Affinage

NPY5R

Neuropeptide Y receptor type 5 · UniProt Q15761

Length
445 aa
Mass
50.7 kDa
Annotated
2026-06-10
89 papers in source corpus 19 papers cited in narrative 19 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NPY5R is a neuropeptide Y receptor that operates across central energy-balance circuits, peripheral metabolic tissues, and tumor cell behavior, transducing NPY-family ligand signals into cAMP, MAPK/ERK, PKA, and RhoA outputs (PMID:24316073, PMID:35093384, PMID:40676141). In the hypothalamus, NPY5R traffics to neuronal primary cilia via the Bardet-Biedl syndrome (BBS) pathway, and this ciliary localization is required for augmented cAMP signaling and for the control of food intake (PMID:24316073). NPY5R mediates the orexigenic actions of NPY in the lateral hypothalamus and is required in the paraventricular thalamus for hunger-dependent attraction to food odors, with cell-specific NPY rescue in AGRP neurons restoring the behavior (PMID:33658716, PMID:31887359); pharmacological NPY5R antagonism reduces body weight and fat mass specifically through this receptor in diet-induced obese mice (PMID:18421274). NPY5R signaling shows functional redundancy with NPY1R in NPY-driven hyperphagia (PMID:14525913), and in the paraventricular nucleus NPY5R protein synthesis is upregulated by oxytocin through a PKC/eEF2 pathway to mediate anxiolysis (PMID:30826070). Peripherally, NPY5R drives hepatic ApoA1 synthesis through ERK1/2 and PKA (PMID:35660638) and stimulates early-antral granulosa cell proliferation via the MEK pathway (PMID:31915051). In cancer, hypoxia induces NPY5R transcription in a HIF-dependent manner to sensitize MAPK/ERK signaling and promote breast cancer proliferation, migration, and invasion (PMID:35093384, PMID:37264315), while autocrine NPY/NPY5R signaling drives RhoA-dependent cell motility and extrapulmonary metastasis in Ewing sarcoma (PMID:40676141). NPY5R also assembles into a protein complex with NPY2R and NFATc1 in sebaceous gland tissue (PMID:37501148).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2003 High

    Establishing whether Y1 and Y5 receptors carry independent or overlapping roles in NPY-driven feeding determined how redundantly the NPY orexigenic system is wired.

    Evidence Chronic intracerebroventricular NPY infusion in Npy1r- and Npy5r-knockout mice with food intake and body composition readouts

    PMID:14525913

    Open questions at the time
    • Does not resolve which receptor dominates under acute or physiological NPY tone
    • Redundancy mechanism at the cellular/circuit level not defined
  2. 2008 High

    Demonstrating that a Y5 antagonist loses efficacy in Npy5r-null mice confirmed on-target pharmacology and validated NPY5R as a weight-control target.

    Evidence Selective Y5 antagonist in wild-type versus Npy5r-knockout diet-induced obese mice with body composition and insulin tolerance readouts

    PMID:18421274

    Open questions at the time
    • Downstream signaling mediating weight loss not dissected
    • Site of antagonist action not localized
  3. 2013 High

    Identifying that NPY5R requires BBS-dependent trafficking to neuronal primary cilia revealed a subcellular compartment essential for its energy-balance signaling.

    Evidence GPCR localization imaging in BBS and tubby mutant mice with cAMP, c-fos, and food intake readouts

    PMID:24316073

    Open questions at the time
    • Direct ciliary localization of NPY5R is inferred from NPY2R rather than shown directly
    • Molecular adaptors targeting NPY5R to cilia not identified
  4. 2016 Medium

    Demonstrating in vivo radioligand target engagement at NPY5R in the primate brain confirmed receptor expression and druggability in the CNS.

    Evidence [18F]LuAE00654 PET in baboons with selective antagonist blocking

    PMID:26886507

    Open questions at the time
    • Cell types expressing striatal NPY5R not defined
    • Functional role of striatal receptor not addressed
  5. 2019 Medium

    Showing that LHA NPY5R is selectively required for NPY orexigenic effects under obesogenic diet identified a diet-induced shift in receptor dependence.

