Affinage

KRT10

Keratin, type I cytoskeletal 10 · UniProt P13645

Length
584 aa
Mass
58.8 kDa
Annotated
2026-04-28
100 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KRT10 (Keratin 10) is a type I intermediate filament protein of the suprabasal epidermis that functions both as a structural scaffold component and as a signaling modulator controlling keratinocyte proliferation and differentiation. K10 forms obligate heterodimers with type II keratins K1 and K2 to build intermediate filaments required for desmosome integrity, nuclear envelope maintenance, and cornified envelope assembly via transglutaminase-mediated covalent cross-linking (PMID:22375063, PMID:24751727, PMID:7528240). Through its non-helical N-terminal domain, K10 physically sequesters Akt/PKB and PKCζ within the cytoskeleton, inhibiting their activation and thereby suppressing pRb phosphorylation, cyclin D1 expression, NF-κB signaling, and cell cycle progression both in vitro and in vivo (PMID:10082575, PMID:11585925, PMID:12566451). Dominant frameshift mutations in KRT10 generate arginine-rich C-terminal peptides that redirect the protein to the nucleolus, disrupting the filament network and causing ichthyosis with confetti (PMID:20798280, PMID:32113649).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1992 High

    Establishing that tonofilament aggregation in epidermolytic hyperkeratosis is K1/K10-selective resolved which keratins are pathologically relevant in this disorder and linked K10 to its suprabasal structural role.

    Evidence Immunoelectron microscopy and immunocytochemistry on patient epidermis

    PMID:1376754

    Open questions at the time
    • No mutations identified at this stage
    • Mechanism of aggregation unknown
  2. 1994 High

    Reconstitution of patient K10 mutations in the 1A and 2B helix boundary domains demonstrated that specific rod domain positions govern filament disruption severity, establishing a structure–function map for K10 pathogenic variants and showing that K10 requires co-expression with partner keratins and a pre-existing cytoskeleton for normal filament integration.

    Evidence Site-directed mutagenesis and gene transfection in cultured keratinocytes; time-lapse microscopy in multiple cell lines; transglutaminase substrate labeling and immunoelectron microscopy

    PMID:7512983 PMID:7526994 PMID:7528240

    Open questions at the time
    • Precise stoichiometry of K1–K10 versus K2–K10 heterodimers not resolved
    • No structural model at atomic resolution
  3. 1999 High

    The discovery that K10 inhibits cell proliferation via the Rb pathway — specifically by reducing pRb phosphorylation through its non-helical terminal domains — established an unexpected signaling function for this intermediate filament protein beyond cytoskeletal scaffolding.

    Evidence Ectopic expression in cell lines, cotransfection with viral oncoproteins/cyclins/CDKs, epistasis in Rb-deficient cells, domain deletion mutagenesis

    PMID:10082575

    Open questions at the time
    • Direct binding partner mediating Rb pathway inhibition not yet identified
    • In vivo validation not yet performed
  4. 2001 High

    Identification of Akt/PKB and PKCζ as direct physical interactors of K10's N-terminal domain, sequestered within the cytoskeleton, provided the mechanistic link between K10 and pRb hypophosphorylation.

    Evidence Reciprocal co-immunoprecipitation, subcellular fractionation, kinase activity assays, K10 deletion mutants

    PMID:11585925

    Open questions at the time
    • Structural basis of Akt–K10 interaction unknown
    • Whether other type I keratins share this sequestration function not tested
  5. 2002 High

    Transgenic mice expressing K10 in basal keratinocytes confirmed the in vivo relevance of K10-mediated Akt/PKCζ inhibition, showing epidermal hypoplasia and tumor suppression, thereby validating the kinase-sequestration model.

    Evidence K14 promoter-driven K10 transgenic mice, BrdU proliferation assays, kinase activity measurements

    PMID:11889133

    Open questions at the time
    • Tumor suppression only tested in chemical carcinogenesis model
    • Endogenous K10 loss-of-function not yet examined
  6. 2003 High

    Extending the Akt-inhibition model, K10-mediated suppression of NF-κB via decreased IKKβ/IKKγ expression linked K10 to inflammatory signaling, demonstrating broader pathway consequences of kinase sequestration.

