Affinage

OMP

Olfactory marker protein · UniProt P47874

Length
163 aa
Mass
18.9 kDa
Annotated
2026-06-10
100 papers in source corpus 12 papers cited in narrative 12 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

OMP (Olfactory Marker Protein) is a cytoplasmic protein of mature olfactory sensory neurons that functions as a modulator of the odor signal transduction cascade (PMID:8790421). Genetic deletion in mice reduces electroolfactogram amplitudes, prolongs onset and recovery kinetics, and impairs responses to successive odor pulses (PMID:8790421), with parallel behavioral deficits including a ~300-fold elevation in detection threshold (PMID:10094125) and degraded odor quality discrimination (PMID:11439451); adenoviral reintroduction of OMP into adult OMP-null olfactory epithelium restores both response kinetics (PMID:11036268) and threshold sensitivity (PMID:15174942), establishing a direct, non-developmental role in transduction. Structurally, OMP adopts a single globular beta-clam (beta-sandwich) fold whose inter-sheet cleft serves as a protein interaction surface that binds a Bex1-derived peptide (PMID:12054873), and Bex family members (Bex1/2/3) are physical partners of OMP in olfactory neurons (PMID:12911636). Mechanistically, OMP facilitates Na+/Ca2+-exchanger (NCX) activity to enable rapid Ca2+ extrusion from sensory neuron dendritic knobs, with OMP-null neurons showing impaired NCX-mediated Ca2+ homeostasis; this is proposed to occur through a Bex–calmodulin intermediary, as the NCX XIP regulatory peptide binds calmodulin and calmodulin binds Bex, and NCX1 co-localizes with OMP in cilia and knobs (PMID:19165324). Beyond signal transduction, OMP is required dose-dependently for formation and refinement of the olfactory glomerular map, with its loss producing glomeruli aberrantly co-innervated by neurons expressing different odorant receptors (PMID:30498219). Neuron-specific expression is governed by an intronless, TATA/CAAT-less promoter containing Olf-1 sites and an NF-1-family binding element (PMID:8034318).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1996 High

    Whether OMP played any functional role in olfaction was unknown; deleting it established OMP as a modulatory component of the odor detection/transduction cascade.

    Evidence Gene-targeted OMP-null mice assayed by electroolfactogram and behavioral odorant stimulation

    PMID:8790421

    Open questions at the time
    • Does not identify the molecular target through which OMP shapes response kinetics
    • Cannot distinguish a transduction role from a developmental consequence of deletion
  2. 1999 Medium

    It was unclear whether the electrophysiological deficit translated to perceptual sensitivity; threshold testing showed OMP-null mice are ~300-fold less sensitive, confirming an in vivo role in odor detection.

    Evidence Behavioral psychophysical threshold testing in OMP-null vs. wild-type mice

    PMID:10094125

    Open questions at the time
    • Single lab, single behavioral method
    • Does not connect the threshold shift to a defined molecular mechanism
  3. 2000 High

    It was uncertain whether the KO phenotype reflected a direct OMP function or a developmental artifact; adenoviral re-expression in adult null mice rescued response kinetics, proving a direct transduction role.

    Evidence Adenoviral OMP delivery to adult olfactory epithelium with before/after electroolfactogram recording

    PMID:11036268

    Open questions at the time
    • Does not reveal the molecular partner or biochemical activity restored
    • Limited to kinetic readouts of the EOG
  4. 2001 Medium

    Beyond sensitivity, whether OMP affected odor identity was unknown; OMP-null mice showed altered multidimensional odor identification, implicating OMP in odor quality processing.

    Evidence 5-odorant confusion-matrix identification task with multidimensional scaling in OMP-null mice

    PMID:11439451

    Open questions at the time
    • Single behavioral assay, single lab
    • Does not localize the deficit to epithelium vs. central processing
  5. 2002 High

    The structural basis of OMP function was unknown; NMR revealed a beta-clam fold with an inter-sheet cleft that binds a Bex1-derived peptide, defining a protein-interaction surface.

