Affinage

KLF2

Krueppel-like factor 2 · UniProt Q9Y5W3

Length
355 aa
Mass
37.4 kDa
Annotated
2026-06-10
100 papers in source corpus 49 papers cited in narrative 49 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 5/6 claims corpus-supported (83%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KLF2 (LKLF) is a zinc-finger transcription factor that binds gene promoters to program quiescence, vascular integrity, and cell-fate decisions across hematopoietic, endothelial, and other lineages (PMID:9302292, PMID:15718498). In the endothelium it serves as the central effector of mechanosensing: laminar shear stress, transduced through PIEZO1 and P2X4-dependent calcium signaling into a CaMKII-MEKK3-MEK5-ERK5 cascade, induces KLF2 transcription (PMID:35883633, PMID:25563726), and KLF2 in turn reprograms the endothelial transcriptome to enforce an antithrombotic, anti-inflammatory, and quiescent state — directly inducing thrombomodulin and eNOS while restraining tissue factor and PAI-1 (PMID:15718498), suppressing proinflammatory genes via ATF2 (PMID:17244683), repressing the glycolytic regulator PFKFB3 to limit angiogenic sprouting (PMID:25359860), and repressing the pro-migratory effector PAK1 (PMID:25388666). KLF2 and KLF4 act with substantial redundancy to maintain adult vascular integrity, and combined endothelial loss is acutely lethal (PMID:28239661); aberrant gain of MEKK3-KLF2/KLF4 signaling upon loss of the CCM complex drives cerebral cavernous malformation lesions (PMID:27027284). In lymphocytes KLF2 programs the quiescent single-positive T-cell state and maintains viability, in part by repressing c-Myc (PMID:9302292, PMID:11477405), controls trafficking through CD62L and the S1P receptor S1PR1 (PMID:21187410, PMID:25692701), restrains T follicular helper differentiation via S1PR1 and Blimp-1/Bcl-6 (PMID:25692701), and is required to suppress the exhaustion factor TOX while enabling TBET-driven effector differentiation in CD8 T cells (PMID:39946463, PMID:38012417). KLF2 acts as a tumor suppressor in multiple settings, including by repressing GPX4 to license ferroptosis (PMID:34520818) and by antagonizing NF-κB signaling — loss-of-function mutations in its zinc-finger domains that abolish this NF-κB suppression underlie splenic marginal zone lymphoma (PMID:25428260). KLF2 expression is itself maintained by KDM3A-mediated H3K9 demethylation (PMID:26728187) and METTL3-dependent m6A stabilization of its mRNA (PMID:38741032).

Mechanistic history

Synthesis pass · year-by-year structured walk · 21 steps
  1. 1997 High

    Established KLF2's foundational physiological roles by showing it is genetically required both for T-cell quiescence/survival and for vascular wall stabilization during development.

    Evidence Knockout mice with in vivo T-cell phenotyping and vascular morphogenesis analysis by multiple imaging methods

    PMID:9302292 PMID:9367982

    Open questions at the time
    • Did not identify the transcriptional targets mediating quiescence or vessel stabilization
    • Embryonic lethality limited analysis of adult vascular roles
  2. 1998 High

    Extended the essential developmental requirement to erythropoiesis, showing the closely related EKLF cannot compensate for KLF2 loss.

    Evidence Knockout mouse with in vitro fetal liver erythroid colony assay

    PMID:9859212

    Open questions at the time
    • Direct erythroid target genes not defined in this study
    • Mechanism of non-redundancy with EKLF unresolved
  3. 2001 High

    Resolved how KLF2 enforces T-cell quiescence by showing it acts sufficiently and partly through repression of c-Myc.

    Evidence Gain-of-function in Jurkat cells with dominant-negative MadMyc mimicry and c-Myc rescue epistasis

    PMID:11477405

    Open questions at the time
    • Other quiescence effectors beyond c-Myc not enumerated
    • Direct vs. indirect repression of c-Myc not distinguished
  4. 2002 High

    Defined KLF2 as a direct promoter-binding repressor by showing it inhibits PPARγ2 transcription to restrain adipogenesis.

    Evidence Reporter assays, promoter mutational analysis, and EMSA in preadipocytes

    PMID:12426306

    Open questions at the time
    • In vivo relevance to adipose biology not tested
    • Did not address whether repression is direct binding versus cofactor-mediated
  5. 2003 Medium

    Placed KLF2 in a signaling pathway by showing TRAF2/p38 controls its expression independent of NF-κB, with anti-apoptotic consequences.

    Evidence Microarray comparison of TRAF2-/- cells with ectopic-expression rescue and pathway inhibitors

    PMID:12897154

    Open questions at the time
    • Direct transcriptional control of KLF2 by p38 not demonstrated
    • Anti-apoptotic targets downstream of KLF2 not identified
  6. 2004 High

    Identified the cis-element basis of KLF2 antiproliferative activity, mapping induction of p21 to the Sp1-3 site and requiring both activation and inhibitory domains.

    Evidence Tetracycline-inducible expression with luciferase reporter and promoter mutational analysis in Jurkat cells

    PMID:15361832

    Open questions at the time
    • Endogenous p21 regulation by KLF2 in primary cells not tested
    • Domain contributions to other targets not generalized
  7. 2005 High

    Established KLF2 as the shear-stress-responsive master regulator of endothelial antithrombotic and vascular-tone programs.

    Evidence Adenoviral overexpression and siRNA knockdown with clotting assays, plus in vivo carotid collar shear model with laser microdissection

    PMID:15718498 PMID:16049344

    Open questions at the time
    • Upstream mechanosensors transducing shear to KLF2 not yet defined
    • Direct promoter occupancy at thrombomodulin/eNOS not shown in these studies
  8. 2007 Medium

    Provided a mechanism for KLF2 atheroprotection by showing it suppresses proinflammatory genes via inhibition of ATF2 nuclear binding.

    Evidence Genome-wide profiling, ATF2 nuclear binding assay, and siRNA in HUVEC shear experiments

    PMID:17244683

    Open questions at the time
    • Direct biochemical interaction between KLF2 and ATF2 not established
    • Single-lab finding
  9. 2011 High

    Demonstrated direct chromatin occupancy of KLF2 at globin regulatory elements, establishing its role in embryonic/fetal globin gene expression.

