Affinage

MYO15A

Unconventional myosin-XV · UniProt Q9UKN7

Length
3530 aa
Mass
395.3 kDa
Annotated
2026-06-10
68 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MYO15A encodes an unconventional myosin (myosin XV) that acts as an actin-based molecular motor concentrated within the stereocilia and cuticular plate of cochlear sensory hair cells, where it builds and maintains the stereocilia actin architecture required for hearing (PMID:9603736, PMID:10552926). The protein is a ~365 kDa motor with a large N-terminal extension preceding a conserved motor domain and a tail bearing tandem MyTH4, FERM-like, and SH3 domains (PMID:10552926). Its minimal motor domain has a moderate duty ratio (~0.5) with ADP release from the actin-bound state as the rate-limiting transition, a kinetic profile consistent with processive motility when the motor is oligomerized (PMID:33372036). MYO15A delivers an elongation-promoting complex to stereocilia tips, and the Whirlin–myosin 15–Eps8 ternary complex assembles into tip-complex-density-like condensates through liquid-liquid phase separation that drives actin bundling; a deafness-associated MYO15A mutation abolishes condensate formation and impairs bundling (PMID:33626355). Distinct isoforms partition this work temporally: an isoform containing the exon 2–encoded N-terminal extension is required for stereocilia development, while a later-appearing isoform takes over complex delivery postnatally to maintain adult stereocilia, and MYO15A also participates in mechanotransduction-dependent remodeling of the stereocilia cytoskeleton [PMID:27375115, PMID:40027801, PMID:bio_10.1101_2024.09.04.611210]. Loss-of-function and splice-altering mutations in MYO15A cause DFNB3 autosomal recessive non-syndromic deafness through either developmental or maintenance defects, with genotype determining congenital-profound versus progressive post-lingual phenotypes (PMID:9603736, PMID:27375115, PMID:33398081).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1998 High

    Established MYO15A as a deafness gene, answering whether an unconventional myosin underlies a defined hereditary hearing loss locus.

    Evidence Positional cloning and exon sequencing in three unrelated DFNB3 families

    PMID:9603736

    Open questions at the time
    • Did not define protein domain architecture
    • No subcellular localization or cellular mechanism
  2. 1999 High

    Defined the protein as a ~365 kDa myosin with a unique N-terminal extension and MyTH4/FERM/SH3 tail, and localized it to hair cell stereocilia and cuticular plate, framing where and how it might act.

    Evidence cDNA/genomic analysis, in situ hybridization, and immunostaining of mouse organ of Corti

    PMID:10552926

    Open questions at the time
    • No motor kinetics
    • Binding partners and cargo unknown
    • Function of domains not tested
  3. 2003 High

    Showed Myo15 acts in a pathway distinct from other stereocilia myosins, clarifying that it is not redundant with Myo6, Myo7a, or pirouette.

    Evidence Double-mutant mouse epistasis with hearing and cochlear morphology readouts

    PMID:12966030

    Open questions at the time
    • Did not identify the molecular cargo of the independent pathway
  4. 2006 High

    Demonstrated Myo15a is necessary and sufficient for normal stereocilia and hearing by rescuing the mutant phenotype, establishing direct causality.

    Evidence BAC transgene rescue in shaker2 mice with ABR and morphology

    PMID:16580798

    Open questions at the time
    • Mechanism of structural maintenance not resolved
    • Isoform-specific contributions not distinguished
  5. 2007 Medium

    Mapped functional requirements to specific regions—the N-terminal extension and the motor domain—linking domain integrity to hearing.

    Evidence Mutation/linkage analysis of consanguineous families plus molecular modeling of a motor-domain missense variant

    PMID:17546645 PMID:17853461

    Open questions at the time
    • Motor-domain powerstroke effect is computational only
    • No biochemical validation of the predicted defect
  6. 2011 Medium

    Extended Myo15 function beyond the cochlea by tying a MyTH4-domain mutation to retinal degeneration and detecting retinal expression.

    Evidence Mutation identification, retinal in situ/RT-PCR, ERG, and histology in a mutant rat

    PMID:21479269

    Open questions at the time
    • Retinal molecular role undefined
    • No partner or cargo identified in retina
  7. 2016 High

    Resolved that distinct isoform classes drive two separable processes—stereocilia development versus long-term maintenance—reconciling variable patient phenotypes with genotype.

