- Length
- 153 aa
- Mass
- 16.7 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
22 papers cited in narrative
22 extracted findings
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
Parse failed — see logs
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Evidence
Reading pass · 22 per-paper findings extracted from the source corpus
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 1995 | VIP17/MAL (canine homolog of human MAL proteolipid) localizes to apical transport vesicles in MDCK cells, cycling between the Golgi complex and the apical plasma membrane, consistent with a role as a component of the vesicular trafficking machinery for apical sorting. | Immunofluorescence microscopy of epitope-tagged VIP17/MAL in BHK and MDCK cells; subcellular fractionation; biochemical enrichment in CHAPS-insoluble complexes | FEBS letters | Medium | 8549777 |
| 1995 | MVP17, the rat oligodendrocyte homolog of human MAL (88.9% identity), is expressed specifically in oligodendrocytes and brain during active myelination and is enriched in detergent-insoluble protein-lipid complexes, indicating association with glycolipid-rich microdomains during myelinogenesis. | Protein microsequencing, cDNA cloning, Northern analysis, in vitro translation, two-dimensional gel electrophoresis of detergent-insoluble fractions | Journal of neuroscience research | Medium | 8583510 |
| 1997 | MAL and caveolin occupy distinct lipid microenvironments within internal detergent-insoluble membranes of MDCK cells; MAL resides in an internal glycolipid-enriched microdomain independently of caveolin expression, demonstrating heterogeneity within the raft compartment. | Sucrose-gradient fractionation of Triton X-100 cell extracts; immunofluorescence in MDCK, Jurkat, and A498 cells; detergent-solubilization assays | Biochemical and biophysical research communications | Medium | 9168919 |
| 1997 | MAL is identified as a member of an extended gene family that includes plasmolipin, BENE, and other tetraspan proteins; the conserved fingerprint motif -[Q/Y-G-W-V-M-F/Y-V]- at the first extracellular loop/second transmembrane domain junction defines the MAL protein family. | Mouse MAL cDNA cloning and structural gene characterization; database searches and computer-aided sequence analysis; Northern blot expression analysis | Gene | Medium | 9168137 |
| 1998 | MAL associates with GPI-anchored proteins and Src-like tyrosine kinases (including Lck) in glycolipid-enriched membrane (GEM) microdomains of T lymphocytes; co-immunoprecipitation with anti-MAL and anti-CD59 antibodies demonstrated specific association in both cell lines and primary T cells, and MAL and Lck co-localize in endosomal GEM fractions. | Monoclonal antibody generation against MAL; co-immunoprecipitation; sucrose-gradient fractionation of GEM microdomains from HPB-ALL and primary human T lymphocytes | European journal of immunology | Medium | 9842910 |
| 1998 | A C-terminal tetrapeptide motif LIRW is necessary for incorporation of MAL into glycolipid-enriched membrane (GEM) microdomains; the arginine within LIRW is the most critical residue, and loss of GEM incorporation correlates with loss of brefeldin A sensitivity, linking GEM association to Golgi-dependent transport function. | Site-directed mutagenesis of MAL C-terminus; pulse-chase experiments; sucrose-gradient fractionation of GEM fractions; brefeldin A treatment | The Journal of biological chemistry | High | 9582298 |
| 1999 | MAL is necessary for both normal apical transport rate and accurate sorting of influenza virus hemagglutinin (HA) to the apical surface of MDCK cells; MAL depletion reduces HA association with GEMs, slows surface delivery, inhibits apical delivery, and causes partial basolateral missorting; these defects are rescued by ectopic MAL re-expression. | Antisense oligonucleotide-based MAL depletion; ectopic MAL expression rescue; surface biotinylation; domain-specific transport assays; monoclonal antibody to canine MAL | The Journal of cell biology | High | 10189374 |
| 1999 | Overexpression of VIP17/MAL in MDCK cells increases apical delivery and expands the apical surface domain; antisense-mediated knockdown causes Golgi accumulation and impaired apical transport of multiple apical markers (HA, clusterin/gp80, gp114, GPI-anchored protein) without affecting basolateral E-cadherin distribution, establishing MAL as a component of the apical sorting machinery that operates via sphingolipid-cholesterol rafts. | Stable over-expression and antisense RNA expression in MDCK cells; immunofluorescence; domain-selective transport assays for multiple cargo proteins | Proceedings of the National Academy of Sciences of the United States of America | High | 10339572 |
