Affinage

MYO15A

Unconventional myosin-XV · UniProt Q9UKN7

Length
3530 aa
Mass
395.3 kDa
Annotated
2026-04-29
68 papers in source corpus 14 papers cited in narrative 14 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MYO15A encodes myosin XVA, an unconventional myosin motor essential for the development, elongation, and maintenance of stereocilia in inner ear hair cells, and loss-of-function mutations cause autosomal recessive nonsyndromic deafness DFNB3 (PMID:9603736, PMID:16580798). The protein contains a conserved motor domain with moderate duty ratio (~0.5) and slow ADP release kinetics consistent with processive cargo transport (PMID:33372036), an N-terminal extension unique to isoform 1, and tandem MyTH4-FERM-SH3 tail domains that mediate delivery of the Whirlin–Eps8 elongation-promoting complex to stereocilia tips, where the complex forms liquid-liquid phase separation condensates that drive actin bundling (PMID:33626355, PMID:10552926). Distinct MYO15A isoforms fulfill temporally separated roles: isoform 2 drives developmental stereocilia elongation, isoform 1 tunes postnatal size of shorter mechanosensitive stereocilia, and isoform 3 maintains adult stereocilia architecture after a postnatal handover from isoform 2 (PMID:40027801, PMID:9603736, PMID:17546645). MYO15A functions in a pathway independent of other hair cell myosins (MYO6, MYO7A) and is additionally required for mechanotransduction-dependent remodeling of the stereocilia actin cytoskeleton (PMID:12966030).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1998 High

    Identifying MYO15A as the DFNB3 deafness gene established that an unconventional myosin is essential for auditory function, opening the question of what cellular role it plays in the inner ear.

    Evidence Positional cloning with mutation co-segregation across three unrelated families with congenital recessive deafness

    PMID:9603736

    Open questions at the time
    • Cellular localization and domain function unknown
    • Protein not yet visualized in hair cells
    • No functional assay for motor activity
  2. 1999 High

    Full-length sequencing revealed a complex multi-domain architecture (unique N-terminal extension, motor, MyTH4-FERM-SH3 tail) and immunolocalization to stereocilia and cuticular plate, linking the motor to actin-rich hair cell structures.

    Evidence cDNA/genomic sequencing, Northern blot, immunostaining of mouse organ of Corti

    PMID:10552926

    Open questions at the time
    • Cargo and binding partners of tail domains not identified
    • Motor enzymatic properties unknown
    • Subcellular trafficking mechanism to stereocilia tips uncharacterized
  3. 2003 High

    Genetic epistasis experiments placed Myo15 in a pathway independent of Myo6, Myo7a, and pirouette, establishing that stereocilia development requires multiple non-redundant myosin pathways.

    Evidence Double-mutant mouse crosses with ABR testing and cochlear histology

    PMID:12966030

    Open questions at the time
    • Specific cargo or effectors unique to the Myo15 pathway not identified
    • Temporal requirement during development versus maintenance not resolved
  4. 2006 High

    BAC transgene rescue of shaker-2 mice proved that Myo15a expression is sufficient to restore hearing and stereocilia morphology, confirming a cell-autonomous hair cell function.

    Evidence BAC transgene insertion into sh2 mice; ABR and cochlear morphology over 6 months

    PMID:16580798

    Open questions at the time
    • Minimal expression construct or critical domains for rescue not determined
    • Whether rescue extends beyond 6 months unknown
  5. 2007 High

    Identification of truncating mutations within the isoform 1-specific exon 2 demonstrated that the large N-terminal extension is functionally required for hearing, establishing isoform-specific functional requirements.

    Evidence Mutational analysis with co-segregation in multiple deaf families

    PMID:17546645

    Open questions at the time
    • Biochemical function of the N-terminal extension unknown
    • Whether shorter isoforms can partially compensate not tested
  6. 2016 High

    CRISPR correction of MYO15A mutations in iPSC-derived hair cell-like cells rescued morphology and function, establishing a human cell-autonomous model and confirming causality of specific compound heterozygous mutations.