    Evidence ChIP in primary embryonic blood cells with conditional KO and transgenic human globin locus models

    PMID:21610079

    Open questions at the time
    • Functional separation of KLF1 versus KLF2 contributions incompletely resolved
    • Cofactors recruited to globin loci not identified
  10. 2010 High

    Defined KLF2's role in B-cell homeostasis and trafficking via control of CD62L and β7-integrin, revealing lineage-specific differences from T cells.

    Evidence B-cell-specific conditional KO with flow cytometry and gene expression analysis

    PMID:21187410

    Open questions at the time
    • Why S1PR1 is minimally affected in B cells unlike T cells unexplained
    • Direct targets controlling B1/marginal-zone partitioning not defined
  11. 2014 High

    Linked KLF2 to endothelial metabolism, showing it represses PFKFB3 to suppress glycolysis and angiogenic sprouting under laminar flow.

    Evidence Seahorse flux, reporter assays, RNA-seq, and endothelial-specific KO with PFKFB3 rescue

    PMID:25359860

    Open questions at the time
    • Whether metabolic and inflammatory programs are independently regulated not resolved
    • Direct PFKFB3 promoter occupancy by KLF2 not shown
  12. 2014 High

    Connected KLF2 to disease by defining IKKβ-regulated, CCM-regulated, and mutation-driven control of KLF2 activity in coagulation and lymphoma.

    Evidence ChIP and KLF2 knockdown for IKKβ-thrombomodulin axis; zebrafish CCM epistasis; whole-exome sequencing with NF-κB reporter assays of mutant KLF2

    PMID:25039491 PMID:25428260 PMID:25625207

    Open questions at the time
    • Mechanism by which zinc-finger mutations specifically lose NF-κB suppression not structurally defined
    • Direct NF-κB target promoters bound by KLF2 not mapped
  13. 2015 Medium

    Resolved the mechanosensory input to KLF2, showing PIEZO1 and P2X4 transduce shear into calcium/CaMKII-MEKK3-ERK5 signaling that drives KLF2 transcription.

    Evidence Endothelial-specific Piezo1 KO, P2X4 siRNA/antagonist and loss-of-function variant, CaMKII-MEKK3 interaction assays in shear experiments

    PMID:25563726 PMID:35883633

    Open questions at the time
    • Relative contributions of PIEZO1 versus P2X4 not integrated
    • Single-lab signaling reconstruction
  14. 2015 High

    Established KLF2 as a checkpoint of T-cell differentiation and trafficking, controlling S1PR1, Blimp-1/Bcl-6, and Tfh versus Th1 fate.

    Evidence Inducible CD4 T-cell deletion and overexpression with in vivo Tfh quantification and gene expression analysis

    PMID:25692701

    Open questions at the time
    • Direct versus indirect induction of Blimp-1, T-bet, GATA3 not all distinguished
    • Promoter occupancy not shown for all targets
  15. 2016 High

    Defined the MEKK3-KLF2/4 gain-of-signaling mechanism underlying CCM lesion formation and confirmed KLF2's homeostatic role in NK-cell survival.

    Evidence Neonatal CCM mouse model with endothelial-specific Mekk3/Klf2/Klf4 KO and human lesion staining; NK-cell KO with proliferation/homing assays

    PMID:27027284 PMID:27114551

    Open questions at the time
    • Rho-activation link between KLF2 and lesion morphology mechanistically incomplete
    • NK homing-receptor targets of KLF2 not all defined
  16. 2016 High

    Identified the epigenetic and autoregulatory circuitry maintaining KLF2, via KDM3A-mediated H3K9 demethylation and a reciprocal KLF2-IRF4 loop in myeloma.

    Evidence siRNA of KDM3A/KLF2/IRF4, H3K9 ChIP, and in vitro/in vivo myeloma models

    PMID:26728187

    Open questions at the time
    • Whether KDM3A directly targets the KLF2 locus versus indirectly not fully resolved
    • Generality of KLF2-IRF4 loop beyond myeloma unknown
  17. 2017 High

    Demonstrated that KLF2 and KLF4 together control adult vascular integrity with dosage redundancy, with combined loss being acutely lethal.

    Evidence Inducible endothelial-specific Klf2/Klf4 double KO with transcriptome and coagulation analysis and gene-dosage testing

    PMID:28239661

    Open questions at the time
    • Division of labor between KLF2 and KLF4 at individual targets not resolved
    • Which transcriptome subset is the lethal driver not pinpointed
  18. 2017 Medium

    Expanded KLF2 mechanism into migration, cardiac remodeling, and pharmacologic induction pathways linking statins, autophagy, and S1PR1.

    Evidence Erk5/MEK5 and PAK1 rescue migration assays; endothelial-specific Klf2 manipulation in cardiac remodeling; statin-Rac1-Rab7-autophagy and S1PR1 ChIP studies

    PMID:25388666 PMID:27545498 PMID:27756792 PMID:28680571 PMID:33408770

    Open questions at the time
    • These axes derive from individual single-lab studies
    • Integration of autophagy feedback with transcriptional output unresolved
  19. 2019 Medium

    Extended KLF2 function to bone, senescence, and protein-interaction mechanisms, including cooperation with FOXO4 and physical interaction with Runx2.

    Evidence Co-IP of KLF2-FOXO4 and KLF2-Runx2, IRF2BP2-KLF2 epistasis in bone cells, and differentiation/senescence assays

    PMID:30429507 PMID:31186082 PMID:31866399

    Open questions at the time
    • Physical interactions rest on single Co-IPs without reciprocal structural validation
    • In vivo bone phenotypes of KLF2 not established here
  20. 2021 Medium

    Established KLF2 as a tumor suppressor and regenerative regulator acting through GPX4-dependent ferroptosis, HK1-dependent metabolism, Vav1-Rac1 axon regrowth, and cilia-Notch cardiac regeneration.

    Evidence KLF2 over/knockdown with GPX4 and HK1 rescue, DRG ChIP/Rac1 assays, and zebrafish cilia/Notch and valvulogenesis epistasis

    PMID:32249387 PMID:34147481 PMID:34363795 PMID:34520818 PMID:34610316

    Open questions at the time
    • Each axis is single-lab and context-specific
    • Whether these reflect a shared KLF2 transcriptional logic is unresolved
  21. 2024 High

    Identified post-transcriptional control of KLF2 by METTL3-dependent m6A stabilization protecting against EndMT, and CRISPR-defined KLF2 as an effector hub suppressing CD8 T-cell exhaustion.

