Affinage

MMP11

Stromelysin-3 · UniProt P24347

Length
488 aa
Mass
54.6 kDa
Annotated
2026-04-28
70 papers in source corpus 20 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MMP11 (stromelysin-3) is a zinc-dependent matrix metalloproteinase that functions as a paracrine and autocrine mediator of extracellular matrix remodeling, cell survival, and cell migration, with prominent roles in stromal–epithelial crosstalk during development, tissue repair, and tumor progression. Its catalytic domain features a distinctive tunnel-shaped S1' pocket, and its proteolytic activity—activated intracellularly by furin cleavage of the prodomain—is required for anti-apoptotic signaling through MAPK and AKT, for degradation of Collagen VI to drive fibronectin deposition and cell migration during organogenesis, and for promotion of tumor cell proliferation and invasion via PI3K/AKT and NF-κB pathways (PMID:11254383, PMID:12845673, PMID:36465133, PMID:39639765). MMP11 expression in stromal fibroblasts and cancer-associated fibroblasts is induced by IL-1β, TGF-β, IGF-1/JAK1/STAT3, and androgen/MafB signaling, and is epigenetically maintained by KDM6A-mediated H3K27me3 demethylation at its promoter (PMID:15272933, PMID:29731870, PMID:36465133, PMID:41212163). Beyond ECM degradation, MMP11 stabilizes Smad2 protein by inhibiting its ubiquitin–proteasome-mediated degradation, linking it to non-proteolytic modulation of TGF-β signaling (PMID:33649832).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1992 Medium

    Mapping MMP11 to chromosome 22q11.2, distinct from other MMP gene clusters on chromosomes 11 and 16, established it as a member of a separate MMP subfamily and set the stage for understanding its divergent substrate specificity.

    Evidence In situ hybridization and somatic cell hybrid analysis

    PMID:1639418

    Open questions at the time
    • No functional or enzymatic characterization accompanied the mapping
  2. 1999 High

    Knockout mouse studies revealed that MMP11 restrains smooth muscle cell and leukocyte accumulation after vascular injury, providing the first in vivo loss-of-function evidence that MMP11 limits pathological tissue remodeling rather than simply promoting ECM degradation.

    Evidence MMP-11 knockout mice subjected to femoral artery electric injury, with immunocytochemistry and morphometric analysis

    PMID:10591662

    Open questions at the time
    • Specific substrate(s) responsible for the anti-remodeling effect were not identified
    • Mechanism by which MMP11 limits leukocyte accumulation was not resolved
  3. 2001 High

    The crystal structure of the MMP11 catalytic domain revealed a unique tunnel-shaped S1' pocket unlike the open pocket of other MMPs, explaining its restricted substrate repertoire and providing the structural basis for inhibitor design.

    Evidence X-ray crystallography of catalytic domain–phosphinic inhibitor complex

    PMID:11254383

    Open questions at the time
    • No endogenous substrate was co-crystallized
    • Full-length structure including prodomain and hemopexin domain remains unresolved
  4. 2003 High

    Demonstration that MMP11 catalytic activity is required for suppression of apoptosis via MAPK and AKT activation in breast cancer cells established it as a pro-survival protease, not merely a matrix-degrading enzyme.

    Evidence Catalytically inactive mutant and batimastat inhibition in MCF-7 3D Matrigel culture with FACS, TUNEL, and western blot

    PMID:12845673

    Open questions at the time
    • The direct substrate mediating survival signaling was not identified
    • Whether this mechanism operates in non-transformed epithelial cells is unknown
  5. 2004 Medium

    Identification of IL-1β, IL-2, TGF-β, fibronectin, and collagen V as inducers of MMP11 in fibroblasts defined the stromal signaling context that drives MMP11 expression in the tumor microenvironment.

