Affinage

NPY5R

Neuropeptide Y receptor type 5 · UniProt Q15761

Length
445 aa
Mass
50.7 kDa
Annotated
2026-04-29
88 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NPY5R is a Gi/o-coupled receptor for neuropeptide Y (NPY) and peptide YY (PYY) that functions as a central regulator of energy homeostasis, feeding behavior, and emotional state, while also mediating peripheral proliferative and metabolic signaling. In the hypothalamus, NPY5R localizes to neuronal primary cilia via the Bardet-Biedl syndrome (BBS) trafficking pathway, and this ciliary targeting is required for normal anorexigenic responses to PYY3-36; NPY5R exhibits functional redundancy with NPY1R in central orexigenic signaling, though in the lateral hypothalamic area it becomes the dominant orexigenic receptor subtype under high-fat diet conditions (PMID:24316073, PMID:14525913, PMID:31887359). Beyond feeding, NPY5R in the paraventricular thalamus mediates hunger-state-dependent food-odour preference, and oxytocin-driven de novo synthesis of NPY5R via PKC/eEF2 signaling in the paraventricular nucleus is required for anxiolysis (PMID:33658716, PMID:30826070). In peripheral tissues, NPY5R couples to MAPK/ERK, PKA, and RhoA pathways to drive hepatic ApoA1 synthesis, granulosa cell proliferation, and cancer cell motility and metastasis—the latter through an autocrine NPY loop that is amplified under hypoxia via HIF-dependent transcriptional upregulation of NPY5R (PMID:35660638, PMID:31915051, PMID:40676141, PMID:35093384).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2003 High

    Determining whether NPY5R is individually required for NPY-driven feeding revealed functional redundancy with NPY1R, establishing that central orexigenic signaling does not depend on a single receptor subtype.

    Evidence Chronic ICV NPY infusion in Npy1r and Npy5r single-knockout mice with food intake and metabolic readouts

    PMID:14525913

    Open questions at the time
    • Double Npy1r/Npy5r knockout not tested
    • Downstream signaling pathways mediating feeding not dissected
    • Contribution of other NPY receptor subtypes not excluded
  2. 2008 Medium

    Pharmacological blockade of NPY5R in obese mice produced fat-selective weight loss confirmed on-target by Npy5r knockout controls, establishing NPY5R as a therapeutically relevant mediator of diet-induced obesity.

    Evidence Oral Y5 antagonist in diet-induced obese C57BL/6 vs. Npy5r−/− mice with body composition NMR and insulin tolerance tests

    PMID:18421274

    Open questions at the time
    • Mechanism of fat-selective weight loss not identified
    • Long-term efficacy and compensatory receptor upregulation not assessed
  3. 2013 High

    Demonstrating that NPY5R localizes to neuronal primary cilia via BBS-dependent trafficking linked ciliopathy-associated obesity to defective neuropeptide receptor signaling, showing that ciliary localization is required for PYY3-36-mediated satiety responses.

    Evidence GPCR localization screen, BBS and tubby mutant mouse models, c-fos activation, food intake, and cAMP signaling assays in ciliated vs. non-ciliated cells

    PMID:24316073

    Open questions at the time
    • Whether NPY5R signals exclusively from cilia or also from the plasma membrane not resolved
    • Structural basis of BBS-mediated ciliary targeting of NPY5R unknown
  4. 2016 Medium

    Development of a brain-penetrant PET radiotracer with specific striatal binding demonstrated that NPY5R is expressed and pharmacologically accessible in vivo in primate brain, enabling future occupancy studies.

    Evidence PET imaging in baboons with [18F]LuAE00654 and displacement by selective NPY5R antagonist

    PMID:26886507

    Open questions at the time
    • Regional receptor density quantification not performed
    • Translation to human imaging not yet demonstrated
  5. 2019 High

    Two studies revealed region-specific NPY5R roles: in the PVN, oxytocin drives de novo NPY5R synthesis via PKC/eEF2 to mediate anxiolysis; in the LHA, NPY5R becomes the dominant orexigenic receptor under high-fat diet conditions, resolving how diet alters NPY receptor subtype dependence.

