Affinage

MMP17

Matrix metalloproteinase-17 · UniProt Q9ULZ9

Length
603 aa
Mass
66.7 kDa
Annotated
2026-06-10
33 papers in source corpus 15 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/9 claims corpus-supported (89%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MMP17 (MT4-MMP) is a GPI-anchored, cell-surface matrix metalloproteinase that regulates tissue remodeling and stem-cell niche function through both proteolytic and non-catalytic scaffolding activities (PMID:10567400, PMID:25963716, PMID:34795242). It is the first GPI-anchored MMP, attached to the membrane via a sequence-dependent GPI unit and releasable by PI-PLC, and is also shed by an endogenous metalloproteinase (PMID:10567400). The enzyme matures through furin cleavage in the Golgi to a membrane-resident form, carries a single N-glycosylation site at Asn318, and its hemopexin domain harbors an intrinsic inhibitory signal that restrains trafficking and enzyme maturation (PMID:28531887, PMID:16686598). At the surface it forms homophilic oligomers and is internalized by a clathrin-independent, CDC42/RhoA-dependent CLIC/GEEC route into early endosomes for autodegradation or recycling (PMID:26663028). Catalytically, MT4-MMP has TNFα-convertase activity and a narrow ECM substrate range limited largely to fibrinogen/fibrin, and notably does not activate pro-MMP2, distinguishing it from other membrane-type MMPs; its activity is inhibited by TIMP-1, -2, and -3 (PMID:10799478). Its physiological substrates include osteopontin, whose cleavage controls vascular smooth muscle cell maturation via JNK signaling such that loss of Mmp17 produces dysfunctional VSMCs and susceptibility to angiotensin-II-induced thoracic aortic aneurysm, and PERIOSTIN, whose cleavage by smooth-muscle-derived MMP17 supports BMP-antagonist supply, intestinal stem cell maintenance, YAP activity, and epithelial repair after injury (PMID:25963716, PMID:34795242). A human R373H mutation that blocks MMP17 expression links the gene to the aortic vessel-wall phenotype (PMID:25963716). Independently of proteolysis, MT4-MMP directly associates with EGFR to enhance EGFR phosphorylation and drive proliferation through CDK4/Rb (PMID:25320013). In disease, tumor-derived (not host) MT4-MMP requires its catalytic activity to drive the angiogenic switch and metastasis, and it deficiency accelerates atherosclerosis through CCR5-dependent patrolling-monocyte recruitment (PMID:22262494, PMID:29500407).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1999 High

    Established the unique membrane attachment mode of MT4-MMP, defining it as the first GPI-anchored MMP rather than a transmembrane membrane-type MMP.

    Evidence [3H]ethanolamine metabolic labeling and PI-PLC release in transfected cells

    PMID:10567400

    Open questions at the time
    • Did not resolve which endogenous metalloproteinase sheds MT4-MMP
    • Functional consequences of GPI anchoring vs shedding not addressed
  2. 1999 Medium

    Resolved the discrepancy in the original cDNA by identifying the true full-length ORF, enabling expression of functional MT4-MMP protein.

    Evidence 5' RACE and cDNA cloning with expression validation by Western blot

    PMID:10471807

    Open questions at the time
    • Single lab
    • Did not characterize protein function
  3. 2000 High

    Defined the catalytic specificity of MT4-MMP, showing TNFα-convertase activity and a narrow ECM substrate range while ruling out pro-MMP2 activation, separating it functionally from MT1/2/3-MMP.

    Evidence Recombinant catalytic domain peptide/fusion cleavage, COS-7 shedding assay, TIMP inhibition, and pro-MMP2 activation assay

    PMID:10799478

    Open questions at the time
    • In vitro TNFα cleavage not shown to be physiologically dominant
    • Full physiological substrate repertoire unknown
  4. 2005 Medium

    Implicated MT4-MMP in cartilage catabolism by linking its GPI-anchored activity to ADAMTS4 processing and IL-1-induced aggrecanolysis.

    Evidence Bovine cartilage explants with mannosamine GPI-inhibition and Western blots for aggrecan, MT4-MMP, and ADAMTS4

    PMID:15780640

    Open questions at the time
    • Pharmacological inhibition is indirect for MT4-MMP function
    • Direct MT4-MMP cleavage of ADAMTS4 not biochemically reconstituted
  5. 2006 High

    Located an intrinsic maturation/trafficking control within the hemopexin domain, explaining why MT4-MMP behaves differently from other MT-MMPs.

