Affinage

MYBL1

Myb-related protein A · UniProt P10243

Length
752 aa
Mass
85.9 kDa
Annotated
2026-06-10
100 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MYBL1 (A-MYB) is a nuclear sequence-specific transcriptional activator that binds the classical Myb recognition element (PyAACG/TG, preferring TAACGG) through its N-terminal three-repeat DNA-binding domain and activates target transcription far more strongly than c-Myb (PMID:8058310). Transactivation depends on an acidic activation domain mapping to residues 218–319, which physically recruits the coactivator CBP/p300; a downstream segment inhibits DNA binding and the C-terminal ~110 residues constitute a negative-regulatory domain that dampens maximal activity (PMID:9210395). A-MYB activity is gated by the cell cycle and signaling: cyclin A/E–associated CDK phosphorylation of the C-terminal domain relieves its autoinhibition to peak activity at G1/S (PMID:9285555), while the Wnt-NLK pathway phosphorylates A-MYB to disrupt its CBP interaction and promote H3K9 methylation at bound promoters (PMID:16055500). In male meiosis, A-MYB is an essential master regulator that appears specifically in pachytene spermatocytes and directs a program of meiotic genes—including the direct target RFX2—such that its loss causes pachytene arrest, defective synapsis, incomplete DSB repair, and absence of crossovers (PMID:9109487, PMID:20003220, PMID:21750041); mechanistically it cooperates with BRDT to release paused RNA Pol II and drive a late-prophase transcriptional burst (PMID:36990976). Deletion of the C-terminal negative-regulatory domain converts MYBL1 into a constitutively active oncogene: C-terminally truncated forms arising from duplication or recurrent fusions (MYBL1-NFIB, MYBL1-RAD51B) drive transformation in pediatric low-grade glioma and adenoid cystic carcinoma (PMID:23633565, PMID:26631070, PMID:26631609), and in hepatocellular carcinoma MYBL1 directly transactivates ANGPT2 to promote angiogenesis in a PRMT5/MEP50/WDR5-dependent manner (PMID:35987690).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1988 Medium

    Establishing the primary structure of human A-myb identified it as a c-myb-related gene, raising the question of whether it functions as a transcription factor.

    Evidence cDNA library screening and sequence analysis revealing three conserved Myb-homology domains

    PMID:3060855

    Open questions at the time
    • No functional or DNA-binding assay
    • Tissue and cell-cycle context unknown
  2. 1994 High

    Demonstrating that A-MYB is a nuclear activator binding the Myb consensus site answered whether the protein is functionally a transcription factor and showed it is a stronger activator than c-Myb.

    Evidence Gel retardation, DNase I footprinting, reporter cotransfection and deletion mutagenesis in NIH3T3 cells; orthologous activation assays in mouse and chicken with expression profiling

    PMID:7813437 PMID:8058310 PMID:8058311 PMID:8084617

    Open questions at the time
    • Coactivators and partner proteins not identified
    • In vivo target genes unknown
    • Regulation of activity not defined
  3. 1995 Medium

    Mapping negative regulatory domains established that A-Myb activity is intrinsically autoinhibited, framing later work on how this restraint is relieved or lost.

    Evidence Deletion mutagenesis and reporter cotransfection

    PMID:7821437

    Open questions at the time
    • Molecular signals controlling the negative domains unresolved
    • No structural detail
  4. 1997 High

    Defining the transactivation domain and its physical recruitment of CBP/p300, together with CDK-mediated relief of C-terminal autoinhibition, answered how A-Myb activates transcription and how its activity is timed to G1/S.

    Evidence Deletion mapping, CBP co-immunoprecipitation/binding, in vitro cyclin A/E kinase assays, cell-cycle synchronization; microinjection/BrdU cooperation with c-myc in smooth muscle cells

    PMID:9111313 PMID:9210395 PMID:9285555

    Open questions at the time
    • Specific CDK responsible not pinpointed
    • Phosphosite-level mapping incomplete
  5. 1997 High

    Germline knockout established the physiological necessity of A-myb, revealing essential and non-redundant roles in pachytene-stage spermatogenesis and mammary development.

