Affinage

MAP6

Microtubule-associated protein 6 · UniProt Q96JE9

Length
813 aa
Mass
86.5 kDa
Annotated
2026-06-10
100 papers in source corpus 12 papers cited in narrative 12 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MAP6 (STOP) is a calmodulin-regulated microtubule-associated protein that stabilizes microtubules against cold and depolymerizing drugs, a function central to neuronal microtubule architecture and transport (PMID:8700896, PMID:14567673). Stabilization is carried out by tandem Mn modules: a fragment spanning Mn1 and Mn2 (residues 90–177) recapitulates full activity, binding tubulin heterodimers 1:1 at a shared interface that is competitively occupied by Ca2+-calmodulin, providing the structural logic for calmodulin control (PMID:23831686). MAP6 localizes within the microtubule lumen, drives the lattice into a left-handed helical coil with apertures, and promotes microtubule growth in addition to conferring cold stability (PMID:32270043). Its compartmentalization is dynamically regulated: palmitoylation localizes MAP6 to the Golgi and secretory vesicles, and depalmitoylation by ABHD17A-C shuttles it onto axonal microtubules to support axon maturation (PMID:28521134), while CaMKII phosphorylation releases MAP6 from microtubules and redirects it to actin and synaptic compartments (PMID:16651267). Through these activities MAP6 is required for normal in vivo axonal transport (PMID:24704457), brakes retrograde lysosomal transport in dendrites via interaction with TMEM106B (PMID:24357581), and organizes the microtubule and sarcoplasmic reticulum networks needed for skeletal muscle calcium release and contractile force (PMID:30231928). Isoform diversity from a single gene produces cell-type-specific variants with distinct stabilizing properties in oligodendrocytes and astrocytes (PMID:15389836).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1996 High

    Established MAP6/STOP as a bona fide microtubule stabilizer, answering whether a single protein could account for cold-stable neuronal microtubules.

    Evidence cDNA cloning with in vitro binding and cellular reconstitution of cold stability, nocodazole resistance, and detyrosination

    PMID:8700896

    Open questions at the time
    • Did not resolve which protein domains mediate stabilization
    • Structural mechanism of lattice stabilization unknown
  2. 1998 Medium

    Defined the genomic organization of the single mammalian gene, framing how isoform diversity could arise.

    Evidence Genomic cloning, chromosomal mapping, and transcription start site mapping in mouse

    PMID:9501006

    Open questions at the time
    • Did not characterize the spliced isoforms functionally
    • Promoter usage in different cell types not resolved
  3. 2003 High

    Connected MAP6 domain architecture to calmodulin regulation and to in vivo function, linking molecular activity to organismal phenotype.

    Evidence Domain analysis combined with STOP-knockout mouse phenotyping of synaptic and behavioral defects

    PMID:14567673

    Open questions at the time
    • Molecular basis of calmodulin competition not yet structurally defined
    • Causal chain from microtubule defect to behavior unclear
  4. 2004 Medium

    Showed that distinct cell types express different MAP6 isoforms with different stabilizing capacities, explaining functional diversity from one gene.

    Evidence Western blot and cold/nocodazole assays in cultured oligodendrocytes and astrocytes

    PMID:15389836

    Open questions at the time
    • Structural basis for differential nocodazole resistance not defined
    • Physiological role of glial isoforms not tested in vivo
  5. 2006 High

    Identified phosphorylation as a switch redirecting MAP6 from microtubules to actin/synaptic compartments, revealing regulated relocalization.

    Evidence In vitro and in vivo CaMKII phosphorylation, co-localization imaging, and actin-binding assay in neurons

    PMID:16651267

    Open questions at the time
    • Functional consequence of synaptic relocalization not directly measured
    • Phosphatase reversing the switch not identified
  6. 2012 Medium

    Established an evolutionarily conserved family by showing Mn-module-homologous proteins stabilize axonemal microtubules in flagellated organisms.