    Evidence MT1/MT4-MMP domain-swap chimeras with surface biotinylation, immunofluorescence, and activity assays

    PMID:16686598

    Open questions at the time
    • Molecular nature of the inhibitory signal undefined
    • Studied in chimeric context rather than native protein
  6. 2007 Medium

    Mapped in vivo expression and challenged the TNFα-sheddase model by showing normal LPS-induced TNFα release in MT4-MMP-null macrophages.

    Evidence MT4-MMP KO/LacZ reporter mouse, β-gal staining, RT-PCR, and macrophage TNFα release assay

    PMID:17825051

    Open questions at the time
    • Does not exclude TNFα cleavage in other contexts
    • Did not identify the dominant in vivo substrate
  7. 2012 High

    Demonstrated that catalytic activity of tumor-derived MT4-MMP is required for angiogenesis and metastasis, isolating a proteolysis-dependent oncogenic function.

    Evidence E249A active-site mutant, subcutaneous tumors in RAG1-deficient and MT4-MMP-null host mice, tumor growth and lung colonization assays

    PMID:22262494

    Open questions at the time
    • Pro-angiogenic substrate not identified
    • Mechanism of the angiogenic switch unresolved
  8. 2014 Medium

    Uncovered a non-catalytic scaffold function whereby MT4-MMP physically associates with EGFR to amplify signaling and proliferation.

    Evidence Co-IP, EGFR phosphorylation and proliferation assays, CDK4/Rb analysis, and catalytic mutant comparison

    PMID:25320013

    Open questions at the time
    • Direct vs indirect EGFR binding not structurally defined
    • Single lab without reciprocal validation
  9. 2015 High

    Identified osteopontin as a physiological substrate linking MT4-MMP proteolysis to VSMC maturation and aortic wall integrity, with a human mutation tying the gene to aneurysm susceptibility.

    Evidence Mmp17 KO mice, angiotensin-II aneurysm model, rescue with active enzyme or osteopontin fragment, JNK analysis, and human R373H mutation

    PMID:25963716

    Open questions at the time
    • Direct biochemical osteopontin cleavage site mapping not detailed
    • How JNK output is set by the osteopontin fragment unresolved
  10. 2016 Medium

    Defined MT4-MMP surface oligomerization and its clathrin-independent CDC42/RhoA-dependent internalization and recycling itinerary.

    Evidence Co-IP of differentially tagged MT4-MMP, reducing/non-reducing blots, antibody-feeding confocal assays, biotinylation, and CDC42/RhoA/caveolin-1 siRNA

    PMID:26663028

    Open questions at the time
    • Functional purpose of homophilic complexes unclear
    • Trafficking studied in cell lines only
  11. 2017 Medium

    Established the biosynthetic maturation pathway, showing furin cleavage in the Golgi yields the mature membrane form and identifying Asn318 as the sole N-glycosylation site.

    Evidence Iodixanol organelle fractionation, glycosidase treatment, and N-glycosylation site mutagenesis in melanoma cells

    PMID:28531887

    Open questions at the time
    • Functional role of glycosylation not tested
    • Single cell-type context
  12. 2018 High

    Revealed a vasculoprotective role in atherosclerosis, with MT4-MMP loss accelerating disease via CCR5-dependent patrolling-monocyte recruitment.

    Evidence MT4-MMP KO crossed to atherosclerosis model, intravital microscopy, flow cytometry, macrophage functional assays, and CCR5 inhibitor rescue

    PMID:29500407

    Open questions at the time
    • Direct MT4-MMP substrate controlling monocyte adhesion not identified
    • Catalytic vs scaffold dependence not resolved
  13. 2019 Medium

    Connected MT4-MMP to invasive cancer cell motility through binding Tks5 and PDGFRα to activate Src and Rho/Cdc42.

    Evidence Overexpression in FaDu cells, 3D invasion assays, co-IP with Tks5 and PDGFRα, and Src/Rho/Cdc42 activity assays

    PMID:31813546

    Open questions at the time
    • Overexpression system may not reflect endogenous behavior
    • Direct vs indirect partner binding not dissected
  14. 2021 High

    Identified PERIOSTIN cleavage by smooth-muscle MMP17 as the niche signal supporting BMP antagonism, intestinal stem cell maintenance, and epithelial repair.

    Evidence Mmp17 KO mice, inflammation/irradiation injury models, organoid assays, PERIOSTIN cleavage assay, and YAP analysis

    PMID:34795242

    Open questions at the time
    • Precise BMP-antagonist link to periostin fragment incompletely mapped
    • Cleavage site on periostin not detailed
  15. 2023 Medium

    Extended MMP17's niche-regulatory role to goblet cell maturation and anti-helminth resistance, while excluding NOTCH and cytokine changes as mechanism.

