Affinage

KRT10

Keratin, type I cytoskeletal 10 · UniProt P13645

Length
584 aa
Mass
58.8 kDa
Annotated
2026-06-10
100 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KRT10 encodes keratin 10, a type I intermediate filament protein that builds the suprabasal keratin cytoskeleton of the epidermis by obligate heterodimerization with type II partner keratins—K1 in most epidermis and K2 at distinct body sites (ear, sole, tail), where imbalanced K2/K10 stoichiometry drives protein aggregation (PMID:24751727). K10 cannot assemble a filament network alone and integrates into a pre-existing keratin cytoskeleton through dynamic rearrangement of endogenous filaments (PMID:7526994). Beyond its structural role, K10 functions as a negative regulator of keratinocyte proliferation: ectopic K10 inhibits proliferation through the Rb pathway, lowering pRb phosphorylation and cyclin D1 expression in an Rb-dependent manner, an activity mapped to its non-helical terminal domains (PMID:10082575). Mechanistically, the K10 N-terminal domain physically binds and sequesters Akt and atypical PKCζ in the cytoskeleton, blocking their activation and thereby reducing cyclin D1/E expression and cell-cycle progression (PMID:11585925); transgenic expression of K10 in basal cells confirms in vivo inhibition of Akt and PKCζ with reduced proliferation and tumor resistance (PMID:11889133), and the resulting Akt suppression in turn impairs NF-κB activation via decreased IKKβ/γ (PMID:12566451). Loss of both K1 and K10 abolishes suprabasal filaments and reveals additional roles in desmosome dynamics and nuclear envelope integrity (PMID:22375063), while K10 is also a covalently cross-linked transglutaminase substrate of the cornified envelope (PMID:7528240). KRT10 is a Mendelian disease gene: dominant mutations at the conserved ends of the rod domain disrupt filament assembly and cause epidermolytic hyperkeratosis (PMID:7512983), whereas C-terminal frameshift mutations generate an arginine-rich tail that mislocalizes K10 to the nucleolus in ichthyosis with confetti (PMID:20798280). KRT10 transcription is directly activated by Tp63 in basal keratinocytes (PMID:32168425).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1992 Medium

    Localized the cytoskeletal defect of epidermolytic hyperkeratosis specifically to K1/K10-containing suprabasal filaments rather than other keratins, implicating KRT10 in the disease.

    Evidence Immunoelectron microscopy with keratin-specific antibodies on EHK patient skin and cultured keratinocytes

    PMID:1376754

    Open questions at the time
    • Did not identify the causative mutations
    • Did not establish how filament aggregation arises mechanistically
  2. 1994 High

    Established the dominant-negative disease mechanism by showing engineered rod-domain mutations disrupt filament assembly, with severity tracking mutation position near the helix termini.

    Evidence Transfection of engineered mutant KRT10 alleles into keratinocytes with filament network analysis

    PMID:7512983

    Open questions at the time
    • Did not resolve atomic-level effect on dimer/filament structure
    • Did not address non-helical domain functions
  3. 1994 Medium

    Defined K10's assembly requirements, showing it cannot form filaments alone and must integrate into a pre-existing keratin network in an epithelial context.

    Evidence Transfection of K1/K10 into fibroblasts and epithelial lines with kinetic immunofluorescence

    PMID:7526994

    Open questions at the time
    • Mechanism of dynamic integration into endogenous IFs not resolved
    • In vivo relevance not tested
  4. 1994 Medium

    Connected K10 filaments to the cornified envelope by identifying K10 as a covalently cross-linked transglutaminase substrate contributing to stratum corneum integrity.

    Evidence Dansylcadaverine labeling, immunoelectron microscopy, and biochemical fractionation of cornified envelope

    PMID:7528240

    Open questions at the time
    • Specific cross-linking residues and transglutaminase isoform not defined
    • Quantitative contribution to barrier function unaddressed
  5. 1999 High

    Revealed an unexpected non-structural function: K10 inhibits keratinocyte proliferation through the Rb pathway, mapped to its non-helical terminal domains.

