- Length
- 510 aa
- Mass
- 55.5 kDa
- Annotated
- 2026-04-29
130 papers in source corpus
25 papers cited in narrative
25 extracted findings
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
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Mechanism profile
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Evidence
Reading pass · 25 per-paper findings extracted from the source corpus
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 2001 | Nectin-4 was identified as a new member of the nectin family that interacts with afadin (an F-actin-associated molecule) via its carboxyl-terminal cytoplasmic sequence, co-localizes with afadin at cadherin-based adherens junctions in MDCKII epithelial cells, and trans-interacts heterophilically with nectin-1 through V domain interactions. Nectin-4-Fc binds cells expressing nectin-1 but not nectin-2, nectin-3, or PVR/CD155; reciprocal pulldown and in vitro physical interaction assays confirmed the nectin-1/nectin-4 interaction. Nectin-4 also exhibits homophilic binding. | Recombinant Fc-fusion protein binding assays, co-immunoprecipitation, in vitro pulldown, co-localization by immunofluorescence in MDCKII cells | The Journal of biological chemistry | High | 11544254 |
| 1999 | The nectin family member PRR/nectin is recruited to cadherin-based adherens junctions through direct interaction of its C-terminal cytoplasmic PDZ-binding motif with the PDZ domain of afadin, an actin filament-binding protein; nectin shows Ca2+-independent cell-cell adhesion activity. | Co-immunoprecipitation, co-localization by immunofluorescence, cell aggregation assays | The Journal of cell biology | High | 10225955 |
| 2002 | The V domain of nectin-1 is the major functional region mediating trans-heterointeraction with nectin-4 (and nectin-3). Affinity measurements showed the nectin-1/nectin-4 KD is ~100 nM, weaker than nectin-1/nectin-3 (KD ~1 nM) but stronger than nectin-1 homophilic (KD ~1 µM). The minimal binding region on the nectin-1 V domain was mapped to the C-C'-C"-D β-strands using chimeric nectin-1/PVR receptors. | Surface plasmon resonance / affinity measurements, competitive binding with soluble Fc-fusions, monoclonal antibody blocking, chimeric receptor domain-swap experiments | The Journal of biological chemistry | High | 12011057 |
| 2005 | Nectin-4 ectodomain shedding is mediated by the metalloprotease TACE/ADAM-17: shedding is constitutively produced, strongly enhanced by PMA, inhibited by TAPI-1 or TIMP-3, abolished in TACE-deficient fibroblasts, and modulated by TACE overexpression or siRNA silencing. The soluble form (~43 kDa) corresponds to the entire nectin-4 ectodomain. | siRNA knockdown and overexpression of TACE, TACE-deficient fibroblasts, pharmacological inhibitors (TAPI-1, TIMP-3), Western blot of shed product, PMA stimulation | The Journal of biological chemistry | High | 15784625 |
| 2011 | Nectin-4 (PVRL4) serves as the epithelial cell receptor for measles virus. Its membrane-distal IgV domain supports virus attachment and entry; antibodies and siRNA against PVRL4 block measles virus infection. Measles virus infection downregulates PVRL4 surface expression. | Expression vector transfection of non-susceptible cell lines, siRNA knockdown, antibody blocking, virus binding assay, flow cytometry, confocal microscopy, surface biotinylation | PLoS pathogens | High | 21901103 |
| 2011 | Nectin-4 is the epithelial receptor for measles virus exit from the host: it interacts with the viral attachment protein (hemagglutinin) with high affinity through its membrane-distal IgV domain, sustains MV entry and non-cytopathic lateral spread in well-differentiated primary human airway epithelial sheets infected basolaterally, and is downregulated in infected epithelial cells including macaque tracheae. | Functional rescue transfection in non-permissive cells, primary airway epithelial cultures, basolateral infection assays, immunohistochemistry in macaque tissues, in vitro binding assays | Nature | High | 22048310 |