    Evidence Intra-PVN agonist/antagonist infusion with eEF2/PKC pathway dissection and anxiety tests in rats; intra-LHA NPY infusion with subtype-selective antagonists in chow vs. high-fat-fed rats

    PMID:30826070 PMID:31887359

    Open questions at the time
    • Whether eEF2-dependent NPY5R synthesis occurs in other brain regions unknown
    • Molecular basis of diet-induced receptor subtype switching in LHA not identified
  6. 2020 Medium

    Electrophysiological dissection showed that NPY's direct inhibition of arcuate kisspeptin neurons is mediated by NPY1R, not NPY5R, delineating receptor subtype specificity in reproductive neuroendocrine circuits.

    Evidence Acute brain slice electrophysiology and calcium imaging in Kiss1-reporter mice with selective NPY1R/NPY5R antagonists and tetrodotoxin

    PMID:32337804

    Open questions at the time
    • Indirect NPY5R effects via presynaptic or network mechanisms not excluded
    • Only one hypothalamic cell type tested
  7. 2021 High

    Circuit-level dissection established that NPY5R in the paraventricular thalamus is the specific receptor required for hunger-state-dependent switching of olfactory valence, connecting metabolic state to sensory preference.

    Evidence Npy5r knockout mice, optogenetic AGRP neuron activation, cell-specific NPY rescue, and olfactory behavioral assays

    PMID:33658716

    Open questions at the time
    • Downstream intracellular signaling in thalamic neurons not characterized
    • Whether NPY5R modulates other sensory modalities unknown
  8. 2022 Medium

    Multiple studies defined peripheral NPY5R signaling: HIF-dependent transcriptional upregulation sensitizes breast cancer cells to NPY-driven MAPK/ERK signaling under hypoxia; NPY5R activates ERK1/2 and PKA to stimulate hepatic ApoA1 synthesis; and NPY5R forms a complex with NPY2R and NFATc1 in sebaceous glands linked to sebum gene regulation.

    Evidence ChIP for HIF at NPY5R locus plus MAPK assays in hypoxic breast cancer cells; hepatocyte cultures and rodent ApoA1 assays with pathway inhibitors; Co-IP/MS and ChIP-seq in sebaceous glands

    PMID:35093384 PMID:35660638 PMID:37501148

    Open questions at the time
    • Whether HIF-NPY5R axis operates in non-breast cancers not tested
    • ApoA1 regulation confirmed in cell lines and rodents but not in human hepatocytes
    • Functional consequence of NPY2R-NPY5R-NFATc1 complex for NPY5R signaling not determined
  9. 2023 Medium

    Pharmacological NPY5R blockade under hypoxia showed enhanced anti-proliferative and anti-migratory effects in breast cancer models, and combined NPY1R/NPY5R antagonism was additive, establishing NPY5R as a hypoxia-responsive oncogenic signaling node.

    Evidence NPY1R/NPY5R antagonists in 2D/3D breast cancer models with MAPK, migration, invasion, and spheroid assays; immunofluorescence of human breast tumor tissue

    PMID:37264315

    Open questions at the time
    • No in vivo tumor model with NPY5R antagonism
    • Correlation of NPY5R levels with patient outcome not established causally
  10. 2025 High

    CRISPR knockout of NPY5R in Ewing sarcoma xenografts eliminated extrapulmonary metastasis and identified RhoA activation via an autocrine NPY loop as the pro-metastatic mechanism, establishing a direct requirement for NPY5R in tumor dissemination.

