Affinage

MAP6

Microtubule-associated protein 6 · UniProt Q96JE9

Length
813 aa
Mass
86.5 kDa
Annotated
2026-04-28
100 papers in source corpus 12 papers cited in narrative 12 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MAP6 (also known as STOP) is a calmodulin-regulated microtubule-associated protein that stabilizes microtubules in neurons, muscle, and other cell types, and coordinates intracellular transport and organelle positioning. Its Mn modules bind tubulin heterodimers at 1:1 stoichiometry, and Ca²⁺-calmodulin competes for the same binding surface to dynamically regulate microtubule stabilization (PMID:23831686); structurally, MAP6 localizes to the microtubule lumen, where it induces left-handed helical coiling and lattice apertures and promotes microtubule growth (PMID:32270043). Dynamic palmitoylation, regulated by ABHD17 depalmitoylases, shuttles MAP6 between membranes and microtubules and is required for its axon-specific retention during neuronal polarization (PMID:28521134). MAP6 also interacts with TMEM106B to restrain retrograde lysosomal transport in dendrites (PMID:24357581), and its loss in mice produces defective axonal transport, impaired brain connectivity, reduced synaptic protein expression, skeletal muscle weakness with altered calcium handling, and dose-dependent cognitive and social deficits (PMID:24704457, PMID:28871106, PMID:30231928, PMID:23002183).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1998 Medium

    Establishing the gene structure of MAP6/STOP — including exon organization, calmodulin-binding capacity, and chromosomal locus — provided the foundation for subsequent mechanistic work on this microtubule-associated protein.

    Evidence Genomic cloning, sequencing, and transcription start site mapping of mouse Mtap6

    PMID:9501006

    Open questions at the time
    • Promoter regulatory elements not functionally tested
    • Human gene structure not characterized in this study
  2. 2004 Medium

    Demonstration that distinct MAP6/STOP isoforms in different cell types confer different levels of microtubule stability (cold versus nocodazole resistance) established that MAP6 function is isoform- and cell-type-dependent.

    Evidence Western blot, immunofluorescence, and in vitro microtubule stabilization assays across neurons, oligodendrocytes, astrocytes, and fibroblasts

    PMID:15389836

    Open questions at the time
    • Structural basis for differential stabilizing capacity of isoforms unknown
    • In vivo relevance of individual isoforms not tested
  3. 2012 Medium

    The finding that MAP6 Mn-domain homologs in Trypanosoma brucei (SAXO proteins) stabilize axonemal microtubules and are required for flagellum motility revealed that MAP6-family microtubule stabilization is an ancient, evolutionarily conserved function.

    Evidence Heterologous expression, in vitro MT stabilization, RNAi knockdown in T. brucei

    PMID:22355359

    Open questions at the time
    • Structural conservation of Mn-module–tubulin interface not resolved
    • Direct functional complementation between mammalian MAP6 and SAXO not tested
  4. 2012 Medium

    Behavioral analysis of MAP6 heterozygous and KO mice revealed that MAP6 dosage has high penetrance on cognitive and social abilities, with perinatal stress exacerbating positive-symptom-like phenotypes — linking microtubule stabilization to complex behavior.

    Evidence Behavioral testing battery (locomotor, social interaction, amphetamine sensitivity) in heterozygous and KO mice with/without maternal deprivation

    PMID:23002183

    Open questions at the time
    • Cellular mechanism linking MAP6 loss to behavioral deficits not dissected
    • Relevance to human psychiatric disease not established by direct genetic evidence
  5. 2013 High

    NMR-resolved domain dissection showed that MAP6 Mn modules each constitute complete microtubule-binding domains that bind at 1:1 stoichiometry per tubulin heterodimer, and that Ca²⁺-calmodulin competes for overlapping residues — providing the first molecular mechanism for calmodulin-dependent regulation of MAP6-mediated microtubule stability.

    Evidence NMR spectroscopy, biochemical binding and calmodulin competition assays, cold/nocodazole stabilization assays in vitro

    PMID:23831686

    Open questions at the time
    • Atomic-resolution structure of Mn–tubulin complex not obtained
    • How calmodulin regulation is triggered in vivo (calcium dynamics) not addressed
  6. 2013 High

    Discovery that MAP6 physically interacts with TMEM106B and functions as a brake on retrograde lysosomal transport in dendrites revealed a non-structural role for MAP6 in organelle trafficking, with epistasis experiments showing MAP6 acts downstream of TMEM106B.

