Affinage

IL17F

Interleukin-17F · UniProt Q96PD4

Length
163 aa
Mass
18.0 kDa
Annotated
2026-04-28
100 papers in source corpus 24 papers cited in narrative 24 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IL-17F is a pro-inflammatory cytokine of the IL-17 family, produced primarily by Th17 cells, γδ T cells, and macrophages, that drives neutrophilic inflammation, antimicrobial defense, and tissue remodeling through signaling pathways distinct from yet overlapping with those of the closely related IL-17A. IL-17F signals as a homodimer or IL-17A/F heterodimer through an IL-17RA/IL-17RC receptor complex—with a structurally defined 2:1 IL-17RC:IL-17F stoichiometry that also permits IL-17RA-independent signaling—engaging the adaptor Act1 and TRAF6 to activate NF-κB (via TAK1–p65) and MAPK (MEK–ERK–MSK1–CREB) cascades, thereby inducing IL-6, IL-8, CCL20, IL-11, and antimicrobial peptides in epithelial cells, fibroblasts, smooth muscle cells, and macrophages (PMID:11591768, PMID:18411338, PMID:32187518, PMID:28474507, PMID:19251839, PMID:27576147). Transcription of IL17F in Th17 cells requires a CNS2 cis-regulatory element that recruits p300 and JMJD3 for chromatin remodeling, and is differentially regulated from IL-17A by STAT5/IL-2 signaling, which suppresses IL-17F while promoting IL-17A (PMID:22244845, PMID:37244461). In vivo, IL-17F has non-redundant roles from IL-17A: it mediates airway neutrophilia in steroid-insensitive asthma, drives colitis through antimicrobial protein–microbiota interactions that suppress Treg-inducing Clostridium species, promotes renal injury via CXCL1/CXCL5-dependent neutrophil recruitment, and stimulates osteoblast differentiation through Runx2/C/EBPβ independently of canonical Wnt signaling (PMID:30655284, PMID:29915298, PMID:27030744, PMID:30010083).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2001 High

    The initial cloning of IL-17F (ML-1) established it as a novel T cell–derived cytokine capable of inducing IL-6, IL-8, and ICAM-1 in epithelial cells, and receptor-blocking experiments indicated it signals through a receptor distinct from IL-17A's.

    Evidence Gene cloning, COS-7 transfection, ELISA, and anti-IL-17 blocking in bronchial epithelial cells

    PMID:11591768

    Open questions at the time
    • Receptor identity unknown at this stage
    • Intracellular signaling cascade not mapped
    • In vivo function not tested
  2. 2008 High

    Genetic knockout studies resolved a key question about whether IL-17F and IL-17A are functionally redundant, revealing distinct and sometimes opposing roles: IL-17F-deficient mice showed defective airway neutrophilia but protection from colitis, whereas IL-17A-deficient mice showed the opposite pattern; signaling was shown to require IL-17RA, Act1, and TRAF6.

    Evidence IL-17F and IL-17A KO mice in allergen challenge and colitis models, in vitro signaling assays

    PMID:18411338

    Open questions at the time
    • Molecular basis for opposing in vivo roles unclear
    • Receptor complex composition not fully defined
    • Act1/TRAF6 downstream branching pathways not dissected
  3. 2008 High

    Mapping of the MEK–ERK signaling arm downstream of IL-17F established that IL-17F induces IL-8 through ERK1/2 phosphorylation in keratinocytes, with in vivo confirmation showing ERK-dependent neutrophil recruitment in skin.

    Evidence Kinase inhibitors in keratinocytes, intradermal injection in mice, anti-IL-8 blocking

    PMID:18830271

    Open questions at the time
    • Transcription factor targets downstream of ERK not identified
    • Relative contribution of MAPK vs NF-κB arms unclear
  4. 2009 High

    The full receptor complex (IL-17RA/IL-17RC) and the ability of IL-17F to form both homodimers and IL-17A/F heterodimers were consolidated, defining the ligand–receptor system.

    Evidence Synthesis of receptor binding studies and cytokine secretion assays

    PMID:19233684

    Open questions at the time
    • Structural basis of receptor–ligand interaction unknown
    • Stoichiometry of receptor complex not determined
  5. 2009 High

    Extension of the MAPK signaling cascade revealed that IL-17F induces IL-11 through a Raf1–MEK1/2–ERK1/2–MSK1–CREB pathway in bronchial epithelial cells, identifying MSK1 as a critical kinase node.