    Evidence Inducible CRISPR/Cas9 NPY5R KO in SK-ES-1 xenografts, in vivo metastasis assays, RhoA activation assays, motility assays

    PMID:40676141

    Open questions at the time
    • Whether RhoA activation is direct or through intermediate effectors not resolved
    • Generalizability to other sarcoma or cancer types not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis of NPY5R coupling to divergent downstream effectors (Gi/o, MAPK/ERK, PKA, RhoA) in different cell types, and whether these reflect biased agonism or cell-context-dependent signaling complexes, remains unresolved.
  • No cryo-EM or crystal structure of NPY5R
  • No systematic comparison of G-protein vs. arrestin coupling
  • Mechanism by which ciliary vs. plasma membrane localization shapes signaling output unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 5
Localization
GO:0005886 plasma membrane 2 GO:0005929 cilium 1
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-112316 Neuronal System 4 R-HSA-1643685 Disease 3
Partners
DYRK1ANFATC1NPY2RRHOA
Complex memberships
NPY2R-NPY5R-NFATc1 complex

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 NPY5R localizes to neuronal primary cilia in hypothalamic neurons via the Bardet-Biedl syndrome (BBS) pathway; BBS mutant mice fail to localize NPY2R/NPY5R to cilia and fail to activate c-fos or decrease food intake in response to PYY3-36, demonstrating that ciliary targeting of NPY receptors is required for normal energy balance signaling. Comprehensive GPCR localization screen, mouse models of BBS and obese tubby mice, c-fos activation assay, food intake measurement, cAMP signaling assay in ciliary vs. non-ciliary cells Cell reports High 24316073
2021 NPY5R in the paraventricular thalamus mediates hunger-dependent food-odour attraction; mice lacking NPY5R fail to prefer food odours over pheromones after fasting, and acute NPY injection rescues this preference, indicating NPY acts through NPY5R to read olfactory circuits during behavioural expression. Npy5r knockout mice, optogenetic AGRP neuron activation, cell-specific NPY rescue, acute NPY injection, olfactory behavioural assays Nature High 33658716
2019 Oxytocin-induced upregulation of NPY5R protein in the paraventricular nucleus (PVN) is required for oxytocin's anxiolytic effect; NPY5R agonist infusion into the PVN reduces anxiety-like behaviour, and NPY5R antagonist pretreatment blocks oxytocin-induced anxiolysis. The mechanism involves oxytocin activating PKC-dependent eEF2 phosphorylation leading to de novo NPY5R protein synthesis. In vivo PVN infusion of NPY5R agonist/antagonist, hypothalamic cell line experiments, protein synthesis inhibition, eEF2 activation assays, anxiety behavioural tests in male rats Biological psychiatry High 30826070
2003 Chronic intracerebroventricular NPY infusion stimulates food intake and induces obesity in wild-type mice; the lack of either Npy1r or Npy5r alone does not prevent this feeding response, indicating biological redundancy between Y1 and Y5 receptor signaling in NPY-mediated control of food intake. Npy1r and Npy5r knockout mice, chronic lateral ventricle NPY infusion, food intake measurement, fat pad weight, plasma hormone levels, hypothalamic gene expression Endocrinology High 14525913
2022 NPY5R mRNA abundance is induced by hypoxia in a hypoxia-inducible factor (HIF)-dependent manner in breast cancer cells; HIFs bind genomic regions upstream of NPY5R transcription start sites, and NPY5R-stimulated MAPK/ERK signaling is more rapidly activated in hypoxic cells and is IGF1R-independent under hypoxia, rendering hypoxic cells more sensitive to NPY stimulation. ChIP for HIF binding at NPY5R promoter regions, MAPK/ERK signaling assays in normoxic vs. hypoxic cells, NPY5R agonist stimulation, IGF1R inhibitor experiments, cell proliferation and migration assays The Journal of biological chemistry High 35093384
2022 NPY5R activation promotes hepatic ApoA1 synthesis and secretion through ERK1/2 and PKA signal transduction pathways; NPY5R inhibition blocks NPY-induced ApoA1 upregulation and NPY5R agonist stimulates ApoA1 expression and secretion in hepatocytes in vitro and in vivo. In vivo NPY/NPY5R agonist injection in rodents, HepG2 and BRL-3A hepatocyte cultures with NPY receptor antagonists/agonists, ERK1/2 and PKA pathway inhibitors, ApoA1 protein and mRNA quantification Peptides Medium 35660638