| 2012 | Crystal structure of the membrane-distal IgV domain of human nectin-4 in complex with measles virus hemagglutinin (MV-H) revealed that nectin-4 binds exclusively via its N-terminal IgV domain to the β4-β5 groove of MV-H, with the contact interface dominated by hydrophobic interactions. The nectin-4 binding site on MV-H overlaps extensively with those of the other two MV receptors (CD46 and SLAM). | X-ray crystallography (co-crystal structure of nectin-4 IgV domain with MV-H) | Nature structural & molecular biology | High | 23202587 |
| 2012 | Crystal structures of the full ectodomains of all four nectins and Necl-5 revealed a conserved stereotyped dimeric interface (C-C'-C"-D β-strand region of the V domain) representing the adhesive trans interaction. Quantitative binding measurements defined homophilic affinities and heterophilic specificity across the family. Targeted cross-linking confirmed the dimer interface as the adhesive trans contact. | X-ray crystallography of natively glycosylated ectodomains, surface plasmon resonance, targeted cross-linking | Nature structural & molecular biology | High | 22902367 |
| 2013 | The measles virus hemagglutinin β4-β5 hydrophobic groove governs functional interactions with nectin-4 and CD46 but not SLAM. A single substitution in this groove drastically reduced nectin-4 and CD46 binding while minimally altering SLAM binding. Soluble nectin-4 blocked vaccine MV entry via nectin-4 and CD46 but only partially reduced SLAM-mediated entry. | Site-directed mutagenesis of MV-H, cell fusion assays, soluble nectin-4 competition, surface plasmon resonance binding kinetics, recombinant virus construction | Journal of virology | High | 23760251 |
| 2013 | PVRL4 promotes anchorage-independent cell proliferation by driving cell-to-cell attachment and matrix-independent integrin β4/SHP-2/c-Src signaling activation. PVRL4 was identified via a gain-of-function screen for anchorage independence; breast cancer cell transformation was shown to be dependent on PVRL4, and blocking PVRL4-mediated cell-to-cell attachment with monoclonal antibodies inhibited orthotopic tumor growth in vivo. | Gain-of-function screen, co-immunoprecipitation of integrin β4/SHP-2/c-Src complex, siRNA knockdown, monoclonal antibody blocking, orthotopic xenograft mouse models | eLife | High | 23682311 |
| 2009 | Exogenous expression of Nectin-4 in mammalian cells increased lamellipodia formation and invasive ability through activation of the small GTPase Rac1; siRNA-mediated suppression of Nectin-4 inhibited cell growth in lung cancer cells. | siRNA knockdown, exogenous overexpression, Rac1 activation assay, invasion assay, lamellipodia quantification | Cancer research | Medium | 19679554 |
| 2014 | Nectin-4 mutations causing EDSS1 (ectodermal dysplasia-syndactyly syndrome) perturb the Rac1 pathway: trans-interaction of nectin-1 and nectin-4 induces Rac1 activation, and mutant nectin-4 (p.Val242Met, p.Thr185Met) delays cadherin recruitment at adherens junctions and impairs nectin-1 clustering at contact sites in keratinocytes, demonstrating a role for the nectin-1/nectin-4 interaction in early adherens junction formation. | Patient keratinocytes and skin biopsy, ectopic expression of mutant and WT nectin-4, cell aggregation assays, immunofluorescence for cadherin/nectin-1 clustering, Rac1 activation assay | The Journal of investigative dermatology | High | 24577405 |
| 2010 | Loss-of-function mutations in PVRL4 (encoding nectin-4) cause ectodermal dysplasia-syndactyly syndrome (EDSS). Mutant nectin-4 from patients lost the capability to bind nectin-1. In patient keratinocytes, discrete hair follicle structures showed alterations in membrane localization of nectin-afadin and cadherin-catenin complexes essential for adherens junction formation, and reorganization of the actin cytoskeleton was observed. | Homozygosity mapping, candidate gene sequencing, patient keratinocyte functional assays (nectin-1 binding by pull-down), immunofluorescence of adherens junction components and actin cytoskeleton in patient tissue | American journal of human genetics | High | 20691405 |
| 2015 | Nectin-4 expression in stratified epithelia is regulated by IRF6: depletion of IRF6 reduces Pvrl4 expression in keratinocytes. In AEC syndrome (p63 mutation), reduced IRF6 expression correlates with decreased Pvrl4 expression. By contrast, Pvrl1 (nectin-1) is a direct p63 target gene (p63 binds to two conserved intronic Pvrl1 enhancer regions by ChIP), but Pvrl4 regulation is independent of p63 and linked to IRF6-mediated epidermal differentiation. | Chromatin immunoprecipitation (ChIP), siRNA knockdown of p63 and IRF6, qRT-PCR, p63-null mouse skin, patient AEC keratinocytes, conditional AEC mouse model | Experimental dermatology | Medium | 25387952 |
