Affinage

IL2RB

Interleukin-2 receptor subunit beta · UniProt P14784

Length
551 aa
Mass
61.1 kDa
Annotated
2026-06-10
100 papers in source corpus 25 papers cited in narrative 25 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IL2RB encodes IL-2Rβ (CD122), the shared signaling subunit of the IL-2 and IL-15 receptor complexes that transduces cytokine engagement through the JAK1/STAT5 axis to control lymphocyte development, homeostasis, and effector fate (PMID:40570369, PMID:40750242). The amount of CD122 displayed on the cell surface acts as a tunable rheostat for IL-2/IL-15 responsiveness: graded signaling strength partitions CD8+ T cell fate, with weak CD122 signaling supporting central-memory survival via Bcl-2-like pro-survival programs and stronger signaling driving effector-memory development (PMID:21984699), and high-affinity IL-15 (but not IL-2) signaling through CD122 underlying costimulation-independent memory recall (PMID:30222140). Surface abundance itself is set both transcriptionally and post-translationally—Runx3 drives CD122 expression during NK differentiation (PMID:18003603), IL-27 upregulates CD122 to maintain Treg competitive fitness (PMID:41364763), ADAM17 sheddase cleaves membrane CD122 to dampen IL-2/IL-15 signaling (PMID:38918390), and FUT8-mediated core fucosylation is required for CD122 surface expression and IL-15 signaling in NK cells (PMID:40753573); correspondingly, CD122 levels constrain lymphopenia-induced proliferation by limiting IL-15 responsiveness (PMID:32393513). CD122 marks a naturally occurring CD8+CD122+PD-1+ regulatory T cell subset that suppresses activated T cells through two distinct mechanisms—IL-10-dependent suppression of proliferation and Fas/FasL-dependent cytotoxic killing—following MHC class I–αβTCR recognition of activated targets and CD80/CD86–CD28 co-stimulation (PMID:15520244, PMID:16301610, PMID:18495626, PMID:18205792, PMID:26869716). Continuous CD122/STAT5 signaling sustains natural Tregs during thymic selection (PMID:21541329). Human hypomorphic IL2RB mutation in the WSXWS motif reduces IL-2Rβ surface expression and STAT5 signaling, causing multisystem autoimmunity, reduced Tregs, and aberrant NK maturation, establishing CD122 as non-redundantly required for peripheral tolerance and NK development (PMID:31040184, PMID:40570369).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2004 High

    Established that CD122 surface expression marks a functional CD8+ regulatory T cell population essential for T cell homeostasis, defining a non-conventional immunoregulatory role beyond cytokine reception.

    Evidence Adoptive transfer of CD8+CD122+ cells into CD122-deficient neonatal mice plus in vitro suppression assays

    PMID:15520244

    Open questions at the time
    • Did not define the molecular mechanism of suppression
    • Did not establish how CD122 expression itself contributes to the regulatory program
  2. 2005 High

    Identified IL-10 as the soluble effector by which CD8+CD122+ Tregs suppress target T cell proliferation and IFN-γ production, providing a first defined suppressive mechanism.

    Evidence In vitro co-culture, neutralizing antibody blockade, cytokine depletion, and IL-10-KO mice

    PMID:16301610

    Open questions at the time
    • Did not address whether other suppressive pathways operate in vivo
    • Did not link IL-10 production to specific activation signals
  3. 2008 High

    Defined the activation requirements of CD8+CD122+ Tregs, showing antigen-specific MHC class I–αβTCR recognition of activated targets and CD80/CD86–CD28 co-stimulation are both needed to trigger IL-10-mediated suppression.

    Evidence In vitro co-culture with MHC-congenic strains, blocking antibodies, and CD28-KO cells

    PMID:18205792 PMID:18495626

    Open questions at the time
    • Did not resolve which TCR specificities are involved
    • Did not connect activation route to the choice between IL-10 and cytotoxic mechanisms
  4. 2010 High

    Resolved the regulatory versus memory heterogeneity within CD8+CD122+ cells, identifying PD-1+ cells as the suppressive subset and PD-1 as a required co-signal for optimal IL-10 production.

    Evidence PD-1 subset fractionation with in vitro and in vivo suppression assays and antibody blockade

    PMID:20548035

    Open questions at the time
    • Did not define how PD-1 signaling mechanistically augments IL-10 output
    • Did not reconcile PD-1 requirement with earlier finding that PD-1 was dispensable
  5. 2016 High

    Uncovered a second, IL-10-independent suppressive mechanism—Fas/FasL-dependent cytotoxic killing—operating in the CD49d(low) regulatory subset, establishing dual-pathway suppression.

