Affinage

MGST3

Glutathione S-transferase 3, mitochondrial · UniProt O14880

Length
152 aa
Mass
16.5 kDa
Annotated
2026-04-28
91 papers in source corpus 18 papers cited in narrative 18 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MGST3 is a membrane-bound MAPEG superfamily enzyme that functions as a glutathione-dependent detoxification catalyst with broad substrate specificity, serving dual roles in eicosanoid metabolism and antioxidant defense against lipid peroxidation. It catalyzes glutathione conjugation of electrophilic substrates including lipid hydroperoxides (5-HPETE peroxidase activity), LTA4 (LTC4 synthase activity), xenobiotics (CDNB, EPNP), and 15-deoxy-Δ12,14-prostaglandin J2 (PMID:9278457, PMID:23785063, PMID:36370807). Transcriptionally regulated by NRF2 and PPARα, MGST3 functions downstream of mutant p53/NRF2 signaling to suppress ferroptosis by detoxifying lipid peroxides, and its loss in colonic epithelial cells activates glutathione metabolic pathways and promotes tumorigenic transformation (PMID:22496397, PMID:38354236, PMID:41858713). MGST3 additionally modulates α-synuclein extracellular transport via the UBL3 interaction in an antioxidant-dependent manner, and regulates BACE1 translation through an RGS4–AKT signaling axis to influence amyloidogenesis (PMID:39000460, PMID:38971310).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1997 High

    The fundamental question of MGST3's enzymatic identity was answered: recombinant MGST3 possesses both glutathione-dependent peroxidase activity (reducing 5-HPETE) and LTC4 synthase activity (conjugating LTA4 with glutathione), establishing it as a bifunctional membrane-bound enzyme in eicosanoid metabolism.

    Evidence Baculovirus expression in Sf9 insect cells with direct enzymatic activity assays using purified substrates

    PMID:9278457

    Open questions at the time
    • No crystal structure of MGST3 itself was determined
    • Endogenous cellular contribution versus other MAPEG enzymes not delineated
    • Kinetic parameters for LTA4 substrate not fully characterized
  2. 2002 Medium

    The tissue-level role of MGST3 in the nervous system was clarified: broad neuronal expression throughout rat brain without induction by LPS indicated a constitutive neuroprotective/detoxification function rather than participation in acute inflammatory leukotriene synthesis.

    Evidence In situ hybridization histochemistry and RT-PCR in rat brain; in vivo LPS challenge

    PMID:12435427

    Open questions at the time
    • No loss-of-function study in neurons to confirm neuroprotective function
    • Specific neuronal substrates not identified
    • Protein-level confirmation in human brain not performed
  3. 2005 Medium

    The functional distinction between MGST3 and LTC4 synthase in inflammatory responses was established: LPS selectively upregulates LTC4S but not MGST3 in multiple rat tissues, confirming MGST3 is not part of the acute inflammatory cysteinyl leukotriene arm.

    Evidence In vivo LPS injection in rats with mRNA (Northern blot/RT-PCR) and protein (immunoblot) quantification

    PMID:15619010

    Open questions at the time
    • Whether MGST3 responds to other non-LPS inflammatory stimuli was not tested
    • Mechanism of differential transcriptional regulation between MGST3 and LTC4S not identified
  4. 2007 Medium

    Structural studies on the MAPEG family member LTC4S revealed that MGST3 possesses broader substrate specificity than LTC4S, conjugating glutathione to xenobiotics in addition to LTA4, placing MGST3 as a more versatile detoxification enzyme within the family.

    Evidence X-ray crystallography of LTC4S at 3.3 Å with comparative biochemical analysis of MAPEG members

    PMID:17632548

    Open questions at the time
    • MGST3 structure not directly solved
    • Structural basis for MGST3's broader specificity inferred rather than demonstrated
  5. 2013 High

    Two key advances defined MGST3 regulation and catalytic breadth: its transcription in liver is controlled by PPARα and NRF2 (demonstrated by null-mouse epistasis), and recombinant cynomolgus MGST3 confirmed glutathione S-transferase activity toward model xenobiotic substrates CDNB and EPNP.