    Evidence Mmp17 KO mice, T. muris and C. rodentium infection models, and goblet cell marker expression analysis

    PMID:37869014

    Open questions at the time
    • Effector substrate driving goblet cell phenotype unknown
    • Mechanism remains incompletely defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How MT4-MMP's catalytic and non-catalytic (EGFR-scaffold) functions are coordinated across tissues, and which substrate cleavages drive each in vivo phenotype, remains unresolved.
  • No unifying model linking proteolysis-dependent and scaffold functions
  • Substrates underlying monocyte and goblet cell phenotypes unidentified
  • No structural model of substrate or EGFR engagement

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 3 GO:0016787 hydrolase activity 2 GO:0060089 molecular transducer activity 1
Localization
GO:0005886 plasma membrane 3 GO:0005768 endosome 1 GO:0005794 Golgi apparatus 1
Partners
EGFRPDGFRATKS5

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 MT4-MMP (MMP17) is a GPI-anchored proteinase — the first GPI-anchored member of the MMP family. [3H]ethanolamine labeling incorporated into the GPI unit in a sequence-dependent manner, and phosphatidylinositol-specific phospholipase C treatment released MT4-MMP from the cell surface of transfected cells. MT4-MMP is also shed from the cell surface by an endogenous metalloproteinase. Metabolic labeling with [3H]ethanolamine, PI-PLC treatment of transfected cells, cell surface release assay The Journal of biological chemistry High 10567400
2000 Mouse MT4-MMP catalytic domain has TNF-alpha convertase activity: it efficiently cleaves a peptide spanning the pro-TNFα cleavage site, cleaves a GST-pro-TNFα fusion protein in vitro, and sheds pro-TNFα when co-transfected in COS-7 cells. However, it does not activate pro-MMP2 and shows very limited activity against ECM components except fibrinogen and fibrin. Catalytic activity is inhibited by TIMP-1, -2, and -3. E. coli expression/refolding of recombinant catalytic domain, synthetic peptide cleavage assay, GST-fusion protein cleavage, co-transfection shedding assay in COS-7 cells, TIMP inhibition assay The Journal of biological chemistry High 10799478
1999 The originally reported human MT4-MMP cDNA (Puente et al. 1996) lacked the full ORF and failed to express protein. A new major transcript with an extended open reading frame was identified by 5' RACE and encodes 67 and 71 kDa translation products — the functional MT4-MMP protein. 5' RACE, cDNA cloning, protein expression in transfected cells (Western blot) FEBS letters Medium 10471807
2000 MT4-MMP expressed in COS-7 cells localizes to the cell surface but does not activate pro-MMP2, distinguishing it functionally from MT1-, MT2-, and MT3-MMP. COS-7 cell transfection, cell-surface expression assay, pro-MMP2 activation assay The Journal of biological chemistry Medium 10799478
2006 The hemopexin domain of MT4-MMP, when substituted into MT1-MMP chimeras, blocks propeptide processing, prevents trafficking to the plasma membrane (retained in ER), and abolishes pro-MMP2 activation and gelatin degradation. The MT4-MMP hemopexin domain therefore carries an intrinsic inhibitory signal for enzyme maturation and trafficking. MT1-MT4-MMP chimera construction, cell-surface biotinylation, indirect immunofluorescence, pro-MMP2 activation assay, gelatin degradation assay The Biochemical journal High 16686598
2007 In vivo, MT4-MMP is expressed primarily in cerebrum, lung, spleen, intestine and uterus; specifically in neurons (cerebrum), smooth muscle cells (intestine, uterus), and macrophages (lung alveolar/intraperitoneal space). LPS-induced TNF-α release from MT4-MMP-null macrophages was not different from wild-type, and MT4-MMP mRNA was repressed by LPS stimulation — arguing against a dominant role as a TNFα sheddase in macrophages in vivo. MT4-MMP KO mouse with LacZ reporter, β-galactosidase staining, RT-PCR, TNF-α release assay from macrophages Genes to cells : devoted to molecular & cellular mechanisms Medium 17825051
2005 MT4-MMP is required for IL-1-induced aggrecanolysis in bovine cartilage explants. Blocking GPI-anchor synthesis with mannosamine (inhibiting MT4-MMP membrane anchoring) blocked IL-1-mediated aggrecan cleavage, MT4-MMP induction, and ADAMTS4 processing (p68→p53 conversion and release). This supports MT4-MMP-mediated processing of resident ADAMTS4 as the mechanism of aggrecanolysis. Bovine cartilage explant treatment with IL-1, Western blot for aggrecan fragments, MT4-MMP, and ADAMTS4, mannosamine GPI-anchor inhibition, esculetin MMP inhibition Osteoarthritis and cartilage Medium 15780640
2012 The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic effects in breast cancer. Glutamic acid 249→Alanine active-site mutation abolished the MT4-MMP-induced angiogenic switch, tumor growth acceleration, and lung colonization. Tumor-derived (not host-derived) MT4-MMP drives angiogenesis; MT4-MMP-deficient host mice were unaffected. Site-directed mutagenesis (E249A), subcutaneous tumor implantation in RAG1-deficient mice, MT4-MMP-null mouse host experiments, tumor growth and lung colonization assays International journal of cancer High 22262494