    Evidence iPSC differentiation to hair cell-like cells; CRISPR/Cas9 correction with morphological and functional readouts

    PMID:26915297

    Open questions at the time
    • iPSC-derived hair cells may not fully recapitulate in vivo stereocilia architecture
    • Specific molecular defect at the stereocilia level not resolved
  7. 2021 High

    Reconstitution of the Whirlin–MYO15–Eps8 complex revealed that tip complex density formation occurs via liquid-liquid phase separation that promotes actin bundling, and a deafness mutation disrupts condensate formation, providing the first molecular mechanism linking MYO15A tail interactions to stereocilia elongation.

    Evidence In vitro reconstitution of protein complex; phase separation and actin bundling assays; deafness-associated mutant characterization

    PMID:33626355

    Open questions at the time
    • Whether LLPS occurs in vivo at stereocilia tips not directly shown
    • Stoichiometry and regulation of condensate formation in cells unclear
  8. 2021 High

    Comprehensive transient kinetic analysis of the MYO15 motor domain revealed a moderate duty ratio (~0.5) and rate-limiting ADP release, providing a biophysical basis for how MYO15A could achieve processive transport when oligomerized.

    Evidence Recombinant S1 expressed in Sf9 cells; stopped-flow and quenched-flow kinetics

    PMID:33372036

    Open questions at the time
    • Processivity of full-length or dimerized MYO15A not measured
    • How cargo binding affects motor kinetics unknown
    • Step size and force generation not determined
  9. 2025 High

    Discovery of a third isoform (MYO15A-3) that takes over from MYO15A-2 postnatally to maintain the elongation-promoting complex at stereocilia tips resolved the long-standing question of how stereocilia are maintained in adulthood and showed that isoform switching is critical for progressive hearing preservation.

    Evidence Isoform-specific Myo15a-3 knockout mice; immunofluorescence, ABR, SEM (preprint)

    PMID:40027801

    Open questions at the time
    • Mechanism triggering the isoform developmental switch unknown
    • Whether MYO15A-1 and MYO15A-3 have distinct cargo preferences not resolved
    • Preprint awaiting peer review

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of full-length MYO15A processivity and cargo engagement, how LLPS condensates are regulated in vivo, the function of the N-terminal extension of isoform 1, and whether gene therapy targeting MYO15A can restore hearing in DFNB3 patients.
  • No crystal or cryo-EM structure of full-length MYO15A
  • In vivo LLPS regulation at stereocilia tips uncharacterized
  • Functional role of the ~1200-aa N-terminal extension remains biochemically undefined
  • No gene therapy rescue of MYO15A-related deafness demonstrated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003774 cytoskeletal motor activity 2 GO:0008092 cytoskeletal protein binding 2 GO:0140657 ATP-dependent activity 1
Localization
GO:0005856 cytoskeleton 3 GO:0005886 plasma membrane 3
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-9709957 Sensory Perception 3
Partners
EPS8WHRN
Complex memberships
Whirlin–MYO15A–Eps8 tip complex

