Affinage

NCOA6

Nuclear receptor coactivator 6 · UniProt Q14686

Length
2063 aa
Mass
219.1 kDa
Annotated
2026-06-10
100 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NCOA6 (RAP250/NRC/AIB3) is a large nuclear scaffold coactivator that bridges ligand-activated nuclear receptors and other transcription factors to chromatin-modifying machinery, functioning as an essential, non-redundant pro-survival coregulator in development and tissue homeostasis (PMID:12556486, PMID:12368298, PMID:15143190). It contacts nuclear receptors through multiple LXXLL (nuclear receptor box) motifs in a ligand-dependent manner and drives transcription via a glutamine-rich N-terminal activation domain, with distinct activation domains (AD1/AD2) and dimerization mediated by a region overlapping LXXLL-1 (PMID:10681503, PMID:17536006). The individual LXXLL motifs are functionally specialized in vivo: the C-terminal LXXLL-2 is selectively required for LXRα-driven hepatic lipogenesis and cholesterol/bile acid homeostasis while dispensable for ERα in mammary gland, and the same motif mediates direct binding to the Smad2/3 MH2 domain to coactivate TGF-β signaling (PMID:17908797, PMID:18263591). Beyond classical receptors, NCOA6 coactivates STAT-2 and p53, the latter indirectly through a Trap80–NIF-1–NCOA6 axis, and partners with the cotransducer NIF-1, which couples NCOA6 to CCR4-NOT (CNOT6/CNOT9) components (PMID:12215545, PMID:17536006, PMID:18180299). Mechanistically, NCOA6 nucleates H3K4 methyltransferase activity: it is a subunit of the Drosophila Trr (MLL-family) complex and a direct partner of the Hippo coactivator Yorkie required for H3K4 methylation at target loci (PMID:25027438). At mammalian enhancers it constitutively maintains enhancer-promoter chromatin looping and, upon estradiol stimulation, recruits ERα, p300, MLL4, and RNA Pol II to deposit activating histone marks (H3K4me1/3, H3K9ac, H3K27ac) and drive target gene transcription (PMID:31744881). NCOA6 also bridges combinatorial transcription-factor inputs, mediating PXR/HNF4α synergy at CYP2C9 and SREBP-1c-dependent Nampt induction in β-cells (PMID:21292004, PMID:28435063). Genetic loss is embryonic lethal with placental and cardiac failure, and tissue-specific perturbation causes dilated cardiomyopathy linked to reduced PPARδ activity; non-synonymous NCOA6 mutations were found in ~10% of idiopathic dilated cardiomyopathy patients (PMID:12556486, PMID:12368298, PMID:25131203).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2000 Medium

    Established NCOA6 as a bona fide nuclear receptor coactivator, defining the LXXLL-based interaction and an intrinsic activation domain as the basis of its transcriptional enhancement.

    Evidence In vitro binding and transient transfection reporter assays in cells

    PMID:10681503

    Open questions at the time
    • Did not resolve which endogenous target genes are controlled
    • No structural or in vivo functional context
  2. 2002 High

    Identified NIF-1 as a direct NCOA6 partner that extends coactivation to c-Fos/c-Jun, framing NCOA6 as the core of a larger cotransducer complex rather than a standalone bridge.

    Evidence Yeast two-hybrid, reciprocal Co-IP, in vitro binding, reporter assays

    PMID:12215545

    Open questions at the time
    • Composition of the full NCOA6/NIF-1 complex unresolved
    • Endogenous target loci not mapped
  3. 2002 High

    Knockout established NCOA6 as developmentally essential and non-redundant with other coactivators, tying lethality to placental and cardiac failure and reduced PPARγ activity.

    Evidence Two independent mouse knockouts, histology, PPARγ transcriptional assays in MEFs

    PMID:12368298 PMID:12556486

    Open questions at the time
    • Mechanism distinguishing placental vs cardiac requirement unclear
    • Direct chromatin recruitment not assessed
  4. 2004 High

    Demonstrated that NCOA6 is a pro-survival coregulator whose loss triggers apoptosis, linking its coactivator function to cell viability beyond transcriptional output.