    Evidence Chemical activator studies in PPARα-null and Nrf2-null mice; recombinant protein enzymatic assays in E. coli

    PMID:22496397 PMID:23785063

    Open questions at the time
    • Whether PPARα and NRF2 act directly on the MGST3 promoter or indirectly was not resolved
    • Full substrate specificity profile for human MGST3 not determined
  6. 2019 Medium

    The evolutionary conservation of MGST3's membrane-protective peroxidase function was demonstrated: human MGST3 rescued heat, cold, and lipid peroxidation sensitivity phenotypes of a cyanobacterial MAPEG deletion mutant, confirming an ancient role in membrane lipid protection.

    Evidence Cross-kingdom complementation of Synechocystis Δsll1147 with synthetic human MGST3; stress survival and lipid peroxidation assays; E. coli heterologous expression

    PMID:31681188

    Open questions at the time
    • Whether the rescue reflects peroxidase activity specifically or a broader detoxification capacity was not resolved
    • Single-lab study without independent replication
  7. 2022 High

    A new endogenous substrate was identified: MGST3 is required for biosynthesis of 15dPGJ2-glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells, expanding MGST3's role from xenobiotic detoxification to prostaglandin metabolism during inflammation.

    Evidence LC-MS/MS lipidomics in RAW264.7 cells, primary macrophages, and human mast cells with genetic/pharmacological modulation of MGST3

    PMID:36370807

    Open questions at the time
    • Physiological consequences of 15dPGJ2-GS conjugation (signaling vs. clearance) not established
    • Relative contribution of MGST3 versus other GSTs to 15dPGJ2 conjugation in vivo not quantified
  8. 2023 Medium

    An unexpected non-enzymatic function emerged: MGST3 positively regulates the UBL3–α-synuclein interaction, with MGST3 silencing reducing their co-localization and interaction, suggesting a role in α-synuclein sorting.

    Evidence RNA interference; split Gaussia luciferase complementation assay; immunocytochemistry

    PMID:37760932

    Open questions at the time
    • Whether the effect requires MGST3 catalytic activity or is structural/scaffolding was not determined
    • Single-lab findings; mechanism linking MGST3 to UBL3–α-syn interaction unknown
  9. 2024 Medium

    Multiple 2024 studies expanded MGST3's biological roles in three directions: (1) MGST3 suppresses ferroptosis downstream of mutant p53/NRF2 in triple-negative breast cancer via lipid peroxide detoxification; (2) MGST3 modulates BACE1 translation and amyloidogenesis through an RGS4–AKT signaling axis; (3) MGST3 loss in colonic epithelial cells activates glutathione metabolism and drives tumorigenic transformation; and (4) MGST3 mediates α-synuclein extracellular export via UBL3 in an antioxidant-dependent manner.

    Evidence Autochthonous TNBC mouse model with inducible p53 deletion and single-cell transcriptomics; RNAi with RNA-seq and pharmacological AKT inhibition in cell lines; knockdown in normal colonic epithelial cells with proliferation/EMT assays; MGST3 overexpression with luciferase complementation, H2O2 challenge, and extracellular vesicle analysis

    PMID:38354236 PMID:38971310 PMID:39000460 PMID:41858713

    Open questions at the time
    • MGST3 knockout animal models for any of these phenotypes have not been reported
    • Whether the RGS4–AKT–BACE1 pathway operates in neurons in vivo is unknown
    • Tumor suppressor role based on single cell line without in vivo validation
    • Whether ferroptosis suppression and α-synuclein transport involve the same catalytic mechanism is untested
  10. 2025 Medium

    MGST3 was identified as a direct molecular target of the natural product geranyl hydroquinone (GHQ) in neutrophils, with MGST3 required for GHQ's analgesic and antioxidative effects in rheumatoid arthritis models, establishing MGST3 as a druggable target in inflammatory pain.

    Evidence LC-MS/MS protein-ligand binding; in vitro neutrophil assays; collagen-induced arthritis mouse model with MGST3 requirement validation

    PMID:40147153

    Open questions at the time
    • Binding site on MGST3 not structurally mapped
    • Whether GHQ activates or inhibits MGST3 enzymatic activity not fully characterized
    • Single-lab finding awaiting independent confirmation