    Evidence Competitive quantitative RT-PCR of cytokine/ECM-treated NIH3T3 and primary MEFs

    PMID:15272933

    Open questions at the time
    • Transcription factor binding sites mediating each stimulus were not mapped
    • Induction was measured at mRNA level only, without protein or enzymatic activity confirmation
  6. 2011 Medium

    Placing MMP11 downstream of the Hedgehog effector Gli1 via epistasis experiments expanded the repertoire of oncogenic transcriptional programs converging on MMP11 to drive invasion.

    Evidence Gli1 overexpression with MMP-11 siRNA rescue in MDA-MB-231 cells, migration/invasion assays, in vivo metastasis model

    PMID:21442356

    Open questions at the time
    • Whether Gli1 directly binds the MMP11 promoter was not tested
    • Generalizability beyond ER-negative breast cancer lines unconfirmed
  7. 2018 Medium

    Convergent studies established STAT3 as a central transcriptional activator of MMP11 downstream of both IGF-1/JAK1 and gastrin signaling in gastric cancer, linking receptor tyrosine kinase and G-protein-coupled receptor pathways to MMP11 induction.

    Evidence Pharmacological inhibitors (NT157, piceatannol), STAT3 siRNA, and western blot in SGC-7901 cells; GAST gain/loss-of-function with STAT3 pathway analysis

    PMID:29731870 PMID:32922036

    Open questions at the time
    • Direct STAT3 binding to MMP11 promoter elements not confirmed by ChIP
    • GAST/STAT3/MMP11 axis supported only by expression-level assays with limited mechanistic depth
  8. 2018 Medium

    Epistasis experiments positioning MMP11 upstream of NF-κB p65 phosphorylation in thyroid cancer cells identified a second major intracellular signaling axis through which MMP11 promotes proliferation and migration.

    Evidence MMP-11 overexpression/siRNA and p65 knockdown in K1 and BCPAP thyroid cancer cells, western blot for phospho-p65 and cyclin D1

    PMID:30171715

    Open questions at the time
    • Whether NF-κB activation requires MMP11 catalytic activity was not tested
    • Intermediate between MMP11 and NF-κB activation is unknown
  9. 2021 Medium

    Two studies expanded MMP11's mechanism beyond matrix remodeling: macrophage-expressed MMP11 drives paracrine cancer cell migration via CCL2/CCR2/MAPK, and MMP11 stabilizes Smad2 by inhibiting its proteasomal degradation, revealing a non-catalytic or non-canonical protease function.

    Evidence Co-culture of MMP11-overexpressing macrophages with HER2+ breast cancer cells, CCL2/CCR2 pathway analysis; Smad2 ubiquitination assays, MMP11 knockdown/overexpression with xenograft validation

    PMID:33649832 PMID:34775491

    Open questions at the time
    • Whether Smad2 stabilization requires MMP11 catalytic activity is not established
    • The mechanism by which MMP11 inhibits Smad2 ubiquitination (direct interaction vs. intermediate) is undefined
    • Macrophage CCL2 induction mechanism downstream of MMP11 is unknown
  10. 2022 High

    Identification of Collagen VI as a direct MMP11 substrate in vivo, with downstream fibronectin deposition driving cell migration during genital development, provided the first defined substrate-to-phenotype pathway for MMP11 in a developmental context.

    Evidence MafB knockout mice, androgen treatment, recombinant MMP11 ColVI cleavage, fibronectin deposition and focal adhesion analysis in ex vivo organ culture

    PMID:36465133

    Open questions at the time
    • Other physiological substrates remain largely unidentified
    • Whether ColVI degradation mediates MMP11's pro-tumorigenic effects was not tested
  11. 2022 Medium

    A germline gain-of-function variant (p.Pro78Ser) in the MMP11 prodomain that enhances invasion and proliferation in colorectal cancer cells linked prodomain integrity to catalytic regulation and familial cancer predisposition.