    Evidence KO/siRNA MEF apoptosis assays and heterozygous mouse phenotyping

    PMID:15143190

    Open questions at the time
    • Apoptotic effector pathway downstream of NCOA6 loss not defined
    • Survival target genes unidentified
  5. 2007 Medium

    Domain dissection assigned dimerization and activation functions to specific regions and expanded NCOA6 coactivation to STAT-2 and p53, with p53 acting indirectly via Trap80–NIF-1.

    Evidence Deletion/mutation domain mapping, Co-IP, reporter assays

    PMID:17536006

    Open questions at the time
    • p53 link is indirect and not validated at endogenous targets
    • Single-lab domain assignments
  6. 2007 High

    In vivo motif mutagenesis showed individual LXXLL motifs are receptor- and tissue-specific, with LXXLL-2 dedicated to hepatic LXRα lipid metabolism but dispensable for ERα.

    Evidence Knock-in LXXLL-2 mutant mice, agonist treatment, metabolite and target-gene measurement

    PMID:17908797

    Open questions at the time
    • Roles of other LXXLL motifs in vivo not addressed here
    • Chromatin-level mechanism not examined
  7. 2008 High

    Defined NCOA6 as a TGF-β pathway coactivator binding Smad2/3 MH2 domains via LXXLL-2, providing a mechanism for nuclear-receptor/TGF-β cross-talk.

    Evidence Y2H, Co-IP, domain mutagenesis, reporter assays, KO MEF target-gene analysis

    PMID:18263591

    Open questions at the time
    • Genome-wide Smad-dependent targets not mapped
    • Physiological context of cross-talk untested
  8. 2008 Medium

    Connected the CCR4-NOT components CNOT6/CNOT9 to nuclear receptor coactivation through NIF-1–NCOA6, broadening the coactivator complex membership.

    Evidence Co-IP, siRNA rescue, endogenous target-gene qRT-PCR, reporter assays

    PMID:18180299

    Open questions at the time
    • Stoichiometry of NCOA6/NIF-1/CCR4-NOT assembly unknown
    • Single-lab evidence
  9. 2010 High

    Cell-autonomous lens models showed NCOA6 is required for fiber-cell differentiation and crystallin expression, with apoptosis through both p53-dependent and -independent routes.

    Evidence Dominant-negative transgenic and conditional KO lens models, p53 epistasis, apoptosis markers

    PMID:20484573

    Open questions at the time
    • Direct NCOA6 target genes in lens not defined
    • Receptor partner driving differentiation unclear
  10. 2011 Medium

    Showed NCOA6 bridges two transcription factors on a single promoter, mediating PXR/HNF4α synergy at CYP2C9 with gene specificity.

    Evidence Y2H, GST pulldown, mammalian two-hybrid, ChIP, siRNA, reporter assays

    PMID:21292004

    Open questions at the time
    • Mechanism of promoter selectivity (CYP2C9 vs CYP3A4) unexplained
    • Single-lab study
  11. 2014 High

    Placed NCOA6 in the Trr/MLL-family H3K4 methyltransferase complex and as a direct Yorkie partner required for Hippo-pathway target H3K4 methylation, linking coactivation to a defined chromatin-modifying activity.

    Evidence Co-IP/pulldown, genetic epistasis, TEAD-tethering, ChIP H3K4me at target loci in Drosophila

    PMID:25027438

    Open questions at the time
    • Conservation of Yki/YAP–NCOA6 link in mammals not tested here
    • Methyltransferase subunit interactions not biochemically mapped
  12. 2014 High

    Connected NCOA6 to cardiac function and human disease, tying dilated cardiomyopathy to impaired PPARδ-driven mitochondrial gene programs and identifying patient mutations.

    Evidence Two mouse models, echocardiography, mitochondrial assays, PPARδ target expression, patient sequencing

    PMID:25131203

    Open questions at the time
    • Functional impact of specific patient variants not characterized
    • Direct PPARδ chromatin recruitment in heart not shown
  13. 2019 High

    Resolved the chromatin mechanism: NCOA6 constitutively maintains enhancer-promoter looping and, upon estrogen, recruits ERα, p300, MLL4 and Pol II to deposit activating histone marks and drive transcription.

