LNP1
Leukemia NUP98 fusion partner 1 · UniProt A1A4G5
- Length
- 178 aa
- Mass
- 21.3 kDa
- Annotated
- 2026-06-13
93 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 93 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1998 | The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation. | Molecular and cellular biology | 238 | 9418879 |
| 2022 | Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation. | Cancer discovery | 150 | 34903620 |
| 2018 | Size, Shape, and Protein Corona Determine Cellular Uptake and Removal Mechanisms of Gold Nanoparticles. | Small (Weinheim an der Bergstrasse, Germany) | 146 | 30239120 |
| 2011 | Photothermal-chemotherapy with doxorubicin-loaded hollow gold nanospheres: A platform for near-infrared light-trigged drug release. | Journal of controlled release : official journal of the Controlled Release Society | 140 | 22063003 |
| 2012 | ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p. | Nature cell biology | 127 | 22729086 |
| 2014 | Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. | Proceedings of the National Academy of Sciences of the United States of America | 108 | 25548161 |
| 2000 | The crystal structure of nitrophorin 2. A trifunctional antihemostatic protein from the saliva of Rhodnius prolixus. | The Journal of biological chemistry | 86 | 10884386 |
| 1983 | Immunological heterogeneity of carcinoembryonic antigen: immunohistochemical detection of carcinoembryonic antigen determinants in colonic tumors with monoclonal antibodies. | Cancer research | 81 | 6184153 |
| 2024 | Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation. | Circulation | 70 | 38357791 |
| 2019 | Nuclear membrane protein Lem2 regulates nuclear size through membrane flow. | Nature communications | 64 | 31015410 |
| 2019 | Extraction, purification and properties of water-soluble polysaccharides from mushroom Lepista nuda. | International journal of biological macromolecules | 61 | 30716376 |
| 1977 | Assembly of Bacillus subtilis phage phi29. 1. Mutants in the cistrons coding for the structural proteins. | European journal of biochemistry | 52 | 402269 |
| 2018 | ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. | Proceedings of the National Academy of Sciences of the United States of America | 47 | 29915089 |
| 1994 | Localization of rotavirus VP4 neutralization epitopes involved in antibody-induced conformational changes of virus structure. | Journal of virology | 44 | 7514681 |
| 2016 | The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA. | Molecular therapy : the journal of the American Society of Gene Therapy | 43 | 27633442 |
| 2005 | Strain-specific P3 of Soybean mosaic virus elicits Rsv1-mediated extreme resistance, but absence of P3 elicitor function alone is insufficient for virulence on Rsv1-genotype soybean. | Virology | 43 | 16263149 |
| 2021 | Single-cell RNA-sequencing atlas of bovine caudal intervertebral discs: Discovery of heterogeneous cell populations with distinct roles in homeostasis. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 42 | 34591994 |
| 2016 | Inner nuclear membrane protein Lem2 augments heterochromatin formation in response to nutritional conditions. | Genes to cells : devoted to molecular & cellular mechanisms | 42 | 27334362 |
| 2025 | Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Ischemic Stroke Therapy. | Advanced materials (Deerfield Beach, Fla.) | 39 | 40143778 |
| 2021 | The Destructive Tree Pathogen Phytophthora ramorum Originates from the Laurosilva Forests of East Asia. | Journal of fungi (Basel, Switzerland) | 39 | 33803849 |
| 2024 | Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors. | Journal of medicinal chemistry | 38 | 38175811 |
| 1987 | Maturation of the immune response to (4-hydroxy-3-nitrophenyl)-acetyl (NP) haptens in C57BL/6 mice. | Molecular immunology | 37 | 3614215 |
| 2023 | Microglia Exhibit Distinct Heterogeneity Rather than M1/M2 Polarization within the Early Stage of Acute Ischemic Stroke. | Aging and disease | 35 | 37199734 |
