Affinage

NPY1R

Neuropeptide Y receptor type 1 · UniProt P25929

Length
384 aa
Mass
44.4 kDa
Annotated
2026-04-29
38 papers in source corpus 16 papers cited in narrative 18 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NPY1R is a Gi/o-coupled receptor for neuropeptide Y (NPY) and peptide YY (PYY) that transduces inhibitory signals across diverse neuronal, adipocyte, epithelial, and immune cell types to regulate energy homeostasis, pain processing, anxiety, behavioral flexibility, and gut function. In the central nervous system, NPY1R on forebrain excitatory neurons controls HPA axis activity, body weight, and white adipose tissue mass in a sex-dependent manner (PMID:32755609), gates neuropathic pain via spinal dorsal horn Grp/Npy1r interneurons that synergize with opioid analgesia (PMID:37824208, PMID:41738433), and regulates orbitofrontal serotonergic tone to support behavioral flexibility (PMID:29353053). In peripheral tissues, NPY1R suppresses lipolysis through cAMP attenuation in adipocytes (PMID:41412283), marks LGR5+ colorectal stem cells that serve as a cell of origin for colon cancer upon Wnt pathway dysregulation (PMID:40897804), and its promoter is epigenetically silenced by DNMT recruitment via UHRF1 or the lncRNA MCM3AP-AS1, linking NPY1R expression levels to intestinal barrier integrity and prostate cancer progression (PMID:41657307, PMID:32193153).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2003 High

    Establishing that Y1 and Y5 receptors are functionally redundant for NPY-driven hyperphagia resolved whether either receptor alone was indispensable for central feeding control.

    Evidence Chronic ICV NPY infusion in Npy1r-KO and Npy5r-KO mice showing preserved hyperphagia and obesity in both lines

    PMID:14525913

    Open questions at the time
    • Downstream signaling pathways mediating redundancy not defined
    • Brain region-specific versus global KO contributions unresolved
  2. 2018 High

    Demonstrating that NPY1R loss in Y5R-co-expressing neurons impairs reversal learning and reduces OFC serotonergic innervation established NPY1R as a regulator of cognitive flexibility through serotonergic circuits.

    Evidence Conditional Npy1rY5R-/- KO mice with reversal learning tasks, 5-HT fiber quantification, c-Fos mapping, and escitalopram rescue

    PMID:29353053

    Open questions at the time
    • Mechanism by which NPY1R regulates serotonergic fiber density unknown
    • Whether cognitive deficits are developmental or acute not determined
  3. 2020 High

    Conditional forebrain excitatory neuron Npy1r deletion revealed sex-dependent roles in HPA axis regulation, anxiety, and adiposity, establishing NPY1R as a node integrating energy homeostasis with stress circuitry in a sexually dimorphic manner.

    Evidence Conditional KO (Npy1rrfb) mice with behavioral, endocrine, and metabolic phenotyping; AgRP immunohistochemistry

    PMID:32755609

    Open questions at the time
    • Estrogen-dependent compensatory mechanisms not molecularly defined
    • Specific hypothalamic nuclei mediating the phenotype not isolated
  4. 2020 High

    Two independent studies established that NPY1R expression is controlled epigenetically: the lncRNA MCM3AP-AS1 recruits DNMTs to methylate the NPY1R promoter in prostate cancer, and NPY1R enhances GABAergic currents in prefrontal cortex neurons, broadening NPY1R's known regulatory mechanisms.

    Evidence RIP, RNA pull-down, ChIP, MSP in prostate cancer cells (MCM3AP-AS1 study); electrophysiology with NPY1R antagonist in maternally deprived mice (prefrontal cortex study)

    PMID:32193153 PMID:32492699

    Open questions at the time
    • Whether epigenetic silencing of NPY1R is reversible in vivo not tested
    • Identity of the ion channel downstream of NPY1R mediating GABAergic enhancement unknown
  5. 2022 Medium

    Pharmacological blockade showed NPY1R mediates NPY's inhibition of estradiol-stimulated ER+ breast cancer growth, extending NPY1R's tumor-relevant roles beyond epigenetic silencing to growth-suppressive signaling.