    Evidence Intra-LHA receptor-selective antagonism in chow-fed versus diet-induced obese rats

    PMID:31887359

    Open questions at the time
    • Molecular basis of the receptor-sensitivity switch unknown
    • Single-lab pharmacological dissection
  6. 2019 Medium

    Linking oxytocin-induced NPY5R protein synthesis to anxiolysis connected NPY5R to emotional regulation downstream of a PKC/eEF2 translational pathway.

    Evidence OXT treatment with PVN NPY5R agonist/antagonist infusion, protein synthesis inhibition, and anxiety behavioral assays

    PMID:30826070

    Open questions at the time
    • Direct demonstration of eEF2-dependent NPY5R translation incomplete
    • Neuronal population responsible not identified
  7. 2020 Medium

    Mapping the peripheral and reproductive actions of NPY5R extended its role beyond feeding to granulosa cell proliferation via MEK.

    Evidence In vitro granulosa cell NPY5R antagonist plus MEK inhibitor treatment with proliferation and apoptosis assays

    PMID:31915051

    Open questions at the time
    • Mechanism of opposing late-follicle effect not via NPY5R defined
    • In vivo relevance not established
  8. 2020 Medium

    A negative pharmacological result clarified that NPY5R does not mediate NPY's direct inhibition of arcuate kisspeptin neurons, delimiting its circuit specificity.

    Evidence Brain slice electrophysiology and calcium imaging with NPY1R/NPY5R antagonists and TTX in Kiss1 reporter mice

    PMID:32337804

    Open questions at the time
    • Does not exclude indirect NPY5R contributions
    • Single-lab electrophysiology
  9. 2020 Low

    Identifying leptin-dependent regulation of adipose NPY5R suggested feedback between adiposity signals and receptor abundance.

    Evidence Leptin treatment of cultured adipocytes and Lepr-deficient ZSF1 rats with Western blot readout

    PMID:39293775

    Open questions at the time
    • Mechanism of leptin regulation not dissected
    • Functional consequence of adipose NPY5R changes unknown
  10. 2021 High

    Demonstrating that NPY5R in the paraventricular thalamus is required for hunger-dependent food-odor attraction defined its role in gating behavioral readout of olfactory circuits.

    Evidence NPY5R-knockout mice with optogenetic AGRP activation, cell-specific NPY rescue, and olfactory preference assays

    PMID:33658716

    Open questions at the time
    • Downstream signaling in PVT neurons not detailed
    • Whether ciliary trafficking is involved here untested
  11. 2022 Medium

    Showing HIF-dependent transcriptional induction of NPY5R in hypoxic cancer cells revealed a microenvironmental input that amplifies MAPK/ERK signaling.

    Evidence HIF ChIP at NPY5R loci, MAPK assays, and IGF1R inhibition in breast cancer cells

    PMID:35093384

    Open questions at the time
    • IGF1R-independent hypoxic signaling mechanism not fully resolved
    • Single cancer-cell context
  12. 2022 Medium

    Defining the hepatic ERK1/2 and PKA dependence of NPY5R-driven ApoA1 synthesis placed the receptor in lipoprotein metabolism.

    Evidence In vivo and in vitro hepatocyte NPY5R agonist/antagonist treatment with pathway inhibitors and ApoA1 measurement

    PMID:35660638

    Open questions at the time
    • Physiological context of hepatic NPY5R signaling unclear
    • Single-lab pharmacology
  13. 2022 Medium

    Identifying the NPY2R/NPY5R/NFATc1 complex in sebaceous tissue revealed a biochemical assembly linking NPY5R to NFAT-controlled transcription.

    Evidence Immunoprecipitation, mass spectrometry, gel filtration, ChIP-seq, and RNA-seq in rat volar tissue

    PMID:37501148

    Open questions at the time
    • Direct NPY5R-NFATc1 contact versus indirect assembly not resolved
    • Signaling that nucleates the complex not defined
  14. 2022 Low

    Reporting NPY5R as an epigenetically silenced tumor suppressor in breast cancer raised a context-dependent anti-growth role opposite to its pro-tumor signaling elsewhere.