| 2015 | Characterization of cation exchanger stationary phases applied for the separations of therapeutic monoclonal antibodies. | Journal of pharmaceutical and biomedical analysis | 35 | 25890212 |
| 1995 | Endoplasmic reticulum protein Hsp47 binds specifically to the N-terminal globular domain of the amino-propeptide of the procollagen I alpha 1 (I)-chain. | Journal of cellular biochemistry | 35 | 8567753 |
| 2017 | Formation of Matricaria chamomilla extract-incorporated Ag nanoparticles and size-dependent enhanced antimicrobial property. | Journal of photochemistry and photobiology. B, Biology | 32 | 28756155 |
| 2005 | Inhibition of cellular proliferation and induction of apoptosis by curcumin in human malignant astrocytoma cell lines. | Journal of neuro-oncology | 32 | 16193380 |
| 2006 | Diadenosine and diuridine poly(borano)phosphate analogues: synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y2 receptors. | Journal of medicinal chemistry | 31 | 16539385 |
| 2020 | Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum. | Communications biology | 29 | 32483293 |
| 2019 | Spheroidization on Fructus Mori polysaccharides to enhance bioavailability and bioactivity by anti-solvent precipitation method. | Food chemistry | 28 | 31352287 |
| 2024 | Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome. | Journal of medicinal chemistry | 26 | 39574318 |
| 2018 | [Definition, description, clinicopathological features, pathogenesis and natural history of endometriosis: CNGOF-HAS Endometriosis Guidelines]. | Gynecologie, obstetrique, fertilite & senologie | 26 | 29540335 |
| 2021 | Programmed cortical ER collapse drives selective ER degradation and inheritance in yeast meiosis. | The Journal of cell biology | 24 | 34661602 |
| 2020 | Enhancement of Tetravalent Immune Responses to Highly Conserved Epitopes of a Dengue Peptide Vaccine Conjugated to Polystyrene Nanoparticles. | Vaccines | 23 | 32722368 |
| 2023 | Structure characterization and biological activities evaluation of two hetero-polysaccharides from Lepista nuda: Cell antioxidant, anticancer and immune-modulatory activities. | International journal of biological macromolecules | 22 | 37271268 |
| 1993 | Effects of irradiation on cytokine production in glioma cell lines. | Neurologia medico-chirurgica | 21 | 7506809 |
| 2020 | Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide. | Biomaterials science | 20 | 31912808 |
| 2014 | Alkylphenolic contaminants in the diet: Sparus aurata juveniles hepatic response. | General and comparative endocrinology | 18 | 24975542 |
| 2021 | Metformin-loaded lecithin nanoparticles induce colorectal cancer cytotoxicity via epigenetic modulation of noncoding RNAs. | Molecular biology reports | 17 | 34468912 |
| 2015 | Hybridization of different antisense oligonucleotides on the surface of gold nanoparticles to silence zinc metalloproteinase gene after uptake by Leishmania major. | Colloids and surfaces. B, Biointerfaces | 16 | 25835145 |
| 2015 | NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemias. | Leukemia research | 16 | 26004809 |
| 2000 | Identification of H-2K(b)-restricted T-cell epitopes within the nucleocapsid protein of Hantaan virus and establishment of cytotoxic T-cell clones. | Journal of medical virology | 16 | 10596020 |
| 2018 | Genetic heterogeneity and mutational signature in Chinese Epstein-Barr virus-positive diffuse large B-cell lymphoma. | PloS one | 15 | 30106962 |
| 2004 | High-density oligonucleotide array analysis reveals extensive differences between freshly isolated blood and hepatic natural killer cells. | European journal of immunology | 15 | 15307185 |
| 2022 | Molecular Docking and Dynamics Simulation Studies of a Dataset of NLRP3 Inflammasome Inhibitors. | Recent advances in inflammation & allergy drug discovery | 13 | 35081900 |
| 2016 | Ability of the marine bacterium Pseudomonas fluorescens BA3SM1 to counteract the toxicity of CdSe nanoparticles. | Journal of proteomics | 12 | 27523480 |