    Evidence m6A-RIP, mRNA stability, m6A-site mutation and endothelial Mettl3 KO; in vivo CRISPR perturbation screen with TOX/TBET analysis and CAR-T chromatin/transcriptome profiling

    PMID:38012417 PMID:38741032 PMID:39946463

    Open questions at the time
    • Interplay between m6A stabilization and KDM3A epigenetic control not integrated
    • Direct KLF2 targets enforcing the anti-exhaustion program not fully mapped

Open questions

Synthesis pass · forward-looking unresolved questions
  • How KLF2 selects between transcriptional activation and repression at individual targets, and how its many context-specific axes (vascular, immune, metabolic, regenerative) reflect a unified set of direct genomic targets, remains unresolved.
  • No genome-wide KLF2 occupancy map integrating cell types reported
  • Cofactor switching between activation and repression not defined
  • Division of labor with KLF4 at the locus level unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 11 GO:0003677 DNA binding 6
Localization
GO:0005634 nucleus 3
Pathway
R-HSA-74160 Gene expression (Transcription) 7 R-HSA-168256 Immune System 6 R-HSA-1266738 Developmental Biology 5 R-HSA-109582 Hemostasis 4 R-HSA-162582 Signal Transduction 4 R-HSA-1430728 Metabolism 2
Partners
ATF2FOXO4HK1IRF4KLF4MEKK3RUNX2