| 1999 | MAL is an itinerant protein that cycles between the trans-Golgi network (TGN) and the plasma membrane; surface-expressed MAL is rapidly internalized via an endosomal pathway requiring endosomal acidification, and approximately 30% of internalized MAL is recycled back to the TGN, consistent with a role as a reusable component of the apical transport machinery. | FLAG-epitope and O-glycosylation tag insertion into MAL extracellular loop; surface biotinylation; anti-FLAG surface binding; neuraminidase sensitivity; resialylation assays; flow cytometry; chloroquine/monensin/NH4Cl inhibition | Molecular biology of the cell | High | 10512878 |
| 2000 | MAL co-purifies with specific glycosphingolipids (galactosylceramide and sulfatide) in detergent-insoluble domains in myelin and epithelial cells, indicating a close functional association with glycosphingolipid-enriched microdomains; MAL is localized to compact myelin in the nervous system and to the apical plasma membrane in kidney and stomach epithelial cells. | Biochemical co-purification with detergent-resistant membranes; immunolocalization in multiple tissues | Progress in neurobiology | Medium | 10739088 |
| 2003 | Features required for HA apical sorting in MDCK cells differ from those required for DRM association or MAL co-precipitation; mutations in HA transmembrane residues that prevent DRM association also decrease MAL co-precipitation, but DRM association is not sufficient for apical sorting; the limited extent and timing of HA-MAL co-precipitation suggest MAL-containing vesicles are not the primary TGN-to-apical transport intermediates. | Systematic transmembrane domain mutagenesis of HA; co-immunoprecipitation with MAL; domain-selective transport assays; detergent-resistant membrane fractionation; pulse-chase analysis | Traffic (Copenhagen, Denmark) | Medium | 14617347 |
| 2003 | MAL protein is expressed with a characteristic supranuclear granular distribution in multiple types of normal human epithelial cells throughout the respiratory, gastrointestinal, and genitourinary tracts and in exocrine/endocrine glands, consistent with MAL serving as a general component of the apical sorting machinery in diverse polarized human epithelia. | Immunohistochemical survey using MAL-specific monoclonal antibody on normal and carcinoma human tissue sections | The journal of histochemistry and cytochemistry | Low | 12704214 |
| 2004 | Genetic ablation of mal in mice results in cytoplasmic inclusions in compact myelin, everted paranodal loops, and disorganized transverse bands at the paranode-axon interface; MAL loss reduces protein levels of contactin-associated protein/paranodin, NF155, and Kv1.2 in myelin-derived rafts while nodal sodium channel clusters are unaltered, demonstrating a critical role for MAL in maintenance of CNS paranodal integrity, likely by controlling trafficking/sorting of NF155 and other membrane components in oligodendrocytes. | Mal knockout mice; electron microscopy; immunofluorescence; subcellular fractionation of myelin and raft fractions; Western blot quantification of multiple myelin proteins | The Journal of cell biology | High | 15337780 |
| 2004 | MAL and Caveolin-1 co-fractionate with raft membranes and co-localize in a multivesicular intracellular compartment in PC-3 prostate cancer cells; MAL is present in prostasomes secreted by PC-3 cells, and prostasome secretion is reduced by wortmannin (PI3K inhibitor) but not brefeldin A, suggesting MAL-associated multivesicular compartments participate in PI3K-dependent prostasomal secretion rather than conventional secretory pathway. | Subcellular fractionation; immunofluorescence co-localization; prostasome isolation from conditioned medium; electron microscopy; pharmacological inhibition (brefeldin A, wortmannin) | Journal of cell science | Medium | 15466889 |
| 2004 | In metachromatic leukodystrophy (arylsulfatase A-deficient) mice, sulfatide accumulation in myelin causes a specific and severe reduction of MAL protein and mistargeting of MAL to the late endosomal/lysosomal compartment in renal epithelial cells, revealing a regulatory link between sulfatide levels and MAL expression/intracellular distribution. | Arylsulfatase A-deficient mouse model; Western blot quantification of myelin proteins; immunofluorescence and subcellular fractionation in cultured renal epithelial cells with sulfatide loading | Neurobiology of disease | Medium | 15193296 |