    Evidence CRISPR KO, ChIP/ChIP-seq, chromosome conformation capture, histone-mark and Pol II analysis

    PMID:31744881

    Open questions at the time
    • Generality of constitutive looping role at other loci untested
    • Order of recruitment events not fully dissected

Open questions

Synthesis pass · forward-looking unresolved questions
  • How NCOA6 selects specific transcription-factor partners and target loci across tissues, and how its distinct LXXLL motifs and activation domains are deployed combinatorially in vivo, remains unresolved.
  • No genome-wide partner-resolved binding map across cell types
  • Structural basis of motif/partner specificity unknown
  • Causality of human DCM variants uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 4 GO:0060090 molecular adaptor activity 2
Localization
GO:0000228 nuclear chromosome 2 GO:0005634 nucleus 2
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-1430728 Metabolism 3 R-HSA-162582 Signal Transduction 2 R-HSA-4839726 Chromatin organization 2 R-HSA-74160 Gene expression (Transcription) 2
Partners
ESR1HNF4ANIF-1PXRSMAD2SMAD3SREBF1YORKIE/YKI
Complex memberships
Trr/MLL4 H3K4 methyltransferase complex

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 RAP250 (NCOA6) interacts with nuclear receptors in a ligand-dependent or ligand-enhanced manner through a single LXXLL motif (nuclear receptor box), and contains a potent glutamine-rich N-terminal activation domain that enhances transcriptional activity of multiple nuclear receptors. In vitro binding assays and transient transfection/reporter assays The Journal of biological chemistry Medium 10681503
2002 NRC-interacting factor 1 (NIF-1) directly interacts with NRC (NCOA6) in vivo and in vitro, and enhances ligand-dependent transcriptional activation by nuclear hormone receptors, c-Fos, and c-Jun through NRC, defining NIF-1 as a cotransducer that functions as part of or downstream of an NRC coactivator complex. Yeast two-hybrid cloning, reciprocal co-immunoprecipitation (in vivo), in vitro binding assays, transient transfection reporter assays Molecular and cellular biology High 12215545
2003 Genetic deletion of Rap250 (NCOA6) in mice causes embryonic lethality at E13.5 with dramatically reduced spongiotrophoblast layer and collapse of placental blood vessels; transcriptional activity of PPARγ is reduced in Rap250-null fibroblasts, indicating RAP250 is an essential coactivator for PPARγ in placental development. Gene targeting/knockout in mice, histological analysis, embryonic fibroblast transcriptional assays Molecular and cellular biology High 12368298 12556486
2002 AIB3/NCOA6 deletion in mice causes embryonic lethality at E9.75–11.5 due to failure of placental labyrinthine development and cardiac hypoplasia, and significantly reduces PPARγ transcriptional activity in mouse embryonic fibroblasts, demonstrating non-redundancy with PBP/TRAP220 and SRC coactivators. Homologous recombination knockout in mice, histological analysis, transcriptional activity assays in MEFs The Journal of biological chemistry High 12368298
2004 NRC (NCOA6) is required for cell survival: NRC-/- mouse embryonic fibroblasts undergo high-rate spontaneous apoptosis, and siRNA knockdown of NRC in wild-type MEFs enhances apoptosis, establishing NRC as a pro-survival/anti-apoptotic coregulator. NRC+/- mice on the 129S6 background show infertility, growth retardation, and a spontaneous wound healing defect. MEF derivation from knockout embryos, siRNA knockdown, apoptosis assays, phenotypic analysis of heterozygous mice Molecular and cellular biology High 15143190
2007 NRC (NCOA6) dimerizes through a 146-amino-acid region including LxxLL-1; the activation domain AD2 (just C-terminal to LxxLL-1) is central for ligand-dependent nuclear receptor activation even though AD1 has greater intrinsic activity; NRC also functions as a coactivator for STAT-2 and p53, with p53 activation mediated indirectly through Trap80–NIF-1–NRC interaction. Domain mapping by deletion/mutation analysis, co-immunoprecipitation, reporter/transcriptional assays Molecular endocrinology Medium 17536006
2007 The C-terminal LXXLL-2 motif of NCoA6 (NCOA6) is specifically required for LXRα-regulated lipogenesis and cholesterol/bile acid homeostasis in the liver, but is dispensable for ERα function in mammary gland, demonstrating tissue- and nuclear receptor-specific roles of this motif in vivo. Knock-in mice carrying LXXLL-2 to AXXAL mutation, LXRα agonist treatment, target gene expression analysis, biochemical measurements of cholesterol and bile acids Molecular and cellular biology High 17908797
