Affinage

MEOX1

Homeobox protein MOX-1 · UniProt P50221

Length
254 aa
Mass
28.0 kDa
Annotated
2026-04-28
45 papers in source corpus 24 papers cited in narrative 24 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MEOX1 is a homeodomain transcription factor that governs mesodermal patterning, cell cycle control, and fibrotic remodeling by directly activating or repressing context-specific target gene promoters. During embryonic development, MEOX1 maintains sclerotome rostro-caudal polarity by occupying promoters of Tbx18 and Uncx, specifies endotomal endothelial precursors in the somite, and induces G2 cell-cycle arrest in muscle stem cells through direct repression of CCNB1 (PMID:19520072, PMID:25119043, PMID:28686860). In postnatal tissues, MEOX1 is transcriptionally induced by TGF-β1/Smad2-3 and JUN signaling and drives organ fibrosis by activating downstream targets including Cthrc1, ABHD3/circABHD3, and CTGF in cardiac, hepatic, and pulmonary fibroblasts, while also promoting myocardial hypertrophy through Gata4 activation (PMID:29155983, PMID:41362745, PMID:40100806, PMID:39220862). Homozygous loss-of-function mutations in MEOX1 cause Klippel-Feil syndrome in humans, recapitulating the cervical vertebral fusion phenotype of Meox1-null mice (PMID:23290072).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1992 Medium

    Identification of MEOX1 as a novel homeobox gene expressed in embryonic mesoderm established that a previously unknown transcription factor class operated in somitogenesis and mesodermal regionalization.

    Evidence In situ hybridization and expression analysis across mouse embryonic stages

    PMID:1363541

    Open questions at the time
    • No functional data; expression pattern alone does not prove necessity
    • Transcriptional targets unknown
  2. 2001 Medium

    Demonstrating that the MEOX1 homeodomain physically interacts with PAX1 and PAX3 revealed that MEOX1 functions not only as a DNA-binding factor but also as a protein–protein interaction partner for other developmental transcription factors.

    Evidence Yeast two-hybrid and in vitro binding assays mapping interaction to homeodomain

    PMID:11423130

    Open questions at the time
    • Functional consequence of MEOX1–PAX1/3 interaction on transcription not tested
    • No in vivo validation of interaction
  3. 2009 High

    ChIP showing MEOX1 occupancy at Tbx18 and Uncx promoters, combined with the sclerotome polarity defect in Meox1-null mice, established MEOX1 as a direct transcriptional regulator of sclerotome segmentation genes.

    Evidence Mouse knockout, ChIP, gene expression analysis

    PMID:19520072

    Open questions at the time
    • Whether MEOX1 activates or represses each target not fully dissected
    • Redundancy with MEOX2 at these loci not resolved
  4. 2011 High

    Placing MEOX1 downstream of Hoxa2 via direct promoter binding and genetic epistasis defined MEOX1's position in the branchial arch transcriptional hierarchy, while parallel work showed MEOX1 activates p16 (DNA-binding-dependent) and p21 (DNA-binding-independent), revealing dual mechanistic modes of target regulation.

    Evidence ChIP, promoter mutagenesis, Hoxa2 mutant epistasis; MEOX1 DNA-binding-domain mutants with cell cycle and reporter assays in endothelial cells

    PMID:21245383 PMID:22206000

    Open questions at the time
    • Cofactors enabling DNA-binding-independent p21 activation unidentified
    • Whether the dual mechanism operates in non-endothelial contexts untested
  5. 2013 High

    Discovery that homozygous truncating MEOX1 mutations cause Klippel-Feil syndrome in humans provided direct genotype–phenotype validation, linking the mouse sclerotome polarity function to a human Mendelian disorder.

    Evidence Whole-genome linkage in two families, sequencing, transcript stability analysis in patient cells

    PMID:23290072

    Open questions at the time
    • Penetrance and phenotypic spectrum of heterozygous carriers not characterized
    • Molecular rescue not performed in patient cells
  6. 2014 High

    Lineage tracing in zebrafish revealed that Meox1 specifies the endotome fate within somites, restricting endothelial progenitor numbers and thereby haematopoietic stem cell induction—extending MEOX1 function beyond skeletal patterning to vascular/haematopoietic development.