| 2015 | Measles virus spread in human airway epithelial (HAE) cells requires the nectin-4/afadin complex: afadin knockdown limited infectious-center formation, and a nectin-4 mutant lacking the afadin-binding site in its cytoplasmic tail was less effective than WT nectin-4 at promoting MV infection. Spread occurred through intercellular membrane pores (cytoplasm flow between columnar cells on lateral surfaces) rather than visible syncytia. | siRNA knockdown of afadin in primary HAE cultures, nectin-4 cytoplasmic-tail mutant expression in porcine airway epithelial primary cultures, high-resolution video microscopy, GFP cytoplasm-flow assays | Journal of virology | High | 25926640 |
| 2017 | Nectin-4 ectodomain shedding in ovarian cancer is mediated by both ADAM17 and ADAM10. LPA stimulates Nectin-4 shedding; small-molecule inhibitors and siRNA knockdown of ADAM10 and ADAM17 confirmed their roles. Ascites fluid significantly increased sN4 shedding. Shed Nectin-4 is detectable at 2–20-fold higher levels in ascites than in serum. | siRNA knockdown of ADAM10 and ADAM17, small-molecule inhibitor assays, LPA stimulation, ELISA quantification of shed nectin-4 in ascites and serum from matched patient samples | The Journal of biological chemistry | High | 28232483 |
| 2018 | Matrix-detached epithelial and carcinoma cells cluster spontaneously via PVRL4 (Nectin-4), activating a PVRL4/α6β4 integrin/Src signaling axis that sustains GPX4 expression to resist ferroptosis. In the absence of α6β4, PVRL4-mediated clustering increased lipid peroxidation and triggered ferroptosis; when clustering was inhibited, single cells were more susceptible to apoptosis than ferroptosis. | siRNA knockdown of PVRL4 and α6β4, antibody blocking of clustering, lipid peroxidation assays, cell viability assays, Western blot for GPX4 | The Journal of biological chemistry | High | 29934307 |
| 2017 | Nectin-4 promotes breast cancer stem cell (BCSC) self-renewal and metastasis by activating WNT/β-catenin signaling via the PI3K/Akt axis. Nectin-4 depletion inhibited EMT, invasion, and WNT/β-catenin pathway activity; overexpression of Nectin-4 in null cells induced WNT/β-catenin signaling via PI3K/Akt. | siRNA knockdown and overexpression in breast cancer cell lines, in vitro sphere formation, invasion assay, in vivo xenograft, ex vivo and clinical sample analysis, Western blot for PI3K/Akt/β-catenin pathway components | The international journal of biochemistry & cell biology | Medium | 28600142 |
| 2018 | Under hypoxia, ADAM-17 expressed in metastatic breast cancer stem cells sheds the nectin-4 ecto-domain into the microenvironment, which then physically interacts with integrin-β4 on endothelial cells, promoting angiogenesis via the Src/PI3K/AKT/iNOS pathway (but not Phospho-Erk or NF-κB). | Co-immunoprecipitation of shed nectin-4 ecto-domain with integrin-β4, in vitro tube formation, CAM assay, in vivo angiogenesis models, pathway inhibitors, siRNA knockdown | The international journal of biochemistry & cell biology | Medium | 30056265 |
| 2019 | Nectin-4 cis-interacts with ErbB2 (and its trastuzumab-resistant splice variants p95-ErbB2 and ErbB2ΔEx16) through the third Ig-like domain of nectin-4 and domain IV of ErbB2, enhancing ErbB2 dimerization and activation and downstream PI3K/AKT signaling for DNA synthesis. Nectin-4 also enhanced p95-ErbB2-induced JAK-STAT3 signaling. | Co-immunoprecipitation, domain-mapping using truncation/deletion constructs of nectin-4 and ErbB2, Western blot for PI3K-AKT and JAK-STAT3 phosphorylation, DNA synthesis assays in T47D and SUM190-PT breast cancer cell lines | Scientific reports | Medium | 31831814 |
| 2020 | Nectin-4 is a novel ligand of the immune checkpoint receptor TIGIT. Unlike other TIGIT ligands (which also bind additional receptors), Nectin-4 interacts exclusively with TIGIT. The TIGIT-Nectin-4 interaction inhibits NK cell cytotoxicity; blocking Nectin-4 antibodies enhanced tumor cell killing in vitro and in vivo. | Fusion protein staining of NK cells, TIGIT binding assays, NK cytotoxicity killing assays, blocking antibody experiments in vitro and in syngeneic mouse models | Journal for immunotherapy of cancer | Medium | 32503945 |