    Evidence Whole exome sequencing with family co-segregation, in silico structural modeling, P78S variant expression in HCT116 cells with invasion/proliferation assays

    PMID:36093604

    Open questions at the time
    • Whether P78S causes premature furin cleavage or altered autoinhibition was not biochemically demonstrated
    • Only one family studied; population-level significance unknown
  12. 2024 High

    CAF-derived MMP11, induced by tumor cell TGF-β1/pSmad2-3, was shown to drive pancreatic cancer cell proliferation and invasion via PI3K/AKT rather than ECM remodeling, establishing a non-matrix paracrine signaling axis in the tumor microenvironment.

    Evidence CAF-cancer cell co-culture, MMP11 siRNA with recombinant MMP11 rescue, PI3K/AKT western blot, xenograft co-injection, scRNA-seq

    PMID:39639765

    Open questions at the time
    • The direct target of MMP11 protease activity that activates PI3K/AKT is unidentified
    • Whether this axis operates in non-pancreatic cancers is untested
  13. 2025 High

    ChIP-based identification of KDM6A-mediated H3K27me3 demethylation at the MMP11 promoter provided the first epigenetic mechanism maintaining MMP11 transcription in metastatic prostate cancer.

    Evidence GSK-J4 inhibition and KDM6A-specific siRNA in LNCaP cells, ChIP for H3K27me3, RT-qPCR and western blot

    PMID:41212163

    Open questions at the time
    • Whether KDM6A epigenetic regulation of MMP11 is cancer-type-specific or general is unknown
    • Upstream signals recruiting KDM6A to the MMP11 locus are not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • The identity of MMP11's direct substrates that mediate its intracellular signaling effects (MAPK/AKT anti-apoptosis, PI3K/AKT in CAF crosstalk, NF-κB activation) remains largely unknown, and whether catalytic activity versus protein–protein interactions drive its non-matrix functions (e.g., Smad2 stabilization) is unresolved.
  • Comprehensive substrate profiling (e.g., degradomics) has not been performed
  • Full-length MMP11 structure including prodomain and hemopexin domain is unavailable
  • In vivo relevance of many cancer cell line findings awaits validation in conditional knockout or knock-in models

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 5 GO:0016787 hydrolase activity 3
Localization
GO:0005576 extracellular region 2 GO:0031012 extracellular matrix 2
Pathway
R-HSA-1643685 Disease 6 R-HSA-162582 Signal Transduction 5 R-HSA-1474244 Extracellular matrix organization 2 R-HSA-1266738 Developmental Biology 1
Partners
COL6A1GLI1KDM6ASMAD2STAT3

