Affinage

MAK

Serine/threonine-protein kinase MAK · UniProt P20794

Length
623 aa
Mass
70.6 kDa
Annotated
2026-04-28
78 papers in source corpus 13 papers cited in narrative 13 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MAK is a ciliary serine/threonine kinase of the CDC2-related family that functions as a master negative regulator of ciliary length by phosphorylating multiple substrates at the ciliary tip, including IFT-74 (reducing tubulin-binding affinity to promote tubulin unloading), RP1 (limiting axonemal extension), and FAP256/CEP104 (regulating axonemal microtubule assembly) (PMID:35969738, PMID:21148103, PMID:41231942). MAK is activated through phosphorylation of its TDY activation-loop threonine by the upstream kinase CCRK, and functions cooperatively with ICK to maintain ciliary axoneme integrity in photoreceptors (PMID:16954377, PMID:39293864). Loss of MAK causes elongated cilia with accumulated intraflagellar transport proteins, progressive photoreceptor degeneration, and retinitis pigmentosa in humans, with disease-causing mutations abolishing kinase activity (PMID:21148103, PMID:21835304, PMID:21825139). Gene delivery of MAK or the functionally redundant ICK rescues ciliary length defects and retinal degeneration in patient-derived cells and animal models (PMID:34518651, PMID:39293864).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1990 High

    Identification of MAK as a novel CDC2-related serine/threonine kinase expressed predominantly in meiotic germ cells established the gene's kinase identity and pointed to a specialized role in differentiated cell types.

    Evidence cDNA cloning, sequence analysis, and Northern blot in mouse testis

    PMID:2183027

    Open questions at the time
    • No substrate or pathway identified
    • Function in non-testicular tissues unknown
  2. 1993 High

    Demonstration that MAK associates with and phosphorylates a 210 kDa protein in spermatocytes both in vitro and in vivo established that MAK functions as an active kinase with at least one endogenous substrate in germ cells.

    Evidence Immunoprecipitate kinase assay and 32Pi metabolic labeling in pachytene spermatocytes

    PMID:8321219

    Open questions at the time
    • Identity of the 210 kDa substrate unknown
    • Physiological role of this phosphorylation unclear
  3. 2002 High

    The finding that Mak-knockout mice are viable and fertile with only mild sperm motility defects redirected the field away from an essential spermatogenesis role and opened the question of MAK's primary physiological function.

    Evidence Targeted gene knockout in mice with fertility and spermatogenesis phenotyping

    PMID:11971961

    Open questions at the time
    • Non-testicular phenotypes not yet examined
    • Functional redundancy with ICK not tested
  4. 2006 High

    Reconstitution of the CCRK→MAK/MRK activation cascade, including identification of the TDY activation-loop mechanism, PP5 as opposing phosphatase, and the R-P-X-S/T-P substrate consensus, defined how MAK is activated and what it recognizes.

    Evidence In vitro kinase assay, combinatorial peptide library screening, mutagenesis, mass spectrometry

    PMID:16954377

    Open questions at the time
    • Physiological substrates matching R-P-X-S/T-P consensus not identified in vivo
    • Whether CCRK activates MAK in all tissues unknown
  5. 2010 High

    Discovery that Mak localizes to photoreceptor connecting cilia and negatively regulates ciliary length — with Mak-null retinas showing elongated cilia, IFT accumulation, and rhodopsin mislocalization — fundamentally recast MAK as a ciliary kinase, with RP1 identified as a direct phospho-substrate linking kinase activity to axonemal length control.

    Evidence Mak-null mouse model, immunohistochemistry, in vitro kinase assay, overexpression rescue

    PMID:21148103

    Open questions at the time
    • Whether RP1 phosphorylation alone accounts for length phenotype unknown
    • Mechanism of IFT accumulation not defined
  6. 2011 High

    Two studies linked MAK loss-of-function to human retinitis pigmentosa: kinase-dead missense mutations were shown to abolish catalytic activity, and an Alu insertion disrupting retinal MAK isoform splicing was identified as a disease-causing allele, establishing MAK as a retinitis pigmentosa gene requiring kinase activity for photoreceptor survival.