| 2020 | The NECTIN4 endo-domain (lacking extracellular region) translocates to the nucleus via physical interaction with IMPORTIN-α2 and activates DNA repair, while the ecto-domain (lacking signal peptide and cytoplasmic region) is expressed in the cytoplasm and specifically activates angiogenesis. Full-length NECTIN-4 modulates both processes. | Domain-specific NECTIN-4 constructs overexpressed in 5-FU-resistant cervical cancer stem cells, co-immunoprecipitation with IMPORTIN-α2, nuclear fractionation, comet assay, γ-H2AX immunofluorescence, BER pathway assays, in vitro tube formation, CAM assay | European journal of pharmacology | Medium | 32603697 |
| 2023 | Nectin-4 plays a causative role in senescence-associated cell size enlargement via the Src family kinase (SFK)/PI3K/Rac1 pathway. Overexpression of Nectin-4 caused enlarged cell morphology resembling senescent cells; knockdown of Nectin-4 during DNA damage-induced senescence suppressed cell size increase without affecting senescence induction per se. Nectin-4 knockdown also induced apoptosis in senescent cells, and cell size was positively correlated with survival rate. | Overexpression and knockdown of Nectin-4, pharmacological inhibition of SFK/PI3K/Rac1, single-cell tracking microscopy, flow cytometry for cell size, apoptosis assays | Scientific reports | Medium | 38062106 |
| 2020 | ERRα (estrogen-related receptor-α) transcriptionally activates NECTIN-4 by directly binding to the NECTIN-4 promoter, as shown by chromatin immunoprecipitation and dual-luciferase reporter assays. ERRα-induced gallbladder cancer cell proliferation and invasion were antagonized by Nectin-4 depletion. Nectin-4 depletion inhibited ERRα-induced PI3K/AKT pathway activation. | Chromatin immunoprecipitation (ChIP), dual-luciferase reporter assay, siRNA knockdown, overexpression, Western blot for PI3K/AKT pathway components, in vivo xenograft | Cancer science | Medium | 32030850 |
| 2005 | PICK-1 (protein interacting with C-kinase-1) directly interacts with nectins in a PDZ-domain-dependent manner and co-localizes with nectins at adherens junctions in epithelial cells, suggesting a role for PICK-1 in the regulation of nectin-based cell junctions. | Co-immunoprecipitation, GST-pulldown, immunofluorescence co-localization in epithelial cells | FEBS letters | Low | 15811349 |
Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2015 | The BioPlex Network: A Systematic Exploration of the Human Interactome. | Cell | 1118 | 26186194 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 2020 | A reference map of the human binary protein interactome. | Nature | 849 | 32296183 |
| 2003 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | Nature genetics | 754 | 14702039 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2016 | Enfortumab Vedotin Antibody-Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models. | Cancer research | 552 | 27013195 |
| 2011 | Adherens junction protein nectin-4 is the epithelial receptor for measles virus. | Nature | 478 | 22048310 |
| 1999 | Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein. | The Journal of cell biology | 450 | 10225955 |
| 2011 | Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus. | PLoS pathogens | 409 | 21901103 |
| 2005 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | Genome research | 409 | 16344560 |
| 2020 | EV-101: A Phase I Study of Single-Agent Enfortumab Vedotin in Patients With Nectin-4-Positive Solid Tumors, Including Metastatic Urothelial Carcinoma. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | 278 | 32031899 |
| 2001 | Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. | The Journal of biological chemistry | 272 | 11544254 |
| 2012 | Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells. | Cell death and differentiation | 262 | 23154388 |
| 2021 | Enfortumab vedotin after PD-1 or PD-L1 inhibitors in cisplatin-ineligible patients with advanced urothelial carcinoma (EV‑201): a multicentre, single-arm, phase 2 trial. | The Lancet. Oncology | 230 | 33991512 |
| 2009 | Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. | Cancer research | 225 | 19679554 |