    Evidence In vitro and in vivo assays using lpr/gld mutant mice, CD49d fractionation, and IL-10-KO Tregs

    PMID:26869716

    Open questions at the time
    • Did not define what dictates use of cytotoxic versus IL-10 pathway
    • Did not address relative in vivo contributions of the two mechanisms
  6. 2017 High

    Mapped the two suppressive mechanisms to distinct contexts, showing FasL-mediated killing dominates allograft suppression in vivo while IL-10 mediates suppression of proliferation in vitro.

    Evidence Adoptive transfer transplant model with Fas-KO/FasL-KO strains and in vitro cytotoxicity assays

    PMID:28445940

    Open questions at the time
    • Did not define molecular switch governing pathway selection
    • Did not test clinical translatability of the suppressive subset
  7. 2011 High

    Demonstrated that CD122 signaling strength is decoded into distinct CD8+ memory fates—weak signals supporting central-memory survival via Bcl-2-like programs, stronger signals driving effector-memory development.

    Evidence Knock-in mice with CD122 tail mutations, Bcl-2 transgenic/CD122-KO chimeras, and in vivo OT-I tracking

    PMID:21984699

    Open questions at the time
    • Did not identify the discrete signaling thresholds
    • Did not separate IL-2 from IL-15 contributions to each fate
  8. 2018 High

    Distinguished IL-2 from IL-15 dependence of CD122 function, showing high-affinity IL-15 receptor signaling through CD122 drives costimulation-independent memory CD8+ recall while IL-2 high-affinity signaling is dispensable.

    Evidence Murine and nonhuman primate transplant models with CD122-selective blockade

    PMID:30222140

    Open questions at the time
    • Did not define the structural basis of IL-2 versus IL-15 discrimination through the shared β-chain
    • Did not establish downstream effectors of recall signaling
  9. 2020 High

    Established surface CD122 abundance as a quantitative gate on IL-15 responsiveness and homeostatic proliferation, with low CD122 limiting naive CD4 T cell expansion.

    Evidence Quantitative surface flow cytometry, IL-2Rβ transgenic CD4 T cells, and lymphopenia-induced proliferation assays

    PMID:32393513

    Open questions at the time
    • Did not identify what sets the differential CD122 expression between CD4 and CD8 cells
    • Did not address post-translational contributions to surface abundance
  10. 2024 High

    Identified ADAM17-mediated ectodomain shedding as a post-translational brake on CD122 surface abundance, tuning IL-2/IL-15 signaling and effector CD8+ differentiation in mouse and human cells.

    Evidence T cell-specific ADAM17 conditional KO, transcriptomics/proteomics, and human CD8+ ADAM17 inhibition

    PMID:38918390

    Open questions at the time
    • Did not define the precise cleavage site on CD122
    • Did not establish physiological cues triggering shedding
  11. 2025 High

    Identified FUT8-mediated core fucosylation as a glycosylation requirement for CD122 surface expression and IL-15 signaling in NK cells, controlling NK homeostasis, cytotoxicity, and antitumor/antiviral immunity.

    Evidence Genome-wide CRISPR screen in human NK cells plus conditional NK-specific Fut8-KO mice with functional readouts

    PMID:40753573

    Open questions at the time
    • Did not determine which CD122 N-glycans are fucosylated
    • Did not test whether fucosylation regulates CD122 in non-NK lineages
  12. 2025 High

    Confirmed in a humanized knockin model that hypomorphic IL2RB reduces surface expression and STAT5 signaling, revealing distinct CD122 signaling thresholds for Tregs versus CD8+ T cells that underlie autoimmunity from impaired tolerance.

    Evidence Homologous knockin mouse, mixed bone marrow chimeras, neonatal WT Treg transfer, and STAT5 phosphorylation assays

    PMID:40570369

    Open questions at the time
    • Did not define the molecular basis of the cell-type-specific threshold difference
    • Did not fully resolve the Treg-extrinsic restoring mechanism
  13. 2025 Medium

    Established IL-27 as an upstream inducer of CD122 on Tregs that sustains their IL-2/IL-15 responsiveness and competitive fitness during homeostasis.