    Evidence Synthesis of domain-specific mouse models and human genotype-phenotype correlations; CRISPR-corrected patient iPSC hair cell-like cells

    PMID:26915297 PMID:27375115

    Open questions at the time
    • Molecular trigger for the developmental-to-maintenance switch not defined
    • iPSC model is not native cochlear tissue
  8. 2021 High

    Provided the biochemical basis of motor function and cargo organization: characterized the ATPase cycle as suited to processive oligomeric motility, and showed the Whirlin–Myo15–Eps8 complex phase-separates to bundle actin.

    Evidence Recombinant motor-domain transient kinetics; in vitro ternary-complex reconstitution, phase-separation and actin-bundling assays with deafness-variant mutagenesis

    PMID:33372036 PMID:33626355

    Open questions at the time
    • Oligomerization state in vivo not directly shown
    • Link between motor kinetics and condensate delivery not directly tested in cells
  9. 2021 Medium

    Showed a synonymous splice-altering variant produces a milder progressive phenotype, distinguishing splicing defects from biallelic loss-of-function in pathogenesis.

    Evidence Mini-gene splicing assay and co-segregation across 10 families

    PMID:33398081

    Open questions at the time
    • Residual protein function from aberrant splicing not quantified
  10. 2024 High

    Identified an isoform handoff in which a postnatal isoform sustains elongation-complex delivery and adult stereocilia maintenance, and tied MYO15A isoforms to mechanotransduction-dependent cytoskeletal remodeling.

    Evidence Isoform cloning/expression profiling, conditional mutant mice with stereocilia morphology and EC localization; EM with MET blockade in isoform-specific mutants (both preprint)

    PMID:40027801 PMID:bio_10.1101_2024.09.04.611210

    Open questions at the time
    • Preprint, single-lab data
    • Mechanism coordinating MET signaling with isoform activity unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How motor kinetics, isoform switching, and phase-separated complex delivery are integrated in vivo to specify stereocilia length and maintenance remains unresolved.
  • No in vivo demonstration of motor oligomerization driving condensate transport
  • Retinal mechanism uncharacterized
  • WHRN–MYO15A interface disruption tested only computationally

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003774 cytoskeletal motor activity 2 GO:0008092 cytoskeletal protein binding 2 GO:0016787 hydrolase activity 1 GO:0140657 ATP-dependent activity 1
Localization
GO:0005856 cytoskeleton 3 GO:0005829 cytosol 1
Pathway
R-HSA-1266738 Developmental Biology 2 R-HSA-1643685 Disease 2 R-HSA-9709957 Sensory Perception 2
Partners
EPS8WHRN
Complex memberships
Whirlin–Myosin 15–Eps8 tip complex (elongation-promoting complex)