| 2008 | The evolutionarily conserved gene LNP-1 is required for synaptic vesicle trafficking and synaptic transmission. | The European journal of neuroscience | 11 | 18279315 |
| 2024 | Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium. | NPJ vaccines | 10 | 38448450 |
| 2024 | Co-encapsulation of borage seed oil and peppermint oil blends within ultrasound-assisted soy protein isolate/purity gum ultra complex nanoparticles: Fabrication, structural interaction mechanisms, and in vitro digestion studies. | Food chemistry | 10 | 39278077 |
| 2023 | MSI-XGNN: an explainable GNN computational framework integrating transcription- and methylation-level biomarkers for microsatellite instability detection. | Briefings in bioinformatics | 10 | 37833839 |
| 2021 | A novel evaluation method for Ki-67 immunostaining in paraffin-embedded tissues. | Virchows Archiv : an international journal of pathology | 10 | 33464376 |
| 2023 | Nutrient Patterns and Risk of Osteopenia in Postmenopausal Women. | Nutrients | 9 | 37049510 |
| 2022 | Identification of neuropeptides and neuropeptide receptor genes in Phauda flammans (Walker). | Scientific reports | 9 | 35701459 |
| 2021 | Nutrient patterns are associated with discordant apoB and LDL: a population-based analysis. | The British journal of nutrition | 9 | 34523396 |
| 2019 | Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective. | The Journal of steroid biochemistry and molecular biology | 9 | 30926429 |
| 2024 | High-Throughput Molecular Modeling and Evaluation of the Anti-Inflammatory Potential of Açaí Constituents against NLRP3 Inflammasome. | International journal of molecular sciences | 8 | 39125681 |
| 2019 | Efficacy of Yttrium (III) Fluoride Nanoparticles in Orthodontic Bonding. | Journal of nanoscience and nanotechnology | 8 | 30360210 |
| 2019 | Engineering of L-Plastin Peptide-Loaded Biodegradable Nanoparticles for Sustained Delivery and Suppression of Osteoclast Function In Vitro. | International journal of cell biology | 8 | 31191656 |
| 2003 | [Cloning and analysis of three genes encoding type II CHH family neuropeptides from Fennropenaeus chinensis]. | Yi chuan xue bao = Acta genetica Sinica | 8 | 14669514 |
| 2006 | Respiratory syncytial virus group A and B genotypes and disease severity among Cuban children. | Archives of medical research | 7 | 16624656 |
| 2025 | Strategic Mutations in Designer Native Peptides Combat NLRP3 Inflammasome Activation in Neurodegenerative Disorders. | Journal of medicinal chemistry | 6 | 39874459 |
| 2025 | Computational study on the mechanism of small molecules inhibiting NLRP3 with ensemble docking and molecular dynamic simulations. | BMC pharmacology & toxicology | 6 | 40033437 |
| 2021 | Establishment and genetic characterization of cell lines derived from proliferating nasal polyps and sinonasal inverted papillomas. | Scientific reports | 6 | 34429452 |
| 2003 | Variations in the Phytophthora infestans Population in Nepal as Revealed by Nuclear and Mitochondrial DNA Polymorphisms. | Phytopathology | 6 | 18943139 |
| 2025 | A Spike-Based mRNA Vaccine Encapsulated in Phospholipid 1,2-Dioleoyl-sn-Glycero-3-PhosphoEthanolamine Containing Lipid Nanoparticles Induced Potent B- and T-Cell Responses Associated with Protection Against SARS-CoV-2 Infection and COVID-19-like Symptoms in Hamsters. | Vaccines | 5 | 39852826 |
| 2021 | Hybrid multimodal contrast agent for multiscale in vivo investigation of neuroinflammation. | Nanoscale | 5 | 33555278 |
| 2012 | Natriuretic peptides in developing medaka embryos: implications in cardiac development by loss-of-function studies. | Endocrinology | 5 | 23183183 |
| 2025 | Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement. | Journal of medicinal chemistry | 4 | 41091523 |
| 2024 | Nutrient patterns and risk of diabetes mellitus type 2: a case-control study. | BMC endocrine disorders | 4 | 38229053 |