    Evidence Mixed IL-27R-sufficient/deficient Treg chimeras, aging experiments, in vivo CD122 blockade, and in vitro IL-27 stimulation

    PMID:41364763

    Open questions at the time
    • Did not define the transcriptional path from IL-27R to IL2RB
    • Single-lab study without independent confirmation

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the shared β-chain structurally and biochemically discriminates IL-2 versus IL-15 inputs to generate distinct cell-fate outcomes, and how transcriptional, glycosylation, and shedding inputs are integrated to set surface CD122 thresholds in each lineage, remains unresolved.
  • No structural model of differential ligand discrimination through CD122 in the corpus
  • No unified quantitative framework linking the multiple CD122 abundance regulators to threshold setting

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0048018 receptor ligand activity 2 GO:0140110 transcription regulator activity 2
Localization
GO:0005886 plasma membrane 4
Pathway
R-HSA-168256 Immune System 4 R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 3
Partners
ADAM17FUT8IL2RGJAK1STAT5
Complex memberships
IL-15 receptor complexIL-2 receptor complex

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 CD8+CD122+ T cells function as naturally occurring regulatory T cells that suppress activated CD8+ and CD4+ T cells both in vivo and in vitro; transfer of CD8+CD122+ cells into CD122-deficient neonates prevented development of abnormal (hyperactivated) T cells, establishing CD122 (IL-2Rβ) as a marker of this regulatory population essential for T cell homeostasis. Adoptive cell transfer into CD122-deficient neonatal mice; in vitro suppression assays The Journal of experimental medicine High 15520244
2005 CD8+CD122+ regulatory T cells suppress proliferation and IFN-γ production of CD8+ target T cells via secretion of IL-10; blockade of IL-10 (but not TGF-β) abrogated suppression, and CD8+CD122+ cells from IL-10-deficient mice lacked regulatory activity. In vitro co-culture suppression assays; neutralizing antibody blockade; cytokine-removal from conditioned medium; IL-10-KO mice Journal of immunology (Baltimore, Md. : 1950) High 16301610
2008 CD8+CD122+ regulatory T cells recognize already-activated target T cells through MHC class I–αβTCR–CD8 interactions (not Qa-1 or I-A); this recognition activates Tregs to produce IL-10 and suppress IFN-γ. MHC-congenic experiments confirmed MHC restriction; blocking antibodies against H-2K, H-2D, αβTCR, or CD8 on either Treg or target cells abolished suppression. In vitro co-culture with MHC-congenic/allogeneic mouse strains; surface molecule blocking antibodies International immunology High 18495626
2008 CD80/CD86–CD28 co-stimulatory interactions are required for CD8+CD122+ Tregs to become activated and produce IL-10; blocking CD80, CD86, or CD28 prevented IL-10 production and suppression of target T cells, and CD8+CD122+ cells from CD28-KO mice lacked regulatory activity. CTLA-4, ICOS, and PD-1 were not involved. Neutralizing antibody blockade of costimulatory molecules; CD28-KO mouse cells; in vitro suppression assays Immunology High 18205792
2010 Within the CD8+CD122+ population, PD-1+ cells are the regulatory subset (producing IL-10 and suppressing T cell responses), while PD-1− cells are bona fide memory T cells; suppression by PD-1+ cells requires both CD28 and PD-1 co-stimulatory signaling for optimal IL-10 production. In vitro and in vivo suppression assays; PD-1 subset fractionation; antibody blockade Journal of immunology (Baltimore, Md. : 1950) High 20548035
2016 CD8+CD122+CD49d(low) cells are the bona fide regulatory T cell subset within CD8+CD122+ T cells; their suppression of activated T cells operates via Fas/FasL (CD95/CD178)-dependent cytotoxic killing. Tregs from gld (FasL-deficient) mice failed to suppress wild-type targets; targets from lpr (Fas-deficient) mice resisted suppression. IL-10 was found dispensable for this killing mechanism. In vitro and in vivo regulatory assays using lpr/gld mutant mice; CD49d subset fractionation; IL-10-KO Tregs Proceedings of the National Academy of Sciences of the United States of America High 26869716
2017 CD8+CD122+PD-1+ Tregs suppress allograft rejection primarily via Fas ligand-mediated killing of effector T cells in vivo; suppression was largely abolished when Tregs lacked FasL or when effector T cells lacked Fas. In contrast, IL-10 (not FasL) mediates their suppression of T cell proliferation in vitro. Adoptive T cell transfer model in lymphocyte-deficient mice; FasL-blocking antibodies; Fas-deficient and FasL-deficient genetic mouse strains; in vitro cytotoxicity assays Oncotarget High 28445940
