Affinage

LEF1

Lymphoid enhancer-binding factor 1 · UniProt Q9UJU2

Length
399 aa
Mass
44.2 kDa
Annotated
2026-06-10
100 papers in source corpus 38 papers cited in narrative 38 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LEF1 is an HMG-box DNA-binding transcription factor that serves as a nuclear effector of Wnt/β-catenin signaling, directing context-specific transcriptional programs across organogenesis, hematopoiesis, immunity, and cancer (PMID:11445543, PMID:15545629, PMID:30630973). Its HMG domain mediates sequence-specific promoter occupancy, and its β-catenin-binding domain determines cell-fate output: β-catenin-competent LEF1 drives hair differentiation and Wnt target activation whereas β-catenin-binding-deficient or N-terminally truncated forms redirect lineage decisions toward sebocytes and osteoblasts (PMID:11445543, PMID:19650108). LEF1 directly binds and activates a broad set of target promoters — Dll1 linking Wnt to Notch in somitogenesis, the androgen receptor, tyrosinase (synergizing with MITF), ID1, DCLK1-B, and CCND1 — and represses CYLD, whose derepression upon LEF1 dissociation triggers caspase-8-dependent apoptosis (PMID:15545629, PMID:19351848, PMID:26580798, PMID:31296250, PMID:30446587, PMID:34001852, PMID:24577083). In T cells LEF1 (with TCF1) carries intrinsic histone deacetylase activity required to silence lineage-inappropriate genes and, more broadly, enforces three-dimensional genome organization and promoter–enhancer hubs that maintain T-cell identity, regulatory T-cell function, and memory programs (PMID:27111144, PMID:34615872, PMID:30837262, PMID:36484736). LEF1 partners beyond β-catenin to diversify its outputs, interacting with homeodomain proteins Alx4 and PITX2, the methyltransferase PRMT6, the transcription factor Zeb1, and the matrix protein asporin to drive β-catenin-independent transcription (PMID:11696550, PMID:17785445, PMID:34001852, PMID:29903919, PMID:34127813). LEF1 itself is regulated at every level: transcriptionally by MYC, SNAIL1, BMP2/Runx2-driven alternative promoter usage, and Sox2-mediated repression; post-transcriptionally by IRES-mediated translation under a Bcr-Abl/mTOR/eIF4A axis, CELF2-controlled alternative splicing, miR-34a, and METTL3-dependent m6A methylation; and post-translationally by Nrarp-mediated protection from ubiquitination (PMID:31623618, PMID:31463973, PMID:19650108, PMID:24487391, PMID:25392452, PMID:21444716, PMID:25587085, PMID:31253399, PMID:16228014). In tumorigenesis its role is context-dependent — promoting prostate, gastric, and colorectal cancer phenotypes yet acting as a negative-feedback suppressor of intestinal adenoma dedifferentiation — and its DNA-binding domain has been exploited for targeted degradation by oligonucleotide PROTACs (PMID:19351848, PMID:34127813, PMID:31463973, PMID:34788095, PMID:34397171).

Mechanistic history

Synthesis pass · year-by-year structured walk · 24 steps
  1. 1996 High

    Established LEF1 as an essential epithelial mediator of inductive tissue interactions during organogenesis, placing it downstream of BMP signaling.

    Evidence Tissue recombination of Lef1-null embryos and BMP-4 treatment in tooth and whisker systems

    PMID:8647435

    Open questions at the time
    • Direct target genes mediating the inductive signal not identified
    • Relationship to Wnt/β-catenin not yet addressed
  2. 1998 Medium

    Linked LEF1 to β-catenin and upstream ILK/ECM signaling, showing LEF1/β-catenin complex formation drives nuclear β-catenin and transcription.

    Evidence Co-IP, Western blot, and invasion assays in intestinal and mammary epithelial cells

    PMID:9539744

    Open questions at the time
    • Direct transcriptional targets not defined
    • Single-lab cell-line system
  3. 2001 High

    Demonstrated that LEF1's β-catenin interaction status dictates cell-fate decisions and that homeodomain partners confer tissue specificity.

    Evidence Transgenic mouse domain-deletion (ΔNLef1) constructs; Co-IP/EMSA/reporter with Alx4

    PMID:11445543 PMID:11696550

    Open questions at the time
    • Genome-wide target repertoire of β-catenin-independent LEF1 not mapped
    • Mechanism of partner selection in vivo unresolved
  4. 2004 High

    Showed LEF1 directly bridges Wnt to Notch signaling by transcriptionally activating Dll1 in somitogenesis.

    Evidence ChIP, promoter mutagenesis in Dll1-LacZ transgenic mice, inducible LEF1-β-catenin in fibroblasts

    PMID:15545629

    Open questions at the time
    • Cooperating factors at the Dll1 promoter not defined
  5. 2005 High

    Identified LEF1 as an epithelial survival factor acting upstream of FGF signaling, explaining the developmental arrest phenotype.

    Evidence Lef1 KO mouse, TUNEL, lineage tracing, FGF4 rescue in tooth development

    PMID:15649466

    Open questions at the time
    • Direct anti-apoptotic LEF1 targets not identified
    • Connection between LEF1 and FGF4 transcription not mapped
  6. 2005 High

    Defined a post-translational control point for LEF1 abundance via Nrarp-mediated protection from ubiquitination.

    Evidence Zebrafish morpholino knockdown, ubiquitination assay, Co-IP in neural crest development

    PMID:16228014

    Open questions at the time
    • E3 ligase responsible for LEF1 ubiquitination not identified
    • Whether Nrarp acts directly on LEF1 or via adaptors unclear
  7. 2007 Medium

    Established LEF1 as a decisive transcriptional regulator of neutrophil granulopoiesis controlling proliferation and differentiation genes.