    Evidence In vitro kinase assay with patient mutations; iPSC-derived retinal precursor isoform analysis; immunohistochemistry of human donor retina

    PMID:21825139 PMID:21835304

    Open questions at the time
    • Natural history and genotype-phenotype correlations incompletely characterized
    • Whether cone versus rod photoreceptors are differentially affected unclear
  7. 2019 High

    Genetic epistasis in C. elegans demonstrated that the CCRK→MAK cascade controls ciliary length by regulating axonemal microtubule stability and tubulin delivery via IFT, with microtubule-destabilizing mutations and IFT mutations suppressing the elongation phenotype.

    Evidence C. elegans genetic epistasis, live imaging, suppressor analysis in AWA olfactory neurons

    PMID:30955935

    Open questions at the time
    • Direct phosphorylation target mediating microtubule stability not identified in this study
    • Whether branching versus length regulation are separable unknown
  8. 2021 Medium

    Viral delivery of retinal MAK rescued cilia length defects in patient iPSC-derived photoreceptor precursors and visual function in mak-knockdown zebrafish, providing proof-of-concept for gene therapy.

    Evidence iPSC-derived cells, viral gene delivery, zebrafish morpholino knockdown, cilia length assay

    PMID:34518651

    Open questions at the time
    • Long-term efficacy and safety of gene delivery not assessed
    • Single-lab study awaits independent replication
  9. 2022 High

    Identification of IFT-74 as a direct MAK/DYF-5 substrate whose phosphorylation reduces tubulin-binding affinity ~6-fold provided a molecular mechanism for how MAK promotes tubulin unloading at the ciliary tip to control axonemal length.

    Evidence In vitro phosphorylation assay, affinity measurements, phosphomimetic/phosphoablating IFT-74 mutations in C. elegans

    PMID:35969738

    Open questions at the time
    • Whether IFT-74 phosphorylation operates identically in mammalian photoreceptors not shown
    • Contribution of IFT-74 phosphorylation relative to RP1 phosphorylation unknown
  10. 2022 Medium

    PCARE was identified as a MAK-interacting protein at the ciliary tip, with MAK-binding motifs required for WASF3-mediated membrane expansion, suggesting MAK regulates actin-driven photoreceptor outer segment disk formation.

    Evidence Co-expression studies, deletion mutagenesis, ciliary expansion assay

    PMID:35253837

    Open questions at the time
    • Direct biochemical binding not confirmed by pulldown or co-IP
    • Whether MAK phosphorylates PCARE not tested
    • Single co-expression system without in vivo validation
  11. 2024 High

    Double knockout of Mak and Ick in mice revealed functional cooperativity between these kinases, with combined loss causing complete loss of photoreceptor ciliary axonemes and severe degeneration; Ick gene delivery and pharmacological FGFR inhibition rescued Mak-null retinal degeneration, establishing therapeutic redundancy.

    Evidence Double-knockout mouse model, subretinal gene delivery, pharmacological FGFR inhibition

    PMID:39293864

    Open questions at the time
    • Whether MAK and ICK share identical substrates or have distinct targets not resolved
    • Optimal therapeutic window for intervention not defined
  12. 2025 High

    In Chlamydomonas, CrMAK was placed downstream of the LF1/LF2/LF3 length-regulatory complex and shown to phosphorylate FAP256/CEP104, a microtubule plus-end tracking protein, whose dephosphorylation impairs ciliary assembly — adding a third identified substrate to MAK's ciliary repertoire.

