MARVELD2
MARVEL domain-containing protein 2 · UniProt Q8N4S9
Round 2 refusal
Audit flag: rerun needed
- Length
- 558 aa
- Mass
- 64.2 kDa
- Annotated
- 2026-04-28
100 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic findings about MARVELD2 in the available literature (corpus appears contaminated with off-target papers).
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 100 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1992 | Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits. | The EMBO journal | 374 | 1361170 |
| 2008 | Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies. | Nature structural & molecular biology | 319 | 19011634 |
| 2006 | The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions. | Nature cell biology | 253 | 16980959 |
| 2006 | Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. | Molecular cell | 226 | 16973440 |
| 2009 | The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation. | Nature structural & molecular biology | 204 | 19915590 |
| 1999 | Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC. | Molecular cell | 192 | 10635329 |
| 1999 | Group II chaperonins: new TRiC(k)s and turns of a protein folding machine. | Journal of molecular biology | 158 | 10550210 |
| 2016 | TRIC: an automated alignment strategy for reproducible protein quantification in targeted proteomics. | Nature methods | 144 | 27479329 |
| 2007 | TRIC channels are essential for Ca2+ handling in intracellular stores. | Nature | 144 | 17611541 |
| 2014 | Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. | Cell | 125 | 25467444 |
| 2014 | A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. | Cell reports | 123 | 25437552 |
| 2003 | The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex. | Molecular and cellular biology | 120 | 12697815 |
| 2001 | Review: cellular substrates of the eukaryotic chaperonin TRiC/CCT. | Journal of structural biology | 119 | 11580267 |
| 2019 | The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. | Cell | 111 | 30955883 |
| 2000 | Protein folding: versatility of the cytosolic chaperonin TRiC/CCT. | Current biology : CB | 106 | 10753735 |
| 2020 | The Molecular Chaperone CCT/TRiC: An Essential Component of Proteostasis and a Potential Modulator of Protein Aggregation. | Frontiers in genetics | 95 | 32265978 |
| 2019 | Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT. | Molecular cell | 94 | 31400849 |
| 2011 | The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. | The Journal of biological chemistry | 93 | 21880732 |
| 2015 | Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes. | Experimental cell research | 85 | 25704758 |
| 2014 | Modulation of STAT3 folding and function by TRiC/CCT chaperonin. | PLoS biology | 84 | 24756126 |
| 2003 | TRiC/CCT cooperates with different upstream chaperones in the folding of distinct protein classes. | The EMBO journal | 81 | 14517260 |
| 2016 | TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. | Proceedings of the National Academy of Sciences of the United States of America | 79 | 27601642 |
| 2003 | The group II chaperonin TRiC protects proteolytic intermediates from degradation in the MHC class I antigen processing pathway. | Molecular cell | 76 | 14527404 |
| 2018 | Pathway of Actin Folding Directed by the Eukaryotic Chaperonin TRiC. | Cell | 74 | 30100183 |
| 2015 | Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis. | International journal of molecular sciences | 72 | 26561808 |
| 2013 | TRiC's tricks inhibit huntingtin aggregation. | eLife | 72 | 23853712 |
| 2008 | Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT. | Nature structural & molecular biology | 72 | 18536725 |
| 2019 | The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story. | Current opinion in structural biology | 71 | 30978594 |
| 2011 | Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. | The EMBO journal | 71 | 22045336 |
| 2011 | TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance. | Cell metabolism | 67 | 21803293 |
| 2009 | Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation. | Development (Cambridge, England) | 63 | 19515693 |
| 1995 | The thermosome of Thermoplasma acidophilum and its relationship to the eukaryotic chaperonin TRiC. | European journal of biochemistry | 62 | 7867646 |
| 2010 | Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein. | Virology | 61 | 21093005 |
| 2013 | The cytosolic chaperonin CCT/TRiC and cancer cell proliferation. | PloS one | 60 | 23613750 |
| 2016 | Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta. | PLoS genetics | 56 | 27441836 |