    Evidence Patient myeloid progenitor analysis and ELA2 promoter binding in severe congenital neutropenia

    PMID:17360796

    Open questions at the time
    • Limited methodological detail in abstract
    • Direct versus indirect regulation of listed targets not fully resolved
  8. 2007 High

    Revealed reciprocal regulation between LEF1 and PITX2, with simultaneous tripartite assembly of LEF1, PITX2, and β-catenin.

    Evidence ChIP, reporter assays, reciprocal Co-IP with domain mapping, transgenic Lef1-LacZ

    PMID:17785445

    Open questions at the time
    • In vivo relevance of the tripartite complex to specific developmental loci unresolved
  9. 2009 High

    Implicated LEF1 in cancer by direct activation of the androgen receptor promoter driving prostate cancer growth and invasion.

    Evidence ChIP, EMSA, reporter, siRNA knockdown and overexpression in androgen-independent prostate cancer cells

    PMID:19351848

    Open questions at the time
    • Upstream control of LEF1 in this context not addressed
  10. 2009 Medium

    Showed isoform-specific promoter usage (Lef1ΔN via the p2 promoter) under BMP2/Runx2 control redirects LEF1 toward osteoblast differentiation.

    Evidence Promoter reporter, Runx2 KD/OE, stable Lef1ΔN overexpression in osteoblasts

    PMID:19650108

    Open questions at the time
    • Endogenous Lef1ΔN target gene repertoire not defined
    • β-catenin dependence of Lef1ΔN not directly tested here
  11. 2011 High

    Identified CELF2-mediated signal-dependent alternative splicing of LEF1 exon 6 as a regulator of TCR-α expression in thymocytes.

    Evidence CELF2 knockdown, splice-blocking oligos, RNA-IP, RT-PCR, functional TCR-α readout

    PMID:21444716

    Open questions at the time
    • Functional consequence of exon 6 inclusion on LEF1 protein activity not fully defined
  12. 2014 High

    Established translational control of LEF1 via a 5'UTR IRES regulated by a Bcr-Abl/mTOR/eIF4A axis in CML.

    Evidence IRES reporters, polyribosome fractionation, PP242 and hippuristanol inhibition, primary CML cells

    PMID:25392452

    Open questions at the time
    • IRES trans-acting factors beyond eIF4A not enumerated
  13. 2014 Medium

    Defined LEF1 as a transcriptional repressor of CYLD, linking its dissociation to caspase-8-dependent apoptosis in colorectal cancer.

    Evidence ChIP, siRNA knockdown, Western blot, xenograft with IHC under selenite treatment

    PMID:24577083

    Open questions at the time
    • Mechanism driving LEF1 dissociation upon selenite not defined
    • Co-repressors at the CYLD promoter not identified
  14. 2015 Medium

    Mapped two layers of LEF1 control in cancer: miR-34a 3'UTR repression governing EMT, and direct LEF1/MITF synergy at the tyrosinase promoter.

    Evidence Luciferase 3'UTR reporter and invasion assays; ChIP/EMSA and reporter at TYR core sequence

    PMID:25587085 PMID:26580798

    Open questions at the time
    • In vivo relevance of miR-34a–LEF1 axis not established
    • Structural basis of LEF1/MITF cooperativity unknown
  15. 2016 High

    Discovered an intrinsic HDAC activity in TCF1/LEF1 required to silence lineage-inappropriate genes, expanding LEF1 beyond a DNA-binding scaffold.

    Evidence In vitro HDAC assay, 5-aa domain mutagenesis, histone acetylation profiling, conditional KO

    PMID:27111144

    Open questions at the time
    • Structural identity of the catalytic site not resolved
    • Substrate specificity beyond bulk histone acetylation not mapped
  16. 2016 High

    Showed gene-specific coactivators (Sp5/Sp8) recruit β-catenin to chromatin-bound LEF1, and Sox2 directly represses Lef1 transcription, defining input control of LEF1 activity.

    Evidence ChIP-seq, Co-IP, enhancer reporters; Sox2 ChIP/EMSA/reporter and conditional deletion in airway epithelium

    PMID:24487391 PMID:26969725

    Open questions at the time
    • Generality of Sp5/Sp8 feed-forward loop across LEF1 targets unclear
  17. 2019 High

    Identified multiple new upstream regulators (MYC, SNAIL1, METTL3 m6A) that converge on LEF1 to sustain Wnt/β-catenin output and cancer phenotypes.

    Evidence ChIP-seq (MYC), CRISPR KO and β-catenin-binding mutant (SNAIL1), m6A assay and rescue (METTL3) in colon, colorectal and osteosarcoma cells

    PMID:31253399 PMID:31463973 PMID:31623618

    Open questions at the time
    • Relative contribution of each input in a single cellular context not compared
    • m6A reader mediating METTL3 effect not identified
  18. 2019 High

    Defined LEF1 as a driver of β-catenin nuclear localization in leukemia, formalizing its role in nucleating Wnt-responsive transcription.

    Evidence Nuclear/cytoplasmic fractionation, β-catenin interactome MS, KD/OE, primary AML blasts

    PMID:30630973

    Open questions at the time
    • Mechanism by which LEF1 retains β-catenin nuclear not structurally resolved
  19. 2019 Medium

    Established β-catenin-independent partnerships (Zeb1, ASPN) that redirect LEF1 to non-canonical invasion and stemness gene programs.

    Evidence Zeb1/Lef1 ChIP-seq in glioblastoma; ASPN-LEF1 Co-IP, ChIP and reporters at PTGS2/IL6/WISP1 and ID1 in gastric and esophageal cancers

    PMID:29903919 PMID:31296250 PMID:34127813

    Open questions at the time
    • How partner binding overrides β-catenin requirement mechanistically unclear
    • Direct versus indirect recruitment in some cases not fully separated
  20. 2019 Medium

    Extended LEF1 function in immunity to regulatory T-cell suppression and to inhibition of HTLV-1 Tax-dependent viral transcription.