Open questions

Synthesis pass · forward-looking unresolved questions
  • No crystal or cryo-EM structure of MGST3 has been reported, and no MGST3 knockout mouse phenotype is published, leaving the relative in vivo contributions of MGST3's peroxidase, LTC4 synthase, xenobiotic transferase, and non-enzymatic scaffolding activities undefined.
  • No MGST3 protein structure available
  • No MGST3 knockout or conditional knockout mouse reported
  • Whether MGST3's effects on α-synuclein and BACE1 require catalytic activity is unknown
  • Relative physiological importance of each substrate class in vivo is unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016209 antioxidant activity 3 GO:0016491 oxidoreductase activity 3 GO:0016740 transferase activity 3
Localization
GO:0005783 endoplasmic reticulum 2
Pathway
R-HSA-1430728 Metabolism 4 R-HSA-8953897 Cellular responses to stimuli 3 R-HSA-5357801 Programmed Cell Death 1
Partners
RGS4UBL3

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 MGST3 (microsomal glutathione S-transferase III) was identified as a novel enzyme with glutathione-dependent peroxidase activity (reducing 5-HPETE to 5-HETE) and LTC4 synthase activity (conjugating LTA4 with glutathione to produce LTC4), with an apparent Km of 21 µM for 5-HPETE, establishing it as a bifunctional membrane-bound enzyme in eicosanoid metabolism. Baculovirus insect cell (Sf9) expression system; enzymatic activity assays with 5-HPETE and LTA4 substrates The Journal of biological chemistry High 9278457
2007 Crystal structure of LTC4S (a close MAPEG family member) revealed that MGST2 and MGST3, unlike LTC4S, conjugate glutathione to xenobiotics in addition to LTA4, distinguishing their broader substrate specificity from LTC4S's high substrate specificity. X-ray crystallography at 3.3 Å resolution; comparative biochemical analysis Nature Medium 17632548
2005 MGST3 mRNA expression levels showed significant correlation with cellular resistance to artesunate in NCI cancer cell lines, suggesting that MGST3-mediated glutathione conjugation contributes to tumor resistance to this endoperoxide-containing drug. Microarray-based mRNA expression analysis correlated with drug sensitivity across 55 NCI cell lines In vivo (Athens, Greece) Low 15796179
2002 MGST3 mRNA is broadly expressed throughout the rat nervous system, predominantly in neurons, with strong signal in hippocampal formation, cranial nerve nuclei, motoneurons, and dorsal root ganglia, and the expression does not respond to LPS, suggesting a role in metabolic detoxification and neuroprotection rather than proinflammatory eicosanoid biosynthesis. In situ hybridization histochemistry and RT-PCR in rat brain sections; LPS administration in vivo Neuroscience Medium 12435427
2005 LPS administration in rats selectively upregulates LTC4 synthase but not MGST2 or MGST3 mRNA in heart, brain, adrenal glands, and liver, indicating that MGST3 does not participate in the acute proinflammatory LPS response and is functionally distinct from LTC4S in this context. In vivo LPS injection in rats; mRNA quantification by Northern blot/RT-PCR; protein quantification by immunoblot Cellular and molecular life sciences : CMLS Medium 15619010
2013 MGST3 expression in liver is regulated by PPARα and Nrf2 transcription factors, as demonstrated by chemical activator studies in transcription factor-null mice showing that Mgst3 mRNA induction by PPARα activators and Nrf2 activators is abolished in the respective null mice. In vivo chemical activator administration in wild-type and transcription factor-null mice; mRNA quantification Drug metabolism and disposition: the biological fate of chemicals High 22496397
2013 Cynomolgus MGST3 protein, heterologously expressed in E. coli, conjugates both 1-chloro-2,4-dinitrobenzene (CDNB) and 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP) with glutathione, confirming glutathione S-transferase catalytic activity similar to human MGST3. Heterologous expression in E. coli; enzymatic activity assays with CDNB and EPNP substrates Drug metabolism and disposition: the biological fate of chemicals High 23785063
2011 In LLC-PK1 renal proximal tubular cells, aristolochic acid I (AAI) selectively upregulates FLAP and MGST3 expression in a concentration-dependent and ERK-dependent manner, and MEK/ERK inhibitor U0126 reverses AAI-induced apoptosis while reducing MGST3 and FLAP expression, placing MGST3 downstream of the MEK/ERK pathway in AAI-induced cysteinyl leukotriene synthesis and apoptosis. In vitro cell treatment; RT-PCR, immunoblot; pharmacological inhibition with MK866 (FLAP inhibitor) and U0126 (MEK/ERK inhibitor); cysteinyl leukotriene measurement Toxicology Medium 21658425