| 2023 | Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance. | Clinical cancer research : an official journal of the American Association for Cancer Research | 176 | 36534531 |
| 2014 | E-cadherin interactome complexity and robustness resolved by quantitative proteomics. | Science signaling | 162 | 25468996 |
| 2010 | Nectin 4 overexpression in ovarian cancer tissues and serum: potential role as a serum biomarker. | American journal of clinical pathology | 162 | 20959669 |
| 1998 | The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule. | Blood | 151 | 9845526 |
| 2007 | Nectin-4 is a new histological and serological tumor associated marker for breast cancer. | BMC cancer | 149 | 17474988 |
| 2021 | Heterogeneity in NECTIN4 Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin. | Clinical cancer research : an official journal of the American Association for Cancer Research | 141 | 34108177 |
| 2013 | In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. | Proteomics | 138 | 23533145 |
| 2015 | Nectin-4 expression contributes to tumor proliferation, angiogenesis and patient prognosis in human pancreatic cancer. | Journal of experimental & clinical cancer research : CR | 137 | 25888293 |
| 2005 | Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. | The Journal of biological chemistry | 133 | 15784625 |
| 2021 | Expression of Nectin-4 in Bladder Urothelial Carcinoma, in Morphologic Variants, and Nonurothelial Histotypes. | Applied immunohistochemistry & molecular morphology : AIMM | 131 | 33901032 |
| 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. | Journal of proteomics | 126 | 23376485 |
| 2017 | Nectin-4: a new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer. | Annals of oncology : official journal of the European Society for Medical Oncology | 124 | 27998973 |
| 2002 | Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain. | The Journal of biological chemistry | 118 | 12011057 |
| 2012 | Nectin ectodomain structures reveal a canonical adhesive interface. | Nature structural & molecular biology | 109 | 22902367 |
| 2022 | Management of Dermatologic Events Associated With the Nectin-4-directed Antibody-Drug Conjugate Enfortumab Vedotin. | The oncologist | 108 | 35274723 |
| 2020 | Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity. | Journal for immunotherapy of cancer | 104 | 32503945 |
| 2013 | A role for PVRL4-driven cell-cell interactions in tumorigenesis. | eLife | 104 | 23682311 |
| 2024 | NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | 101 | 38657187 |
| 2012 | Nectin 4 is the epithelial cell receptor for measles virus. | Trends in microbiology | 100 | 22721863 |
| 2010 | Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome. | American journal of human genetics | 97 | 20691405 |
| 2016 | A novel PI3K/AKT signaling axis mediates Nectin-4-induced gallbladder cancer cell proliferation, metastasis and tumor growth. | Cancer letters | 92 | 26949052 |
| 2012 | Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4. | Nature structural & molecular biology | 90 | 23202587 |
| 2017 | Nectin-4 is a breast cancer stem cell marker that induces WNT/β-catenin signaling via Pi3k/Akt axis. | The international journal of biochemistry & cell biology | 82 | 28600142 |
| 2023 | First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma. | Clinical cancer research : an official journal of the American Association for Cancer Research | 76 | 37093191 |
| 2020 | Expression of Nectin-4 and PD-L1 in Upper Tract Urothelial Carcinoma. | International journal of molecular sciences | 76 | 32751328 |
| 2021 | Nectin cell adhesion molecule-4 (NECTIN-4): A potential target for cancer therapy. | European journal of pharmacology | 72 | 34547246 |
| 2013 | Characterization of ovine Nectin-4, a novel peste des petits ruminants virus receptor. | Journal of virology | 70 | 23388720 |
| 2017 | Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17. | The Journal of biological chemistry | 64 | 28232483 |
| 2022 | The Anti-Nectin 4: A Promising Tumor Cells Target. A Systematic Review. | Molecular cancer therapeutics | 62 | 35131876 |
| 2021 | Role of Nectin‑4 protein in cancer (Review). | International journal of oncology | 58 | 34664682 |