    Evidence Treg-specific Tcf1/Lef1 double KO with Tcf1 ChIP-seq; Tax Co-IP and viral LTR/NF-κB/AP-1 reporter assays

    PMID:25646419 PMID:30837262

    Open questions at the time
    • Lef1-specific (vs Tcf1) contributions not always separated
    • Direct chromatin targets in Tregs are mostly Tcf1 ChIP-derived
  21. 2021 High

    Demonstrated LEF1 enforces 3D genome architecture and that it recruits PRMT6 to the CCND1 promoter, broadening its chromatin-organizing and cofactor-recruiting roles.

    Evidence Hi-C, ATAC-seq, Tcf1 ChIP-seq in CD8+ T cells; LEF1-PRMT6 Co-IP and ChIP at CCND1

    PMID:34001852 PMID:34615872

    Open questions at the time
    • Direct DNA-contact contribution of LEF1 versus TCF1 to genome folding not isolated
  22. 2021 High

    Revealed a context-dependent tumor-suppressive negative-feedback role for ectopic LEF1 in Apc-mutant intestinal adenomas, complicating its oncogenic portrait.

    Evidence Conditional Lef1 deletion in Apc-mutant mouse intestine with tumor and proliferation quantification

    PMID:34788095

    Open questions at the time
    • Molecular basis of the negative feedback (target genes) not fully defined
  23. 2021 Medium

    Provided a therapeutic strategy by exploiting LEF1's DNA-binding domain for oligonucleotide-PROTAC-mediated degradation.

    Evidence O'PROTAC degradation and ubiquitination assays, reporter, xenograft

    PMID:34397171

    Open questions at the time
    • In vivo delivery and selectivity not fully characterized
    • Off-target effects on other HMG factors not assessed
  24. 2023 Medium

    Showed LEF1 drives central memory and anti-exhaustion programs in NKT cells, with translational value for adoptive cell therapy.

    Evidence CRISPR KO and overexpression, Wnt3a treatment, transcriptional profiling, CAR-NKT xenograft

    PMID:36484736

    Open questions at the time
    • Direct LEF1 targets driving the memory program not mapped

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how LEF1's many regulatory inputs and partner-dependent target repertoires are integrated to produce its opposing pro- and anti-tumorigenic and developmental outcomes within a single cell.
  • No unified structural model linking partner selection to target choice
  • Determinants of activator-versus-repressor and β-catenin-dependent-versus-independent modes undefined
  • Isoform functional distinctions (long/short, ΔN) not mechanistically resolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 6 GO:0140110 transcription regulator activity 5 GO:0060090 molecular adaptor activity 3 GO:0016787 hydrolase activity 1 GO:0140096 catalytic activity, acting on a protein 1
Localization
GO:0005634 nucleus 2 GO:0000228 nuclear chromosome 1
Pathway
R-HSA-1266738 Developmental Biology 5 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 4 R-HSA-168256 Immune System 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-4839726 Chromatin organization 2
Partners
ALX4ASPNCTNNB1FOXP3PITX2PRMT6SP5ZEB1