2022 MGST3 is essential for the biosynthesis of 15dPGJ2-glutathione (15dPGJ2-GS) and 15dPGJ2-cysteine (15dPGJ2-Cys) conjugates in RAW264.7 macrophages and human mast cells following inflammatory stimulation, establishing MGST3 as the enzyme responsible for glutathione conjugation of 15-deoxy-Δ12,14-prostaglandin J2. LC-MS/MS lipidomics in RAW264.7 cells and primary macrophages/human mast cells; genetic/pharmacological modulation of MGST3; IgE-receptor stimulation Journal of lipid research High 36370807
2024 MGST3 knockdown in cell lines reduced BACE1 protein levels and amyloidogenesis through a translational (not transcriptional) mechanism involving RGS4 and downstream AKT signaling; RGS4 was identified as a target gene of MGST3, and AKT inhibition abolished the MGST3/RGS4 effect on BACE1, placing MGST3 in a pathway: MGST3 → RGS4 → AKT → BACE1 translation → amyloid production. RNA interference knockdown in cell lines; RNA-seq; Western blot for BACE1, phospho-AKT; pharmacological AKT inhibition; RGS4 silencing epistasis The Journal of biological chemistry Medium 38971310
2024 Mutant p53 protects triple-negative breast cancer cells from ferroptosis through NRF2-dependent upregulation of MGST3 (and PRDX6), which encodes a glutathione-dependent lipid peroxidase; deletion of mutant p53 triggers ferroptosis in vivo and ferroptosis inhibitors reverse this effect, placing MGST3 downstream of mutant p53/NRF2 as a ferroptosis suppressor. Autochthonous somatic TNBC mouse model with inducible genetic deletion of mutant p53; single-cell transcriptomics; in vivo ferroptosis assays; ferroptosis inhibitor rescue experiments Science advances High 38354236
2023 Silencing MGST3 by RNA interference significantly downregulates the interaction between UBL3 and α-synuclein as measured by split Gaussia luciferase complementation assay, and immunocytochemistry confirmed reduced co-localization of UBL3 and α-syn upon MGST3 silencing, placing MGST3 as a positive regulator of the UBL3–α-syn interaction. RNA interference; split Gaussia luciferase complementation assay; immunocytochemistry Biomedicines Medium 37760932
2024 MGST3 overexpression upregulates the interaction between α-synuclein and UBL3 and promotes translocation of intracellular α-syn to the extracellular space via small extracellular vesicles; this effect is mediated through MGST3's antioxidant function and is abolished under excess oxidative stress (H2O2 treatment), without altering expression levels of α-syn or UBL3. MGST3 overexpression; split Gaussia luciferase complementation assay; immunocytochemistry; Western blot; RT-qPCR; oxidative stress induction with H2O2 International journal of molecular sciences Medium 39000460
2019 Human MGST3 (synthetic gene adapted to cyanobacterial codon usage) rescues the heat, cold, and lipid peroxidation resistance phenotypes of a cyanobacterial MAPEG2-like deletion mutant (Δsll1147) in Synechocystis PCC 6803, and also confers increased heat and n-tBOOH tolerance in E. coli, demonstrating functional conservation of MGST3 peroxidase/membrane-protective activity across evolution. Complementation of cyanobacterial deletion mutant with synthetic human MGST3 gene; stress survival assays; lipid peroxidation measurement; E. coli heterologous expression Frontiers in microbiology Medium 31681188
2014 MGST3 was identified as a candidate gene associated with hippocampus size variation in both mouse (BXD recombinant inbred population) and human GWAS data, with systems-level co-expression analysis linking MGST3 to a network of genes involved in neurodegenerative disorders including Alzheimer's disease. Cross-species comparative QTL/GWAS analysis; BXD recombinant inbred mouse population; co-expression network analysis BMC genomics Low 25280473
2016 Local expression QTL (eQTL) analyses in BXD mice confirmed that variation in Mgst3 expression in brain and liver is modulated by sequence variants within or near the Mgst3 gene locus (cis-eQTL), as validated by allele-specific assays. BXD recombinant inbred population linkage analysis; allele-specific expression assays PloS one Medium 26829228
2024 MGST3 knockdown in normal colonic epithelial cells activated glutathione metabolic pathways and induced tumorigenic transformation characterized by accelerated proliferation and suppression of epithelial-mesenchymal transition (EMT), establishing MGST3 as a tumor suppressor in colon carcinogenesis. Gene knockdown in normal human colonic epithelial cells; proliferation assays; EMT marker analysis; RNA-sequencing Molecular and clinical oncology Medium 41858713
2025 Geranyl hydroquinone (GHQ) directly binds to MGST3 in neutrophils as shown by LC-MS/MS and biochemical analyses, and in vitro and in vivo evidence demonstrates that the analgesic and antioxidative effects of GHQ in rheumatoid arthritis require MGST3, identifying MGST3 as a direct molecular target mediating anti-inflammatory and antioxidant effects in neutrophils. LC-MS/MS protein-ligand binding analysis; in vitro neutrophil assays; in vivo CIA mouse model; MGST3 requirement validation Redox biology Medium 40147153