    Evidence siRNA knockdown of MSK1/CREB combined with kinase inhibitors in bronchial epithelial cells

    PMID:19251839

    Open questions at the time
    • Whether MSK1–CREB axis is shared with IL-17A signaling unknown
    • Upstream selectivity for Raf1 isoform not tested
  6. 2012 High

    Identification of the CNS2 cis-regulatory element resolved how IL-17F transcription is selectively activated in Th17 cells: CNS2 contacts both Il17a and Il17f promoters and recruits the histone acetyltransferase p300 and demethylase JMJD3 to remodel chromatin, with CNS2 deletion impairing RORγt-driven expression.

    Evidence Targeted CNS2 deletion, ChIP, in vitro Th17 differentiation, EAE model

    PMID:22244845

    Open questions at the time
    • Whether CNS2 differentially regulates IL-17A vs IL-17F not resolved
    • Upstream signals targeting p300/JMJD3 to CNS2 not identified
  7. 2012 Medium

    A physiological role for IL-17F in bone biology was established: T lymphocyte–derived IL-17F stimulates osteoblast maturation, and lymphocyte-deficient Rag1−/− mice with impaired fracture healing had reduced IL-17F.

    Evidence Rag1−/− mouse fracture model, in vitro osteoblast stimulation

    PMID:22768215

    Open questions at the time
    • Direct IL-17F KO not used in fracture model
    • Downstream osteogenic signaling pathway not dissected
  8. 2016 High

    IL-17F was shown to drive renal injury in crescentic glomerulonephritis through CD4+ T cell–derived IL-17F inducing CXCL1/CXCL5 in kidney cells, recruiting neutrophils as the effector mechanism.

    Evidence IL-17F KO mice, neutralizing antibodies, adoptive transfer into Rag1−/− mice, neutrophil depletion

    PMID:27030744

    Open questions at the time
    • Specific kidney cell type responding to IL-17F not defined
    • Relative contribution of IL-17F vs IL-17A in chronic GN unclear
  9. 2017 High

    Two parallel signaling branches were fully delineated: IL-17F activates TAK1–NF-κB (p65) in airway smooth muscle cells to produce IL-6, and activates p38 MAPK/NF-κB to induce IκBζ in keratinocytes, which then controls psoriasis-associated gene expression (DEFB4, S100A7, CCL20).

    Evidence siRNA knockdown of TAK1 and IκBζ, pharmacological inhibitors, Western blot for phospho-p65 and p38, ELISA

    PMID:27576147 PMID:28474507

    Open questions at the time
    • Whether IκBζ is a universal mediator of IL-17F target genes outside keratinocytes unknown
    • TAK1 activation mechanism by Act1/TRAF6 not structurally resolved
  10. 2017 High

    Genetic epistasis using IL-17RA KO, IL-17F KO, and IL-17A KO mice demonstrated that IL-17F can signal through IL-17RC independently of IL-17RA, with this axis driving lower airway pathology in allergy and infection while mediating upper airway protection.

    Evidence Multiple KO mouse lines across Aspergillus, Pseudomonas, and Staphylococcus infection/allergy models

    PMID:28813677

    Open questions at the time
    • Signaling adaptors downstream of IL-17RC alone not identified
    • Basis for tissue-specific protective vs pathogenic outcomes unclear
  11. 2018 High

    A microbiome-dependent mechanism was uncovered for IL-17F in colitis: IL-17F promotes antimicrobial protein expression that suppresses Treg-inducing Clostridium cluster XIVa; loss of IL-17F expands these bacteria and intestinal Tregs, conferring protection.

    Evidence IL-17F and IL-17A KO mice, T cell transfer colitis in Rag2−/− mice, anti-IL-17F antibody, microbiome analysis

    PMID:29915298

    Open questions at the time
    • Specific antimicrobial proteins mediating effect not identified
    • Whether human microbiome responds similarly unknown
  12. 2018 Medium

    The osteogenic signaling pathway was mechanistically resolved: IL-17F activates Runx2 and C/EBPβ via IL-17RA/IL-17RC while promoting β-catenin degradation, establishing a Wnt-independent osteoblast differentiation pathway.