Evidence

Reading pass · 49 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 LKLF/KLF2 is required to program the quiescent state of single-positive T cells and maintain their viability; LKLF-deficient T cells produced by gene targeting had a spontaneously activated phenotype and died from Fas ligand-induced apoptosis in peripheral lymphoid organs. Gene targeting (knockout mouse), in vivo phenotypic analysis of T cell activation and apoptosis Science High 9302292
1997 LKLF/KLF2 expressed in vascular endothelial cells is required for tunica media formation and vessel wall stabilization; LKLF-deficient embryos die from hemorrhage with defects in smooth muscle cell organization, reduced pericytes, and decreased extracellular matrix deposition in vessel walls. Homologous recombination (knockout mouse), in situ hybridization, immunohistochemistry, electron microscopy Genes & development High 9367982
1998 Loss of LKLF/KLF2 causes embryonic lethality with abdominal bleeding, craniofacial abnormalities, and failure of fetal liver erythroid colony formation in vitro, establishing an essential and non-redundant role in embryonic erythropoiesis that cannot be compensated by the closely related EKLF. Gene targeting (knockout mouse), in vitro fetal liver erythroid colony assay Transgenic research High 9859212
2001 Forced expression of LKLF/KLF2 in Jurkat T cells is sufficient to program a quiescent phenotype (decreased proliferation, reduced cell size, decreased activation markers) partly by decreasing c-Myc expression; the effects of LKLF are mimicked by dominant-negative MadMyc and rescued by c-Myc overexpression. Retroviral/plasmid overexpression in Jurkat cells, dominant-negative rescue, gene targeting KO for complementation Nature immunology High 11477405
2002 KLF2 directly inhibits PPARγ2 promoter activity (70% inhibition) by binding a specific site in the PPARγ2 promoter, thereby acting as a negative regulator of adipogenesis by repressing PPARγ as well as downstream factors C/EBPα and SREBP1c; KLF2 had no effect on upstream C/EBPβ or C/EBPδ. Transient transfection reporter assay, promoter mutational analysis, gel mobility shift assay (EMSA), overexpression in preadipocytes and primary cells The Journal of biological chemistry High 12426306
2003 TRAF2 regulates LKLF/KLF2 expression through the p38 MAP kinase pathway (not via TNF signaling or NF-κB); ectopic LKLF expression in TRAF2-deficient cells protected against TNF-induced apoptosis, placing LKLF downstream of TRAF2/p38 in an anti-apoptotic pathway. Microarray gene expression comparison of TRAF2−/− vs. WT cells, ectopic expression rescue, pathway inhibitor analysis Molecular and cellular biology Medium 12897154
2004 KLF2 inhibits proliferation of Jurkat T leukemia cells by upregulating p21WAF1/CIP1 expression; the functional responsive element in the p21 promoter is the Sp1-3 binding site (not the CACCC site), and both activation and inhibitory domains of KLF2 are required for this effect. Tetracycline-inducible expression system, 3H-thymidine uptake assay, luciferase reporter assay, promoter deletion/mutation analysis Oncogene High 15361832
2005 KLF2 regulates endothelial thrombotic function by transcriptionally inducing thrombomodulin and eNOS, reducing PAI-1, and inhibiting cytokine-induced tissue factor expression; siRNA knockdown of KLF2 reduces antithrombotic gene expression and reduces blood clotting time in functional clotting assays. Adenoviral overexpression, siRNA knockdown, gene expression analysis, in vitro clotting assays Circulation research High 15718498
2005 KLF2 (LKLF) is regulated by shear stress in vivo at high-shear arterial sites and acts as a transcriptional regulator of vascular tone genes; KLF2 repression by siRNA suppressed the flow response of endothelin-1, adrenomedullin, and eNOS, establishing KLF2 as a downstream mediator of the shear stress-to-gene expression axis. Carotid artery collar model (in vivo), siRNA knockdown, in situ hybridization, laser microdissection/RT-PCR, shear stress chamber experiments The American journal of pathology High 16049344
2007 KLF2 inhibits proinflammatory gene expression in endothelial cells under laminar shear stress by suppressing nuclear binding activity of ATF2; siRNA knockdown of ATF2 suppressed basal proinflammatory gene expression under no-flow conditions, placing KLF2-mediated ATF2 inhibition as the mechanism of atheroprotection. Genome-wide expression profiling, promoter analysis, ATF2 nuclear binding activity assay, siRNA knockdown, HUVEC shear stress experiments Blood Medium 17244683
2010 B cell-specific KLF2 deficiency leads to decreased expression of trafficking molecules CD62L and β7-integrin, a drastic reduction in the B1 B-cell pool, increased transitional and marginal zone B-cell numbers, increased apoptosis, and impaired proliferation after BCR cross-linking; S1PR1 expression was unexpectedly minimally altered in B cells. B cell-specific conditional KO mouse, flow cytometry, gene expression analysis Proceedings of the National Academy of Sciences of the United States of America High 21187410
2011 KLF1 and KLF2 directly bind the promoters of human ε- and γ-globin genes, mouse Ey- and βh1-globin genes, and the β-globin locus control region in embryonic blood cells, positively regulating embryonic and fetal β-globin gene expression; KLF1 loss reduces H3K9Ac and H3K4me3 marks at these loci. Chromatin immunoprecipitation (ChIP) with embryonic blood cells, conditional KO mouse models, dual transgenic human β-globin locus mouse model The Journal of biological chemistry High 21610079
2014 KLF2 represses PFKFB3 promoter activity, thereby inhibiting endothelial glycolysis under laminar shear stress; KLF2 overexpression reduces glucose uptake, glycolytic enzyme expression (PFKFB3, PFK-1, HK2), and angiogenic sprouting, effects partially reversed by PFKFB3 overexpression. Seahorse flux analysis, glucose uptake assays, RNA sequencing, luciferase reporter assay, siRNA/overexpression, endothelial-specific KLF2 KO mouse Arteriosclerosis, thrombosis, and vascular biology High 25359860