    Evidence BIBP-3226 antagonist reversal of NPY growth inhibition in ER+ breast cancer cells and xenografts

    PMID:35121782

    Open questions at the time
    • Downstream signaling pathway linking NPY1R to estradiol-stimulated growth inhibition not identified
    • Single lab, not replicated independently
  6. 2023 High

    Identification of three NPY1R+ spinal interneuron subtypes and selective demonstration that Grp/Npy1r interneurons mediate Y1-agonist analgesia in neuropathic pain resolved which dorsal horn population underlies NPY1R-dependent pain gating.

    Evidence FISH subpopulation mapping, DREADDs chemogenetic inhibition, conditional Npy1r deletion from CCK-INs and NPFF-INs, intrathecal Y1 agonist in nerve injury models

    PMID:37824208

    Open questions at the time
    • Circuit connectivity of Grp/Npy1r interneurons to ascending pain pathways not mapped
    • Mechanism of Y1R signaling within these interneurons not delineated
  7. 2024 Medium

    Proximity ligation assays revealed that NPY1R forms heteroreceptor complexes with both GALR2 and TrkB in the hippocampal dentate gyrus, providing a structural basis for NPY1R's roles in neurogenesis and memory consolidation.

    Evidence In situ PLA for NPY1R-GALR2 and NPY1R-TrkB complexes, ICV agonist co-administration, PCNA/DCX neurogenesis markers, object-in-place memory tasks in rats

    PMID:38425430 PMID:38667284

    Open questions at the time
    • PLA shows proximity but not direct binding; biochemical validation of heterodimers lacking
    • Stoichiometry and structural basis of heteroreceptor complexes unknown
    • Findings from single lab, not independently replicated
  8. 2024 Medium

    Tyrosine kinase-mediated phosphorylation of NPY1R was linked to VSMC phenotypic switching and M1 macrophage polarization in intracranial aneurysm, expanding NPY1R's post-translational regulation repertoire.

    Evidence Co-IP for TK-NPY1R interaction, NPY1R overexpression, macrophage ablation rescue in mouse intracranial aneurysm model

    PMID:39353356

    Open questions at the time
    • Specific tyrosine residue(s) phosphorylated not identified
    • Single Co-IP without reciprocal validation
    • Mechanism linking phosphorylation to M1 polarization not defined
  9. 2025 High

    Multiple 2025 studies collectively established NPY1R as a cAMP-suppressive brake in adipocytes and intestinal epithelium, a marker of colon cancer-originating stem cells, and a synergistic partner with opioid receptors in spinal pain circuits, greatly expanding its peripheral and translational relevance.

    Evidence NPY treatment of primary human adipocytes with cAMP readout [PMID:41412283]; UHRF1 ChIP on NPY1R promoter with conditional KO and barrier assays [PMID:41657307]; NPY1R-CreERT2 lineage tracing with Wnt/Kras/p53 oncogenic activation [PMID:40897804]; conditional Oprm1 KO in NPY1R+ neurons with patch clamp and DREADDs [PMID:41738433]

    PMID:40897804 PMID:41412283 PMID:41657307 PMID:41738433

    Open questions at the time
    • Gi-coupling specificity versus Gq or beta-arrestin bias in adipocytes not resolved
    • Whether NPY1R+ stem cell identity reflects a functional receptor role or is merely a marker for colon cancer origin unclear
    • Molecular mechanism of NPY1R-MOR synergy at signal transduction level not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of NPY1R heteroreceptor complexes, the specific Gi-downstream effectors in each cell type, whether NPY1R post-translational modifications (phosphorylation sites, desensitization) differ across tissues, and whether NPY1R functional roles in colon cancer stem cells are receptor-activity-dependent or marker-only.
  • No crystal/cryo-EM structure of NPY1R or its heterocomplexes available
  • Tissue-specific signaling bias (Gi vs arrestin vs other effectors) not systematically compared
  • Functional necessity of NPY1R catalytic activity in LGR5+ colon cancer initiation not tested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 7
Localization
GO:0005886 plasma membrane 5 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 7 R-HSA-112316 Neuronal System 4 R-HSA-1643685 Disease 3 R-HSA-4839726 Chromatin organization 2
Partners
DNMT1GALR2NPYNTRK2OPRM1PYYUHRF1
Complex memberships
NPY1R-GALR2 heteroreceptor complexNPY1R-TrkB heteroreceptor complex