    Evidence siRNA knockdown of IL-17Ra/IL-17Rc in MC3T3-E1 cells, Western blot for signaling proteins

    PMID:30010083

    Open questions at the time
    • Mechanism of β-catenin degradation not determined
    • Single cell line limits generalizability
  13. 2019 High

    Reciprocal antibody blockade in steroid-insensitive asthma definitively separated IL-17F from IL-17A functions: anti-IL-17F ameliorated airway neutrophilia and hyperresponsiveness, while anti-IL-17A worsened eosinophilic inflammation.

    Evidence TDI-induced asthma mouse model, anti-IL-17F and anti-IL-17A mAbs, recombinant cytokine controls

    PMID:30655284

    Open questions at the time
    • Mechanism by which IL-17A blockade worsens eosinophilia unclear
    • Downstream effectors distinguishing neutrophilic vs eosinophilic pathways not identified
  14. 2020 High

    The structural basis of IL-17F receptor engagement was solved: crystal structure revealed a symmetric 2:1 IL-17RC:IL-17F complex where two IL-17RC molecules bind one IL-17F dimer, competing with IL-17RA and providing a structural rationale for IL-17RA-independent signaling.

    Evidence X-ray crystallography and biophysical binding assays

    PMID:32187518

    Open questions at the time
    • Full ternary complex with IL-17RA not structurally resolved
    • How 2:1 vs 1:1:1 stoichiometry triggers different downstream signals unknown
  15. 2023 High

    Differential transcriptional regulation of IL-17F vs IL-17A was resolved at the epigenomic level: STAT5/IL-2 signaling suppresses IL-17F while promoting IL-17A, and the two cytokines are predominantly expressed in distinct T cell populations within psoriatic lesions.

    Evidence Single-cell RNA-seq, ChIP-seq, cytokine-capture assay in psoriatic skin and in vitro systems

    PMID:37244461

    Open questions at the time
    • Transcription factors directly binding IL17F promoter vs CNS2 downstream of STAT5 not identified
    • Whether distinct T cell populations reflect stable lineage commitment or plasticity unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the full signaling cascade downstream of IL-17RC alone (without IL-17RA), the specific antimicrobial proteins through which IL-17F shapes the intestinal microbiome, and the structural basis of the complete ternary IL-17F/IL-17RA/IL-17RC signaling complex.
  • No structure of ternary IL-17F/IL-17RA/IL-17RC complex
  • Antimicrobial effectors downstream of IL-17F in gut not identified
  • IL-17RA-independent signaling adaptors unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 8
Localization
GO:0005576 extracellular region 2
Pathway
R-HSA-168256 Immune System 7 R-HSA-162582 Signal Transduction 5 R-HSA-1266738 Developmental Biology 3
Partners
IL17AIL17RAIL17RCTAK1TRAF3IP2TRAF6
Complex memberships
IL-17A/F heterodimerIL-17F homodimer

