Affinage

LGALS7

Galectin-7 · UniProt P47929

Round 2 corrected
Length
136 aa
Mass
15.1 kDa
Annotated
2026-04-28
74 papers in source corpus 13 papers cited in narrative 13 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Galectin-7 is a homodimeric β-galactoside-binding lectin restricted to stratified squamous epithelia that functions as a p53- and UVB-inducible intracellular pro-apoptotic effector, acting upstream of JNK activation and mitochondrial cytochrome c release to sensitize cells to apoptotic stimuli (PMID:11706006, PMID:10500176, PMID:30594507). Structurally, it adopts a conserved galectin fold with a carbohydrate-binding pocket that engages lactose, N-acetyllactosamine, and GM1 ganglioside, enabling extracellular lectin-mediated growth suppression on neuroblastoma cells (PMID:9760227, PMID:13679866). Beyond apoptosis, galectin-7 physically interacts with HMGCS1 via phenylalanine 26, forming a positive feedback loop that drives cholesterol accumulation in keratinocytes (PMID:34454908). In cancer contexts, galectin-7 overexpression promotes breast cancer metastasis to lungs and bones in vivo, and it mediates Hedgehog pathway regulation downstream of ANGPTL4 in gastric cancer cells (PMID:20382700, PMID:39369030).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1995 High

    Identification of galectin-7 as a keratinocyte-specific β-galactoside-binding lectin established its tissue restriction and non-classical secretion, defining the gene's identity and expression domain.

    Evidence cDNA cloning from keratinocyte library, 2D-PAGE, lactose-binding assay, immunolocalization, and chromosomal mapping across two independent studies

    PMID:7534301 PMID:7729568

    Open questions at the time
    • No functional role established beyond lectin activity
    • Mechanism of non-classical secretion not defined
    • Epithelial-specific transcriptional regulation not characterized
  2. 1997 Medium

    Identification of galectin-7 (PIG1) as a p53 transcriptional target linked it to the tumor suppressor network and suggested a role in apoptosis-related gene programs.

    Evidence p53-inducible expression system in colorectal carcinoma cells with serial analysis of gene expression

    PMID:9305847

    Open questions at the time
    • Galectin-7 was one of many p53-induced genes; its specific contribution to p53-mediated apoptosis was not isolated
    • Direct p53 binding to the LGALS7 promoter was not demonstrated
  3. 1998 High

    Crystal structure determination of galectin-7 in free and ligand-bound forms defined the carbohydrate-binding pocket and revealed a distinctive dimer interface, providing the structural basis for its lectin activity.

    Evidence X-ray crystallography with galactose, galactosamine, lactose, and N-acetyllactosamine co-crystals

    PMID:9760227

    Open questions at the time
    • Structure-function relationship for intracellular (non-lectin) roles not addressed
    • Dimer interface contribution to biological activity not tested by mutagenesis
  4. 1999 High

    Demonstration that UVB-induced galectin-7 upregulation directly promotes keratinocyte apoptosis established its pro-apoptotic function in an epithelial damage context, converging with its p53 regulation.

    Evidence UVB irradiation of keratinocytes, galectin-7 overexpression vector transfection with TUNEL quantification, reconstructed skin and human skin ex vivo models

    PMID:10500176

    Open questions at the time
    • Downstream apoptotic pathway mediators not identified
    • Whether lectin activity is required for apoptosis induction was not tested
  5. 2001 High

    Mechanistic dissection placed galectin-7's pro-apoptotic activity upstream of JNK activation and mitochondrial cytochrome c release, establishing it as an intracellular apoptosis amplifier independent of its extracellular lectin function.

    Evidence Stable transfection in HeLa and DLD-1 cells, caspase-3/PARP/cytochrome c/JNK assays, zVAD-fmk rescue, nuclear/cytoplasmic immunolocalization, DNA microarray

    PMID:11706006

    Open questions at the time
    • Direct molecular target linking galectin-7 to JNK activation not identified
    • Contribution of upregulated redox genes to apoptosis not functionally validated
  6. 2003 Medium

    Identification of GM1 ganglioside as an extracellular binding partner revealed a second, lectin-dependent mechanism by which galectin-7 suppresses cell growth via glycoconjugate crosslinking.