| 2022 | BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors. | Molecular cancer therapeutics | 57 | 36112771 |
| 2011 | The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma. | Folia histochemica et cytobiologica | 57 | 21526486 |
| 2022 | Overcoming Resistance to Anti-Nectin-4 Antibody-Drug Conjugate. | Molecular cancer therapeutics | 55 | 35534238 |
| 2022 | Nectin-4-targeted immunoSPECT/CT imaging and photothermal therapy of triple-negative breast cancer. | Journal of nanobiotechnology | 55 | 35614462 |
| 2018 | Cell clustering mediated by the adhesion protein PVRL4 is necessary for α6β4 integrin-promoted ferroptosis resistance in matrix-detached cells. | The Journal of biological chemistry | 54 | 29934307 |
| 2011 | A secreted protein microarray platform for extracellular protein interaction discovery. | Analytical biochemistry | 53 | 21982860 |
| 2017 | Nectin-4 promotes gastric cancer progression via the PI3K/AKT signaling pathway. | Human pathology | 52 | 29208564 |
| 2014 | The tumor-associated marker, PVRL4 (nectin-4), is the epithelial receptor for morbilliviruses. | Viruses | 51 | 24892636 |
| 2018 | The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4. | The international journal of biochemistry & cell biology | 50 | 30056265 |
| 2017 | The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate. | Oncotarget | 50 | 28038455 |
| 2015 | The Nectin-4/Afadin Protein Complex and Intercellular Membrane Pores Contribute to Rapid Spread of Measles Virus in Primary Human Airway Epithelia. | Journal of virology | 50 | 25926640 |
| 2015 | Characterization of human reflex tear proteome reveals high expression of lacrimal proline-rich protein 4 (PRR4). | Proteomics | 48 | 26173177 |
| 2014 | Membranous Nectin-4 expression is a risk factor for distant relapse of T1-T2, N0 luminal-A early breast cancer. | Oncogenesis | 48 | 25178039 |
| 2020 | RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. | Proceedings of the National Academy of Sciences of the United States of America | 47 | 32513696 |
| 2022 | Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors. | Frontiers in immunology | 46 | 36479116 |
| 2019 | Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse. | Journal of cancer research and clinical oncology | 45 | 31617074 |
| 2023 | Assessment of PD-L1, TROP2, and nectin-4 expression in penile squamous cell carcinoma. | Human pathology | 42 | 37977513 |
| 2019 | Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity. | Autophagy | 42 | 31318632 |
| 2021 | Nectin-4 promotes lymphangiogenesis and lymphatic metastasis in breast cancer by regulating CXCR4-LYVE-1 axis. | Vascular pharmacology | 39 | 33945869 |
| 2020 | PARP inhibitor Veliparib (ABT-888) enhances the anti-angiogenic potentiality of Curcumin through deregulation of NECTIN-4 in oral cancer: Role of nitric oxide (NO). | Cellular signalling | 39 | 33373686 |
| 2019 | Nanoquinacrine sensitizes 5-FU-resistant cervical cancer stem-like cells by down-regulating Nectin-4 via ADAM-17 mediated NOTCH deregulation. | Cellular oncology (Dordrecht, Netherlands) | 37 | 30603978 |
| 2013 | The measles virus hemagglutinin β-propeller head β4-β5 hydrophobic groove governs functional interactions with nectin-4 and CD46 but not those with the signaling lymphocytic activation molecule. | Journal of virology | 37 | 23760251 |
| 2024 | Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts. | Histopathology | 36 | 38196202 |
| 2020 | NECTIN4 Expression in Extramammary Paget's Disease: Implication of a New Therapeutic Target. | International journal of molecular sciences | 36 | 32824340 |
| 2016 | Expression and clinical significance of Nectin-4 in hepatocellular carcinoma. | OncoTargets and therapy | 36 | 26793002 |
| 2015 | SLAM- and nectin-4-independent noncytolytic spread of canine distemper virus in astrocytes. | Journal of virology | 35 | 25787275 |
| 2019 | NECTIN4 promotes papillary thyroid cancer cell proliferation, migration, and invasion and triggers EMT by activating AKT. | Cancer management and research | 34 | 31114323 |
| 2019 | Nectin-4 cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, enhancing their activation and DNA synthesis. | Scientific reports | 34 | 31831814 |