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 IL-17F regulates proinflammatory gene expression and requires IL-17 receptor A (IL-17RA), TRAF6, and Act1 for signaling, similar to IL-17A. In vivo, IL-17F-deficient mice showed defective airway neutrophilia in allergen challenge and reduced colitis severity, while IL-17A-deficient mice showed opposite effects, demonstrating distinct non-redundant roles. Genetic loss-of-function (IL-17F and IL-17A knockout mice), in vitro signaling assays, in vivo allergen challenge and colitis models The Journal of experimental medicine High 18411338
2009 IL-17F utilizes IL-17RA and IL-17RC as its receptor complex and employs Act1 and TRAF6 as signal transducers to induce expression of pro-inflammatory cytokines and chemokines in multiple cell types. IL-17F can be secreted as homodimers or as heterodimers with IL-17A. Review synthesizing receptor binding studies, signaling pathway analyses, and cytokine secretion assays Cytokine High 19233684
2020 Crystal structure of extracellular domain of human IL-17RC in complex with IL-17F revealed that IL-17RC forms a symmetrical 2:1 complex with IL-17F (two receptor molecules per cytokine dimer), competing with IL-17RA for cytokine binding. IL-17A and IL-17A/F heterodimers also form 2:1 complexes with IL-17RC, suggesting IL-17RA-independent IL-17F signaling pathways. X-ray crystallography, biophysical binding assays Immunity High 32187518
2012 A conserved noncoding sequence 2 (CNS2) element physically interacts with both Il17 and Il17f gene promoters and is necessary and sufficient for their selective transcription in Th17 cells. CNS2-mediated recruitment of histone-modifying enzymes p300 and JMJD3 drives chromatin remodeling at the Il17-Il17f locus, and targeted deletion of CNS2 impairs RORγt-driven IL-17 and IL-17F expression. Targeted deletion of cis-regulatory element, chromatin immunoprecipitation, in vitro Th17 differentiation, EAE model Immunity High 22244845
2008 IL-17F induces IL-8 production in normal human epidermal keratinocytes via ERK1/2 phosphorylation (MEK-ERK pathway). Intradermal injection of IL-17F in mouse skin induced IL-8 mRNA expression and ERK1/2 phosphorylation, causing marked neutrophil infiltration that was blocked by anti-IL-8 antibody. In vitro keratinocyte stimulation with kinase inhibitors, in vivo intradermal injection, ELISA, real-time PCR, histology, immunohistochemistry The Journal of investigative dermatology High 18830271
2009 IL-17F induces IL-11 expression in bronchial epithelial cells through the Raf1-MEK1/2-ERK1/2-MSK1-CREB signaling pathway. siRNA knockdown of MSK1 inhibited CREB activation and IL-11 expression, and siRNAs targeting both MSK1 and CREB blocked IL-17F-induced IL-11 production. siRNA knockdown, kinase inhibitors, phosphorylation assays (Western blot), ELISA, real-time PCR American journal of physiology. Lung cellular and molecular physiology High 19251839
2017 IL-17F stimulation induces IκBζ expression in human keratinocytes via p38 MAPK and NF-κB signaling pathways. IκBζ in turn acts as a key regulator of IL-17F-inducible psoriasis-associated genes including DEFB4/hBD2, S100A7, CCL20, IL-8, and CHI3L1, as demonstrated by siRNA silencing of IκBζ. siRNA knockdown of IκBζ, pharmacological inhibitors of p38 MAPK and NF-κB, real-time PCR, Western blot Experimental dermatology High 27576147
2017 IL-17F induces IL-6 production in airway smooth muscle cells (ASMCs) via the TAK1-NF-κB signaling pathway. siRNA knockdown of TAK1 abolished IL-17F-induced phosphorylation of NF-κB p65, and pharmacological inhibition of either TAK1 or NF-κB blocked IL-6 production. siRNA knockdown, pharmacological inhibitors (5Z-7-oxozeaenol, BAY 11-7082), Western blot for phosphorylation, ELISA, real-time PCR Immunity, inflammation and disease High 28474507