    Evidence NMR solution structure determination with peptide-titration binding mapping

    PMID:12054873

    Open questions at the time
    • Peptide titration does not establish full-length Bex binding affinity in vivo
    • No structure of an OMP-partner complex
  6. 2003 Medium

    The identity of OMP partners was open; phage display and cross-linking identified the Bex family (Bex1/2/3) as binding partners that co-localize with OMP in cytoplasm and nucleus.

    Evidence Phage-display cDNA screening, chemical cross-linking, in situ hybridization, and HEK293 co-transfection

    PMID:12911636

    Open questions at the time
    • Co-localization in HEK293 may not reflect olfactory neuron compartmentalization
    • Functional consequence of the OMP-Bex interaction not yet defined
  7. 2003 Medium

    A neurophysiological substrate for altered odor quality perception was lacking; voltage-sensitive dye imaging showed degraded spatiotemporal mucosal activity patterns in OMP-null mice.

    Evidence Voltage-sensitive dye optical imaging of olfactory epithelium in OMP-null vs. wild-type mice

    PMID:12917392

    Open questions at the time
    • Imaging does not pinpoint the molecular defect causing pattern degradation
    • Single method, single lab
  8. 2004 Medium

    The oligomeric and subcellular state of OMP was unknown; OMP was found to form a covalent homodimer that preferentially associates with Bex and partitions to a cytoskeletal fraction, distinct from the monomer in nucleus and cytosol.

    Evidence Immunoprecipitation, mass spectrometry, 2D gels, subcellular fractionation, and stability assays

    PMID:15198671

    Open questions at the time
    • Functional role of the dimer vs. monomer not established
    • Single lab, no in vivo manipulation of dimerization
  9. 2004 High

    Whether OMP re-expression could restore the perceptual deficit was untested; adenoviral rescue restored behavioral threshold sensitivity to control levels, confirming a role in olfactory amplification/transduction.

    Evidence Adenoviral OMP delivery to olfactory epithelium with psychophysical threshold testing in OMP-null mice

    PMID:15174942

    Open questions at the time
    • Does not define the biochemical step amplified
    • Behavioral rescue does not resolve the molecular mechanism
  10. 2009 Medium

    The biochemical mechanism linking OMP to transduction was unresolved; OMP was shown to facilitate NCX-mediated Ca2+ extrusion, proposed to act via a Bex-calmodulin intermediary, providing a molecular model for its modulatory effect.

    Evidence Single-cell Ca2+ imaging in WT vs. OMP-/- epithelium, surface plasmon resonance peptide-binding assays, and immunohistochemistry co-localization

    PMID:19165324

    Open questions at the time
    • The Bex-CaM-NCX linkage is inferred from separate binding pairs, not a reconstituted complex
    • Direct OMP-NCX or OMP-CaM interaction not demonstrated
  11. 2018 High

    Whether OMP shaped circuit wiring as well as transduction was unknown; functional and genetic imaging showed OMP is required dose-dependently for glomerular map refinement, preventing co-innervation by neurons of different odorant receptors.

    Evidence synaptopHluorin knock-in mice, two-photon glomerular imaging, and single-odorant-receptor genetic targeting in OMP-/- and OMP+/- mice

    PMID:30498219

    Open questions at the time
    • Molecular mechanism by which OMP guides axon targeting is undefined
    • Does not connect the wiring role to the NCX/Ca2+ transduction function

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown how OMP's biochemical activity (NCX facilitation, Bex/calmodulin binding, dimerization) mechanistically connects to its role in glomerular axon targeting, and whether a direct OMP-NCX-CaM complex exists.
  • No reconstituted OMP-Bex-CaM-NCX complex
  • No structure of OMP bound to a full-length partner
  • Mechanism coupling Ca2+ handling to axon guidance unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 2 GO:0098772 molecular function regulator activity 1
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 2 GO:0005856 cytoskeleton 1 GO:0005929 cilium 1
Pathway
R-HSA-9709957 Sensory Perception 3 R-HSA-112316 Neuronal System 2
Partners
BEX1BEX2BEX3CALM1NCX1