    Evidence Methylation analysis, ectopic NPY5R expression, growth/apoptosis/cell-cycle assays, and IL6 co-IP

    PMID:35087836

    Open questions at the time
    • IL6/STAT3 mechanism rests on interaction data without dissection
    • Overexpression artifact not excluded
    • Conflicts with pro-invasive role in same tumor type
  15. 2023 Medium

    Functional antagonism in 2D and 3D breast cancer models established that NPY5R signaling supports proliferation, migration, and invasion under hypoxia.

    Evidence Receptor-selective antagonists with migration/invasion/spheroid assays and tumor immunofluorescence

    PMID:37264315

    Open questions at the time
    • In vivo metastasis contribution not tested in this system
    • Reconciliation with tumor-suppressor report unresolved
  16. 2025 High

    CRISPR knockout in Ewing sarcoma xenografts pinned NPY5R as a driver of extrapulmonary metastasis through RhoA-dependent motility, providing causal in vivo evidence.

    Evidence Doxycycline-inducible CRISPR NPY5R knockout xenografts with in vivo metastasis assays, clonal analysis, and in vitro RhoA activation

    PMID:40676141

    Open questions at the time
    • G-protein coupling linking NPY5R to RhoA not delineated
    • Determinants of extrapulmonary niche tropism unknown
  17. 2024 Low

    A co-segregating deleterious NPY5R variant in an OCD pedigree raised a candidate role in obsessive-compulsive disorder.

    Evidence Whole-genome sequencing and Bayesian co-segregation analysis in multiplex OCD pedigrees (preprint)

    PMID:42078338

    Open questions at the time
    • No functional validation of the variant
    • Single pedigree, preprint
    • Causal mechanism unestablished

Open questions

Synthesis pass · forward-looking unresolved questions
  • The G-protein coupling and downstream effector logic that lets NPY5R select among cAMP, MAPK/ERK, PKA, and RhoA outputs in different tissues, and the reconciliation of its opposing pro-tumor and tumor-suppressor roles, remain unresolved.
  • No structural model of NPY5R in the corpus
  • Mechanism dictating tissue-specific effector choice unknown
  • Conflicting cancer roles not resolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 4 GO:0048018 receptor ligand activity 2
Localization
GO:0005886 plasma membrane 2 GO:0005929 cilium 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-1430728 Metabolism 2 R-HSA-1643685 Disease 2
Partners
IL6NFATC1NPYNPY2R
Complex memberships
NPY2R/NPY5R/NFATc1 complex