2001 IL-17F (initially named ML-1) is a novel cytokine expressed in activated CD4+ T cells, basophils, and mast cells that induces IL-6, IL-8, and ICAM-1 expression in primary bronchial epithelial cells. The ICAM-1 induction effect was not blocked by saturating IL-17, suggesting IL-17F signals through a distinct receptor. Gene cloning from human cDNA, transient transfection of COS-7 cells, ELISA, flow cytometry for ICAM-1, antibody blocking assays Journal of immunology High 11591768
2010 IL-17F induces IL-6 production in normal human epidermal keratinocytes (NHEKs) in a time-dependent manner, an effect blocked by a chimeric IL-17 receptor inhibitor. Intradermal injection of IL-17F in mouse skin upregulated IL-6 mRNA 3.2-fold. IL-6 induction by IL-17F was higher than that induced by TNF-α or IL-17A. In vitro keratinocyte stimulation, ELISA, real-time PCR, in vivo intradermal injection in mice, immunohistochemistry Archives of dermatological research Medium 20148256
2018 IL-17F promotes osteoblast differentiation through a mechanism involving IL-17RA/IL-17RC receptor signaling that activates Runx2 and C/EBP-β while causing β-catenin degradation, acting independently of canonical Wnt signaling. siRNA knockdown of IL-17Ra and IL-17Rc decreased expression of Act2, Runx2, and C/EBP-β. siRNA knockdown of IL-17Ra and IL-17Rc, Western blot for signaling proteins, gene expression analysis in MC3T3-E1 cells Bone Medium 30010083
2012 T-lymphocytes produce IL-17F to stimulate osteoblast maturation during the early phase of fracture repair. In vitro studies showed IL-17F alone stimulates osteoblast maturation, and Rag1-/- mice (lacking lymphocytes) showed impaired fracture healing associated with IL-17F deficiency. Rag1-/- mouse model, in vitro osteoblast stimulation, histology, µCT, biomechanical testing, quantitative gene expression PloS one Medium 22768215
2018 IL-17F suppression but not IL-17A suppression protects against colitis by inducing regulatory T cells through modification of intestinal microbiota. IL-17F drives expression of antimicrobial proteins that normally suppress Clostridium cluster XIVa (Treg-inducing bacteria); loss of IL-17F increases this Clostridium cluster and expands intestinal Tregs. IL-17F and IL-17A knockout mice, T cell transfer colitis model in Rag2-/- mice, anti-IL-17F and anti-IL-17A antibody treatment, microbiome analysis, Treg quantification Nature immunology High 29915298
2016 IL-17F-deficient mice are protected from tissue injury in acute crescentic glomerulonephritis (GN). CD4+ T cell-derived IL-17F drives renal neutrophil infiltration by inducing expression of CXCL1 and CXCL5 in kidney cells. Neutrophil depletion abolished the difference between IL-17F-deficient and wild-type nephritic mice. IL-17F knockout mice, neutralizing antibodies, adoptive transfer into Rag1-/- mice, neutrophil depletion, cytokine induction assays in kidney cells Journal of the American Society of Nephrology High 27030744
2017 The IL-17F/IL-17RC signaling axis (independent of IL-17RA) promotes respiratory allergy and exacerbates lower airway inflammation by Aspergillus or Pseudomonas infection, while in upper airway Staphylococcus aureus infection the same axis mediates protection. Mice lacking IL-17RA but retaining IL-17RC showed exacerbated lower airway pathology driven by IL-17F. IL-17A KO, IL-17F KO, and IL-17RA KO mice in infection and allergy models; genetic epistasis between receptor and cytokine knockouts Cell reports High 28813677
2009 IL-17A controls IL-17F production via IL-17RA signaling; IL-17A-deficient mice showed elevated plasma IL-17F levels and splenocytes from these mice produced more IL-17F in response to IL-23. Adding recombinant IL-17A to IL-17A-deficient splenocyte cultures reduced IL-17F mRNA and protein, an effect absent in IL-17RA-deficient cells. IL-17A KO and IL-17RA KO mice, ex vivo splenocyte differentiation, cytokine measurement by ELISA and PCR, recombinant cytokine add-back Journal of immunology Medium 19542376