    Evidence Ectopic expression in keratinocytes with cyclin/CDK/Rb rescue, Rb-deficient cells, and deletion mutants

    PMID:10082575

    Open questions at the time
    • Did not identify the direct molecular target of the terminal domains
    • Mechanism linking K10 to pRb phosphorylation unknown at this stage
  6. 2001 High

    Identified the molecular basis of K10's anti-proliferative activity—physical sequestration of Akt and PKCζ by the N-terminal domain to block their activation.

    Evidence Reciprocal co-immunoprecipitation, kinase activity assays, and deletion mutant transfections

    PMID:11585925

    Open questions at the time
    • Structural basis of kinase binding not resolved
    • Stoichiometry and regulation of sequestration unknown
  7. 2002 High

    Confirmed in vivo that K10 controls epithelial proliferation and tumor resistance via Akt/PKCζ inhibition.

    Evidence Basal-promoter K10 transgenic mice with kinase activity assays, BrdU, and tumor induction

    PMID:11889133

    Open questions at the time
    • Did not dissect relative contributions of Akt vs PKCζ
    • Downstream effectors beyond cyclins not fully mapped
  8. 2003 Medium

    Extended the K10-Akt axis to inflammatory signaling, showing K10-mediated Akt inhibition impairs NF-κB via reduced IKKβ/γ with elevated TNF-α and JNK.

    Evidence Transgenic mice with IKK Western blot, NF-κB reporter, TNF-α ELISA, and JNK assays

    PMID:12566451

    Open questions at the time
    • Single-lab transgenic model
    • Mechanism linking Akt to IKK expression not detailed
  9. 2005 Medium

    Showed K10-mediated Akt inhibition can act non-cell-autonomously, modulating Notch signaling and T cell differentiation in thymic epithelium.

    Evidence K5-promoter K10 transgenic mice with Akt assays, Notch readouts, and thymocyte flow cytometry

    PMID:15786499

    Open questions at the time
    • Physiological relevance outside the transgenic context unclear
    • Direct link between Akt and Notch ligand expression not established
  10. 2010 High

    Defined a distinct disease mechanism in which C-terminal frameshift mutations produce an arginine-rich tail that mislocalizes K10 to the nucleolus, with somatic reversion restoring normal skin.

    Evidence Whole-genome mapping of mitotic revertant clones, sequencing, and mutant protein localization

    PMID:20798280

    Open questions at the time
    • Functional consequence of nucleolar K10 not defined
    • Why arginine-rich tail targets the nucleolus mechanistically unresolved
  11. 2012 High

    Established roles for K1/K10 filaments beyond mechanical support—in desmosome dynamics and nuclear envelope integrity—while showing stratification and barrier formation are surprisingly IF-independent.

    Evidence Krt1-/-;Krt10-/- double knockout mice with EM, immunofluorescence, barrier assay, and Western blot

    PMID:22375063

    Open questions at the time
    • Molecular links between K1/K10 IFs and desmosomal/nuclear envelope proteins not defined
    • Mechanism of premature nuclear loss unresolved
  12. 2014 High

    Demonstrated by genetic epistasis that K2 is a necessary and sufficient type II partner of K10 at distinct body sites and that stoichiometric imbalance drives aggregation.

    Evidence Krt2-/- and Krt2-/-;Krt10-/- knockout mice with immunofluorescence, Western blot, histology

    PMID:24751727

    Open questions at the time
    • Biophysical basis of imbalance-induced aggregation not defined
    • Site-specific regulation of K1 vs K2 pairing unaddressed
  13. 2014 Medium

    Reported a context-specific interaction with PTEN linking KRT10 to cisplatin-induced apoptosis in ovarian cancer cells.

    Evidence Co-immunoprecipitation with PTEN plus siRNA knockdown and proliferation/apoptosis assays

    PMID:24434152

    Open questions at the time
    • Single Co-IP without reciprocal validation
    • Relevance of an epidermal keratin in ovarian cancer not independently confirmed
  14. 2019 Medium

    Provided proof-of-concept that allele-specific disruption of dominant-negative KRT10 reverses the filament instability disease mechanism.

    Evidence TALEN editing of patient-derived keratinocytes with immunofluorescence and xenograft ultrastructure

    PMID:30998984

    Open questions at the time
    • Single-lab ex vivo demonstration
    • Long-term in vivo efficacy and off-target risks not fully resolved
  15. 2020 Medium

    Identified Tp63 as a direct transcriptional activator of KRT10 driving keratinocyte differentiation.