Source papers

Stage 0 corpus · 91 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Analysis of the glutathione S-transferase (GST) gene family. Human genomics 265 15607001
2009 Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre. Mutation research 217 19383551
2012 Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice. Drug metabolism and disposition: the biological fate of chemicals 212 22496397
2006 Therapeutic options for 5-lipoxygenase inhibitors. Pharmacology & therapeutics 195 16837050
2011 Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents. Drug metabolism reviews 152 21495793
1997 Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. The Journal of biological chemistry 127 9278457
2007 Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature 115 17632548
1988 Characterization and heterospecific expression of cDNA clones of genes in the maize GSH S-transferase multigene family. Nucleic acids research 81 3277162
2018 Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid. Diabetes 61 29549163
2001 Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. European journal of biochemistry 61 11322876
1986 Cloning and expression of a cDNA encoding a maize glutathione-S-transferase in E. coli. Nucleic acids research 53 3532034
2021 Oxidative Stress in Dairy Cows: Insights into the Mechanistic Mode of Actions and Mitigating Strategies. Antioxidants (Basel, Switzerland) 52 34943022
2012 Expression of target genes of nuclear factor E2-related factor 2 in the liver of dairy cows in the transition period and at different stages of lactation. Journal of dairy science 50 23245956
2015 Soyabean glycinin depresses intestinal growth and function in juvenile Jian carp (Cyprinus carpio var Jian): protective effects of glutamine. The British journal of nutrition 49 26349522
1997 Cloning, sequencing, crystallization and X-ray structure of glutathione S-transferase-III from Zea mays var. mutin: a leading enzyme in detoxification of maize herbicides. Journal of molecular biology 49 9417936
2008 Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat. Toxicology and applied pharmacology 47 18620719
2005 Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate. In vivo (Athens, Greece) 47 15796179
2003 Leukotriene C(4) synthase. Prostaglandins, leukotrienes, and essential fatty acids 46 12895593
2002 Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes. Prostaglandins & other lipid mediators 46 12432940
2014 Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease. BMC genomics 38 25280473
1993 Partial Characterization of Glutathione S-Transferase Isozymes Induced by the Herbicide Safener Benoxacor in Maize. Plant physiology 38 12231867
1987 Purification and characterization of glutathione S-transferases in human kidney. Clinica chimica acta; international journal of clinical chemistry 35 3113772
2020 A Novel Long Non-coding RNA, MSTRG.51053.2 Regulates Cisplatin Resistance by Sponging the miR-432-5p in Non-small Cell Lung Cancer Cells. Frontiers in oncology 34 32158694
2013 RNA-sequencing quantification of hepatic ontogeny and tissue distribution of mRNAs of phase II enzymes in mice. Drug metabolism and disposition: the biological fate of chemicals 34 23382457
2013 Unique transcriptional profile of sustained ligand-activated preconditioning in pre- and post-ischemic myocardium. PloS one 34 23991079
2011 Cloning of a novel glutathione S-transferase 3 (GST3) gene and expressionanalysis in pearl oyster, Pinctada martensii. Fish & shellfish immunology 34 21807100
2005 Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis. Cellular and molecular life sciences : CMLS 33 15619010
2024 Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo. Science advances 32 38354236
2018 Candidate Biomarkers for Oral Squamous Cell Carcinoma: Differential Expression of Oxidative Stress-Related Genes. Asian Pacific journal of cancer prevention : APJCP 32 29802697
2017 Global Proteome Changes in the Rat Diaphragm Induced by Endurance Exercise Training. PloS one 32 28135290
2017 A Comparative Study on Antioxidant System in Fish Hepatopancreas and Intestine Affected by Choline Deficiency: Different Change Patterns of Varied Antioxidant Enzyme Genes and Nrf2 Signaling Factors. PloS one 31 28099509
2013 Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice. Toxicology and applied pharmacology 29 24240088
2011 Cysteinyl leukotrienes synthesis is involved in aristolochic acid I-induced apoptosis in renal proximal tubular epithelial cells. Toxicology 29 21658425