2011 IL-17F production by macrophages requires MyD88 adapter protein downstream of TLR4/LPS signaling. C5a amplifies IL-17F production via C5aR through PI3K-Akt pathway phosphorylation at threonine 308. Pharmacological inhibition of PI3K-Akt greatly reduced IL-17F production and mRNA. MyD88 knockout macrophages, pharmacological PI3K-Akt inhibitors, Western blot for Akt phosphorylation, ELISA, endotoxemia and CLP in vivo models FASEB journal High 21859896
2019 Fusobacterium nucleatum promotes intestinal inflammation in ulcerative colitis by targeting CARD3 through NOD2, which activates the IL-17F/NF-κB signaling pathway. Mechanistically, F. nucleatum infection upregulates CARD3 expression, which feeds into IL-17F-driven NF-κB activation. In vitro and in vivo F. nucleatum infection models, NF-κB pathway analysis, gene expression studies The Journal of pathology Medium 31610014
2019 IL-17F, rather than IL-17A, mediates airway inflammation and neutrophilia in a toluene diisocyanate (TDI)-induced steroid-insensitive asthma model. Anti-IL-17F ameliorated TDI-induced airway hyperresponsiveness and neutrophilia, while anti-IL-17A worsened airway eosinophil recruitment and mucus production. TDI-induced asthma mouse model, anti-IL-17F and anti-IL-17A monoclonal antibody blockade, recombinant cytokine administration, AHR measurement, differential cell counts The European respiratory journal High 30655284
2023 IL-17A and IL-17F expression occurs predominantly in distinct T cell populations in psoriatic disease. STAT5/IL-2 signaling exerts opposing effects on each gene: promoting IL-17A while suppressing IL-17F. The IL17A-F locus shows a broad H3K4me3 region, and higher IL17F expression is linked to greater cell proliferation. Single-cell RNA sequencing, chromatin immunoprecipitation sequencing, novel cytokine-capture technique combined with ChIP-seq and RNA-seq in lesional psoriatic skin and in vitro systems The Journal of allergy and clinical immunology High 37244461
2015 IL-17F induces autophagy in RAW 264.7 macrophages, promoting LC3B-II accumulation, increased autophagosome formation, and enhanced autophagic flux. IL-17F was considerably more efficient than IL-17A in promoting autophagy and significantly decreased intracellular counts of Mycobacterium terrae. LC3B-II Western blot, confocal microscopy for intracellular LC3B redistribution, acidic vesicular organelle staining, colony-forming unit assays Biomedicine & pharmacotherapy Medium 26796276
2020 IL-17F directly stimulates osteogenic differentiation of human periosteal cells, and T helper 17/γδ T cell supernatants also potently stimulate in vitro bone formation. Dual inhibition of IL-17A and IL-17F (bimekizumab) blocked osteogenic differentiation more deeply than either alone, potentially via increased expression of Wnt antagonist DKK1. Human periosteum-derived cell model of osteogenic differentiation, recombinant cytokines, T cell supernatants, AS patient serum, antibody blockade, DKK1 expression analysis RMD open Medium 32723833
2020 IL-17F and IL-17A act through macrophage orchestration (M2-like polarization) rather than directly on lung cancer cells to promote tumor growth, proliferation, and angiogenesis. Conditioned media from IL-17A/F-stimulated macrophages promoted lung cancer cell migration and in vivo tumor growth via enhanced M2 macrophage polarization. Flow cytometry for macrophage polarization, ELISA, SRB viability assay, CAM in vivo assay, conditioned media experiments Cellular oncology Medium 32227296
2015 IL-17F induces NF-κB phospho-p65 and ERK phosphorylation in human gingival fibroblasts, and promotes IL-6, CXCL8, and CCL20 production through IL-17 receptor signaling. siRNA knockdown of IL-17R reduced these inflammatory cytokine outputs. siRNA knockdown of IL-17R, Western blot for NF-κB and ERK phosphorylation, RT-PCR and ELISA for cytokine production Inflammation Medium 25384562