    Evidence Transgenic mouse epidermis, NF-κB reporter assays, IKK Western blots, cytokine measurements

    PMID:12566451

    Open questions at the time
    • Whether K10 loss in vivo hyperactivates NF-κB not directly tested
    • Contribution of JNK activation to phenotype unclear
  7. 2005 Medium

    Ectopic K10 in thymic epithelium altered thymocyte differentiation via Akt-Notch pathway modulation, demonstrating non-cell-autonomous signaling effects and extending K10's role beyond epidermal keratinocytes.

    Evidence K5 promoter-driven K10 transgenic mice, flow cytometry, Notch pathway analysis

    PMID:15786499

    Open questions at the time
    • Mechanism linking Akt inhibition to Notch changes not defined
    • Physiological relevance outside ectopic expression context uncertain
  8. 2010 High

    Discovery that ichthyosis with confetti arises from KRT10 frameshift mutations generating arginine-rich C-terminal peptides that redirect K10 to the nucleolus — with reversion via mitotic recombination — established a novel disease mechanism connecting keratin mislocalization to pathology.

    Evidence Genetic mapping, sequencing, immunofluorescence of mutant K10 in patient tissue, LOH analysis across multiple patients

    PMID:20798280

    Open questions at the time
    • What nucleolar function is disrupted by mutant K10 not defined
    • No rescue experiment in patient cells
  9. 2012 High

    K1/K10 double-knockout mice revealed that these IFs are required for desmosome stability and nuclear envelope integrity in the upper epidermis, establishing structural roles beyond simple cytoskeletal scaffolding.

    Evidence Krt1/Krt10 double-KO mice, electron microscopy, desmosomal/nuclear envelope protein quantification

    PMID:22375063

    Open questions at the time
    • Whether K10 alone versus K1 alone is responsible for nuclear envelope effects not resolved
    • Mechanism of nuclear lamina regulation unclear
  10. 2014 High

    Genetic epistasis between Krt2 and Krt10 knockouts demonstrated that K2 is the obligate type II partner for K10 at specific body sites, and that imbalanced expression drives pathological keratin aggregation.

    Evidence Krt2 single-KO and Krt2/Krt10 double-KO mice, immunofluorescence, electron microscopy

    PMID:24751727

    Open questions at the time
    • Relative contributions of K1–K10 versus K2–K10 heterodimers at different body sites not fully mapped
  11. 2020 Medium

    Identification of Tp63 as a direct transcriptional activator of KRT10 via promoter binding connected K10 expression to the master keratinocyte differentiation program.

    Evidence ChIP assay for Tp63 at KRT10 promoter, Tp63 siRNA knockdown in keratinocytes

    PMID:32168425

    Open questions at the time
    • Other transcription factors cooperating with Tp63 at the KRT10 locus not identified
    • Single lab study
  12. 2023 Medium

    Discovery that KRT10 influences endosomal pH regulation and is required for avian influenza virus uncoating revealed an unexpected role for K10 in endosomal trafficking beyond its established epidermal functions.

    Evidence GST-pulldown with viral NS2, siRNA KD with endosomal pH measurement and viral titer assays

    PMID:37406407

    Open questions at the time
    • Mechanism by which K10 regulates endosomal pH unknown
    • Whether this is relevant to endogenous endosomal biology in keratinocytes not established
    • No independent replication