    Evidence Zebrafish loss-of-function genetics, lineage tracing, live imaging

    PMID:25119043

    Open questions at the time
    • Direct transcriptional targets mediating endotome specification not identified
    • Mammalian conservation of this endotome role unconfirmed
  7. 2017 High

    Identification of CCNB1 as a direct MEOX1-repressed target in muscle stem cells, with loss of MEOX1 causing premature exit from G2 arrest and defective myotome growth, established a cell-cycle gating mechanism for stem cell maintenance.

    Evidence Zebrafish genetics, direct binding assays, clonal cell cycle analysis

    PMID:28686860

    Open questions at the time
    • Whether MEOX1-mediated G2 arrest operates in mammalian satellite cells unknown
    • Chromatin mechanism of CCNB1 repression not resolved
  8. 2018 High

    Demonstration that MEOX1 directly activates the Gata4 promoter to exacerbate cardiac hypertrophy established MEOX1 as a pathological transcriptional driver beyond its developmental roles.

    Evidence ChIP and promoter assays, overexpression/knockdown in TAC and FHCM mouse models with echocardiography

    PMID:29155983

    Open questions at the time
    • Upstream signals inducing MEOX1 in hypertrophic cardiomyocytes not identified
    • Whether MEOX1 directly causes cardiomyocyte hypertrophy or acts through fibroblasts not separated
  9. 2020 Medium

    Showing that TGF-β1 activates MEOX1 transcription through Smad2/3 promoter binding placed MEOX1 within the canonical fibrotic signaling cascade and explained its induction in activated fibroblasts.

    Evidence ChIP-qPCR for Smad2/3 on Meox1 promoter, Smad gain/loss-of-function in human dermal fibroblasts

    PMID:32241049

    Open questions at the time
    • Smad binding sites on MEOX1 promoter not mutagenized
    • Whether other TGF-β superfamily ligands activate MEOX1 untested
  10. 2021 Medium

    Multiple studies extended MEOX1-CCNB1 repression to lung cancer G2 arrest and identified MEOX1-driven SDF-1α/CDC42 signaling in vascular smooth muscle remodeling, demonstrating that MEOX1 operates across diverse postnatal cell types.

    Evidence Chromatin binding/rescue in NSCLC cells; shRNA knockdown with pharmacological epistasis in rat carotid injury model

    PMID:34233723 PMID:34837450

    Open questions at the time
    • MEOX1 binding site on SDF-1α promoter not demonstrated by ChIP
    • Whether CCNB1 repression is the sole anti-proliferative mechanism in cancer unclear
  11. 2024 Medium

    Identification of JUN as a direct upstream activator of MEOX1 via promoter binding, and TGF-β1-NOX4-ROS-Smad as an alternative induction axis, refined understanding of how MEOX1 is transcriptionally activated in pulmonary fibrosis.

    Evidence ChIP for JUN on MEOX1 promoter with pharmacological disruption; fibroblast-specific AAV-shMEOX1 knockdown in bleomycin model with NOX4/ROS/Smad inhibitors

    PMID:39220862 PMID:40780596

    Open questions at the time
    • Relative contributions of JUN vs Smad to MEOX1 induction in vivo not quantified
    • Whether JUN and Smad act on same or distinct MEOX1 promoter elements unclear
  12. 2025 High

    Direct promoter binding studies established Cthrc1, ABHD3, and GLP2R as additional MEOX1 transcriptional targets driving cardiac fibrosis (via Smad2/3 feedback), hepatic fibrosis (via circRNA/m6A/β-catenin), and colorectal tumor suppression (via Hippo/YAP1), respectively, revealing MEOX1's broad target repertoire.

    Evidence ChIP and luciferase assays for each promoter; epistasis rescue experiments; in vivo mouse MI, CCl4/BDL liver, and orthotopic CRC models

    PMID:40100806 PMID:41362745 PMID:41612494

    Open questions at the time
    • Genome-wide MEOX1 cistrome in any single cell type not defined
    • How MEOX1 selects between activation and repression at different targets mechanistically unresolved
  13. 2023 Medium

    Identification of MEOX1 as a Treg-specific transcription factor regulated by IL-2, with functional impact on Treg suppressive capacity, opened an immunological role distinct from its mesenchymal functions.