    Evidence Solid-phase binding assay for GM1, cell proliferation assay in neuroblastoma cells, competition with galectin-3

    PMID:13679866

    Open questions at the time
    • Downstream signaling from GM1 crosslinking not characterized
    • Relevance to epithelial biology versus neuroblastoma-specific effect not resolved
  7. 2010 High

    In vivo demonstration that galectin-7 overexpression promotes breast cancer metastasis revealed a context-dependent oncogenic function, contrasting with its tumor-suppressive apoptotic role in normal epithelia.

    Evidence Stable overexpression in breast cancer lines, orthotopic and systemic mouse models with quantified lung and bone metastases

    PMID:20382700

    Open questions at the time
    • Molecular mechanism underlying metastasis promotion not defined
    • Whether lectin activity or intracellular functions drive metastasis not distinguished
  8. 2018 Medium

    Loss-of-function validation confirmed galectin-7 is required for TGF-β1-induced apoptosis in airway epithelial cells via JNK, independently replicating the JNK-cytochrome c pathway placement in a non-cancer epithelial system.

    Evidence siRNA knockdown in BEAS-2B cells, western blot for Bax/Bcl-2/caspase-3/PARP/p-JNK, anisomycin rescue of JNK activity

    PMID:30594507

    Open questions at the time
    • Single cell line from a single laboratory
    • Direct physical interaction between galectin-7 and JNK pathway components not shown
  9. 2021 High

    Identification of HMGCS1 as a direct physical interactor at phenylalanine 26 revealed a non-lectin intracellular function of galectin-7 in cholesterol metabolism, expanding its roles beyond apoptosis.

    Evidence Yeast two-hybrid, SPR, co-IP, F26 mutagenesis, siRNA knockdown and overexpression with cholesterol quantification in keratinocytes

    PMID:34454908

    Open questions at the time
    • Whether the HMGCS1 interaction operates through galectin-7's carbohydrate-binding site or an independent surface not resolved
    • Physiological consequence of altered cholesterol in keratinocytes not defined in vivo
  10. 2024 Medium

    Placement of galectin-7 as a mediator of ANGPTL4-driven Hedgehog pathway modulation in gastric cancer extended its signaling repertoire to a developmental pathway in a new cancer type.

    Evidence RNA-seq, co-IP, overexpression/knockdown in gastric cancer lines, functional assays, nude mouse xenograft

    PMID:39369030

    Open questions at the time
    • Mechanism by which galectin-7 regulates Hedgehog signaling components not defined
    • Single-laboratory study without independent replication
    • Co-IP partners within the Hedgehog pathway not specified

Open questions

Synthesis pass · forward-looking unresolved questions
  • The molecular mechanism by which intracellular galectin-7 activates JNK signaling — whether through a direct protein interaction or via redox intermediaries — remains unresolved, as does the structural basis for its context-dependent switch between pro-apoptotic and pro-metastatic functions.
  • No direct binding partner linking galectin-7 to the JNK cascade has been identified
  • Structural determinants distinguishing intracellular apoptotic from extracellular lectin functions not mapped
  • In vivo role of HMGCS1 interaction in epidermal cholesterol homeostasis not validated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008289 lipid binding 4 GO:0098772 molecular function regulator activity 3
Localization
GO:0005576 extracellular region 2 GO:0005634 nucleus 1 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-1430728 Metabolism 1
Partners
HMGCS1LGALS3