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis of Akt/PKCζ sequestration by K10's N-terminal domain, the mechanism by which K1/K10 filaments maintain nuclear envelope integrity, and whether K10's kinase-sequestration function is shared by other type I keratins remain unresolved.
  • No atomic-resolution structure of K10 or K10–Akt complex
  • Endogenous K10-only knockout phenotype in signaling not fully characterized
  • Nucleolar impact of arginine-rich mutant K10 not mechanistically defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 5 GO:0098772 molecular function regulator activity 4 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005856 cytoskeleton 4 GO:0005730 nucleolus 2 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-1640170 Cell Cycle 3 R-HSA-1643685 Disease 3 R-HSA-1266738 Developmental Biology 2
Partners
AKT1KRT1KRT2PRKCZPTENTP63
Complex memberships
K1/K10 intermediate filamentK2/K10 intermediate filamentcornified envelope

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 KRT10 (K10) inhibits cell proliferation by acting on the retinoblastoma (Rb) pathway: K10 expression reduces pRb phosphorylation and cyclin D1 expression, and this inhibitory function maps to the non-alpha-helical terminal domains of K10. K16 coexpression rescues K10-induced arrest. The inhibitory function is absent in Rb-deficient cells but restored by pRb or p107 cotransfection. Ectopic expression, cotransfection with viral oncoproteins/cyclins/CDKs, Rb-deficient cell rescue, deletion mutagenesis, Western blotting Molecular and cellular biology High 10082575
2001 K10 physically interacts with Akt (PKB) and atypical PKCζ, sequestering these kinases within the cytoskeleton and inhibiting their intracellular translocation and activation, thereby impeding pRb phosphorylation and reducing cyclin D1 and cyclin E expression. The interaction involves the non-alpha-helical N-terminal domain of K10. Co-immunoprecipitation, physical interaction assays, subcellular fractionation, kinase activity assays, K10 deletion mutants Molecular and cellular biology High 11585925
2002 In vivo ectopic expression of K10 in basal epidermal keratinocytes of transgenic mice causes hypoplasia and hyperkeratosis due to decreased keratinocyte proliferation, associated with inhibition of Akt and PKCζ activities, confirming K10's role in controlling epithelial proliferation in vivo and suppressing skin tumorigenesis. Transgenic mouse model, histology, proliferation assays (BrdU), kinase activity assays The Journal of biological chemistry High 11889133
2003 K10 expression in basal keratinocytes of transgenic mice inhibits Akt activity, leading to impaired NF-κB activation through decreased IKKβ and IKKγ expression, with concomitant increased TNFα production and JNK activation, demonstrating K10 regulates NF-κB signaling via the Akt pathway in vivo. Transgenic mouse model, Western blotting, reporter assays for NF-κB, kinase activity assays, cytokine measurements The Journal of biological chemistry High 12566451
2010 Frameshift mutations in KRT10 that cause ichthyosis with confetti produce an arginine-rich C-terminal peptide that redirects keratin 10 from the cytokeratin filament network to the nucleolus. Reversion occurs by mitotic recombination causing loss of heterozygosity, demonstrating the mutant K10 mislocalization is the pathogenic mechanism. Genetic mapping, sequencing, immunofluorescence localization of mutant K10 protein, loss-of-heterozygosity analysis Science (New York, N.Y.) High 20798280
1992 The tonofilament aggregation characteristic of epidermolytic hyperkeratosis is selective for K1 and K10, as demonstrated by immunoelectron microscopy showing aggregated tonofilaments in suprabasal epidermis predominantly express K1 and K10, following their known tissue distribution, and absent from epithelia lacking K1/K10. Immunoelectron microscopy, immunocytochemistry, ultrastructural analysis The Journal of investigative dermatology High 1376754
1994 Mutations in the helix initiation peptide (1A domain) or helix termination peptide (2B domain) of K10 functionally disrupt keratin filament network formation, as demonstrated by genetic engineering and gene transfection showing that each patient mutation reproduces the keratin filament aberrations seen in cultured patient keratinocytes, with more central rod domain mutations causing more severe disruption. Site-directed mutagenesis, gene transfection, keratin filament network assessment in cultured keratinocytes The Journal of clinical investigation High 7512983