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 Crystal structure of MMP-11 (stromelysin-3) catalytic domain complexed with a phosphinic inhibitor reveals that its S1' pocket forms a tunnel running through the enzyme (not a simple pocket), distinct from other MMPs. The structure also shows a water molecule interacting with the inhibitor phosphinyl group and the Pro residue of the Met-turn, suggesting how the proteolytic intermediate is stabilized, and a hydrogen bond between the methyl of the phosphinic group and the carbonyl of Ala182 mimicking the amide of the cleaved peptide bond. X-ray crystallography of catalytic domain–inhibitor complex Journal of molecular biology High 11254383
1999 MMP-11 (stromelysin-3) gene inactivation in mice leads to significantly enhanced neointima formation after vascular injury, with more abundant alpha-actin-positive and CD45-positive cells in the intima and more extensive degradation of the internal elastic lamina, indicating that MMP-11 normally restrains smooth muscle cell and leukocyte accumulation and limits elastin degradation after injury. MMP-11 knockout mouse model with vascular injury (electric injury of femoral artery), immunocytochemistry, morphometric analysis Arteriosclerosis, thrombosis, and vascular biology High 10591662
2003 Active (wild-type) MMP-11/ST3 enzymatic activity promotes survival of MCF-7 breast cancer cells in 3D Matrigel culture by suppressing apoptosis, accompanied by activation of p42/p44 MAPK and AKT pathways. A catalytically inactive mutant (ST3cat-) did not confer this survival advantage, and the broad-spectrum MMP inhibitor batimastat reversed the effect, demonstrating that ST3 catalytic activity is required. Stable transfection of wild-type vs. catalytically inactive ST3 in MCF-7 cells, 3D Matrigel culture, FACS, TUNEL, batimastat inhibition, western blot for MAPK/AKT International journal of cancer High 12845673
2011 Gli1 overexpression in ERα-negative breast cancer cells (MDA-MB-231) increases MMP-11 expression and enhances cell migration and invasion; silencing MMP-11 in Gli1-overexpressing cells abrogates the Gli1-induced migration and invasion, placing MMP-11 downstream of Gli1 in this pathway. Gli1 overexpression/RNAi, MMP-11 siRNA rescue experiment, migration/invasion assays, in vivo experimental metastasis assay Clinical & experimental metastasis Medium 21442356
2017 MMP-11 overexpression in oral squamous cell carcinoma cells increases cell migration through activation of the FAK/Src kinase pathway, placing MMP-11 upstream of FAK/Src signaling in promoting cell motility. MMP-11 overexpression in OSCC cell lines, scratch/migration assay, western blot for phospho-FAK and phospho-Src Oncotarget Medium 28427180
2018 IGF-1 induces MMP-11 expression in gastric cancer SGC-7901 cells via sequential activation of IGF-1R → JAK1 → STAT3 phosphorylation; inhibition of IGF-1R (NT157), JAK1 (piceatannol), or STAT3 (siRNA) each reduce IGF-1-induced MMP-11 upregulation, and MMP-11 induction mediates IGF-1-driven proliferation and invasion. Western blot for phospho-STAT3/JAK1/IGF-1R, pharmacological inhibitors (NT157, piceatannol), STAT3 siRNA, proliferation/invasion assays Oncology letters Medium 29731870
2018 MMP-11 promotes proliferation and migration of papillary thyroid cancer cells (K1 and BCPAP) by activating NF-κB signaling: MMP-11 manipulation alters phospho-p65 levels while p65 knockdown does not affect MMP-11 expression, placing MMP-11 upstream of NF-κB p65. Cyclin D1 changes are consistent with MMP-11 expression, potentially explaining proliferative effects. MMP-11 plasmid overexpression and siRNA knockdown, western blot for phospho-p65 and cyclin D1, p65 siRNA, Transwell migration assay Journal of cellular biochemistry Medium 30171715