    Evidence Gene-targeted knockout mice with histological analysis of testes and mammary glands; B-cell and tissue expression profiling

    PMID:9109487 PMID:9510180

    Open questions at the time
    • Direct meiotic target genes not yet identified
    • Mechanism of pachytene arrest unresolved
  6. 2000 Medium

    Identifying A-Myb cooperation with Cdx2 on the bcl-2 promoter probed how A-Myb can regulate genes beyond canonical Myb sites, via partner homeodomain factors.

    Evidence Promoter deletion, UV cross-linking, Cdx2 co-immunoprecipitation, mutagenesis and reporter assays in follicular lymphoma cells

    PMID:10692454

    Open questions at the time
    • Direct A-Myb DNA binding to the Cdx site could not be demonstrated
    • Physiological relevance in B-cell biology unconfirmed
  7. 2005 High

    Showing that Wnt-NLK signaling inhibits A-Myb by disrupting CBP binding and inducing repressive H3K9 methylation answered how A-Myb is negatively regulated by extracellular signaling distinct from c-Myb degradation.

    Evidence Co-IP, in vitro kinase assay, reporter assays, and ChIP for H3K9 methylation

    PMID:16055500

    Open questions at the time
    • NLK phosphosites on A-Myb not mapped
    • Histone methyltransferase recruited not identified
  8. 2011 High

    Genome-wide target mapping and a separation-of-function allele established MYBL1 as a male-specific master regulator of meiotic progression, defining direct targets including RFX2 and linking loss to synapsis, DSB repair and crossover failure.

    Evidence ENU separation-of-function allele, meiotic cytology, ChIP-chip and expression profiling; ChIP, gel shift, reporter and knockout validation of the Rfx2 target

    PMID:20003220 PMID:21750041

    Open questions at the time
    • Full direct target network incompletely defined
    • Mechanism coupling transcription to recombination unresolved
  9. 2013 High

    Functional assays of C-terminally truncated MYBL1 established that loss of the negative-regulatory domain produces an oncogenic gain-of-function form, connecting domain architecture to tumorigenesis.

    Evidence Whole-genome sequencing of pediatric low-grade gliomas with anchorage-independent growth and nude-mouse xenograft assays of truncated constructs

    PMID:23633565

    Open questions at the time
    • Downstream oncogenic target genes in glioma not defined
    • Mechanism of transformation beyond derepression unknown
  10. 2015 Medium

    Discovery of recurrent MYBL1-NFIB and MYBL1-RAD51B fusions in adenoid cystic carcinoma established MYBL1 as an interchangeable oncogenic driver with MYB, all alterations converging on C-terminal domain deletion.

    Evidence RNA-seq and whole-genome sequencing fusion detection plus expression profiling across cohorts

    PMID:26631070 PMID:26631609

    Open questions at the time
    • No functional rescue of the specific fusions
    • Fusion partner contributions not dissected
  11. 2022 Medium

    Identifying ANGPT2 as a direct MYBL1 target dependent on PRMT5/MEP50/WDR5 revealed a pro-angiogenic transcriptional axis in hepatocellular carcinoma linked to sorafenib resistance.

    Evidence ChIP, reporter assays, overexpression/knockdown angiogenesis assays and xenografts, with co-IP of PRMT5/MEP50/WDR5

    PMID:35987690

    Open questions at the time
    • Cofactor requirement rests on Co-IP without full reconstitution
    • Direct biochemical role of each cofactor undefined
  12. 2023 High

    Mapping A-MYB cooperation with BRDT in releasing paused Pol II answered how A-MYB drives the late-prophase transcriptional burst and showed transcription is temporally segregated from recombination.

