 25346204
2018 TET1 protein regulates Oxtr expression by preventing DNA hypermethylation of Oxtr CpG islands during early development; Tet1-deficient mice show reduced select Oxtr mRNA isoforms, hypermethylation of Oxtr CpG islands persisting into adulthood, impaired maternal care, impaired social behavior, and reduced synaptic responses to oxytocin stimulation. Tet1 knockout mice (exon 4 deletion), RT-PCR isoform analysis, CpG methylation analysis, behavioral assays (maternal care, social behavior), synaptic physiology JCI insight High 30518695
2021 Progesterone receptor isoform B (PGR-B) suppresses uterine contractility by reducing Oxtr and Trpc3 expression and increasing Plcl2 expression in myometrium; both PLCL1 and PLCL2 can attenuate uterine muscle cell contraction in a CRISPRa-based assay, defining an Oxtr-Plcl2-Trpc3 pathway downstream of PGR-B. Transgenic mouse models overexpressing PGR-A or PGR-B in smooth muscle, uterine RNA sequencing, ex vivo and in vivo contractility assays, CRISPRa functional assay Proceedings of the National Academy of Sciences of the United States of America High 33707208
2021 Chemogenetic activation of septal neurons expressing OXTr induces anxiety-like but not depressive-like behavior; septal OXTr neurons express vGAT (vesicular GABA transporter) and project inhibitory GABAergic fibers to the horizontal diagonal band of Broca (HDB); optogenetic stimulation of septal OXTr→HDB projections inactivates HDB neurons and elicits anxiety-like behavior. Chemogenetics (DREADD), optogenetics, immunofluorescence for vGAT, behavioral anxiety assays, circuit tracing Molecular psychiatry High 34489531
2022 OXTRHigh cancer-associated fibroblasts (CAFs) promote invasion of oral squamous cell carcinoma via ERK5 nuclear transcription signaling: OXTR activates nuclear ERK5 via Gαq and CDC37 to maintain high levels of OXTR and CCL26; CCL26 is required for the invasive phenotype of CCR3+ tumors; ERK5 ablation reprograms the pro-invasive phenotype of OXTRHigh CAFs. CAF characterization, gene expression analysis, signaling pathway dissection (Gαq/CDC37/ERK5), CCL26 functional requirement, ERK5 ablation experiments Nature communications High 36045118
2023 Oxytocin alleviates sepsis-associated encephalopathy cognitive/memory deficits and hippocampal synaptic dysfunction via OXTR; OXTR antagonist L-368,899 (intraperitoneal or local CA1 injection) blocks OXT-mediated neuroprotection; OXT reduces microglial phagocytosis and inflammatory cytokine release; the OXTR-ERK-STAT3 signaling pathway mediates the neuroprotective effects of OXT in SAE. CLP mouse model of SAE, intranasal OXT administration, OXTR antagonist blockade, RNA sequencing for pathway identification, in vitro LPS-challenged microglia assays, behavioral and electrophysiological readouts Brain, behavior, and immunity Medium 37648002
2019 Maternal high fat diet-induced obesity increases Oxtr mRNA expression ~2-fold in the hippocampus of male but not female offspring at GD17.5, associated with increased binding of active histone mark H3K9Ac at the Oxtr transcriptional start site specifically in male offspring. Mouse maternal HFD model, RT-qPCR, chromatin immunoprecipitation (ChIP) for H3K9Ac at Oxtr TSS International journal of molecular sciences Medium 30650536
2015 OXTR expression in placental trophoblast cells is significantly upregulated (~3–7-fold) in women who delivered vaginally (with uterine contractile activity) compared to those who delivered by cesarean section without labor, indicating that myometrial contractility upregulates trophoblast OXTR expression. Immunohistochemistry with quantitative morphometry, Western blot on placental tissue, primary cytotrophoblast cell culture, comparison of labor vs. non-labor delivery groups BMC pregnancy and childbirth Medium 26377392
2019 Perinatal BPA exposure eliminates sexually dimorphic OTR expression in three hypothalamic regions and alters OTR expression in the BNST of juvenile rats, demonstrating that endocrine disruption by BPA impacts regional brain OTR distribution in a sex-specific manner. Rat CLARITY-BPA model (perinatal gavage exposure), receptor binding autoradiography across brain regions Neurotoxicology Medium 31251963
2020 Oxtr-expressing neurons in prairie vole that project to the nucleus accumbens (NAcc) were mapped using Oxtr-ires-Cre knock-in voles; Oxtr-expressing neurons projecting to NAcc originate from anterior olfactory nucleus, PFC, ACC, insular cortex, paraventricular thalamus, basolateral amygdala, and cortical amygdaloid areas, defining OXTR-dependent circuits for social behavior. CRISPR/Cas9 Oxtr-ires-Cre knock-in prairie voles, retrograde Cre-dependent EGFP AAV tracing from NAcc, fluorescence imaging, mRNA co-localization validation Neuroscience Medium 33092784
2019 OXTR DNA methylation modulates the effect of intranasal oxytocin on brain responses to social interaction (Prisoner's Dilemma fMRI); OXTR methylation did not modulate OT effects in previously reported regions (caudate, amygdala, insula) but did modulate OT effects on precuneus, visual cortex, and lateral septum, with some effects being sex-specific in rs53576 GG individuals. Pharmacological fMRI with intranasal OT vs. placebo, OXTR methylation measurement from blood, correlation of methylation with blood-oxygen-level-dependent (BOLD) signal Genes, brain, and behavior Medium 30624029