    Evidence Chlamydomonas mutant analysis, in vitro kinase assay, co-immunoprecipitation, live imaging

    PMID:41231942

    Open questions at the time
    • Whether mammalian CEP104 is similarly regulated by MAK not tested
    • Structural basis for CrMAK axonemal association via C-terminal tail unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • The relative contributions of MAK's multiple substrates (IFT-74, RP1, FAP256/CEP104, PCARE) to ciliary length control and photoreceptor outer segment homeostasis remain unintegrated, and no structural model of MAK exists to explain substrate selectivity or the cooperative relationship with ICK.
  • No crystal or cryo-EM structure of MAK
  • Quantitative contribution of each substrate to ciliary length phenotype not parsed
  • Whether MAK has non-ciliary functions in retinal or other neurons remains open

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 6
Localization
GO:0005929 cilium 4 GO:0005829 cytosol 1
Pathway
GO:0005929 cilium 5 R-HSA-1852241 Organelle biogenesis and maintenance 5 R-HSA-9709957 Sensory Perception 4
Partners
CCRKFAP256ICKIFT74PCARERP1

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1990 MAK (male germ cell-associated kinase) encodes a novel serine/threonine protein kinase whose kinase domain shares ~40% identity with the cdc2-CDC28 gene family; its transcripts are expressed almost exclusively in testicular germ cells entering and after meiosis. cDNA cloning, sequence analysis, Northern blot Molecular and cellular biology High 2183027
1993 MAK protein products (66 and 60 kDa) are most abundant in late pachytene spermatocytes, localize as soluble cytoplasmic proteins, associate with a 210 kDa cellular protein, and phosphorylate this 210 kDa protein on serine and threonine residues both in vitro (immunoprecipitate kinase assay) and in vivo (32Pi labeling). Subcellular fractionation, immunoprecipitation kinase assay, [35S]methionine labeling, 32Pi metabolic labeling Molecular and cellular biology High 8321219
2006 MAK and MRK/ICK require dual phosphorylation in a TDY activation-loop motif: threonine phosphorylation (T157 in MRK) is catalyzed by CCRK (cell cycle-related kinase), while tyrosine phosphorylation is by autophosphorylation. Protein phosphatase 5 (PP5) dephosphorylates MRK at T157, acting as the opposing regulator. MRK preferentially phosphorylates R-P-X-S/T-P motifs (consensus determined by combinatorial peptide library screening), and phosphorylates the antiapoptotic protein Scythe at T1080. In vitro kinase assay, combinatorial peptide library screening, site-directed mutagenesis, mass spectrometry, co-immunoprecipitation Molecular and cellular biology High 16954377
2010 Mak localizes to the connecting cilia and outer-segment axonemes of photoreceptor cells and negatively regulates ciliary length. In Mak-null retinas, photoreceptors show elongated cilia with accumulated IFT88, IFT57, expanded Kif3a, and acetylated α-tubulin signals, and rhodopsin accumulates abnormally in cell bodies. Overexpression of RP1 (a microtubule-associated protein) induces ciliary elongation, and Mak coexpression rescues this; the RP1 N-terminal portion is phosphorylated by Mak in vitro, linking Mak kinase activity to ciliary length control. Mak-null mouse model, immunohistochemistry, in vitro kinase assay, overexpression rescue experiments Proceedings of the National Academy of Sciences of the United States of America High 21148103
2011 Missense mutations in MAK that alter conserved kinase residues abolish kinase activity as demonstrated by in vitro kinase assay, establishing that MAK kinase activity is essential for its function in photoreceptor ciliary maintenance. In vitro kinase assay with disease-causing mutants American journal of human genetics High 21835304
2011 MAK is expressed in the inner segments, cell bodies, and axons of rod and cone photoreceptors in human donor tissue. An exon 9-containing MAK isoform (also including a novel exon 12) is the predominant transcript in retinal precursor cells, and failure to switch to this isoform (caused by an Alu insertion in exon 9) results in loss of normal MAK protein and retinitis pigmentosa. Immunohistochemistry of human donor tissue, iPSC differentiation into retinal precursors, RT-PCR isoform analysis Proceedings of the National Academy of Sciences of the United States of America High 21825139