Evidence

Reading pass · 38 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 Integrin-linked kinase (ILK) overexpression promotes formation of a complex between β-catenin and LEF-1, leading to nuclear translocation of β-catenin and transcriptional activation by the LEF-1/β-catenin complex; LEF-1 protein levels are upregulated by ILK overexpression and rapidly modulated by cell detachment from extracellular matrix. Co-immunoprecipitation, Western blotting, invasion assays, overexpression in intestinal and mammary epithelial cells Proceedings of the National Academy of Sciences of the United States of America Medium 9539744
1996 BMP-4 can activate Lef1 gene expression, and Lef1 expression in epithelium is required for transmission of inductive signals between epithelial and mesenchymal tissues during tooth and whisker organogenesis, as shown by tissue recombination experiments with Lef1-deficient embryos. Tissue recombination of normal and Lef1-null embryos, BMP-4 treatment, targeted gene inactivation Genes & development High 8647435
2001 Lef1 requires Wnt signaling and stabilized β-catenin to activate hair-specific keratin genes and control hair differentiation; its HMG DNA-binding domain mediates these effects. A β-catenin-binding-domain-deleted Lef1 (ΔNLef1) instead promotes sebocyte differentiation rather than hair differentiation, demonstrating that Lef1's role in cell-fate decisions in multipotent skin stem cells depends on its β-catenin interaction status. Transgenic mouse overexpression, domain-deletion constructs (ΔNLef1), histological and gene expression analysis Genes & development High 11445543
2001 LEF-1 physically interacts with the paired-like homeodomain protein Alx4 through Alx4's proline-rich N-terminal domain and LEF-1's HMG-box DNA-binding domain; LEF-1 and Alx4 can bind simultaneously to adjacent sites on the N-CAM promoter and alter its activity, providing a mechanism for mesenchymal-specific LEF-1 activity. Co-immunoprecipitation, pulldown assays, electrophoretic mobility shift assay (EMSA), luciferase reporter assay, domain-deletion analysis The Journal of biological chemistry High 11696550
2004 LEF1 directly binds multiple sites in the Dll1 (Delta-like 1) promoter in vitro and in vivo, and LEF1-binding site mutations in the Dll1-LacZ transgene impair its expression in presomitic mesoderm; induced LEF1-β-catenin expression activates endogenous Dll1, establishing that Wnt/LEF1 signaling links to Notch signaling via direct transcriptional regulation of Dll1 in somitogenesis. Chromatin immunoprecipitation (ChIP), in vitro DNA binding, Dll1-LacZ transgenic reporter with LEF1-site mutations, conditional LEF1-β-catenin induction in fibroblasts Genes & development High 15545629
2005 Loss of Lef1 in mice causes significantly increased apoptosis specifically within the dental epithelium (not mesenchyme), arresting tooth development at the bud stage; FGF4 treatment inhibits apoptosis and rescues tooth development in Lef1-null mice, identifying LEF1 as a critical epithelial survival factor acting upstream of FGF signaling in tooth morphogenesis. Lef1 knockout mouse analysis, TUNEL apoptosis assay, Wnt1-Cre/R26R cell-lineage tracing, FGF4 rescue experiment Developmental biology High 15649466
2005 Nrarp stabilizes LEF1 protein by blocking its ubiquitination; Nrarp knockdown in zebrafish phenocopies lef1 knockdown in neural-crest-cell development, and Nrarp independently regulates LEF1 protein turnover (Wnt pathway) separately from its regulation of Notch signaling. Antisense morpholino knockdown in zebrafish, ubiquitination assay, co-immunoprecipitation, Western blotting Nature cell biology High 16228014
2007 LEF1 is a decisive transcription factor in neutrophil granulopoiesis, controlling proliferation, lineage commitment, and granulocytic differentiation by directly regulating target genes C/EBP-α, cyclin D1, c-myc, survivin, and the ELA2 (neutrophil elastase) promoter; myeloid progenitors from severe congenital neutropenia patients show severe downregulation of LEF1 and its targets. Gene expression analysis in primary patient cells, promoter binding assays (ELA2 promoter), functional studies in myeloid progenitors Annals of the New York Academy of Sciences Medium 17360796
2007 PITX2 isoforms directly regulate the LEF1 promoter (identified by ChIP); β-catenin synergistically enhances LEF1 promoter activation in combination with PITX2 and Lef1. PITX2 interacts with Lef1 at two sites (the β-catenin-binding domain is dispensable), while β-catenin binds the PITX2 homeodomain and Lef1 binds the PITX2 C-terminal tail; all three proteins can interact simultaneously. Chromatin immunoprecipitation (ChIP), luciferase reporter assay, co-immunoprecipitation, domain-deletion analysis, transgenic mouse Lef1-LacZ reporter Molecular and cellular biology High 17785445
2009 LEF1 occupies and activates the androgen receptor (AR) promoter in prostate cancer cells; LEF1 overexpression increases AR expression and enhances growth and invasion, while LEF1 knockdown decreases AR expression and reduces growth and invasion in androgen-independent prostate cancer cells. Chromatin immunoprecipitation (ChIP), gel shift (EMSA), luciferase reporter assay, siRNA knockdown, overexpression Cancer research High 19351848
2009 BMP2 stimulates expression of a naturally occurring N-terminally truncated Lef1 isoform (Lef1ΔN) driven by an alternative promoter (p2) within intron 3-4 of Lef1, while Wnt3a blocks this expression; Runx2 regulates the p2 promoter activity; stable overexpression of Lef1ΔN in osteoblasts induces osteocalcin and type 1 collagen, promoting terminal differentiation. Promoter reporter assays, Runx2 knockdown/overexpression, stable overexpression of Lef1ΔN, RT-PCR, gene expression analysis Journal of cellular physiology Medium 19650108
2011 The splicing factor CELF2 controls signal-dependent alternative splicing of LEF1 exon 6 by binding two intronic sequences flanking the regulated exon; inclusion of exon 6 is required for optimal TCR-α chain mRNA expression during thymic development and upon T-cell signaling. siRNA knockdown of CELF2, splice-site blocking oligonucleotides, RT-PCR isoform analysis, RNA immunoprecipitation, functional readout of TCR-α expression Molecular and cellular biology High 21444716