2021 MMP11 overexpression in macrophages (but not in tumor cells or fibroblasts) promotes migration of HER2-positive breast cancer cells and monocyte recruitment. The mechanism involves CCL2 secretion from MMP11-overexpressing macrophages, which activates the MAPK pathway via CCR2 in breast cancer cells, leading to MMP9 upregulation and enhanced cancer cell migration. MMP11 overexpression in macrophages, co-culture assays, CCL2/CCR2 pathway analysis, MAPK western blot, tube formation assay Laboratory investigation Medium 34775491
2021 MMP11 inhibits ubiquitin–proteasome-mediated degradation of Smad2 protein (in the TGF-β signaling pathway), thereby stabilizing Smad2 and promoting breast cancer cell proliferation; MMP11 knockdown decreases Smad2 and Smad3 protein levels and suppresses tumor growth in vivo. Western blot for Smad2/Smad3, ubiquitin-proteasome pathway assay, MMP11 knockdown/overexpression, MTT, colony formation, xenograft Oncology reports Medium 33649832
2022 Androgen signaling, via the transcription factor MafB, induces Mmp11 expression in genital mesenchyme; MMP11 remodels the local extracellular matrix by degrading Collagen VI (ColVI), which leads to fibrillar fibronectin deposition, increased cell contractility and focal adhesion assembly, driving cell migration during external genitalia development. MafB loss-of-function mice lose these ECM remodeling and migratory cell characteristics. MafB knockout mice, androgen treatment, ex vivo organ culture, ColVI immunostaining, fibronectin deposition assay, focal adhesion analysis, recombinant MMP11 iScience High 36465133
2022 A germline gain-of-function variant in MMP11 (p.Pro78Ser) located in the prodomain region (responsible for blocking protease activity) increases tumor cell invasion and proliferation in HCT116 colorectal cancer cells in vitro, suggesting premature or uncontrolled activation of MMP11 enzymatic activity contributes to early colorectal cancer onset. Whole exome sequencing, in silico structural analysis, expression of P78S variant in HCT116 cells, invasion and proliferation assays International journal of cancer Medium 36093604
2024 In pancreatic cancer, cancer cell-derived TGF-β1 activates CAFs via the pSmad2/3 pathway, inducing MMP11 production. CAF-derived MMP11 promotes tumor cell proliferation and invasion through the PI3K/AKT pathway (not primarily by ECM remodeling); MMP11 knockdown in CAFs reduces invasion of PDAC cells, rescued by adding recombinant MMP11, and suppresses tumor growth and liver metastasis in vivo. Co-culture of cancer cells and CAFs, siRNA knockdown of MMP11, recombinant MMP11 rescue, PI3K/AKT western blot, xenograft co-injection model, scRNA-seq, co-immunofluorescence Cancer science High 39639765
2004 MMP-11 expression in mouse fibroblasts (NIH3T3 and primary MEFs) is stimulated more than 2-fold by 48-hour treatment with IL-1β, IL-2, TGF-β, fibronectin, and collagen V, identifying cytokines and extracellular matrix components as inducers of stromal MMP-11 in the context of breast cancer–stroma interactions. Competitive quantitative RT-PCR of fibroblasts treated with cytokines and matrix components, co-culture with breast cancer cell lines BMC cancer Medium 15272933