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 MYO15 (MYO15A) encodes an unconventional myosin protein; missense and nonsense mutations in MYO15 co-segregate with congenital recessive deafness DFNB3, establishing it as the causative gene for this hereditary hearing loss. Positional cloning, sequence analysis of exons in affected individuals from three unrelated DFNB3 families Science High 9603736
1999 Full-length myosin XV (MYO15A) transcripts contain 66 exons encoding a ~365 kDa protein with a unique ~1200-aa N-terminal extension preceding the conserved motor domain; the tail region contains two MyTH4 domains, two FERM-like domains, and a putative SH3 domain. Immunostaining of adult mouse organ of Corti showed that myosin XV protein is concentrated within the cuticular plate and stereocilia of cochlear sensory hair cells. cDNA analysis, genomic sequence comparison, Northern/dot blot, in situ hybridization, immunostaining Genomics High 10552926
2003 Genetic epistasis analysis using double-mutant mice showed that Myo15 function is distinct from Myo6, Myo7a, and the pirouette gene in cochlear stereocilia development; double mutants exhibited superimposition of single-mutant stereocilia phenotypes rather than synergistic or suppressed phenotypes, indicating these myosins act in independent pathways. Genetic epistasis (double-mutant mouse crosses), hearing assessment, cochlear morphology analysis Human molecular genetics High 12966030
2006 BAC transgene containing Myo15a corrects hearing function and cochlear morphology in shaker2 (sh2/sh2) mice for up to 6 months, demonstrating that Myo15a is necessary and sufficient to maintain normal stereocilia structure and hearing; excess Myo15a expression had no deleterious effects on hearing in normal mice. BAC transgene rescue experiment in Myo15a mutant mice, hearing threshold measurement (ABR), cochlear morphology histology Hearing research High 16580798
2007 Two homozygous truncating mutations in exon 2 of MYO15A (encoding the large N-terminal extension) are associated with severe-to-profound hearing loss, demonstrating that the long isoform containing the ~1200-aa N-terminal extension (isoform 1) is functionally necessary for normal hearing. Mutation analysis of consanguineous families, linkage analysis, DNA sequencing of MYO15A exons Human mutation Medium 17546645
2007 A missense mutation c.5492G>T (p.Gly1831Val) in the MYO15A motor domain disrupts hearing; molecular modeling of the motor head domain predicted that the Gly1831Val mutation inhibits the powerstroke by reducing backbone flexibility and weakening hydrophobic interactions necessary for signal transmission to the converter domain. Genetic linkage analysis, DNA sequencing, 3D molecular modeling of motor head domain American journal of medical genetics. Part A Low 17853461
2011 A missense mutation (T>C, Leu to Pro) in exon 56 of Myo15 within the carboxy-terminal MyTH4 domain in the LEW/Ztm-ci2 rat causes deafness and retinal degeneration (Usher-like syndrome); Myo15 mRNA was detected in the retina by in situ hybridization and PCR, indicating a role beyond the cochlea. Mutation identification by sequencing, in situ hybridization and RT-PCR for retinal expression, electroretinography, histological analysis PloS one Medium 21479269
2016 Two distinct MYO15A isoform classes exist: isoform 1 (with exon 2-encoded N-terminal extension) is required for stereocilia development, while loss of this N-terminal extension causes a milder hearing loss phenotype. Studies in Myo15 mouse models revealed two distinct pathogenic mechanisms: myosin 15 is required both for development and for long-term maintenance of stereocilia. Analysis of mouse models with domain-specific mutations, review of mutational data from human patients with domain-specific genotype-phenotype correlations Human mutation High 27375115
2021 The Whirlin–Myosin 15 (Myo15)–Eps8 complex forms tip complex density (TCD)-like condensates through liquid-liquid phase separation driven by specific multivalent interactions among complex components. The reconstituted TCD-like condensates promote actin bundling. A deafness-associated mutation of Myo15 interfered with condensate formation and consequently impaired actin bundling. Protein reconstitution in vitro, phase separation assays, actin bundling assays, mutagenesis of deafness-associated Myo15 variant Cell reports High 33626355