| 2009 | MAL forms oligomers via intramembrane protein-protein binding motifs and clusters sphingolipid raft markers while excluding phosphatidylethanolamine analogues; MAL-mediated raft lipid concentration is driven in part by positive hydrophobic mismatch between MAL transmembrane helices and membrane lipids; cholesterol and ceramide modulate MAL-raft association. | Bimolecular fluorescence complementation (BiFC) for oligomerization; spontaneous clustering via DiHcRED-MAL fusion; antibody-mediated cross-linking of FLAG-MAL; site-directed mutagenesis of intramembrane motifs; exogenous cholesterol/ceramide membrane modulation; fluorescent lipid partitioning assays in COS7 cells | Molecular biology of the cell | High | 19553470 |
| 2010 | MAL interacts with Inverted Formin 2 (INF2) and requires INF2 for the formation of MAL-positive transport vesicles carrying Lck to the plasma membrane; MAL-positive vesicles move along microtubule tracks; INF2 knockdown reduces Lck at the plasma membrane and impairs immunological synapse formation; both actin polymerization and depolymerization activities of INF2 are required; Cdc42 and Rac1 regulate Lck transport in Jurkat and primary T cells. | Co-immunoprecipitation of MAL with INF2; immunofluorescence co-localization; live videomicroscopy of MAL vesicle movement; siRNA knockdown of INF2; flow cytometry for surface Lck; immunological synapse assays; dominant-negative Cdc42/Rac1 constructs | Blood | High | 20881207 |
| 2011 | MAL accumulates at the central supramolecular activation cluster (cSMAC) of the immunological synapse, where it co-localizes with condensed (raft) membranes; mislocalization of MAL to the peripheral SMAC reduces membrane condensation at the cSMAC and redistributes microtubule/vesicle docking machinery, causing Lck and LAT to be missorted to the pSMAC while TCR sorting is unaffected, demonstrating that MAL controls membrane order and protein sorting at the immunological synapse. | Live-cell imaging of MAL-GFP during IS formation; Laurdan membrane order probe; MAL mistargeting constructs; immunofluorescence for SMAC components in Jurkat and primary T cells | Journal of immunology | High | 21508261 |
| 2011 | MAL, but not its family member MAL2, self-associates and forms higher-order cholesterol-dependent complexes with apical cargo proteins, promoting formation of detergent-resistant membranes that recruit apical proteins; this biochemical activity is consistent with a role for MAL in raft coalescence and stabilization driven by hydrophobic mismatch between MAL's long transmembrane helices and short-acyl-chain Golgi phospholipids. | Co-immunoprecipitation of MAL self-association; cholesterol depletion/replenishment; detergent-resistant membrane fractionation with apical cargo co-fractionation; comparison of MAL vs MAL2 | The Biochemical journal | Medium | 21732912 |
| 2016 | MAL is required for apical delivery of fusiform vesicles carrying uroplakins in urothelial umbrella cells; Rab27b functions upstream of MAL in the apical exocytic pathway, and MAL facilitates SNARE-mediated apical membrane fusion; keratin 20 defines a subapical compartment containing MAL-dependent fusion-primed vesicles. | Immunomicroscopy of normal and Rab27b-knockout mouse urothelia; MAL-deficient mouse model; live imaging; genetic epistasis between Rab27b and MAL | Molecular biology of the cell | High | 27009205 |
| 2019 | Clostridium perfringens epsilon toxin (ETX) binds to CNS microvasculature in a MAL-dependent manner; ETX-induced blood-brain barrier permeability via caveolae-dependent transcytosis requires expression of both MAL and caveolin-1; MAL-deficient mice show no detectable ETX binding to CNS vasculature and no BBB permeability, establishing MAL as a receptor or obligate co-factor for ETX binding on brain endothelial cells. | In vivo ETX injection in wild-type, MAL-deficient, and caveolin-1-deficient mice; fluorescent tracer extravasation assays; immunofluorescence; electron microscopy of caveolae; endosomal marker analysis in primary brain endothelial cells | PLoS pathogens | High | 31703116 |