    Evidence ChIP of Tp63 on the KRT10 promoter with siRNA knockdown, qRT-PCR, and immunofluorescence

    PMID:32168425

    Open questions at the time
    • Single-lab finding
    • Additional transcriptional regulators of KRT10 not mapped
  16. 2023 Medium

    Reported a non-epidermal role in which KRT10 facilitates release of influenza viral RNPs from late endosomes via interaction with NS2.

    Evidence GST-pulldown/mass spectrometry with NS2, siRNA knockdown, colocalization, and endosomal pH assays

    PMID:37406407

    Open questions at the time
    • Single-lab finding
    • Mechanism by which KRT10 affects endosomal pH/fusion not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the structural and signaling functions of K10 are integrated—and the functional significance of nucleolar/non-epidermal localizations—remains unresolved.
  • No structural model of the K10 N-terminal domain bound to Akt/PKCζ
  • Functional consequence of nucleolar mislocalization undefined
  • Mechanistic links between K1/K10 filaments and desmosome/nuclear envelope proteins unmapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0098772 molecular function regulator activity 3 GO:0008092 cytoskeletal protein binding 1 GO:0140096 catalytic activity, acting on a protein 1
Localization
GO:0005856 cytoskeleton 2 GO:0005730 nucleolus 1 GO:0005768 endosome 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1640170 Cell Cycle 3 R-HSA-1266738 Developmental Biology 2 R-HSA-1643685 Disease 2
Partners
AKT1KRT1KRT2PRKCZPTENTP63