    Evidence Heterologous expression and RNAi motility phenotyping of TbSAXO in T. brucei

    PMID:22355359

    Open questions at the time
    • Direct relevance to mammalian MAP6 ciliary function not addressed
    • Ortholog comparison limited to domain homology
  7. 2013 High

    Provided the structural basis of stabilization and calmodulin control, showing the Mn modules bind tubulin 1:1 at a site competed by Ca2+-calmodulin.

    Evidence In vitro stabilization assays, NMR spectroscopy, and Ca2+-calmodulin competition with the Mn1-Mn2 fragment

    PMID:23831686

    Open questions at the time
    • Atomic-resolution complex structure not obtained
    • Stoichiometry on full lattice in cells not confirmed
  8. 2013 High

    Defined a physical and functional MAP6 partner controlling dendritic organelle transport, expanding its role beyond microtubule stabilization.

    Evidence Co-IP plus reciprocal shRNA/overexpression rescue with live lysosomal imaging in primary neurons

    PMID:24357581

    Open questions at the time
    • Mechanism by which the TMEM106B/MAP6 interaction brakes transport unresolved
    • Direct binding interface not mapped
  9. 2014 Medium

    Demonstrated that MAP6 is required for normal axonal transport in vivo and that microtubule-targeting drugs can rescue the defect.

    Evidence Manganese-enhanced MRI of axonal transport in MAP6 KO mice with Epothilone D rescue

    PMID:24704457

    Open questions at the time
    • Cargo-specific transport effects not resolved
    • Link to the molecular stabilization mechanism inferred not shown directly
  10. 2017 High

    Revealed palmitoylation-controlled trafficking that shuttles MAP6 between membranes and axonal microtubules during maturation.

    Evidence Live imaging, palmitoylation assays, and ABHD17A-C writer/eraser manipulation in cultured neurons

    PMID:28521134

    Open questions at the time
    • Palmitoyltransferase adding the modification not identified
    • Coordination with phosphorylation switch not addressed
  11. 2018 Medium

    Extended MAP6 function to skeletal muscle, showing it organizes microtubule and SR networks needed for calcium release and force.

    Evidence KO mouse force measurement, EM, and Fluo-4 calcium imaging in myotubes

    PMID:30231928

    Open questions at the time
    • Muscle-relevant MAP6 isoform not defined
    • Mechanism linking microtubule organization to SR calcium release unresolved
  12. 2020 High

    Established the structural mode of action, showing MAP6 acts from inside the microtubule lumen to coil the lattice and promote growth.

    Evidence Cryo-EM/tomography and in vitro reconstitution of microtubule dynamics with MAP6

    PMID:32270043

    Open questions at the time
    • How intraluminal access is achieved in vivo unclear
    • Relationship of lattice coiling to cold stability mechanistically open

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the palmitoylation, phosphorylation, and calmodulin-competition inputs are integrated to spatially and temporally direct MAP6 between microtubules, actin, membranes, and partner complexes remains unresolved.
  • No unified model coupling the three regulatory switches
  • In vivo dynamics of MAP6 redistribution not measured
  • Cross-talk with TMEM106B-dependent transport not integrated with stabilization role

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0008092 cytoskeletal protein binding 3
Localization
GO:0005856 cytoskeleton 3 GO:0005794 Golgi apparatus 1 GO:0031410 cytoplasmic vesicle 1
Partners
ABHD17ACALM1CAMK2TMEM106B