1994 Mouse keratin 10 is a substrate for transglutaminase and is tightly bound (covalently cross-linked) to the cornified envelope in the stratum corneum, as identified by dansylcadaverine labeling, cDNA library immunoscreening, immunoelectron microscopy with anti-K10 antibody, and reactivity of proteolytic cornified envelope fragments with anti-K10 antibody. Transglutaminase substrate labeling (dansylcadaverine), cDNA library screening, immunoelectron microscopy, proteolytic fractionation and immunoblotting The Journal of investigative dermatology High 7528240
1994 K10 and K1 require a pre-existing keratin cytoskeleton for normal filament assembly; K10 alone forms stable non-filamentous aggregates in transfected cells and only evolves into intermediate filaments together with endogenous keratins through a dynamic process involving substantial cytoskeletal rearrangement. K10 integrates into IFs via an intermediate aggregate stage rather than directly. Transfection of K1/K10 into epithelial and non-epithelial cell lines, time-lapse microscopy, immunofluorescence kinetic experiments Experimental cell research Medium 7526994
2012 Deletion of both K1 and K10 in mice results in complete absence of IFs in suprabasal epidermis, with altered desmosomal protein expression (desmoplakin, desmocollin 1, desmoglein 1) and smaller suprabasal desmosomes, revealing a role for K1/K10 IFs in desmosome dynamics. Additionally, K1/K10 deletion causes premature nuclear loss and reduced emerin, lamin A/C, and Sun1 levels, demonstrating a function for these IFs in maintaining nuclear integrity in the upper epidermis. Krt1/Krt10 double knockout mouse model, electron microscopy, immunofluorescence, Western blotting, dye exclusion barrier assay Journal of cell science High 22375063
2014 Loss of the type II keratin K2, which heterodimerizes with K10, causes aberrant aggregation of K10 in suprabasal keratinocytes. Deletion of both K2 and K10 suppresses aggregate formation, while deletion of K10 alone causes K2 clumping, demonstrating that K2 is the necessary and sufficient binding partner of K10 at distinct body sites and that unbalanced expression causes aggregate formation. Krt2 knockout and Krt2/Krt10 double knockout mouse models, immunofluorescence, electron microscopy, Western blotting The Journal of investigative dermatology High 24751727
2020 Tp63 directly binds to the KRT10 promoter region to activate its transcription in basal keratinocytes, as demonstrated by chromatin immunoprecipitation; Tp63 silencing reverses ozone-induced upregulation of KRT10, establishing Tp63 as a transcriptional activator of KRT10. ChIP assay, siRNA knockdown of Tp63, qRT-PCR, Western blotting, promoter binding assay Journal of cellular and molecular medicine Medium 32168425
2020 KRT10 frameshift mutations in ichthyosis with confetti result in K10 C-terminal arginine-rich tails that cause nucleolar mislocalization of K10, and the degree of mislocalization correlates with the number of arginine residues in the mutant tail. Sanger sequencing, overexpression of mutant KRT10-EGFP fusion in HaCaT cells, immunofluorescence in patient skin biopsies Journal of dermatological science Medium 32113649
2014 KRT10 is a downstream effector of PTEN and directly interacts with PTEN, as shown by co-immunoprecipitation in ovarian cancer cells; cisplatin induces KRT10 upregulation in PTEN-expressing cells, and KRT10 overexpression enhances cisplatin sensitivity while KRT10 siRNA blocks it. Co-immunoprecipitation, siRNA knockdown, overexpression, MTT proliferation assay, apoptosis assay Biochemical and biophysical research communications Low 24434152
2023 KRT10 (Keratin 10) interacts with the avian influenza virus NS2 protein (identified by GST-pulldown and mass spectrometry) and co-localizes with viral NP protein in early infection. KRT10 knockdown traps AIV in late endosomes/lysosomes by increasing endosomal/lysosomal pH, preventing viral fusion and uncoating, demonstrating a role for KRT10 in endosomal trafficking and viral genome release. GST-pulldown, mass spectrometry, siRNA knockdown, immunofluorescence co-localization, endosomal pH measurement, viral titer assay Veterinary microbiology Medium 37406407
2005 Ectopic K10 expression in thymic epithelial cells reduces Akt activity in TEC (but not thymocytes), alters Notch family member expression in both TEC and T cells, and produces altered thymocyte differentiation and premature thymic involution, demonstrating K10's non-cell-autonomous signaling effects via Akt-Notch pathway modulation. Transgenic mouse model (K5 promoter-driven K10), flow cytometry, Western blotting, kinase activity assays, Notch pathway analysis Journal of cellular biochemistry Medium 15786499