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 MYO15A encodes an unconventional myosin (myosin XV) and mutations in this gene cause hereditary deafness DFNB3; the gene has at least 50 exons and two missense and one nonsense mutations co-segregated with congenital recessive deafness in three unrelated DFNB3 families, establishing MYO15A as the DFNB3 disease gene. Positional and functional cloning; mutation analysis in affected families Science High 9603736
1999 Full-length myosin XV transcripts contain 66 exons, encode ~365 kDa proteins with a unique ~1200-aa N-terminal extension preceding the conserved motor domain, two MyTH4 domains, two FERM-like regions, and a putative SH3 domain; MYO15A protein is concentrated in the cuticular plate and stereocilia of cochlear sensory hair cells, implicating it in formation or maintenance of actin-rich structures of inner ear hair cells. cDNA/genomic sequence analysis; Northern blot; in situ hybridization; immunostaining of adult mouse organ of Corti Genomics High 10552926
2003 Myo15 function in stereocilia development is distinct from Myo6, Myo7a, and pirouette gene functions; double mutant mice display superimposition of single-mutant stereocilia phenotypes without additive hearing loss in heterozygotes, placing Myo15 in a pathway independent of these other myosins. Genetic epistasis via double-mutant crosses; auditory brainstem response testing; cochlear histology Human molecular genetics High 12966030
2006 BAC transgene insertion of Myo15a into shaker-2 (sh2) mutant mice (which lack functional myosin XV) rescues normal hearing, normal stereocilia morphology, and abolishes circling behavior, demonstrating that Myo15a expression in hair cells is sufficient to maintain cochlear structure and function for at least 6 months. BAC transgene rescue; auditory brainstem response; cochlear morphology at 2, 4, 6 months Hearing research High 16580798
2007 The large N-terminal extension of myosin XVA encoded by alternatively-spliced exon 2 (isoform 1, ~1203 residues) is functionally required for normal hearing; truncating mutations within exon 2 cause severe-to-profound deafness in humans, establishing that isoform 1 is not dispensable. Mutational analysis of affected families; co-segregation of exon 2 truncating mutations with hearing loss phenotype Human mutation High 17546645
2007 A missense mutation p.Gly1831Val in the motor domain of MYO15A is predicted by molecular modeling to inhibit the powerstroke by reducing backbone flexibility and weakening hydrophobic interactions necessary for signal transmission to the converter domain, providing mechanistic insight into how a motor domain mutation disrupts myosin XV function. Mutation identification by sequencing; molecular modeling of motor head domain American journal of medical genetics. Part A Low 17853461
2011 A leucine-to-proline substitution in exon 56 of Myo15 within the C-terminal MyTH4 domain of the tail region causes deafness and retinal degeneration in LEW/Ztm-ci2 rats; Myo15 mRNA is expressed in the retina (demonstrated by in situ hybridization and PCR for the first time), showing that mutations in MyTH4 binding domains can cause syndromic rather than only non-syndromic hearing loss. Mutation identification (sequencing of exon 56); in situ hybridization and PCR for retinal expression; electroretinography; histological analysis of retina PloS one Medium 21479269
2021 The Whirlin–myosin 15 (MYO15)–Eps8 complex forms tip complex density (TCD)-like condensates at the distal tips of stereocilia through liquid-liquid phase separation driven by specific multivalent interactions; the reconstituted condensates promote actin bundling, and a deafness-associated MYO15 mutation interferes with condensate formation and impairs actin bundling. Reconstitution of protein complex; in vitro phase separation assay; actin bundling assay; mutagenesis of deafness-associated MYO15 variant Cell reports High 33626355