2019 A homozygous hypomorphic mutation in the WSXWS motif of human IL2RB results in diminished IL-2Rβ surface expression and dysregulated IL-2/IL-15 signaling, manifesting as multisystem autoimmunity, reduced regulatory T cells, and an expanded CD56bright NK cell population with lack of terminally differentiated NK cells. Human patient genetic analysis; flow cytometry of immune subsets; functional signaling assays in patient cells The Journal of experimental medicine High 31040184
2011 Weak CD122-dependent signaling supports CD8+ T central-memory (TCM) cell survival largely through pro-survival (Bcl-2-like) signals, whereas stronger CD122 signaling is required for T effector-memory (TEM) development. This was demonstrated using mouse models with mutations attenuating CD122 cytoplasmic tail signaling and Bcl-2 transgenic CD122-KO CD8+ T cells. Knock-in mice with CD122 cytoplasmic tail mutations; Bcl-2 transgenic/CD122-KO mixed bone marrow chimeras; in vivo OT-I T cell response tracking Journal of immunology (Baltimore, Md. : 1950) High 21984699
2018 CD122 (IL-2Rβ) signaling drives costimulation-independent rejection by CD8+ memory T cells; high-affinity IL-15 receptor signaling through CD122 was critical for costimulation-independent memory CD8+ T cell recall, while IL-2 high-affinity receptor signaling was dispensable. Combined CD122 blockade and costimulatory blockade prolonged transplant survival in mice and nonhuman primates. Murine and nonhuman primate transplant models; CD122-selective blocking antibody; mechanistic dissection of IL-2 vs. IL-15 receptor dependence; antibody-mediated depletion/blockade The Journal of clinical investigation High 30222140
2007 Runx3 transcription factor binds to the promoter region of the CD122 (IL2RB) gene and drives its expression during NK cell differentiation; introduction of a dominant-negative Runx form into hematopoietic stem cells decreased CD122 expression in NK cell-inducing culture. Dominant-negative Runx transgenic mice; chromatin binding (Runx binds CD122 promoter by PCR/binding assay); NK cell differentiation culture system International immunology Medium 18003603
2001 Fibroblast-like synoviocytes (FLS) express functional IL-2Rβ (CD122) and IL-2Rγ (CD132) but not CD25; IL-2 stimulation through CD122 on FLS induces MCP-1 (monocyte chemoattractant protein-1) production via tyrosine phosphorylation signaling, and neutralizing anti-CD122 antibody partially blocked IL-2-induced MCP-1 secretion. Flow cytometry; RT-PCR; anti-CD122 neutralizing antibody blockade; MCP-1 ELISA; tyrosine phosphorylation western blot after IL-2 stimulation Journal of immunology (Baltimore, Md. : 1950) Medium 11238664
1996 CD122 (IL-2Rβ) is expressed on early lymphoid progenitors including Sca1+Lin- hematopoietic stem cells in fetal liver and intrathymic T cell progenitors; prepro-B cells (CD43+CD24- fraction A) express CD122 and proliferate vigorously in response to IL-2 but not IL-15 in the absence of stromal cells, implicating IL-2/CD122 signaling in early lymphocyte development. Flow cytometry of fetal liver and thymus; in vitro proliferation assays with IL-2 or IL-15; embryo section localization Blood Medium 8547641
2011 CD122 (IL-2Rβ)/STAT-5 signaling is continuously active in natural regulatory T cells (Tregs) during thymic selection; pSTAT-5 levels correlated with CD122 and Foxp3 expression (more than with CD25), and IL-2/IL-15 (not IL-7) drove STAT-5 phosphorylation in Treg-lineage cells ex vivo. Ex vivo phospho-flow cytometry of murine thymocytes; in vitro cytokine stimulation; neonatal thymus time-course analysis PloS one Medium 21541329
2020 The abundance of IL-2Rβ (CD122) on the cell surface constrains lymphopenia-induced homeostatic proliferation (LIP) of naive CD4 T cells; naive CD4 T cells express ~5-fold less CD122 than CD8 T cells, limiting IL-15 responsiveness. Forced IL-2Rβ expression by transgenesis bestowed IL-15 responsiveness on CD4 T cells and enabled robust LIP. Quantitative flow cytometry of surface CD122; IL-2Rβ transgenic CD4 T cells; lymphopenia-induced proliferation assays in mice Journal of immunology (Baltimore, Md. : 1950) High 32393513
2021 IL-2Rβ (CD122) timing and abundance of expression control thymic iNKT cell generation and NKT1 subset differentiation; premature CD122 expression was detrimental to iNKT development, while elevated abundance of CD122 suppressed NKT1 (but not NKT2 or NKT17) generation, establishing cytokine receptor expression level as a determinant of iNKT lineage fate. Transgenic mouse models with premature or elevated CD122 expression; thymic iNKT cell subset quantification by flow cytometry Frontiers in immunology Medium 34054809