    Evidence Co-immunoprecipitation, live lysosomal imaging, shRNA knockdown/overexpression, and Rab7-RILP epistasis in primary neurons

    PMID:24357581

    Open questions at the time
    • Direct binding domain on MAP6 for TMEM106B not mapped
    • Whether MAP6-TMEM106B interaction is palmitoylation-dependent unknown
  7. 2014 Medium

    Manganese-enhanced MRI in MAP6 KO mice demonstrated that MAP6 is required for normal axonal transport in vivo, particularly in long-range and polysynaptic pathways, and that the microtubule-stabilizing drug Epothilone D rescues these deficits — providing causal evidence that MAP6's transport role depends on microtubule integrity.

    Evidence MEMRI imaging and pharmacological rescue with Epothilone D in MAP6 KO vs. wild-type mice

    PMID:24704457

    Open questions at the time
    • Molecular cargo affected by MAP6 loss not identified
    • Whether transport rescue also corrects behavioral deficits long-term unknown
  8. 2017 High

    Dynamic palmitoylation was identified as the switch controlling MAP6 partitioning between membranes and microtubules; ABHD17 depalmitoylases release MAP6 from membranes to enable its axon-specific microtubule binding during neuronal polarization.

    Evidence Palmitoylation assays, FRAP, live-cell imaging, ABHD17 overexpression/knockdown in cultured neurons

    PMID:28521134

    Open questions at the time
    • Which palmitoyl transferase(s) initially palmitoylate MAP6 not identified
    • Whether palmitoylation also regulates MAP6 in non-neuronal cells unknown
  9. 2017 Medium

    High-resolution MRI and DTI of MAP6-KO brains established that MAP6 is essential for normal brain connectivity, with reduced cerebellar/thalamic volumes and disrupted major white matter tracts.

    Evidence 3D MRI, diffusion tensor imaging, fiber tractography, and optical imaging of cleared MAP6-KO mouse brains

    PMID:28871106

    Open questions at the time
    • Whether connectivity defects are developmental or degenerative not resolved
    • Cell-type-specific contributions not dissected
  10. 2018 Medium

    MAP6 deletion was shown to cause skeletal muscle weakness with disorganized sarcoplasmic reticulum and reduced calcium release, extending MAP6's physiological role beyond the nervous system to excitation-contraction coupling.

    Evidence MAP6 KO mouse, in vivo force measurements, electron microscopy, Fluo-4 calcium imaging in myotubes

    PMID:30231928

    Open questions at the time
    • Whether muscle phenotype is due to microtubule instability or a non-MT function of MAP6 not distinguished
    • MAP6 isoform responsible for muscle function not identified
  11. 2020 High

    Cryo-EM/ET revealed that MAP6 occupies the microtubule lumen — an unprecedented localization — where it induces left-handed helical coiling and lattice apertures, and promotes microtubule growth rather than merely preventing depolymerization, fundamentally revising the model of how MAP6 stabilizes microtubules.

    Evidence Cryo-electron microscopy/tomography with in vitro reconstituted MAP6–tubulin assemblies, fluorescence microscopy

    PMID:32270043

    Open questions at the time
    • Intraluminal binding site on tubulin not resolved at atomic resolution
    • How MAP6 enters the lumen is unknown
    • Whether intraluminal localization occurs in vivo confirmed only indirectly

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include: how MAP6 enters the microtubule lumen, the atomic structure of the Mn–tubulin interface, whether palmitoylation governs the MAP6–TMEM106B interaction, and the molecular identity of cargoes whose transport depends on MAP6.
  • Mechanism of luminal entry unknown
  • No high-resolution co-structure of Mn domain bound to tubulin
  • Relationship between palmitoylation state and TMEM106B interaction untested
  • Specific transport cargoes disrupted in MAP6 KO not identified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 4 GO:0098772 molecular function regulator activity 2
Localization
GO:0005856 cytoskeleton 3 GO:0005829 cytosol 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-112316 Neuronal System 3 R-HSA-1852241 Organelle biogenesis and maintenance 2 R-HSA-5653656 Vesicle-mediated transport 2
Partners
ABHD17AABHD17BABHD17CCALM1TMEM106B