| 2012 | Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT. | Proceedings of the National Academy of Sciences of the United States of America | 56 | 23197838 |
| 2006 | Role of the chaperonin CCT/TRiC complex in G protein betagamma-dimer assembly. | The Journal of biological chemistry | 56 | 16702223 |
| 2001 | Type D retrovirus Gag polyprotein interacts with the cytosolic chaperonin TRiC. | Journal of virology | 54 | 11222675 |
| 2022 | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT. | Cell | 53 | 36493755 |
| 2017 | The chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosol. | Cellular microbiology | 50 | 28067475 |
| 2018 | The TRiC chaperonin controls reovirus replication through outer-capsid folding. | Nature microbiology | 48 | 29531365 |
| 2004 | The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin. | FEBS letters | 47 | 15251459 |
| 2019 | An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity. | Proceedings of the National Academy of Sciences of the United States of America | 44 | 31492816 |
| 1976 | Factors affecting the sensitivity of replicating McCoy cells in the isolation and growth of chlamydia A (TRIC agents). | The Journal of hygiene | 43 | 6592 |
| 2016 | Pore architecture of TRIC channels and insights into their gating mechanism. | Nature | 42 | 27698420 |
| 2014 | Trophoblast retrieval and isolation from the cervix (TRIC) for noninvasive prenatal screening at 5 to 20 weeks of gestation. | Fertility and sterility | 42 | 24825422 |
| 2007 | Splice-site mutations in the TRIC gene underlie autosomal recessive nonsyndromic hearing impairment in Pakistani families. | Journal of human genetics | 42 | 18084694 |
| 2019 | TRiC/CCT Chaperonin: Structure and Function. | Sub-cellular biochemistry | 41 | 31939165 |
| 2010 | Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle. | The Journal of biological chemistry | 41 | 20858894 |
| 2020 | Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy. | Proceedings of the National Academy of Sciences of the United States of America | 39 | 32127489 |
| 2010 | Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel. | Biophysical journal | 39 | 20643059 |
| 2022 | Snapshots of actin and tubulin folding inside the TRiC chaperonin. | Nature structural & molecular biology | 38 | 35449234 |
| 2018 | TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A. | Nature communications | 37 | 29531219 |
| 2014 | The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation. | The Journal of biological chemistry | 36 | 25342745 |
| 2014 | Caenorhabditis elegans chaperonin CCT/TRiC is required for actin and tubulin biogenesis and microvillus formation in intestinal epithelial cells. | Molecular biology of the cell | 35 | 25143409 |
| 2022 | Ginkgolide B targets and inhibits creatine kinase B to regulate the CCT/TRiC-SK1 axis and exerts pro-angiogenic activity in middle cerebral artery occlusion mice. | Pharmacological research | 34 | 35513225 |
| 2011 | Functional Subunits of Eukaryotic Chaperonin CCT/TRiC in Protein Folding. | Journal of amino acids | 34 | 22312474 |
| 2019 | TRiC/CCT chaperonins are essential for organ growth by interacting with insulin/TOR signaling in Drosophila. | Oncogene | 33 | 30792539 |
| 2018 | In Vivo Function of the Chaperonin TRiC in α-Actin Folding during Sarcomere Assembly. | Cell reports | 32 | 29320728 |
| 2017 | Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy. | Scientific reports | 32 | 28623285 |
| 2012 | Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis. | Proceedings of the National Academy of Sciences of the United States of America | 32 | 23112166 |
| 2014 | The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans. | PloS one | 31 | 25080104 |
| 2021 | Structural and functional dissection of reovirus capsid folding and assembly by the prefoldin-TRiC/CCT chaperone network. | Proceedings of the National Academy of Sciences of the United States of America | 30 | 33836586 |
| 2012 | TRIC channels supporting efficient Ca(2+) release from intracellular stores. | Pflugers Archiv : European journal of physiology | 28 | 23242030 |
| 1994 | Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast. | The Journal of biological chemistry | 28 | 8034610 |
| 2020 | The TRiC/CCT Chaperonin and Its Role in Uncontrolled Proliferation. | Advances in experimental medicine and biology | 27 | 32297209 |
| 2015 | Vaccinia-Related Kinase 2 Controls the Stability of the Eukaryotic Chaperonin TRiC/CCT by Inhibiting the Deubiquitinating Enzyme USP25. | Molecular and cellular biology | 27 | 25755282 |
| 2015 | Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO. | The Journal of biological chemistry | 26 | 26706127 |