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 STOP (MAP6) is a 100.5-kDa microtubule-associated protein with two distinct repeat domains; it binds microtubules and Ca2+-calmodulin in vitro, and when expressed in cells reconstitutes microtubule cold stability, nocodazole resistance, and tubulin detyrosination, demonstrating its role as a microtubule stabilizer. cDNA cloning, in vitro binding assays, transfection of STOP cDNA into cells lacking cold-stable microtubules with phenotypic readouts Proceedings of the National Academy of Sciences of the United States of America High 8700896
1998 The mouse STOP gene (Mtap6) is a single-copy gene on chromosome 7 composed of 4 exons spanning 67 kb, with transcription initiating at multiple sites in a TATA-less promoter region, encoding a 906-amino-acid protein with 91% identity to rat brain STOP. Genomic cloning, Southern blotting, chromosomal mapping, transcription start site mapping Biochemical and biophysical research communications Medium 9501006
2003 STOP proteins are calmodulin-binding, calmodulin-regulated microtubule-associated proteins encoded by a single mammalian gene; they exhibit cell-specific variability through mRNA splicing and alternative promoter use, and their microtubule-stabilizing activity is mediated by two classes of bifunctional calmodulin- and microtubule-binding motifs with distinct binding properties in vivo. STOP suppression in mice induces synaptic defects and neuroleptic-sensitive behavioral disorders. Biochemical characterization, domain analysis, STOP-knockout mouse phenotyping Biochemistry High 14567673
2004 Oligodendrocytes express a major STOP isoform of 89 kDa (O-STOP) that induces microtubule resistance to both cold and nocodazole, while astrocytes express STOP isoforms of 42, 48, and 60 kDa (A-STOP) that confer only cold stability (not nocodazole resistance), demonstrating cell-type-specific isoform expression and differential microtubule-stabilizing activity. Western blot, immunofluorescence, cold/nocodazole treatment assays in cultured oligodendrocytes and astrocytes Journal of neuroscience research Medium 15389836
2006 STOP/MAP6 is phosphorylated by CaMKII in vitro and in vivo on at least two independent sites; phosphorylated STOP does not bind or co-localize with microtubules but instead co-localizes with actin assemblies and synaptic protein clusters in differentiated neurons. STOP also binds actin in vitro, suggesting phosphorylation-driven translocation from microtubules to synaptic compartments. In vitro kinase assay, in vivo phosphorylation (metabolic labeling), immunofluorescence co-localization, in vitro actin-binding assay The Journal of biological chemistry High 16651267
2012 A MAP6-related protein in Trypanosoma brucei (TbSAXO) stabilizes microtubules via domains homologous to the Mn modules of MAP6; TbSAXO is an axonemal protein required for flagellum motility, defining a family of MAP6-related SAXO proteins present in ciliated/flagellated organisms. Heterologous expression, microtubule stabilization assay, RNAi knockdown in T. brucei with motility phenotyping, domain mapping PloS one Medium 22355359
2013 MAP6 identified as a novel interacting protein for TMEM106B by co-immunoprecipitation; MAP6 overexpression inhibits dendritic branching and increases retrograde lysosomal transport in dendrites, while MAP6 knockdown rescues the dendritic and lysosomal transport defects caused by TMEM106B knockdown, establishing a functional TMEM106B/MAP6 interaction that acts as a molecular brake on retrograde lysosomal transport. Co-immunoprecipitation, shRNA knockdown, overexpression, live-cell imaging of lysosomal transport, dendritic morphology quantification in primary neurons The EMBO journal High 24357581
2013 A short MAP6 fragment encompassing its Mn1 and Mn2 modules (residues 90–177) recapitulates full-length MAP6-N microtubule-stabilizing activity with a 1:1 stoichiometry per tubulin heterodimer; NMR shows both Mn modules bind microtubules at a common interface; Ca2+-calmodulin competes with microtubules for MAP6 binding at the same amino-acid stretch, providing the structural basis for calmodulin regulation. Biochemical microtubule stabilization assays, NMR spectroscopy, Ca2+-calmodulin competition assays The Journal of biological chemistry High 23831686
2014 MAP6 KO mice display reduced neuronal Mn2+ axonal transport rate in vivo, with stronger defects in long-range and polysynaptic connections; chronic Epothilone D treatment restores axonal transport and alleviates behavioral defects, demonstrating that MAP6 is required for normal in vivo axonal transport. MEMRI (manganese-enhanced MRI) in vivo axonal transport measurement, pharmacological rescue with Epothilone D NeuroImage Medium 24704457
2017 MAP6 undergoes dynamic palmitoylation that controls its subcellular localization: in unpolarized neurons MAP6 resides at the Golgi and in secretory vesicles; as neurons mature, palmitoylated MAP6 is translocated to the proximal axon where it binds and stabilizes microtubules. Depalmitoylation by ABHD17A-C enzymes shuttles MAP6 between membranes and microtubules and is required for MAP6 retention in axons and axon maturation. Live-cell imaging, palmitoylation assays, ABHD17 overexpression/knockdown, immunofluorescence fractionation in cultured neurons and in situ Neuron High 28521134
2020 MAP6 localizes inside the lumen of microtubules (intraluminal localization) rather than exclusively on the outer surface; MAP6 induces neuronal microtubules to coil into a left-handed helix and forms apertures (holes) in the microtubule lattice, likely to relieve mechanical stress. MAP6 also promotes microtubule growth in addition to conferring cold stability. Cryo-electron microscopy/tomography, in vitro microtubule reconstitution with MAP6, quantitative imaging of microtubule dynamics Science advances High 32270043
2018 MAP6 deletion in mice results in skeletal muscle dysfunction: reduced muscle force, altered microtubule network and sarcoplasmic reticulum organization, and reduced calcium release during contraction in cultured myotubes, demonstrating a role for MAP6 in organizing intracellular structures required for efficient muscle contraction. RT-PCR, western blot, in vivo electrostimulation force measurement, immunofluorescence, electron microscopy, Fluo-4 calcium imaging in KO vs. WT mice Skeletal muscle Medium 30231928