| 2016 | Preclinical Evaluation of an Anti-Nectin-4 ImmunoPET Reagent in Tumor-Bearing Mice and Biodistribution Studies in Cynomolgus Monkeys. | Molecular imaging and biology | 34 | 27122234 |
| 2005 | PICK-1: a scaffold protein that interacts with Nectins and JAMs at cell junctions. | FEBS letters | 34 | 15811349 |
| 2022 | Nectin-4: a Novel Therapeutic Target for Skin Cancers. | Current treatment options in oncology | 33 | 35312963 |
| 2014 | Nectin-4 mutations causing ectodermal dysplasia with syndactyly perturb the rac1 pathway and the kinetics of adherens junction formation. | The Journal of investigative dermatology | 33 | 24577405 |
| 2023 | An Analysis of Nectin-4 (PVRL4) in Penile Squamous Cell Carcinoma. | European urology open science | 31 | 36660545 |
| 2021 | NECTIN4: A Novel Therapeutic Target for Melanoma. | International journal of molecular sciences | 31 | 33478111 |
| 2021 | Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target? | Biomedicines | 31 | 33808400 |
| 2015 | p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis. | Experimental dermatology | 31 | 25387952 |
| 2012 | Canine distemper virus with the intact C protein has the potential to replicate in human epithelial cells by using human nectin4 as a receptor. | Virology | 31 | 23174504 |
| 2023 | Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for Treatment of Nectin-4-expressing Cancers. | Molecular cancer therapeutics | 30 | 37196158 |
| 2017 | Measles Virus Enters Breast and Colon Cancer Cell Lines through a PVRL4-Mediated Macropinocytosis Pathway. | Journal of virology | 29 | 28250131 |
| 2024 | Therapeutic prospects of nectin-4 in cancer: applications and value. | Frontiers in oncology | 27 | 38606099 |
| 2022 | Nectin-4 is widely expressed in head and neck squamous cell carcinoma. | Oncotarget | 27 | 36268557 |
| 2020 | Estrogen-related receptor-α promotes gallbladder cancer development by enhancing the transcription of Nectin-4. | Cancer science | 27 | 32030850 |
| 2014 | The V domain of dog PVRL4 (nectin-4) mediates canine distemper virus entry and virus cell-to-cell spread. | Virology | 27 | 24725937 |
| 2014 | Characterization of lacrimal proline-rich protein 4 (PRR4) in human tear proteome. | Proteomics | 27 | 24782455 |
| 2024 | Nectin-4-directed antibody-drug conjugates (ADCs): Spotlight on preclinical and clinical evidence. | Life sciences | 26 | 39002610 |
| 2020 | Recombinant SLAMblind Measles Virus Is a Promising Candidate for Nectin-4-Positive Triple Negative Breast Cancer Therapy. | Molecular therapy oncolytics | 26 | 33145396 |
| 2014 | Use of SLAM and PVRL4 and identification of pro-HB-EGF as cell entry receptors for wild type phocine distemper virus. | PloS one | 26 | 25171206 |
| 2020 | Nanoformulated quinacrine regulates NECTIN-4 domain specific functions in cervical cancer stem cells. | European journal of pharmacology | 25 | 32603697 |
| 2019 | Enfortumab Vedotin, a fully human monoclonal antibody against Nectin 4 conjugated to monomethyl auristatin E for metastatic urothelial Carcinoma. | Expert opinion on investigational drugs | 25 | 31526130 |
| 2011 | Mutation in PVRL4 gene encoding nectin-4 underlies ectodermal-dysplasia-syndactyly syndrome (EDSS1). | Journal of human genetics | 25 | 21346770 |
| 2020 | Inhibition of Ovarian Cancer Cell Spheroid Formation by Synthetic Peptides Derived from Nectin-4. | International journal of molecular sciences | 24 | 32629816 |
| 2024 | Translational PET Imaging of Nectin-4 Expression in Multiple Different Cancers with 68Ga-N188. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | 22 | 38719240 |
| 2020 | Enfortumab Vedotin-ejfv: A First-in-Class Anti-Nectin-4 Antibody-Drug Conjugate for the Management of Urothelial Carcinoma. | The Annals of pharmacotherapy | 22 | 32945172 |
| 2019 | Serum nectin-2 and nectin-4 are diagnostic in lung cancer: which is superior? | Wiener klinische Wochenschrift | 21 | 31440821 |
| 2025 | Spatial Expression of HER2, NECTIN4, and TROP-2 in Muscle-Invasive Bladder Cancer and Metastases: Implications for Pathological and Clinical Management. | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc | 18 | 40086591 |
| 2024 | Near-infrared photoimmunotherapy targeting Nectin-4 in a preclinical model of bladder cancer. | Cancer letters | 18 | 38272345 |