2002 MAK-deficient (Mak-/-) mice are viable and fertile with intact spermatogenesis, demonstrating that MAK is not essential for sperm formation, though Mak-/- males show mildly reduced litter sizes and reduced sperm motility in vitro. Targeted gene knockout, fertility and spermatogenesis phenotyping Molecular and cellular biology High 11971961
2019 In C. elegans, DYF-18/CCRK and DYF-5/MAK act in a kinase cascade to regulate ciliary length and branching morphology: loss of dyf-18 or dyf-5 results in dramatically elongated, unbranched AWA olfactory neuron cilia. The mechanism involves regulation of axonemal microtubule stability, as EBP-2 end-binding protein decorates axonemal microtubules along their lengths, tubulin load increases, and tubulin turnover is reduced in dyf-18 mutants. Microtubule-destabilizing tubulin mutations and IFT protein mutations that disrupt tubulin transport suppress AWA cilia elongation in dyf-18 mutants. C. elegans genetic epistasis, live imaging, IFT motor localization, genetic suppressor analysis Current biology : CB High 30955935
2022 The ciliary kinase DYF-5/MAK phosphorylates multiple sites within the tubulin-binding module of IFT-74, reducing its tubulin-binding affinity approximately sixfold and promoting tubulin unloading at the ciliary tip. Ablation or constitutive activation of IFT-74 phosphorylation abnormally elongates or shortens sensory cilia in C. elegans neurons, respectively. In vitro phosphorylation assay, affinity binding measurements, C. elegans genetic analysis with phosphomimetic/phosphoablating IFT-74 mutations Proceedings of the National Academy of Sciences of the United States of America High 35969738
2024 MAK localizes to the ciliary tip and functions as an IFT regulator cooperatively with ICK. Simultaneous disruption of Mak and Ick in mice results in loss of photoreceptor ciliary axonemes and severe retinal degeneration. CCRK kinase is identified as an upstream activator of both Mak and Ick in retinal photoreceptor cells. Gene delivery of Ick and pharmacological inhibition of FGFR (a negative regulator of Ick) ameliorate retinal degeneration in Mak-/- mice. Double-knockout mouse model, live imaging, subretinal gene delivery, pharmacological FGFR inhibition Life science alliance High 39293864
2021 Viral overexpression of the retinal MAK transgene in patient iPSC-derived photoreceptor precursor cells restores MAK transcript and protein. Overexpression of retinal MAK in patient-derived fibroblasts and mak-knockdown zebrafish restores the ability to regulate primary cilia length, and mitigates the visual defect in mak knockdown zebrafish. iPSC-derived cells, viral gene delivery, zebrafish morpholino knockdown, cilia length assay Gene therapy Medium 34518651
2022 PCARE contains evolutionary conserved binding sites for the photoreceptor kinase MAK at its C-terminal region. Deletion of the MAK-binding motifs in PCARE did not abolish ciliary localization but affected downstream WASF3-mediated ciliary tip membrane expansion, suggesting MAK interacts with PCARE to regulate actin-driven photoreceptor outer segment disk formation. Co-expression studies, deletion mutagenesis, ciliary expansion assay Human molecular genetics Medium 35253837
2025 In Chlamydomonas, CrMAK (ortholog of mammalian ICK/MAK) localizes to cilia and is enriched at the ciliary tip during active ciliary assembly. CrMAK associates with the axoneme via its C-terminal tail, acts downstream of the LF1/LF2/LF3 ciliary length-regulatory complex, and phosphorylates FAP256/CEP104 (a microtubule plus-end tracking protein). Loss of CrMAK or its kinase activity leads to aciliated cells, and dephosphorylation of FAP256/CEP104 impairs ciliary assembly. Chlamydomonas mutant analysis, in vitro kinase assay, co-immunoprecipitation, live imaging, mutagenesis Proceedings of the National Academy of Sciences of the United States of America High 41231942