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 Human galectin-7 (LGALS7) was cloned from a keratinocyte cDNA library and shown to encode a 14-kDa beta-galactoside-binding protein (IEF 17) specifically expressed in stratified squamous epithelium. The protein was partially secreted to the medium despite lacking a classical signal peptide, localized to basal keratinocytes and areas of cell-to-cell contact, and the gene was mapped to chromosome 19. cDNA cloning, two-dimensional gel electrophoresis, immunoblotting, immunofluorescence, lactose-binding assay, chromosomal mapping The Journal of biological chemistry High 7534301
1995 Galectin-7 is a 14-kDa S-lectin specifically expressed in keratinocytes at all stages of epidermal differentiation (basal and suprabasal layers). Its expression is moderately repressed by retinoic acid, consistent with a metaplasiogenic rather than a simple differentiation-stage effect. A GST fusion protein confirmed lactose-binding properties. cDNA cloning, differential hybridization, in situ hybridization, GST fusion protein lectin assay, retinoic acid treatment Developmental biology High 7729568
1997 Galectin-7 (designated PIG1, p53-induced gene 1) was identified as a transcriptional target of p53 in colorectal carcinoma cells, placing it downstream of p53 in a pathway involving redox-related gene induction preceding apoptosis. p53-inducible expression system, transcriptional profiling (serial analysis of gene expression/differential display), pharmacological and biochemical validation Nature Medium 9305847
1998 Crystal structure of human galectin-7 was determined in free form and bound to galactose, galactosamine, lactose, and N-acetyl-lactosamine at high resolution. The structure revealed a fold similar to prototype galectins-1 and -2 but with greater similarity to Gal-10; carbohydrate-binding residues are conserved but a shortened loop alters the binding pocket. Galectin-7 crystallizes as a dimer with a packing arrangement distinct from galectins-1 and -2, with implications for carbohydrate recognition. X-ray crystallography with multiple ligands Biochemistry High 9760227
1998 Galectin-7 expression is a marker of all subtypes of stratified epithelia (interfollicular epidermis, outer root sheath, esophagus, oral epithelia, cornea, thymic Hassall's corpuscles) but is absent from simple and transitional epithelia, hair matrix, sebaceous glands, and carcinoma cell lines, establishing its specific distribution and loss in malignancy. In situ hybridization, immunolabeling of human/rat/mouse tissues, rat and mouse cDNA cloning Differentiation; research in biological diversity High 9697310
1999 Galectin-7 mRNA and protein are rapidly upregulated after UVB irradiation of epidermal keratinocytes, in parallel with p53 stabilization. In reconstructed skin and human skin ex vivo, galectin-7 overexpression is associated with sunburn/apoptotic keratinocytes. Transfection of a galectin-7 expression vector significantly increased TUNEL-positive keratinocytes, demonstrating a direct pro-apoptotic role in UV-induced apoptosis. UVB irradiation, immunofluorescence, immunoblotting, TUNEL assay, galectin-7 expression vector transfection, reconstructed skin model, human skin ex vivo Proceedings of the National Academy of Sciences of the United States of America High 10500176
2001 Galectin-7 functions as an intracellular pro-apoptotic protein, acting upstream of JNK activation and mitochondrial cytochrome c release. Ectopic expression in HeLa and DLD-1 cells enhanced susceptibility to apoptosis from mechanistically distinct stimuli. Apoptosis potentiation was associated with enhanced caspase-3 activity, PARP cleavage, accelerated cytochrome c release, and up-regulated JNK activity. The pro-apoptotic effect was blocked by pan-caspase inhibitor zVAD-fmk and was not attributable to extracellular lectin activity, as galectin-7 localizes to nuclei and cytoplasm. DNA microarray analysis revealed up-regulation of redox-related genes (monoamine oxidase B, ryanodine receptor 2, glutathione S-transferase Mu 3) in galectin-7-expressing cells. Stable transfection (HeLa, DLD-1), apoptosis assays with multiple stimuli, caspase-3 activity assay, PARP cleavage, cytochrome c release, JNK activity assay, caspase inhibitor rescue, immunofluorescence localization, DNA microarray The Journal of biological chemistry High 11706006