| 2024 | A potential strategy for bladder cancer treatment: inhibiting autophagy to enhance antitumor effects of Nectin-4-MMAE. | Cell death & disease | 18 | 38664366 |
| 2024 | A humanized trivalent Nectin-4-targeting nanobody drug conjugate displays potent antitumor activity in gastric cancer. | Journal of nanobiotechnology | 18 | 38755613 |
| 2022 | Nectin-4 promotes osteosarcoma progression and metastasis through activating PI3K/AKT/NF-κB signaling by down-regulation of miR-520c-3p. | Cancer cell international | 18 | 35953862 |
| 2019 | Functional characterization of seven-band grouper immunoglobulin like cell adhesion molecule, Nectin4 as a cellular receptor for nervous necrosis virus. | Fish & shellfish immunology | 17 | 31404634 |
| 2014 | The diagnostic efficacy of nectin 4 expression in ovarian cancer patients. | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals | 17 | 25019423 |
| 2023 | Scratching the Surface: NECTIN-4 as a Surrogate for Enfortumab Vedotin Resistance. | Clinical cancer research : an official journal of the American Association for Cancer Research | 16 | 36749325 |
| 2023 | An iodine‑labelled Antibody-drug conjugate PET probe for noninvasive monitoring of Nectin-4 expression in urothelial carcinoma. | International journal of pharmaceutics | 16 | 38160990 |
| 2018 | Potential role for nectin-4 in the pathogenesis of pre-eclampsia: a molecular genetic study. | BMC medical genetics | 16 | 30217189 |
| 2024 | Biomarkers of Response to Anti-NECTIN4 Antibody-Drug Conjugate Enfortumab Vedotin in Urothelial Cancer. | European urology focus | 15 | 38631991 |
| 2022 | CircRNA PRH1-PRR4 stimulates RAB3D to regulate the malignant progression of NSCLC by sponging miR-877-5p. | Thoracic cancer | 15 | 35076987 |
| 2014 | A novel homozygous nonsense mutation in the PVRL4 gene and expansion of clinical spectrum of EDSS1. | Annals of human genetics | 15 | 25529316 |
| 2025 | Pilot Study of Nectin-4-Targeted PET Imaging Agent 68Ga-FZ-NR-1 in Triple-Negative Breast Cancer from Bench to First-in-Human. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | 14 | 39947908 |
| 2022 | TROP-2, Nectin-4, GPNMB, and B7-H3 Are Potentially Therapeutic Targets for Anaplastic Thyroid Carcinoma. | Cancers | 14 | 35158847 |
| 2025 | Bulumtatug Fuvedotin (BFv, 9MW2821), a next-generation Nectin-4 targeting antibody-drug conjugate, in patients with advanced solid tumors: a first-in-human, open-label, multicenter, phase I/II study. | Annals of oncology : official journal of the European Society for Medical Oncology | 13 | 40288679 |
| 2022 | Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology. | Journal of medicinal chemistry | 13 | 35819182 |
| 2019 | Nectin-4 and p63 immunohistochemical expression in canine prostate tumourigenesis. | Veterinary and comparative oncology | 13 | 30767361 |
| 2016 | Identification of a naturally processed HLA-A*02:01-restricted CTL epitope from the human tumor-associated antigen Nectin-4. | Cancer immunology, immunotherapy : CII | 13 | 27514672 |
| 2024 | Nectin-4 Positivity in Genitourinary Malignancies: A Systematic Review. | JCO precision oncology | 12 | 39626158 |
| 2021 | Expressions of PD-L1 and Nectin-4 in urothelial cancer patients treated with pembrolizumab. | Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico | 12 | 34687441 |
| 2025 | Nectin-4 expression patterns and therapeutics in oncology. | Cancer letters | 11 | 40209851 |
| 2024 | TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma. | Pathologica | 11 | 38482675 |
| 2022 | Heterogenous NECTIN4 expression in urothelial high-risk non-muscle-invasive bladder cancer. | Virchows Archiv : an international journal of pathology | 11 | 35484425 |
| 2024 | Effects of PEGylation on Imaging Contrast of 68Ga-Labeled Bicyclic Peptide PET Probes Targeting Nectin-4. | Molecular pharmaceutics | 10 | 39069891 |
| 2024 | Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects. | Breast (Edinburgh, Scotland) | 10 | 39577073 |
| 2023 | Nectin-4: a Tumor Cell Target and Status of Inhibitor Development. | Current oncology reports | 10 | 36696077 |
| 2023 | Nectin-4 has emerged as a compelling target for breast cancer. | European journal of pharmacology | 10 | 38059449 |
| 2023 | Nectin-4 regulates cellular senescence-associated enlargement of cell size. | Scientific reports | 9 | 38062106 |