2020 Gastrin (GAST) promotes gastric cancer cell proliferation, migration and invasion through the STAT3/MMP11 pathway; gain- and loss-of-function analyses show that GAST induces MMP11 expression downstream of STAT3 activation, and miR-30a-3p negatively regulates GAST to suppress this axis. GAST overexpression/knockdown, STAT3 pathway analysis, MMP11 expression measurement, migration/invasion assays OncoTargets and therapy Low 32922036
2023 In pancreatic cancer, SOX4 is aberrantly activated in myofibroblast-like CAFs (myCAFs) and promotes secretion of MMP11, which induces early cancer cell invasion (perineural and microvascular), placing SOX4 as an upstream transcriptional driver of MMP11 in the CAF-cancer cell crosstalk axis. scRNA-seq reanalysis, CAF differentiation trajectory, SOX4/MMP11 expression correlation, functional invasion assays Biochimica et biophysica acta. Molecular basis of disease Low 37633471
2024 MEHP (active metabolite of DEHP) suppresses MMP11 expression in human foreskin fibroblasts by activating PPAR-γ, which upon MEHP binding reduces MMP11 transcription; reduced MMP11 impairs fibroblast migration, contributing to hypospadias pathogenesis. Epigenetic modifications induced by MEHP also participate in MMP11 suppression. RNA sequencing, molecular docking, PPAR-γ activation assay, MMP11 expression by RT-qPCR/western blot, migration assay, epigenetic analysis Ecotoxicology and environmental safety Medium 39236653
2025 KDM6A (a H3K27me3 demethylase) transcriptionally maintains elevated MMP-11 expression in metastatic prostate cancer (LNCaP) cells by demethylating H3K27me3 at the MMP-11 promoter; KDM6A-specific siRNA knockdown reduces MMP-11 protein, and ChIP shows increased H3K27me3 enrichment at the MMP-11 promoter upon KDM6 inhibition with GSK-J4. KDM6 inhibitor (GSK-J4), KDM6A/KDM6B siRNA, RT-qPCR, western blot, chromatin immunoprecipitation (ChIP) for H3K27me3 at MMP-11 promoter Epigenomics High 41212163
1992 The human stromelysin 3 (MMP11/STMY3) gene was mapped to chromosome 22q11.2 by in situ hybridization and somatic cell hybrid analysis, placing it in a distinct chromosomal location from other MMP genes (chromosomes 11 and 16), suggesting MMP11 belongs to a separate MMP subfamily. In situ hybridization, somatic cell hybrid panel analysis Genomics Medium 1639418
2021 Norepinephrine inhibits migration and invasion of human glioblastoma cells (U87 and U251), and this effect is associated with decreased MMP-11 expression as identified by RT2 Profiler PCR Array; MMP-11 silencing alone inhibits glioblastoma cell migration and invasion. β-adrenergic receptor blockade with propranolol partially blunts norepinephrine's suppressive effect in U251 cells. Scratch wound healing assay, Transwell invasion assay, Human Tumor Metastasis RT2 Profiler PCR Array, MMP-11 siRNA knockdown, pharmacological β-AR blockade Brain research Medium 33515535
2023 MMP11+ macrophage-like CAFs (MMP11+ mCAFs) in bladder cancer regulate migration of tip endothelial cells via the WNT5A-MCAM signaling axis and recruit SPP1+ macrophages through CCL11/CCL2, which in turn secrete VEGFA to enhance pro-angiogenic activity. Interferon-associated basal-like tumor cells secrete BMP2, which induces NFE2L3 transcription factor activity specifically in MMP11+ mCAFs, promoting WNT5A expression; BMP2 inhibition suppresses tumor angiogenesis and growth. Single-cell RNA sequencing, cell-cell interaction analysis, transcription factor analysis, mouse BMP2 inhibition experiments Advanced science Medium 40552583