2024 ADAM17 (a disintegrin and metalloprotease) cleaves membrane CD122 as a sheddase, reducing CD122 surface expression and dampening IL-2 and IL-15 signaling in CD8+ T cells; T cell-specific ADAM17 deletion increased CD122 surface expression, enhanced IL-2/IL-15 responsiveness, and augmented effector CD8+ T cell differentiation in both mouse and human CD8+ T cells. T cell-specific ADAM17 conditional knockout mice; transcriptomic and proteomic analysis; flow cytometry; in vitro IL-2/IL-15 stimulation assays; human CD8+ T cell ADAM17 inhibition Signal transduction and targeted therapy High 38918390
2025 Core fucosylation of IL-2Rβ (CD122) by fucosyltransferase 8 (FUT8) is required for CD122 surface expression and IL-15 receptor signaling in NK cells; NK cell-specific Fut8 deletion caused severe NK lymphopenia with reduced CD122 expression, impaired homeostatic proliferation, decreased cytotoxicity, and impaired tumor and viral immunity. Genome-wide CRISPR screen in human NK cells identifying FUT8; conditional NK cell-specific Fut8-KO mice (Fut8fl/flNcr1cre/+); flow cytometry; in vivo homeostatic proliferation; cytotoxicity and infection assays Cell reports High 40753573
2025 A hypomorphic IL2RB mutation reduces IL-2Rβ cell-surface expression and impairs IL-2/IL-15-dependent STAT5 signaling, leading to elevated serum IL-2/IL-15, expanded effector memory CD8+ T cells, and severely reduced Tregs; mixed bone marrow chimera and wild-type Treg neonatal transfer experiments demonstrated that Tregs and CD8+ T cells have distinct IL-2Rβ signaling thresholds, and that Treg-extrinsic mechanisms can partly restore conventional T cell distribution. Homologous knockin mouse model; mixed bone marrow chimeras; neonatal WT Treg transfer; STAT5 phosphorylation assays; flow cytometry Cell reports High 40570369
2020 Nicotine increases miR-629-5p expression in CD8+ T cells, which directly targets IL2RB mRNA, suppressing IL-2Rβ (CD122) expression and downstream granzyme B production, thereby exhausting CD8+ T cell cytotoxic function; miR-629-5p mimic transfection reduced both IL2RB and GZMB levels, and this was recapitulated in humanized tumor xenografts. RNAseq and small RNAseq; miR-629-5p mimic transfection; luciferase reporter/target validation; nuclear imaging of granzyme B; humanized tumor xenograft Cancer immunology, immunotherapy : CII Medium 33146402
2025 IL-27 promotes Treg cell expression of CD122, and IL-27R-deficient Tregs are at a competitive disadvantage during homeostasis associated with reduced CD122 expression; CD122 blockade caused similar loss of Treg cells, and IL-27 improved Treg responsiveness to IL-2/IL-15 via upregulation of CD122. Mixed IL-27R-sufficient/deficient Treg chimeric mice; aging experiments tracking Treg erosion; CD122 blockade in vivo; in vitro IL-27 stimulation and CD122 expression assays Proceedings of the National Academy of Sciences of the United States of America Medium 41364763
2020 Chronic circadian disruption (shift-lag) reduces Eomes transcription factor expression in NK cells, which inhibits transcription of CD122 (IL2RB), leading to decreased NK cell cytolytic activity and impaired clearance of MHC-I-deficient tumor cells in vivo. Light-dark reversal circadian disruption mouse model; flow cytometry; in vivo tumor clearance assay; mRNA expression analysis Journal of cellular and molecular medicine Low 33185980
2020 IL-2Rβ (CD122) signaling in CD8+ T cells in Peyer's Patches mediates acute B cell apoptosis; CD122-targeted IL-2 complexes caused selective contraction of B cell subsets in Peyer's Patches (but not lamina propria or intraepithelial lymphocytes) via apoptosis. In vivo IL-2/anti-IL-2 antibody complexes targeting CD122; flow cytometry of gut compartments; apoptosis assays Scientific reports Medium 32728053
2024 IL2RB activates the JAK1/STAT5 signaling pathway in esophageal squamous cell carcinoma cells; IL2RB knockdown inhibited tumor cell proliferation, migration, invasion, and epithelial-mesenchymal transition, and was associated with CD8+ T cell depletion in the tumor microenvironment. Gain- and loss-of-function (knockdown/overexpression) in cell lines; in vivo tumor models; western blotting for JAK1/STAT5 pathway Annals of clinical and laboratory science Medium 40750242
2020 IL2RB (IL-2Rβ) transfection into peripheral blood mononuclear cells from septic patients elevated IFN-γ and IL-12 levels (Th1 cytokines) while reducing IL-4, IL-10, and IL-17A, demonstrating that IL2RB expression modulates Th1/Th2 balance and suppresses Th17 activation. PBMC transfection with IL2RB expression construct; ELISA for cytokine levels; bioinformatics dataset analysis Allergologia et immunopathologia Low 37169553