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 Deletion of the OMP gene in mice (OMP-null) causes a 20-40% reduction in maximal electroolfactogram (EOG) amplitude to multiple odorants, prolonged onset and recovery kinetics following isoamyl acetate stimulation, and impaired ability to respond to a second odor pulse, establishing OMP as a modulatory component of the odor detection/signal transduction cascade in olfactory sensory neurons. Gene targeting in embryonic stem cells; electroolfactogram recording; behavioral odorant stimulation paradigms Proceedings of the National Academy of Sciences of the United States of America High 8790421
1999 OMP gene deletion results in a significant elevation in behavioral olfactory threshold sensitivity (OMP-null mice were ~300-fold less sensitive to propanol than controls), confirming OMP's role in modulating the odor detection/signal transduction process in vivo. Behavioral psychophysical threshold testing (air vs. odor discrimination) in OMP-null vs. wild-type mice Neuroreport Medium 10094125
2000 Adenoviral vector-mediated reintroduction of OMP into olfactory receptor neurons of adult OMP-null mice rescues the kinetics of electrophysiological responses, restoring them to control phenotype; this demonstrates that OMP's role in olfactory transduction is direct and not a developmental artifact of gene deletion. Adenoviral gene delivery to olfactory epithelium; electroolfactogram recording before and after rescue Nature neuroscience High 11036268
2001 OMP gene deletion alters odorant quality perception; OMP-null mice show a significantly different multidimensional odorant identification profile compared to controls in a 5-odorant confusion matrix task, indicating OMP is critically involved in odor quality processing. 5-odorant identification confusion matrix behavioral task with multidimensional scaling analysis in OMP-null vs. wild-type mice Behavioral neuroscience Medium 11439451
2002 NMR solution structure of OMP reveals a single globular domain with a beta-clam (beta-sandwich) fold comprising eight beta-strands forming two orthogonally oriented beta-sheets, with two long alpha-helices and three flexible loops. Peptide titration experiments identified the cleft between the two beta-sheets as the binding surface for a peptide derived from the Bex1 protein, implicating this surface in protein-protein interactions relevant to olfactory signal transduction. NMR structure determination; peptide titration NMR experiments mapping binding surface Journal of molecular biology High 12054873
2003 Members of the Bex gene family (Bex1, Bex2, Bex3) are binding partners of OMP in olfactory receptor neurons. Bex2 was identified by phage-display screening of an olfactory mucosal cDNA library, the OMP/Bex interaction was confirmed by chemical cross-linking of recombinant OMP with a Bex-derived peptide, and co-transfection in HEK293 cells revealed that OMP co-localizes with Bex in both cytoplasm and nucleus. Phage-display cDNA library screening; chemical cross-linking; in situ hybridization; co-transfection in HEK293 cells Journal of neurochemistry Medium 12911636
2003 OMP gene deletion results in degraded and altered odorant-induced spatiotemporal mucosal activity patterns (recorded by voltage-sensitive dye optical imaging), providing a neurophysiological substrate for the previously observed changes in odorant quality perception in OMP-null mice. Voltage-sensitive dye optical imaging of olfactory epithelium in OMP-null vs. wild-type mice Journal of neurophysiology Medium 12917392
2004 OMP forms a covalently cross-linked homodimer (38 kDa) in addition to the monomer (19 kDa) in vivo. The dimer is preferentially co-immunoprecipitated with Bex, has a much shorter half-life than the monomer, and is preferentially localized in a Triton X-100-insoluble cytoskeletal fraction, while the monomer is present in both nuclear and cytosolic compartments. Immunoprecipitation; in-gel tryptic digestion and mass spectrometry; 2D gel electrophoresis; subcellular fractionation; transfected cell stability assays Journal of neurochemistry Medium 15198671
2004 Adenoviral vector-mediated rescue of OMP expression in OMP-null mice restores behavioral olfactory threshold sensitivity to control levels, confirming that OMP functions as an important component in olfactory signal amplification and/or transduction. Adenoviral gene delivery to olfactory epithelium; psychophysical behavioral threshold testing in OMP-null mice Behavioral neuroscience High 15174942
2009 OMP facilitates Na+/Ca2+-exchanger (NCX) activity in olfactory sensory neurons, enabling rapid Ca2+ extrusion from OSN dendritic knobs. OMP-null mice show impaired Ca2+ homeostasis with reduced NCX-mediated Ca2+ extrusion. Mechanistically, surface plasmon resonance demonstrated a direct interaction between the XIP regulatory peptide of NCX and calmodulin (CaM); since CaM also binds to Bex (an OMP interacting partner), OMP is proposed to influence NCX activity through a Bex-CaM intermediary. NCX1 and OMP co-localize in cilia and knobs of OSNs by immunohistochemistry. Single-cell Ca2+ imaging in intact olfactory epithelium (WT vs. OMP-/- mice); surface plasmon resonance protein-peptide binding assays; immunohistochemistry co-localization PloS one Medium 19165324
2018 OMP is required for proper formation and refinement of the olfactory glomerular map. In OMP-/- mice, individual glomeruli are frequently co-innervated by olfactory sensory neurons expressing different odorant receptors, causing functionally heterogeneous glomeruli with distinct odor-response microdomains. OMP+/- mice show rare glomerular heterogeneity, indicating a dose-dependent role for OMP in axon targeting. Knock-in mice expressing synaptopHluorin in place of one or both OMP alleles; two-photon imaging of glomerular odor responses; genetic targeting of single odorant receptors to visualize innervation patterns Nature communications High 30498219
1994 The human OMP gene is intronless, lacks canonical TATA and CAAT motifs, and contains conserved Olf-1 binding sites and an upstream binding region (UBE) with similarity to NF-1 family transcription factor binding motifs; gel mobility shift assays confirm NF-1 family binding to the UBE site, providing insight into mechanisms of neuron-specific OMP transcriptional regulation. Gene cloning and sequencing; gel mobility shift assays (EMSA) for transcription factor binding Genomics Medium 8034318