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 NPY5R (and NPY2R) localizes to neuronal primary cilia in the hypothalamus via the Bardet-Biedl syndrome (BBS) trafficking pathway. BBS mutant mice and obese tubby mice fail to localize NPY2R (and implicitly NPY5R) to cilia, and ciliary NPY receptor localization is required for augmented cAMP signaling and for controlling energy balance responses (c-fos activation, food intake reduction) to PYY3-36. Comprehensive GPCR localization screen (imaging), mouse genetic models of BBS and tubby mutations, cAMP signaling assays, c-fos activation, food intake measurements Cell Reports High 24316073
2021 NPY5R is required in the paraventricular thalamus for hunger-dependent attraction to food odors. Mice lacking NPY5R (or NPY) fail to prefer food odors over pheromones after fasting. Acute NPY injection rescues food-odor preference, indicating NPY5R mediates reading of olfactory circuits during behavioral expression rather than during odor learning. Cell-specific NPY rescue in AGRP neurons restored the effect. NPY5R knockout mice, optogenetic activation of AGRP neurons, branch-specific activation/inhibition of hypothalamic projections, acute NPY injection, behavioral olfactory preference assays Nature High 33658716
2003 Genetic epistasis experiment: chronic central (lateral ventricle) NPY infusion in mice lacking either Npy1r or Npy5r (knockout) still produces sustained hyperphagia and obesity indistinguishable from wild-type, indicating biological redundancy between Y1 and Y5 receptor signaling in NPY-mediated control of food intake. Npy1r and Npy5r knockout mice, chronic intracerebroventricular NPY infusion, food intake measurement, body composition, plasma hormone levels Endocrinology High 14525913
2008 Selective NPY5R antagonist (spironolactone Y5 antagonist) reduces body weight and fat mass in diet-induced obese (DIO) C57BL/6 mice but has no effect in Npy5r-knockout DIO mice, demonstrating that the weight-loss effect is specifically mediated through the Y5 receptor. The antagonist also ameliorated obesity-associated insulin resistance. Npy5r knockout mice versus wild-type DIO mice, pharmacological Y5 antagonist treatment, body weight, body composition (NMR), insulin tolerance test, adipose tissue weights Obesity High 18421274
2019 In the lateral hypothalamic area (LHA), the orexigenic effects of NPY are mediated by both NPY1R and NPY5R in chow-fed rats, but specifically by NPY5R (not NPY1R) antagonism in diet-induced obese (fcHFHS) rats, demonstrating that LHA NPY5R sensitivity is selectively dysregulated during obesogenic diet consumption. Intra-LHA NPY infusion, pharmacological antagonism of NPY1R and NPY5R in chow-fed and diet-induced obese (fcHFHS) rats, diet component intake measurement Neuroscience Medium 31887359
2019 OXT (oxytocin) upregulates NPY5R protein synthesis in the paraventricular nucleus (PVN) via a protein kinase C-dependent eEF2 activation pathway, and NPY5R activation in the PVN mediates the anxiolytic effect of OXT. A specific NPY5R agonist infused into the PVN decreased anxiety, and NPY5R antagonist pretreatment blocked OXT's anxiolytic effect. In vivo and cell culture experiments with OXT and eEF2, NPY5R agonist and antagonist infusion into PVN, anxiety behavioral assays, protein synthesis inhibition experiments Biological Psychiatry Medium 30826070