2014 In zebrafish, loss of CCM proteins upregulates klf2 mRNA through a β1 integrin-dependent mechanism (independent of blood flow), which causes enhanced egfl7 expression and angiogenic signaling; downregulation of β1 integrin rescues CCM cardiovascular malformations, establishing a β1 integrin-Klf2-Egfl7 pathway regulated by CCM proteins. Zebrafish CCM morpholino/mutant model, HUVEC siRNA knockdown, in vivo rescue experiments Developmental cell Medium 25625207
2014 KLF2 mutations in splenic marginal zone lymphoma (predominantly in the C-terminal zinc finger domains) inactivate the ability of KLF2 to suppress NF-κB activation by TLR, BCR, BAFFR, and TNFR signaling, as shown by functional assays. Whole exome sequencing, functional NF-κB reporter assays with mutant KLF2 constructs Leukemia Medium 25428260
2015 KLF2 restrains CD4+ T follicular helper (Tfh) cell differentiation through two mechanisms: (1) promoting S1PR1 expression to control T cell localization (S1PR1 downregulation is required for Tfh generation), and (2) inducing Blimp-1 expression which represses Bcl-6, thereby impairing Tfh differentiation; KLF2 also induces T-bet and GATA3 to enhance Th1 differentiation. Inducible KLF2 deletion in activated CD4+ T cells, KLF2 overexpression, gene expression analysis, in vivo Tfh quantification Immunity High 25692701
2016 CCM disease pathogenesis involves gain of MEKK3-KLF2/4 signaling: loss of CCM complex (KRIT1, CCM2, PDCD10) increases MEKK3 kinase activity which elevates KLF2 and KLF4 expression and Rho activity in endothelial cells of CCM lesions; endothelial-specific loss of Mekk3, Klf2, or Klf4 prevents lesion formation and rescues lethality in a neonatal mouse CCM model. Neonatal mouse CCM model, endothelial-specific conditional KO of Mekk3/Klf2/Klf4, human CCM lesion immunostaining, CCM2 disease-causing mutation analysis (abrogates MEKK3 interaction) Nature High 27027284
2016 KDM3A histone demethylase maintains KLF2 expression through H3K9 demethylation at the KLF2 locus; KLF2 directly activates IRF4 transcription, and IRF4 reciprocally upregulates KLF2, forming a positive autoregulatory circuit; KLF2 silencing triggers apoptosis in multiple myeloma cells and decreases ITGB7-dependent cell adhesion to bone marrow stromal cells. siRNA knockdown (KDM3A, KLF2, IRF4), ChIP for H3K9 methylation, in vitro and in vivo MM models, gene expression analysis Nature communications High 26728187
2016 KLF2 is a transcription factor required for homeostatic NK cell proliferation and survival; KLF2 deficiency promotes spontaneous proliferation of immature NK cells and regulates a subset of homing receptors that allow mature NK cells to access IL-15-rich microenvironments; KLF2-deficient NK cells undergo apoptosis due to IL-15 starvation. Gene-targeted KO mouse models, ex vivo NK cell proliferation assays, homing receptor expression analysis Proceedings of the National Academy of Sciences of the United States of America High 27114551
2017 Inducible endothelial-specific deletion of both Klf2 and Klf4 (EC-DKO) causes acute death from myocardial infarction, heart failure, and stroke with profound compromise of vascular integrity and dysregulation of the coagulation system; a single allele of either gene is sufficient for survival, establishing that KLF2 and KLF4 together control a large segment of the endothelial transcriptome essential for vascular integrity. Inducible endothelial-specific double KO mouse (Klf2/Klf4), transcriptome analysis, coagulation assays JCI insight High 28239661
2017 KLF2 inhibits endothelial cell migration by KLF2-dependent transcriptional repression of PAK1 (a pro-migratory Rac/Cdc42 mediator); Erk5 activation (via constitutively active MEK5, statins, or shear stress) decreases PAK1 mRNA and protein through KLF2 but not KLF4; PAK1 re-expression or KLF2 knockdown restores migration in Erk5-activated ECs. Constitutively active MEK5 expression, siRNA knockdown (KLF2, KLF4), PAK1 re-expression rescue, migration assays, statin/shear stress treatment Cardiovascular research Medium 25388666
2014 IKKβ inhibition increases thrombomodulin (TM) expression and function through a KLF2-dependent mechanism: IKKβ inhibition causes KLF2 overexpression and enhanced KLF2 binding to the TM promoter (demonstrated by ChIP); KLF2 knockdown completely attenuates IKKβ-inhibition-mediated TM upregulation. IKKβ chemical inhibitors, siRNA/shRNA knockdown, ChIP assay, luciferase reporter assay, flow cytometry, APC generation assay Journal of thrombosis and haemostasis High 25039491
2015 KLF2 directly binds the AQP1 (aquaporin-1) promoter (demonstrated by ChIP) and positively regulates AQP1 expression in endothelial cells; inflammatory stimuli repress AQP1 in an effect restrained by KLF2 overexpression. Chromatin immunoprecipitation (ChIP), KLF2 overexpression, siRNA, gene expression profiling, immunohistochemistry in human vascular tissue PloS one Medium 26717516
2015 miR-302-367 downregulates Erk1/2, which increases KLF2 expression, which in turn upregulates S1PR1 and VE-cadherin, suppressing angiogenesis and improving vascular stability; this Erk1/2-Klf2-S1pr1 pathway was validated by genetic S1pr1 deletion which reversed the antiangiogenic effects of miR-302-367. Endothelial-specific miR302-367 overexpression in mice, S1pr1 genetic deletion, retinal angiogenesis assay, tumor angiogenesis models Circulation research Medium 27756792
