LRRC23
Leucine-rich repeat-containing protein 23 · UniProt Q53EV4
- Length
- 343 aa
- Mass
- 39.8 kDa
- Annotated
- 2026-06-10
100 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 100 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1996 | CD28/B7 system of T cell costimulation. | Annual review of immunology | 2086 | 8717514 |
| 1999 | B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. | Nature medicine | 2057 | 10581077 |
| 2005 | The B7 family revisited. | Annual review of immunology | 1871 | 15771580 |
| 1995 | B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. | Cell | 1500 | 7534215 |
| 2002 | The B7-CD28 superfamily. | Nature reviews. Immunology | 1341 | 11910893 |
| 1994 | The B7 and CD28 receptor families. | Immunology today | 1282 | 7522010 |
| 1994 | Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. | The Journal of experimental medicine | 616 | 7519245 |
| 2003 | B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. | Immunity | 574 | 12818165 |
| 2016 | Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family. | Immunity | 456 | 27192563 |
| 2008 | B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. | Blood | 431 | 18223165 |
| 1998 | CD28/B7 costimulation: a review. | Critical reviews in immunology | 351 | 9784967 |
| 2003 | Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. | Cancer research | 341 | 14612546 |
| 2020 | B7-H3: An Attractive Target for Antibody-based Immunotherapy. | Clinical cancer research : an official journal of the American Association for Cancer Research | 330 | 33051306 |
| 2007 | The B7 family and cancer therapy: costimulation and coinhibition. | Clinical cancer research : an official journal of the American Association for Cancer Research | 297 | 17875755 |
| 2006 | B7-H3 and B7-H4 expression in non-small-cell lung cancer. | Lung cancer (Amsterdam, Netherlands) | 290 | 16782226 |
| 1994 | CD28-B7 interactions in T-cell activation. | Current opinion in immunology | 287 | 7522466 |
| 1993 | Functional expression of B7/BB1 on activated T lymphocytes. | The Journal of experimental medicine | 284 | 7679711 |
| 2005 | The B7 family of immune-regulatory ligands. | Genome biology | 264 | 15960813 |
| 2021 | B7-H3/CD276: An Emerging Cancer Immunotherapy. | Frontiers in immunology | 248 | 34349762 |
| 2002 | Characterization of mouse and human B7-H3 genes. | Journal of immunology (Baltimore, Md. : 1950) | 248 | 12055244 |
| 2003 | Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. | The Journal of experimental medicine | 243 | 12719480 |
| 1994 | Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. | Journal of immunology (Baltimore, Md. : 1950) | 240 | 7519638 |
| 2003 | B7-H1 pathway and its role in the evasion of tumor immunity. | Journal of molecular medicine (Berlin, Germany) | 228 | 12721664 |
| 2003 | Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. | Journal of immunology (Baltimore, Md. : 1950) | 211 | 14568939 |
| 2017 | The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7-H3. | Immunological reviews | 203 | 28258693 |
| 2017 | New B7 Family Checkpoints in Human Cancers. | Molecular cancer therapeutics | 203 | 28679835 |
| 2020 | B7-H3, a checkpoint molecule, as a target for cancer immunotherapy. | International journal of biological sciences | 193 | 32398947 |
| 2003 | Differential binding properties of B7-H1 and B7-DC to programmed death-1. | Biochemical and biophysical research communications | 181 | 12893276 |
| 2012 | Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung. | Clinical lung cancer | 168 | 22868219 |
| 2022 | Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy. | Journal of hematology & oncology | 165 | 36284349 |
| 1993 | Expression and function of B7 on human epidermal Langerhans cells. | Journal of immunology (Baltimore, Md. : 1950) | 158 | 7679425 |
| 2012 | The role of B7 family molecules in hematologic malignancy. | Blood | 151 | 23223433 |
| 2009 | Fine tuning the immune response through B7-H3 and B7-H4. | Immunological reviews | 143 | 19426220 |
| 2018 | B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity. | Clinical cancer research : an official journal of the American Association for Cancer Research | 141 | 29530936 |