2021 The MYO15 motor domain has a moderate duty ratio (~0.5), weak thermodynamic coupling between ADP and actin binding, and ADP release from the actin-attached state is the slowest measured transition (~12 s⁻¹ at 20°C). The kinetic profile is consistent with MYO15 being adapted for processive motility when oligomerized. The ATPase cycle was characterized with major rate constants for ATP/ADP/actin binding, hydrolysis, and phosphate release. Recombinant minimal motor domain (S1) purification using baculovirus-Sf9 system, stopped-flow and quenched-flow transient kinetic analyses, actin-activated ATPase assay The Journal of biological chemistry High 33372036
2021 A synonymous variant c.9861 C>T in MYO15A causes abnormal splicing confirmed by mini-gene assay, leading to progressive post-lingual hearing loss distinct from the congenital profound deafness caused by biallelic loss-of-function variants. Mini-gene splicing assay, co-segregation analysis in 10 unrelated families, biallelic variant confirmation European journal of human genetics Medium 33398081
2024 A new MYO15A isoform (MYO15A-3) is expressed in postnatal hair cells as MYO15A-2 wanes. MYO15A-2 initially delivers the elongation-promoting complex (EC) to stereocilia tips; postnatally, MYO15A-3 takes over EC delivery. In Myo15a-3 mutant mice, stereocilia develop normally with correct initial EC targeting but lack the EC postnatally and fail to maintain adult stereocilia architecture, causing progressive hearing loss. Characterization of new isoform by molecular cloning, conditional mutant mouse (Myo15a-3 mutant) with stereocilia morphology analysis, expression profiling, EC complex localization by immunofluorescence bioRxivpreprint High 40027801
2024 MYO15A isoforms are required for mechanotransduction (MET)-dependent remodeling of the actin cytoskeleton in auditory stereocilia. Hair cells lacking all functional MYO15A isoforms did not exhibit MET-dependent stereocilia cytoskeletal remodeling. Hair cells lacking only the long isoform (MYO15A-1) showed increased MET-dependent remodeling including in non-transducing stereocilia rows, indicating that MYO15A-1 fine-tunes this process. Electron microscopy of cochlear explants, pharmacological blockade of MET currents, isoform-specific MYO15A mutant mice bioRxivpreprint Medium bio_10.1101_2024.09.04.611210
2016 iPSC-derived hair cell-like cells from patients carrying compound heterozygous MYO15A mutations (c.4642G>A and c.8374G>A) showed abnormal morphology and dysfunction compared to controls. CRISPR/Cas9 genetic correction of the MYO15A mutation in iPSCs rescued morphology and function of derived hair cell-like cells, demonstrating that the MYO15A mutations directly cause hair cell dysfunction. iPSC generation from patients, hair cell differentiation, CRISPR/Cas9 gene correction, morphological and functional analysis of derived hair cell-like cells Cell death and differentiation Medium 26915297
2024 A novel MYO15A variant (c.2482C>T) located in the N-terminal domain caused significant differences in morphology and function of iPSC-derived hair cell-like cells compared to controls, without affecting iPSC totipotency, demonstrating that N-terminal domain integrity is required for normal hair cell function. iPSC generation from proband, hair cell differentiation, morphological and functional comparison between mutant and control iPSC-derived hair cell-like cells Molecular genetics & genomic medicine Low 39620501
2025 Computational analysis predicted that missense SNPs in WHRN destabilize the WHRN–MYO15A protein-protein complex, with molecular docking and dynamics showing altered binding affinity and stability of the complex; however, this is computational only. In silico SNP pathogenicity prediction, molecular docking (Haddock), molecular dynamics simulation, binding energy calculation (PRODIGY) Journal of biomolecular structure & dynamics Low 40389825