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 MAP6 interacts with TMEM106B and controls dendritic trafficking of lysosomes; MAP6 overexpression inhibits dendritic branching and increases retrograde lysosomal transport in dendrites, while MAP6 knockdown rescues dendritic phenotypes caused by TMEM106B knockdown, indicating MAP6 acts as a molecular brake for retrograde lysosomal transport. Co-immunoprecipitation (MAP6–TMEM106B interaction), live imaging of lysosomal transport, shRNA knockdown and overexpression in primary neurons, dominant-negative Rab7-RILP rescue experiments The EMBO journal High 24357581
2017 MAP6 is dynamically palmitoylated; palmitoylation mediates shuttling of MAP6 between membranes and microtubules and is required for MAP6 retention in the proximal axon, where it stabilizes microtubules during neuronal polarization. ABHD17A-C depalmitoylating enzymes regulate this process. Live-cell imaging, FRAP, palmitoylation assays, overexpression/knockdown of ABHD17 enzymes in cultured neurons and in situ, axon/dendrite fractionation Neuron High 28521134
2020 MAP6 localizes to the lumen of microtubules (intraluminal), induces neuronal microtubules to coil into a left-handed helix, and forms apertures in the microtubule lattice; MAP6 also promotes microtubule growth rather than merely preventing depolymerization. Cryo-electron microscopy/tomography, in vitro reconstitution with purified MAP6 and tubulin, fluorescence microscopy Science advances High 32270043
2013 MAP6 stabilizes microtubules via its Mn1 and Mn2 modules (MAP6(90-177)), which bind microtubules with 1:1 MAP6:tubulin heterodimer stoichiometry; each Mn module constitutes a full microtubule-binding domain. Ca²⁺-calmodulin competes with microtubules for MAP6 binding through overlapping residues, providing a mechanism for calmodulin-dependent regulation of microtubule stability. NMR spectroscopy, biochemical binding assays (in vitro), microtubule stabilization assays in cold/nocodazole conditions, calmodulin competition assays The Journal of biological chemistry High 23831686
2012 A MAP6-related protein (TbSAXO) in Trypanosoma brucei is an axonemal microtubule-stabilizing protein; its Mn-domain homologs mediate microtubule binding and stabilization, and TbSAXO is required for flagellum motility, identifying a conserved family of MAP6-related SAXO proteins in ciliated/flagellated organisms. Heterologous expression, in vitro microtubule stabilization assays, RNAi knockdown in T. brucei, immunolocalization PloS one Medium 22355359
2004 Different cell types (neurons, oligodendrocytes, astrocytes, fibroblasts) express distinct isoforms of STOP/MAP6 (N-STOP, E-STOP, O-STOP, A-STOP, F-STOP) with differing microtubule-stabilizing capacities: neuronal and oligodendrocyte isoforms confer resistance to both cold and nocodazole, whereas astrocyte and fibroblast isoforms confer resistance only to cold. Western blot, immunofluorescence, in vitro microtubule stabilization assays (cold and nocodazole treatment) in cultured cell types Journal of neuroscience research Medium 15389836
1998 The mouse STOP gene (Mtap6) maps to chromosome 7 E2-F1, is composed of 4 exons, encodes a 906-amino acid calmodulin-regulated microtubule-associated protein with 91% identity to rat brain STOP, and initiates transcription from multiple sites in a TATA-less promoter region. Genomic cloning, sequencing, chromosomal mapping, transcription start site mapping Biochemical and biophysical research communications Medium 9501006
2014 MAP6 KO mice exhibit reduced neuronal Mn²⁺ transport in vivo, particularly in long-range and polysynaptic connections, indicating axonal transport defects; treatment with the microtubule-stabilizing drug Epothilone D rescues axonal transport in MAP6 KO mice and alleviates behavioral deficits. Manganese-enhanced MRI (MEMRI) in MAP6 KO vs. wild-type mice, pharmacological rescue with Epothilone D NeuroImage Medium 24704457
2018 Deletion of MAP6 in mice causes skeletal muscle dysfunction including muscle weakness, alterations in microtubule network and sarcoplasmic reticulum organization, and reduced calcium release during contraction, establishing a role for MAP6 in skeletal muscle excitation-contraction coupling. MAP6 KO mouse line, in vivo force measurement, immunofluorescence, electron microscopy, Fluo-4 calcium imaging in myotubes Skeletal muscle Medium 30231928
2012 Reduced expression of STOP/MAP6 in heterozygous mice causes prominent deficits in social interaction and learning, and perinatal stress exacerbates behavioral phenotypes related to positive symptoms, demonstrating that MAP6 dosage has high penetrance on cognitive abilities. Behavioral testing battery in STOP heterozygous and KO mice with/without maternal deprivation; locomotor, amphetamine, and social interaction assays Schizophrenia bulletin Medium 23002183
2017 MAP6-KO mice show structural brain abnormalities including reduced cerebellar and thalamic volumes and altered integrity/orientation of white matter tracts (anterior commissure, corpus callosum, corticospinal tract, fornix), establishing MAP6 as necessary for normal brain connectivity. High-resolution 3D MRI, diffusion tensor imaging (DTI), fiber tractography, optical imaging of cleared brains in MAP6-KO mice Scientific reports Medium 28871106
2006 STOP/MAP6 null and heterozygous mice show decreased mRNA expression of presynaptic proteins (synaptophysin, GAP-43, VGlut1) and postsynaptic spinophilin in hippocampus, cerebellum, and cortex, linking MAP6-dependent microtubule stability to synaptic protein expression. In situ hybridization histochemistry in STOP null, heterozygous, and wild-type mice Journal of psychopharmacology (Oxford, England) Low 17050659