| 2020 | MAL and PLP are exceptional among multipass transmembrane proteins in preferring ordered (raft) membrane domains; using giant plasma membrane vesicles (GPMVs), MAL showed high raft affinity among 24 multipass TMPs tested (92% had minimal raft affinity); PLP requires cholesterol and sphingolipids for raft association and appears to compete with MAL for cholesterol-mediated raft partitioning. | Giant plasma membrane vesicle (GPMV) partitioning assay; systematic comparison of 24 multipass TMPs; cholesterol/sphingolipid depletion; competition assay between MAL and PLP | The journal of physical chemistry. B | High | 32436385 |
Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | Cell | 2861 | 17081983 |
| 2007 | ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. | Science (New York, N.Y.) | 2519 | 17525332 |
| 2012 | Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. | Cell | 1718 | 22658674 |
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2006 | A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | Nature biotechnology | 1336 | 16964243 |
| 2004 | Large-scale characterization of HeLa cell nuclear phosphoproteins. | Proceedings of the National Academy of Sciences of the United States of America | 1159 | 15302935 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 2001 | Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. | Nature | 938 | 11544529 |
| 2013 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk. | Nature genetics | 895 | 23535729 |
| 2018 | VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. | Cell discovery | 829 | 29507755 |
| 1999 | The DNA sequence of human chromosome 22. | Nature | 808 | 10591208 |
| 2001 | Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. | Cell | 757 | 11439182 |
| 2003 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | Nature genetics | 754 | 14702039 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 2015 | A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. | Cell | 433 | 26638075 |
| 2022 | OpenCell: Endogenous tagging for the cartography of human cellular organization. | Science (New York, N.Y.) | 432 | 35271311 |
| 2007 | Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. | Proceedings of the National Academy of Sciences of the United States of America | 426 | 17287340 |
| 2002 | Potentiation of serum response factor activity by a family of myocardin-related transcription factors. | Proceedings of the National Academy of Sciences of the United States of America | 420 | 12397177 |
| 2009 | Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. | Nature cell biology | 355 | 19198601 |
| 2013 | Genome-wide association studies identify four ER negative-specific breast cancer risk loci. | Nature genetics | 344 | 23535733 |
| 2021 | A proximity-dependent biotinylation map of a human cell. | Nature | 339 | 34079125 |
| 2003 | Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. | Molecular and cellular biology | 252 | 12944485 |
| 2001 | Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. | Nature genetics | 240 | 11431691 |
| 2007 | Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. | The Journal of cell biology | 239 | 18056415 |
| 1969 | Chromosome micromanipulation. 3. Spindle fiber tension and the reorientation of mal-oriented chromosomes. | The Journal of cell biology | 238 | 5824068 |
| 2018 | Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. | Nature cell biology | 236 | 30038252 |
| 2015 | A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. | eLife | 198 | 26673895 |
| 2001 | Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. | Proceedings of the National Academy of Sciences of the United States of America | 187 | 11344311 |
| 1999 | VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells. | Proceedings of the National Academy of Sciences of the United States of America | 176 | 10339572 |
| 2010 | A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. | Schizophrenia research | 172 | 20889312 |
| 2001 | Mutations in the gene encoding SLURP-1 in Mal de Meleda. | Human molecular genetics | 170 | 11285253 |
| 2006 | MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. | The Journal of biological chemistry | 165 | 16439361 |
| 2004 | Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration. | Developmental cell | 152 | 15239956 |
| 1999 | The MAL proteolipid is necessary for normal apical transport and accurate sorting of the influenza virus hemagglutinin in Madin-Darby canine kidney cells. | The Journal of cell biology | 149 | 10189374 |
| 2017 | Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. | Nature structural & molecular biology | 147 | 28759049 |