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 Chronic intracerebroventricular NPY infusion induces hyperphagia and obesity in mice lacking either Npy1r or Npy5r, demonstrating biological redundancy between Y1 and Y5 receptor signaling in NPY-mediated control of food intake. Chronic ICV NPY infusion in Npy1r and Npy5r knockout mice with measurement of food intake, fat pad weight, and plasma hormones Endocrinology High 14525913
2020 Maternal deprivation increases Npy1r expression in medial prefrontal cortex neurons; pharmacological blockade of NPY1R signaling during electrophysiological recordings demonstrated that NPY1R enhances GABAergic currents in care-deprived mice, linking NPY1R to inhibitory synaptic control of prefrontal circuits. RNAseq for gene expression, electrophysiological recordings with NPY1R antagonist in maternally deprived mice Neuropsychopharmacology High 32492699
2020 Conditional inactivation of Npy1r in forebrain excitatory neurons (limbic system) causes sex-dependent metabolic and behavioral phenotypes: male knockout mice show HPA axis hyperactivation, anxiety, reduced body weight, and reduced WAT mass, while female knockouts show increased WAT and compensatory reduction of AgRP in the arcuate nucleus, indicating estrogen-dependent resilience mechanisms. Conditional knockout mice (Npy1rrfb), behavioral testing, HPA axis measurements, WAT weighing, immunohistochemistry for AgRP Hormones and behavior High 32755609
2018 Conditional inactivation of Npy1r in Y5R-containing neurons causes impaired behavioral flexibility (reversal learning), decreased serotonergic fibers in orbitofrontal cortex (OFC), and increased baseline OFC pyramidal neuron activity; escitalopram treatment normalized OFC activity and restored behavioral flexibility, placing NPY1R-Y5R co-expression upstream of OFC serotonergic tone regulation. Conditional knockout (Npy1rY5R-/- mice), Morris water maze and water T-maze reversal tasks, c-Fos immunohistochemistry, 5-HT fiber quantification, escitalopram pharmacological rescue Neuropharmacology High 29353053
2023 Spinal dorsal horn NPY1R-expressing interneurons (Y1-INs) are necessary for neuropathic hypersensitivity after peripheral nerve injury; Y1-INs segregate into three subpopulations (Grp/Npy1r, Npff/Npy1r, Cck/Npy1r), and specifically Grp/Npy1r interneurons mediate neuropathic pain analgesia by intrathecal Y1 agonist [Leu31,Pro34]-NPY. Fluorescence in situ hybridization (FISH) for subpopulation characterization, chemogenetic inhibition (DREADDs), conditional Npy1r deletion from CCK-INs and NPFF-INs, intrathecal Y1 agonist administration in peripheral nerve injury models JCI insight High 37824208
2020 MCM3AP-AS1 lncRNA recruits DNMT1/DNMT3A/DNMT3B to the NPY1R promoter, promoting its methylation and transcriptional silencing, thereby activating the MAPK pathway to promote prostate cancer cell proliferation, invasion, and migration. RNA immunoprecipitation, RNA pull-down, chromatin immunoprecipitation (ChIP), methylation-specific PCR, lentiviral overexpression/knockdown, xenograft tumor model Molecular therapy. Nucleic acids High 32193153
2022 NPY1R mediates the inhibitory action of NPY on estradiol-stimulated growth of ER-positive breast cancer cells; NPY treatment reduced estradiol-stimulated cell growth, an effect reversed by NPY1R antagonist BIBP-3226. Pharmacological antagonism with BIBP-3226, NPY treatment of ER+ BC cells, xenograft models, proteogenomics Scientific reports Medium 35121782
2025 Pancreas-specific and whole-body knockout of Npy1r significantly decreases liver metastasis in a genetically engineered mouse model of pancreatic cancer (KPR172HC); NPY1R antagonist BIBO3304 reduces migratory capacity on cell-derived matrices and decreases liver metastasis in an intrasplenic metastasis model. Conditional and whole-body Npy1r knockout in autochthonous KPR172HC mouse model, pharmacological inhibition with BIBO3304, intrasplenic metastasis model, migration assays Science advances High 40073121
2025 NPY dose-dependently attenuates lipolysis and cAMP signaling in primary human subcutaneous adipocytes via NPY1R; adipocyte NPY1R expression is reduced after weight loss and correlates positively with body fat percentage, acting as a cell-autonomous brake on lipolysis. Single nuclei RNA sequencing of human subcutaneous WAT pre/post lifestyle intervention, pharmacological NPY treatment in primary human adipocytes, meta-analysis of 23 clinical studies, cAMP signaling measurement Molecular metabolism High 41412283