    Evidence Transcriptomic analysis of 48 CD4+ T cell conditions, epigenetic profiling, siRNA knockdown with Treg suppression assay

    PMID:37559728

    Open questions at the time
    • Direct MEOX1 transcriptional targets in Tregs not identified
    • Whether MEOX1 is required for Treg development or only maintenance unknown
    • In vivo validation in conditional knockout mice lacking

Open questions

Synthesis pass · forward-looking unresolved questions
  • A genome-wide binding map (ChIP-seq/CUT&RUN) for MEOX1 in any primary cell type is still lacking, leaving the full direct target repertoire, the chromatin determinants of context-dependent activation versus repression, and the cofactors mediating DNA-binding-independent gene induction unresolved.
  • No published MEOX1 ChIP-seq or CUT&RUN dataset
  • Structural basis for homeodomain-mediated protein interactions (PAX1/3) unknown
  • Whether MEOX1 isoforms or post-translational modifications regulate its dual activator/repressor function untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 10 GO:0140110 transcription regulator activity 9
Localization
GO:0005634 nucleus 4
Pathway
R-HSA-74160 Gene expression (Transcription) 9 R-HSA-1266738 Developmental Biology 6 R-HSA-1643685 Disease 6 R-HSA-162582 Signal Transduction 4 R-HSA-1640170 Cell Cycle 3
Partners
HOXA2JUNPAX1PAX3SMAD2SMAD3