    Evidence ATAC-seq, nascent transcription assays, mRNA-seq and genome-wide Pol II occupancy mapping in spermatocytes

    PMID:36990976

    Open questions at the time
    • Direct A-MYB–BRDT physical interaction not detailed
    • How shared chromatin marks are temporally decoded unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the same MYBL1 transcriptional output is differentially deployed across meiosis, B-cell/mammary development, and oncogenic contexts—and which cofactors and chromatin states specify each program—remains unresolved.
  • Context-specific cofactor codes not defined
  • Structural basis of C-terminal autoinhibition unknown
  • Full direct target catalog across tissues incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 5 GO:0003677 DNA binding 2
Localization
GO:0005634 nucleus 1
Pathway
R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1474165 Reproduction 3 R-HSA-1643685 Disease 3 R-HSA-1640170 Cell Cycle 2
Partners
BRDTCDX2CREBBPEP300HIPK2NLKPRMT5WDR5

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1988 Human MYBL1 (A-myb) cDNA was isolated and sequenced, revealing a predicted protein of ~745 amino acids with three conserved domains (I, II, III) homologous to the c-myb DNA-binding domain; mRNA was ~5.0 kb. cDNA library screening, sequence analysis Nucleic acids research Medium 3060855
1994 Human A-MYB protein is a nuclear transcriptional activator ~90 kDa in size; it binds the classical c-myb recognition sequence PyAACG/TG (specifically preferring TAACGG over TAAGTG) and activates transcription 6–10-fold more strongly than c-myb in NIH3T3 cells. Transactivation requires both the DNA-binding domain and an acidic domain; DNA-binding requires the N-terminal three-repeat region. Reporter gene cotransfection, gel retardation assay, DNase I footprinting, Western blot, deletion mutagenesis Oncogene High 8058310
1994 Mouse A-myb encodes a transcriptional activator with properties similar to c-myb and v-myb proteins; during embryogenesis it is expressed in proliferating neuronal precursor cells, and in adult mice it is expressed during early spermatogenesis and in germinal-center B lymphocytes. Reporter gene transactivation assays, Northern blot, in situ hybridization, chromosome mapping The EMBO journal Medium 7813437
1994 Chicken A-myb encodes a transcriptional activator that transactivates myb-responsive reporter genes and activates myb-inducible endogenous genes when stably expressed in macrophage cell line; expressed in fibroblasts unlike c-myb. Reporter gene transactivation, stable expression in macrophage cell line, Northern blot Oncogene Medium 8058311
1994 Murine A-myb exhibits differential splicing producing alternatively spliced mRNAs encoding smaller proteins; expression is highest in type A spermatogonia and pachytene spermatocytes, with down-regulation upon terminal differentiation to mature spermatozoa. Northern blot, in situ hybridization, cDNA sequence analysis Oncogene Medium 8084617
1995 Human A-Myb contains two negative regulatory domains in addition to a DNA-binding domain and a transactivation domain; these negative regulatory domains dampen transactivation activity, and A-Myb functions predominantly in testis and peripheral blood leukocytes. Deletion mutagenesis, reporter gene cotransfection FEBS letters Medium 7821437
1997 The transactivation domain of A-Myb maps to residues 218–319 (centred on a charged region 259–281); a region immediately downstream (320–482) inhibits DNA binding; the C-terminal ~110 residues (643–752) negatively regulate maximal transactivation. A-Myb physically interacts with the coactivator CBP (and its homologue p300) through the charged region, and CBP synergizes with A-Myb in a dose-dependent, E1A-inhibitable manner. Deletion mutagenesis, reporter gene cotransfection, co-immunoprecipitation / binding assay with CBP The Biochemical journal High 9210395