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell 3345 22608085
1995 When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. RNA (New York, N.Y.) 494 7489507
2008 Controlling morpholino experiments: don't stop making antisense. Development (Cambridge, England) 472 18403413
1999 A stop-codon mutation in the BRI gene associated with familial British dementia. Nature 386 10391242
2017 CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations. Nature methods 272 28581493
2014 Therapeutics based on stop codon readthrough. Annual review of genomics and human genetics 236 24773318
2015 Transcription termination and the control of the transcriptome: why, where and how to stop. Nature reviews. Molecular cell biology 234 25650800
2015 Structural basis for stop codon recognition in eukaryotes. Nature 232 26245381
2014 Evidence of efficient stop codon readthrough in four mammalian genes. Nucleic acids research 175 25013167
2001 Actin-based motility: stop and go with Ena/VASP proteins. Trends in biochemical sciences 168 11295557
2005 Viral stop-and-go along microtubules: taking a ride with dynein and kinesins. Trends in microbiology 167 15950476
2001 Cell therapy in Parkinson's disease - stop or go? Nature reviews. Neuroscience 166 11331920
2011 Termination and antitermination: RNA polymerase runs a stop sign. Nature reviews. Microbiology 152 21478900
2009 TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunological reviews 150 19290931
1992 X chromosome-linked Kallmann syndrome: stop mutations validate the candidate gene. Proceedings of the National Academy of Sciences of the United States of America 150 1518845
2012 Sense from nonsense: therapies for premature stop codon diseases. Trends in molecular medicine 145 23083810
2013 The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes. The EMBO journal 144 24357581
2022 MutationalPatterns: the one stop shop for the analysis of mutational processes. BMC genomics 139 35168570
2016 Stop pulling my strings - what telomeres taught us about the DNA damage response. Nature reviews. Molecular cell biology 139 27165790
2007 Green light: a signal to slow down or stop. Journal of experimental botany 137 17630292
2016 Should I stop or should I go? The role of complexin in neurotransmitter release. Nature reviews. Neuroscience 121 26806630
2004 Stop and go traffic to tune T cell responses. Immunity 120 15357942
2005 Cough and glottic-stop reflex sensitivity in health and disease. Chest 115 15705995
2018 VDAC Regulation: A Mitochondrial Target to Stop Cell Proliferation. Advances in cancer research 113 29551129
2023 Transformer for one stop interpretable cell type annotation. Nature communications 112 36641532
2018 The stop-and-go traffic regulating protein biogenesis: How translation kinetics controls proteostasis. The Journal of biological chemistry 111 30504455
2008 The reverse stop-signal model for CTLA4 function. Nature reviews. Immunology 110 18219311
2020 FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease. Nature 106 32581359
2018 Why Do Sex Chromosomes Stop Recombining? Trends in genetics : TIG 103 29716744
1994 When replication forks stop. Molecular microbiology 98 7984091
2017 Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Neuron 91 28521134
2004 Pharmacologic therapy for stop mutations: how much CFTR activity is enough? Current opinion in pulmonary medicine 85 15510065
2000 Lessons from the Stroke Prevention Trial in Sickle Cell Anemia (STOP) study. Journal of child neurology 84 10830201
2002 Non-stop decay--a new mRNA surveillance pathway. BioEssays : news and reviews in molecular, cellular and developmental biology 83 12210514
1996 Three, four or more: the translational stop signal at length. Molecular microbiology 81 8858577
2023 Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII. Molecular cell 77 36634677