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell 3389 22608085
1995 When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. RNA (New York, N.Y.) 496 7489507
2008 Controlling morpholino experiments: don't stop making antisense. Development (Cambridge, England) 472 18403413
2000 Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Progress in nucleic acid research and molecular biology 299 10697411
2017 CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations. Nature methods 277 28581493
2014 Therapeutics based on stop codon readthrough. Annual review of genomics and human genetics 237 24773318
2015 Transcription termination and the control of the transcriptome: why, where and how to stop. Nature reviews. Molecular cell biology 236 25650800
2015 Structural basis for stop codon recognition in eukaryotes. Nature 235 26245381
2014 Evidence of efficient stop codon readthrough in four mammalian genes. Nucleic acids research 178 25013167
2005 Viral stop-and-go along microtubules: taking a ride with dynein and kinesins. Trends in microbiology 168 15950476
2001 Actin-based motility: stop and go with Ena/VASP proteins. Trends in biochemical sciences 168 11295557
2001 Cell therapy in Parkinson's disease - stop or go? Nature reviews. Neuroscience 168 11331920
2011 Termination and antitermination: RNA polymerase runs a stop sign. Nature reviews. Microbiology 154 21478900
2009 TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunological reviews 150 19290931
1992 X chromosome-linked Kallmann syndrome: stop mutations validate the candidate gene. Proceedings of the National Academy of Sciences of the United States of America 150 1518845
2013 The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes. The EMBO journal 147 24357581
2016 Stop pulling my strings - what telomeres taught us about the DNA damage response. Nature reviews. Molecular cell biology 139 27165790
2007 Green light: a signal to slow down or stop. Journal of experimental botany 137 17630292
2016 Should I stop or should I go? The role of complexin in neurotransmitter release. Nature reviews. Neuroscience 122 26806630
2004 Stop and go traffic to tune T cell responses. Immunity 120 15357942
2023 Transformer for one stop interpretable cell type annotation. Nature communications 117 36641532
2018 The stop-and-go traffic regulating protein biogenesis: How translation kinetics controls proteostasis. The Journal of biological chemistry 116 30504455
2005 Cough and glottic-stop reflex sensitivity in health and disease. Chest 116 15705995
2018 VDAC Regulation: A Mitochondrial Target to Stop Cell Proliferation. Advances in cancer research 113 29551129
2020 FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease. Nature 110 32581359
2008 The reverse stop-signal model for CTLA4 function. Nature reviews. Immunology 110 18219311
2018 Why Do Sex Chromosomes Stop Recombining? Trends in genetics : TIG 104 29716744
1994 When replication forks stop. Molecular microbiology 98 7984091
2017 Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Neuron 94 28521134
1996 Cloning, expression, and properties of the microtubule-stabilizing protein STOP. Proceedings of the National Academy of Sciences of the United States of America 92 8700896
2004 Pharmacologic therapy for stop mutations: how much CFTR activity is enough? Current opinion in pulmonary medicine 87 15510065
2002 Non-stop decay--a new mRNA surveillance pathway. BioEssays : news and reviews in molecular, cellular and developmental biology 84 12210514
2000 Lessons from the Stroke Prevention Trial in Sickle Cell Anemia (STOP) study. Journal of child neurology 84 10830201
2023 Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII. Molecular cell 83 36634677
1996 Three, four or more: the translational stop signal at length. Molecular microbiology 81 8858577
2006 Regulated translational bypass of stop codons in yeast. Trends in microbiology 77 17187982