2024 NPY1R forms heteroreceptor complexes with TrkB in the hippocampal dentate gyrus; co-administration of NPY1R agonist and ketamine enhanced NPY1R-TrkB complex formation (detected by proximity ligation assay), increased BDNF expression, and promoted neuroblast proliferation and memory consolidation. In situ proximity ligation assay, immunohistochemistry for PCNA and DCX, intracerebroventricular administration, object-in-place memory task Cells Medium 38667284
2024 NPY1R forms heteroreceptor complexes with GALR2 in the dentate gyrus of the dorsal hippocampus; co-activation of NPY1R and GALR2 with agonists increases neuroblast proliferation and enhances memory consolidation in rats. In situ proximity ligation assay for NPY1R-GALR2 co-localization, intracerebroventricular injections of agonists, PCNA and DCX neurogenesis markers, object-in-place memory task Frontiers in cellular neuroscience Medium 38425430
2025 UHRF1 binds to the NPY1R promoter and promotes its methylation, leading to NPY1R transcriptional suppression; UHRF1 deficiency causes NPY1R upregulation, which attenuates cAMP/PKA/CREB signaling in intestinal epithelial cells, thereby enhancing NF-κB activation and proinflammatory responses that compromise intestinal epithelial barrier integrity. ChIP for UHRF1 binding to NPY1R promoter, Uhrf1 conditional KO mouse model, human IBD cell models, cAMP/PKA/CREB and NF-κB signaling measurements, barrier integrity assays JCI insight High 41657307
2024 TK (tyrosine kinase)-mediated phosphorylation of NPY1R protein modulates its activity; TKI treatment decreases IA formation and suppresses the contractile-to-synthetic phenotype transition of VSMCs, inflammatory response and M1 macrophage polarization in intracranial aneurysm mice; NPY1R overexpression promotes M1 macrophage polarization and VSMC phenotypic switching; macrophage ablation abolished NPY1R overexpression-mediated IA progression. Co-immunoprecipitation (Co-IP) for TK-NPY1R interaction, western blot, RT-qPCR, flow cytometry, ELISA, macrophage ablation in mouse IA model Neuropeptides Medium 39353356
2026 In the spinal dorsal horn, MOR signaling in NPY1R+ neurons is required for morphine analgesia under inflammatory pain conditions; NPY synergistically enhances morphine analgesia through NPY1R, as shown by abolition of the effect with NPY1R antagonism or Npy1r knockout; NPY1R+ interneuron hyperexcitability from inflammation is suppressed by morphine via increased rheobase, hyperpolarized resting membrane potential, and reduced action potential firing. Chemogenetics (DREADDs), conditional Oprm1 knockout in NPY1R+ neurons (AAV-Npy1r-Cre-EGFP), intrathecal NPY + antagonist, Npy1r-/- mice, in situ hybridization, whole-cell patch clamp recordings from spinal cord slices Brain : a journal of neurology High 41738433
2025 NPY1R is expressed on a subset of colorectal stem cells predominantly in the middle and distal colorectum (LGR5+ cells); selective dysregulation of Wnt signaling in NPY1R+ stem cells using CreERT2 drives colon cancer initiation predominantly in the rectum, establishing NPY1R+ cells as a source of colon cancer. NPY1R-CreERT2 mouse lines, conditional Wnt signaling activation in NPY1R+ cells, combination with oncogenic Kras and Trp53 loss, histopathology Nature cell biology High 40897804
2025 Transient intracerebroventricular siRNA knockdown of NPY1R disrupts NPY1R-GALR2 and NPY1R-TrkB heteroreceptor complexes in the ventral hippocampus without affecting hippocampal neurogenesis or depressive-like behavior, indicating compensatory mechanisms that preserve hippocampal plasticity when NPY1R is transiently reduced. ICV siRNA knockdown, in situ proximity ligation assay, PCNA immunolabeling, BDNF immunohistochemistry, forced swim test Journal of psychopharmacology Medium 41307298
2025 In the ventral hippocampus CA1 region, NPY1R-expressing neurons and NPY2R-expressing neurons form two physically non-overlapping sub-ensembles; NPY released from GABAergic interneurons acts on NPY1R+ sub-ensembles to gate early fast stages of fear memory extinction, as demonstrated by CRISPR/Cas9-mediated NPY1R knockout. Activity-dependent single-cell transcriptomics, genetically encoded calcium and NPY sensors, CRISPR/Cas9 NPY1R knockout, bidirectional chemogenetic manipulation, cued fear memory and extinction behavioral paradigm bioRxivpreprint Medium
2025 In colonic L-cells (enteroendocrine cells), PYY acts on neighboring enterochromaffin cells via NPY1R to enhance serotonin release, contributing to increased gut pain sensitivity in females; this pathway is driven by ERα-mediated upregulation of Olfr78 on L-cells, increasing PYY release in response to acetate. Estrogen receptor signaling analysis, functional gut epithelial circuit dissection in mouse colon, PYY-NPY1R-EC cell paracrine signaling assays bioRxivpreprint Medium