2007 Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes. Carcinogenesis 28 17984112
2018 Sodium butyrate improves antioxidant stability in sub-acute ruminal acidosis in dairy goats. BMC veterinary research 27 30200953
2016 Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated. Oncotarget 27 27206673
2018 RNA-Seq Meta-analysis identifies genes in skeletal muscle associated with gain and intake across a multi-season study of crossbred beef steers. BMC genomics 23 29866053
2022 Fatty acid metabolism-related genes are associated with flavor-presenting aldehydes in Chinese local chicken. Frontiers in genetics 22 36035160
1993 Sex-dependent expression of class pi glutathione S-transferase during chemical hepatocarcinogenesis in B6C3F1 mice. Carcinogenesis 22 8453732
2020 Alterations in DNA methylation profiles in cancellous bone of postmenopausal women with osteoporosis. FEBS open bio 19 32496000
2013 Characterization of microsomal glutathione S-transferases MGST1, MGST2, and MGST3 in cynomolgus macaque. Drug metabolism and disposition: the biological fate of chemicals 19 23785063
2024 Differential Tissue Abundance of Membrane-Bound Drug Metabolizing Enzymes and Transporter Proteins by Global Proteomics. Drug metabolism and disposition: the biological fate of chemicals 18 38641346
2019 From Cyanobacteria to Human, MAPEG-Type Glutathione-S-Transferases Operate in Cell Tolerance to Heat, Cold, and Lipid Peroxidation. Frontiers in microbiology 18 31681188
2014 PmMGST3, a novel microsomal glutathione S-transferase gene in the dinoflagellate Prorocentrum minimum, is a potential biomarker of oxidative stress. Gene 18 24858638
2013 Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function. Free radical biology & medicine 18 23688726
2015 Transcriptional and biochemical markers in transplanted Perca flavescens to characterize cadmium- and copper-induced oxidative stress in the field. Aquatic toxicology (Amsterdam, Netherlands) 17 25770975
2009 Whole genome survey of the glutathione transferase family in the brown algal model Ectocarpus siliculosus. Marine genomics 17 21798165
2008 Molecular cloning, phylogenetic analysis and expression of a MAPEG superfamily gene from the pufferfish Takifugu obscurus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 17 18832047
2003 Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians. Human genetics 17 12898215
2016 The Genetic Architecture of Murine Glutathione Transferases. PloS one 15 26829228
2007 Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats. The Journal of surgical research 15 17397868
2023 Alpha-class glutathione S-transferases involved in the detoxification of aflatoxin B1 in ducklings. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 12 36813151
2014 Molecular cloning, characterization and positively selected sites of the glutathione S-transferase family from Locusta migratoria. PloS one 12 25486043
2013 A comparative study of polyethylene glycol hydrogels derivatized with the RGD peptide and the cell-binding domain of fibronectin. Journal of biomedical materials research. Part A 12 23613303
2022 Single-Cell Transcriptomics of Endothelial Cells in Upper and Lower Human Esophageal Squamous Cell Carcinoma. Current oncology (Toronto, Ont.) 11 36290884
2024 Spatial metabolomics, LC-MS and RNA-Seq reveal the effect of red and white muscle on rabbit meat flavor. Meat science 10 39341018
2022 Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3. Journal of lipid research 10 36370807
2007 Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. Pharmacology 10 17496435
2019 Characterization of the hepatic transcriptome following phenobarbital induction in mice with AIP. Molecular genetics and metabolism 9 30777612
2018 Transcriptomic Profiles of Brain Provide Insights into Molecular Mechanism of Feed Conversion Efficiency in Crucian Carp (Carassius auratus). International journal of molecular sciences 9 29538345
2002 Expression of microsomal glutathione S-transferase type 3 mRNA in the rat nervous system. Neuroscience 9 12435427
1996 Lentinan enhances sensitivity of mouse colon 26 tumor to cis-diamminedichloroplatinum (II) and decreases glutathione transferase expression. Japanese journal of cancer research : Gann 9 9045947
2024 Integrative Inducer Intervention and Transcriptomic Analyses Reveal the Metabolism of Paralytic Shellfish Toxins in Azumapecten farreri. Environmental science & technology 8 38578272