| 1999 | The role of B7 costimulation in T-cell immunity. | Immunology and cell biology | 133 | 10457196 |
| 2005 | B7-H4 overexpression in ovarian tumors. | Gynecologic oncology | 128 | 16256178 |
| 2011 | B7-h2 is a costimulatory ligand for CD28 in human. | Immunity | 126 | 21530327 |
| 2017 | B7-H3 Expression in NSCLC and Its Association with B7-H4, PD-L1 and Tumor-Infiltrating Lymphocytes. | Clinical cancer research : an official journal of the American Association for Cancer Research | 121 | 28539467 |
| 2013 | Structure and T cell inhibition properties of B7 family member, B7-H3. | Structure (London, England : 1993) | 114 | 23583036 |
| 2014 | Role of podocyte B7-1 in diabetic nephropathy. | Journal of the American Society of Nephrology : JASN | 110 | 24676639 |
| 2003 | Mouse B7-H3 induces antitumor immunity. | Gene therapy | 109 | 12939639 |
| 1996 | B7-mediated costimulation and the immune response. | Blood reviews | 109 | 8813343 |
| 2005 | The B7/CD28 costimulatory family in autoimmunity. | Immunological reviews | 107 | 15790355 |
| 2010 | Clinical significance of B7-H1 and B7-1 expressions in pancreatic carcinoma. | World journal of surgery | 106 | 20145927 |
| 2009 | Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model. | International journal of oncology | 104 | 19724910 |
| 2010 | B7-h3 and its role in antitumor immunity. | Clinical & developmental immunology | 101 | 21127709 |
| 2011 | B7-H1 and B7-DC receptors of oral squamous carcinoma cells are upregulated by Porphyromonas gingivalis. | Immunobiology | 100 | 21723642 |
| 2024 | The B7:CD28 family and friends: Unraveling coinhibitory interactions. | Immunity | 99 | 38354702 |
| 1994 | Expression of functional B7 and CTLA4 on rheumatoid synovial T cells. | Journal of immunology (Baltimore, Md. : 1950) | 98 | 7517975 |
| 2005 | B7-1 and B7-2: similar costimulatory ligands with different biochemical, oligomeric and signaling properties. | Immunology letters | 94 | 16413062 |
| 2005 | B7-H3 promotes acute and chronic allograft rejection. | European journal of immunology | 88 | 15682454 |
| 1999 | Structure and evolution of the extended B7 family. | Immunology today | 88 | 10354554 |
| 2019 | B7-H4, a promising target for immunotherapy. | Cellular immunology | 82 | 31733822 |
| 1997 | Expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86) on human hepatocellular carcinoma. | Hepatology (Baltimore, Md.) | 82 | 9141426 |
| 2003 | BTLA: a new inhibitory receptor with a B7-like ligand. | Trends in immunology | 78 | 14552835 |
| 1997 | Analysis of the B7 costimulatory pathway in allograft rejection. | Transplantation | 74 | 9175811 |
| 2008 | The complex role of B7 molecules in tumor immunology. | Trends in molecular medicine | 68 | 18986838 |
| 2012 | A review of B7-H3 and B7-H4 immune molecules and their role in ovarian cancer. | Gynecologic oncology | 66 | 22910694 |
| 2006 | Immunoregulatory role of B7-H1 in chronicity of inflammatory responses. | Cellular & molecular immunology | 66 | 16893498 |
| 2014 | Structure and cancer immunotherapy of the B7 family member B7x. | Cell reports | 64 | 25437562 |
| 2014 | B7-H1 and B7-H4 expression in colorectal carcinoma: correlation with tumor FOXP3(+) regulatory T-cell infiltration. | Acta histochemica | 62 | 25053455 |
| 2006 | Generation and characterization of B7-H4/B7S1/B7x-deficient mice. | Molecular and cellular biology | 62 | 16914726 |
| 2024 | B7-H3 Inhibitors in Oncology Clinical Trials: A Review. | Journal of immunotherapy and precision oncology | 60 | 38327753 |
| 2004 | Role of B7 in T cell tolerance. | Journal of immunology (Baltimore, Md. : 1950) | 60 | 15470046 |
| 1997 | Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response. | Journal of immunology (Baltimore, Md. : 1950) | 60 | 9126967 |
| 2014 | Tissue-expressed B7-H1 critically controls intestinal inflammation. | Cell reports | 57 | 24529703 |
| 2017 | Molecular Pathways: Evaluating the Potential for B7-H4 as an Immunoregulatory Target. | Clinical cancer research : an official journal of the American Association for Cancer Research | 56 | 28325750 |
| 2000 | Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice. | Journal of immunology (Baltimore, Md. : 1950) | 56 | 10820290 |