Source papers

Stage 0 corpus · 68 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3. Science (New York, N.Y.) 353 9603736
1995 A gene for congenital, recessive deafness DFNB3 maps to the pericentromeric region of chromosome 17. Nature genetics 186 7704031
1999 Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2. Genomics 137 10552926
2001 Novel mutations of MYO15A associated with profound deafness in consanguineous families and moderately severe hearing loss in a patient with Smith-Magenis syndrome. Human genetics 96 11735029
2016 Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation. Cell death and differentiation 78 26915297
2016 Mutational Spectrum of MYO15A and the Molecular Mechanisms of DFNB3 Human Deafness. Human mutation 72 27375115
2007 Mutational spectrum of MYO15A: the large N-terminal extension of myosin XVA is required for hearing. Human mutation 72 17546645
2012 Screening for MYO15A gene mutations in autosomal recessive nonsyndromic, GJB2 negative Iranian deaf population. American journal of medical genetics. Part A 47 22736430
1998 Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2. American journal of human genetics 43 9529344
2015 Mutations in the MYO15A gene are a significant cause of nonsyndromic hearing loss: massively parallel DNA sequencing-based analysis. The Annals of otology, rhinology, and laryngology 42 25792667
2010 Recurrent and private MYO15A mutations are associated with deafness in the Turkish population. Genetic testing and molecular biomarkers 40 20642360
2009 Mutations in the first MyTH4 domain of MYO15A are a common cause of DFNB3 hearing loss. The Laryngoscope 40 19274735
2007 MYO15A (DFNB3) mutations in Turkish hearing loss families and functional modeling of a novel motor domain mutation. American journal of medical genetics. Part A 39 17853461
2019 Genotype-phenotype correlation analysis of MYO15A variants in autosomal recessive non-syndromic hearing loss. BMC medical genetics 38 30953472
2009 Screening of the DFNB3 locus: identification of three novel mutations of MYO15A associated with hearing loss and further suggestion for two distinctive genes on this locus. Genetic testing and molecular biomarkers 35 19309289
2013 Whole-exome sequencing identifies MYO15A mutations as a cause of autosomal recessive nonsyndromic hearing loss in Korean families. BMC medical genetics 33 23865914
2011 Prioritized sequencing of the second exon of MYO15A reveals a new mutation segregating in a Pakistani family with moderate to severe hearing loss. European journal of medical genetics 33 22245518
2003 Myo15 function is distinct from Myo6, Myo7a and pirouette genes in development of cochlear stereocilia. Human molecular genetics 30 12966030
2024 Hair cell-specific Myo15 promoter-mediated gene therapy rescues hearing in DFNB9 mouse model. Molecular therapy. Nucleic acids 28 38404504
2015 Identification of a Novel MYO15A Mutation in a Chinese Family with Autosomal Recessive Nonsyndromic Hearing Loss. PloS one 28 26308726
2015 Identification and Clinical Implications of Novel MYO15A Mutations in a Non-consanguineous Korean Family by Targeted Exome Sequencing. Molecules and cells 27 26242193
2021 Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex. Cell reports 26 33626355
2013 Novel compound heterozygous mutations in the MYO15A gene in autosomal recessive hearing loss identified by whole-exome sequencing. Journal of translational medicine 23 24206587
2022 Exosomal microRNA-1 and MYO15A as a target for therapy and diagnosis in renal cell carcinoma. Biochemical and biophysical research communications 22 36150242
2017 MYO15A splicing mutations in hearing loss: A review literature and report of a novel mutation. International journal of pediatric otorhinolaryngology 20 28390610
2016 A novel founder MYO15A frameshift duplication is the major cause of genetic hearing loss in Oman. Journal of human genetics 19 27734841
2016 Targeted Resequencing of Deafness Genes Reveals a Founder MYO15A Variant in Northeastern Brazil. Annals of human genetics 19 27870113
2002 DFNB3, spectrum of MYO15A recessive mutant alleles and an emerging genotype-phenotype correlation. Advances in oto-rhino-laryngology 18 12408074
2017 Homozygous mutations in PJVK and MYO15A genes associated with non-syndromic hearing loss in Moroccan families. International journal of pediatric otorhinolaryngology 17 28964305
2024 Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear. Research (Washington, D.C.) 16 38665848
2019 Identification and Clinical Implications of a Novel MYO15A Variant in a Consanguineous Iranian Family by Targeted Exome Sequencing. Audiology & neuro-otology 16 30943474
2021 The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness. The Journal of biological chemistry 15 33372036
2019 Identification of novel variants in MYO15A, OTOF, and RDX with hearing loss by next-generation sequencing. Molecular genetics & genomic medicine 14 31250571
2015 A novel recessive truncating mutation in MYO15A causing prelingual sensorineural hearing loss. International journal of pediatric otorhinolaryngology 14 26810297
2021 A synonymous variant in MYO15A enriched in the Ashkenazi Jewish population causes autosomal recessive hearing loss due to abnormal splicing. European journal of human genetics : EJHG 13 33398081
2021 Identification of Hearing Loss-Associated Variants of PTPRQ, MYO15A, and SERPINB6 in Pakistani Families. BioMed research international 13 33997018