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain. Cell 413 12679035
2006 SigmaE-dependent small RNAs of Salmonella respond to membrane stress by accelerating global omp mRNA decay. Molecular microbiology 302 17427289
2014 Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28. Pharmacology & therapeutics 210 25172549
2001 Catalytic proficiency: the unusual case of OMP decarboxylase. Annual review of biochemistry 201 12045113
2017 A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 178 28954784
1996 Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons. Proceedings of the National Academy of Sciences of the United States of America 153 8790421
2020 Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer. Breast cancer research and treatment 119 32803633
1991 Attacin, an antibacterial protein from Hyalophora cecropia, inhibits synthesis of outer membrane proteins in Escherichia coli by interfering with omp gene transcription. Infection and immunity 108 1715318
1994 Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. Genomics 91 8034318
1997 DNA polymorphism at the omp-31 locus of Brucella spp.: evidence for a large deletion in Brucella abortus, and other species-specific markers. Microbiology (Reading, England) 86 9308175
2005 Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae. Mechanisms of development 79 15905077
2007 Physical principles and visual-OMP software for optimal PCR design. Methods in molecular biology (Clifton, N.J.) 74 17951788
2007 Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress. Genes & development 73 17938245
1999 OMP gene deletion causes an elevation in behavioral threshold sensitivity. Neuroreport 72 10094125
1993 Characterization of neuronal cell varieties migrating from the olfactory epithelium during prenatal development in the rat. Immunocytochemical study using antibodies against olfactory marker protein (OMP) and luteinizing hormone-releasing hormone (LH-RH). Brain research. Developmental brain research 72 8491043
2018 A first-in-human phase 1a study of the bispecific anti-DLL4/anti-VEGF antibody navicixizumab (OMP-305B83) in patients with previously treated solid tumors. Investigational new drugs 67 30229512
2018 A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors. Investigational new drugs 63 30591982
2000 Adenoviral vector-mediated rescue of the OMP-null phenotype in vivo. Nature neuroscience 62 11036268
1987 Cloning and expression of the OMP decarboxylase gene URA4 from Schizosaccharomyces pombe. Current genetics 61 2834100
2001 Construction and characterization of genetically defined aro omp mutants of enterotoxigenic Escherichia coli and preliminary studies of safety and immunogenicity in humans. Infection and immunity 56 11447175
1983 Structural gene coding for multifunctional protein carrying orotate phosphoribosyltransferase and OMP decarboxylase activity is located on long arm of human chromosome 3. Somatic cell genetics 56 6574608
2009 Induction of immune response to the 17 kDa OMPA Burkholderia cenocepacia polypeptide and protection against pulmonary infection in mice after nasal vaccination with an OMP nanoemulsion-based vaccine. Medical microbiology and immunology 55 19967396
2018 Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map. Nature communications 51 30498219
1992 Isolation and cloning of Omp alpha, a coiled-coil protein spanning the periplasmic space of the ancestral eubacterium Thermotoga maritima. The EMBO journal 51 1330536
2001 OMP gene deletion results in an alteration in odorant quality perception. Behavioral neuroscience 50 11439451
2005 Diversity of "Candidatus Liberibacter asiaticus," based on the omp gene sequence. Applied and environmental microbiology 49 16269671
1995 Model structure of the Omp alpha rod, a parallel four-stranded coiled coil from the hyperthermophilic eubacterium Thermotoga maritima. Journal of molecular biology 48 7731042