2008 CCR4/CNOT6 and RCD1/CNOT9 (members of the CCR4-NOT complex) function as nuclear hormone receptor coactivators through interaction with NIF-1 (the NRC-interacting factor); CCR4 associates with NIF-1 in vivo and its coactivator effect on nuclear receptors (including RARα target genes Sox9 and HoxA1) is dependent on NIF-1, which in turn interacts with NRC (NCOA6). Co-immunoprecipitation (in vivo and in vitro), siRNA knockdown, reporter assays, qRT-PCR of endogenous target genes The Journal of biological chemistry Medium 18180299
2008 RAP250 (NCOA6) directly interacts with Smad2 and Smad3 via its second LXXLL motif (interacting with the Smad MH2 domain), acts as a coactivator in TGF-β signaling, and mediates cross-talk between TGF-β and LXR signaling pathways; RAP250-null MEFs show reduced PAI-1 expression after TGF-β stimulation. Yeast two-hybrid screen, co-immunoprecipitation, domain mapping (LXXLL mutants, MH2 domain), luciferase reporter assays, RAP250-null MEF analysis The Journal of biological chemistry High 18263591
2010 Expression of a dominant-negative fragment of NCOA6 (dnNCOA6, containing the N-terminal LXXLL motif) in transgenic mouse lens fiber cells causes reduced growth, disrupted fiber cell differentiation, impaired gamma-crystallin expression, cataract, and stalled denucleation (karyolysis), with apoptosis proceeding through both p53-dependent and p53-independent pathways; lens-specific conditional deletion of Ncoa6 also disrupts fiber cell differentiation, establishing a cell-autonomous role. Transgenic dominant-negative expression, lens-specific conditional knockout, genetic epistasis with p53 null background, caspase-3 activation, γ-H2AX and TUNEL assays Molecular biology of the cell High 20484573
2014 Drosophila Ncoa6, a subunit of the Trithorax-related (Trr) histone H3K4 methyltransferase complex, is a direct binding partner of the Hippo pathway transcriptional coactivator Yorkie (Yki); Ncoa6, Trr, and Yki are all required for Hippo-mediated growth control and target gene expression; artificial tethering of Ncoa6 to the TEAD factor Scalloped (Sd) promotes tissue overgrowth even without Yki, and Yki/Ncoa6/Trr are required for normal H3K4 methylation at Hippo target gene loci. Protein interaction (co-IP/pulldown), genetic epistasis (loss-of-function), targeted tethering experiment, ChIP-based H3K4me measurement at target loci eLife High 25027438
2014 Perturbation of NCOA6 (germline or cardiac-specific depletion) in mice causes severe dilated cardiomyopathy with impaired mitochondrial function and reduced activity of PPARδ, an NCOA6 target nuclear receptor critical for normal heart function; three independent non-synonymous NCOA6 mutations were identified in 10% of idiopathic DCM patients. Two independent mouse models (germline and cardiac-specific conditional KO/hypomorphic), echocardiography, mitochondrial function assays, PPARδ target gene expression, human patient sequencing Cell reports High 25131203
2011 NCOA6 is required for synergistic activation of CYP2C9 by PXR and HNF4α: NCOA6 interacts with HNF4α (identified by two-hybrid screen) and with PXR through its first LXXLL motif (GST pulldown and mammalian two-hybrid), bridges the HNF4α and PXR binding sites on the CYP2C9 promoter (ChIP), and its silencing abolishes synergistic induction of CYP2C9 but not CYP3A4. Yeast two-hybrid, GST pulldown, mammalian two-hybrid, ChIP, siRNA knockdown, promoter-reporter assays Pharmacological research Medium 21292004
2017 NCOA6 regulates Nampt (nicotinamide phosphoribosyltransferase) expression in pancreatic β-cells by cooperating with SREBP-1c at the Nampt promoter SRE element; ChIP confirmed direct NCOA6 recruitment to the SRE region; treatment with NMN (Nampt reaction product) partially rescues impaired glucose-stimulated insulin secretion in NCOA6+/- islets. Islet transcriptomics (NCOA6+/- vs +/+), promoter-reporter assays with SREBP-1c and NCOA6 co-expression, mutant promoter analysis, ChIP, NMN rescue experiment Biochemical and biophysical research communications Medium 28435063
2019 NCOA6 is essential for estradiol/ERα-activated GREB1 transcription in endometrial cells: NCOA6 associates with the GREB1 promoter and enhancer in an E2-independent manner, maintains chromatin looping and enhancer-promoter interactions at basal state, and upon E2 stimulation recruits ERα, p300, MLL4, and RNA Pol II to drive H3K4me1/3, H3K9ac, and H3K27ac increases and robust GREB1 transcription; NCOA6 knockout abolishes all these events. NCOA6 knockout (CRISPR), ChIP-seq/ChIP, chromosome conformation capture (chromatin looping), RNA Pol II and histone modification analysis, reporter assays The Journal of biological chemistry High 31744881