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 Mox-1 (MEOX1) is a homeodomain transcription factor expressed in posterior embryonic mesoderm at primitive streak stages, presomitic mesoderm, somites, and lateral plate mesoderm in mice, defining a novel homeobox gene subfamily with roles in mesodermal regionalization and somitic differentiation. In situ hybridization, genetic mapping, expression analysis in mouse embryos Development Medium 1363541
1996 Mox-1 protein is first detected in newly formed mesoderm of primitive streak stage mouse embryos (7.5 dpc), earlier than Mox-2 (9.0 dpc), and is also expressed in branchial arches and limbs, indicating distinct developmental roles for Mox-1 and Mox-2. Immunostaining of mouse embryos at multiple developmental stages The International Journal of Developmental Biology Medium 9032023
2001 MEOX1 homeodomain physically interacts with PAX1 and PAX3 transcription factors, with a preference of Mox1 for Pax1 over Pax3; this interaction is mediated through the homeodomain of Mox. Yeast two-hybrid assay and in vitro biochemical binding assays FEBS Letters Medium 11423130
2009 Meox1 loss-of-function in mice disrupts sclerotome rostro-caudal polarity, causing assimilation of the atlas into the basioccipital bone; MEOX1 protein occupies conserved promoter regions of Tbx18 and Uncx transcription factor genes, and Meox1 mutants show altered Tbx18, Uncx, and Bapx1 expression, indicating Meox1 directly regulates these genes to maintain sclerotome polarity. Mouse knockout, chromatin immunoprecipitation (ChIP), gene expression analysis, cell proliferation assays Developmental Biology High 19520072
2011 MEOX1 is a direct transcriptional target of Hoxa2; Hoxa2 binds to the Meox1 proximal promoter via two conserved binding sites required for Hoxa2-dependent activation, and Meox1 can bind DNA sequences recognized by Hoxa2 on its functional target genes, placing Meox1 downstream of Hoxa2 in the branchial arch regulatory network. Chromatin immunoprecipitation (ChIP), promoter reporter assays, genetic epistasis (Hoxa2 mouse mutants), Meox1/Meox2 double mutant analysis Molecular and Cellular Biology High 21245383
2011 MEOX1 activates p21(CIP1/WAF1) and p16(INK4a) expression in vascular endothelial cells and induces cell cycle arrest and senescence; MEOX1 activates p16(INK4a) in a DNA binding-dependent manner, whereas it induces p21(CIP1/WAF1) in a DNA binding-independent manner, distinguishing its mechanism from MEOX2. Overexpression of MEOX1 with DNA-binding domain mutants, reporter assays, cell cycle analysis, senescence assays PLoS One High 22206000
2013 Homozygous frameshift or nonsense truncating mutations in MEOX1 cause isolated Klippel-Feil syndrome in humans, and the resulting complete transcript instability phenocopies the cervical skeletal defect of Meox1 null mice, establishing MEOX1 as the causative gene for this sclerotome polarity defect. Whole-genome linkage mapping, direct sequencing, transcript stability analysis in patient cells American Journal of Human Genetics High 23290072
2014 Meox1 specifies endotomal endothelial precursor cells within the zebrafish somite; loss of meox1 expands the endotome at the expense of muscle precursors and increases the number of endotome-derived cells colonizing the dorsal aorta, leading to increased chemokine-dependent haematopoietic stem cell induction. Zebrafish loss-of-function genetics, lineage tracing, live imaging, epistasis with chemokine signaling Nature High 25119043
2017 Meox1 directly inhibits the cell-cycle checkpoint gene ccnb1 (Cyclin B1), inducing G2 cell-cycle arrest in muscle stem cells; disruption of this G2 arrest by loss of Meox1 causes premature lineage commitment and defective muscle growth during zebrafish myotome development. Zebrafish genetic loss-of-function, direct binding assays, cell cycle analysis, clonal analysis Cell Stem Cell High 28686860
2018 MEOX1 transcriptionally activates Gata4 as a downstream target to accelerate myocardial hypertrophic decompensation; MEOX1 overexpression exacerbated hypertrophic phenotypes while knockdown improved them, and direct Gata4 promoter activation was demonstrated by ChIP and promoter activity assays. Overexpression/knockdown in mice (FHCM and TAC models), digital gene expression profiling, ChIP, promoter activity assays, echocardiography Cardiovascular Research High 29155983
2020 TGF-β1 transcriptionally upregulates MEOX1 expression via Smad2/3 binding to the Meox1 promoter in adult human dermal fibroblasts; MEOX1 promotes fibroblast migration as demonstrated by scratch and Transwell assays. ChIP-qPCR for Smad2/3 on Meox1 promoter, Smad overexpression/siRNA knockdown, transcriptome sequencing, migration assays Zhonghua Shao Shang Za Zhi Medium 32241049
2020 Combined p53 and PTEN deficiency in triple-negative breast cancer activates MEOX1 expression; MEOX1 knockdown abolished TNBC cell proliferation in vitro and tumor growth in vivo, and decreased expression of TYK2, STAT5B, and STAT6, placing MEOX1 downstream of combined p53/PTEN loss and upstream of JAK-STAT signaling. siRNA knockdown (p53/PTEN and MEOX1), RNA-Seq, immunoblotting, in vivo tumor growth assay Journal of Biological Chemistry Medium 32467227