2003 Extracellular galectin-7 binds the GM1 ganglioside sugar chain on the surface of neuroblastoma cells (SK-N-MC), acting as a lectin to reduce cell growth without classical apoptosis features. This effect was blocked by galectin-3, mechanistically resembling galectin-1's growth-suppressive activity despite structural differences. The protein exists as a homodimer capable of crosslinking cell-surface glycoconjugates. Solid-phase binding assay, cell proliferation assay, competition assay with galectin-3, serum-supplemented culture, neuroblastoma cell lines Oncogene Medium 13679866
2010 Overexpression of galectin-7 in breast cancer cells drastically increased their metastatic capacity to lungs and bones in two preclinical mouse models. This established a functional role for galectin-7 in promoting cancer metastasis in vivo, in contrast to its tumor-suppressive role in epithelial homeostasis. Stable overexpression in breast cancer cell lines, orthotopic and systemic mouse models, quantification of pulmonary metastases and osteolytic lesions, immunohistochemistry of human breast tissue The American journal of pathology High 20382700
2018 siRNA-mediated knockdown of galectin-7 in bronchial epithelial cells (BEAS-2B) abrogated TGF-β1-induced apoptosis, decreased Bax expression, increased Bcl-2, and reduced caspase-3 cleavage and PARP cleavage. Gal-7 knockdown also inhibited TGF-β1-induced JNK phosphorylation. Rescue with the JNK activator anisomycin reversed the anti-apoptotic effect of Gal-7 silencing, placing galectin-7 upstream of JNK in TGF-β1-induced apoptosis in airway epithelial cells. siRNA knockdown, flow cytometry (apoptosis), western blotting (Bcl-2, Bax, caspase-3, PARP, p-JNK), anisomycin rescue experiment Experimental cell research Medium 30594507
2021 Galectin-7 (Gal-7) physically interacts with 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) as identified by yeast two-hybrid screening and confirmed by in vitro beta-galactosidase assay, Biacore surface plasmon resonance, and co-immunoprecipitation. The interaction site on HMGCS1 was mapped to phenylalanine 26. Exogenous Gal-7 upregulates HMGCS1 expression in keratinocytes, and LGALS7 siRNA knockdown reduces HMGCS1 and cholesterol levels. HMGCS1-overexpressing cells induce Gal-7 expression in a positive feedback loop. Gal-7-mediated cholesterol elevation was blocked by wild-type but not F26-mutated HMGCS1 peptide, linking the Gal-7/HMGCS1 interaction to cellular cholesterol accumulation. Yeast two-hybrid, in vitro beta-galactosidase assay, Biacore SPR, co-immunoprecipitation, LGALS7 siRNA knockdown, HMGCS1 overexpression, cholesterol measurement, site-directed mutagenesis (F26 mutation) The Journal of investigative dermatology High 34454908
2020 NMR spectroscopy demonstrated that galectin-7 interacts with glycans on the receptor-binding domain of the SARS-CoV-2 spike protein. Complementary experiments from both the glycoprotein and lectin perspectives identified specific interacting epitopes, and 3D models of the interacting complexes were proposed. NMR spectroscopy with 15N-labeled galectin-7 and 13C-labeled RBD glycans, binding epitope mapping Angewandte Chemie (International ed. in English) Medium 32915505
2024 In gastric cancer AGS cells, ANGPTL4 overexpression upregulates LGALS7 expression, and LGALS7 acts as a downstream mediator of ANGPTL4's anticancer phenotype. LGALS7 regulates the Hedgehog signaling pathway, and co-immunoprecipitation confirmed protein-level interactions in this context. LGALS7 was shown to influence proliferation, migration, apoptosis evasion, angiogenesis, and lymphangiogenesis downstream of ANGPTL4. RNA-seq, PCR, western blotting, co-immunoprecipitation, cell line overexpression/knockdown (SNU5, MKN7, AGS), functional assays (EdU, MTT, flow cytometry, wound healing, transwell, tube formation), nude mouse xenograft Scientific reports Medium 39369030