2022 NPY5R stimulation in hepatocytes promotes ApoA1 synthesis and secretion through ERK1/2 and PKA signal transduction pathways. NPY5R inhibition blocked NPY-induced ApoA1 upregulation, and NPY5R agonist activation stimulated ApoA1 expression and secretion both in vivo and in vitro. In vivo NPY/NPY5R agonist injection in mice, in vitro HepG2 and BRL-3A hepatocyte treatment with NPY receptor antagonists, agonists, ERK1/2 and PKA inhibitors; ApoA1 protein and mRNA measurement Peptides Medium 35660638
2022 NPY1R and NPY5R mRNA abundance is induced by hypoxia in a hypoxia-inducible factor (HIF)-dependent manner in breast cancer cells (MCF7 and MDA-MB-231). HIFs bind to genomic regions upstream of NPY5R transcription start sites. Hypoxia-induced NPY5R sensitizes cells to NPY stimulation, leading to more rapid MAPK/ERK activation; this pathway requires IGF1R in normoxia but not in hypoxic cells. HIF-dependent hypoxia induction, chromatin immunoprecipitation (ChIP) for HIF binding at NPY5R loci, MAPK/ERK signaling assays, IGF1R inhibitor treatment, cell proliferation and migration assays Journal of Biological Chemistry Medium 35093384
2023 Pharmacological antagonism of NPY5R (and NPY1R) in hypoxic breast cancer cells reduces MAPK signaling, cell proliferation, migration, invasion, and spheroid growth. NPY5R antagonism specifically inhibited invasion of estrogen receptor-positive MCF7 cells in 3D spheres, demonstrating functional relevance of NPY5R signaling in breast cancer cell behavior. NPY5R-selective and NPY1R-selective antagonists in 2D and 3D breast cancer models, cell migration/invasion assays, MAPK signaling, immunofluorescence for NPY5R protein in human tumor tissue BMC Cancer Medium 37264315
2020 NPY directly suppresses neurokinin B-evoked firing of approximately half of arcuate kisspeptin neurons; this suppression is partially blocked by NPY1R antagonist BIBO 3304, but the NPY5R antagonist L152,804 was ineffective. The inhibitory effect persists in the presence of tetrodotoxin and amino acid receptor antagonists, indicating direct post-synaptic action. Thus, NPY5R does not mediate NPY's direct inhibitory effect on arcuate kisspeptin neurons. Acute brain slice electrophysiology, calcium imaging in Kiss1-GFP and Kiss1-GCaMP6 mice, pharmacological antagonism with NPY1R and NPY5R selective antagonists, TTX and amino acid receptor blockers Journal of Neuroendocrinology Medium 32337804
2020 Leptin (1 nM and 10 nM) selectively reduces NPY5R protein levels in cultured adipocytes, but does not similarly affect other NPYR or MCR subtypes. In Lepr-deficient (ZSF1) rats, NPY5R levels are reduced, suggesting leptin signaling positively regulates NPY5R expression in adipose tissue. Cultured adipocyte treatment with leptin, Western blot for NPY5R and other receptors, ZSF1 leptin receptor-deficient rat model Molecular and Cellular Endocrinology Low 39293775
2016 In vivo PET studies in baboons using [18F]LuAE00654 demonstrated that NPY5R is expressed in the brain, that the radioligand penetrates the blood-brain barrier and is retained in the brain (highest in striatum), and that up to 60% displacement of radioactivity in striatum was achieved by blocking with a specific NPY5R antagonist, confirming in vivo target engagement of NPY5R. PET imaging in anesthetized baboons with [18F]LuAE00654, blocking studies with selective NPY5R antagonist ACS Chemical Neuroscience Medium 26886507
2022 NPY5R forms a protein complex with NPY2R and NFATc1 in sebaceous glands. Immunoprecipitation, mass spectrometry, and gel filtration identified the NPY2R/NPY5R/NFATc1 complex in pre-pubertal rat volar tissue. This complex is associated with DYRK1A-mediated NFATc1 phosphorylation status controlling sebum-related gene transcription. Immunoprecipitation, mass spectrometry, gel filtration, western blot, immunofluorescence, chromatin immunoprecipitation sequencing (ChIP-seq), RNA sequencing Cellular & Molecular Biology Letters Medium 37501148