2021 The MYO15 motor domain (S1) has a mechanochemical ATPase cycle characterized by: kcat ~6 s⁻¹ at 20°C, actin-attached ADP release as the slowest measured step (~12 s⁻¹), a moderate duty ratio (~0.5), and weak thermodynamic coupling between ADP and actin binding, consistent with MYO15 being kinetically adapted for processive motility when oligomerized. Baculovirus-Sf9 recombinant expression; stopped-flow and quenched-flow transient kinetics; in vitro ATPase assay; co-expression with UNC45 and HSP90A chaperones The Journal of biological chemistry High 33372036
2016 MYO15A compound heterozygous mutations (c.4642G>A and c.8374G>A) in iPSC-derived hair cell-like cells cause abnormal morphology and dysfunction; CRISPR/Cas9-mediated genetic correction of the MYO15A mutations in iPSCs rescued both morphology and function of the derived hair cell-like cells, establishing a causal cell-autonomous role for MYO15A in hair cell function. iPSC generation from mutation carriers; hair cell differentiation; CRISPR/Cas9 correction; morphological and functional analysis of hair cell-like cells Cell death and differentiation High 26915297
2024 The hair cell-specific Myo15 promoter drives highly specific expression of transgenes in inner ear hair cells (but not other cell types) when used in AAV-PHP.eB vectors; this promoter-driven AAV system efficiently restored otoferlin expression and hearing in Otof⁻/⁻ mice, demonstrating its utility for specific hair cell gene therapy. AAV-mediated gene delivery with Myo15 promoter; GFP reporter assay; ABR hearing threshold measurement; otoferlin exocytosis functional assay in Otof knockout mice Molecular therapy. Nucleic acids Medium 38404504
2025 A third MYO15A isoform (MYO15A-3) is expressed postnatally in hair cells as MYO15A-2 expression wanes; MYO15A-2 initially delivers the elongation-promoting complex (EC) to stereocilia tips, followed by a postnatal handover to MYO15A-3; in Myo15a-3 mutant mice, stereocilia develop normally but lose the EC postnatally and fail to maintain adult architecture, causing progressive hearing loss. Isoform-specific mouse mutant (Myo15a-3 KO); immunofluorescence for EC complex targeting; auditory brainstem response; scanning electron microscopy of hair bundle morphology; expression analysis bioRxivpreprint High 40027801
2024 MYO15A isoforms are required for mechanotransduction (MET)-dependent remodeling of the actin cytoskeleton in transducing stereocilia; hair cells lacking all MYO15A isoforms show no MET-dependent remodeling, while cells lacking only the long isoform (MYO15A-1) show increased MET-dependent remodeling including in the tallest non-transducing row, demonstrating that MYO15A isoforms both enable and fine-tune activity-driven stereocilia plasticity. Electron microscopy of stereocilia cytoskeleton; pharmacological MET channel blockade in cochlear explants; isoform-specific Myo15a mutant mice bioRxivpreprint Medium bio_10.1101_2024.09.04.611210
2025 Introducing the jordan (jd) mutation (D-to-G substitution at the conserved actin-binding interface of MYO15A) into the homologous positions of DdMyo7 (Dictyostelium) and Myo10 significantly decreased filopodial initiation and tip intensity, demonstrating that the actin-binding interface of MyTH-FERM myosins including MYO15A is critical for reorganization of cortical actin during filopodia initiation. Site-directed mutagenesis of actin-binding interface; quantitative filopodia analysis (number, length, tip enrichment); live imaging in DdMyo7 and Myo10 systems bioRxivpreprint Low bio_10.1101_2025.05.29.656896