2020 NPY directly suppresses neurokinin B-evoked firing of arcuate kisspeptin neurons through NPY1R (partially) but not NPY5R, as NPY5R antagonist L152,804 was ineffective while NPY1R antagonist BIBO 3304 partially blocked the suppression; this direct inhibitory effect was confirmed in the presence of tetrodotoxin, indicating post-synaptic direct action. Acute brain slice electrophysiology and calcium imaging in Kiss1-GFP and Kiss1-GCaMP6 mice, NPY1R and NPY5R selective antagonists, tetrodotoxin controls Journal of neuroendocrinology Medium 32337804
2019 NPY5R in the lateral hypothalamic area (LHA) mediates orexigenic effects of NPY on chow intake; NPY5R antagonism prevents intra-LHA NPY-induced feeding in both chow-fed and diet-induced obese (fcHFHS) rats, whereas NPY1R antagonism is effective only in chow-fed rats, indicating a diet-induced shift in LHA NPY receptor subtype dependence. Intra-LHA NPY infusion in chow vs. fcHFHS-fed rats, selective NPY1R and NPY5R antagonist co-administration, 2-hour food intake measurement with cross-over design Neuroscience Medium 31887359
2020 NPY5R mediates NPY-induced proliferation of early antral granulosa cells through the MEK signaling pathway; NPY5R antagonist (CGP71683) and MEK inhibitors (PD98059 and U0126) block NPY-induced Ki67-positive cell increase in early antral but not late antral follicles. Rat granulosa cell isolation from follicles at different stages, NPY treatment with NPY5R antagonist and MEK inhibitors, Ki67 proliferation assay, TUNEL apoptosis assay Journal of ovarian research Medium 31915051
2015 NPY stimulates autophagy in rodent hypothalamus via NPY1R or NPY5R activation, involving concerted action of multiple signaling pathways; NPY also mediates caloric restriction-induced autophagy in hypothalamic neurons. Rodent hypothalamic neuron cultures, receptor subtype pharmacology, autophagy assays Autophagy Low 26086271
2008 A selective Y5 receptor antagonist reduces body weight in diet-induced obese C57BL/6 mice but not in Npy5r knockout mice, confirming on-target specificity; the antagonist produced fat-selective body weight loss and ameliorated obesity-associated insulin resistance. Diet-induced obese C57BL/6 and Npy5r(-/-) mice, oral Y5 antagonist administration, body composition by NMR, insulin tolerance test, adipose tissue weights Obesity (Silver Spring, Md.) Medium 18421274
2023 NPY5R antagonism in hypoxia more greatly reduces MAPK signaling, cell proliferation, cell migration, invasion, and spheroid growth in breast cancer cells; combined NPY1R and NPY5R antagonism has additive anti-tumor effects, and NPY5R protein levels in human breast tumor tissue correlate with advanced cancer. NPY1R and NPY5R antagonists in 2D and 3D breast cancer cell models (MDA-MB-231 and MCF7), MAPK signaling assays, migration, proliferation, invasion assays, immunofluorescence of human tumor tissue BMC cancer Medium 37264315
2025 NPY5R is required for extrapulmonary metastasis of Ewing sarcoma; CRISPR/Cas9 knockout of NPY5R in SK-ES-1 xenografts eliminates metastases from NPY5R-null clones, and the underlying mechanism is NPY/Y5R-dependent RhoA activation driving cell motility via an autocrine NPY loop. Doxycycline-inducible CRISPR/Cas9 NPY5R knockout in xenografts, in vivo metastasis assays, in vitro cell motility assays, RhoA activation assays Oncogene High 40676141
2022 NPY2R forms a protein complex with NPY5R and NFATc1 in sebaceous glands; this complex is present at postnatal day 25 and is associated with DYRK1A-mediated NFATc1 phosphorylation (inactivation), while at PND-35 NFATc1 dephosphorylation and nuclear localization enables transcription of sebum-related genes. Immunoprecipitation, mass spectrometry, gel filtration, ChIP-seq for NFATc1, RNA sequencing, western blot, immunofluorescence Cellular & molecular biology letters Medium 37501148
2006 Human NPY5R was stably expressed as a functional receptor using IRES-based bicistronic vectors; the receptor displayed pharmacological properties consistent with reported NPY5R characteristics, enabling establishment of a stable cell line expressing active human NPY5R. Bicistronic vector expression in cell lines, radioligand binding, functional receptor assays Biochimie Low 16808994
2016 NPY5R PET radiotracer [18F]LuAE00654 penetrates the blood-brain barrier in baboons and shows specific in vivo binding in the striatum (highest NPY5R binding region), with up to 60% displacement by a specific NPY5R antagonist in blocking studies. PET imaging in anesthetized baboons, blocking studies with selective NPY5R antagonist, plasma metabolism analysis ACS chemical neuroscience Medium 26886507