1997 The C-terminal regulatory domain of A-Myb is phosphorylated by cyclin A– and cyclin E–associated kinases, which relieves C-terminal inhibition and increases transactivation potential; A-myb mRNA peaks at the late G1/early S-phase transition, suggesting A-Myb activity is controlled by two mechanisms (transcription and CDK phosphorylation) to peak at G1/S. In vitro kinase assay, reporter gene cotransfection with cyclin expression vectors, cell cycle synchronization, Northern blot Oncogene High 9285555
1997 A-myb is expressed in bovine aortic smooth muscle cells in a cell cycle-dependent manner (peaks at late G1/S); it strongly transactivates MBS-containing reporters (~30-fold) and the c-myc promoter (~50-fold); co-microinjection of A-myb with c-myc synergistically drives quiescent SMCs into S phase, demonstrating cooperation with c-myc in cell cycle progression. Northern blot, nuclear run-on, reporter gene transfection, microinjection into quiescent cells with BrdU labeling Molecular and cellular biology High 9111313
1997 Mice homozygous for a germline A-myb null mutation develop normally to term but display: (1) male infertility due to spermatogenic arrest at the pachytene stage of meiotic prophase, and (2) female breast epithelial underdevelopment with failure to nurse pups. These phenotypes establish essential roles for A-myb in spermatogenesis and mammary gland development. Gene targeting/knockout mouse, morphological and histological analysis of testes and mammary glands Nature High 9109487
1997 A-Myb expression in human tonsillar B cells is restricted to the dark zone (centroblasts), is cell cycle-regulated (detectable only in S and G2/M phases, absent in G0/G1), and is not induced by diverse in vitro polyclonal activators that otherwise drive B-cell proliferation, indicating A-Myb marks a specific in vivo centroblast state rather than proliferation per se. In situ hybridization, FACS cell cycle analysis, in vitro stimulation experiments Journal of immunology Medium 9510180
2000 A-Myb up-regulates bcl-2 promoter activity in t(14;18) follicular lymphoma cells through a Cdx homeodomain protein binding site; A-Myb co-purifies with Cdx2 on the Cdx binding sequence, but direct Myb binding to this sequence could not be demonstrated; mutation of the Cdx site abolishes A-Myb-responsive up-regulation. Co-transfection of A-Myb and Cdx2 strongly synergizes in activating the bcl-2 P2 promoter. Promoter deletion analysis, UV cross-linking, co-immunoprecipitation with Cdx2, reporter gene assay, mutagenesis, Western blot The Journal of biological chemistry Medium 10692454
2004 Vertebrate B-Myb but not A-Myb or c-Myb can complement loss of Drosophila Myb in hemocyte proliferation; A-Myb and c-Myb cause lethality in Drosophila, indicating A-Myb has acquired neomorphic functions distinct from the ancestral proliferative Myb function shared by B-Myb and Dm-Myb. Genetic complementation in Drosophila (transgenic rescue), hemocyte proliferation assay Genetics Medium 15489525
2005 The Wnt-NLK signaling pathway inhibits A-Myb transcriptional activity by a mechanism distinct from c-Myb: NLK and HIPK2 bind directly to A-Myb and NLK phosphorylates A-Myb, but unlike c-Myb, A-Myb is not degraded. Instead, NLK phosphorylation disrupts the interaction between A-Myb and its coactivator CBP, blocking transactivation; furthermore, NLK induces methylation of histone H3 at lysine-9 at A-Myb-bound promoter regions. Co-immunoprecipitation, reporter gene assay, in vitro kinase assay, chromatin immunoprecipitation (ChIP) for H3K9 methylation Molecular biology of the cell High 16055500