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1995 Cell density and culture factors regulate keratinocyte commitment to differentiation and expression of suprabasal K1/K10 keratins. The Journal of investigative dermatology 223 7530273
1995 Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas. Journal of virology 186 7983737
2010 Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10. Science (New York, N.Y.) 149 20798280
1999 Modulation of cell proliferation by cytokeratins K10 and K16. Molecular and cellular biology 144 10082575
1992 Selective involvement of keratins K1 and K10 in the cytoskeletal abnormality of epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma). The Journal of investigative dermatology 122 1376754
1978 fs(1)K10, a germline-dependent female sterile mutation causing abnormal chorion morphology inDrosophila melanogaster. Wilhelm Roux's archives of developmental biology 116 28305014
2001 Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest. Molecular and cellular biology 104 11585925
2002 The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis. The Journal of biological chemistry 91 11889133
1995 A small predicted stem-loop structure mediates oocyte localization of Drosophila K10 mRNA. Development (Cambridge, England) 87 8582290
1994 Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity. The Journal of clinical investigation 85 7512983
1993 Human endogenous retroviral element K10 (HERV-K10) encodes a full-length gag homologous 73-kDa protein and a functional protease. AIDS research and human retroviruses 83 8512750
2012 Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity. Journal of cell science 70 22375063
2009 Directed evolution of a quorum-quenching lactonase from Mycobacterium avium subsp. paratuberculosis K-10 in the amidohydrolase superfamily. Biochemistry 57 19374350
2001 Novel tetracycline resistance gene, tet(32), in the Clostridium-related human colonic anaerobe K10 and its transmission in vitro to the rumen anaerobe Butyrivibrio fibrisolvens. Antimicrobial agents and chemotherapy 56 11600392
1996 Human endogenous retrovirus K10 encodes a functional integrase. Journal of virology 50 8627815
2016 Expanding the Clinical and Genetic Spectrum of KRT1, KRT2 and KRT10 Mutations in Keratinopathic Ichthyosis. Acta dermato-venereologica 48 26581228
2010 Localization of proteins in the cell wall of Mycobacterium avium subsp. paratuberculosis K10 by proteomic analysis. Proteome science 48 20377898
1998 Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease? Biochemistry 48 9860826
1979 Interaction of bacteriophage K10 with its receptor, the lamB protein of Escherichia coli. Journal of bacteriology 48 387746
1997 Expression of keratins (K10 and K17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts. The American Journal of dermatopathology 47 9185910
1987 Oocyte-specific transcription of fs(1)K10: a Drosophila gene affecting dorsal-ventral developmental polarity. The EMBO journal 46 16453754
1996 Taxonomic identification of Streptomyces exfoliatus K10 and characterization of its poly(3-hydroxybutyrate) depolymerase gene. FEMS microbiology letters 45 8810505
1994 Binding of keratin intermediate filaments (K10) to the cornified envelope in mouse epidermis: implications for barrier function. The Journal of investigative dermatology 45 7528240
1985 A 43 kilobase cosmid P transposon rescues the fs(1)K10 morphogenetic locus and three adjacent Drosophila developmental mutants. Cell 44 2985265
2006 Purification and characterization of a nitrilase from Aspergillus niger K10. Applied microbiology and biotechnology 43 17061133
1999 Genetic organization of the Escherichia coli K10 capsule gene cluster: identification and characterization of two conserved regions in group III capsule gene clusters encoding polysaccharide transport functions. Journal of bacteriology 40 10094710