Source papers

Stage 0 corpus · 74 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1997 A model for p53-induced apoptosis. Nature 2186 9305847
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2010 Network organization of the human autophagy system. Nature 1286 20562859
2009 Defining the human deubiquitinating enzyme interaction landscape. Cell 1282 19615732
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
1996 Normalization and subtraction: two approaches to facilitate gene discovery. Genome research 401 8889548
2010 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell 318 21145461
2016 A High-Density Map for Navigating the Human Polycomb Complexome. Cell reports 216 27705803
2015 A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. eLife 198 26673895
2020 Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Nature cell biology 194 32203420
2001 Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. The Journal of biological chemistry 173 11706006
1999 Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. Proceedings of the National Academy of Sciences of the United States of America 173 10500176
1998 Structural basis for the recognition of carbohydrates by human galectin-7. Biochemistry 154 9760227
1995 Cloning, expression, and chromosome mapping of human galectin-7. The Journal of biological chemistry 142 7534301
1998 Galectin-7, a marker of all types of stratified epithelia. Differentiation; research in biological diversity 136 9697310
2016 SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. Molecular cell 134 27591049
2003 Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells. Oncogene 134 13679866
2014 The central role of EED in the orchestration of polycomb group complexes. Nature communications 131 24457600
1992 Strand-selective repair of DNA damage in the yeast GAL7 gene requires RNA polymerase II. The Journal of biological chemistry 115 1429664
2011 An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Stem cells (Dayton, Ohio) 113 21319273
2021 FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2. Molecular cancer 106 33658012
1985 Primary structure of the Saccharomyces cerevisiae GAL7 gene. Yeast (Chichester, England) 102 2851900
1995 Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. Developmental biology 99 7729568
2019 LUCAT1 promotes colorectal cancer tumorigenesis by targeting the ribosomal protein L40-MDM2-p53 pathway through binding with UBA52. Cancer science 93 30690837
1998 Poly(A) signals control both transcriptional termination and initiation between the tandem GAL10 and GAL7 genes of Saccharomyces cerevisiae. The EMBO journal 93 9707436
2018 Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. EMBO reports 92 29467282
2017 CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. Nucleic acids research 91 28977666
2020 Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. Angewandte Chemie (International ed. in English) 86 32915505
1988 Yeast regulatory gene GAL3: carbon regulation; UASGal elements in common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; encoded protein strikingly similar to yeast and Escherichia coli galactokinases. Molecular and cellular biology 84 3062381
2004 Interaction between transcription elongation factors and mRNA 3'-end formation at the Saccharomyces cerevisiae GAL10-GAL7 locus. The Journal of biological chemistry 83 15531585
2006 The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions. Development (Cambridge, England) 82 16774992
2014 Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation. Cell reports 80 24981860
2010 Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells. The American journal of pathology 80 20382700
2014 hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. Nucleic acids research 78 25324306
2000 Balancing transcriptional interference and initiation on the GAL7 promoter of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America 70 10890898
1995 The Cryptococcus neoformans GAL7 gene and its use as an inducible promoter. Molecular microbiology 61 8577246
1986 Duplicate upstream activating sequences in the promoter region of the Saccharomyces cerevisiae GAL7 gene. Molecular and cellular biology 58 3023825
1990 Signal sequence for generation of mRNA 3' end in the Saccharomyces cerevisiae GAL7 gene. The EMBO journal 53 2209557
1998 Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity. The Journal of antibiotics 42 9918396
1983 Nucleotide sequence of the transcriptional initiation region of the yeast GAL7 gene. Nucleic acids research 40 6324089