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 Ectopic expression of K10 inhibits proliferation of human keratinocytes by acting on the retinoblastoma (Rb) pathway: K10 reduces pRb phosphorylation and cyclin D1 expression; this inhibition is rescued by cyclins, CDKs, cyclin-CDK complexes, or co-expression of pRb/p107 but not p130, and does not occur in Rb-deficient cells. The inhibitory function was mapped to the non-helical terminal domains of K10 using deletion mutants. K16 co-expression reverses K10-induced growth arrest. Ectopic expression in human keratinocytes, cotransfection with viral oncoproteins/cyclins/CDKs, Rb-deficient cell rescue experiments, K10 deletion mutant analysis, pRb phosphorylation assays Molecular and cellular biology High 10082575
2001 K10 physically interacts with Akt (PKB) and atypical PKCζ via its non-alpha-helical amino-terminal domain (NTerm), sequesters these kinases within the cytoskeleton, inhibits their intracellular translocation and activation, and thereby impedes pRb phosphorylation and reduces cyclin D1 and E expression to arrest the cell cycle. Co-immunoprecipitation of K10 with Akt/PKCζ, kinase activity assays, K10 deletion mutant transfections, cyclin/pRb Western blotting Molecular and cellular biology High 11585925
2002 In transgenic mice ectopically expressing K10 in proliferative basal epidermal cells, K10 causes hypoplastic/hyperkeratotic epidermis via dramatic decrease in keratinocyte proliferation associated with inhibition of Akt and PKCζ activities in vivo, confirming K10's in vivo role in controlling epithelial proliferation and resistance to skin tumorigenesis. Transgenic mouse model with K10 driven by basal-layer keratin promoter; Akt and PKCζ activity assays; BrdU proliferation assay; tumor induction assays The Journal of biological chemistry High 11889133
2003 K10 expression in basal epidermal cells of transgenic mice leads to impaired NF-κB activation through decreased expression of IKKβ and IKKγ, a consequence of K10-mediated Akt inhibition. This is accompanied by increased TNF-α production and JNK activation in the epidermis. Transgenic mouse model; IKKβ/γ Western blotting; NF-κB reporter assays; TNF-α ELISA; JNK activity assays The Journal of biological chemistry Medium 12566451
2010 Dominant KRT10 frameshift mutations in ichthyosis with confetti result in a C-terminal arginine-rich peptide that redirects keratin 10 protein from the cytokeratin filament network to the nucleolus. Reversion of these mutations via mitotic recombination (loss of heterozygosity on chr17q) restores normal skin. Whole-genome mapping using mitotic reversion clones; DNA sequencing of KRT10 mutations; immunofluorescence/cellular localization of mutant K10 protein Science (New York, N.Y.) High 20798280
1994 Mouse keratin 10 is tightly bound to the cornified envelope and may function as a covalently cross-linked transglutaminase substrate, providing a mechanism by which keratin filaments interact with the cornified envelope to enhance structural integrity of the stratum corneum. Dansylcadaverine labeling of transglutaminase substrates; immunoscreening of cDNA library; DNA sequencing; immunoelectron microscopy with anti-K10 antibodies; proteolytic fragmentation of purified cornified envelope + Western blot The Journal of investigative dermatology Medium 7528240
1992 In epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma), tonofilament aggregates in suprabasal epidermis selectively and predominantly express K1 and K10 rather than other keratins (K5, K14, K16), localizing the cytoskeletal abnormality specifically to K1/K10-containing filaments. Immunoelectron microscopy with keratin-specific antibodies on skin biopsies from EHK patients; electron microscopy; immunocytochemistry on cultured keratinocytes The Journal of investigative dermatology Medium 1376754
1994 Mutations at or near the conserved ends of the K10 alpha-helical rod domain (e.g., R156C in the 1A region, mutations in the 2B region) are functionally responsible for keratin filament aberrations in EHK keratinocytes; the severity of filament network disruption correlates with disease severity, with mutations closer to the helix termini causing more severe perturbations. Genetic engineering and gene transfection of mutant KRT10 alleles into keratinocytes; keratin filament network analysis by immunofluorescence The Journal of clinical investigation High 7512983