2009 RFX2 is a downstream target of A-MYB in pachytene spermatocytes: A-MYB binds MYB-binding sites in the Rfx2 promoter in vivo (ChIP), activates Rfx2 promoter in transfected cells, and Rfx2 expression is virtually eliminated in A-myb knockout testes. A-MYB expression is up-regulated specifically in pachytene spermatocytes, preceding RFX2 induction. Chromatin immunoprecipitation (ChIP), electrophoretic gel shift, co-transfection reporter assay, A-myb knockout analysis, immunohistology BMC developmental biology High 20003220
2011 MYBL1 is a male-specific master regulator of meiosis in spermatocytes: a separation-of-function allele (Mybl1repro9) causes defects in autosome synapsis at pachynema, unsynapsed sex chromosomes, incomplete DSB repair, and absence of crossovers. ChIP-chip and promoter bioinformatic analysis identified direct MYBL1 target genes involved in multiple meiotic processes including cell cycle progression through pachynema; MYBL1 protein appears specifically in pachynema. Genetic screen (ENU mutagenesis), histological/cytological analysis of meiosis, ChIP-chip, gene expression profiling, bioinformatic promoter analysis Development High 21750041
2013 Truncated MYBL1 transcripts (lacking the C-terminal negative-regulatory domain), generated by 8q13.1 partial duplication in diffuse pediatric low-grade gliomas, induce anchorage-independent growth in 3T3 cells and tumor formation in nude mice, establishing oncogenic gain-of-function activity of C-terminally truncated MYBL1. Whole-genome sequencing, copy-number analysis, functional assay (anchorage-independent growth in 3T3 cells, nude mouse xenograft) Proceedings of the National Academy of Sciences High 23633565
2015 Novel t(8;9) and t(8;14) translocations fuse MYBL1 to NFIB and RAD51B, respectively, in adenoid cystic carcinoma (ACC) lacking MYB-NFIB. All MYBL1 alterations involve deletion of the C-terminal negative regulatory domain and correlate with high MYBL1 expression; MYB and MYBL1 translocations produce similar gene expression profiles, suggesting interchangeable oncogenic driver roles. RNA sequencing of archival FFPE samples, fusion transcript detection, gene expression profiling Cancer discovery Medium 26631070
2015 Multiple MYBL1 rearrangements in ACC consistently involve deletion of the C-terminal negative regulatory domain and are associated with high MYBL1 expression; reciprocal and mutually exclusive expression of MYB and MYBL1 is a consistent feature; distinct gene expression profiles are associated with length of MYB/MYBL1 fusions, indicating biological importance of the C-terminal domain. Whole-genome sequencing, targeted molecular analysis, microarray gene-expression profiling, FISH Clinical cancer research Medium 26631609
2022 MYBL1 binds directly to the ANGPT2 promoter and transcriptionally upregulates ANGPT2 mRNA, promoting tumor angiogenesis in hepatocellular carcinoma; PRMT5, MEP50, and WDR5 (histone post-translational modification factors) are required for MYBL1-mediated ANGPT2 upregulation. MYBL1-overexpressing HCC cells show increased sorafenib resistance reversed by anti-ANGPT2 antibody. Chromatin immunoprecipitation (ChIP), reporter gene assay, overexpression/knockdown functional assays (tube formation, HUVEC migration, CAM neovascularization, xenograft), Western blot, co-immunoprecipitation with PRMT5/MEP50/WDR5 Cell death & disease Medium 35987690
2023 In mammalian meiosis, A-MYB (MYBL1) and BRDT cooperate to release paused RNA Polymerase II during late prophase I of spermatogenesis, orchestrating a ~3-fold transcriptional burst; A-MYB-dependent transcriptional activation is temporally segregated from meiotic recombination despite shared chromatin marks. ATAC-seq (chromatin accessibility), nascent transcription assay (GRO-seq or equivalent), processed mRNA sequencing, genome-wide Pol II occupancy mapping Nature communications High 36990976