2022 Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus. Nature reviews. Neurology 74 35538233
2017 Should We Stop Saying 'Glia' and 'Neuroinflammation'? Trends in molecular medicine 71 28499701
2021 Stop helping pathogens: engineering plant susceptibility genes for durable resistance. Current opinion in biotechnology 65 34153774
1998 How protein reads the stop codon and terminates translation. Genes to cells : devoted to molecular & cellular mechanisms 65 9685178
2020 MAP6 is an intraluminal protein that induces neuronal microtubules to coil. Science advances 64 32270043
2003 STOP proteins. Biochemistry 64 14567673
2019 Start-Stop Assembly: a functionally scarless DNA assembly system optimized for metabolic engineering. Nucleic acids research 63 30462270
2016 Translational termination without a stop codon. Science (New York, N.Y.) 62 27934701
2012 Cancer syndromes and therapy by stop-codon readthrough. Trends in molecular medicine 60 23044248
2001 Stop making nonSense: the C. elegans smg genes. Trends in genetics : TIG 60 11672865
2020 Deciphering the molecular mechanism of stop codon readthrough. Biological reviews of the Cambridge Philosophical Society 56 33089614
2015 Why does the gout attack stop? A roadmap for the immune pathogenesis of gout. RMD open 56 26557370
2014 "Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinases. World journal of biological chemistry 55 24921005
2015 Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis. Proceedings of the National Academy of Sciences of the United States of America 54 25901317
2008 Crossroads of cytokine signaling--the chase to stop muscle cachexia. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 54 19261984
2016 Next stop for the CRISPR revolution: RNA-guided epigenetic regulators. The FEBS journal 51 27248712
2004 Next stop, the twilight zone: hedgehog network regulation of mammary gland development. Journal of mammary gland biology and neoplasia 48 15300011
2012 A MAP6-related protein is present in protozoa and is involved in flagellum motility. PloS one 47 22355359
2023 Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment. Nature 46 36631608
2018 When to Stop Eculizumab in Complement-Mediated Thrombotic Microangiopathies. American journal of nephrology 44 30110670
2020 STOP floxing around: Specificity and leakiness of inducible Cre/loxP systems. European journal of immunology 43 32125704
2020 ELX-02 Generates Protein via Premature Stop Codon Read-Through without Inducing Native Stop Codon Read-Through Proteins. The Journal of pharmacology and experimental therapeutics 43 32376628
2020 Stop testing for autoantibodies to the VGKC-complex: only request LGI1 and CASPR2. Practical neurology 43 32595134
2016 Evolutionary Dynamics of Abundant Stop Codon Readthrough. Molecular biology and evolution 43 27604222
2010 Principles of stop-codon reading on the ribosome. Nature 43 20512119
2006 Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia. Schizophrenia research 41 16624526
2012 Reduced expression of STOP/MAP6 in mice leads to cognitive deficits. Schizophrenia bulletin 40 23002183
2010 Go or stop? Divergent roles of Reelin in radial neuronal migration. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 39 20817919
2003 Stop codon suppression via inhibition of eRF1 expression. RNA (New York, N.Y.) 39 12756323
2006 Phosphorylation of microtubule-associated protein STOP by calmodulin kinase II. The Journal of biological chemistry 38 16651267
2021 Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae. PLoS genetics 37 33878104
2018 Pseudouridines have context-dependent mutation and stop rates in high-throughput sequencing. RNA biology 37 29683381
2008 Activated protein C--an anticoagulant that does more than stop clots. The international journal of biochemistry & cell biology 34 18249579