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 Genome sequence of Halobacterium species NRC-1. Proceedings of the National Academy of Sciences of the United States of America 539 11016950
2001 Understanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence. Genome research 253 11591641
2000 Cloning and characterization of RAP250, a novel nuclear receptor coactivator. The Journal of biological chemistry 120 10681503
2008 Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1. Genomics 107 18313895
2004 Systems level insights into the stress response to UV radiation in the halophilic archaeon Halobacterium NRC-1. Genome research 107 15140832
2004 Arsenic resistance in Halobacterium sp. strain NRC-1 examined by using an improved gene knockout system. Journal of bacteriology 103 15126481
2001 Synapse formation is arrested in retinal photoreceptors of the zebrafish nrc mutant. The Journal of neuroscience : the official journal of the Society for Neuroscience 92 11264308
2004 Halobacterium noricense sp. nov., an archaeal isolate from a bore core of an alpine Permian salt deposit, classification of Halobacterium sp. NRC-1 as a strain of H. salinarum and emended description of H. salinarum. Extremophiles : life under extreme conditions 90 15290323
2004 The zebrafish nrc mutant reveals a role for the polyphosphoinositide phosphatase synaptojanin 1 in cone photoreceptor ribbon anchoring. The Journal of neuroscience : the official journal of the Society for Neuroscience 89 15470129
1987 Anatoxin-a(s), an anticholinesterase from the cyanobacterium Anabaena flos-aquae NRC-525-17. Toxicon : official journal of the International Society on Toxinology 85 3124299
2003 Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Molecular and cellular biology 82 12556486
2002 Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality. The Journal of biological chemistry 75 12368298
2022 Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens. The EMBO journal 74 36579501
2007 Transcriptional profiling of the model Archaeon Halobacterium sp. NRC-1: responses to changes in salinity and temperature. Saline systems 71 17651475
2005 Genomic analysis of anaerobic respiration in the archaeon Halobacterium sp. strain NRC-1: dimethyl sulfoxide and trimethylamine N-oxide as terminal electron acceptors. Journal of bacteriology 71 15716436
2003 An archaeal chromosomal autonomously replicating sequence element from an extreme halophile, Halobacterium sp. strain NRC-1. Journal of bacteriology 71 14526006
1986 The pharmacology of anatoxin-a(s), a neurotoxin produced by the freshwater cyanobacterium Anabaena flos-aquae NRC 525-17. Toxicon : official journal of the International Society on Toxinology 69 3087030
2006 The uvrA, uvrB and uvrC genes are required for repair of ultraviolet light induced DNA photoproducts in Halobacterium sp. NRC-1. Saline systems 68 16970815
2005 UV irradiation induces homologous recombination genes in the model archaeon, Halobacterium sp. NRC-1. Saline systems 68 16176594
2023 Effector-dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi-amr3 and Rpi-amr1. The EMBO journal 67 36592032
2014 The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6. eLife 62 25027438
2007 Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1. BMC genetics 60 17559652
2003 Multiple replication origins of the archaeon Halobacterium species NRC-1. Biochemical and biophysical research communications 58 12646230
1998 The isolation and characterization of nrc-1 and nrc-2, two genes encoding protein kinases that control growth and development in Neurospora crassa. Genetics 57 9584090
2005 Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40 years later. Twin research and human genetics : the official journal of the International Society for Twin Studies 56 16176721