2020 PPARα directly regulates the expression of MEOX1 in cardiomyocytes, and the cardioprotective effects of PPARα gene delivery in doxorubicin-induced cardiotoxicity are abolished by MEOX1 knockdown, placing MEOX1 downstream of PPARα in a cardioprotective pathway. Adeno-associated virus gene delivery, knockdown epistasis, cardiac function assays, in vivo mouse model Frontiers in Pharmacology Medium 33132907
2021 MEOX1 binds to the transcriptional initiation site of CCNB1 and suppresses CCNB1 expression, inducing G2 cell cycle arrest in non-small cell lung cancer cells; CCNB1 overexpression rescues the anti-proliferative effects of MEOX1. Chromatin binding assays, overexpression/knockdown, cell cycle analysis, rescue experiments, in vivo tumor growth Environmental Toxicology Medium 34837450
2021 Meox1 regulates SDF-1α expression in vascular smooth muscle cells via CDC42 activation, which promotes CXCR4 expression on Sca-1+ progenitor cells, facilitating their migration and contribution to neointima formation following vascular injury; Meox1 knockdown abolished these effects. Rat carotid artery balloon injury model, shRNA knockdown, inhibitor studies (AMD3100, ZCL278), immunostaining Stem Cell Research & Therapy Medium 34233723
2023 MEOX1 is expressed specifically in regulatory T (Treg) cells at levels comparable to FOXP3, is upregulated by IL-2, has a permissive epigenetic landscape exclusively in Tregs, and its knockdown profoundly alters downstream gene expression and reduces Treg suppressive capacity. Transcriptomic analysis of 48 human CD4+ T cell conditions, reverse network engineering, epigenetic analysis, siRNA knockdown, Treg suppression assays Frontiers in Immunology Medium 37559728
2024 JUN transcription factor binds the MEOX1 promoter to drive its expression; the natural compound Ailanthone disrupts JUN-promoter interaction, suppressing MEOX1 expression and consequently inhibiting fibroblast activation and endothelial-to-mesenchymal transition induced by TGF-β1 in pulmonary fibrosis. High-throughput screening, direct target binding studies, ChIP showing JUN on MEOX1 promoter, in vitro fibroblast/endothelial assays, bleomycin mouse model Acta Pharmaceutica Sinica B Medium 39220862
2024 MEOX1 promotes myofibroblast apoptosis resistance in pulmonary fibrosis by upregulating RGS4 (G-protein signaling pathway regulatory factor 4) as a direct downstream target; MEOX1 silencing enhanced myofibroblast apoptosis and attenuated fibrosis in mice. Bioinformatics prediction, siRNA knockdown, bleomycin mouse model, apoptosis assays Journal of Cellular Physiology Low 39319990
2025 MEOX1 transcriptionally activates Cthrc1, which promotes downstream Smad2/3 phosphorylation, driving cardiac fibroblast-to-myofibroblast conversion following myocardial infarction; Cthrc1 overexpression abolishes cardioprotective effects of MEOX1 silencing. In vivo mouse MI model, knockdown/overexpression, ChIP/luciferase for Cthrc1 promoter, Western blot for p-Smad2/3, epistasis via Cthrc1 rescue International Journal of Biological Sciences High 41362745
2025 MEOX1 directly binds the promoter of ABHD3 to facilitate its transcription and subsequent circABHD3 circular RNA generation; circABHD3 promotes YTHDF2-dependent m6A-modified YPEL3 mRNA degradation, activating β-catenin signaling and driving hepatic fibrosis. Luciferase reporter assay, ChIP, MeRIP, RIP, RNA pull-down, in vivo mouse models (CCl4, BDL) PLoS Genetics High 40100806
2025 TGF-β1 upregulates MEOX1 expression through the NOX4-ROS-Smad signaling pathway in lung fibroblasts; fibroblast-specific MEOX1 knockdown prevents BLM-induced pulmonary fibrosis and abolishes TGF-β1-induced mitophagy deficiency (via CTGF downregulation) and cellular senescence. RNA-sequencing, AAV-shMEOX1 fibroblast-specific knockdown, in vivo bleomycin model, in vitro fibroblast assays, NOX4/ROS/Smad pathway inhibitors European Journal of Pharmacology Medium 40780596
2025 MEOX1 activates hepatic stellate cells via transcriptional regulation of SERPINE1 (PAI-1), promoting MASH-related liver fibrosis; MEOX1 knockdown suppresses HSC activation, proliferation, and migration. RNA-Seq, AlphaFold/PyMOL structural prediction of protein interaction sites, siRNA knockdown, in vitro HSC activation assays, in vivo MASH mouse model The International Journal of Biological Markers Low 40270091
2026 MEOX1 represses PAX1 transcription in glioblastoma cells, and this MEOX1-PAX1 axis promotes tumor cell proliferation, migration, and invasion while PAX1 expression in GBM cells promotes Treg differentiation from CD4+ T cells. Overexpression/knockdown of MEOX1 and PAX1 in GBM cells, co-culture with CD4+ T cells, flow cytometry for Treg markers Scientific Reports Low 41692908
2026 DNA hypermethylation silences MEOX1 in colorectal cancer; MEOX1 directly binds the GLP2R promoter to activate its transcription, and MEOX1-mediated GLP2R upregulation inhibits YAP1-mediated glycolysis through Hippo signaling, suppressing CRC growth and metastasis. ChIP-qPCR and dual-luciferase assays for MEOX1 binding to GLP2R promoter, MeDIP/MSP for DNA methylation, lentiviral overexpression/knockdown, orthotopic and liver metastasis mouse models Cell & Bioscience Medium 41612494