2004 GABA puts a stop to pain. Current drug targets. CNS and neurological disorders 74 15578966
2017 Should We Stop Saying 'Glia' and 'Neuroinflammation'? Trends in molecular medicine 71 28499701
2022 Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus. Nature reviews. Neurology 69 35538233
1998 How protein reads the stop codon and terminates translation. Genes to cells : devoted to molecular & cellular mechanisms 65 9685178
2021 Stop helping pathogens: engineering plant susceptibility genes for durable resistance. Current opinion in biotechnology 64 34153774
2020 MAP6 is an intraluminal protein that induces neuronal microtubules to coil. Science advances 64 32270043
2019 Start-Stop Assembly: a functionally scarless DNA assembly system optimized for metabolic engineering. Nucleic acids research 62 30462270
2016 Translational termination without a stop codon. Science (New York, N.Y.) 59 27934701
2012 Cancer syndromes and therapy by stop-codon readthrough. Trends in molecular medicine 59 23044248
2015 Why does the gout attack stop? A roadmap for the immune pathogenesis of gout. RMD open 55 26557370
2020 Deciphering the molecular mechanism of stop codon readthrough. Biological reviews of the Cambridge Philosophical Society 54 33089614
2015 Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis. Proceedings of the National Academy of Sciences of the United States of America 54 25901317
2008 Crossroads of cytokine signaling--the chase to stop muscle cachexia. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 53 19261984
2016 Next stop for the CRISPR revolution: RNA-guided epigenetic regulators. The FEBS journal 51 27248712
1998 The evidence for exercise-induced inflammation in intermittent claudication: should we encourage patients to stop walking? European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 50 9518994
2012 A MAP6-related protein is present in protozoa and is involved in flagellum motility. PloS one 47 22355359
2018 When to Stop Eculizumab in Complement-Mediated Thrombotic Microangiopathies. American journal of nephrology 44 30110670
2023 Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment. Nature 43 36631608
2010 Principles of stop-codon reading on the ribosome. Nature 43 20512119
2020 Stop testing for autoantibodies to the VGKC-complex: only request LGI1 and CASPR2. Practical neurology 42 32595134
2020 ELX-02 Generates Protein via Premature Stop Codon Read-Through without Inducing Native Stop Codon Read-Through Proteins. The Journal of pharmacology and experimental therapeutics 41 32376628
2016 Evolutionary Dynamics of Abundant Stop Codon Readthrough. Molecular biology and evolution 41 27604222
2006 Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia. Schizophrenia research 40 16624526
2020 STOP floxing around: Specificity and leakiness of inducible Cre/loxP systems. European journal of immunology 39 32125704
2012 Reduced expression of STOP/MAP6 in mice leads to cognitive deficits. Schizophrenia bulletin 39 23002183
2003 Stop codon suppression via inhibition of eRF1 expression. RNA (New York, N.Y.) 39 12756323
2010 Go or stop? Divergent roles of Reelin in radial neuronal migration. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 38 20817919
2021 Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae. PLoS genetics 36 33878104
2018 Pseudouridines have context-dependent mutation and stop rates in high-throughput sequencing. RNA biology 35 29683381
2008 Activated protein C--an anticoagulant that does more than stop clots. The international journal of biochemistry & cell biology 34 18249579
2005 Polypeptide chain termination and stop codon readthrough on eukaryotic ribosomes. Reviews of physiology, biochemistry and pharmacology 34 15928926
2016 RNA folding pathways in stop motion. Nucleic acids research 33 27091499
2021 CRISPR-BETS: a base-editing design tool for generating stop codons. Plant biotechnology journal 31 34669232