2015 Simvastatin activates KLF2 expression through a Rac1-Rab7-autophagy dependent mechanism; KLF2 induction in turn promotes further activation of autophagy, forming a positive feedback loop; this autophagy-KLF2 relationship modulates endothelial phenotype and survival in acute liver injury. Pharmacological inhibition (GGTI-298, statins, resveratrol), adenoviral KLF2 overexpression, autophagic flux assays, LSEC and HUVEC models, pre-clinical liver I/R models Journal of hepatology Medium 27545498
2018 KLF2 directly regulates osteoblast differentiation by binding to and physically interacting with Runx2, promoting Runx2 expression and activity; KLF2 overexpression increases Alp, Osx, Ocn and mineralization while knockdown has opposite effects. Overexpression and siRNA knockdown in MC3T3-E1 cells and primary osteoblasts, co-immunoprecipitation (KLF2-Runx2 interaction) Laboratory investigation Medium 30429507
2019 KLF2 regulates osteoclastogenesis by modulating Beclin1 (BECN1)-mediated autophagy; KLF2 knockdown increases H3K9 and H4K8 acetylation in the Becn1 promoter region (demonstrated by ChIP), increasing Becn1 expression; KLF2 overexpression reduces these histone acetylation marks and decreases autophagy and osteoclast differentiation. ChIP assay for histone modifications at Becn1 promoter, adenoviral KLF2 overexpression, siRNA knockdown, 3-methyladenine autophagy inhibition, arthritis mouse model Autophagy Medium 30894058
2015 PIEZO1 mechanosensitive channel mediates shear stress-induced KLF2/4 expression through a CaMKII-MEKK3-ERK5 signaling axis: shear stress activates PIEZO1, causing calcium influx that activates CaMKII, which interacts with and activates MEKK3, promoting MEKK3/MEK5/ERK5 signaling to induce KLF2/4 transcription; endothelial-specific Piezo1 deletion reduces KLF2/4 expression in vivo. Endothelial-specific Piezo1 knockout mice, PIEZO1 receptor antagonist, siRNA, CaMKII interaction/activation assays, shear stress experiments Cells Medium 35883633
2015 P2X4 purinergic receptor mediates shear stress-induced KLF2 expression in endothelial cells; shear-induced ATP release activates P2X4, promoting ERK5 phosphorylation and KLF2 upregulation; a loss-of-function P2X4 variant (Tyr315>Cys) blocks ATP-induced KLF2 expression. siRNA knockdown of P2X4, pharmacological P2X4 antagonist, transient transfection of mutant P2X4, HUVEC shear stress experiments Purinergic signalling Medium 25563726
2017 Endothelial KLF2 mediates protection against cardiac maladaptive remodeling via a Klf2-Foxp1-TGFβ1 pathway; endothelial-specific KLF2 inhibition reverses simvastatin-mediated reduction of fibroblast proliferation and myofibroblast formation; KLF2 directly regulates TGFβ1 and Foxp1 in endothelial cells, and loss of Foxp1 phenocopies KLF2 inhibition. Endothelial-specific siRNA delivery via RGD-magnetic nanoparticles in vivo, pressure overload model, gene expression analysis, in vitro EC studies Theranostics Medium 33408770
2020 KLF2 directly promotes Vav1 transcription in adult DRG neurons; increased Vav1 then promotes axon regeneration by activating Rac1 GTPase; Klf2 is induced by retrograde Ca2+ signaling from injured axons, establishing a Klf2-Vav1-Rac1 axis in peripheral nerve regeneration. RNA-seq after sciatic nerve crush, ChIP for KLF2 at Vav1 promoter, siRNA/overexpression knockdown in DRG neurons, Vav1 KO functional rescue Experimental neurology Medium 34147481
2021 KLF2 inhibits ferroptosis in clear cell renal cell carcinoma by transcriptionally repressing GPX4; KLF2 deficiency impairs GPX4 repression, promoting migration and invasion; reverting KLF2 expression in vivo decreases pulmonary metastases, and GPX4 overexpression reverses KLF2-mediated anti-metastatic effects. KLF2 overexpression/knockdown in vitro and in vivo, GPX4 expression analysis, ferroptosis assays, xenograft mouse model Cancer letters Medium 34520818
2020 KLF2 directly binds the IRF4 promoter (demonstrated by dual luciferase reporter gene assay and ChIP) and upregulates IRF4 expression; IRF4 in turn binds the HDAC7 promoter to increase HDAC7 expression, forming a KLF2-IRF4-HDAC7 neuroprotective pathway in hypoxic-ischemic brain damage. Dual luciferase reporter gene assay, ChIP, adenoviral KLF2 overexpression, in vivo HIBD rat model, OGD neuron model Cell death discovery Medium 35091544
2019 IRF2BP2 regulates KLF2 expression; KLF2 overexpression in osteoclast precursors inhibits osteoclast differentiation by downregulating c-Fos, NFATc1, and TRAP, while KLF2 overexpression in osteoblasts enhances differentiation by upregulating Runx2, ALP, and BSP; IRF2BP2 effects on bone cells are reversed by KLF2 downregulation. Overexpression and siRNA knockdown in osteoclast precursor and osteoblast cell lines, differentiation marker assays, epistasis by KLF2 siRNA rescue BMB reports Medium 31186082
2017 Restoring KLF2 expression in the carotid body of heart failure rabbits (via adenoviral transfection) reduces sympathetic nerve activity, arrhythmia incidence, and chemoreflex sensitivity; lentiviral KLF2 siRNA in the carotid body increases chemoreflex sensitivity and sympathetic activation, establishing KLF2 as a regulator of carotid body chemoreflex function. In vivo adenoviral KLF2 transfection and lentiviral siRNA knockdown in carotid body, measurement of ventilation, renal SNA, ECG, arrhythmia, breathing patterns The Journal of physiology Medium 29023738
2022 KLF2 regulates neutrophil NETosis pathway activated by chronic angiotensin II infusion; mechanistically, KLF2 controls neutrophil activation partly through crosstalk with HIF1 signaling; KLF2-dependent NETosis triggers sporadic thrombosis in small myocardial vessels leading to cardiac hypertrophy. Mouse model of Ang II-induced cardiac dysfunction, neutrophil-specific KLF2 manipulation, NET/thrombosis targeting, HIF1 signaling analysis The Journal of clinical investigation Medium 34793333