2014 Fungal communication requires the MAK-2 pathway elements STE-20 and RAS-2, the NRC-1 adapter STE-50 and the MAP kinase scaffold HAM-5. PLoS genetics 54 25411845
2001 Investigations of photoreceptor synaptic transmission and light adaptation in the zebrafish visual mutant nrc. Investigative ophthalmology & visual science 53 11222552
2008 Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development. Nuclear receptor signaling 51 18301782
2004 The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair. Molecular and cellular biology 50 15143190
2004 Complexity of gas vesicle biogenesis in Halobacterium sp. strain NRC-1: identification of five new proteins. Journal of bacteriology 48 15126480
2003 Proteomic analysis of an extreme halophilic archaeon, Halobacterium sp. NRC-1. Molecular & cellular proteomics : MCP 48 12872007
2017 nRC: non-coding RNA Classifier based on structural features. BioData mining 46 28785313
1998 Multiple threshold model for the onset of Alzheimer's disease in the NAS-NRC twin panel. American journal of medical genetics 46 9514594
2009 Salt shield: intracellular salts provide cellular protection against ionizing radiation in the halophilic archaeon, Halobacterium salinarum NRC-1. Environmental microbiology 45 19452594
2013 Production and characterization of thermostable metallo-keratinase from newly isolated Bacillus subtilis NRC 3. International journal of biological macromolecules 43 23313822
2005 Production of levansucrase from Bacillus subtilis NRC 33a and enzymic synthesis of levan and Fructo-Oligosaccharides. Current microbiology 41 16328628
2001 Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon. Photosynthesis research 41 16228359
2008 Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. The Journal of biological chemistry 39 18180299
2022 Cationic antimicrobial peptide NRC-03 induces oral squamous cell carcinoma cell apoptosis via CypD-mPTP axis-mediated mitochondrial oxidative stress. Redox biology 37 35660629
2010 Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Molecular biology of the cell 35 20484573
1999 The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation. Cancer research 35 10232606
2013 Anti-microbial, anti-biofilm activities and cell selectivity of the NRC-16 peptide derived from witch flounder, Glyptocephalus cynoglossus. Marine drugs 34 23760014
2006 Post-genomics of the model haloarchaeon Halobacterium sp. NRC-1. Saline systems 34 16542428
2002 NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. Molecular and cellular biology 34 12215545
2004 Identification of the first archaeal Type 1 RNase H gene from Halobacterium sp. NRC-1: archaeal RNase HI can cleave an RNA-DNA junction. The Biochemical journal 33 15115438
2004 Comprehensive de novo structure prediction in a systems-biology context for the archaea Halobacterium sp. NRC-1. Genome biology 33 15287974
2009 Global protein-level responses of Halobacterium salinarum NRC-1 to prolonged changes in external sodium chloride concentrations. Journal of proteome research 32 19206189
2003 The cobY gene of the archaeon Halobacterium sp. strain NRC-1 is required for de novo cobamide synthesis. Journal of bacteriology 32 12486068
2023 An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana. PLoS genetics 31 36656829
2010 MutS and MutL are dispensable for maintenance of the genomic mutation rate in the halophilic archaeon Halobacterium salinarum NRC-1. PloS one 31 20140215
2007 Global analysis of mRNA decay in Halobacterium salinarum NRC-1 at single-gene resolution using DNA microarrays. Journal of bacteriology 31 17644597
2008 Rad50 is not essential for the Mre11-dependent repair of DNA double-strand breaks in Halobacterium sp. strain NRC-1. Journal of bacteriology 29 18502851
2011 Can case study approaches speed implementation of the NRC report: "Toxicity Testing in the 21st Century: A Vision and a Strategy?". ALTEX 28 21993955
2007 Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice. Molecular and cellular biology 28 17908797