| 2019 | Targeting B7-1 in immunotherapy. | Medicinal research reviews | 55 | 31448437 |
| 2009 | B7-H4 expression promotes tumorigenesis in ovarian cancer. | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society | 55 | 19955922 |
| 2018 | B7-H3 in tumors: friend or foe for tumor immunity? | Cancer chemotherapy and pharmacology | 50 | 29299639 |
| 2019 | Role of MYC-miR-29-B7-H3 in Medulloblastoma Growth and Angiogenesis. | Journal of clinical medicine | 47 | 31382461 |
| 2015 | Roles of coinhibitory molecules B7-H3 and B7-H4 in esophageal squamous cell carcinoma. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | 47 | 26411671 |
| 2023 | B7-H3 immunoregulatory roles in cancer. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 46 | 37196544 |
| 2018 | Negative roles of B7-H3 and B7-H4 in the microenvironment of cervical cancer. | Experimental cell research | 46 | 30099052 |
| 2013 | B7-H4 enhances oncogenicity and inhibits apoptosis in pancreatic cancer cells. | Cell and tissue research | 45 | 23660627 |
| 2019 | The CD28-B7 Family of Co-signaling Molecules. | Advances in experimental medicine and biology | 44 | 31758530 |
| 2017 | B7-H3 is related to tumor progression in ovarian cancer. | Oncology reports | 44 | 28765941 |
| 2010 | A more selective costimulatory blockade of the CD28-B7 pathway. | Transplant international : official journal of the European Society for Organ Transplantation | 44 | 20964725 |
| 1995 | Potential roles of the B7 and CD28 receptor families in autoimmunity and immune evasion. | Clinical immunology and immunopathology | 44 | 7535672 |
| 2020 | Expression and clinical significance of PD-L1, B7-H3, B7-H4 and VISTA in craniopharyngioma. | Journal for immunotherapy of cancer | 43 | 32958683 |
| 2017 | Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma. | Cell death & disease | 41 | 29235470 |
| 2013 | Overexpression of B7-H1 correlates with malignant cell proliferation in pancreatic cancer. | Oncology reports | 41 | 24378899 |
| 2014 | Abatacept in B7-1-positive proteinuric kidney disease. | The New England journal of medicine | 40 | 24670178 |
| 1999 | The modulation of B7.2 and B7.1 on B cells by immunosuppressive agents. | Clinical and experimental immunology | 40 | 10540152 |
| 2005 | Expression of B7-H1 in inflammatory renal tubular epithelial cells. | Nephron. Experimental nephrology | 38 | 16282703 |
| 2023 | B7-H3 in Brain Malignancies: Immunology and Immunotherapy. | International journal of biological sciences | 37 | 37564196 |
| 2019 | p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance. | Scientific reports | 37 | 30967582 |
| 2011 | Immunoregulatory molecule B7-H1 (CD274) contributes to skin carcinogenesis. | Cancer research | 37 | 21730022 |
| 2002 | Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells. | The Journal of experimental medicine | 37 | 11956287 |
| 2000 | Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus. | Journal of immunology (Baltimore, Md. : 1950) | 36 | 10975864 |
| 2017 | The B7 Family Member B7-H6: a New Bane of Tumor. | Pathology oncology research : POR | 35 | 29086181 |
| 2016 | B7-H3, B7-H4, Foxp3 and IL-2 expression in cervical cancer: Associations with patient outcome and clinical significance. | Oncology reports | 35 | 26848032 |
| 2005 | Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA. | Biochemical and biophysical research communications | 35 | 15781259 |
| 2006 | Significance of B7-H1 overexpression in kidney cancer. | Clinical genitourinary cancer | 34 | 17239274 |
| 1995 | CD28:B7 interactions promote T cell adhesion. | European journal of immunology | 34 | 7489747 |
| 2011 | Therapeutic targeting of B7-H1 in breast cancer. | Expert opinion on therapeutic targets | 33 | 21870995 |
| 2009 | Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells. | Journal of immunology (Baltimore, Md. : 1950) | 30 | 19234186 |
| 2024 | A B7-H4-Targeting Antibody-Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression. | Clinical cancer research : an official journal of the American Association for Cancer Research | 29 | 37882675 |
| 2022 | Pediatric medulloblastoma express immune checkpoint B7-H3. | Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico | 28 | 34988920 |
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