Source papers

Stage 0 corpus · 70 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF. PloS one 170 22768249
2011 Let-7c functions as a metastasis suppressor by targeting MMP11 and PBX3 in colorectal cancer. The Journal of pathology 133 21984339
2019 Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression. International journal of biological sciences 130 31595150
2001 Crystal structure of the stromelysin-3 (MMP-11) catalytic domain complexed with a phosphinic inhibitor mimicking the transition-state. Journal of molecular biology 80 11254383
2007 Expression of matrix metalloproteinases MMP-1, MMP-11 and MMP-19 is correlated with the WHO-grading of human malignant gliomas. Neuroscience research 71 17980449
2003 Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas. Anticancer research 62 14666700
2009 MMP11: a novel target antigen for cancer immunotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research 60 19509157
2011 Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines. Clinical & experimental metastasis 57 21442356
2021 Matrix metalloproteinase 11 (MMP11) in macrophages promotes the migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2-CCR2 signaling. Laboratory investigation; a journal of technical methods and pathology 54 34775491
2021 Circular RNA circ-MMP11 Contributes to Lapatinib Resistance of Breast Cancer Cells by Regulating the miR-153-3p/ANLN Axis. Frontiers in oncology 50 34295807
1999 Accelerated neointima formation after vascular injury in mice with stromelysin-3 (MMP-11) gene inactivation. Arteriosclerosis, thrombosis, and vascular biology 49 10591662
2009 The clinical implications of MMP-11 and CK-20 expression in human breast cancer. Clinica chimica acta; international journal of clinical chemistry 45 19914229
2000 Matrix metalloproteinases-2,-3,-7,-9 and-10, but not MMP-11, are differentially expressed in normal, benign tumorigenic and malignant human keratinocyte cell lines. Biological chemistry 42 10937882
2018 IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway. Oncology letters 40 29731870
2016 Androgen-induced miR-135a acts as a tumor suppressor through downregulating RBAK and MMP11, and mediates resistance to androgen deprivation therapy. Oncotarget 38 27323416
2020 Circ_0000260 Regulates the Development and Deterioration of Gastric Adenocarcinoma with Cisplatin Resistance by Upregulating MMP11 via Targeting MiR-129-5p. Cancer management and research 37 33122949
1999 Stromelysin-3 (ST-3): immunohistochemical characterization of the matrix metalloproteinase (MMP)-11 in benign and malignant skin tumours and other skin disorders. Clinical and experimental dermatology 37 10233668
2017 MMP-11 promoted the oral cancer migration and Fak/Src activation. Oncotarget 35 28427180
2014 Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. Journal of translational medicine 34 24564996
2021 MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein. Oncology reports 33 33649832
2013 Cytokines related to MMP-11 expression by inflammatory cells and breast cancer metastasis. Oncoimmunology 33 23762791
2013 Knockdown of MMP11 inhibits proliferation and invasion of gastric cancer cells. International journal of immunopathology and pharmacology 32 23755751
2018 MMP-11 as a biomarker for metastatic breast cancer by immunohistochemical-assisted imaging mass spectrometry. Analytical and bioanalytical chemistry 28 30218127
1992 Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22. Genomics 28 1639418
2021 Diagnostic values of MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 in patients with colorectal cancer. The Journal of international medical research 27 33942633
2016 The downregulation of miR‑125a‑5p functions as a tumor suppressor by directly targeting MMP‑11 in osteosarcoma. Molecular medicine reports 27 27081863
2019 MMP11 expression in intratumoral inflammatory cells in breast cancer. Histopathology 26 31342542
2004 Stimulation of MMP-11 (stromelysin-3) expression in mouse fibroblasts by cytokines, collagen and co-culture with human breast cancer cell lines. BMC cancer 26 15272933
2020 MicroRNA-125b as a tumor suppressor by targeting MMP11 in breast cancer. Thoracic cancer 24 32291953
2003 Active stromelysin-3 (MMP-11) increases MCF-7 survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase. International journal of cancer 21 12845673
2024 Cancer-associated fibroblast-derived MMP11 promotes tumor progression in pancreatic cancer. Cancer science 18 39639765
2021 Norepinephrine inhibits migration and invasion of human glioblastoma cell cultures possibly via MMP-11 inhibition. Brain research 18 33515535
2015 Significance of MMP11 and P14(ARF) expressions in clinical outcomes of patients with laryngeal cancer. International journal of clinical and experimental medicine 18 26629052
2011 Serum levels of MMP-11 correlate with clinical outcome in Chinese patients with advanced gastric adenocarcinoma. BMC cancer 18 21513571
2021 High MMP-11 expression associated with low CD8+ T cells decreases the survival rate in patients with breast cancer. PloS one 14 34038440
2023 Cancer-associated fibroblasts drive early pancreatic cancer cell invasion via the SOX4/MMP11 signalling axis. Biochimica et biophysica acta. Molecular basis of disease 13 37633471