2005 Polypeptide chain termination and stop codon readthrough on eukaryotic ribosomes. Reviews of physiology, biochemistry and pharmacology 34 15928926
2021 CRISPR-BETS: a base-editing design tool for generating stop codons. Plant biotechnology journal 33 34669232
2016 RNA folding pathways in stop motion. Nucleic acids research 33 27091499
2006 Altered expression of synaptic protein mRNAs in STOP (MAP6) mutant mice. Journal of psychopharmacology (Oxford, England) 33 17050659
2012 The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances. Journal of neurochemistry 32 22146001
2020 Metabolic stress promotes stop-codon readthrough and phenotypic heterogeneity. Proceedings of the National Academy of Sciences of the United States of America 31 32839318
2004 Astrocytes and oligodendrocytes express different STOP protein isoforms. Journal of neuroscience research 31 15389836
2019 Homozygous stop mutation in AHR causes autosomal recessive foveal hypoplasia and infantile nystagmus. Brain : a journal of neurology 30 31009037
2017 Pyrrolysine Amber Stop-Codon Suppression: Development and Applications. Chembiochem : a European journal of chemical biology 30 28758366
2014 Neuronal transport defects of the MAP6 KO mouse - a model of schizophrenia - and alleviation by Epothilone D treatment, as observed using MEMRI. NeuroImage 30 24704457
2020 Translational read-through promotes aggregation and shapes stop codon identity. Nucleic acids research 29 32128584
2012 Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice. Journal of neurochemistry 28 23013328
1999 UGA: a dual signal for 'stop' and for recoding in protein synthesis. Biochemistry. Biokhimiia 28 10648957
2023 Molecular basis of translation termination at noncanonical stop codons in human mitochondria. Science (New York, N.Y.) 27 37141370
2021 Read-through approach for stop mutations in Duchenne muscular dystrophy. An update. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 27 33870095
2011 Proliferation/Quiescence: When to start? Where to stop? What to stock? Cell division 27 22152110
2021 De novo stop-loss variants in CLDN11 cause hypomyelinating leukodystrophy. Brain : a journal of neurology 26 33313762
2019 When to stop: an update on molecular mechanisms of floral meristem termination. Journal of experimental botany 26 30916342
2018 Purifying and positive selection in the evolution of stop codons. Scientific reports 26 29915293
2018 Stop eating plastic, molecular signaling of bisphenol A in breast cancer. Environmental science and pollution research international 26 29959737
2016 Coevolution between Stop Codon Usage and Release Factors in Bacterial Species. Molecular biology and evolution 26 27297468
1998 Genomic structure and chromosomal mapping of the mouse STOP gene (Mtap6). Biochemical and biophysical research communications 26 9501006
2019 Can we stop nucleoside analogues before HBsAg loss? Journal of viral hepatitis 25 30803099
2013 Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin. The Journal of biological chemistry 25 23831686
2000 Phaco-chop versus stop-and-chop nucleotomy for phacoemulsification. Journal of cataract and refractive surgery 25 11084272
2016 Stop chronic kidney disease progression: Time is approaching. World journal of nephrology 24 27152262
2016 In vitro suppression of two different stop codons. Biotechnology and bioengineering 24 27882539
2020 How to learn to stop worrying and love environmental DNA monitoring. Aquatic ecosystem health & management 23 33364913
2018 Neural crest emigration: From start to stop. Genesis (New York, N.Y. : 2000) 22 29369490
2017 3D imaging of the brain morphology and connectivity defects in a model of psychiatric disorders: MAP6-KO mice. Scientific reports 22 28871106
2018 Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction. Skeletal muscle 21 30231928

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