Source papers

Stage 0 corpus · 78 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America 177 21825139
2010 Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proceedings of the National Academy of Sciences of the United States of America 117 21148103
1990 A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. Molecular and cellular biology 113 2183027
2011 Exome sequencing and cis-regulatory mapping identify mutations in MAK, a gene encoding a regulator of ciliary length, as a cause of retinitis pigmentosa. American journal of human genetics 89 21835304
1987 Comparison of keratin monoclonal antibodies MAK-6, AE1:AE3, and CAM-5.2. American journal of clinical pathology 79 2443001
2006 Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. Molecular and cellular biology 71 16954377
2013 HAM-2 and HAM-3 are central for the assembly of the Neurospora STRIPAK complex at the nuclear envelope and regulate nuclear accumulation of the MAP kinase MAK-1 in a MAK-2-dependent manner. Molecular microbiology 65 24028079
2012 WSC-1 and HAM-7 are MAK-1 MAP kinase pathway sensors required for cell wall integrity and hyphal fusion in Neurospora crassa. PloS one 56 22879952
1979 Mak mutants of yeast: mapping and characterization. Journal of bacteriology 55 387719
2014 Fungal communication requires the MAK-2 pathway elements STE-20 and RAS-2, the NRC-1 adapter STE-50 and the MAP kinase scaffold HAM-5. PLoS genetics 54 25411845
1993 Testis-specific mak protein kinase is expressed specifically in the meiotic phase in spermatogenesis and is associated with a 210-kilodalton cellular phosphoprotein. Molecular and cellular biology 53 8321219
2017 Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 44 28336525
2012 Circadian activation of the mitogen-activated protein kinase MAK-1 facilitates rhythms in clock-controlled genes in Neurospora crassa. Eukaryotic cell 41 23125351
2002 A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation. Molecular and cellular biology 40 11971961
2011 Autosomal recessive retinitis pigmentosa caused by mutations in the MAK gene. Investigative ophthalmology & visual science 37 22110072
2019 A CCRK and a MAK Kinase Modulate Cilia Branching and Length via Regulation of Axonemal Microtubule Dynamics in Caenorhabditis elegans. Current biology : CB 36 30955935
2003 A Mak-like kinase is a repressor of GAMYB in barley aleurone. The Plant journal : for cell and molecular biology 33 12609043
1999 Generation of phagocytic MAK and MAC-DC for therapeutic use: characterization and in vitro functional properties. Experimental hematology 29 10210333
1985 Androgen regulation of MAK mRNAs in mouse kidney. The Journal of biological chemistry 25 2410417
2007 Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression. American journal of physiology. Renal physiology 23 17299141
2022 DYF-5/MAK-dependent phosphorylation promotes ciliary tubulin unloading. Proceedings of the National Academy of Sciences of the United States of America 21 35969738
2013 Transcriptional profiling of Neurospora crassa Δmak-2 reveals that mitogen-activated protein kinase MAK-2 participates in the phosphate signaling pathway. Fungal genetics and biology : FG & B 21 23733042
1992 In situ localization of male germ cell-associated kinase (mak) mRNA in adult mouse testis: specific expression in germ cells at stages around meiotic cell division. Cell biochemistry and function 19 1473268
2015 Hunk/Mak-v is a negative regulator of intestinal cell proliferation. BMC cancer 17 25881306
2015 Identification and Characterization of MicroRNAs in Ginkgo biloba var. epiphylla Mak. PloS one 17 25978425
2014 Retinitis pigmentosa caused by mutations in the ciliary MAK gene is relatively mild and is not associated with apparent extra-ocular features. Acta ophthalmologica 16 25385675
2013 Distinct expression patterns of ICK/MAK/MOK protein kinases in the intestine implicate functional diversity. PloS one 16 24244486