Source papers

Stage 0 corpus · 38 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R. BMC medical genetics 63 15090072
1984 Nitrosamine carcinogenesis in 5120 rodents: chronic administration of sixteen different concentrations of NDEA, NDMA, NPYR and NPIP in the water of 4440 inbred rats, with parallel studies on NDEA alone of the effect of age of starting (3, 6 or 20 weeks) and of species (rats, mice or hamsters). IARC scientific publications 54 6533057
2003 Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Endocrinology 38 14525913
2020 MCM3AP-AS1 KD Inhibits Proliferation, Invasion, and Migration of PCa Cells via DNMT1/DNMT3 (A/B) Methylation-Mediated Upregulation of NPY1R. Molecular therapy. Nucleic acids 24 32193153
2022 NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer. Scientific reports 21 35121782
1997 A cyclic N7,C-8 guanine adduct of N-nitrosopyrrolidine (NPYR): formation in nucleic acids and excretion in the urine of NPYR-treated rats. Chemical research in toxicology 20 9250411
2020 Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 16 32492699
2023 Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp. JCI insight 15 37824208
2020 Development and characterisation of a peptidergic N-and C-terminally stabilised mammalian NPY1R agonist which protects against diabetes induction. Biochimica et biophysica acta. General subjects 11 32007578
2020 Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions. Hormones and behavior 11 32755609
2022 Integrative Analysis of Exosomal miR-452 and miR-4713 Downregulating NPY1R for the Prevention of Childhood Obesity. Disease markers 10 35401881
2018 Conditional inactivation of Npy1r gene in mice induces behavioural inflexibility and orbitofrontal cortex hyperactivity that are reversed by escitalopram. Neuropharmacology 9 29353053
2024 Neuropeptide Y receptor 1 and galanin receptor 2 (NPY1R-GALR2) interactions in the dentate gyrus and their relevance for neurogenesis and cognition. Frontiers in cellular neuroscience 6 38425430
2024 Enhancing Cognitive Functions and Neuronal Growth through NPY1R Agonist and Ketamine Co-Administration: Evidence for NPY1R-TrkB Heteroreceptor Complexes in Rats. Cells 6 38667284
2025 Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis. Science advances 5 40073121
2024 Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions. Behavioral and brain functions : BBF 5 38549164
2024 Long-term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co-administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 5 38572811
2024 Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder. Expert opinion on therapeutic targets 5 38622072
2021 Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R. Hormones (Athens, Greece) 5 33782920
2009 Three common variants of LEP, NPY1R and GPR54 show no association with age at menarche. Hormone research 5 19506390