1988 Sequence analysis of the DdPYR5-6 gene coding for UMP synthase in Dictyostelium discoideum and comparison with orotate phosphoribosyl transferases and OMP decarboxylases. Molecular & general genetics : MGG 48 2835631
2005 Outer membrane protein (OMP) based vaccine for Neisseria meningitidis serogroup B. Vaccine 45 15755596
2008 Expression and porin activity of P28 and OMP-1F during intracellular Ehrlichia chaffeensis development. Journal of bacteriology 44 18359808
2005 A novel population of neuronal cells expressing the olfactory marker protein (OMP) in the anterior/dorsal region of the nasal cavity. Histochemistry and cell biology 43 16273384
1999 Motional dynamics of the catalytic loop in OMP synthase. Biochemistry 43 9890909
2009 Ca extrusion by NCX is compromised in olfactory sensory neurons of OMP mice. PloS one 42 19165324
2000 Molecular cloning, sequencing, and expression of omp-40, the gene coding for the major outer membrane protein from the acidophilic bacterium Thiobacillus ferrooxidans. Applied and environmental microbiology 41 10831405
2009 OMP peptides modulate the activity of DegS protease by differential binding to active and inactive conformations. Molecular cell 40 19150428
1988 Definition of meningococcal class 1 OMP subtyping antigens by monoclonal antibodies. FEMS microbiology immunology 40 3152545
2009 OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism. Structure (London, England : 1993) 39 19836340
2002 Selective ablation of olfactory receptor neurons without functional impairment of vomeronasal receptor neurons in OMP-ntr transgenic mice. The European journal of neuroscience 39 12492426
1992 Efficient transformation of Claviceps purpurea using pyrimidine auxotrophic mutants: cloning of the OMP decarboxylase gene. Molecular & general genetics : MGG 39 1508154
2021 The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding. Nature communications 38 34234105
2010 Accelerated microevolution in an outer membrane protein (OMP) of the intracellular bacteria Wolbachia. BMC evolutionary biology 38 20163713
2004 The interaction of Bex and OMP reveals a dimer of OMP with a short half-life. Journal of neurochemistry 37 15198671
1983 omp T: Escherichia coli K-12 structural gene for protein a (3b). Journal of bacteriology 35 6337119
2002 Selective targeting of zebrafish olfactory receptor neurons by the endogenous OMP promoter. The European journal of neuroscience 33 11906521
2015 Parenteral immunization of PLA/PLGA nanoparticle encapsulating outer membrane protein (Omp) from Aeromonas hydrophila: Evaluation of immunostimulatory action in Labeo rohita (rohu). Fish & shellfish immunology 32 25689492
2003 Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners. Journal of neurochemistry 31 12911636
2011 OMP-ZsGreen fluorescent protein transgenic mice for visualisation of olfactory sensory neurons in vivo and in vitro. Journal of neuroscience methods 30 21236301
2005 The effective molarity of the substrate phosphoryl group in the transition state for yeast OMP decarboxylase. Bioorganic chemistry 30 15668182
2003 OMP gene deletion results in an alteration in odorant-induced mucosal activity patterns. Journal of neurophysiology 30 12917392
2008 Mechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase. Journal of the American Chemical Society 29 18839943
1995 Serum antibodies to outer membrane proteins (OMPs) of Moraxella (Branhamella) catarrhalis in patients with bronchiectasis: identification of OMP B1 as an important antigen. Infection and immunity 29 7890418
1994 Comparison of Chlamydia pneumoniae isolates by western blot (immunoblot) analysis and DNA sequencing of the omp 2 gene. Journal of clinical microbiology 29 7852577