Source papers

Stage 0 corpus · 88 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia. Cell reports 172 24316073
2006 Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell metabolism 139 17011500
2021 Hunger enhances food-odour attraction through a neuropeptide Y spotlight. Nature 71 33658716
2013 Genetic association analysis of 30 genes related to obesity in a European American population. International journal of obesity (2005) 67 23900445
2000 Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig. Genome research 65 10720571
2008 Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. Alcoholism, clinical and experimental research 64 18828811
2020 Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma. Scientific reports 63 32788609
2004 A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R. BMC medical genetics 63 15090072
2010 Transcriptional and pathway analysis in the hypothalamus of newly hatched chicks during fasting and delayed feeding. BMC genomics 60 20214824
2012 Meta-analysis of genome-wide association studies for panic disorder in the Japanese population. Translational psychiatry 50 23149450
2013 Quantity of glucose transporter and appetite-associated factor mRNA in various tissues after insulin injection in chickens selected for low or high body weight. Physiological genomics 42 24046279
2007 Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss. Obesity (Silver Spring, Md.) 41 17426325
2018 Genome-wide detection of selection signatures in Chinese indigenous Laiwu pigs revealed candidate genes regulating fat deposition in muscle. BMC genetics 40 29776331
2007 Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. Diabetes 40 17325259
2003 Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Endocrinology 38 14525913
2000 Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with obesity in Pima Indians. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 36 10849579
2015 Broiler chicken adipose tissue dynamics during the first two weeks post-hatch. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 35 26263851
2020 Direct inhibition of arcuate kisspeptin neurones by neuropeptide Y in the male and female mouse. Journal of neuroendocrinology 34 32337804
2020 Identification of Signatures of Selection by Whole-Genome Resequencing of a Chinese Native Pig. Frontiers in genetics 34 33093844
2014 Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. Oncogene 34 24681953
2015 Chronic administration of methamphetamine promotes atherosclerosis formation in ApoE-/- knockout mice fed normal diet. Atherosclerosis 32 26409626
2021 Effect of depression and suicidal behavior on neuropeptide Y (NPY) and its receptors in the adult human brain: A postmortem study. Progress in neuro-psychopharmacology & biological psychiatry 30 34411658
2018 Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction. Translational psychiatry 30 30135420
2009 Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. Journal of hypertension 30 19593212
2016 Association analysis between feed efficiency studies and expression of hypothalamic neuropeptide genes in laying ducks. Animal genetics 27 27329478
2021 Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus. Frontiers in endocrinology 25 34276562
2014 Identification of differentially expressed genes in hypothalamus of chicken during cold stress. Molecular biology reports 25 24407606
2011 Expression of Neuropeptide Y, Substance P, and their receptors in the right atrium of diabetic patients. Clinical and translational science 25 22029806
2007 NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine. Obesity (Silver Spring, Md.) 24 17712121
2019 De Novo Protein Synthesis Mediated by the Eukaryotic Elongation Factor 2 Is Required for the Anxiolytic Effect of Oxytocin. Biological psychiatry 22 30826070
2014 Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R. Journal of molecular medicine (Berlin, Germany) 22 24121255