| 2012 | Assignment of the 1H NMR resonances of protein residues in close proximity to the heme of the nitrophorins: similarities and differences among the four proteins from the saliva of the adult blood-sucking insect Rhodnius prolixus. | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry | 4 | 22711329 |
| 2003 | Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes. | Journal of leukocyte biology | 4 | 14634060 |
| 2024 | Nutrient patterns in relation to insulin resistance and endothelial dysfunction in Iranian women. | Scientific reports | 3 | 38310135 |
| 2024 | Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome. | Molecular pain | 3 | 39079948 |
| 2020 | Three neuroparsin genes from oriental river prawn, Macrobrachium nipponense, involved in ovary maturation. | 3 Biotech | 3 | 33224706 |
| 2018 | [New medical treatments for painful endometriosis: CNGOF-HAS Endometriosis Guidelines]. | Gynecologie, obstetrique, fertilite & senologie | 3 | 29530558 |
| 2025 | Systemic mRNA-LNP administration in fetuses improves survival in a mouse model of spinal muscular atrophy. | Molecular therapy. Methods & clinical development | 2 | 41210168 |
| 2025 | Design of Peptide-Modified Aluminum Nanoparticles with Enhanced Antimicrobial, Antibiofilm, Antioxidant, and DNA-Cleaving Properties. | Pharmaceutics | 2 | 41304826 |
| 2024 | Evaluation of Smooth Muscle Myosin Heavy Chain Isoform Expressions in a Buried Penis. | Journal of pediatric surgery | 2 | 38631998 |
| 2023 | A prediction model for in-hospital mortality in intensive care unit patients with metastatic cancer. | Frontiers in surgery | 2 | 36793319 |
| 2023 | Yeast lunapark regulates the formation of trans-Sey1p complexes for homotypic ER membrane fusion. | iScience | 2 | 38025788 |
| 2025 | Co-Delivery of Cisplatin and Curcumin via ROS-Responsive Nanoparticles to Activate the cGAS-STING Pathway for Osteosarcoma Metalloimmunotherapy. | Advanced healthcare materials | 1 | 41334674 |
| 2024 | Nutrient patterns in relation to metabolic health status and serum levels of brain-derived neurotrophic factor (BDNF) and adropin in adults. | Scientific reports | 1 | 38409315 |
| 2026 | Human blood-brain barrier tissue model to characterize lipid nanoparticle delivery and transport mechanisms. | Biomaterials | 0 | 41950645 |
| 2026 | Rethinking interleukin-31: A neuroimmune orchestrator of itch beyond Th2 immunity. | Allergology international : official journal of the Japanese Society of Allergology | 0 | 42091372 |
| 2026 | Single-Particle Analysis of Cargo-Dependent Deformation in Lipid Nanoparticles Using Resistive Pulse Sensing: Implications for Formulation Optimization and Quality Control of mRNA Nanomedicine. | ACS applied nano materials | 0 | 42136959 |
| 2025 | Integrative genome analysis of bacteriocin-producing Lactiplantibacillus pentosus LNP1-39 and its synbiotic role in suppressing food-borne pathogens. | Folia microbiologica | 0 | 40622670 |
| 2025 | High-content phenotypic screening reveals natural product bioactives that disrupt mosquito activity, development and serotonergic signaling. | Pesticide biochemistry and physiology | 0 | 40744614 |
| 2025 | Mast cell-5-HT-HTR2A axis involvement in chronic itch induced by SADBE. | Molecular pain | 0 | 41378780 |
| 2024 | [18F]NP3-627, a Candidate PET Imaging Agent Targeting the NLRP3 Inflammasome in the Central Nervous System. | ChemMedChem | 0 | 39540320 |
| 2008 | [Expression and analysis of the nucleoprotein of paramyxovirus Tianjin strain]. | Bing du xue bao = Chinese journal of virology | 0 | 18683562 |
| 2008 | [Recombinant expression of human influenza A virus nucleocapsid protein and its antigenicity analyses]. | Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology | 0 | 19031705 |
| 2001 | Molecular epidemiology of respiratory syncytial virus. | Chinese medical journal | 0 | 11780455 |
| 2000 | Study on typing of respiratory syncytial viruses. | Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology | 0 | 11498697 |
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