2006 Altered expression of synaptic protein mRNAs in STOP (MAP6) mutant mice. Journal of psychopharmacology (Oxford, England) 31 17050659
2004 Astrocytes and oligodendrocytes express different STOP protein isoforms. Journal of neuroscience research 31 15389836
2017 Pyrrolysine Amber Stop-Codon Suppression: Development and Applications. Chembiochem : a European journal of chemical biology 30 28758366
2014 Neuronal transport defects of the MAP6 KO mouse - a model of schizophrenia - and alleviation by Epothilone D treatment, as observed using MEMRI. NeuroImage 30 24704457
2005 Dynamic protein adsorption in microchannels by "stop-flow" and continuous flow. Lab on a chip 30 16175266
1993 Transfer RNA-mediated suppression of stop codons in protoplasts and transgenic plants. Plant molecular biology 30 8343603
2020 Metabolic stress promotes stop-codon readthrough and phenotypic heterogeneity. Proceedings of the National Academy of Sciences of the United States of America 29 32839318
2019 Homozygous stop mutation in AHR causes autosomal recessive foveal hypoplasia and infantile nystagmus. Brain : a journal of neurology 29 31009037
2020 Translational read-through promotes aggregation and shapes stop codon identity. Nucleic acids research 28 32128584
1999 UGA: a dual signal for 'stop' and for recoding in protein synthesis. Biochemistry. Biokhimiia 28 10648957
1998 Directionally evolving genetic code: the UGA codon from stop to tryptophan in mitochondria. Journal of molecular evolution 28 9767683
2021 Read-through approach for stop mutations in Duchenne muscular dystrophy. An update. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 27 33870095
2011 Proliferation/Quiescence: When to start? Where to stop? What to stock? Cell division 27 22152110
2019 When to stop: an update on molecular mechanisms of floral meristem termination. Journal of experimental botany 26 30916342
1998 Genomic structure and chromosomal mapping of the mouse STOP gene (Mtap6). Biochemical and biophysical research communications 26 9501006
2023 Molecular basis of translation termination at noncanonical stop codons in human mitochondria. Science (New York, N.Y.) 25 37141370
2021 De novo stop-loss variants in CLDN11 cause hypomyelinating leukodystrophy. Brain : a journal of neurology 25 33313762
2019 Can we stop nucleoside analogues before HBsAg loss? Journal of viral hepatitis 25 30803099
2016 In vitro suppression of two different stop codons. Biotechnology and bioengineering 24 27882539
2013 Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin. The Journal of biological chemistry 24 23831686
2000 Phaco-chop versus stop-and-chop nucleotomy for phacoemulsification. Journal of cataract and refractive surgery 24 11084272
2020 How to learn to stop worrying and love environmental DNA monitoring. Aquatic ecosystem health & management 23 33364913
2018 Neural crest emigration: From start to stop. Genesis (New York, N.Y. : 2000) 22 29369490
2017 3D imaging of the brain morphology and connectivity defects in a model of psychiatric disorders: MAP6-KO mice. Scientific reports 22 28871106
2019 RefSeq curation and annotation of stop codon recoding in vertebrates. Nucleic acids research 21 30535227
2019 The elephant in the room: Why cardiologists should stop ignoring type 2 diabetes. Progress in cardiovascular diseases 21 31408637
2018 Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction. Skeletal muscle 21 30231928
2006 Is it easy to stop RNA polymerase? Cell cycle (Georgetown, Tex.) 20 16479153
2016 Familial amyloid polyneuropathy: When does it stop to be asymptomatic and need a treatment? Revue neurologique 19 27663057
2021 Eculizumab and aHUS: to stop or not. Blood 18 33956069
2012 Stop laughing! Humor perception with and without expressive suppression. Social neuroscience 18 22369232