2020 KLF2 regulates chemoreflex-related carotid body function by modulating BDNF/TrkB pathway in microglial cells under oxygen-glucose deprivation; KLF2 overexpression increases BDNF and TrkB levels and protects against OGD-induced apoptosis; these KLF2 effects are blocked by BDNF/TrkB inhibitor K252a, establishing KLF2 upstream of BDNF/TrkB signaling. Adenoviral KLF2 overexpression in BV2 cells, OGD model, K252a (BDNF/TrkB inhibitor) epistasis, cell viability/apoptosis assays Gene Low 31821872
2021 KLF2 inhibits TGF-β/Smad signaling in hepatocellular carcinoma cells by inhibiting the transcriptional activity of Smad2/3 and Smad4, creating a negative feedback loop; stably expressed KLF2 attenuates TGF-β-induced MMP2 upregulation and cancer cell motility. Luciferase reporter assay for Smad transcriptional activity, stable KLF2 expression, wound-healing and transwell assays, MMP2 expression analysis Acta biochimica et biophysica Sinica Medium 32318691
2020 KLF2 induces KLF2-mediated autophagy in dental pulp-derived stem cells (DPSCs) during osteoblast differentiation; ChIP analysis confirmed KLF2 and active epigenetic marks (H3K27Ac and H3K4me3) are upregulated in the ATG7 promoter region during OB differentiation; a metabolic shift from mitochondrial respiration to glycolysis occurs during OB differentiation. ChIP for KLF2 and histone marks at ATG7 promoter, Seahorse flux analysis, ROS measurements, gain/loss-of-function of KLF2 and autophagy genes (ATG7, BECN1) Redox biology Medium 32777717
2024 METTL3-mediated N6-methyladenosine (m6A) modification of KLF2 mRNA plays a crucial role in protecting pulmonary artery endothelial cells from EndMT; m6A modification stabilizes KLF2 mRNA; mutations in m6A sites of KLF2 mRNA compromise KLF2 expression and its protective effect; KLF2 modulates SM22 expression through direct binding to its promoter. RNA methylation quantification, m6A-RIP-qPCR, mRNA stability assay, m6A site mutation, dual-luciferase assay for KLF2 binding to SM22 promoter, endothelial-specific Mettl3 KO mice Cellular & molecular biology letters Medium 38741032
2017 Simvastatin upregulates S1PR1 transcription via KLF2: simvastatin induces KLF2 recruitment to the S1PR1 promoter (demonstrated by ChIP); KLF2 silencing significantly attenuates simvastatin-induced S1PR1 promoter activity and augmented S1PR1 agonist-mediated barrier enhancement. ChIP for KLF2 at S1PR1 promoter, luciferase reporter assay, siRNA KLF2 knockdown, transendothelial electrical resistance assay, in vivo mouse lung microarray Pulmonary circulation Medium 28680571
2025 KLF2 is required to suppress the exhaustion-promoting transcription factor TOX and to enable TBET to drive effector differentiation during acute LCMV infection; KLF2 KO results in aberrant differentiation to exhausted-like CD8 T cells during acute infection, and KLF2 is necessary to maintain a polyfunctional tumor-specific progenitor state. In vivo CRISPR-Cas9-based perturbation sequencing (~40 TFs), KLF2 KO during LCMV infection, TOX and TBET expression analysis Science High 39946463
2023 In CAR T cells, KLF2 acts as a hub transcription factor in the effector gene network and enhances effector CD8+ T cell differentiation while preventing terminal exhaustion; FOXP1 (hub in stem-like network) and KLF2 (hub in effector network) reciprocally regulate checkpoints of stem-like to effector transition. Single-cell paired chromatin accessibility and transcriptome profiling (ATAC+RNA-seq) in CAR T cells, enhancer network analysis, FOXP1/KLF2 functional perturbations Nature immunology Medium 38012417
2019 KLF2 directly regulates osteoclastogenesis and osteoblast differentiation; IRF2BP2 overexpression suppresses osteoclast differentiation and enhances osteoblast differentiation through KLF2; effects are reversed by downregulating KLF2, establishing IRF2BP2-KLF2 as a regulatory axis in bone homeostasis. Overexpression and siRNA knockdown of IRF2BP2 and KLF2 in bone cells, epistasis rescue, differentiation marker assays BMB reports Medium 31186082
2019 KLF2 interacts with FOXO4 and cooperates with FOXO4 to induce p21 expression and cellular senescence in pancreatic cancer cells; downregulation of either p21 or FOXO4 impairs KLF2-induced senescence. Co-immunoprecipitation (KLF2-FOXO4 interaction), KLF2 overexpression/knockdown, p21 and FOXO4 siRNA knockdown, senescence assays Experimental cell research Medium 31866399
2021 KLF2 interacts with hexokinase 1 (HK1) and inhibits HK1-mediated glucose metabolism reprogramming, thereby suppressing endothelial-to-mesenchymal transition (EndMT); KLF2 mediates the suppressive effect of BDNF on diabetic intimal calcification through this KLF2/HK1 axis. Co-immunoprecipitation (KLF2-HK1 interaction), HK1 knockdown, KLF2 overexpression/knockdown, glycolysis measurements in HUVECs Cellular signalling Medium 33253911 34363795
2015 KLF2 interacts with β-catenin and negatively regulates β-catenin/TCF signaling in pancreatic ductal adenocarcinoma cells, thereby inhibiting cell growth and migration. Co-immunoprecipitation (KLF2-β-catenin), overexpression in PDAC cells, TCF reporter assay, migration/growth assays Tumour biology Low 26449825
2021 In zebrafish, klf2a and klf2b are required for Notch signaling activation in the endocardium and heart regeneration; klf2 gene expression is regulated by primary cilia-dependent mechanosensing of blood flow changes, placing klf2 downstream of primary cilia in a cilia-klf2-Notch axis. Zebrafish heart regeneration model, klf2a/klf2b morpholino knockdown, primary cilia mutants, Notch reporter assays Protein & cell Medium 32249387
2021 In zebrafish valvulogenesis, Erk5-Klf2-Wnt9a signaling (activated by shear stress) drives Wnt9a production, which induces ingression of endocardial cells into cardiac jelly to form abluminal cell populations; this mechanosensitive Klf2 pathway runs in parallel with Notch-Dll4 lateral inhibition to sculpt valve leaflets. Zebrafish valvulogenesis model, klf2 and wnt9a genetic/morpholino manipulations, Notch-Dll4 pathway epistasis, live imaging Cell reports Medium 34610316