2002 Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction. Journal of molecular biology 28 12054873
1993 Differential OMP expression in opossum accessory olfactory bulb. Neuroreport 27 8298073
2003 Phase I study of detoxified Escherichia coli J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) complex vaccine in human subjects. Vaccine 26 14575770
2017 Identifying components required for OMP biogenesis as novel targets for antiinfective drugs. Virulence 25 28118090
1989 Effects of beta-lactamases and omp mutation on susceptibility to beta-lactam antibiotics in Escherichia coli. Antimicrobial agents and chemotherapy 25 2658786
2004 Adenoviral vector-mediated rescue of the OMP-null behavioral phenotype: enhancement of odorant threshold sensitivity. Behavioral neuroscience 24 15174942
1992 The orotidine-5'-monophosphate decarboxylase gene of Myxococcus xanthus. Comparison to the OMP decarboxylase gene family. The Journal of biological chemistry 24 1730672
2006 First detection of olfactory marker protein (OMP) immunoreactivity in the olfactory epithelium of a cartilaginous fish. Neuroscience letters 23 17174032
2000 Comparison of outer membrane protein genes omp and pmp in the whole genome sequences of Chlamydia pneumoniae isolates from Japan and the United States. The Journal of infectious diseases 21 10839753
1996 Essential role of thyroid hormones in maturation of olfactory receptor neurons: an immunocytochemical study of number and cytoarchitecture of OMP-positive cells in developing rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 21 9010731
2017 Inactivation of the olfactory marker protein (OMP) gene in river dolphins and other odontocete cetaceans. Molecular phylogenetics and evolution 20 28193458
2009 Orotic acid decarboxylation in water and nonpolar solvents: a potential role for desolvation in the action of OMP decarboxylase. Biochemistry 20 19678695
2002 Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media. Vaccine 20 12297406
2008 Mucosal immunization of mice with recombinant OMP P2 induces antibodies that bind to surface epitopes of multiple strains of nontypeable Haemophilus influenzae. Mucosal immunology 19 19079335
2007 OMP decarboxylase--An enigma persists. Bioorganic chemistry 19 17889251
1995 Distribution of OMP-, PGP 9.5- and CaBP-like immunoreactive chemoreceptor neurons in the developing human olfactory epithelium. Anatomy and embryology 19 7645757
2015 Serum antibody response to Moraxella catarrhalis proteins OMP CD, OppA, Msp22, Hag, and PilA2 after nasopharyngeal colonization and acute otitis media in children. Vaccine 18 26392013
2014 Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution. Proceedings of the National Academy of Sciences of the United States of America 17 25275007
1980 Measure of asymmetrical transcription of the yeast OMP decarboxylase gene expressed in yeast or in E. coli. Current genetics 17 24189800
1996 LacZ and OMP are co-expressed during ontogeny and regeneration in olfactory receptor neurons of OMP promoter-lacZ transgenic mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 16 9010727
2012 Structure of Salmonella typhimurium OMP synthase in a complete substrate complex. Biochemistry 15 22531064
2023 Conformational rearrangements in the sensory RcsF/OMP complex mediate signal transduction across the bacterial cell envelope. PLoS genetics 14 36706155
1995 Human olfactory receptor neurons contain OMP mRNA in their dendritic and axonal processes. Neuroreport 14 7605954
1984 Sequence of the regulatory region of omp T, the gene specifying major outer membrane protein a (3b) of Escherichia coli K-12: implications for regulation and processing. Molecular & general genetics : MGG 14 6323918
2020 Reversal of Olfactory Disturbance in Allergic Rhinitis Related to OMP Suppression by Intranasal Budesonide Treatment. Allergy, asthma & immunology research 13 31743968