1994 K10 is unable to form a normal keratin intermediate filament network on its own in fibroblasts and requires a pre-existing keratin cytoskeleton (epithelial cell context) to integrate. K10 alone forms stable, regularly sized round aggregates that interact with endogenous keratins, actin, vimentin, and tubulin. K10 integrates into pre-existing IF networks through a dynamic process involving rearrangement of the endogenous cytoskeleton, not direct incorporation. Transient and stable transfection of K1/K10 into fibroblasts and epithelial cell lines; kinetic immunofluorescence experiments in PtK2 cells Experimental cell research Medium 7526994
2012 Deletion of both K1 and K10 in mice abolishes IFs in suprabasal epidermis (without compensatory upregulation by K5/K14), reduces desmosomal protein expression (desmoplakin, desmocollin 1, desmoglein 1) and desmosome size, causes premature nuclear loss during differentiation, and lowers levels of emerin, lamin A/C and Sun1—revealing a role for K1/K10 IFs in desmosome dynamics and nuclear integrity in the upper epidermis. Notably, epidermal stratification and water barrier formation were surprisingly independent of K1/K10 IFs. Krt1-/-; Krt10-/- double knockout mice; electron microscopy; immunofluorescence; dye exclusion barrier assay; Western blot Journal of cell science High 22375063
2014 In the absence of K2, K10 forms massive protein aggregates in suprabasal keratinocytes; conversely, absence of K10 causes K2 clumping. Deletion of both K2 and K10 suppresses aggregate formation, demonstrating that K2 is a necessary and sufficient binding partner of K10 at distinct body sites (ear, sole, tail) and that imbalanced expression of these keratins causes aggregate formation. Krt2-/- and Krt2-/-;Krt10-/- knockout mice; immunofluorescence; Western blot; histology The Journal of investigative dermatology High 24751727
2020 Tp63 directly binds the KRT10 promoter region and activates KRT10 transcription in basal keratinocytes; ozone treatment promotes K10 expression and keratinocyte differentiation via upregulation of Tp63, an effect reversed by Tp63 silencing. Chromatin immunoprecipitation (Tp63 binding to KRT10 promoter); siRNA knockdown of Tp63; qRT-PCR and Western blot for KRT10/Tp63; immunofluorescence in patient and mouse psoriatic tissues Journal of cellular and molecular medicine Medium 32168425
2014 KRT10 was identified as a protein that directly interacts with PTEN by co-immunoprecipitation in ovarian cancer cells. KRT10 expression is upregulated by cisplatin downstream of PTEN, and forced KRT10 overexpression enhances cisplatin-induced proliferation inhibition and apoptosis; KRT10 siRNA blocks this effect in PTEN-expressing cells. Co-immunoprecipitation of KRT10 with PTEN; KRT10 siRNA knockdown; MTT proliferation assay; apoptosis assay; qRT-PCR/Western blot Biochemical and biophysical research communications Medium 24434152
2023 KRT10 physically interacts with influenza virus NS2 protein (identified by GST-pulldown and mass spectrometry). KRT10 knockdown reduces viral NP mRNA and protein expression, traps AIV particles in late endosomes/lysosomes, increases endosomal/lysosomal pH, and prevents viral fusion/uncoating—indicating KRT10 facilitates release of viral RNPs from late endosomes during AIV infection. GST-pulldown with NS2; mass spectrometry; KRT10 siRNA knockdown; immunofluorescence colocalization with Lamp1/NP; endosomal pH measurement; offspring virus titer assay Veterinary microbiology Medium 37406407
2019 TALE nuclease-mediated disruption of dominant-negative mutant KRT10 alleles in patient-derived keratinocytes (ex vivo) restores keratin intermediate filament stability, as confirmed by immunofluorescence and ultrastructural analysis of murine xenograft models, demonstrating that the dominant negative disease mechanism of KRT10 mutations can be reversed by allele-specific disruption. TALEN gene editing; immunofluorescence of keratin filament networks; electron microscopy of murine xenografts; off-target analysis The Journal of investigative dermatology Medium 30998984
2005 K10 transgene expression in thymic epithelial cells (TEC) reduces Akt activity in TEC, alters Notch family member and ligand expression in both TEC and thymocytes, decreases Notch activity in TEC but increases it in thymocytes, and leads to altered T cell differentiation and premature thymus involution—demonstrating that K10-mediated Akt inhibition can non-cell-autonomously modulate cell-cell signaling via Notch. K5-promoter K10 transgenic mice; Akt kinase activity assays; Notch/ligand Western blot and RT-PCR; flow cytometry of thymocytes; histology Journal of cellular biochemistry Medium 15786499