2022 NPY5R expression is frequently downregulated in breast cancer due to aberrant promoter CpG methylation. Ectopic NPY5R expression curbs breast tumor cell growth, induces apoptosis and G2/M arrest, and promotes doxorubicin sensitivity. Mechanistically, NPY5R restricts STAT3 signaling pathway activation through interaction with IL6. Weighted gene co-expression network analysis, methylation analysis, demethylation agent treatment, ectopic NPY5R expression, cell growth/apoptosis/cell cycle assays, doxorubicin sensitivity assay, gene set enrichment analysis, co-immunoprecipitation/interaction assay with IL6 Frontiers in Cell and Developmental Biology Low 35087836
2020 NPY granulosa cell proliferation in early antral follicles is mediated through NPY5R and the MEK signaling pathway. Treatment with NPY5R antagonist (CGP71683) and MEK inhibitors (PD98059 and U0126) blocked NPY-induced proliferation in early antral granulosa cells. In contrast, in late antral follicles, NPY reduces proliferation and increases apoptosis via a different mechanism. In vitro granulosa cell treatment with NPY5R antagonist and MEK inhibitors, Ki67-positivity assays for proliferation, TUNEL assays for apoptosis, receptor expression by PCR and western blot Journal of Ovarian Research Medium 31915051
2025 CRISPR/Cas9 knockout of NPY5R (Y5R) in Ewing sarcoma SK-ES-1 xenografts demonstrated that metastases to extrapulmonary niches (including bone) develop exclusively from clones retaining a functional NPY5R gene. Wild-type xenografts showed selection for clones with NPY5R gene gain in metastatic lesions. In vitro assays identified Y5R-dependent RhoA activation as the mechanism driving NPY-stimulated ES cell motility underlying the metastatic phenotype. Autocrine NPY/Y5R signaling maintains basal cell motility in NPY-secreting ES cell lines. Doxycycline-inducible CRISPR/Cas9 NPY5R knockout in xenografts, in vivo metastasis assays, in vitro cell motility assays, RhoA activation assays Oncogene High 40676141
2006 Stable cell lines expressing functional human NPY5R were successfully established using IRES-based bicistronic vectors (with EMCV, VEGF, FGF1A or FGF2 IRES), allowing pharmacological characterization of the receptor. The receptor expressed by these cells retained pharmacological properties consistent with the literature, enabling receptor-ligand binding and functional characterization. IRES-based bicistronic vector expression, flow cytometry, receptor-ligand binding assays for functional validation of NPY5R-expressing cell lines Biochimie Low 16808994
2015 NPY stimulates autophagy in rodent hypothalamic neurons and mediates caloric restriction-induced autophagy in hypothalamic neurons through activation of NPY1R or NPY5R, involving coordinated action of multiple signaling pathways. Rodent hypothalamic neuron cultures, NPY1R/NPY5R pharmacological manipulation, autophagy assays (described in referenced prior work, summarized here) Autophagy Low 26086271
2024 A rare highly deleterious missense variant in NPY5R co-segregates with OCD in the majority of affected individuals in a multiplex OCD pedigree, identified by whole-genome sequencing and Bayesian pathogenicity/co-segregation analysis. Whole-genome sequencing of 25 individuals in two multiplex OCD pedigrees, Bayesian inference incorporating variant pathogenicity and co-segregation medRxivpreprint Low 42078338