2021 Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans. Frontiers in genetics 8 34925446
2018 Antioxydation And Cell Migration Genes Are Identified as Potential Therapeutic Targets in Basal-Like and BRCA1 Mutated Breast Cancer Cell Lines. International journal of medical sciences 8 29333087
2023 UBL3 Interaction with α-Synuclein Is Downregulated by Silencing MGST3. Biomedicines 7 37760932
2022 The metabolic genomic atlas reveals potential drivers and clinically relevant insights into the etiology of esophageal squamous cell carcinoma. Theranostics 7 36168622
2020 RNA-seq analysis of palatal transcriptome changes in all-trans retinoic acid-induced cleft palate of mice. Environmental toxicology and pharmacology 7 32569741
2008 MAPEG expression in mouse embryonic stem cell-derived hepatic tissue system. Stem cells and development 7 18752429
2006 Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats. Biochemical pharmacology 7 17194456
2024 Alpha-Synuclein Interaction with UBL3 Is Upregulated by Microsomal Glutathione S-Transferase 3, Leading to Increased Extracellular Transport of the Alpha-Synuclein under Oxidative Stress. International journal of molecular sciences 6 39000460
2016 Molecular Changes in the Nasal Cavity after N, N-dimethyl-p-toluidine Exposure. Toxicologic pathology 6 27099258
2022 Label-Free Direct Mass Spectrometry Analysis of the Bystander Effects Induced in Chondrocytes by Chondrosarcoma Cells Irradiated with X-rays and Carbon Ions. Frontiers in bioscience (Landmark edition) 5 36224025
2024 Investigating the mechanisms underlying resistance to chemoterapy and to CRISPR-Cas9 in cancer cell lines. Scientific reports 4 38443409
2024 COVID-19 severity gradient differentially dysregulates clinically relevant drug processing genes in nasopharyngeal swab samples. British journal of clinical pharmacology 4 38817198
2024 MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway. The Journal of biological chemistry 4 38971310
2018 Expressions of some antioxidant genes in SH-SY5Y cells treated with β-lapachone, morphine and electromagnetic field. Molecular biology reports 3 29611025
2025 Whole-Genome Sequencing Reveals the Role of Cis-Regulatory Elements and eQTL/sQTL in the Adaptive Selection of Hubei Indigenous Cattle. Animals : an open access journal from MDPI 2 40362117
2012 Search for chromosome rearrangements: new approaches toward discovery of novel translocations in head and neck squamous cell carcinoma. Head & neck 2 22807096
2025 The Primary Cultivation of Oogonial Stem Cells from Black Rockfish (Sebastes schlegelii): Morphology and Transcriptome Landscape. International journal of molecular sciences 1 40725018
2024 Biological sex differences in hepatic response to in utero dimethylbenz(a)anthracene exposure. Reproductive toxicology (Elmsford, N.Y.) 1 38307155
2024 Using Bioinformatics and Machine Learning to Predict the Genetic Characteristics of Ferroptosis-Cuproptosis-Related Genes Associated with Sleep Deprivation. Nature and science of sleep 1 39347483
2024 Hepatic Transcriptomics of Broilers with Low and High Feed Conversion in Response to Caloric Restriction. Metabolites 1 39590861
2026 Downregulation of MGST3 promotes colorectal cancer progression. Molecular and clinical oncology 0 41858713
2026 Comparison of oxidative and techno-functional properties of dark and ordinary muscles in snakehead fish: Insights from multi-omics analysis. Food chemistry 0 42030675
2025 Geranyl hydroquinone alleviates rheumatoid arthritis-associated pain by suppressing neutrophil accumulation, N1 polarization and ROS production in mice. Redox biology 0 40147153
2025 Immune function and transcriptome of hemocytes in northern quahogs Mercenaria mercenaria in response to acute salinity challenges. Fish & shellfish immunology 0 40752840
2025 Molecular mechanisms of ammonia nitrogen tolerance in sea cucumbers (Apostichopus japonicus). Aquatic toxicology (Amsterdam, Netherlands) 0 40886645
2025 Screening of Protein Related to Wool Development and Fineness in Gansu Alpine Fine-Wool Sheep. Animals : an open access journal from MDPI 0 40941372
2024 Identification of selective sweep and associated QTL traits in Iranian Ovis aries and Ovis orientalis populations. Frontiers in genetics 0 39748948
2009 [Effect of concanavalin A on expression of MAPEG mRNA in Balb/c mouse brain]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 0 19504633