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Light-induced expression of a MYB gene regulates anthocyanin biosynthesis in red apples. Plant physiology 634 17012405
1997 Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 441 9034194
2007 Isolation and functional analysis of a MYB transcription factor gene that is a key regulator for the development of red coloration in apple skin. Plant & cell physiology 379 17526919
1995 Gibberellin-regulated expression of a myb gene in barley aleurone cells: evidence for Myb transactivation of a high-pI alpha-amylase gene promoter. The Plant cell 362 8535141
1998 The PHANTASTICA gene encodes a MYB transcription factor involved in growth and dorsoventrality of lateral organs in Antirrhinum. Cell 349 9630222
2005 LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms. Proceedings of the National Academy of Sciences of the United States of America 326 16006522
1994 Flower colour intensity depends on specialized cell shape controlled by a Myb-related transcription factor. Nature 274 8208293
1988 Isolation of human cDNA clones of myb-related genes, A-myb and B-myb. Nucleic acids research 247 3060855
1999 ROUGH SHEATH2: a Myb protein that represses knox homeobox genes in maize lateral organ primordia. Science (New York, N.Y.) 239 10102816
2009 REVEILLE1, a Myb-like transcription factor, integrates the circadian clock and auxin pathways. Proceedings of the National Academy of Sciences of the United States of America 213 19805390
2010 Carbon starved anther encodes a MYB domain protein that regulates sugar partitioning required for rice pollen development. The Plant cell 201 20305120
1996 The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human. Nucleic acids research 199 8614633
2002 The tomato Blind gene encodes a MYB transcription factor that controls the formation of lateral meristems. Proceedings of the National Academy of Sciences of the United States of America 196 11805344
2007 Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. The Journal of cell biology 194 17339379
1997 Arrest of spermatogenesis and defective breast development in mice lacking A-myb. Nature 189 9109487
2015 Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor-Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma. Cancer discovery 184 26631070
1989 BAS1 has a Myb motif and activates HIS4 transcription only in combination with BAS2. Science (New York, N.Y.) 175 2683089
2015 Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations. Clinical cancer research : an official journal of the American Association for Cancer Research 170 26631609
2013 Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proceedings of the National Academy of Sciences of the United States of America 167 23633565
2010 The purple cauliflower arises from activation of a MYB transcription factor. Plant physiology 158 20855520
2019 Overexpression of a MYB Family Gene, OsMYB6, Increases Drought and Salinity Stress Tolerance in Transgenic Rice. Frontiers in plant science 149 30833955
2019 A MYB/bHLH complex regulates tissue-specific anthocyanin biosynthesis in the inner pericarp of red-centered kiwifruit Actinidia chinensis cv. Hongyang. The Plant journal : for cell and molecular biology 149 30912865
2009 DkMyb4 is a Myb transcription factor involved in proanthocyanidin biosynthesis in persimmon fruit. Plant physiology 142 19783643
1992 Expression of the CD4 gene requires a Myb transcription factor. Molecular and cellular biology 136 1347906
2015 Brassinosteroids promote development of rice pollen grains and seeds by triggering expression of Carbon Starved Anther, a MYB domain protein. The Plant journal : for cell and molecular biology 135 25754973
1991 Expression of c-myb and B-myb, but not A-myb, correlates with proliferation in human hematopoietic cells. Blood 132 1984793
1995 flbD encodes a Myb-like DNA-binding protein that coordinates initiation of Aspergillus nidulans conidiophore development. Genes & development 128 7883170
2001 LAF1, a MYB transcription activator for phytochrome A signaling. Genes & development 125 11581165
1994 Mouse A-myb encodes a trans-activator and is expressed in mitotically active cells of the developing central nervous system, adult testis and B lymphocytes. The EMBO journal 107 7813437
2011 A-MYB (MYBL1) transcription factor is a master regulator of male meiosis. Development (Cambridge, England) 106 21750041
2014 Brassinosteroids control root epidermal cell fate via direct regulation of a MYB-bHLH-WD40 complex by GSK3-like kinases. eLife 105 24771765
2019 Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course. Acta neuropathologica 98 31563982
2011 Differential regulation of a MYB transcription factor is correlated with transgenerational epigenetic inheritance of trichome density in Mimulus guttatus. The New phytologist 98 21352232