2005 ABC transporter for corrinoids in Halobacterium sp. strain NRC-1. Journal of bacteriology 28 16109931
2013 Metabolic characteristics of the proteins in yellow-seeded and brown-seeded canola meal and presscake in dairy cattle: comparison of three systems (PDI, DVE, and NRC) in nutrient supply and feed milk value (FMV). Journal of agricultural and food chemistry 27 23410190
2009 Multiple replication origins of Halobacterium sp. strain NRC-1: properties of the conserved orc7-dependent oriC1. Journal of bacteriology 25 19502403
2006 Proteomic analysis of acidic chaperones, and stress proteins in extreme halophile Halobacterium NRC-1: a comparative proteomic approach to study heat shock response. Proteome science 25 16623945
2019 Whole-genome comparison between the type strain of Halobacterium salinarum (DSM 3754T ) and the laboratory strains R1 and NRC-1. MicrobiologyOpen 23 31797576
2015 Enhanced killing of breast cancer cells by a d-amino acid analog of the winter flounder-derived pleurocidin NRC-03. Experimental and molecular pathology 22 26344617
2015 The Survival and Resistance of Halobacterium salinarum NRC-1, Halococcus hamelinensis, and Halococcus morrhuae to Simulated Outer Space Solar Radiation. Astrobiology 22 26539978
2008 RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. The Journal of biological chemistry 22 18263591
2008 Transcriptional responses to biologically relevant doses of UV-B radiation in the model archaeon, Halobacterium sp. NRC-1. Saline systems 22 18759987
1997 Development of neo red cells (NRC) with the enzymatic reduction system of methemoglobin. Artificial cells, blood substitutes, and immobilization biotechnology 22 9242936
2014 Perturbation of NCOA6 leads to dilated cardiomyopathy. Cell reports 21 25131203
2012 Genome-wide responses of the model archaeon Halobacterium sp. strain NRC-1 to oxygen limitation. Journal of bacteriology 21 22865851
2019 A Bi-Functional Targeted P28-NRC Chimeric Protein with Enhanced Cytotoxic Effects on Breast Cancer Cell Lines. Iranian journal of pharmaceutical research : IJPR 20 31531057
2014 Circular dichroism and fluorescence spectroscopy of cysteinyl-tRNA synthetase from Halobacterium salinarum ssp. NRC-1 demonstrates that group I cations are particularly effective in providing structure and stability to this halophilic protein. PloS one 20 24594651
2012 High-pressure tolerance in Halobacterium salinarum NRC-1 and other non-piezophilic prokaryotes. Extremophiles : life under extreme conditions 18 22212652
2012 Overexpression in a non-native halophilic host and biotechnological potential of NAD+-dependent glutamate dehydrogenase from Halobacterium salinarum strain NRC-36014. Extremophiles : life under extreme conditions 18 22527040
2004 Building beef cow nutritional programs with the 1996 NRC beef cattle requirements model. Journal of animal science 18 15471818
2024 The nucleotide-binding domain of NRC-dependent disease resistance proteins is sufficient to activate downstream helper NLR oligomerization and immune signaling. The New phytologist 17 38757730
2006 Evaluation of the passage rate equations in the 2001 Dairy NRC model. Journal of dairy science 17 16702300
2002 The NAS-NRC Twin Registry of WWII military veteran twins. National Academy of Sciences-National Research Council. Twin research : the official journal of the International Society for Twin Studies 17 12537883
2021 Characterization of the Roles of SGT1/RAR1, EDS1/NDR1, NPR1, and NRC/ADR1/NRG1 in Sw-5b-Mediated Resistance to Tomato Spotted Wilt Virus. Viruses 16 34452313
2024 NRC Immune receptor networks show diversified hierarchical genetic architecture across plant lineages. The Plant cell 15 38922300
2019 Characterization of a new efficient low molecular weight Bacillus subtilis NRC 16 levansucrase and its levan. Journal of basic microbiology 15 31407369