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis. The Journal of experimental medicine 232 15520244
2005 Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells. Journal of immunology (Baltimore, Md. : 1950) 224 16301610
2008 Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950) 127 18178821
2005 Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells. Blood 117 15878972
2010 Cutting edge: programmed death-1 defines CD8+CD122+ T cells as regulatory versus memory T cells. Journal of immunology (Baltimore, Md. : 1950) 108 20548035
2010 CD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis. Journal of immunology (Baltimore, Md. : 1950) 82 21098236
2013 Natural CD8+CD122+ T cells are more potent in suppression of allograft rejection than CD4+CD25+ regulatory T cells. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 81 24219162
2008 CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells. International immunology 79 18495626
2009 Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg. European journal of immunology 77 19609979
2019 A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. The Journal of experimental medicine 74 31040184
2007 Runx proteins are involved in regulation of CD122, Ly49 family and IFN-gamma expression during NK cell differentiation. International immunology 71 18003603
2016 CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America 69 26869716
2011 Antitumor immunity produced by the liver Kupffer cells, NK cells, NKT cells, and CD8 CD122 T cells. Clinical & developmental immunology 63 22190974
2007 CD8+CD122+ T cells, a newly identified regulatory T subset, negatively regulate Graves' hyperthyroidism in a murine model. Endocrinology 62 17823258
2011 The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development. Journal of immunology (Baltimore, Md. : 1950) 58 21984699
2017 IL-1β and IL-23 Promote Extrathymic Commitment of CD27+CD122- γδ T Cells to γδT17 Cells. Journal of immunology (Baltimore, Md. : 1950) 56 28855314
2015 CD8(+)CD122(+) T-Cells: A Newly Emerging Regulator with Central Memory Cell Phenotypes. Frontiers in immunology 54 26539191
2014 Regulatory CD8(+)CD122 (+) T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells. Metabolic brain disease 49 25537181
2018 CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection. The Journal of clinical investigation 47 30222140
2014 A naturally occurring CD8(+)CD122(+) T-cell subset as a memory-like Treg family. Cellular & molecular immunology 45 24793406
2010 Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk. European journal of human genetics : EJHG 45 20179739
2003 Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells. Experimental hematology 44 12829032
2014 IL-15-dependent CD8+ CD122+ T cells ameliorate experimental autoimmune encephalomyelitis by modulating IL-17 production by CD4+ T cells. European journal of immunology 40 25142300
2000 Mouse CD8+ CD122+ T cells with intermediate TCR increasing with age provide a source of early IFN-gamma production. Journal of immunology (Baltimore, Md. : 1950) 38 10820240
2017 A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection. Frontiers in immunology 33 29167674
2006 Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals. Journal of immunology (Baltimore, Md. : 1950) 33 16920913
2020 CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade. Cancer research 31 32948605
2004 Essential role of bystander cytotoxic CD122+CD8+ T cells for the antitumor immunity induced in the liver of mice by alpha-galactosylceramide. Journal of immunology (Baltimore, Md. : 1950) 31 15153469
2020 Chronic shift-lag promotes NK cell ageing and impairs immunosurveillance in mice by decreasing the expression of CD122. Journal of cellular and molecular medicine 30 33185980
2010 CD122+CD8+ Treg suppress vaccine-induced antitumor immune responses in lymphodepleted mice. European journal of immunology 30 20186876
2008 Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Immunology 29 18205792
2001 Functional IL-2 receptor beta (CD122) and gamma (CD132) chains are expressed by fibroblast-like synoviocytes: activation by IL-2 stimulates monocyte chemoattractant protein-1 production. Journal of immunology (Baltimore, Md. : 1950) 29 11238664
2022 Combining bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) improves systemic antitumor CD8+ T cell cytotoxicity over BEMPEG+RT. Journal for immunotherapy of cancer 24 35444059
2017 Suppression of allograft rejection by CD8+CD122+PD-1+ Tregs is dictated by their Fas ligand-initiated killing of effector T cells versus Fas-mediated own apoptosis. Oncotarget 24 28445940
1996 Regulated expression and function of CD122 (interleukin-2/interleukin-15R-beta) during lymphoid development. Blood 23 8547641
2018 IL-10 producing CD8+ CD122+ PD-1+ regulatory T cells are expanded by dendritic cells silenced for Allograft Inflammatory Factor-1. Journal of leukocyte biology 22 30512224