2014 LEF-1 translation is regulated by an IRES in its 5' UTR; the LEF1 IRES recruits eIF4A and is controlled by a Bcr-Abl–mTOR–eIF4A axis in CML cells. Inhibition of mTOR (PP242) or eIF4A (hippuristanol) suppresses IRES-mediated LEF1 translation and triggers dissociation of LEF1 mRNA from polyribosomes. IRES reporter assays, polyribosome fractionation, pharmacological inhibition with PP242 and hippuristanol, primary patient CML cell analysis Open biology High 25392452
2014 LEF1 directly binds to the CYLD promoter and suppresses CYLD transcription; upon selenite treatment, LEF1 dissociates from the CYLD promoter, relieving suppression of CYLD (a deubiquitinase), leading to removal of K63-linked ubiquitin chains from RIP1, formation of a death-inducing complex, and caspase-8-dependent apoptosis in colorectal cancer cells. Chromatin immunoprecipitation (ChIP), siRNA knockdown, Western blotting, xenograft model with immunohistochemistry Cell death & disease Medium 24577083
2015 miR-34a directly targets the 3'-UTR of LEF1 mRNA to repress its expression, and this miR-34a-LEF1 axis regulates epithelial-mesenchymal transition (EMT), migration, and invasion of prostate cancer cells; luciferase reporter assays confirmed direct 3'-UTR binding. Luciferase reporter assay with LEF1 3'-UTR, miR-34a overexpression/inhibition, migration and invasion assays Molecular cancer research : MCR Medium 25587085
2015 LEF1 directly regulates tyrosinase (TYR) gene transcription; LEF1 binds to the core GTTTGAT sequence (-56 to -50) in the TYR promoter as shown by ChIP and EMSA; LEF1 and MITF synergistically transactivate the TYR promoter. Luciferase reporter assay, siRNA knockdown, ChIP, promoter deletion/mutation analysis, EMSA (implied by 'LEF-1 interacts with TYR promoter') PloS one Medium 26580798
2016 Tcf1 and Lef1 possess intrinsic histone deacetylase (HDAC) activity; mutation of five conserved amino acids in the Tcf1 HDAC domain diminishes HDAC activity and impairs suppression of CD4+ lineage genes in CD8+ T cells; Tcf1/Lef1-deficient CD8+ T cells exhibit histone hyperacetylation at lineage-inappropriate loci. HDAC activity assay, domain mutagenesis (5-aa mutation), histone acetylation profiling, conditional knockout mouse model, gene expression analysis Nature immunology High 27111144
2016 Sp5 and Sp8 bind directly to GC boxes in Wnt target gene enhancers and interact with chromatin-bound Tcf1/Lef1 to facilitate recruitment of β-catenin to select target gene enhancers, acting as gene-specific transcriptional coactivators in a feed-forward loop. ChIP-seq in mouse embryos and ESCs, co-immunoprecipitation, enhancer reporter assays, double-mutant genetic analysis Proceedings of the National Academy of Sciences of the United States of America Medium 26969725
2016 Sox2 acts as a transcriptional repressor that directly binds a functional site in the Lef-1 promoter and suppresses β-catenin-dependent Lef-1 transcription; ChIP and DNA-protein binding (EMSA) confirmed Sox2 occupancy; suppression of Sox2 in SMG placodes relieves repression and enables Wnt-induced Lef-1 expression during submucosal gland morphogenesis. ChIP, EMSA/DNA-protein binding, luciferase reporter assay with promoter mutation, conditional Sox2 deletion, primary airway epithelial cultures American journal of physiology. Lung cellular and molecular physiology High 24487391
2019 The m6A methyltransferase METTL3 promotes LEF1 mRNA m6A methylation and increases LEF1 total mRNA levels; METTL3 silencing decreases LEF1 m6A methylation and mRNA level, reduces Wnt/β-catenin signaling activity, and impairs osteosarcoma cell proliferation/invasion; LEF1 overexpression abrogates METTL3 silencing effects. Lentiviral METTL3 silencing, m6A methylation assay, RT-PCR, rescue overexpression of LEF1, functional proliferation/invasion assays Biochemical and biophysical research communications Medium 31253399
2019 LEF-1 drives nuclear localization of β-catenin in myeloid leukemia cells; nuclear LEF-1 and β-catenin levels are tightly correlated; LEF-1 knockdown perturbs β-catenin nuclear localization and transcriptional activation, while LEF-1 overexpression promotes nuclear β-catenin accumulation and Wnt-responsive transcription in previously Wnt-unresponsive cells. Nuclear/cytoplasmic proteomic fractionation, β-catenin interactome by mass spectrometry, LEF-1 knockdown and overexpression, reporter assays, primary AML blast analysis Haematologica High 30630973
2019 MYC directly activates LEF1 transcription (ChIP-seq confirms MYC occupancy at LEF1 locus); MYC-induced LEF1 causes retention of β-catenin in the nucleus activating the Wnt pathway; LEF1 is required for MYC-induced expression of PPARδ and ACAD9; LEF1 is required for viability of MYC-expressing colon cancer cells. RNA-seq, ChIP-seq, RT-qPCR, Western blotting, siRNA knockdown, metabolomics Cell communication and signaling : CCS Medium 31623618
2019 TCF1/LEF1 interact with HTLV-1 Tax protein and inhibit Tax-dependent viral gene expression, NF-κB activation, and AP-1 activation; HTLV-1 replication is suppressed in the presence of TCF1 or LEF1; T-cell activation suppresses TCF1/LEF1 expression, enabling Tax function. Co-immunoprecipitation, reporter assays (NF-κB, AP-1, viral LTR), TCF1/LEF1 overexpression, T-cell activation experiments, STLV-1-infected macaque thymus analysis Proceedings of the National Academy of Sciences of the United States of America Medium 25646419
2019 SNAIL1 upregulates LEF1 expression; LEF1 knockout (CRISPR/Cas9) and expression of a β-catenin-binding-deficient LEF1 mutant both impair SNAIL1-induced alternative Wnt/β-catenin target gene expression and cancer cell invasion; LEF1 accounts for ~35% of SNAIL1-induced transcriptional changes in colorectal cancer cells, acting as a strictly β-catenin-dependent downstream effector of SNAIL1. CRISPR/Cas9 LEF1 knockout, LEF1 β-catenin-binding mutant engineering, conditional SNAIL1 expression, transcriptome analysis, invasion assay, xenotransplantation International journal of cancer High 31463973
2019 Mutant Lef1 (β-catenin-independent) transcriptionally activates Gata6 independently of β-catenin; Gata6 ablation in mutant Lef1-overexpressing mice decreases the proportion of sebaceous gland tumors while increasing total tumor burden and correlating with impaired DNA mismatch repair (decreased Mlh1, Msh2). Transgenic mouse models (mutant Lef1 overexpression, Gata6 conditional KO), in utero lentiviral Gata6 overexpression, gene expression analysis, tumor phenotyping The EMBO journal Medium 30886049