1988 Role of the oocyte nucleus in determination of the dorsoventral polarity of Drosophila as revealed by molecular analysis of the K10 gene. Genes & development 40 12553295
2014 Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation. The Journal of investigative dermatology 36 24751727
2006 Proteome and differential expression analysis of membrane and cytosolic proteins from Mycobacterium avium subsp. paratuberculosis strains K-10 and 187. Journal of bacteriology 35 17142399
1974 Genetic mapping of the antigenic determinants of two polysaccharide K antigens, K10 and K54, in Escherichia coli. Journal of bacteriology 35 4138850
1975 L-phenylalanine:tRNA ligase of Escherichia coli K10. A rapid kinetic investigation of the catalytic reaction. Biochemistry 34 1101957
2023 Isolation and characterization of novel bacteriophage vB_KpP_HS106 for Klebsiella pneumonia K2 and applications in foods. Frontiers in microbiology 33 37655345
2019 Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes. The Journal of investigative dermatology 32 30998984
2007 Human K10 epithelial keratin is the most abundant protein in airborne dust of both occupied and unoccupied school rooms. Journal of environmental monitoring : JEM 32 18175017
2006 Expression of Kaposi's sarcoma-associated herpesvirus-encoded K10/10.1 protein in tissues and its interaction with poly(A)-binding protein. Virology 32 16716377
1995 Cloning and analysis of gene clusters for production of the Escherichia coli K10 and K54 antigens: identification of a new group of serA-linked capsule gene clusters. Journal of bacteriology 32 7608072
2014 PTEN overexpression improves cisplatin-resistance of human ovarian cancer cells through upregulating KRT10 expression. Biochemical and biophysical research communications 31 24434152
1999 High prevalence of antibodies against HERV-K10 in patients with testicular cancer but not with AIDS. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 31 10207631
1995 The role of fs(1)K10 in the localization of the mRNA of the TGF alpha homolog gurken within the Drosophila oocyte. Mechanisms of development 31 7547466
2003 Splice site and deletion mutations in keratin (KRT1 and KRT10) genes: unusual phenotypic alterations in Scandinavian patients with epidermolytic hyperkeratosis. The Journal of investigative dermatology 29 14708600
2021 A Broad-Specificity Chitinase from Penicillium oxalicum k10 Exhibits Antifungal Activity and Biodegradation Properties of Chitin. Marine drugs 28 34201595
1994 Assembly dynamics of epidermal keratins K1 and K10 in transfected cells. Experimental cell research 26 7526994
2010 Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling. Journal of virology 25 20861242
2014 Mangromicins, six new anti-oxidative agents isolated from a culture broth of the actinomycete, Lechevalieria aerocolonigenes K10-0216. The Journal of antibiotics 24 24690908
2005 The potential role of human endogenous retrovirus K10 in the pathogenesis of rheumatoid arthritis: a preliminary study. Annals of the rheumatic diseases 23 16192292
2015 Keratins K2 and K10 are essential for the epidermal integrity of plantar skin. Journal of dermatological science 22 26603179
2015 The phenotypic and genotypic spectra of ichthyosis with confetti plus novel genetic variation in the 3' end of KRT10: from disease to a syndrome. JAMA dermatology 21 25210931
2015 Novel extracellular medium-chain-length polyhydroxyalkanoate depolymerase from Streptomyces exfoliatus K10 DSMZ 41693: a promising biocatalyst for the efficient degradation of natural and functionalized mcl-PHAs. Applied microbiology and biotechnology 21 26156240
1996 Comparative analysis of the kinetics and dynamics of K10, bicoid, and oskar mRNA localization in the Drosophila oocyte. Developmental genetics 21 8952066
1984 Phenylalanyl-tRNA synthetase of Escherichia coli K10. Effects of zinc(II) on partial reactions of diadenosine 5',5"'-P1,P4-tetraphosphate synthesis, conformation, and protein aggregation. Biochemistry 20 6365159