2013 The Rag2⁻Il2rb⁻Dmd⁻ mouse: a novel dystrophic and immunodeficient model to assess innovating therapeutic strategies for muscular dystrophies. Molecular therapy : the journal of the American Society of Gene Therapy 21 23975040
2023 Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice. Nature communications 20 37045833
2021 CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδ T cell activation. Journal for immunotherapy of cancer 20 33849925
2019 CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival. Frontiers in immunology 20 30863408
2019 Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk. International immunopharmacology 20 31279323
2021 Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer. NAR genomics and bioinformatics 19 33928242
2019 IL2RB maintains immune harmony. The Journal of experimental medicine 18 31068380
2017 c-REL and IκBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors. Journal of immunology (Baltimore, Md. : 1950) 16 28652399
2014 CD8+ CD122+ PD-1- effector cells promote the development of diabetes in NOD mice. Journal of leukocyte biology 16 25387835
2013 Association of IL-2RA and IL-2RB genes with erosive status in early rheumatoid arthritis patients (ESPOIR and RMP cohorts). Joint bone spine 16 24200909
2020 Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression. Cancer immunology, immunotherapy : CII 15 33146402
2019 Association between ADRB2, IL33, and IL2RB gene polymorphisms and lung cancer risk in a Chinese Han population. International immunopharmacology 15 31685439
2014 Genetic polymorphisms in IL-2, IL-10, TGF-β1, and IL-2RB and acute rejection in renal transplant patients. Clinical transplantation 15 24579958
2016 CXCR3 May Help Regulate the Inflammatory Response in Acute Lung Injury via a Pathway Modulated by IL-10 Secreted by CD8 + CD122+ Regulatory T Cells. Inflammation 14 26475448
2024 CXCL9, IL2RB, and SPP1, potential diagnostic biomarkers in the co-morbidity pattern of atherosclerosis and non-alcoholic steatohepatitis. Scientific reports 13 39013959
2019 Single nucleotide polymorphisms of the genes IL-2, IL-2RB, and JAK3 in patients with cutaneous leishmaniasis caused by Leishmania (V.) guyanensis in Manaus, Amazonas, Brazil. PloS one 13 31393896
2017 Chinese medicine Ginseng and Astragalus granules ameliorate autoimmune diabetes by upregulating both CD4+FoxP3+ and CD8+CD122+PD1+ regulatory T cells. Oncotarget 13 28947964
2024 Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity. Signal transduction and targeted therapy 12 38918390
2024 Astragalus polysaccharide enhances antitumoral effects of chimeric antigen receptor- engineered (CAR) T cells by increasing CD122+CXCR3+PD-1- memory T cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 12 39243425
2021 Human CD8 T-stem cell memory subsets phenotypic and functional characterization are defined by expression of CD122 or CXCR3. European journal of immunology 12 33844287
2020 The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells. Journal of immunology (Baltimore, Md. : 1950) 12 32393513
2017 Targeting of CD122 enhances antitumor immunity by altering the tumor immune environment. Oncotarget 12 29312597
2012 Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rγnull mice is attributed to a lack of CD11c+B220+CD122+ cells. Journal of immunology (Baltimore, Md. : 1950) 12 23018460
2011 Impact of IL2 and IL2RB genetic polymorphisms in kidney transplantation. Transplantation proceedings 12 21839273
2021 Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung Injury by Targeting IL2RB. BioMed research international 11 33954185
2018 Herbal Components of a Novel Formula PSORI-CM02 Interdependently Suppress Allograft Rejection and Induce CD8+CD122+PD-1+ Regulatory T Cells. Frontiers in pharmacology 11 29483872
2013 CD8+ CD122+ regulatory T cells contain clonally expanded cells with identical CDR3 sequences of the T-cell receptor β-chain. Immunology 11 23317140
1997 No evidence for a schizophrenia susceptibility gene in the vicinity of IL2RB on chromosome 22. American journal of medical genetics 11 9259369
2023 Combination of cancer vaccine with CD122-biased IL-2/anti-IL-2 Ab complex shapes the stem-like effector NK and CD8+ T cells against tumor. Journal for immunotherapy of cancer 10 37400134
2023 Exosomes containing miR-1469 regulate natural killer cells by targeting CD122 in non-segmental vitiligo. Journal of dermatological science 10 38307771
1994 12-Deoxyphorbol-13-O-phenylacetate 20 acetate [an agonist of protein kinase C beta 1 (PKC beta 1)] induces DNA synthesis, interleukin-2 (IL-2) production, IL-2 receptor alpha-chain (CD25) and beta-chain (CD122) expression, and translocation of PKC beta isozyme in human peripheral blood lymphocytes: evidence for a role of PKC beta 1 in human T cell activation. Journal of clinical immunology 10 7929699
2021 Role of IL-9, IL-2RA, and IL-2RB genetic polymorphisms in coronary heart disease. Herz 9 33651164