2019 The transcriptional co-activator NCOA6 promotes estrogen-induced GREB1 transcription by recruiting ERα and enhancing enhancer-promoter interactions. The Journal of biological chemistry 14 31744881
2009 Carboxyl ester hydrolases production and growth of a halophilic archaeon, Halobacterium sp. NRC-1. Extremophiles : life under extreme conditions 14 19957092
2020 Dietary intake of amino acids and vitamins compared to NRC requirements in obese cats undergoing energy restriction for weight loss. BMC veterinary research 12 33160364
2019 The Primary Antisense Transcriptome of Halobacterium salinarum NRC-1. Genes 12 30959844
2017 The Effects of HZE Particles, γ and X-ray Radiation on the Survival and Genetic Integrity of Halobacterium salinarum NRC-1, Halococcus hamelinensis, and Halococcus morrhuae. Astrobiology 12 28151694
2007 Nuclear receptor coregulator (NRC): mapping of the dimerization domain, activation of p53 and STAT-2, and identification of the activation domain AD2 necessary for nuclear receptor signaling. Molecular endocrinology (Baltimore, Md.) 12 17536006
2023 Antibacterial and in vitro anticancer activities of the antimicrobial peptide NRC-07 encapsulated in chitosan nanoparticles. Journal of peptide science : an official publication of the European Peptide Society 11 37853814
2018 A new l-glutaminase from Streptomyces pratensis NRC 10: Gene identification, enzyme purification, and characterization. International journal of biological macromolecules 11 29458104
2000 World population data for the HLA-DQA1, PM and D1S80 loci with least and most common profile frequencies for combinations of loci estimated following NRC II guidelines. Journal of forensic sciences 11 10641927
2011 Regulatory multidimensionality of gas vesicle biogenesis in Halobacterium salinarum NRC-1. Archaea (Vancouver, B.C.) 10 22110395
1994 Comments on the statistical aspects of the NRC's report on DNA typing. Journal of forensic sciences 10 8113709
2021 Bioreduction of hexavalent chromium by a novel haloalkaliphilic Salipaludibacillus agaradhaerens strain NRC-R isolated from hypersaline soda lakes. 3 Biotech 9 34956810
2019 The Genome Sequence of the Halobacterium salinarum Type Strain Is Closely Related to That of Laboratory Strains NRC-1 and R1. Microbiology resource announcements 9 31296677
2012 A dual role of divalent metal ions in catalysis and folding of RNase H1 from extreme halophilic archaeon Halobacterium sp. NRC-1. FEBS open bio 9 23772368
2001 Evaluation of the 1996 NRC beef model under western Canadian environmental conditions. Journal of animal science 9 11204711
1998 Oxygen carrying capacity and oxygen supply rate of artificial oxygen carrier, Neo Red Cell (NRC). Artificial cells, blood substitutes, and immobilization biotechnology 9 9844712
2022 Bioengineering of Halobacterium sp. NRC-1 gas vesicle nanoparticles with GvpC fusion protein produced in E. coli. Applied microbiology and biotechnology 8 35230496
2016 Expression and purification of toxic anti-breast cancer p28-NRC chimeric protein. Advanced biomedical research 8 27169101
2011 NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes. Pharmacological research 8 21292004
2009 Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis. Biochemical and biophysical research communications 8 19799870
2020 Evaluation of predicted ration nutritional values by NRC (2001) and INRA (2018) feed evaluation systems, and implications for the prediction of milk response. Journal of dairy science 7 33010908
2017 Regulation of Nampt expression by transcriptional coactivator NCOA6 in pancreatic β-cells. Biochemical and biophysical research communications 7 28435063
1999 Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling. The journal of peptide research : official journal of the American Peptide Society 7 10231710

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