2008 Effects of a novel Y5 antagonist in obese mice: combination with food restriction or sibutramine. Obesity (Silver Spring, Md.) 22 18421274
2015 NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging? Autophagy 21 26086271
2009 Long-term cognitive enrichment affects opioid receptor expression in the amygdala of domestic pigs. Genes, brain, and behavior 21 19804558
2023 Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling. BMC cancer 18 37264315
2020 Japanese Herbal Medicine Ninjinyoeito Mediates Its Orexigenic Properties Partially by Activating Orexin 1 Receptors. Frontiers in nutrition 17 32175325
2017 Genes encoding neuropeptide receptors are epigenetic markers in patients with head and neck cancer: a site-specific analysis. Oncotarget 16 29100314
2010 Characterization of an interstitial 4q32 deletion in a patient with mental retardation and a complex chromosome rearrangement. American journal of medical genetics. Part A 16 20358617
2005 Y1-receptors regulate the expression of Y2-receptors in distinct mouse forebrain areas. Neuroscience 16 16198492
2022 Genetic diversity and population structure of Tongcheng pigs in China using whole-genome SNP chip. Frontiers in genetics 14 36092902
2009 Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. PloS one 14 19759915
2022 Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation. The Journal of biological chemistry 13 35093384
2020 Neuropeptide Y regulates proliferation and apoptosis in granulosa cells in a follicular stage-dependent manner. Journal of ovarian research 13 31915051
2020 Dietary stevioside supplementation increases feed intake by altering the hypothalamic transcriptome profile and gut microbiota in broiler chickens. Journal of the science of food and agriculture 13 32981085
2020 Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 12 32057593
2020 Tumorigenesis-related key genes in adolescents and young adults with HR(+)/HER2(-) breast cancer. International journal of clinical and experimental pathology 11 33165441
2018 Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin. Pharmacogenomics 11 29465008
2018 Panic disorders: The role of genetics and epigenetics. AIMS genetics 11 31435520
2018 Effect of incubation temperature on neuropeptide Y and neuropeptide Y receptors in turkey and chicken satellite cells. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 10 29505887
2010 Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. BMB reports 10 20797317
2021 NPF activates a specific NPF receptor and regulates food intake in Pacific abalone Haliotis discus hannai. Scientific reports 9 34686694
2019 Neuropeptide Y Signaling in the Lateral Hypothalamus Modulates Diet Component Selection and is Dysregulated in a Model of Diet-Induced Obesity. Neuroscience 9 31887359
2023 Identification of candidate genes responsible for innate fear behavior in the chicken. G3 (Bethesda, Md.) 8 36454218
2016 Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. Journal of genetics and genomics = Yi chuan xue bao 8 27461754
2012 Candidate genes in ocular dominance plasticity. Frontiers in neuroscience 8 22347157
2006 The use of IRES-based bicistronic vectors allows the stable expression of recombinant G-protein coupled receptors such as NPY5 and histamine 4. Biochimie 8 16808994
2019 Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction. Journal of addiction medicine 7 30844877
2024 Comprehensive analysis of m6 A methylome and transcriptome by Nanopore sequencing in clear cell renal carcinoma. Molecular carcinogenesis 6 38362848
2023 The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis. Cellular & molecular biology letters 6 37501148
2022 The Novel Methylation Biomarker NPY5R Sensitizes Breast Cancer Cells to Chemotherapy. Frontiers in cell and developmental biology 6 35087836
2016 Radiosynthesis and in Vivo Evaluation of Neuropeptide Y5 Receptor (NPY5R) PET Tracers. ACS chemical neuroscience 6 26886507
2007 Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans. Obesity (Silver Spring, Md.) 6 17426313