| 2007 | Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. | The Journal of biological chemistry | 145 | 17947237 |
| 2015 | Amygdala-prefrontal interactions in (mal)adaptive learning. | Trends in neurosciences | 141 | 25583269 |
| 2004 | The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. | Molecular cell | 136 | 15610731 |
| 2002 | Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal? | Trends in immunology | 128 | 12072368 |
| 1989 | Molecular evolution of the telomere-associated MAL loci of Saccharomyces. | Genetics | 121 | 2548922 |
| 2011 | Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. | Proceedings of the National Academy of Sciences of the United States of America | 118 | 21873236 |
| 2004 | The raft-associated protein MAL is required for maintenance of proper axon--glia interactions in the central nervous system. | The Journal of cell biology | 118 | 15337780 |
| 1995 | Cloning and characterization of MVP17: a developmentally regulated myelin protein in oligodendrocytes. | Journal of neuroscience research | 118 | 8583510 |
| 2012 | Disconnection and reconnection: the morphological basis of (mal)adaptation to stress. | Trends in neurosciences | 109 | 23000140 |
| 2013 | CADM1 and MAL promoter methylation levels in hrHPV-positive cervical scrapes increase proportional to degree and duration of underlying cervical disease. | International journal of cancer | 107 | 23456988 |
| 1995 | VIP17/MAL, a proteolipid in apical transport vesicles. | FEBS letters | 100 | 8549777 |
| 2009 | Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. | The EMBO journal | 96 | 19574958 |
| 1999 | The MAL gene is expressed in primary mediastinal large B-cell lymphoma. | Blood | 93 | 10552968 |
| 2004 | Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line. | Journal of cell science | 92 | 15466889 |
| 2009 | Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction. | Molecular cell | 90 | 19683494 |
| 2014 | CADM1, MAL and miR124-2 methylation analysis in cervical scrapes to detect cervical and endometrial cancer. | Journal of clinical pathology | 86 | 25281766 |
| 2012 | Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed. | Journal of Alzheimer's disease : JAD | 86 | 22337830 |
| 2015 | Engineered VEGF-releasing PEG-MAL hydrogel for pancreatic islet vascularization. | Drug delivery and translational research | 85 | 25787738 |
| 2009 | Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesis. | The Journal of pathology | 85 | 19662663 |
| 2006 | MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain. | Molecular and cellular biology | 84 | 16705166 |
| 2008 | Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling. | Journal of cell science | 81 | 18334560 |
| 2009 | Guidelines for practical use of MAL-PDT in non-melanoma skin cancer. | Journal of the European Academy of Dermatology and Venereology : JEADV | 80 | 19807828 |
| 2000 | MAL, a proteolipid in glycosphingolipid enriched domains: functional implications in myelin and beyond. | Progress in neurobiology | 80 | 10739088 |
| 1999 | MAL, an integral element of the apical sorting machinery, is an itinerant protein that cycles between the trans-Golgi network and the plasma membrane. | Molecular biology of the cell | 79 | 10512878 |
| 1988 | Overproduction of MalK protein prevents expression of the Escherichia coli mal regulon. | Journal of bacteriology | 69 | 3049541 |
| 1998 | MAL, a novel integral membrane protein of human T lymphocytes, associates with glycosylphosphatidylinositol-anchored proteins and Src-like tyrosine kinases. | European journal of immunology | 65 | 9842910 |
| 2009 | MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9. | Blood | 64 | 19724058 |
| 2001 | Structural model of MalK, the ABC subunit of the maltose transporter of Escherichia coli: implications for mal gene regulation, inducer exclusion, and subunit assembly. | The Journal of biological chemistry | 63 | 11709552 |
| 2006 | Effect of postharvest storage on the expression of the apple allergen Mal d 1. | Journal of agricultural and food chemistry | 62 | 16881695 |
| 2011 | Mal mediates TLR-induced activation of CREB and expression of IL-10. | Journal of immunology (Baltimore, Md. : 1950) | 61 | 21398611 |
| 1995 | Differential expression of mal genes under cAMP and endogenous inducer control in nutrient-stressed Escherichia coli. | Molecular microbiology | 59 | 7651130 |
| 2005 | Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1. | International archives of allergy and immunology | 57 | 16293967 |