2011 Identification of genes in the phenylalanine metabolic pathway by ectopic expression of a MYB transcription factor in tomato fruit. The Plant cell 98 21750236
1993 Xenopus A-myb is expressed during early spermatogenesis. Oncogene 84 8510936
1998 The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. Molecular and cellular biology 82 9418884
2017 MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene. The Journal of pathology 79 29149504
2015 A MYB/ZML Complex Regulates Wound-Induced Lignin Genes in Maize. The Plant cell 79 26566917
2012 Brassica napus PHR1 gene encoding a MYB-like protein functions in response to phosphate starvation. PloS one 78 22952851
2017 A MYB transcription factor, DcMYB6, is involved in regulating anthocyanin biosynthesis in purple carrot taproots. Scientific reports 76 28345675
2018 MYB and MYBL1 in adenoid cystic carcinoma: diversity in the mode of genomic rearrangement and transcripts. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 75 29410490
2009 A MYB transcription factor regulates anthocyanin biosynthesis in mangosteen (Garcinia mangostana L.) fruit during ripening. Planta 75 19306102
2008 Identification of target genes for a MYB-type anthocyanin regulator in Gerbera hybrida. Journal of experimental botany 71 18725377
2016 Phenylpropanoids Accumulation in Eggplant Fruit: Characterization of Biosynthetic Genes and Regulation by a MYB Transcription Factor. Frontiers in plant science 67 26858726
2017 MYB, MYBL1, MYBL2 and NFIB gene alterations and MYC overexpression in salivary gland adenoid cystic carcinoma. Histopathology 66 28594149
1994 Murine A-myb: evidence for differential splicing and tissue-specific expression. Oncogene 66 8084617
2008 Crystal structure of the polyextremophilic alpha-amylase AmyB from Halothermothrix orenii: details of a productive enzyme-substrate complex and an N domain with a role in binding raw starch. Journal of molecular biology 65 18387632
2019 A MYB Triad Controls Primary and Phenylpropanoid Metabolites for Pollen Coat Patterning. Plant physiology 62 30755473
2014 A unique mutation in a MYB gene cosegregates with the nectarine phenotype in peach. PloS one 62 24595269
1994 The human A-myb protein is a strong activator of transcription. Oncogene 57 8058310
1976 Mapping of mutations affecting synthesis of exocellular enzymes in Bacillus subtilis. Identity of the sacUh, amyB and pap mutations. Molecular & general genetics : MGG 57 827683
2021 A teosinte-derived allele of a MYB transcription repressor confers multiple disease resistance in maize. Molecular plant 55 34271176
2006 Purine biosynthesis, riboflavin production, and trophic-phase span are controlled by a Myb-related transcription factor in the fungus Ashbya gossypii. Applied and environmental microbiology 53 16820505
2012 FlbD, a Myb transcription factor of Aspergillus nidulans, is uniquely involved in both asexual and sexual differentiation. Eukaryotic cell 52 22798393
2004 Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes. Genetics 51 15489525
2000 A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells. The Journal of biological chemistry 51 10692454
1997 Myb26: a MYB-like protein of pea flowers with affinity for promoters of phenylpropanoid genes. The Plant journal : for cell and molecular biology 51 9450341
2022 MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma. Cell death & disease 48 35987690
2001 A plant gene encoding a Myb-like protein that binds telomeric GGTTTAG repeats in vitro. The Journal of biological chemistry 47 11278537
1996 Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. Blood 46 8634438
2013 A Myb transcription factor regulates genes of the phenylalanine pathway in maritime pine. The Plant journal : for cell and molecular biology 45 23451763
2020 ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma. Oncogenesis 44 32001675
2004 Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias. Blood 44 15187020
2014 Peace, a MYB-like transcription factor, regulates petal pigmentation in flowering peach 'Genpei' bearing variegated and fully pigmented flowers. Journal of experimental botany 43 24453228
2003 Association of decreased expression of a Myb transcription factor with the TPD (tapping panel dryness) syndrome in Hevea brasiliensis. Plant molecular biology 43 12602890
2016 CLAUSA Is a MYB Transcription Factor That Promotes Leaf Differentiation by Attenuating Cytokinin Signaling. The Plant cell 41 27385816
1998 The A-Myb transcription factor is a marker of centroblasts in vivo. Journal of immunology (Baltimore, Md. : 1950) 40 9510180
1997 Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules. The Biochemical journal 40 9210395