2019 Tcf1 and Lef1 are required for immunosuppressive function of regulatory T cells; Tcf1/Lef1-deficient Tregs show reduced expression of signature genes (Ikzf4, Izumo1r) and aberrant upregulation of cytotoxic CD8+ effector genes (Prdm1, Ifng); Tcf1 ChIP-seq reveals co-occupancy of Tcf1 and Foxp3 at key Treg signature and cytotoxic effector gene loci. Conditional Treg-specific Tcf1/Lef1 double KO, transcriptomic analysis, Tcf1 ChIP-seq, colitis protection assay, autoimmunity phenotyping The Journal of experimental medicine High 30837262
2019 Asporin (ASPN) directly binds LEF1 and promotes LEF1-mediated transcriptional activation of PTGS2, IL6, and WISP1 promoters independently of β-catenin; ASPN-mediated suppression of gastric cancer cell apoptosis is abolished by LEF1 knockdown or PTGS2 inhibition. Co-immunoprecipitation (ASPN-LEF1 interaction), ChIP (LEF1 promoter occupancy at PTGS2, IL6, WISP1), luciferase reporter assay, siRNA knockdown, overexpression rescue Oncogene Medium 34127813
2021 Tcf1 and Lef1 maintain three-dimensional genome organization in mature CD8+ T cells at multiple scales; Tcf1 directly enforces chromatin interactions and accessibility, promoting formation of interconnected hubs for T cell identity gene promoter–enhancer contacts and repression of non-T lineage genes. Hi-C (chromosome conformation capture), ATAC-seq (chromatin accessibility), Tcf1 ChIP-seq, conditional ablation of Tcf1/Lef1 in mature CD8+ T cells, transcriptomics Nature communications High 34615872
2021 LEF1 recruits PRMT6 (protein arginine methyltransferase 6) to the CCND1 (cyclin D1) promoter; LEF1 knockdown reduces cyclin D1 expression; PRMT6 knockdown increases G1 cell cycle arrest and decreases proliferation. Co-immunoprecipitation (LEF1-PRMT6 interaction), ChIP (LEF1/PRMT6 at CCND1 promoter), siRNA knockdown, cell cycle analysis Oncogenesis Medium 34001852
2021 Oligonucleotide-based PROTACs (O'PROTACs) incorporating LEF1-binding double-stranded DNA sequences can induce proteasomal degradation of LEF1 protein via E3 ubiquitin ligase recruitment, impeding LEF1 transcriptional activity and inhibiting cancer cell growth in vitro and in vivo. O'PROTAC protein degradation assay, ubiquitination assay, transcriptional activity reporter, cell viability and xenograft tumor growth assays Advanced science (Weinheim, Baden-Wurttemberg, Germany) Medium 34397171
2021 Loss of Lef1 in Apc-mutant intestinal adenomas markedly increases tumor initiation and cell proliferation, reduces Wnt antagonist expression, increases Myc expression, and promotes ectopic crypt formation, revealing a negative feedback role for ectopic Lef1 that suppresses intestinal tumorigenesis by restricting adenoma cell dedifferentiation. Conditional Lef1 deletion in intestinal stem cells of Apc-mutant mice, tumor burden and proliferation quantification, gene expression analysis Science advances High 34788095
2019 Zeb1 is indirectly recruited to regulatory regions of glioblastoma target genes via interaction with Lef1 (Wnt pathway effector), resulting in transcriptional activation independently of Wnt signaling; this Zeb1/Lef1 co-regulatory mechanism activates invasion-promoting genes including Prex1. Genome-wide Zeb1 ChIP-seq, transcriptomics in glioblastoma stem-like cells, Lef1 ChIP-seq, overexpression and knockdown, in vivo invasion assay The EMBO journal Medium 29903919
2016 Lef1-expressing fibroblasts in neonatal papillary dermis constitute a transient regenerative cell type; gain-of-function Lef1 expression in adult dermal fibroblasts primes the skin macroenvironment to enhance repair and regeneration of hair follicles with arrector pili muscles, while loss-of-function Lef1 deletion impairs this regenerative capacity. scRNA-seq, gain-of-function and loss-of-function genetic mouse models for Lef1 in fibroblasts, wound healing assays, histological analysis eLife Medium 32990218
2023 LEF1 overexpression in NKT cells drives a central memory transcriptional program, promoting CD62L+ frequency and NKT expansion while limiting exhaustion; CRISPR/Cas9-mediated LEF1 knockout reduces CD62L+ frequency after stimulation; LEF1-expressing CAR-NKTs show superior neuroblastoma tumor control in vivo. CRISPR/Cas9 LEF1 knockout, LEF1 overexpression, Wnt3a ligand treatment, transcriptional profiling, xenograft tumor model Cancer immunology research Medium 36484736
2019 LEF1 inhibition decreases DCLK1-B expression by blocking LEF1 binding to the DCLK1-B promoter in colorectal cancer cells; LEF1/DCLK1-B axis regulates cancer stemness and self-renewal; niclosamide blocks LEF1-DCLK1-B promoter binding and eradicates cancer stem-like cells. ChIP (LEF1 occupancy at DCLK1-B promoter), siRNA/shRNA knockdown, luciferase reporter, sphere formation assays, xenograft model Clinical cancer research : an official journal of the American Association for Cancer Research Medium 30446587
2019 LEF1 directly activates transcription of the TGF-β pathway gene ID1 by binding to its promoter in esophageal squamous cell carcinoma; ASPN-mediated LEF1-ID1 activation promotes cancer stem cell-like properties and tumorigenicity. Luciferase reporter assay, ChIP-qPCR (LEF1 binding at ID1 promoter), RNA-seq, siRNA knockdown Journal of experimental & clinical cancer research : CR Medium 31296250
2021 β-catenin/LEF1 complex directly binds the IGF-IIR promoter (putative LEF1 consensus site identified) and activates IGF-IIR expression under Ang-II-induced hypertensive conditions in cardiac cells, promoting cardiac hypertrophy. Luciferase reporter assay, immunoprecipitation, nuclear-cytosolic protein fractionation, Western blot in H9c2 cells and SHR rat tissue International journal of molecular sciences Low 31480672
2023 Differential expression of long and short LEF1 isoforms is a key regulatory mechanism of cellular senescence; LEF1 dysregulation is associated with idiopathic pulmonary fibrosis; this isoform balance was identified computationally and validated in cell culture and human lung tissue. Transcriptome comparative analysis, cell culture senescence assays, RT-qPCR in human lung tissue samples, computational transcriptional network analysis Aging cell Low 37961030