2024 Potentiation of antidepressant effects: NPY1R agonist and ketamine synergy enhances TrkB signaling and neurogenesis in the ventral hippocampus. Expert opinion on therapeutic targets 4 38626283
2025 NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo. Nature cell biology 3 40897804
2024 NPYR modulation: Potential for the next major advance in obesity and type 2 diabetes management? Peptides 3 38825012
2025 Peripheral expression of NPY1R-based heteroreceptor complexes reflects hippocampal neuroimmune status: Novel biomarkers for early Alzheimer's disease detection. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 1 40618588
2025 In Silico Multitarget Profiling of Non-Selective Beta-Blockers Highlights Their Potential as Key Agents in Breast Cancer Adjuvant Therapy via ADRB2, ERBB2, and NPYR Receptors. Current issues in molecular biology 1 41150737
2023 Design of Novel Imidazopyrazine Derivative against Breast Cancer via Targeted NPY1R Antagonist. Anti-cancer agents in medicinal chemistry 1 37151057
2026 Sex-related differences in aggressive and emotional behavior in mice with the conditional inactivation of limbic Npy1r. Hormones and behavior 0 41579511
2026 68Ga/211At-Labeled Specific NPY1R Peptide-Based Molecular Probe for Glioma-Targeted Imaging and Alpha Therapy. Biomacromolecules 0 41607110
2026 UHRF1 deficiency exacerbates intestinal inflammation by epigenetic modulation of NPY1R gene methylation. JCI insight 0 41657307
2026 Distinct contribution of spinal neuropeptide Y and NPY1R neurons to morphine analgesia. Brain : a journal of neurology 0 41738433
2026 Effects of Npy1r limbic conditional knock-out on adipose tissue metabolism. Neuropharmacology 0 41866109
2025 LncRNA RWDD3 Facilitates Leydig Cell Steroidogenesis by Regulating the miR-1388-5p/NPY1R/cAMP Pathway in Yanshan Cashmere Goats. Animals : an open access journal from MDPI 0 40646785
2025 Skin Resident T Cell Interactions with NPY1R+ Neurons During Wound Repair Are Impaired by Obesity. bioRxiv : the preprint server for biology 0 40661589
2025 Nobiletin Alleviates Npy1r-Mediated Insulin Secretion Deficiency of Islet β-Cells via the Clock-Modulatory Signaling. Molecular nutrition & food research 0 40913544
2025 Transcriptome analysis of induced pluripotent stem cells' osteogenic differentiation reveals NPY1R activating PI3K/AKT/mTOR in alveolar bone loss during periodontitis. American journal of translational research 0 41268237
2025 Intracerebroventricular knockdown of NPY1R disrupts NPY1R-GALR2/TrkB heteroreceptor complexes without affecting neuroplasticity or depressive-like behaviour. Journal of psychopharmacology (Oxford, England) 0 41307298
2025 Single cell transcriptomics of human weight loss links adipocyte NPY1R to control of lipolysis. Molecular metabolism 0 41412283
2024 Phosphorylated NPY1R regulates phenotypic transition of vascular smooth muscle cells, inflammatory response and macrophage infiltration to promote intracranial aneurysm progression. Neuropeptides 0 39353356