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1995 Cell density and culture factors regulate keratinocyte commitment to differentiation and expression of suprabasal K1/K10 keratins. The Journal of investigative dermatology 223 7530273
1995 Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas. Journal of virology 186 7983737
2010 Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10. Science (New York, N.Y.) 149 20798280
1999 Modulation of cell proliferation by cytokeratins K10 and K16. Molecular and cellular biology 145 10082575
1992 Selective involvement of keratins K1 and K10 in the cytoskeletal abnormality of epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma). The Journal of investigative dermatology 122 1376754
1978 fs(1)K10, a germline-dependent female sterile mutation causing abnormal chorion morphology inDrosophila melanogaster. Wilhelm Roux's archives of developmental biology 116 28305014
2001 Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest. Molecular and cellular biology 104 11585925
2002 The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis. The Journal of biological chemistry 91 11889133
1995 A small predicted stem-loop structure mediates oocyte localization of Drosophila K10 mRNA. Development (Cambridge, England) 89 8582290
1994 Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity. The Journal of clinical investigation 85 7512983
1993 Human endogenous retroviral element K10 (HERV-K10) encodes a full-length gag homologous 73-kDa protein and a functional protease. AIDS research and human retroviruses 83 8512750
2012 Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity. Journal of cell science 71 22375063
2009 Directed evolution of a quorum-quenching lactonase from Mycobacterium avium subsp. paratuberculosis K-10 in the amidohydrolase superfamily. Biochemistry 57 19374350
2001 Novel tetracycline resistance gene, tet(32), in the Clostridium-related human colonic anaerobe K10 and its transmission in vitro to the rumen anaerobe Butyrivibrio fibrisolvens. Antimicrobial agents and chemotherapy 56 11600392
1996 Human endogenous retrovirus K10 encodes a functional integrase. Journal of virology 50 8627815
2016 Expanding the Clinical and Genetic Spectrum of KRT1, KRT2 and KRT10 Mutations in Keratinopathic Ichthyosis. Acta dermato-venereologica 48 26581228
2010 Localization of proteins in the cell wall of Mycobacterium avium subsp. paratuberculosis K10 by proteomic analysis. Proteome science 48 20377898
1998 Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease? Biochemistry 48 9860826
1979 Interaction of bacteriophage K10 with its receptor, the lamB protein of Escherichia coli. Journal of bacteriology 48 387746
1997 Expression of keratins (K10 and K17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts. The American Journal of dermatopathology 47 9185910
1987 Oocyte-specific transcription of fs(1)K10: a Drosophila gene affecting dorsal-ventral developmental polarity. The EMBO journal 46 16453754
1996 Taxonomic identification of Streptomyces exfoliatus K10 and characterization of its poly(3-hydroxybutyrate) depolymerase gene. FEMS microbiology letters 45 8810505
1994 Binding of keratin intermediate filaments (K10) to the cornified envelope in mouse epidermis: implications for barrier function. The Journal of investigative dermatology 45 7528240
1985 A 43 kilobase cosmid P transposon rescues the fs(1)K10 morphogenetic locus and three adjacent Drosophila developmental mutants. Cell 44 2985265
2006 Purification and characterization of a nitrilase from Aspergillus niger K10. Applied microbiology and biotechnology 43 17061133
1999 Genetic organization of the Escherichia coli K10 capsule gene cluster: identification and characterization of two conserved regions in group III capsule gene clusters encoding polysaccharide transport functions. Journal of bacteriology 40 10094710
1988 Role of the oocyte nucleus in determination of the dorsoventral polarity of Drosophila as revealed by molecular analysis of the K10 gene. Genes & development 40 12553295
2014 Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation. The Journal of investigative dermatology 36 24751727
2023 Isolation and characterization of novel bacteriophage vB_KpP_HS106 for Klebsiella pneumonia K2 and applications in foods. Frontiers in microbiology 35 37655345
2006 Proteome and differential expression analysis of membrane and cytosolic proteins from Mycobacterium avium subsp. paratuberculosis strains K-10 and 187. Journal of bacteriology 35 17142399
1974 Genetic mapping of the antigenic determinants of two polysaccharide K antigens, K10 and K54, in Escherichia coli. Journal of bacteriology 35 4138850
1975 L-phenylalanine:tRNA ligase of Escherichia coli K10. A rapid kinetic investigation of the catalytic reaction. Biochemistry 34 1101957
2019 Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes. The Journal of investigative dermatology 33 30998984
2007 Human K10 epithelial keratin is the most abundant protein in airborne dust of both occupied and unoccupied school rooms. Journal of environmental monitoring : JEM 33 18175017
2006 Expression of Kaposi's sarcoma-associated herpesvirus-encoded K10/10.1 protein in tissues and its interaction with poly(A)-binding protein. Virology 32 16716377