2020 The worldwide frequency of MYO15A gene mutations in patients with non-syndromic hearing loss: A meta-analysis. Iranian journal of basic medical sciences 13 32774803
2018 Three MYO15A Mutations Identified in One Chinese Family with Autosomal Recessive Nonsyndromic Hearing Loss. Neural plasticity 12 29849560
2006 Transgene correction maintains normal cochlear structure and function in 6-month-old Myo15a mutant mice. Hearing research 12 16580798
2021 Whole exome sequencing reveals pathogenic variants in MYO3A, MYO15A and COL9A3 and differential frequencies in ancestral alleles in hearing impairment genes among individuals from Cameroon. Human molecular genetics 11 33078831
2003 The circling behavior of the deafblind LEW-ci2 rat is linked to a segment of RNO10 containing Myo15 and Kcnj12. Mammalian genome : official journal of the International Mammalian Genome Society 10 14629112
2023 Loss-of-function mutations in MYO15A and OTOF cause non-syndromic hearing loss in two Yemeni families. Human genomics 9 37189200
2020 Whole exome sequencing identifies novel compound heterozygous pathogenic variants in the MYO15A gene leading to autosomal recessive non-syndromic hearing loss. Molecular biology reports 9 32623615
2016 Screening of DFNB3 in Iranian families with autosomal recessive non-syndromic hearing loss reveals a novel pathogenic mutation in the MyTh4 domain of the MYO15A gene in a linked family. Iranian journal of basic medical sciences 9 27635202
2020 Targeted Next-Generation Sequencing Identified Compound Heterozygous Mutations in MYO15A as the Probable Cause of Nonsyndromic Deafness in a Chinese Han Family. Neural plasticity 6 32617096
2018 A novel nonsense mutation in MYO15A is associated with non-syndromic hearing loss: a case report. BMC medical genetics 6 30068307
2016 Genetic Linkage Analysis of DFNB3, DFNB9 and DFNB21 Loci in GJB2 Negative Families with Autosomal Recessive Non-syndromic Hearing Loss. Iranian journal of public health 6 27398341
2002 Cloning and chromosomal localization of MYO15A to chromosome 5 of the dog (Canis familiaris). Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 6 12296523
2022 Analysis of the genotype-phenotype correlation of MYO15A variants in Chinese non-syndromic hearing loss patients. BMC medical genomics 5 35346193
2021 Hearing Features and Cochlear Implantation Outcomes in Patients With Pathogenic MYO15A Variants: a Multicenter Observational Study. Ear and hearing 5 34974475
2011 A mutation in Myo15 leads to Usher-like symptoms in LEW/Ztm-ci2 rats. PloS one 5 21479269
2020 Post-lingual non-syndromic hearing loss phenotype: a polygenic case with 2 biallelic mutations in MYO15A and MITF. BMC medical genetics 4 31898538
2019 Identification of a novel homozygous mutation in the MYO15A gene in a Kazakh family with non-syndromic hearing loss. International journal of pediatric otorhinolaryngology 4 31301639
2019 Report of a Novel Splicing Mutation in the MYO15A Gene in a Patient With Sensorineural Hearing Loss and Spectrum of the MYO15A Mutations. Clinical medicine insights. Case reports 4 31579092
2021 Identification of Novel and Recurrent Variants in MYO15A in Ashkenazi Jewish Patients With Autosomal Recessive Nonsyndromic Hearing Loss. Frontiers in genetics 3 34733312
2020 Investigation of MYO15A and MYO7A Mutations in Iranian Patients with Nonsyndromic Hearing Loss. Fetal and pediatric pathology 3 31997689
2020 Compound Heterozygous Mutations in TMC1 and MYO15A Are Associated with Autosomal Recessive Nonsyndromic Hearing Loss in Two Chinese Han Families. Neural plasticity 3 32802042
2025 Computational study of the potential impact of WHRN protein missense SNPs on WHRN-MYO15A protein complex interaction and their association with Usher syndrome. Journal of biomolecular structure & dynamics 2 40389825
2024 Novel compound heterozygous MYO15A splicing variants in autosomal recessive non-syndromic hearing loss. BMC medical genomics 2 38167320
2022 Identification of novel compound heterozygous mutations of the MYO15A gene with autosomal recessive non-syndromic hearing loss. Journal of clinical laboratory analysis 2 36217262
2021 Identification of Novel Compound Heterozygous MYO15A Mutations in Two Chinese Families with Autosomal Recessive Nonsyndromic Hearing Loss. Neural plasticity 2 34093702
2020 [Analysis of MYO15A variation in children with DFNB3]. Zhonghua er ke za zhi = Chinese journal of pediatrics 2 32987461
2013 Linkage study of DFNB3 responsible for hearing loss in human. Indian journal of human genetics 2 24339546
2025 A Myosin Nanomotor Essential for Stereocilia Maintenance Expands the Etiology of Hereditary Hearing Loss DFNB3. bioRxiv : the preprint server for biology 1 40027801
2025 The clinical and genetic spectrum of twenty-six individuals with hearing loss affected by MYO15A variants. Scientific reports 1 40275102
2024 A Novel Mutation Located in the N-Terminal Domain of MYO15A Caused Sensorineural Hearing Loss. Molecular genetics & genomic medicine 1 39620501
2024 A Novel Deleterious MYO15A Gene Mutation Causes Nonsyndromic Hearing Loss. Iranian journal of otorhinolaryngology 0 38259694
2024 [Genetic and phenotypic analysis of MYO15A rare variants associated with autosomal recessive hearing loss]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery 0 38297847

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