2018 Increased OXTR DNA methylation is associated with attenuated resting parasympathetic tone (lower high-frequency heart rate variability), and this relationship is mediated by increased gray matter volume of the central amygdala. OXTR methylation from blood, high-frequency heart rate variability measurement, structural MRI amygdala morphometry, mediation analysis (N=79) Social cognitive and affective neuroscience Low 30257007
2022 OXTR protein forms aggregates in MPS I and MPS II patient-derived cells; these aggregates disappear upon treatment with the enzyme deficient in the respective MPS type (causing GAG degradation), suggesting that accumulated GAGs interact with OXTR to induce aggregate formation rather than changes in OXTR expression levels. Transcriptomic analysis of MPS patient cells, immunofluorescence for OXTR protein aggregates, enzyme replacement treatment, comparison with gene/protein expression levels European journal of cell biology Medium 35537249
2017 Sequence variants in the OXTR gene, including one missense mutation, were identified in MRKHS patients with uterovaginal aplasia, suggesting OXTR mutations may impair receptor function and contribute to defective uterine development. Direct DNA sequencing of full OXTR coding sequence in 93 MRKHS patients Acta obstetricia et gynecologica Scandinavica Low 28815558

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biological psychiatry 379 15992526
2008 Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social cognitive and affective neuroscience 339 19015103
2007 Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. Neuroscience letters 310 17383819
2012 Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes. Biological psychiatry 274 22336563
2007 Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. Molecular psychiatry 265 17893705
2014 The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis. Molecular psychiatry 257 25092245
2010 Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proceedings of the National Academy of Sciences of the United States of America 197 20724662
2011 Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proceedings of the National Academy of Sciences of the United States of America 194 22123970
2009 Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Progress in neuro-psychopharmacology & biological psychiatry 187 19376182
2011 Oxytocin receptor gene (OXTR) is related to psychological resources. Proceedings of the National Academy of Sciences of the United States of America 183 21896752
2014 Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder. Proceedings of the National Academy of Sciences of the United States of America 180 25092315
2009 The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. PloS one 164 19461999
2010 Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population. Journal of human genetics 147 20094064
2014 Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study. Molecular psychiatry 146 25199917
2013 Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills. Proceedings of the National Academy of Sciences of the United States of America 144 24367110
2012 The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. Journal of affective disorders 142 22357335
2015 Childhood maternal care is associated with DNA methylation of the genes for brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) in peripheral blood cells in adult men and women. Stress (Amsterdam, Netherlands) 135 26061800
2011 Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder. Journal of neurodevelopmental disorders 124 21484202
2009 Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium. The Journal of comparative neurology 110 19003903
2018 The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review. BMC psychiatry 104 29843655
2015 Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis. PloS one 104 26121678
2012 Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis. Fertility and sterility 92 22999795
2012 Does the oxytocin receptor (OXTR) polymorphism (rs2254298) confer 'vulnerability' for psychopathology or 'differential susceptibility'? Insights from evolution. BMC medicine 90 22510359
2011 Oxytocin Receptor (OXTR) Polymorphisms and Attachment in Human Infants. Frontiers in psychology 75 21904531
2017 Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness. Scientific reports 74 28785027
2016 Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype. Autism research : official journal of the International Society for Autism Research 73 27520745
2015 DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women. Frontiers in genetics 71 26175754
2008 Molecular genetic studies of the arginine vasopressin 1a receptor (AVPR1a) and the oxytocin receptor (OXTR) in human behaviour: from autism to altruism with some notes in between. Progress in brain research 71 18655900
2017 Revisiting the impact of OXTR rs53576 on empathy: A population-based study and a meta-analysis. Psychoneuroendocrinology 68 28343138
2015 Methylation of the oxytocin receptor gene in clinically depressed patients compared to controls: The role of OXTR rs53576 genotype. Journal of psychiatric research 67 25890851