2021 TREM2 promotes natural killer cell development in CD3-CD122+NK1.1+ pNK cells. BMC immunology 9 33980160
2018 Decreased CD122 on CD56dim NK associated with its impairment in asymptomatic chronic HBV carriers with high levels of HBV DNA, HBsAg and HBeAg. Life sciences 9 29307521
2018 Association of genetic variations in PTPN2 and CD122 with ocular Behcet's disease. The British journal of ophthalmology 9 29502070
2011 Continuous activation of the CD122/STAT-5 signaling pathway during selection of antigen-specific regulatory T cells in the murine thymus. PloS one 9 21541329
2010 Roles of CD122+ cells in resistance against Neospora caninum infection in a murine model. The Journal of veterinary medical science 9 20460838
2024 CSF1R blockade slows progression of cerebral hemorrhage by reducing microglial proliferation and increasing infiltration of CD8 + CD122+ T cells into the brain. International immunopharmacology 8 38636374
2023 Anti-CD122 antibody restores specific CD8+ T cell response in nonalcoholic steatohepatitis and prevents hepatocellular carcinoma growth. Oncoimmunology 8 36891258
2022 Upregulated Expression of IL2RB Causes Disorder of Immune Microenvironment in Patients with Kawasaki Disease. BioMed research international 8 35924269
2017 Changes and clinical significance of CD8+CD122+ T cells in the peripheral blood of patients with ankylosing spondylitis. Clinical rheumatology 8 29110110
2025 Targeting the IL-15/CD122 signaling pathway: reversing TRM cell-mediated immune memory in vitiligo. Frontiers in immunology 7 40791580
2023 IL2RB affects Th1/Th2 and Th17 responses of peripheral blood mononuclear cells from septic patients. Allergologia et immunopathologia 7 37169553
2021 Impact of genetic variants in IL-2RA and IL-2RB on breast cancer risk in Chinese Han women. Biochemical genetics 7 33507447
2021 The Timing and Abundance of IL-2Rβ (CD122) Expression Control Thymic iNKT Cell Generation and NKT1 Subset Differentiation. Frontiers in immunology 7 34054809
2019 Genetic analysis of the relation between IL2RA/IL2RB and rheumatoid arthritis risk. Molecular genetics & genomic medicine 7 31134763
2018 Association of the TNF-α, IL-2, and IL-2RB gene variants with susceptibility to psoriasis in a Turkish cohort. Central-European journal of immunology 7 29736146
2024 A miRNA-7704/IL2RB/AKT feedback loop regulates tumorigenesis and chemoresistance in ovarian cancer. Experimental cell research 5 38565343
2021 CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation. Oncoimmunology 5 34858732
2025 Core fucosylation of IL-2RB is required for natural killer cell homeostasis. Cell reports 4 40753573
2024 Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing immunotherapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 4 39522264
2024 Human placental mesenchymal stromal cells promote the formation of CD8+CD122+PD-1+Tregs via CD73/Foxo1 to alleviate liver injury in graft-versus-host disease mice. International immunopharmacology 3 38968861
2020 CD122-targetted IL-2 signals cause acute and selective apoptosis of B cells in Peyer's Patches. Scientific reports 3 32728053
2020 Novel WT1 Target Genes: IL-2, IL-2RB, and IL-2RG Discovered during WT1 Silencing Using Lentiviral-Based RNAi in Myeloid Leukemia Cells. BioMed research international 3 33110919
2016 Donor-antigen Inoculation in the Testis Promotes Skin Allograft Acceptance Induced by Conventional Costimulatory Blockade via Induction of CD8 + CD122+ and CD4 + CD25+ Regulatory T Cells. Transplantation 3 26569069
1996 Quantitation of IL-2Rp75 (CD122) expression on mononuclear cells in rheumatic disease. Annals of the rheumatic diseases 3 8976644
2020 CD8+CD122+ T cell homeostasis is controlled by different levels of IL-15 trans-presentation. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2 32616380
2020 Corrigendum: A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection. Frontiers in immunology 2 32765495
2025 A dual-mode nanoplatform based on Cu2O@Au-Pt nanoenzyme and CHA-HCR DNA framework circuit for sensitive detection of CD122 and CD17. International journal of biological macromolecules 1 40185434
2025 A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency. Cell reports 1 40570369
2025 IL2RB Remodels the Immune Microenvironment and Promotes the Progression of Esophageal Squamous Cell Carcinoma. Annals of clinical and laboratory science 1 40750242
2024 CD122 is an activation marker ensuring proper proliferation of T cells in teleost. Fish & shellfish immunology 1 39153581
2025 IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis. Proceedings of the National Academy of Sciences of the United States of America 0 41364763
2023 Blockade of CD122 on memory T cells in the skin suppresses sclerodermatous graft-versus-host disease. Journal of dermatological science 0 36966029

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