2015 Development of OMP based indirect ELISA to gauge the antibody titers in bovines against Pasteurella multocida. Iranian journal of veterinary research 13 27175202
2004 OMP decarboxylase: an experimental test of electrostatic destabilization of the enzyme-substrate complex. Journal of the American Chemical Society 13 15535676
2022 Efficacy and Immune Correlates of OMP-1B and VirB2-4 Vaccines for Protection of Dogs from Tick Transmission of Ehrlichia chaffeensis. mBio 12 36342170
2021 Oral delivery of pVAX-OMP and pVAX-hly DNA vaccine using chitosan-tripolyphosphate (Cs-TPP) nanoparticles in Rohu, (Labeo rohita) for protection against Aeromonas hydrophila infection. Fish & shellfish immunology 12 34147613
2021 Hybrid recombinant Omp 22, 25, and 31 immunodominant epitopes can be used for serodiagnosis of brucellosis. Journal of immunological methods 12 34428402
2007 Positively selected codons in immune-exposed loops of the vaccine candidate OMP-P1 of Haemophilus influenzae. Journal of molecular evolution 12 17479342
2019 Distribution of Chlamydia trachomatis omp A genotypes in patients attending a sexually transmitted disease outpatient clinic in New Delhi, India. The Indian journal of medical research 11 31417035
2016 Proteomic characterization of oyster shell organic matrix proteins (OMP). Bioinformation 11 28246460
2009 Promoter analysis of macrophage- and tick cell-specific differentially expressed Ehrlichia chaffeensis p28-Omp genes. BMC microbiology 11 19454021
2005 Identification and characterization of a novel outer membrane protein (OMP J) of Moraxella catarrhalis that exists in two major forms. Journal of bacteriology 11 16291671
2024 Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing ferroptosis. Toxicology and applied pharmacology 10 38253083
2020 Designing an Outer Membrane Protein (Omp-W) Based Vaccine for Immunization against Vibrio and Salmonella: An in silico Approach. Recent patents on biotechnology 10 32990553
2016 In silico identification of outer membrane protein (Omp) and subunit vaccine design against pathogenic Vibrio cholerae. Computational biology and chemistry 10 27769003
2010 Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4. Vaccine 10 20170768
2002 Antimicrobial susceptibility changes and T-OMP shifts in pyrithione-passaged planktonic cultures of Pseudomonas aeruginosa PAO1. Journal of applied microbiology 10 11966914
2021 Evaluation of the diagnostic potential of recombinant leptospiral OMP A-like protein (Loa22) and transmembrane (OmpL37) protein in latex agglutination test for serodiagnosis of leptospirosis in animals. Letters in applied microbiology 9 33590504
2008 Induction of a protective immune response against swine Chlamydophila abortus infection in mice following co-vaccination of omp-1 DNA with recombinant MOMP. Zoonoses and public health 9 18721226
1993 Detection of antibodies against Salmonella typhi outer membrane protein (OMP) preparation in typhoid fever patients. Asian Pacific journal of allergy and immunology 9 8216558
2024 Development of label-free electrochemical OMP-DNA probe biosensor as a highly sensitive system to detect of citrus huanglongbing. Scientific reports 8 38806617
2022 Interaction of 43K OMP of Fusobacterium necrophorum with fibronectin mediates adhesion to bovine epithelial cells. Veterinary microbiology 8 35121302
2022 Efficacy of recombinant subunit OMP and hly vaccines against Aeromonas hydrophila in Rohu (Labeo rohita). Journal of fish diseases 8 35810483
2013 Catalytic site interactions in yeast OMP synthase. Archives of biochemistry and biophysics 8 24262852
2003 Construction and characterization of bivalent vaccine candidate expressing HspA and M(r)18,000 OMP from Helicobacter pylori. World journal of gastroenterology 8 12918115

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