Source papers

Stage 0 corpus · 89 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia. Cell reports 174 24316073
2006 Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell metabolism 140 17011500
2021 Hunger enhances food-odour attraction through a neuropeptide Y spotlight. Nature 73 33658716
2013 Genetic association analysis of 30 genes related to obesity in a European American population. International journal of obesity (2005) 67 23900445
2008 Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. Alcoholism, clinical and experimental research 65 18828811
2000 Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig. Genome research 65 10720571
2020 Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma. Scientific reports 64 32788609
2004 A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R. BMC medical genetics 64 15090072
2010 Transcriptional and pathway analysis in the hypothalamus of newly hatched chicks during fasting and delayed feeding. BMC genomics 61 20214824
2012 Meta-analysis of genome-wide association studies for panic disorder in the Japanese population. Translational psychiatry 50 23149450
2013 Quantity of glucose transporter and appetite-associated factor mRNA in various tissues after insulin injection in chickens selected for low or high body weight. Physiological genomics 42 24046279
2007 Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss. Obesity (Silver Spring, Md.) 41 17426325
2018 Genome-wide detection of selection signatures in Chinese indigenous Laiwu pigs revealed candidate genes regulating fat deposition in muscle. BMC genetics 40 29776331
2007 Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. Diabetes 40 17325259
2003 Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Endocrinology 38 14525913
2000 Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with obesity in Pima Indians. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 36 10849579
2020 Direct inhibition of arcuate kisspeptin neurones by neuropeptide Y in the male and female mouse. Journal of neuroendocrinology 35 32337804
2015 Broiler chicken adipose tissue dynamics during the first two weeks post-hatch. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 35 26263851
2020 Identification of Signatures of Selection by Whole-Genome Resequencing of a Chinese Native Pig. Frontiers in genetics 34 33093844
2014 Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. Oncogene 34 24681953
2015 Chronic administration of methamphetamine promotes atherosclerosis formation in ApoE-/- knockout mice fed normal diet. Atherosclerosis 32 26409626
2021 Effect of depression and suicidal behavior on neuropeptide Y (NPY) and its receptors in the adult human brain: A postmortem study. Progress in neuro-psychopharmacology & biological psychiatry 30 34411658
2018 Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction. Translational psychiatry 30 30135420
2009 Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. Journal of hypertension 30 19593212
2016 Association analysis between feed efficiency studies and expression of hypothalamic neuropeptide genes in laying ducks. Animal genetics 28 27329478
2021 Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus. Frontiers in endocrinology 25 34276562
2014 Identification of differentially expressed genes in hypothalamus of chicken during cold stress. Molecular biology reports 25 24407606
2011 Expression of Neuropeptide Y, Substance P, and their receptors in the right atrium of diabetic patients. Clinical and translational science 25 22029806
2007 NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine. Obesity (Silver Spring, Md.) 24 17712121
2014 Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R. Journal of molecular medicine (Berlin, Germany) 23 24121255
2019 De Novo Protein Synthesis Mediated by the Eukaryotic Elongation Factor 2 Is Required for the Anxiolytic Effect of Oxytocin. Biological psychiatry 22 30826070
2008 Effects of a novel Y5 antagonist in obese mice: combination with food restriction or sibutramine. Obesity (Silver Spring, Md.) 22 18421274
2015 NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging? Autophagy 21 26086271
2009 Long-term cognitive enrichment affects opioid receptor expression in the amygdala of domestic pigs. Genes, brain, and behavior 21 19804558
2023 Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling. BMC cancer 20 37264315
2020 Japanese Herbal Medicine Ninjinyoeito Mediates Its Orexigenic Properties Partially by Activating Orexin 1 Receptors. Frontiers in nutrition 18 32175325
2017 Genes encoding neuropeptide receptors are epigenetic markers in patients with head and neck cancer: a site-specific analysis. Oncotarget 16 29100314
2010 Characterization of an interstitial 4q32 deletion in a patient with mental retardation and a complex chromosome rearrangement. American journal of medical genetics. Part A 16 20358617
2005 Y1-receptors regulate the expression of Y2-receptors in distinct mouse forebrain areas. Neuroscience 16 16198492
2022 Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation. The Journal of biological chemistry 15 35093384
2020 Neuropeptide Y regulates proliferation and apoptosis in granulosa cells in a follicular stage-dependent manner. Journal of ovarian research 15 31915051
2009 Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. PloS one 15 19759915
2022 Genetic diversity and population structure of Tongcheng pigs in China using whole-genome SNP chip. Frontiers in genetics 14 36092902
2020 Dietary stevioside supplementation increases feed intake by altering the hypothalamic transcriptome profile and gut microbiota in broiler chickens. Journal of the science of food and agriculture 13 32981085
2020 Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 12 32057593
2020 Tumorigenesis-related key genes in adolescents and young adults with HR(+)/HER2(-) breast cancer. International journal of clinical and experimental pathology 11 33165441
2018 Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin. Pharmacogenomics 11 29465008