2019 A MYB-related transcription factor from sheepgrass, LcMYB2, promotes seed germination and root growth under drought stress. BMC plant biology 39 31852429
2013 NbPHAN, a MYB transcriptional factor, regulates leaf development and affects drought tolerance in Nicotiana benthamiana. Physiologia plantarum 39 23387304
1994 The chicken A-myb protein is a transcriptional activator. Oncogene 38 8058311
2019 A MYB transcription factor is a candidate to control pungency in Capsicum annuum. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 37 30607439
1995 Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains. FEBS letters 37 7821437
2019 AH2 encodes a MYB domain protein that determines hull fate and affects grain yield and quality in rice. The Plant journal : for cell and molecular biology 36 31357245
2005 The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Molecular biology of the cell 36 16055500
2012 A MYB transcription factor from the grey mangrove is induced by stress and confers NaCl tolerance in tobacco. Journal of experimental botany 35 22904269
2019 Detecting MYB and MYBL1 fusion genes in tracheobronchial adenoid cystic carcinoma by targeted RNA-sequencing. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 34 31028361
2019 A Cyclin A-Myb-MuvB-Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles. PLoS genetics 33 31291240
2017 Characterization and functional analysis of a MYB gene (GbMYBFL) related to flavonoid accumulation in Ginkgo biloba. Genes & genomics 33 29892898
2014 MYT3, a Myb-like transcription factor, affects fungal development and pathogenicity of Fusarium graminearum. PloS one 33 24722578
2012 A Myb transcription factor of Phytophthora sojae, regulated by MAP kinase PsSAK1, is required for zoospore development. PloS one 33 22768262
2022 Rearrangements, Expression, and Clinical Significance of MYB and MYBL1 in Adenoid Cystic Carcinoma: A Multi-Institutional Study. Cancers 32 35954356
2023 A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis. Nature communications 31 36990976
2019 A rice gene, OsPL, encoding a MYB family transcription factor confers anthocyanin synthesis, heat stress response and hormonal signaling. Gene 31 30858135
2020 A MYB transcription factor, BnMYB2, cloned from ramie (Boehmeria nivea) is involved in cadmium tolerance and accumulation. PloS one 30 32421756
2016 EjODO1, a MYB Transcription Factor, Regulating Lignin Biosynthesis in Developing Loquat (Eriobotrya japonica) Fruit. Frontiers in plant science 30 27695460
2014 Methylation affects transposition and splicing of a large CACTA transposon from a MYB transcription factor regulating anthocyanin synthase genes in soybean seed coats. PloS one 30 25369033
2012 A MYB transcription factor controls flower color in soybean. The Journal of heredity 29 23048163
2009 RFX2 is a candidate downstream amplifier of A-MYB regulation in mouse spermatogenesis. BMC developmental biology 29 20003220
1994 The A-myb gene is preferentially expressed in tonsillar CD38+, CD39-, and sIgM- B lymphocytes and in Burkitt's lymphoma cell lines. Journal of immunology (Baltimore, Md. : 1950) 29 8021494
2021 SlPHL1, a MYB-CC transcription factor identified from tomato, positively regulates the phosphate starvation response. Physiologia plantarum 28 34263934
2019 A non-LTR retrotransposon activates anthocyanin biosynthesis by regulating a MYB transcription factor in Capsicum annuum. Plant science : an international journal of experimental plant biology 28 31481212
1997 A-myb is expressed in bovine vascular smooth muscle cells during the late G1-to-S phase transition and cooperates with c-myc to mediate progression to S phase. Molecular and cellular biology 28 9111313
1997 Linking Myb to the cell cycle: cyclin-dependent phosphorylation and regulation of A-Myb activity. Oncogene 27 9285555
2023 A MYB activator, DcMYB11c, regulates carrot anthocyanins accumulation in petiole but not taproot. Plant, cell & environment 26 37338208
2020 MORE FLORET1 Encodes a MYB Transcription Factor That Regulates Spikelet Development in Rice. Plant physiology 24 32680975
2020 MULTI-FLORET SPIKELET 2, a MYB Transcription Factor, Determines Spikelet Meristem Fate and Floral Organ Identity in Rice. Plant physiology 24 32723808
2015 Chicken gga-miR-181a targets MYBL1 and shows an inhibitory effect on proliferation of Marek's disease virus-transformed lymphoid cell line. Poultry science 24 26500265
2013 A MYB coiled-coil transcription factor interacts with NSP2 and is involved in nodulation in Lotus japonicus. The New phytologist 24 24400899
2012 Contribution ratios of amyA, amyB, amyC genes to high-level α-amylase expression in Aspergillus oryzae. Bioscience, biotechnology, and biochemistry 23 22878189

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