JPH4
Junctophilin-4 · UniProt Q96JJ6
- Length
- 628 aa
- Mass
- 65.9 kDa
- Annotated
- 2026-06-10
19 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 19 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2009 | The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair. | In vivo (Athens, Greece) | 46 | 19779106 |
| 2011 | GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi anemia cell lines. | Radiation research | 37 | 21939290 |
| 2014 | Amelioration of radiation-induced oral cavity mucositis and distant bone marrow suppression in fanconi anemia Fancd2-/- (FVB/N) mice by intraoral GS-nitroxide JP4-039. | Radiation research | 34 | 24932534 |
| 2016 | Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice. | Radiation research | 32 | 26789701 |
| 2018 | The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice. | Scientific reports | 20 | 29391546 |
| 2018 | Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca-/- and Fancg-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039). | Radiation research | 19 | 29584588 |
| 2020 | The mitochondrial-targeted reactive species scavenger JP4-039 prevents sulfite-induced alterations in antioxidant defenses, energy transfer, and cell death signaling in striatum of rats. | Journal of inherited metabolic disease | 14 | 32882059 |
| 1997 | Implementation of natural attenuation at a JP-4 jet fuel release after active remediation. | Biodegradation | 11 | 9523452 |
| 2025 | JP4-039 protects chondrocytes from ferroptosis to attenuate osteoarthritis progression by promoting Pink1/Parkin-dependent mitophagy. | Journal of orthopaedic translation | 10 | 40129610 |
| 2014 | Improved hematopoiesis in GS-nitroxide (JP4-039)-treated mouse long-term bone marrow cultures and radioresistance of derived bone marrow stromal cell lines. | In vivo (Athens, Greece) | 9 | 25189880 |
| 2020 | Fanconi Anemia Mouse Genotype-specific Mitigation of Total Body Irradiation by GS-Nitroxide JP4-039. | In vivo (Athens, Greece) | 8 | 31882460 |
| 2017 | Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma. | Journal of pharmaceutical and biomedical analysis | 7 | 29245086 |
| 2017 | Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350. | In vivo (Athens, Greece) | 6 | 28358695 |
| 2025 | Mitochondria-targeted ROS scavenger JP4-039 improves cardiac function in a post-myocardial infarction animal model and induces angiogenesis in vitro. | PloS one | 5 | 40273045 |
| 2024 | Mitigation of Fetal Radiation Injury from Mid-Gestation Total-body Irradiation by Maternal Administration of Mitochondrial-Targeted GS-Nitroxide JP4-039. | Radiation research | 4 | 39074819 |
| 2025 | Characterization of a novel Jumbo phage JP4 with potential to control pathogenic Escherichia coli. | Virology journal | 2 | 41291724 |
| 2024 | JP4-039, a Mitochondria-Targeted Nitroxide, Mitigates the Effect of Apoptosis and Inflammatory Cell Migration in the Irradiated Mouse Retina. | International journal of molecular sciences | 2 | 38928220 |
| 2026 | Complete genome sequence of polyurethane-degrading Aeromicrobium sp. JP4. | Microbiology resource announcements | 0 | 42117680 |
| 2024 | Mitigation of Fetal Irradiation Injury from Mid-Gestation Total Body Radiation with Mitochondrial-Targeted GS-Nitroxide JP4-039. | bioRxiv : the preprint server for biology | 0 | 38405696 |
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