| 2005 | Genomic cloning and linkage mapping of the Mal d 1 (PR-10) gene family in apple (Malus domestica). | TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik | 56 | 15883791 |
| 2010 | Formin INF2 regulates MAL-mediated transport of Lck to the plasma membrane of human T lymphocytes. | Blood | 55 | 20881207 |
| 2021 | Probing the Extremes of Covalency in M-Al bonds: Lithium and Zinc Aluminyl Compounds. | Angewandte Chemie (International ed. in English) | 54 | 34396660 |
| 2018 | Epidemiology and Risk Factors for Cryptosporidiosis in Children From 8 Low-income Sites: Results From the MAL-ED Study. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 53 | 29701852 |
| 2008 | Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patterns. | PloS one | 53 | 18523639 |
| 2010 | IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). | The Journal of biological chemistry | 52 | 20400509 |
| 2016 | NDE1 and NDEL1 from genes to (mal)functions: parallel but distinct roles impacting on neurodevelopmental disorders and psychiatric illness. | Cellular and molecular life sciences : CMLS | 51 | 27742926 |
| 2011 | MAL protein controls protein sorting at the supramolecular activation cluster of human T lymphocytes. | Journal of immunology (Baltimore, Md. : 1950) | 51 | 21508261 |
| 2009 | Clustering and lateral concentration of raft lipids by the MAL protein. | Molecular biology of the cell | 51 | 19553470 |
| 1999 | Protease activation in apoptosis induced by MAL. | Experimental cell research | 51 | 10366425 |
| 2010 | Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer. | International journal of cancer | 47 | 19642140 |
| 2007 | The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. | Journal of leukocyte biology | 47 | 17449723 |
| 2008 | Hypermethylated MAL gene - a silent marker of early colon tumorigenesis. | Journal of translational medicine | 45 | 18346269 |
| 2010 | SLURP1 mutation-impaired T-cell activation in a family with mal de Meleda. | The British journal of dermatology | 44 | 20854438 |
| 2012 | Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers. | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc | 42 | 22899296 |
| 2010 | Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma. | Molecular cancer | 42 | 21092172 |
| 2006 | Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling. | Molecular immunology | 42 | 17161867 |
| 2003 | A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia. | The British journal of dermatology | 42 | 14674887 |
| 1997 | Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin are members of an extended gene family. | Gene | 42 | 9168137 |
| 2014 | Combined CADM1/MAL methylation and cytology testing for colposcopy triage of high-risk HPV-positive women. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology | 41 | 24962840 |
| 2004 | Specific downregulation and mistargeting of the lipid raft-associated protein MAL in a glycolipid storage disorder. | Neurobiology of disease | 41 | 15193296 |
| 2013 | Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis. | Oncogene | 40 | 23728346 |
| 1997 | Caveolin and MAL, two protein components of internal detergent-insoluble membranes, are in distinct lipid microenvironments in MDCK cells. | Biochemical and biophysical research communications | 40 | 9168919 |
| 2013 | Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer. | Oncology reports | 39 | 23381221 |
| 2009 | Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. | Molecular cancer research : MCR | 39 | 19208741 |
| 2019 | Conservation through the lens of (mal)adaptation: Concepts and meta-analysis. | Evolutionary applications | 38 | 31417615 |
| 2017 | Structure of the Major Apple Allergen Mal d 1. | Journal of agricultural and food chemistry | 37 | 28161953 |
| 2013 | Current methods for photodynamic therapy in the US: comparison of MAL/PDT and ALA/PDT. | Journal of drugs in dermatology : JDD | 36 | 23986167 |
| 2006 | Developmental expression of the SRF co-activator MAL in brain: role in regulating dendritic morphology. | Journal of neurochemistry | 36 | 16945101 |
| 2015 | CADM1 and MAL methylation status in cervical scrapes is representative of the most severe underlying lesion in women with multiple cervical biopsies. | International journal of cancer | 35 | 26219541 |
| 2013 | The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1. | The Journal of cell biology | 35 | 23940119 |
| 2010 | Characterization and expression analysis of a maltose-utilizing (MAL) cluster in Aspergillus oryzae. | Fungal genetics and biology : FG & B | 35 | 19850146 |