2002 Lactose metabolism and cellulase production in Hypocrea jecorina: the gal7 gene, encoding galactose-1-phosphate uridylyltransferase, is essential for growth on galactose but not for cellulase induction. Molecular genetics and genomics : MGG 37 11919723
2017 Epigenetic modifier induced enhancement of fumiquinazoline C production in Aspergillus fumigatus (GA-L7): an endophytic fungus from Grewia asiatica L. AMB Express 31 28213885
1985 A region flanking the GAL7 gene and a binding site for GAL4 protein as upstream activating sequences in yeast. Journal of molecular biology 30 3912516
1987 Transcription of multiple copies of the yeast GAL7 gene is limited by specific factors in addition to GAL4. Molecular & general genetics : MGG 29 3302604
1984 Expression of the Saccharomyces cerevisiae GAL7 gene on autonomous plasmids. Molecular and cellular biology 26 6390184
1997 Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p. Yeast (Chichester, England) 25 9046081
1993 A transcriptional switch between the Pig-1 and Sgs-4 genes of Drosophila melanogaster. Molecular and cellular biology 24 8417325
1997 Constitutive expression in gal7 mutants of Kluyveromyces lactis is due to internal production of galactose as an inducer of the Gal/Lac regulon. Molecular and cellular biology 22 9032299
1991 Polymerase chain reaction mapping of yeast GAL7 mRNA polyadenylation sites demonstrates that 3' end processing in vitro faithfully reproduces the 3' ends observed in vivo. Nucleic acids research 22 1677180
1992 Unusual aspects of in vitro RNA processing in the 3' regions of the GAL1, GAL7, and GAL10 genes in Saccharomyces cerevisiae. Molecular and cellular biology 21 1406619
2023 Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes. Journal of cellular and molecular medicine 18 36924030
2020 PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning. PLoS genetics 15 32946434
2018 Silencing of Gal-7 inhibits TGF-β1-induced apoptosis of human airway epithelial cells through JNK signaling pathway. Experimental cell research 12 30594507
2017 Caenorhabditis elegans CES-1 Snail Represses pig-1 MELK Expression To Control Asymmetric Cell Division. Genetics 12 28652378
2023 Deciphering the Role of PIG1 and DHN-Melanin in Scedosporium apiospermum Conidia. Journal of fungi (Basel, Switzerland) 9 36836250
2018 The kinases PIG-1 and PAR-1 act in redundant pathways to regulate asymmetric division in the EMS blastomere of C. elegans. Developmental biology 7 30213539
2016 Expression of Sialyl Lewis a, Sialyl Lewis x, Lewis y, Gal-3, Gal-7, STMN1 and p16 in cervical dysplasia. Future oncology (London, England) 7 27646625
1991 Molecular organization of the Drosophila melanogaster Pig-1 gene. Chromosoma 7 1769273
2021 Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes. The Journal of investigative dermatology 5 34454908
2011 The GAL10 gene is located 40 kbp away from the GAL7-GAL1 region in the yeast Kazachstania naganishii. Current microbiology 4 21822965
2024 SIRT7 Inhibits Melanin Synthesis of PIG1 and PIG3V by Suppressing the Succinylation of EZR. Clinical, cosmetic and investigational dermatology 3 38933605
2024 ANGPTL4 plays a paradoxical role in gastric cancer through the LGALS7 and Hedgehog pathways. Scientific reports 3 39369030
1998 The transcriptional switch between the Drosophila genes Pig-1 and Sgs-4 depends on a SEBP1 binding site within a shared enhancer region. Molecular & general genetics : MGG 3 9819059
1997 Enhancement of recombinant glucoamylase expression by introducing yeast GAL7 mRNA termination sequence. Journal of biotechnology 3 9226959
1995 Sequence and functional analysis of a 7.2 kb fragment of Saccharomyces cerevisiae chromosome II including GAL7 and GAL10 and a new essential open reading frame. Yeast (Chichester, England) 3 7762304
2025 Novel GAL7-targeted fluorescent molecular imaging probe for high-grade squamous intraepithelial lesion and cervical cancer screening. EJNMMI research 2 40082314
2024 NMY-2, TOE-2 and PIG-1 regulate Caenorhabditis elegans asymmetric cell divisions. PloS one 1 38787850
2012 Mutagenic Inverted Repeats Assisted Genome Engineering (MIRAGE) in Saccharomyces cerevisiae: deletion of gal7. Methods in molecular biology (Clifton, N.J.) 1 22144353
2025 HSV-1 inhibits melanogenesis of PIG1 cells through downregulation of VN1R5/ERK pathway. Archives of dermatological research 0 39912936
2025 M6A-METTL3-dependent nuclear PANC754/PSPC1/H3K4me1 repression complex regulate immune evasive LGALS7 signal to enhance immunotherapy against colorectal cancer. Cell death & disease 0 40634299
2022 Human Galectin-7 Gene LGALS7 Promoter Sequence Polymorphisms and Risk of Spontaneous Intracerebral Hemorrhage: A Prospective Study. Frontiers in molecular neuroscience 0 35401111