1982 Catalytic mechanism of phenylalanyl-tRNA synthetase of Escherichia coli K10. Conformational change and tRNAPhe phenylalanylation are concerted. Biochemistry 19 7046787
2015 KPP: KEGG Pathway Painter. BMC systems biology 18 25879163
2011 Description of the natural course and clinical manifestations of ichthyosis with confetti caused by a novel KRT10 mutation. The British journal of dermatology 18 21929535
2010 Lethal autosomal recessive epidermolytic ichthyosis due to a novel donor splice-site mutation in KRT10. The British journal of dermatology 18 20302579
2003 Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis. The Journal of biological chemistry 17 12566451
1991 Microheterogeneity of rat submaxillary gland kallikrein k10, a member of the kallikrein family. European journal of biochemistry 17 2026164
2020 Ozone therapy promotes the differentiation of basal keratinocytes via increasing Tp63-mediated transcription of KRT10 to improve psoriasis. Journal of cellular and molecular medicine 16 32168425
2011 Heterologous expression, purification and characterization of nitrilase from Aspergillus niger K10. BMC biotechnology 16 21210990
2009 Continuous hydrolysis of 4-cyanopyridine by nitrilases from Fusarium solani O1 and Aspergillus niger K10. Applied microbiology and biotechnology 16 19554325
1990 Differential expression of the epidermal K1 and K10 keratin genes during mouse embryo development. Biochemistry and cell biology = Biochimie et biologie cellulaire 16 1693084
2001 Inhibition of human endogenous retrovirus-K10 protease in cell-free and cell-based assays. The Journal of biological chemistry 15 11278433
2020 Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes. Scientific reports 14 32179842
2013 Increased seroreactivity to HERV-K10 peptides in patients with HTLV myelopathy. Virology journal 14 24365054
2002 Severe abnormalities in the oral mucosa induced by suprabasal expression of epidermal keratin K10 in transgenic mice. The Journal of biological chemistry 14 12119299
1996 Identification of K1/K10 and K5/K14 keratin pairs in human melanoma cell lines. Journal of dermatological science 14 9023704
1975 Regulation of Escherichia coli K10 aminoendopeptidase synthesis. Effects of mutations involved in the regulation of alkaline phosphatase. European journal of biochemistry 14 1107040
2014 Strategy for automated NMR resonance assignment of RNA: application to 48-nucleotide K10. Journal of biomolecular NMR 12 24899400
1994 Expression of keratins K6 and K16 in regenerating mouse epidermis is less restricted by cell replication than the expression of K1 and K10. Epithelial cell biology 12 7534576
1993 A regulatory function for K10 in the establishment of dorsoventral polarity in the Drosophila egg and embryo. Mechanisms of development 12 8518190
2018 Analysis of KRT1, KRT10, KRT19, TP53 and MMP9 expression in pediatric and adult cholesteatoma. PloS one 11 30021014
2013 Retinoids reduce formation of keratin aggregates in heat-stressed immortalized keratinocytes from an epidermolytic ichthyosis patient with a KRT10 mutation*. Acta dermato-venereologica 10 22504942
2005 Altered T cell differentiation and Notch signaling induced by the ectopic expression of keratin K10 in the epithelial cells of the thymus. Journal of cellular biochemistry 10 15786499
2021 Case Report: Uncommon Association of ITGB4 and KRT10 Gene Mutation in a Case of Epidermolysis Bullosa With Pyloric Atresia and Aplasia Cutis Congenita. Frontiers in genetics 9 34306001
2015 Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo. Genetics and molecular research : GMR 9 26125866
2014 Assessing the ability of the 2D Fisher-KPP equation to model cell-sheet wound closure. Mathematical biosciences 9 24657222
2010 Montmorillonite K-10 catalyzed cyclization of N-ethoxycarbonyl-N'-arylguanidines: access to pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole derivatives. Bioorganic & medicinal chemistry letters 9 20570510