2000 The MAK-V protein kinase regulates endocytosis in mouse. Molecular & general genetics : MGG 15 11129044
2015 Efficient In Silico Identification of a Common Insertion in the MAK Gene which Causes Retinitis Pigmentosa. PloS one 12 26558903
2016 Intraretinal cystoid spaces in a patient with retinitis pigmentosa due to mutation in the MAK gene. Ophthalmic genetics 9 26894652
2016 Involvement of MAK-1 and MAK-2 MAP kinases in cell wall integrity in Neurospora crassa. Bioscience, biotechnology, and biochemistry 9 27268441
2005 Cloning and sequence analysis of the 22-kDa antigen genes of Orientia tsutsugamushi strains Kato, TA763, AFSC 7, 18-032460, TH1814, and MAK 119. Annals of the New York Academy of Sciences 9 16481519
1980 Isolation and characterization of temperature-sensitive mak mutants of Saccharomyces cerevisiae. Journal of bacteriology 9 7002907
2023 MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS. Proceedings of the National Academy of Sciences of the United States of America 8 37399380
2019 Classification or non-classification of substances with positive tumor findings in animal studies: Guidance by the German MAK commission. Regulatory toxicology and pharmacology : RTP 8 31433998
2007 MAK-4 and -5 supplemented diet inhibits liver carcinogenesis in mice. BMC complementary and alternative medicine 8 17559639
1993 Retinol differentially regulates male germ cell-associated kinase (mak) messenger ribonucleic acid expression during spermatogenesis. Biology of reproduction 7 8286591
2021 Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa. Gene therapy 6 34518651
2021 Coordinated Regulation of Protoperithecium Development by MAP Kinases MAK-1 and MAK-2 in Neurospora crassa. Frontiers in microbiology 6 34899653
2021 The GUL-1 Protein Binds Multiple RNAs Involved in Cell Wall Remodeling and Affects the MAK-1 Pathway in Neurospora crassa. Frontiers in fungal biology 6 37744127
2004 Subcellular localization of MAK-V/Hunk protein kinase expressed in COS-1 cells. Cell biology international 6 14759768
1996 The antioxidant and antiatherogenic effects of MAK-4 in WHHL rabbits. Journal of alternative and complementary medicine (New York, N.Y.) 6 9395676
2024 Ccrk-Mak/Ick signaling is a ciliary transport regulator essential for retinal photoreceptor survival. Life science alliance 5 39293864
2023 Discovery and Characterization of MaK: A Novel Knottin Antimicrobial Peptide from Monochamus alternatus. International journal of molecular sciences 5 38139394
2017 High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration. American journal of ophthalmology 5 29103961
2012 Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase. PloS one 5 22745772
1991 Therapy of recurrent high-grade gliomas with surgery, autologous mitogen-activated IL-2-stimulated (MAK) killer lymphocytes, and rIL-2: II. Correlation of survival with MAK cell tumor necrosis factor production in vitro. Lymphokine and cytokine research 5 1873360
2022 PCARE requires coiled coil, RP62 kinase-binding and EVH1 domain-binding motifs for ciliary expansion. Human molecular genetics 4 35253837
2019 Plastome of mycoheterotrophic Burmannia itoana Mak. (Burmanniaceae) exhibits extensive degradation and distinct rearrangements. PeerJ 4 31608171
2018 Slowly progressive retinitis pigmentosa caused by two novel mutations in the MAK gene. Ophthalmic genetics 4 29781741
2011 Interaction between MAK-V protein kinase and synaptopodin. Biochemistry. Biokhimiia 4 21568852
2000 The Necessity of Developing New Criteria for Carcinogen Classification of Fibers by the Mak Commission. Inhalation toxicology 4 26368644
2011 Classification of skin sensitizing substances: a comparison between approaches used by the DFG-MAK Commission and the European Union legislation. Regulatory toxicology and pharmacology : RTP 3 21798301
2008 Membrane localization of the MAK-V protein kinase. Biochemistry. Biokhimiia 3 18393762
2004 MAK-5 treatment enhances the nerve growth factor-mediated neurite outgrowth in PC12 cells. Journal of ethnopharmacology 3 15234748