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1997 LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. Science (New York, N.Y.) 352 9302292
2005 Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circulation research 324 15718498
1997 The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes & development 309 9367982
2005 Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. The American journal of pathology 290 16049344
2016 Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature 256 27027284
2014 Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3. Arteriosclerosis, thrombosis, and vascular biology 249 25359860
2002 The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. The Journal of biological chemistry 246 12426306
2017 KLF2 and KLF4 control endothelial identity and vascular integrity. JCI insight 201 28239661
2001 Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway. Nature immunology 184 11477405
2015 The transcription factor KLF2 restrains CD4⁺ T follicular helper cell differentiation. Immunity 168 25692701
2017 KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation. International journal of molecular sciences 142 29125549
2014 KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype. Leukemia 139 25428260
2021 KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma. Cancer letters 137 34520818
2015 Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins. Developmental cell 124 25625207
1998 Loss of LKLF function results in embryonic lethality in mice. Transgenic research 123 9859212
2007 Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2. Blood 122 17244683
2004 KLF2 inhibits Jurkat T leukemia cell growth via upregulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1. Oncogene 105 15361832
2016 Cross-talk between autophagy and KLF2 determines endothelial cell phenotype and microvascular function in acute liver injury. Journal of hepatology 99 27545498
2010 Krüppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression. Proceedings of the National Academy of Sciences of the United States of America 98 21187410
2014 The role of the transcription factor KLF2 in vascular development and disease. Progress in molecular biology and translational science 95 24751430
2016 The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival. Nature communications 92 26728187
2007 The role of shear stress on ET-1, KLF2, and NOS-3 expression in the developing cardiovascular system of chicken embryos in a venous ligation model. Physiology (Bethesda, Md.) 91 18073411
2022 KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression. The Journal of clinical investigation 85 34793333
2019 KLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy. Autophagy 85 30894058
2009 N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b. PloS one 78 19495417
2020 Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension. Nature communications 76 32132543
2015 Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency. Stem cell reports 76 26321140
2018 KLF2 regulates osteoblast differentiation by targeting of Runx2. Laboratory investigation; a journal of technical methods and pathology 71 30429507
2022 The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy. Biomedicines 69 35203463
2020 KLF2 regulates dental pulp-derived stem cell differentiation through the induction of mitophagy and altering mitochondrial metabolism. Redox biology 64 32777717
2020 BDNF corrects NLRP3 inflammasome-induced pyroptosis and glucose metabolism reprogramming through KLF2/HK1 pathway in vascular endothelial cells. Cellular signalling 64 33253911
2023 FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells. Nature immunology 62 38012417
2020 Transcription Factor KLF2 and Its Role in the Regulation of Inflammatory Processes. Biochemistry. Biokhimiia 62 32079517
2025 KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection. Science (New York, N.Y.) 56 39946463
2016 Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival. Proceedings of the National Academy of Sciences of the United States of America 55 27114551
2014 Erk5 inhibits endothelial migration via KLF2-dependent down-regulation of PAK1. Cardiovascular research 51 25388666
2005 Identification of LKLF-regulated genes in quiescent CD4+ T lymphocytes. Molecular immunology 49 15607822
2022 Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells. Cells 48 35883633
2021 The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction. Signal transduction and targeted therapy 48 34253708
2023 KLF2 inhibits colorectal cancer progression and metastasis by inducing ferroptosis via the PI3K/AKT signaling pathway. The journal of pathology. Clinical research 47 37147883
2019 The GLP-1 receptor agonist liraglutide protects against oxidized LDL-induced endothelial inflammation and dysfunction via KLF2. IUBMB life 47 30969479
2019 KLF2 regulates eNOS uncoupling via Nrf2/HO-1 in endothelial cells under hypoxia and reoxygenation. Chemico-biological interactions 46 30928399
2022 Ferutinin induces osteoblast differentiation of DPSCs via induction of KLF2 and autophagy/mitophagy. Cell death & disease 45 35552354
2018 Long noncoding RNA SNHG6 promotes osteosarcoma cell proliferation through regulating p21 and KLF2. Archives of biochemistry and biophysics 45 29608878
2015 SUZ12 promotes gastric cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 45 25672609
2021 Krüppel-like Factor 2 (KLF2) in Immune Cell Migration. Vaccines 44 34696279
2023 HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells. Circulation 43 38099436
2016 A MicroRNA302-367-Erk1/2-Klf2-S1pr1 Pathway Prevents Tumor Growth via Restricting Angiogenesis and Improving Vascular Stability. Circulation research 42 27756792
2021 Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice. British journal of pharmacology 41 34713437
2020 Primary cilia mediate Klf2-dependant Notch activation in regenerating heart. Protein & cell 40 32249387
2015 Shear stress modulates endothelial KLF2 through activation of P2X4. Purinergic signalling 40 25563726
2011 Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding. The Journal of biological chemistry 39 21610079
2021 Mechanosensitive Notch-Dll4 and Klf2-Wnt9 signaling pathways intersect in guiding valvulogenesis in zebrafish. Cell reports 35 34610316
2023 FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses. International journal of biological sciences 33 37705747
2021 Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling. Theranostics 33 33408770
2017 KLF2 inhibits cell growth via regulating HIF-1α/Notch-1 signal pathway in human colorectal cancer HCT116 cells. Oncology reports 33 28628187
2020 KLF2 regulates neutrophil migration by modulating CXCR1 and CXCR2 in asthma. Biochimica et biophysica acta. Molecular basis of disease 32 32800946
2023 Induction of KLF2 by Exercise Activates eNOS to Improve Vasodilatation in Diabetic Mice. Diabetes 31 37347764
2020 KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma. Acta biochimica et biophysica Sinica 30 32318691
2019 Klf4, Klf2, and Zfp148 activate autophagy-related genes in smooth muscle cells during aortic aneurysm formation. Physiological reports 30 31025534
2017 KLF2 attenuates bleomycin-induced pulmonary fibrosis and inflammation with regulation of AP-1. Biochemical and biophysical research communications 30 29079188
2021 Metformin attenuates atherosclerosis and plaque vulnerability by upregulating KLF2-mediated autophagy in apoE-/- mice. Biochemical and biophysical research communications 29 33915432
2018 KLF2 Inhibits the Migration and Invasion of Prostate Cancer Cells by Downregulating MMP2. American journal of men's health 29 30520325
2015 KLF2 is downregulated in pancreatic ductal adenocarcinoma and inhibits the growth and migration of cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 29 26449825
2019 The IRF2BP2-KLF2 axis regulates osteoclast and osteoblast differentiation. BMB reports 28 31186082
2017 KLF2 mediates enhanced chemoreflex sensitivity, disordered breathing and autonomic dysregulation in heart failure. The Journal of physiology 28 29023738
2014 KLF2--a negative regulator of pre-B cell clonal expansion and B cell activation. PloS one 28 24874925
2021 Chrysin boosts KLF2 expression through suppression of endothelial cell-derived exosomal microRNA-92a in the model of atheroprotection. European journal of nutrition 27 34041583
2019 KLF2 protects BV2 microglial cells against oxygen and glucose deprivation injury by modulating BDNF/TrkB pathway. Gene 27 31821872
2015 Disturbed shear stress reduces Klf2 expression in arterial-venous fistulae in vivo. Physiological reports 26 25780089
2003 TRAF2 exerts its antiapoptotic effect by regulating the expression of Krüppel-like factor LKLF. Molecular and cellular biology 26 12897154
2024 N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension. Cellular & molecular biology letters 25 38741032
2020 Artesunate inhibits atherosclerosis by upregulating vascular smooth muscle cells-derived LPL expression via the KLF2/NRF2/TCF7L2 pathway. European journal of pharmacology 25 32739175
2024 Engineering microvascular networks using a KLF2 reporter to probe flow-dependent endothelial cell function. Biomaterials 23 38971122
2020 The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models. Blood advances 23 32191808
2020 DT-13 induced apoptosis and promoted differentiation of acute myeloid leukemia cells by activating AMPK-KLF2 pathway. Pharmacological research 23 32416217
2011 Krüppel-like factors KLF2 and 6 and Ki-67 are direct targets of zoledronic acid in MCF-7 cells. Bone 22 22166808
2023 Down-regulation of KLF2 in lung fibroblasts is linked with COVID-19 immunofibrosis and restored by combined inhibition of NETs, JAK-1/2 and IL-6 signaling. Clinical immunology (Orlando, Fla.) 21 36693535
2021 G protein-coupled estrogen receptor regulates the KLF2-dependent eNOS expression by activating of Ca2+ and EGFR signaling pathway in human endothelial cells. Biochemical pharmacology 21 34363795
2017 Vascular protective effects of KLF2 on Aβ-induced toxicity: Implications for Alzheimer's disease. Brain research 21 28130053
2014 IKKβ regulates endothelial thrombomodulin in a Klf2-dependent manner. Journal of thrombosis and haemostasis : JTH 21 25039491
2014 Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation. Haematologica 21 25150253
2021 Azilsartan ameliorates ox-LDL-induced endothelial dysfunction via promoting the expression of KLF2. Aging 20 33946046
2015 Expression of Nitric Oxide-Transporting Aquaporin-1 Is Controlled by KLF2 and Marks Non-Activated Endothelium In Vivo. PloS one 20 26717516
2024 CircFndc3b Mediates Exercise-Induced Neuroprotection by Mitigating Microglial/Macrophage Pyroptosis via the ENO1/KLF2 Axis in Stroke Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 19 39467260
2022 KLF2 up-regulates IRF4/HDAC7 to protect neonatal rats from hypoxic-ischemic brain damage. Cell death discovery 19 35091544
2022 miR-126-5p enhances radiosensitivity of lung adenocarcinoma cells by inhibiting EZH2 via the KLF2/BIRC axis. Journal of cellular and molecular medicine 19 35322532
2022 KLF2 mediates the suppressive effect of BDNF on diabetic intimal calcification by inhibiting HK1 induced endothelial-to-mesenchymal transition. Cellular signalling 19 35364229
2021 MiR-144-induced KLF2 inhibition and NF-kappaB/CXCR1 activation promote neutrophil extracellular trap-induced transfusion-related acute lung injury. Journal of cellular and molecular medicine 19 34120407
2021 Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury. Experimental neurology 19 34147481
2019 KLF2+ stemness maintains human mesenchymal stem cells in bone regeneration. Stem cells (Dayton, Ohio) 19 31721356
2017 AMPK-KLF2 signaling pathway mediates the proangiogenic effect of erythropoietin in endothelial colony-forming cells. American journal of physiology. Cell physiology 19 28978525
2024 TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA. Nature communications 18 39375377
2023 Calenduloside e modulates macrophage polarization via KLF2-regulated glycolysis, contributing to attenuates atherosclerosis. International immunopharmacology 18 36878047
2022 Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis. Blood 18 35245372
2020 Long non-coding RNA AFAP1-AS1 promotes proliferation and migration of gastric cancer by downregulating KLF2. European review for medical and pharmacological sciences 18 32016968
2020 Betulinic Acid Induces eNOS Expression via the AMPK-Dependent KLF2 Signaling Pathway. Journal of agricultural and food chemistry 18 33232606
2019 KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21. Experimental cell research 17 31866399
2021 Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. FASEB bioAdvances 16 33977234
2017 Simvastatin-induced sphingosine 1-phosphate receptor 1 expression is KLF2-dependent in human lung endothelial cells. Pulmonary circulation 16 28680571

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