2010 No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences. PloS one 64 20585395
2013 Cumulative risk on the oxytocin receptor gene (OXTR) underpins empathic communication difficulties at the first stages of romantic love. Social cognitive and affective neuroscience 61 23974948
2010 Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD. Progress in neuro-psychopharmacology & biological psychiatry 60 20347913
2018 Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood. International journal of psychophysiology : official journal of the International Organization of Psychophysiology 59 29410310
2017 Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders. Research in developmental disabilities 54 29033100
2016 Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation. Social cognitive and affective neuroscience 53 27107296
2010 The association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments, as measured by TEMPS-A. Journal of affective disorders 52 20488544
2023 Oxytocin alleviates cognitive and memory impairments by decreasing hippocampal microglial activation and synaptic defects via OXTR/ERK/STAT3 pathway in a mouse model of sepsis-associated encephalopathy. Brain, behavior, and immunity 50 37648002
2015 Oxytocin Receptor (OXTR) Single Nucleotide Polymorphisms Indirectly Predict Prosocial Behavior Through Perspective Taking and Empathic Concern. Journal of personality 48 25403479
2014 Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome. Molecular autism 48 25264479
2018 Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies. Neuroscience and biobehavioral reviews 47 30496762
2012 Associations between the oxytocin receptor gene (OXTR) and "mind-reading" in humans--an exploratory study. Nordic journal of psychiatry 45 22809402
2019 Maternal High Fat Diet-Induced Obesity Modifies Histone Binding and Expression of Oxtr in Offspring Hippocampus in a Sex-Specific Manner. International journal of molecular sciences 44 30650536
2023 Roles of the Oxytocin Receptor (OXTR) in Human Diseases. International journal of molecular sciences 43 36835321
2016 ASD and Genetic Associations with Receptors for Oxytocin and Vasopressin-AVPR1A, AVPR1B, and OXTR. Frontiers in neuroscience 43 27920663
2014 Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards. Molecular autism 41 24485285
2018 Intranasal oxytocin and OXTR genotype effects on resting state functional connectivity: A systematic review. Neuroscience and biobehavioral reviews 38 30243577
2022 OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling. Nature communications 37 36045118
2017 A functional polymorphism of the OXTR gene is associated with autistic traits in Caucasian and Asian populations. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 36 29027364
2020 Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity. Translational psychiatry 35 32127526
2013 Environmental stress, oxytocin receptor gene (OXTR) polymorphism, and mental health following collective stress. Hormones and behavior 33 23470776
2013 Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects. NeuroImage 33 23684879
2019 Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study. Neurotoxicology 32 31251963
2014 Association between the oxytocin receptor (OXTR) gene and children's social cognition at 18 months. Genes, brain, and behavior 31 24916666
2013 The oxytocin receptor gene (OXTR) in relation to state levels of loneliness in adolescence: evidence for micro-level gene-environment interactions. PloS one 31 24223720
2021 Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility. Proceedings of the National Academy of Sciences of the United States of America 30 33707208
2020 Investigation of Oxtr-expressing Neurons Projecting to Nucleus Accumbens using Oxtr-ires-Cre Knock-in prairie Voles (Microtus ochrogaster). Neuroscience 30 33092784
2022 Oxytocin receptor gene (OXTR) polymorphisms and social, emotional and behavioral functioning in children and adolescents: A systematic narrative review. Neuroscience and biobehavioral reviews 28 35149102
2021 An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis. Comprehensive psychoneuroendocrinology 28 35757665
2014 The influence of infant-caregiver experiences on amygdala Bdnf, OXTr, and NPY expression in developing and adult male and female rats. Behavioural brain research 28 25011012
2012 Associations between oxytocin receptor gene (OXTR) polymorphisms and self-reported aggressive behavior and anger: Interactions with alcohol consumption. Psychoneuroendocrinology 28 22421562
2019 Methylation of the OXTR gene in women with anorexia nervosa: Relationship to social behavior. European eating disorders review : the journal of the Eating Disorders Association 27 31823473
2018 Genetic and epigenetic regulatory mechanisms of the oxytocin receptor gene (OXTR) and the (clinical) implications for social behavior. Hormones and behavior 27 29505762
2019 OXTR methylation modulates exogenous oxytocin effects on human brain activity during social interaction. Genes, brain, and behavior 26 30624029
2019 Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems. Scientific reports 26 31118457
2013 The association between the oxytocin receptor gene (OXTR) and hypnotizability. Psychoneuroendocrinology 26 23562248