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes & development 442 11445543
1998 Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proceedings of the National Academy of Sciences of the United States of America 388 9539744
1996 Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. Genes & development 352 8647435
2016 Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. Nature immunology 189 27111144
2004 LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes & development 155 15545629
2020 Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds. eLife 139 32990218
2000 Induction of lef1 during zebrafish fin regeneration. Developmental dynamics : an official publication of the American Association of Anatomists 122 11002347
2019 The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1. Biochemical and biophysical research communications 117 31253399
2021 Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 106 34397171
2010 Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood 96 20124220
2005 LEF1 is a critical epithelial survival factor during tooth morphogenesis. Developmental biology 95 15649466
2019 TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell reports 94 31216480
2019 Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. The Journal of experimental medicine 90 30837262
2009 LEF1 in androgen-independent prostate cancer: regulation of androgen receptor expression, prostate cancer growth, and invasion. Cancer research 87 19351848
2015 LEF1 Targeting EMT in Prostate Cancer Invasion Is Regulated by miR-34a. Molecular cancer research : MCR 83 25587085
2011 Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching. Pigment cell & melanoma research 80 21599871
2005 Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Nature cell biology 72 16228014
2007 PITX2 and beta-catenin interactions regulate Lef-1 isoform expression. Molecular and cellular biology 71 17785445
2021 Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture. Nature communications 70 34615872
2019 Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation. Cell communication and signaling : CCS 69 31623618
2018 Inhibition of LEF1-Mediated DCLK1 by Niclosamide Attenuates Colorectal Cancer Stemness. Clinical cancer research : an official journal of the American Association for Cancer Research 59 30446587
2014 From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells. Immunologic research 59 24847765
2004 Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation. Histopathology 59 15569047
2019 Knockdown of lncRNA LEF1-AS1 inhibited the progression of oral squamous cell carcinoma (OSCC) via Hippo signaling pathway. Cancer biology & therapy 58 30983488
2016 Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development (Cambridge, England) 55 27660324
2016 Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proceedings of the National Academy of Sciences of the United States of America 54 26969725
1999 Maternal and embryonic expression of zebrafish lef1. Mechanisms of development 50 10446273
2021 Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients. Molecular psychiatry 48 33398088
2018 Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion. The EMBO journal 47 29903919
2017 LEF1, TFE3, and AR are putative diagnostic markers of solid pseudopapillary neoplasms. Oncotarget 47 29212159
2020 Pitx2-Sox2-Lef1 interactions specify progenitor oral/dental epithelial cell signaling centers. Development (Cambridge, England) 45 32439755
2015 Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia. PloS one 45 25942645
2013 Increased LEF1 expression and decreased Notch2 expression are strong predictors of poor outcomes in colorectal cancer patients. Disease markers 45 24223455
2001 Alx4 binding to LEF-1 regulates N-CAM promoter activity. The Journal of biological chemistry 45 11696550
2011 Signal- and development-dependent alternative splicing of LEF1 in T cells is controlled by CELF2. Molecular and cellular biology 44 21444716
2005 Wnt pathway component LEF1 mediates tumor cell invasion and is expressed in human and murine breast cancers lacking ErbB2 (her-2/neu) overexpression. International journal of oncology 43 16142310
2019 LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells. Haematologica 42 30630973
2019 SNAIL1 employs β-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation. International journal of cancer 41 31463973
2014 LEF1 regulates glioblastoma cell proliferation, migration, invasion, and cancer stem-like cell self-renewal. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 41 25128061
2019 DC-SIGN-LEF1/TCF1-miR-185 feedback loop promotes colorectal cancer invasion and metastasis. Cell death and differentiation 40 31217502
2019 The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma. Journal of experimental & clinical cancer research : CR 40 31296250
2012 The role of LEF1 in endometrial gland formation and carcinogenesis. PloS one 40 22792274
2024 TCF1-LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases. Nature immunology 39 38589618
2020 Quercetin Inhibits Lef1 and Resensitizes Docetaxel-Resistant Breast Cancer Cells. Molecules (Basel, Switzerland) 38 32492961
2016 Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors. The Journal of biological chemistry 37 27044748
2019 Long noncoding RNA LEF1-AS1 silencing suppresses the initiation and development of prostate cancer by acting as a molecular sponge of miR-330-5p via LEF1 repression. Journal of cellular physiology 36 30613973
2009 Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation. Journal of cellular physiology 33 19650108
2020 LEF1-AS1 accelerates tumorigenesis in glioma by sponging miR-489-3p to enhance HIGD1A. Cell death & disease 32 32826866
2014 The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells. Cell death & disease 32 24577083
2019 LncRNA LEF1-AS1 regulates the migration and proliferation of vascular smooth muscle cells by targeting miR-544a/PTEN axis. Journal of cellular biochemistry 31 31016789
2017 LEF1-AS1, a long-noncoding RNA, promotes malignancy in glioblastoma. OncoTargets and therapy 31 28894380
2019 LEF1-AS1 contributes to proliferation and invasion through regulating miR-544a/ FOXP1 axis in lung cancer. Investigational new drugs 29 30734202
2021 Striking Association of Lymphoid Enhancing Factor (LEF1) Overexpression and DUSP22 Rearrangements in Anaplastic Large Cell Lymphoma. The American journal of surgical pathology 28 33165091
2021 LEF1 silencing sensitizes colorectal cancer cells to oxaliplatin, 5-FU, and irinotecan. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 28 34474344