| 1994 | TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix. | Journal of cell science | 26 | 7876352 |
| 2017 | Genetic expansion of chaperonin-containing TCP-1 (CCT/TRiC) complex subunits yields testis-specific isoforms required for spermatogenesis in planarian flatworms. | Molecular reproduction and development | 24 | 29095551 |
| 2013 | Sarcoplasmic reticulum K(+) (TRIC) channel does not carry essential countercurrent during Ca(2+) release. | Biophysical journal | 24 | 24010658 |
| 2012 | Human TRiC complex purified from HeLa cells contains all eight CCT subunits and is active in vitro. | Cell stress & chaperones | 24 | 23011926 |
| 2008 | New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. | Pharmacology & therapeutics | 24 | 19095005 |
| 2016 | Crystal structures of the TRIC trimeric intracellular cation channel orthologues. | Cell research | 23 | 27909292 |
| 2013 | Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC. | Molecular and cellular biology | 22 | 24298020 |
| 1972 | Some consequences of the multiple infection of cell cultures by TRIC organisms. | The Journal of hygiene | 22 | 4501841 |
| 2019 | TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle. | Circulation research | 21 | 31805819 |
| 2018 | The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B. | Proceedings of the National Academy of Sciences of the United States of America | 21 | 30181275 |
| 2017 | TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan. | FEBS letters | 21 | 28963798 |
| 2011 | DFNB49 is an important cause of non-syndromic deafness in Czech Roma patients but not in the general Czech population. | Clinical genetics | 21 | 22097895 |
| 2004 | A new locus for nonsyndromic deafness DFNB49 maps to chromosome 5q12.3-q14.1. | Human genetics | 21 | 15538632 |
| 2023 | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. | Communications biology | 20 | 37193829 |
| 2016 | Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex. | Molecular biology of the cell | 20 | 27708139 |
| 2011 | Chaperonins induce an amyloid-like transformation of ovine prion protein: the fundamental difference in action between eukaryotic TRiC and bacterial GroEL. | Biochimica et biophysica acta | 20 | 21856455 |
| 2015 | Noninvasive detection of trophoblast protein signatures linked to early pregnancy loss using trophoblast retrieval and isolation from the cervix (TRIC). | Fertility and sterility | 19 | 26051097 |
| 2005 | Efficient production of native actin upon translation in a bacterial lysate supplemented with the eukaryotic chaperonin TRiC. | Biological chemistry | 19 | 16201870 |
| 2023 | Recognition of the CCT5 di-Glu degron by CRL4DCAF12 is dependent on TRiC assembly. | The EMBO journal | 18 | 36715408 |
| 2019 | tRic: a user-friendly data portal to explore the expression landscape of tRNAs in human cancers. | RNA biology | 18 | 31432762 |
| 2015 | Molecular genetics of MARVELD2 and clinical phenotype in Pakistani and Slovak families segregating DFNB49 hearing loss. | Human genetics | 18 | 25666562 |
| 1974 | Interactions of TRIC agents with macrophages: effects on lysosomal enzymes of the cell. | The Journal of hygiene | 18 | 4522724 |
| 2024 | Brain malformations and seizures by impaired chaperonin function of TRiC. | Science (New York, N.Y.) | 17 | 39480921 |
| 2020 | TRIC-A shapes oscillatory Ca2+ signals by interaction with STIM1/Orai1 complexes. | PLoS biology | 17 | 32330125 |
| 2018 | Development of a yeast internal-subunit eGFP labeling strategy and its application in subunit identification in eukaryotic group II chaperonin TRiC/CCT. | Scientific reports | 17 | 29403048 |
| 2007 | Conformational rearrangements of tail-less complex polypeptide 1 (TCP-1) ring complex (TRiC)-bound actin. | Biochemistry | 17 | 17417821 |
| 2023 | Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT. | Science advances | 16 | 36921056 |
| 2023 | A hierarchical assembly pathway directs the unique subunit arrangement of TRiC/CCT. | Molecular cell | 16 | 37625406 |
| 2023 | Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study. | Matrix biology : journal of the International Society for Matrix Biology | 15 | 37348683 |
| 2017 | Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A. | The Journal of physiology | 15 | 28387457 |
| 2015 | MARVELD2 (DFNB49) mutations in the hearing impaired Central European Roma population--prevalence, clinical impact and the common origin. | PloS one | 15 | 25885414 |
| 2008 | The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1. | The international journal of biochemistry & cell biology | 15 | 18775504 |