1999 The lack of binding of methyl-n-amyl ketone (MAK) to rat liver DNA as demonstrated by direct binding measurements, and 32P-postlabeling techniques. Mutation research 3 10393282
2025 Ellipsoid Zone Loss as an Outcome Measure in MAK-Associated Retinitis Pigmentosa. American journal of ophthalmology 2 40578471
2025 N,N',N''-Tris(β-hydroxyethyl)hexahydro-1,3,5-triazine: MAK Value Documentation, addendum - Translation of the German version from 2023. The MAK collection for occupational health and safety 2 41586737
2022 MAPK/MAK/MRK overlapping kinase mediated apoptosis through caspase signaling pathway from Cristaria plicata. Developmental and comparative immunology 2 35460761
2000 Characterization of a Mak subgroup Cdc2-like protein kinase from sugar beet (Beta vulgaris L.). Journal of experimental botany 2 11141185
2025 N,N',N''-Tris(β-hydroxypropyl)hexahydro-1,3,5-triazine: MAK Value Documentation - Translation of the German version from 2023. The MAK collection for occupational health and safety 1 41584500
2022 Downregulation of mapk/mak/mrk overlapping kinase 1 in peripheral blood mononuclear cells of pediatric patients with type 1 diabetes mellitus. Journal of medical biochemistry 1 36042901
2020 From the T-cell receptor to cancer therapy: an interview with Tak W. Mak. Cell death and differentiation 1 33335286
2017 [Survival Benefit by Combined Administration of Cyclophosphamide, Lentinula edodes Mycelia Extract(LEM), and Ganoderma lucidum Mycelia Extract(MAK)in S1018B10 Tumor-Bearing Mice]. Gan to kagaku ryoho. Cancer & chemotherapy 1 29066688
2000 [Experimental study on the influence of Gynostemma pentaphyllam Mak upon point mutation of Ha-ras oncogene in blocking leukoplakia from canceration]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 1 11780494
2026 Formononetin ameliorates SP-induced urticaria in mice via suppressing TAK1/MAK signaling pathway. PloS one 0 41575991
2026 Single-cell RNA-seq reveals a key role for Vibrio cholerae Mak toxins in Tetrahymena pyriformis killing and bacterial survival. Frontiers in microbiology 0 41657991
2025 Chlamydomonas protein kinase MAK phosphorylates FAP256/CEP104 and regulates axonemal microtubule assembly. Proceedings of the National Academy of Sciences of the United States of America 0 41231942
2025 Tetramethylol acetylenediurea: MAK Value Documentation - Translation of the German version from 2023. The MAK collection for occupational health and safety 0 41584501
2025 N,N-Dimethyl-p-toluidine: MAK Value Documentation - Translation of the German version from 2022. The MAK collection for occupational health and safety 0 41586081
2025 Naphthalene: MAK Value Documentation, addendum - Translation of the German version from 2022. The MAK collection for occupational health and safety 0 41586701
2025 Synthetic amorphous silica: MAK Value Documentation, addendum - Translation of the German version from 2023. The MAK collection for occupational health and safety 0 41971562
2025 Zinc diamyldithiocarbamate: MAK Value Documentation - Translation of the German version from 2023. The MAK collection for occupational health and safety 0 41971568
2025 Chloroform: MAK Value Documentation, addendum - Translation of the German version from 2022. The MAK collection for occupational health and safety 0 41973600
2005 [Molecular cloning and characterization of the mouse mak-v/Hunk gene promoter]. Molekuliarnaia biologiia 0 15773550
2002 [The use of the two-hybrid cloning in yeast for functional characterization of protein kinase MAK-V]. Molekuliarnaia biologiia 0 12068635
1995 Protoplast culture and plant regeneration from the suspension cells of Gynostemma pentaphyllum (Thumb) Mak. Chinese journal of biotechnology 0 8679938
1975 [Characterisation of RNA from synchronously growing yeast cells (Saccharomyces cerevisiae) as separated by columns of methylated albumin on Kieselgur (MAK) (author's transl)]. Zeitschrift fur Naturforschung. Section C, Biosciences 0 125971