2018 Panic disorders: The role of genetics and epigenetics. AIMS genetics 11 31435520
2018 Effect of incubation temperature on neuropeptide Y and neuropeptide Y receptors in turkey and chicken satellite cells. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 10 29505887
2010 Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. BMB reports 10 20797317
2021 NPF activates a specific NPF receptor and regulates food intake in Pacific abalone Haliotis discus hannai. Scientific reports 9 34686694
2019 Neuropeptide Y Signaling in the Lateral Hypothalamus Modulates Diet Component Selection and is Dysregulated in a Model of Diet-Induced Obesity. Neuroscience 9 31887359
2023 Identification of candidate genes responsible for innate fear behavior in the chicken. G3 (Bethesda, Md.) 8 36454218
2016 Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. Journal of genetics and genomics = Yi chuan xue bao 8 27461754
2012 Candidate genes in ocular dominance plasticity. Frontiers in neuroscience 8 22347157
2006 The use of IRES-based bicistronic vectors allows the stable expression of recombinant G-protein coupled receptors such as NPY5 and histamine 4. Biochimie 8 16808994
2024 Comprehensive analysis of m6 A methylome and transcriptome by Nanopore sequencing in clear cell renal carcinoma. Molecular carcinogenesis 7 38362848
2019 Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction. Journal of addiction medicine 7 30844877
2023 The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis. Cellular & molecular biology letters 6 37501148
2022 The Novel Methylation Biomarker NPY5R Sensitizes Breast Cancer Cells to Chemotherapy. Frontiers in cell and developmental biology 6 35087836
2016 Radiosynthesis and in Vivo Evaluation of Neuropeptide Y5 Receptor (NPY5R) PET Tracers. ACS chemical neuroscience 6 26886507
2007 Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans. Obesity (Silver Spring, Md.) 6 17426313
2022 Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor. Peptides 5 35660638
2022 Correlation of Transcriptomics and FDG-PET SUVmax Indicates Reciprocal Expression of Stemness-Related Transcription Factor and Neuropeptide Signaling Pathways in Glucose Metabolism of Ewing Sarcoma. Cancers 5 36497479
1997 Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. Genomics 5 9417917
2023 Intermittent fasting disrupts hippocampal-dependent memory and norepinephrine content in aged male and female mice. Physiology & behavior 4 38072036
2022 Association of a Single-Nucleotide Variant rs11100494 of the NPY5R Gene with Antipsychotic-Induced Metabolic Disorders. Pharmaceutics 4 35213955
2019 Neuropeptide Y system mRNA expression changes in the hippocampus of a type I diabetes rat model. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 4 31563570
2011 Novel antigen design for the generation of antibodies to G-protein-coupled receptors. Journal of immunological methods 4 21605562
2025 Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway. Redox biology 3 40505347
2011 Analysis of multiple polymorphisms in the bovine neuropeptide Y5 receptor gene and structural modelling of the encoded protein. Molecular biology reports 3 21947839
2024 Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese. Frontiers in psychiatry 2 38487579
2022 A Variant in Genes of the NPY System as Modifier Factor of Machado-Joseph Disease in the Chinese Population. Frontiers in aging neuroscience 2 35185528
2022 Attenuation of the Counter-Regulatory Glucose Response in CVLM C1 Neurons: A Possible Explanation for Anorexia of Aging. Biomolecules 2 35327640
2020 The anorexigenic effect of beta-melanocyte-stimulating hormone involves corticotrophin-releasing factor and mesotocin in birds. Neuroscience letters 2 32738351
2016 Genetic expression analysis of E2F-associated phosphoprotein in stress responses in the mouse. Gene 2 26802973
2026 Apelin-13 confers Neuropeptide Y-mediated neuroprotection and preserves learning and allocentric memory in D-glutamic acid-induced excitotoxicity in rats. Molecular neurobiology 1 41571878
2025 Targeted CRISPR approach reveals an essential role for neuropeptide Y receptor Y5 in Ewing sarcoma extrapulmonary metastasis. Oncogene 1 40676141
2025 Effects of amino acids methionine, lysine, and taurine on feed intake and mRNA expression of appetite-related neuropeptides in layer-type chicks. Poultry science 1 40743628
2024 Integrating Multiple Database Resources to Elucidate the Gene Flow in Southeast Asian Pig Populations. International journal of molecular sciences 1 38891877
2024 The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity. Molecular and cellular endocrinology 1 39293775
2022 Identification of novel genetic and epigenetic regulators of different tissue types of cervical cancer. The journal of obstetrics and gynaecology research 1 36184073
2019 Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins. Experimental gerontology 1 31705967
2026 Tissue-Slice Organ-on-Chip Culture of Hypothalamic and Pituitary of Lambs─The Role of Phoenixin-20 as a Modulator of Gonadotrophic Axis. ACS biomaterials science & engineering 0 41508570
2026 Targeting NPY5R-A Member of the NPY Receptor Family: Pharmacological and Transcriptomic Mechanisms of the Euphorbia Factor L2 Against Lung Adenocarcinoma. Pharmaceuticals (Basel, Switzerland) 0 41754862
2026 Rare protein-disrupting variants in NPY5R, DLGAP1 and MAPK8IP3 segregate with OCD in two multiplex pedigrees. medRxiv : the preprint server for health sciences 0 42078338
2025 Central effects of bile acids on feed intake and mRNA expression of appetite-related neuropeptides in layer-type chicks. Poultry science 0 41265140
2025 Synergistic Anticancer and Certain Biochemical Events Impact ER+ MCF-7 Breast Cancer Cells by Local "Citrullus colocynthis-Lemon Fruit" Hydroethanolic Extract Combination. Asian Pacific journal of cancer prevention : APJCP 0 41459877
2024 Therapeutic Potential of Propolis Extract in Managing Hyperinflammation and Long COVID-19: A Bioinformatics Study. Chemistry & biodiversity 0 39576127

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