2009 Epidermolytic hyperkeratosis with palmoplantar keratoderma in a patient with KRT10 mutation. European journal of dermatology : EJD 9 19443303
1981 Detection of ligand-induced conformational changes in phenylalanyl-tRNA synthetase of Escherichia coli K10 by laser light scattering. Biochemistry 9 7011376
1976 L-Phenylalanine: tRNA ligase of Escherichia coli K10. The effect of O replaced by S substitution on substrate and ligand binding properties of ATP. European journal of biochemistry 9 786618
2023 Effect of montmorillonite K10 clay on RNA structure and function. Biophysical journal 7 37924206
1980 Kinetics of anticooperative binding of phenylalanyl-tRNAPhe and tRNAPhe to phenylalanyl-tRNA synthetase of Escherichia coli K10. Biochemistry 7 6992864
2020 Ichthyosis with confetti caused by new and recurrent mutations in KRT10 associated with varying degrees of keratin 10 mis-localization. Journal of dermatological science 6 32113649
2017 Coexistence of mutations in keratin 10 (KRT10) and the mitochondrial genome in a patient with ichthyosis with confetti and Leber's hereditary optic neuropathy. American journal of medical genetics. Part A 6 28944608
2009 Bullous congenital ichthyosiform erythroderma: a sporadic case produced by a new KRT10 gene mutation. Pediatric dermatology 6 19689541
1997 A keratin K10 gene mutation in a Japanese patient with epidermolytic hyperkeratosis. The Japanese journal of human genetics 6 9184002
1994 Solution structure of the DNA binding octapeptide repeat of the K10 gene product. Protein engineering 6 8029203
2023 KRT10 plays an important role in the release of viral genome from endosomes during H9N2 subtype AIV replication in HeLa cells. Veterinary microbiology 5 37406407
2022 Cytokeratin 10 (CK10) expression in cancer: A tissue microarray study on 11,021 tumors. Annals of diagnostic pathology 5 36029589
2022 Utility of CK8, CK10, CK13, and CK17 in Differential Diagnostics of Benign Lesions, Laryngeal Dysplasia, and Laryngeal Squamous Cell Carcinoma. Diagnostics (Basel, Switzerland) 5 36553210
2021 Post Zygotic, Somatic, Deletion in KERATIN 1 V1 Domain Generates Structural Alteration of the K1/K10 Dimer, Producing a Monolateral Palmar Epidermolytic Nevus. International journal of molecular sciences 5 34199056
2014 Evaluation of specific marker CK13 and CK10/13 combined with APM staining for the diagnosis of amniotic fluid embolism and aspiration. Forensic science international 5 24705378
2011 Montmorillonite K-10 mediated green synthesis of cyano pyridines: Their evaluation as potential inhibitors of PDE4. European journal of medicinal chemistry 5 22217868
2009 Keratin 10 (K10) is expressed suprabasally throughout the limbus of embryonic and neonatal rat corneas, with interrupted expression in the adult limbus. Experimental eye research 5 19344714
2023 The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 4 37295249
2023 Characterization and biocontrol efficacy of lytic phage (KPP-1) that infects multidrug resistant Klebsiella variicola. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 4 37368195
2021 Effect of the deletion of lprG and p55 genes in the K10 strain of Mycobacterium avium subspecies paratuberculosis. Research in veterinary science 4 34087563
2021 Selective Targeting of the Novel CK-10 Nanoparticles to the MDA-MB-231 Breast Cancer Cells. Journal of pharmaceutical sciences 4 34929154
2014 Clinicopathological features and expression of four keratins (K10, K14, K17 and K19) in six cases of eruptive vellus hair cysts. Clinical and experimental dermatology 4 24773427
2000 Recurrent R156H mutation of KRT10 in a Japanese family with bullous congenital ichthyosiform erythroderma. Journal of the European Academy of Dermatology and Venereology : JEADV 4 11204523
2020 Mutations in KRT10 in epidermolytic acanthoma. Journal of cutaneous pathology 3 32045015