1995 Cloning and analysis of gene clusters for production of the Escherichia coli K10 and K54 antigens: identification of a new group of serA-linked capsule gene clusters. Journal of bacteriology 32 7608072
2014 PTEN overexpression improves cisplatin-resistance of human ovarian cancer cells through upregulating KRT10 expression. Biochemical and biophysical research communications 31 24434152
1999 High prevalence of antibodies against HERV-K10 in patients with testicular cancer but not with AIDS. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 31 10207631
1995 The role of fs(1)K10 in the localization of the mRNA of the TGF alpha homolog gurken within the Drosophila oocyte. Mechanisms of development 31 7547466
2021 A Broad-Specificity Chitinase from Penicillium oxalicum k10 Exhibits Antifungal Activity and Biodegradation Properties of Chitin. Marine drugs 29 34201595
2003 Splice site and deletion mutations in keratin (KRT1 and KRT10) genes: unusual phenotypic alterations in Scandinavian patients with epidermolytic hyperkeratosis. The Journal of investigative dermatology 29 14708600
1994 Assembly dynamics of epidermal keratins K1 and K10 in transfected cells. Experimental cell research 26 7526994
2014 Mangromicins, six new anti-oxidative agents isolated from a culture broth of the actinomycete, Lechevalieria aerocolonigenes K10-0216. The Journal of antibiotics 25 24690908
2010 Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling. Journal of virology 25 20861242
2005 The potential role of human endogenous retrovirus K10 in the pathogenesis of rheumatoid arthritis: a preliminary study. Annals of the rheumatic diseases 24 16192292
2015 Novel extracellular medium-chain-length polyhydroxyalkanoate depolymerase from Streptomyces exfoliatus K10 DSMZ 41693: a promising biocatalyst for the efficient degradation of natural and functionalized mcl-PHAs. Applied microbiology and biotechnology 22 26156240
2015 Keratins K2 and K10 are essential for the epidermal integrity of plantar skin. Journal of dermatological science 22 26603179
2015 The phenotypic and genotypic spectra of ichthyosis with confetti plus novel genetic variation in the 3' end of KRT10: from disease to a syndrome. JAMA dermatology 21 25210931
1996 Comparative analysis of the kinetics and dynamics of K10, bicoid, and oskar mRNA localization in the Drosophila oocyte. Developmental genetics 21 8952066
1984 Phenylalanyl-tRNA synthetase of Escherichia coli K10. Effects of zinc(II) on partial reactions of diadenosine 5',5"'-P1,P4-tetraphosphate synthesis, conformation, and protein aggregation. Biochemistry 20 6365159
1982 Catalytic mechanism of phenylalanyl-tRNA synthetase of Escherichia coli K10. Conformational change and tRNAPhe phenylalanylation are concerted. Biochemistry 19 7046787
2015 KPP: KEGG Pathway Painter. BMC systems biology 18 25879163
2011 Description of the natural course and clinical manifestations of ichthyosis with confetti caused by a novel KRT10 mutation. The British journal of dermatology 18 21929535
2010 Lethal autosomal recessive epidermolytic ichthyosis due to a novel donor splice-site mutation in KRT10. The British journal of dermatology 18 20302579
2020 Ozone therapy promotes the differentiation of basal keratinocytes via increasing Tp63-mediated transcription of KRT10 to improve psoriasis. Journal of cellular and molecular medicine 17 32168425
2003 Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis. The Journal of biological chemistry 17 12566451
1991 Microheterogeneity of rat submaxillary gland kallikrein k10, a member of the kallikrein family. European journal of biochemistry 17 2026164
2011 Heterologous expression, purification and characterization of nitrilase from Aspergillus niger K10. BMC biotechnology 16 21210990
2009 Continuous hydrolysis of 4-cyanopyridine by nitrilases from Fusarium solani O1 and Aspergillus niger K10. Applied microbiology and biotechnology 16 19554325
1990 Differential expression of the epidermal K1 and K10 keratin genes during mouse embryo development. Biochemistry and cell biology = Biochimie et biologie cellulaire 16 1693084
2001 Inhibition of human endogenous retrovirus-K10 protease in cell-free and cell-based assays. The Journal of biological chemistry 15 11278433
2020 Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes. Scientific reports 14 32179842
2013 Increased seroreactivity to HERV-K10 peptides in patients with HTLV myelopathy. Virology journal 14 24365054
2002 Severe abnormalities in the oral mucosa induced by suprabasal expression of epidermal keratin K10 in transgenic mice. The Journal of biological chemistry 14 12119299
1996 Identification of K1/K10 and K5/K14 keratin pairs in human melanoma cell lines. Journal of dermatological science 14 9023704
1975 Regulation of Escherichia coli K10 aminoendopeptidase synthesis. Effects of mutations involved in the regulation of alkaline phosphatase. European journal of biochemistry 14 1107040
2014 Strategy for automated NMR resonance assignment of RNA: application to 48-nucleotide K10. Journal of biomolecular NMR 12 24899400
1994 Expression of keratins K6 and K16 in regenerating mouse epidermis is less restricted by cell replication than the expression of K1 and K10. Epithelial cell biology 12 7534576