Source papers

Stage 0 corpus · 68 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3. Science (New York, N.Y.) 352 9603736
1995 A gene for congenital, recessive deafness DFNB3 maps to the pericentromeric region of chromosome 17. Nature genetics 186 7704031
1999 Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2. Genomics 137 10552926
2001 Novel mutations of MYO15A associated with profound deafness in consanguineous families and moderately severe hearing loss in a patient with Smith-Magenis syndrome. Human genetics 96 11735029
2016 Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation. Cell death and differentiation 78 26915297
2016 Mutational Spectrum of MYO15A and the Molecular Mechanisms of DFNB3 Human Deafness. Human mutation 72 27375115
2007 Mutational spectrum of MYO15A: the large N-terminal extension of myosin XVA is required for hearing. Human mutation 72 17546645
2012 Screening for MYO15A gene mutations in autosomal recessive nonsyndromic, GJB2 negative Iranian deaf population. American journal of medical genetics. Part A 47 22736430
1998 Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2. American journal of human genetics 43 9529344
2015 Mutations in the MYO15A gene are a significant cause of nonsyndromic hearing loss: massively parallel DNA sequencing-based analysis. The Annals of otology, rhinology, and laryngology 42 25792667
2010 Recurrent and private MYO15A mutations are associated with deafness in the Turkish population. Genetic testing and molecular biomarkers 40 20642360
2009 Mutations in the first MyTH4 domain of MYO15A are a common cause of DFNB3 hearing loss. The Laryngoscope 40 19274735
2007 MYO15A (DFNB3) mutations in Turkish hearing loss families and functional modeling of a novel motor domain mutation. American journal of medical genetics. Part A 39 17853461
2019 Genotype-phenotype correlation analysis of MYO15A variants in autosomal recessive non-syndromic hearing loss. BMC medical genetics 38 30953472
2009 Screening of the DFNB3 locus: identification of three novel mutations of MYO15A associated with hearing loss and further suggestion for two distinctive genes on this locus. Genetic testing and molecular biomarkers 35 19309289
2013 Whole-exome sequencing identifies MYO15A mutations as a cause of autosomal recessive nonsyndromic hearing loss in Korean families. BMC medical genetics 33 23865914
2011 Prioritized sequencing of the second exon of MYO15A reveals a new mutation segregating in a Pakistani family with moderate to severe hearing loss. European journal of medical genetics 33 22245518
2003 Myo15 function is distinct from Myo6, Myo7a and pirouette genes in development of cochlear stereocilia. Human molecular genetics 29 12966030
2015 Identification of a Novel MYO15A Mutation in a Chinese Family with Autosomal Recessive Nonsyndromic Hearing Loss. PloS one 28 26308726
2015 Identification and Clinical Implications of Novel MYO15A Mutations in a Non-consanguineous Korean Family by Targeted Exome Sequencing. Molecules and cells 27 26242193
2021 Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex. Cell reports 26 33626355
2024 Hair cell-specific Myo15 promoter-mediated gene therapy rescues hearing in DFNB9 mouse model. Molecular therapy. Nucleic acids 25 38404504
2013 Novel compound heterozygous mutations in the MYO15A gene in autosomal recessive hearing loss identified by whole-exome sequencing. Journal of translational medicine 23 24206587
2022 Exosomal microRNA-1 and MYO15A as a target for therapy and diagnosis in renal cell carcinoma. Biochemical and biophysical research communications 21 36150242
2017 MYO15A splicing mutations in hearing loss: A review literature and report of a novel mutation. International journal of pediatric otorhinolaryngology 20 28390610
2016 Targeted Resequencing of Deafness Genes Reveals a Founder MYO15A Variant in Northeastern Brazil. Annals of human genetics 19 27870113
2016 A novel founder MYO15A frameshift duplication is the major cause of genetic hearing loss in Oman. Journal of human genetics 18 27734841
2002 DFNB3, spectrum of MYO15A recessive mutant alleles and an emerging genotype-phenotype correlation. Advances in oto-rhino-laryngology 18 12408074
2017 Homozygous mutations in PJVK and MYO15A genes associated with non-syndromic hearing loss in Moroccan families. International journal of pediatric otorhinolaryngology 17 28964305
2019 Identification and Clinical Implications of a Novel MYO15A Variant in a Consanguineous Iranian Family by Targeted Exome Sequencing. Audiology & neuro-otology 16 30943474
2021 The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness. The Journal of biological chemistry 15 33372036
2024 Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear. Research (Washington, D.C.) 14 38665848
2019 Identification of novel variants in MYO15A, OTOF, and RDX with hearing loss by next-generation sequencing. Molecular genetics & genomic medicine 14 31250571
2015 A novel recessive truncating mutation in MYO15A causing prelingual sensorineural hearing loss. International journal of pediatric otorhinolaryngology 14 26810297
2021 Identification of Hearing Loss-Associated Variants of PTPRQ, MYO15A, and SERPINB6 in Pakistani Families. BioMed research international 13 33997018
2020 The worldwide frequency of MYO15A gene mutations in patients with non-syndromic hearing loss: A meta-analysis. Iranian journal of basic medical sciences 13 32774803