2014 MT4-MMP directly associates with EGFR at the cell surface and enhances EGFR phosphorylation in response to TGFα and EGF, driving cancer cell proliferation through CDK4 activation and retinoblastoma protein inactivation. These effects on proliferation and EGFR activation do not require MT4-MMP metalloprotease activity. Co-immunoprecipitation, EGFR phosphorylation assays, cell proliferation assays, CDK4/Rb pathway analysis, catalytic mutant comparison Cancer research Medium 25320013
2015 MMP17/MT4-MMP cleaves osteopontin, and this cleavage regulates vascular smooth muscle cell maturation via c-Jun N-terminal kinase (JNK) signaling during aorta wall development. Loss of Mmp17 in mice results in dysfunctional VSMCs and altered ECM, leading to increased susceptibility to angiotensin-II-induced thoracic aortic aneurysm. Re-expression of catalytically active Mmp17 or the N-terminal osteopontin fragment rescued part of the vessel-wall phenotype. Mmp17 knockout mouse model, angiotensin-II-induced aneurysm model, lentiviral re-expression of active Mmp17 or osteopontin fragment, JNK signaling analysis, human patient mutation (R373H) blocking expression Circulation research High 25963716
2016 MT4-MMP forms homophilic complexes (oligomers and dimers) at the cell surface. It is internalized via the clathrin-independent carriers/GPI-enriched early endosomal compartments (CLIC/GEEC) pathway into early endosomes, where it is either autodegraded or recycled to the cell surface. Internalization was reduced by CDC42 or RhoA siRNA silencing but not by caveolin-1 or clathrin pathway inhibitors. Co-immunoprecipitation of FLAG- and Myc-tagged MT4-MMP, reducing/non-reducing immunoblotting, antibody feeding assay with confocal microscopy, cell surface biotinylation/Western blot, siRNA knockdown of CDC42/RhoA/caveolin-1 The FEBS journal Medium 26663028
2017 MT4-MMP in melanoma cells is processed by furin cleavage in the Golgi apparatus. The 69 kDa form is the intracellular precursor and the 58 kDa form is the mature protein present at the cell membrane. Asn318 was identified as the single N-glycosylation site of MT4-MMP. Iodixanol gradient organelle fractionation, glycosidase treatment, site-directed mutagenesis of N-glycosylation sites, Western blotting Cellular physiology and biochemistry Medium 28531887
2018 MT4-MMP deficiency in mice increases adhesion of patrolling monocytes to inflamed endothelia, elevates Mafb+AIM+ macrophage accumulation at early atherosclerotic lesions, and accelerates atherosclerosis. MT4-MMP-null Mafb+AIM+ macrophages show higher AIM and CD36 expression, increased resistance to apoptosis, and avid acLDL binding. CCR5 inhibition blocks the enhanced recruitment of MT4-MMP-null patrolling monocytes and alleviates atherosclerosis acceleration. MT4-MMP KO mouse crossed to atherosclerosis model, intravital microscopy, flow cytometry, peritoneal macrophage functional assays (apoptosis, acLDL binding), CCR5 inhibitor treatment Nature communications High 29500407
2019 MT4-MMP promotes invadopodia formation and amoeboid-like cell movement in head and neck cancer cells. Mechanistically, MT4-MMP binds Tks5 and PDGFRα, leading to Src activation (invadopodia), and stimulates Rho and Cdc42 GTPases (amoeboid movement). MT4-MMP expression increased gelatin degradation in 3D assays. MT4-MMP overexpression in FaDu cells, 3D collagen/gelatin invasion assays, co-immunoprecipitation of MT4-MMP with Tks5 and PDGFRα, Src/Rho/Cdc42 activity assays Biochemical and biophysical research communications Medium 31813546
2021 MMP17, exclusively expressed by smooth muscle cells in the intestine, is required for intestinal epithelial repair after inflammation- or irradiation-induced injury. MMP17 affects intestinal epithelial reprogramming indirectly by cleaving the matricellular protein PERIOSTIN, and smooth muscle-derived MMP17 promotes BMP antagonist supply essential for intestinal stem cell maintenance and YAP activity. Mmp17 KO mouse, intestinal injury models (inflammation, irradiation), intestinal organoid assays, PERIOSTIN cleavage assay, YAP activity analysis, single-cell/cell-type-specific expression analysis Nature communications High 34795242
2023 MMP17 expressed in smooth muscle cells and lamina propria macrophages of the intestine extrinsically regulates goblet cell maturation. Mmp17 KO mice show elevated goblet-cell-associated genes (CLCA1, RELM-β) and increased resistance to low-dose Trichuris muris helminth infection. The mechanism does not appear to involve NOTCH pathway changes or altered cytokine levels. Mmp17 KO mouse, helminth (T. muris) infection model, Citrobacter rodentium infection model, gene/protein expression analysis of goblet cell markers Frontiers in immunology Medium 37869014