1993 A regulatory function for K10 in the establishment of dorsoventral polarity in the Drosophila egg and embryo. Mechanisms of development 12 8518190
2018 Analysis of KRT1, KRT10, KRT19, TP53 and MMP9 expression in pediatric and adult cholesteatoma. PloS one 11 30021014
2013 Retinoids reduce formation of keratin aggregates in heat-stressed immortalized keratinocytes from an epidermolytic ichthyosis patient with a KRT10 mutation*. Acta dermato-venereologica 10 22504942
2005 Altered T cell differentiation and Notch signaling induced by the ectopic expression of keratin K10 in the epithelial cells of the thymus. Journal of cellular biochemistry 10 15786499
2021 Case Report: Uncommon Association of ITGB4 and KRT10 Gene Mutation in a Case of Epidermolysis Bullosa With Pyloric Atresia and Aplasia Cutis Congenita. Frontiers in genetics 9 34306001
2015 Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo. Genetics and molecular research : GMR 9 26125866
2014 Assessing the ability of the 2D Fisher-KPP equation to model cell-sheet wound closure. Mathematical biosciences 9 24657222
2010 Montmorillonite K-10 catalyzed cyclization of N-ethoxycarbonyl-N'-arylguanidines: access to pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole derivatives. Bioorganic & medicinal chemistry letters 9 20570510
2009 Epidermolytic hyperkeratosis with palmoplantar keratoderma in a patient with KRT10 mutation. European journal of dermatology : EJD 9 19443303
1981 Detection of ligand-induced conformational changes in phenylalanyl-tRNA synthetase of Escherichia coli K10 by laser light scattering. Biochemistry 9 7011376
1976 L-Phenylalanine: tRNA ligase of Escherichia coli K10. The effect of O replaced by S substitution on substrate and ligand binding properties of ATP. European journal of biochemistry 9 786618
2023 Effect of montmorillonite K10 clay on RNA structure and function. Biophysical journal 7 37924206
1980 Kinetics of anticooperative binding of phenylalanyl-tRNAPhe and tRNAPhe to phenylalanyl-tRNA synthetase of Escherichia coli K10. Biochemistry 7 6992864
2020 Ichthyosis with confetti caused by new and recurrent mutations in KRT10 associated with varying degrees of keratin 10 mis-localization. Journal of dermatological science 6 32113649
2017 Coexistence of mutations in keratin 10 (KRT10) and the mitochondrial genome in a patient with ichthyosis with confetti and Leber's hereditary optic neuropathy. American journal of medical genetics. Part A 6 28944608
2009 Bullous congenital ichthyosiform erythroderma: a sporadic case produced by a new KRT10 gene mutation. Pediatric dermatology 6 19689541
1997 A keratin K10 gene mutation in a Japanese patient with epidermolytic hyperkeratosis. The Japanese journal of human genetics 6 9184002
1994 Solution structure of the DNA binding octapeptide repeat of the K10 gene product. Protein engineering 6 8029203
2023 KRT10 plays an important role in the release of viral genome from endosomes during H9N2 subtype AIV replication in HeLa cells. Veterinary microbiology 5 37406407
2022 Cytokeratin 10 (CK10) expression in cancer: A tissue microarray study on 11,021 tumors. Annals of diagnostic pathology 5 36029589
2022 Utility of CK8, CK10, CK13, and CK17 in Differential Diagnostics of Benign Lesions, Laryngeal Dysplasia, and Laryngeal Squamous Cell Carcinoma. Diagnostics (Basel, Switzerland) 5 36553210
2021 Post Zygotic, Somatic, Deletion in KERATIN 1 V1 Domain Generates Structural Alteration of the K1/K10 Dimer, Producing a Monolateral Palmar Epidermolytic Nevus. International journal of molecular sciences 5 34199056
2014 Evaluation of specific marker CK13 and CK10/13 combined with APM staining for the diagnosis of amniotic fluid embolism and aspiration. Forensic science international 5 24705378
2011 Montmorillonite K-10 mediated green synthesis of cyano pyridines: Their evaluation as potential inhibitors of PDE4. European journal of medicinal chemistry 5 22217868
2009 Keratin 10 (K10) is expressed suprabasally throughout the limbus of embryonic and neonatal rat corneas, with interrupted expression in the adult limbus. Experimental eye research 5 19344714
2023 The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 4 37295249
2023 Characterization and biocontrol efficacy of lytic phage (KPP-1) that infects multidrug resistant Klebsiella variicola. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 4 37368195
2021 Effect of the deletion of lprG and p55 genes in the K10 strain of Mycobacterium avium subspecies paratuberculosis. Research in veterinary science 4 34087563
2021 Selective Targeting of the Novel CK-10 Nanoparticles to the MDA-MB-231 Breast Cancer Cells. Journal of pharmaceutical sciences 4 34929154
2020 Mutations in KRT10 in epidermolytic acanthoma. Journal of cutaneous pathology 4 32045015
2014 Clinicopathological features and expression of four keratins (K10, K14, K17 and K19) in six cases of eruptive vellus hair cysts. Clinical and experimental dermatology 4 24773427
2000 Recurrent R156H mutation of KRT10 in a Japanese family with bullous congenital ichthyosiform erythroderma. Journal of the European Academy of Dermatology and Venereology : JEADV 4 11204523

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