2019 lncRNA LEF1-AS1 Promotes Malignancy in Non-Small-Cell Lung Cancer by Modulating the miR-489/SOX4 Axis. DNA and cell biology 28 31386568
2017 Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS biology 27 28837622
2021 PRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1. Oncogenesis 26 34001852
2020 Long noncoding RNA LEF1-AS1 binds with HNRNPL to boost the proliferation, migration, and invasion in osteosarcoma by enhancing the mRNA stability of LEF1. Journal of cellular biochemistry 25 31930565
2020 Silencing of long noncoding RNA LEF1-AS1 prevents the progression of hepatocellular carcinoma via the crosstalk with microRNA-136-5p/WNK1. Journal of cellular physiology 25 32068261
2020 LncRNA LEF1-AS1 Promotes Ovarian Cancer Development Through Interacting with miR-1285-3p. Cancer management and research 25 32099465
2020 Long noncoding RNA LEF1-AS1 acts as a microRNA-10a-5p regulator to enhance MSI1 expression and promote chemoresistance in hepatocellular carcinoma cells through activating AKT signaling pathway. Journal of cellular biochemistry 25 32786108
2020 Cinobufagin Suppresses Melanoma Cell Growth by Inhibiting LEF1. International journal of molecular sciences 25 32933177
2019 LEF1-AS1, long non-coding RNA, inhibits proliferation in myeloid malignancy. Journal of cellular and molecular medicine 25 30770626
2018 CDX2 and LEF-1 expression in pilomatrical tumors and their utility in the diagnosis of pilomatrical carcinoma. Journal of cutaneous pathology 25 29369390
2023 The β-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance. Journal of experimental & clinical cancer research : CR 24 37106379
2015 TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax. Proceedings of the National Academy of Sciences of the United States of America 24 25646419
2021 Asporin represses gastric cancer apoptosis via activating LEF1-mediated gene transcription independent of β-catenin. Oncogene 23 34127813
2019 Mutant Lef1 controls Gata6 in sebaceous gland development and cancer. The EMBO journal 23 30886049
2023 LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells. Cancer immunology research 22 36484736
2023 Dermal PapillaCell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1. International journal of molecular sciences 22 36835374
2021 LEF1 Enhances the Progression of Colonic Adenocarcinoma via Remodeling the Cell Motility Associated Structures. International journal of molecular sciences 22 34639214
2017 Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal. Biology open 22 28288968
2014 A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. Open biology 22 25392452
2020 Long Non-Coding RNA LEF1-AS1 Promotes Migration, Invasion and Metastasis of Colon Cancer Cells Through miR-30-5p/SOX9 Axis. OncoTargets and therapy 21 32308428
2020 LncRNA LEF1-AS1 promotes osteogenic differentiation of dental pulp stem cells via sponging miR-24-3p. Molecular and cellular biochemistry 21 32780211
2015 LEF-1 Regulates Tyrosinase Gene Transcription In Vitro. PloS one 21 26580798
2014 Sox2 modulates Lef-1 expression during airway submucosal gland development. American journal of physiology. Lung cellular and molecular physiology 21 24487391
2022 Long Non-Coding LEF1-AS1 Sponge miR-5100 Regulates Apoptosis and Autophagy in Gastric Cancer Cells via the miR-5100/DEK/AMPK-mTOR Axis. International journal of molecular sciences 20 35563178
2021 LncRNA LEF1-AS1/LEF1/FUT8 Axis Mediates Colorectal Cancer Progression by Regulating α1, 6-Fucosylationvia Wnt/β-Catenin Pathway. Digestive diseases and sciences 20 34021424
2011 5-aza-2'-deoxycytidine enhances susceptibility of renal cell carcinoma to paclitaxel by decreasing LEF1/phospho-β-catenin expression. Cancer letters 20 21880414
2019 Differences in expression and function of LEF1 isoforms in normal versus leukemic hematopoiesis. Leukemia 19 31758089
2021 Knockdown of long non-coding RNA LEF1-AS1 attenuates apoptosis and inflammatory injury of microglia cells following spinal cord injury. Journal of orthopaedic surgery and research 18 33407665
2020 LncRNA LEF1-AS1 silencing diminishes EZH2 expression to delay hepatocellular carcinoma development by impairing CEBPB-interaction with CDCA7. Cell cycle (Georgetown, Tex.) 18 32178558
2020 CREB1-induced lncRNA LEF1-AS1 contributes to colorectal cancer progression via the miR-489/DIAPH1 axis. Biochemical and biophysical research communications 18 32248974
2022 MiR-34a-5p promotes autophagy and apoptosis of ovarian granulosa cells via the Hippo-YAP signaling pathway by targeting LEF1 in chicken. Poultry science 17 36529101
2019 The Wnt/β-Catenin/LEF1 Pathway Promotes Cell Proliferation at Least in Part Through Direct Upregulation of miR-17-92 Cluster. Frontiers in genetics 17 31191623
2018 β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma). Virchows Archiv : an international journal of pathology 17 29736797
2007 LEF-1 is a decisive transcription factor in neutrophil granulopoiesis. Annals of the New York Academy of Sciences 17 17360796
2021 Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas. Science advances 16 34788095
2020 Long non-coding RNA LEF1-AS1 is involved in the progression of retinoblastoma through regulating the Wnt/β-catenin pathway. Clinical and experimental pharmacology & physiology 16 31990064
2020 LEF1 haploinsufficiency causes ectodermal dysplasia. Clinical genetics 16 32022899
2022 Lef1 and Dlx3 May Facilitate the Maturation of Secondary Hair Follicles in the Skin of Gansu Alpine Merino. Genes 15 35893063
2022 The expression changes of transcription factors including ANKZF1, LEF1, CASZ1, and ATOH1 as a predictor of survival rate in colorectal cancer: a large-scale analysis. Cancer cell international 15 36344988
2022 miR-34a Regulates Lipid Droplet Deposition in 3T3-L1 and C2C12 Cells by Targeting LEF1. Cells 15 36611960
2019 β-catenin/LEF1/IGF-IIR Signaling Axis Galvanizes the Angiotensin-II- induced Cardiac Hypertrophy. International journal of molecular sciences 15 31480672
2023 YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells. MedComm 14 37197086
2019 Expression of LEF1 and TCF1 (TCF7) proteins associates with clinical progression of nasopharyngeal carcinoma. Journal of clinical pathology 14 30918012
2017 LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma. Oncotarget 14 27965462
2016 Expression of LEF1 in mantle cell lymphoma. Annals of diagnostic pathology 14 28038713
2023 LEF1 isoforms regulate cellular senescence and aging. Aging cell 13 37961030

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