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 Cell transformation by the superoxide-generating oxidase Mox1. Nature 1215 10485709
1992 Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development (Cambridge, England) 263 1363541
2002 A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population. American journal of medical genetics 240 12116252
2014 Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1. Nature 122 25119043
2017 Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest. Cell stem cell 65 28686860
2013 Mutations in MEOX1, encoding mesenchyme homeobox 1, cause Klippel-Feil anomaly. American journal of human genetics 62 23290072
2011 Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. PloS one 58 22206000
1997 The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin. Differentiation; research in biological diversity 54 9373945
1994 Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. Human molecular genetics 47 7987315
2013 Mutation in MEOX1 gene causes a recessive Klippel-Feil syndrome subtype. BMC genetics 46 24073994
2009 Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Developmental biology 46 19520072
1996 Differential localization of Mox-1 and Mox-2 proteins indicates distinct roles during development. The International journal of developmental biology 40 9032023
2007 A comparative analysis of Meox1 and Meox2 in the developing somites and limbs of the chick embryo. The International journal of developmental biology 34 17939123
2001 Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors. FEBS letters 34 11423130
2018 Meox1 accelerates myocardial hypertrophic decompensation through Gata4. Cardiovascular research 29 29155983
2021 MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell-cycle checkpoint gene CCNB1. Environmental toxicology 25 34837450
2018 Skeletal malformations of Meox1-deficient zebrafish resemble human Klippel-Feil syndrome. Journal of anatomy 23 30277257
2020 Combined p53- and PTEN-deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer. The Journal of biological chemistry 22 32467227
2011 Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2. Molecular and cellular biology 22 21245383
2020 PPARα Ameliorates Doxorubicin-Induced Cardiotoxicity by Reducing Mitochondria-Dependent Apoptosis via Regulating MEOX1. Frontiers in pharmacology 21 33132907
2007 Diaphanospondylodysostosis: six new cases and exclusion of the candidate genes, PAX1 and MEOX1. American journal of medical genetics. Part A 16 17764081
2024 Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation. Acta pharmaceutica Sinica. B 15 39220862
2003 A detailed kinetic study of Mox-1, a plasmid-encoded class C beta-lactamase. FEMS microbiology letters 13 12951239
2014 Crystal structure of Mox-1, a unique plasmid-mediated class C β-lactamase with hydrolytic activity towards moxalactam. Antimicrobial agents and chemotherapy 12 24777102
2022 The role of MEOX1 in non-neoplastic and neoplastic diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 11 36495659
1988 RFLP and mapping of human MOX-1 gene on chromosome 3. Nucleic acids research 10 2902568
2021 Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1α/CXCR4. Stem cell research & therapy 7 34233723
2024 MEOX1 triggers myofibroblast apoptosis resistance, contributing to pulmonary fibrosis in mice. Journal of cellular physiology 6 39319990
2021 Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations. Scientific reports 6 34552174
2024 Unraveling the molecular mechanisms of lymph node metastasis in ovarian cancer: focus on MEOX1. Journal of ovarian research 4 38486335
2023 Identification of the novel FOXP3-dependent Treg cell transcription factor MEOX1 by high-dimensional analysis of human CD4+ T cells. Frontiers in immunology 4 37559728
2018 Silencing of MEOX1 Gene Inhibits Proliferation and Promotes Apoptosis of LNCaP Cells in Prostate Cancer. Cancer biotherapy & radiopharmaceuticals 3 30543460
2017 Data on the involvement of Meox1 in balloon-injury-induced neointima formation of rats. Data in brief 3 29204471
2020 [Mechanism of transcriptional regulation of Meox1 by transforming growth factor β (1) and its effect on cell migration of adult human dermal fibroblasts]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 2 32241049
2026 Meox1 Promotes Cardiac Fibrosis and Pathological Remodeling following Myocardial Infarction through Cthrc1/p-Smad2/3 Signaling. International journal of biological sciences 1 41362745
2025 Organelle stresses and energetic metabolisms promote endothelial-to-mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer's disease. Frontiers in molecular neuroscience 1 40919531
2024 Regulatory Role of Meox1 in Muscle Growth of Sebastes schlegelii. International journal of molecular sciences 1 38732090
2022 The squiggle tail (squig) mutation in mice is associated with a deletion in the mesenchyme homeobox 1 (Meox1) gene. BMC research notes 1 36138442
2026 DNA methylation-mediated silencing of MEOX1 promotes glycolysis and immune evasion in colorectal cancer cells through inhibition of GLP2R transcription. Cell & bioscience 0 41612494
2026 The MEOX1-PAX1 axis coordinately regulates tumor cell malignancy and Treg differentiation in glioblastoma. Scientific reports 0 41692908
2026 Meox1 promotes hepatocellular carcinoma progression potentially via regulation of cell cycle and p21 expression. Cell adhesion & migration 0 42002886
2025 MEOX1-mediated transcriptional regulation of circABHD3 exacerbates hepatic fibrosis through promoting m6A/YTHDF2-dependent YPEL3 mRNA decay to activate β-catenin signaling. PLoS genetics 0 40100806
2025 Identification of MEOX1 as a potential target in metabolic dysfunction-associated steatohepatitis-related liver fibrosis. The International journal of biological markers 0 40270091
2025 Transcription factor MEOX1 accelerates pulmonary fibrosis by regulating mitophagy and senescence. European journal of pharmacology 0 40780596
2025 Role of Meox1 in promoting lung tumor vascularization and impairing CD8+ T cell mediated immunity. Frontiers in oncology 0 40919158