2021 LINC00221 silencing prevents the progression of hepatocellular carcinoma through let-7a-5p-targeted inhibition of MMP11. Cancer cell international 13 33836753
2020 MMP1 and MMP11 Expression in Peripheral Blood Mononuclear Cells upon Their Interaction with Breast Cancer Cells and Fibroblasts. International journal of molecular sciences 13 33396463
2022 Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice. iScience 12 36465133
2020 Dysregulation of MiR-30a-3p/Gastrin Enhances Tumor Growth and Invasion throughSTAT3/MMP11 Pathway in Gastric Cancer. OncoTargets and therapy 12 32922036
2020 LncRNA CTBP1-AS2 Facilitates Gastric Cancer Progression via Regulating the miR-139-3p/MMP11 Axis. OncoTargets and therapy 11 33204108
2018 HMGA1 and MMP-11 Are Overexpressed in Human Non-melanoma Skin Cancer. Anticancer research 11 29374701
2023 MMP11 is associated with the immune response and immune microenvironment in EGFR-mutant lung adenocarcinoma. Frontiers in oncology 10 36756152
2023 MMP11 and MMP14 contribute to the interaction between castration-resistant prostate cancer and adipocytes. American journal of cancer research 9 38187060
2019 miR-125a-3p suppresses the growth and progression of papillary thyroid carcinoma cell by targeting MMP11. Journal of cellular biochemistry 9 31489990
2022 Germline gain-of-function MMP11 variant results in an aggressive form of colorectal cancer. International journal of cancer 8 36093604
2025 Single-Cell RNA Sequencing Identifies MMP11+ Cancer-Associated Fibroblasts as Drivers of Angiogenesis and Bladder Cancer Progression. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 7 40552583
2022 Mechanism of miR-340-5p in laryngeal cancer cell proliferation and invasion through the lncRNA NEAT1/MMP11 axis. Pathology, research and practice 7 35700579
2019 Epigenetic Status of The Human MMP11 Gene Promoter is Altered in Patellar Tendinopathy. Journal of sports science & medicine 7 30787663
2018 MMP-11 promotes papillary thyroid cell proliferation and invasion via the NF-κB pathway. Journal of cellular biochemistry 7 30171715
2014 MMP-11 and VEGF-C expression correlate with clinical features of colorectal adenocarcinoma. International journal of clinical and experimental medicine 7 25356153
2012 Expression of MMP-2, MMP-9 and MMP-11 in dermatofibroma and dermatofibrosarcoma protuberans. The Kaohsiung journal of medical sciences 7 23089320
2010 Association between polymorphisms of matrix metalloproteinase 11 (MMP-11) and Kawasaki disease in the Korean population. Life sciences 7 20230842
2008 Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas. World journal of surgical oncology 7 18954439
2024 MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key points in understanding the mechanisms and celerity of tumor dissemination. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 6 38527983
2025 Diagnostic accuracy of serum biomarkers MMP11 and SPP1 in non-small cell lung cancer: an analysis of sensitivity, specificity, and area under the curve. Translational lung cancer research 5 40386736
2022 Quantitative multiplexed analysis of MMP-11 and CD45 in metastatic breast cancer tissues by immunohistochemistry-assisted LA-ICP-MS. Metallomics : integrated biometal science 5 35867868
2019 Comparative analysis of the expression of metalloproteases (MMP-2, MMP-9, MMP-11 and MMP-13) and the tissue inhibitor of metalloprotease 3 (TIMP-3) between previous negative biopsies and radical prostatectomies. Actas urologicas espanolas 5 31899007
2025 AXL-Mediated Drug Resistance in ALK-Rearranged NSCLC Enhanced by GAS6 From Macrophages and MMP11 Positive Fibroblasts. Cancer science 4 39904499
2025 Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanism. Journal of experimental & clinical cancer research : CR 4 40122809
2020 Diagnostic value of Doppler ultrasound parameters combined with MMP-11 in early breast cancer and benign breast diseases. Oncology letters 4 32724341
2023 linc00511 Knockdown Inhibits Lung Cancer Progression by Regulating miR-16-5p/MMP11. Critical reviews in eukaryotic gene expression 2 37602450
2024 Mono-2-ethylhexyl phthalate-induced downregulation of MMP11 in foreskin fibroblasts contributes to the pathogenesis of hypospadias. Ecotoxicology and environmental safety 1 39236653
2026 Expression and Clinical Significance of FOXQ1, MMP11, and CST1 in Colorectal Cancer. Clinical laboratory 0 41670526
2025 RETRACTION: MiR-125a-3p Suppresses the Growth and Progression of Papillary Thyroid Carcinoma Cell by Targeting MMP11. Journal of cellular biochemistry 0 40159300
2025 Association of MMP-11 Genotypes With Colorectal Cancer in Taiwan. In vivo (Athens, Greece) 0 40578973
2025 Elucidating the Genetic Contribution to Nasopharyngeal Carcinoma Risk Through Matrix Metalloproteinase-11 (MMP-11) Genotypic Analysis. Anticancer research 0 41006010
2025 MMP11 predicts colorectal cancer outcomes and its inhibitor RXP03 exerts anti-tumor effects via apoptosis activation. BMC gastroenterology 0 41057770
2025 Epigenetic regulation of MMP-11 and -16 expression in human prostate cancer: the role of KDM6A. Epigenomics 0 41212163
2025 MMP11 promotes immune escape in esophageal carcinoma cells via the PD-L1/c-Myc signaling pathway. Translational oncology 0 41265186