Source papers

Stage 0 corpus · 33 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2. The Journal of biological chemistry 167 10799478
1999 Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. The Journal of biological chemistry 136 10567400
2008 MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer. Cancer metastasis reviews 115 18286233
2005 Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Osteoarthritis and cartilage 70 15780640
1999 Overview of expression of matrix metalloproteinases (MMP-17, MMP-18, and MMP-20) in cultured human cells. Matrix biology : journal of the International Society for Matrix Biology 56 10372554
2015 Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice. Circulation research 55 25963716
2009 Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture. Journal of cellular and molecular medicine 42 19426156
2018 Expression of MT4-MMP, EGFR, and RB in Triple-Negative Breast Cancer Strongly Sensitizes Tumors to Erlotinib and Palbociclib Combination Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research 39 30504427
1999 Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts. FEBS letters 38 10471807
2018 MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis. Nature communications 36 29500407
2014 EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP. Cancer research 36 25320013
2007 Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase. Genes to cells : devoted to molecular & cellular mechanisms 34 17825051
2021 Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage. Nature communications 28 34795242
2012 The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects. International journal of cancer 20 22262494
2019 MT4-MMP promotes invadopodia formation and cell motility in FaDu head and neck cancer cells. Biochemical and biophysical research communications 18 31813546
2020 MMPphg from the thermophilic Meiothermus bacteriophage MMP17 as a potential antimicrobial agent against both Gram-negative and Gram-positive bacteria. Virology journal 15 32843096
2016 Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells. The FEBS journal 15 26663028
2011 Isolation and characterization of a new bacteriophage MMP17 from Meiothermus. Extremophiles : life under extreme conditions 15 21225300
2017 Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo. PloS one 13 28926609
2011 Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice. PloS one 12 21347258
2006 MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells. The Biochemical journal 12 16686598
2023 Molecular Mechanisms Driven by MT4-MMP in Cancer Progression. International journal of molecular sciences 8 37373092
2022 Expression and clinical significance of TYRP1, ABCB5, and MMP17 in sinonasal mucosal melanoma. Cancer biomarkers : section A of Disease markers 7 36373310
2017 Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 7 28531887
2024 SH3GL2 and MMP17 as lung adenocarcinoma biomarkers: a machine-learning based approach. Biochemistry and biophysics reports 4 38571554
2023 Doxycycline hydrochloride inhibits the progress of malignant rhabdoid tumor of kidney by targeting MMP17 and MMP1 through PI3K-Akt signaling pathway. European journal of pharmacology 3 38158115
2025 Plasma concentration of MMP-17 is elevated in boys with cryptorchidism and correlates with HSP-70. Scientific reports 2 39747260
2024 CCZ1 Accelerates the Progression of Cervical Squamous Cell Carcinoma by Promoting MMP2/MMP17 Expression. Biomedicines 2 39062041
2024 The Effect of Curcumin on the Activity of MMP-17 and MMP-24 in Hepatocytes of Mice Exposed to Thioacetamide. Reports of biochemistry & molecular biology 1 40330566
2023 The Relationship Between MMP17 Variants and Ischemic Stroke Risk in the Population from Shaanxi Province in China. Pharmacogenomics and personalized medicine 1 36733691
2019 MT4-MMP Modulates the Expression of miRNAs in Breast Cancer Cells. Archives of medical research 1 30792164
2023 Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection. Frontiers in immunology 0 37869014
2023 Elevated Plasma Levels of MT4-MMP and MT6-MMP; A New Observation in Patients with Thyroid Nodules. Archives of Iranian medicine 0 38310435

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