2021 Hypermethylation of the oxytocin receptor gene (OXTR) in obsessive-compulsive disorder: further evidence for a biomarker of disease and treatment response. Epigenetics 25 34269138
2021 Activation of septal OXTr neurons induces anxiety- but not depressive-like behaviors. Molecular psychiatry 25 34489531
2018 Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders. JCI insight 25 30518695
2014 Behavioral responses to pups in males with different reproductive experiences are associated with changes in central OT, TH and OTR, D1R, D2R mRNA expression in mandarin voles. Hormones and behavior 25 25496756
2016 Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment. Social cognitive and affective neuroscience 24 27497314
2014 Personality, behavior and environmental features associated with OXTR genetic variants in British mothers. PloS one 24 24621820
2010 Dermatologic management, sun avoidance and vitamin D status in organ transplant recipients (OTR). Journal of photochemistry and photobiology. B, Biology 24 20434355
2016 Relationship of a common OXTR gene variant to brain structure and default mode network function in healthy humans. NeuroImage 23 28017919
2021 Oxtr/TRPV1 expression and acclimation of skeletal muscle to cold-stress in male mice. The Journal of endocrinology 22 33705350
2021 The influence of rs53576 polymorphism in the oxytocin receptor (OXTR) gene on empathy in healthy adults by subtype and ethnicity: a systematic review and meta-analysis. Reviews in the neurosciences 21 33892530
2015 Gene-environment interaction between the oxytocin receptor (OXTR) gene and parenting behaviour on children's theory of mind. Social cognitive and affective neuroscience 20 25977357
2015 Myometrial contractility influences oxytocin receptor (OXTR) expression in term trophoblast cells obtained from the maternal surface of the human placenta. BMC pregnancy and childbirth 20 26377392
2012 Sexually dimorphic effects of oxytocin receptor gene (OXTR ) variants on Harm Avoidance. Biology of sex differences 20 22846218
2012 Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression. Neuroscience letters 19 22487732
2018 DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology. Social cognitive and affective neuroscience 18 30257007
2016 Lessons from the canine Oxtr gene: populations, variants and functional aspects. Genes, brain, and behavior 18 27860243
2014 Oxytocin down-regulates mesenteric afferent sensitivity via the enteric OTR/nNOS/NO/KATP pathway in rat. Neurogastroenterology and motility 18 25346204
2013 Oxytocin receptor gene (OXTR) in relation to loneliness in adolescence: interactions with sex, parental support, and DRD2 and 5-HTTLPR genotypes. Psychiatric genetics 18 23838880
2020 Interactions of OXTR rs53576 and emotional trauma on hippocampal volumes and perceived social support in adolescent girls. Psychoneuroendocrinology 17 32199286
2017 Genetic variants in oxytocin receptor gene (OXTR) and childhood physical abuse collaborate to modify the risk of aggression in chinese adolescents. Journal of affective disorders 17 29306689
2012 The expression of ERα, OTR, cPLA(2), COX-2, and PPARγ in the cervix of the ewe during the estrous cycle. Theriogenology 17 23117133
2018 Evidence for Association Between OXTR Gene and ASD Clinical Phenotypes. Journal of molecular neuroscience : MN 15 29858823
2017 Sequence variants in ESR1 and OXTR are associated with Mayer-Rokitansky-Küster-Hauser syndrome. Acta obstetricia et gynecologica Scandinavica 15 28815558
2013 Navigating the complex path between the oxytocin receptor gene (OXTR) and cooperation: an endophenotype approach. Frontiers in human neuroscience 15 24348360
2020 Oxytocin Receptor Gene (OXTR) and Childhood Adversity Influence Trust. Psychoneuroendocrinology 14 32866773
2020 Oxytocin Prevents the Development of 3-NP-Induced Anxiety and Depression in Male and Female Rats: Possible Interaction of OXTR and mGluR2. Cellular and molecular neurobiology 14 33201416
2016 The Oxytocin Receptor Gene ( OXTR) and Face Recognition. Psychological science 14 27837182
2005 PCR detection of oxytetracycline resistance genes otr(A) and otr(B) in tetracycline-resistant streptomycete isolates from diverse habitats. Current microbiology 14 16132462
2020 The Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Antisocial Behavior: A Meta-analysis. Behavior genetics 13 32060678
2020 Burnout in university faculty: An interaction between subjective sleep quality and the OXTR rs2268498 polymorphism. Journal of affective disorders 13 32739712
2019 Associations between oxytocin receptor gene (OXTR) polymorphisms, childhood trauma, and parenting behavior. Developmental psychology 13 31282733
2015 Novel rare variations of the oxytocin receptor (OXTR) gene in autism spectrum disorder individuals. Human genome variation 13 27081536
2022 Changes in expression of signal transduction-related genes, and formation of aggregates of GPER1 and OXTR receptors in mucopolysaccharidosis cells. European journal of cell biology 12 35537249
2016 Oxytocin Receptor (OXTR) Methylation and Cognition in Psychotic Disorders. Molecular neuropsychiatry 12 27867940

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