2022 Correlation of Transcriptomics and FDG-PET SUVmax Indicates Reciprocal Expression of Stemness-Related Transcription Factor and Neuropeptide Signaling Pathways in Glucose Metabolism of Ewing Sarcoma. Cancers 5 36497479
1997 Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. Genomics 5 9417917
2023 Intermittent fasting disrupts hippocampal-dependent memory and norepinephrine content in aged male and female mice. Physiology & behavior 4 38072036
2022 Association of a Single-Nucleotide Variant rs11100494 of the NPY5R Gene with Antipsychotic-Induced Metabolic Disorders. Pharmaceutics 4 35213955
2022 Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor. Peptides 4 35660638
2019 Neuropeptide Y system mRNA expression changes in the hippocampus of a type I diabetes rat model. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 4 31563570
2011 Novel antigen design for the generation of antibodies to G-protein-coupled receptors. Journal of immunological methods 4 21605562
2025 Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway. Redox biology 3 40505347
2011 Analysis of multiple polymorphisms in the bovine neuropeptide Y5 receptor gene and structural modelling of the encoded protein. Molecular biology reports 3 21947839
2024 Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese. Frontiers in psychiatry 2 38487579
2022 A Variant in Genes of the NPY System as Modifier Factor of Machado-Joseph Disease in the Chinese Population. Frontiers in aging neuroscience 2 35185528
2022 Attenuation of the Counter-Regulatory Glucose Response in CVLM C1 Neurons: A Possible Explanation for Anorexia of Aging. Biomolecules 2 35327640
2020 The anorexigenic effect of beta-melanocyte-stimulating hormone involves corticotrophin-releasing factor and mesotocin in birds. Neuroscience letters 2 32738351
2016 Genetic expression analysis of E2F-associated phosphoprotein in stress responses in the mouse. Gene 2 26802973
2025 Targeted CRISPR approach reveals an essential role for neuropeptide Y receptor Y5 in Ewing sarcoma extrapulmonary metastasis. Oncogene 1 40676141
2025 Effects of amino acids methionine, lysine, and taurine on feed intake and mRNA expression of appetite-related neuropeptides in layer-type chicks. Poultry science 1 40743628
2024 The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity. Molecular and cellular endocrinology 1 39293775
2022 Identification of novel genetic and epigenetic regulators of different tissue types of cervical cancer. The journal of obstetrics and gynaecology research 1 36184073
2019 Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins. Experimental gerontology 1 31705967
2026 Tissue-Slice Organ-on-Chip Culture of Hypothalamic and Pituitary of Lambs─The Role of Phoenixin-20 as a Modulator of Gonadotrophic Axis. ACS biomaterials science & engineering 0 41508570
2026 Apelin-13 confers Neuropeptide Y-mediated neuroprotection and preserves learning and allocentric memory in D-glutamic acid-induced excitotoxicity in rats. Molecular neurobiology 0 41571878
2026 Targeting NPY5R-A Member of the NPY Receptor Family: Pharmacological and Transcriptomic Mechanisms of the Euphorbia Factor L2 Against Lung Adenocarcinoma. Pharmaceuticals (Basel, Switzerland) 0 41754862
2025 Central effects of bile acids on feed intake and mRNA expression of appetite-related neuropeptides in layer-type chicks. Poultry science 0 41265140
2025 Synergistic Anticancer and Certain Biochemical Events Impact ER+ MCF-7 Breast Cancer Cells by Local "Citrullus colocynthis-Lemon Fruit" Hydroethanolic Extract Combination. Asian Pacific journal of cancer prevention : APJCP 0 41459877
2024 Integrating Multiple Database Resources to Elucidate the Gene Flow in Southeast Asian Pig Populations. International journal of molecular sciences 0 38891877
2024 Therapeutic Potential of Propolis Extract in Managing Hyperinflammation and Long COVID-19: A Bioinformatics Study. Chemistry & biodiversity 0 39576127