2021 A synonymous variant in MYO15A enriched in the Ashkenazi Jewish population causes autosomal recessive hearing loss due to abnormal splicing. European journal of human genetics : EJHG 12 33398081
2018 Three MYO15A Mutations Identified in One Chinese Family with Autosomal Recessive Nonsyndromic Hearing Loss. Neural plasticity 12 29849560
2006 Transgene correction maintains normal cochlear structure and function in 6-month-old Myo15a mutant mice. Hearing research 12 16580798
2021 Whole exome sequencing reveals pathogenic variants in MYO3A, MYO15A and COL9A3 and differential frequencies in ancestral alleles in hearing impairment genes among individuals from Cameroon. Human molecular genetics 11 33078831
2003 The circling behavior of the deafblind LEW-ci2 rat is linked to a segment of RNO10 containing Myo15 and Kcnj12. Mammalian genome : official journal of the International Mammalian Genome Society 10 14629112
2020 Whole exome sequencing identifies novel compound heterozygous pathogenic variants in the MYO15A gene leading to autosomal recessive non-syndromic hearing loss. Molecular biology reports 9 32623615
2016 Screening of DFNB3 in Iranian families with autosomal recessive non-syndromic hearing loss reveals a novel pathogenic mutation in the MyTh4 domain of the MYO15A gene in a linked family. Iranian journal of basic medical sciences 9 27635202
2023 Loss-of-function mutations in MYO15A and OTOF cause non-syndromic hearing loss in two Yemeni families. Human genomics 8 37189200
2020 Targeted Next-Generation Sequencing Identified Compound Heterozygous Mutations in MYO15A as the Probable Cause of Nonsyndromic Deafness in a Chinese Han Family. Neural plasticity 6 32617096
2016 Genetic Linkage Analysis of DFNB3, DFNB9 and DFNB21 Loci in GJB2 Negative Families with Autosomal Recessive Non-syndromic Hearing Loss. Iranian journal of public health 6 27398341
2002 Cloning and chromosomal localization of MYO15A to chromosome 5 of the dog (Canis familiaris). Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 6 12296523
2021 Hearing Features and Cochlear Implantation Outcomes in Patients With Pathogenic MYO15A Variants: a Multicenter Observational Study. Ear and hearing 5 34974475
2018 A novel nonsense mutation in MYO15A is associated with non-syndromic hearing loss: a case report. BMC medical genetics 5 30068307
2011 A mutation in Myo15 leads to Usher-like symptoms in LEW/Ztm-ci2 rats. PloS one 5 21479269
2022 Analysis of the genotype-phenotype correlation of MYO15A variants in Chinese non-syndromic hearing loss patients. BMC medical genomics 4 35346193
2020 Post-lingual non-syndromic hearing loss phenotype: a polygenic case with 2 biallelic mutations in MYO15A and MITF. BMC medical genetics 4 31898538
2019 Identification of a novel homozygous mutation in the MYO15A gene in a Kazakh family with non-syndromic hearing loss. International journal of pediatric otorhinolaryngology 4 31301639
2019 Report of a Novel Splicing Mutation in the MYO15A Gene in a Patient With Sensorineural Hearing Loss and Spectrum of the MYO15A Mutations. Clinical medicine insights. Case reports 4 31579092
2021 Identification of Novel and Recurrent Variants in MYO15A in Ashkenazi Jewish Patients With Autosomal Recessive Nonsyndromic Hearing Loss. Frontiers in genetics 3 34733312
2020 Investigation of MYO15A and MYO7A Mutations in Iranian Patients with Nonsyndromic Hearing Loss. Fetal and pediatric pathology 3 31997689
2020 Compound Heterozygous Mutations in TMC1 and MYO15A Are Associated with Autosomal Recessive Nonsyndromic Hearing Loss in Two Chinese Han Families. Neural plasticity 3 32802042
2025 Computational study of the potential impact of WHRN protein missense SNPs on WHRN-MYO15A protein complex interaction and their association with Usher syndrome. Journal of biomolecular structure & dynamics 2 40389825
2024 Novel compound heterozygous MYO15A splicing variants in autosomal recessive non-syndromic hearing loss. BMC medical genomics 2 38167320
2022 Identification of novel compound heterozygous mutations of the MYO15A gene with autosomal recessive non-syndromic hearing loss. Journal of clinical laboratory analysis 2 36217262
2021 Identification of Novel Compound Heterozygous MYO15A Mutations in Two Chinese Families with Autosomal Recessive Nonsyndromic Hearing Loss. Neural plasticity 2 34093702
2020 [Analysis of MYO15A variation in children with DFNB3]. Zhonghua er ke za zhi = Chinese journal of pediatrics 2 32987461
2013 Linkage study of DFNB3 responsible for hearing loss in human. Indian journal of human genetics 2 24339546
2025 A Myosin Nanomotor Essential for Stereocilia Maintenance Expands the Etiology of Hereditary Hearing Loss DFNB3. bioRxiv : the preprint server for biology 1 40027801
2025 The clinical and genetic spectrum of twenty-six individuals with hearing loss affected by MYO15A variants. Scientific reports 1 40275102
2024 A Novel Mutation Located in the N-Terminal Domain of MYO15A Caused Sensorineural Hearing Loss. Molecular genetics & genomic medicine 1 39620501
2024 A Novel Deleterious MYO15A Gene Mutation Causes Nonsyndromic Hearing Loss. Iranian journal of otorhinolaryngology 0 38259694
2024 [Genetic and phenotypic analysis of MYO15A rare variants associated with autosomal recessive hearing loss]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery 0 38297847