| 2008 | The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis. | Annals of the rheumatic diseases | 35 | 18180278 |
| 2014 | The core and conserved role of MAL is homeostatic regulation of actin levels. | Genes & development | 34 | 24831700 |
| 2019 | CADM1, MAL, and miR124 Promoter Methylation as Biomarkers of Transforming Cervical Intrapithelial Lesions. | International journal of molecular sciences | 33 | 31067838 |
| 2017 | Rotavirus Infection and Disease in a Multisite Birth Cohort: Results From the MAL-ED Study. | The Journal of infectious diseases | 32 | 28472348 |
| 2003 | Features of influenza HA required for apical sorting differ from those required for association with DRMs or MAL. | Traffic (Copenhagen, Denmark) | 32 | 14617347 |
| 2015 | Preliminary evaluation of [18F]AlF-NOTA-MAL-Cys39-exendin-4 in insulinoma with PET. | Journal of drug targeting | 31 | 25758750 |
| 1992 | Chromosome mal-orientation and reorientation during mitosis. | Cell motility and the cytoskeleton | 31 | 1423661 |
| 2017 | Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. | Proceedings of the National Academy of Sciences of the United States of America | 30 | 28739909 |
| 2004 | Characterisation of Mal d 1-related genes in Malus. | Plant molecular biology | 30 | 15604687 |
| 2003 | Expression of MAL, an integral protein component of the machinery for raft-mediated pical transport, in human epithelia. | The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society | 30 | 12704214 |
| 2019 | HSV-1/TLR9-Mediated IFNβ and TNFα Induction Is Mal-Dependent in Macrophages. | Journal of innate immunity | 29 | 31851971 |
| 2017 | Human Papillomavirus Genotypes and Methylation of CADM1, PAX1, MAL and ADCYAP1 Genes in Epithelial Ovarian Cancer Patients. | Asian Pacific journal of cancer prevention : APJCP | 28 | 28240513 |
| 2013 | TLR4-MyD88/Mal-NF-kB axis is involved in infection of HSV-2 in human cervical epithelial cells. | PloS one | 28 | 24278275 |
| 2006 | Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology | 28 | 16911365 |
| 2023 | Cancer CD39 drives metabolic adaption and mal-differentiation of CD4+ T cells in patients with non-small-cell lung cancer. | Cell death & disease | 27 | 38062068 |
| 2016 | A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling. | Immunity | 27 | 26885859 |
| 2012 | Oral exposure to Mal d 1 affects the immune response in patients with birch pollen allergy. | The Journal of allergy and clinical immunology | 27 | 22921871 |
| 1999 | Functional domain analysis of the Saccharomyces MAL-activator. | Current genetics | 27 | 10447589 |
| 2016 | MAL and TMEM220 are novel DNA methylation markers in human gastric cancer. | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals | 26 | 27329150 |
| 2011 | MAL, but not MAL2, expression promotes the formation of cholesterol-dependent membrane domains that recruit apical proteins. | The Biochemical journal | 26 | 21732912 |
| 1998 | A short peptide motif at the carboxyl terminus is required for incorporation of the integral membrane MAL protein to glycolipid-enriched membranes. | The Journal of biological chemistry | 26 | 9582298 |
| 1989 | The productive gene for alpha-H chain disease protein MAL is highly modified by insertion-deletion processes. | Journal of immunology (Baltimore, Md. : 1950) | 26 | 2555418 |
| 2019 | On The Role of Myelin and Lymphocyte Protein (MAL) In Cancer: A Puzzle With Two Faces. | Journal of Cancer | 25 | 31258734 |
| 2019 | Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. | PLoS pathogens | 25 | 31703116 |
| 1995 | Identification of Lrp-regulated genes by inverse PCR and sequencing: regulation of two mal operons of Escherichia coli by leucine-responsive regulatory protein. | Journal of bacteriology | 25 | 7751276 |
| 2020 | Myelin-Associated MAL and PLP Are Unusual among Multipass Transmembrane Proteins in Preferring Ordered Membrane Domains. | The journal of physical chemistry. B | 24 | 32436385 |
| 2016 | Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells. | Molecular biology of the cell | 24 | 27009205 |
| 2013 | Synthesis and preclinical characterization of [64Cu]NODAGA-MAL-exendin-4 with a Nε-maleoyl-L-lysyl-glycine linkage. | Nuclear medicine and biology | 24 | 23932646 |
| 1988 | Structural analysis of the 5' regions of yeast SUC genes revealed analogous palindromes in SUC, MAL and GAL. | Molecular & general genetics : MGG | 24 | 2835632 |