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Regulation of inflammatory responses by IL-17F. The Journal of experimental medicine 620 18411338
2008 IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. The Journal of clinical investigation 350 19075395
2008 Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD. Inflammatory bowel diseases 280 18088064
1997 Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn-Schmiedeberg's archives of pharmacology 274 9089668
2005 TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. The Journal of biological chemistry 201 16361256
2011 Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synoviocytes. Annals of the rheumatic diseases 159 21345813
2012 T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair. PloS one 141 22768215
2001 Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. Journal of immunology (Baltimore, Md. : 1950) 141 11591768
2009 IL-17F: regulation, signaling and function in inflammation. Cytokine 140 19233684
2018 Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota. Nature immunology 139 29915298
2016 Identification of IL-17F/frequent exacerbator endotype in asthma. The Journal of allergy and clinical immunology 127 27931975
2005 TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage. The Journal of biological chemistry 124 16257972
2012 Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2. Immunity 110 22244845
1999 Infrared spectroscopy of human tissue. V. Infrared spectroscopic studies of myeloid leukemia (ML-1) cells at different phases of the cell cycle. Biospectroscopy 110 10478952
1992 Induction by bufalin of differentiation of human leukemia cells HL60, U937, and ML1 toward macrophage/monocyte-like cells and its potent synergistic effect on the differentiation of human leukemia cells in combination with other inducers. Cancer research 108 1324788
2010 Identification of cells expressing IL-17A and IL-17F in the lungs of patients with COPD. Chest 105 20864612
2016 Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. PloS one 100 26895034
2008 TRP-ML1 functions as a lysosomal NAADP-sensitive Ca2+ release channel in coronary arterial myocytes. Journal of cellular and molecular medicine 83 18754814
2019 Fusobacterium nucleatum facilitates ulcerative colitis through activating IL-17F signaling to NF-κB via the upregulation of CARD3 expression. The Journal of pathology 82 31610014
2009 IL-17A controls IL-17F production and maintains blood neutrophil counts in mice. Journal of immunology (Baltimore, Md. : 1950) 81 19542376
2008 Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for mucolipidosis type IV pathogenesis. The Journal of experimental medicine 80 18504305
2010 Involvement of IL-17F via the induction of IL-6 in psoriasis. Archives of dermatological research 75 20148256
2023 The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases. Frontiers in immunology 73 37600764
2020 Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. Immunity 65 32187518
2008 Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis. The Journal of investigative dermatology 65 18830271
2015 Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma. Allergy 59 25394579
2015 Investigating the contribution of IL-17A and IL-17F to the host response during Escherichia coli mastitis. Veterinary research 59 26062913
2014 IL-17A, IL-17F and IL-23R Gene Polymorphisms in Polish Patients with Rheumatoid Arthritis. Archivum immunologiae et therapiae experimentalis 59 25387578
2015 MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells. Molecular and cellular endocrinology 53 25643979
2020 Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells. RMD open 47 32723833
2017 Ultra-Sensitive Measurement of IL-17A and IL-17F in Psoriasis Patient Serum and Skin. The AAPS journal 47 28534291
2016 IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases. Journal of the American Society of Nephrology : JASN 47 27030744
2008 Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells. Journal of cellular physiology 47 18270969
2005 Polymorphisms in the interleukin 17F gene (IL17F) and asthma. Genes and immunity 47 15703761
1999 A requirement for K+-channel activity in growth factor-mediated extracellular signal-regulated kinase activation in human myeloblastic leukemia ML-1 cells. Blood 47 10381506
2002 Ultraviolet-induced junD activation and apoptosis in myeloblastic leukemia ML-1 cells. The Journal of biological chemistry 46 12082101
2017 The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways. Cell reports 45 28813677
2016 Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: an updated meta-analysis. Scientific reports 45 26843459
2017 Robust immunosensing system based on biotin-streptavidin coupling for spatially localized femtogram mL-1 level detection of interleukin-6. Biosensors & bioelectronics 44 29127899
2012 The IL-17F sequence variant is associated with susceptibility to tuberculosis. Gene 44 23219503
1996 Induction of human myeloblastic ML-1 cell G1 arrest by suppression of K+ channel activity. The American journal of physiology 43 8997206
1993 Altered cytoplasmic/nuclear distribution of the c-myc protein in differentiating ML-1 human myeloid leukemia cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 43 8518229
2015 The polymorphism rs763780 in the IL-17F gene is associated with response to biological drugs in patients with psoriasis. Pharmacogenomics 42 26415694
2011 Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1(-/-) cells. American journal of physiology. Cell physiology 42 21613607
1994 Cell cycle arrest and protein kinase modulating effect of bufalin on human leukemia ML1 cells. Anticancer research 42 8074471
2014 Potential involvement of IL-17F in asthma. Journal of immunology research 41 24829928
2019 IL-17F, rather than IL-17A, underlies airway inflammation in a steroid-insensitive toluene diisocyanate-induced asthma model. The European respiratory journal 40 30655284
2012 Chicken IL-17F: identification and comparative expression analysis in Eimeria-infected chickens. Developmental and comparative immunology 39 22922588
2017 Association of IL17A and IL17F genes with rheumatoid arthritis disease and the impact of genetic polymorphisms on response to treatment. Immunology letters 37 28143790
2011 IL-17A and IL-17F expression in B lymphocytes. International archives of allergy and immunology 37 22123224
2020 IL-17A and IL-17F orchestrate macrophages to promote lung cancer. Cellular oncology (Dordrecht, Netherlands) 36 32227296
2014 Genetic variations of IL17F and IL23A show associations with Behçet's disease and Vogt-Koyanagi-Harada syndrome. Ophthalmology 36 25439430
2011 Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and АML1-ETO oncogenes. Cell cycle (Georgetown, Tex.) 36 22101339
2009 Cutting edge: an IL-17F-CreEYFP reporter mouse allows fate mapping of Th17 cells. Journal of immunology (Baltimore, Md. : 1950) 36 19155467
2012 Evaluation of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis. Human immunology 35 23137879
2019 Bimekizumab: The First Dual Inhibitor of Interleukin (IL)-17A and IL-17F for the Treatment of Psoriatic Disease and Ankylosing Spondylitis. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 34 31172372
1993 Alterations in a voltage-gated K+ current during the differentiation of ML-1 human myeloblastic leukemia cells. The Journal of membrane biology 34 8492309
2014 Significant association between IL23R and IL17F polymorphisms and clinical features of colorectal cancer. Immunology letters 33 24440568
2023 Differential regulation of IL-17A and IL-17F via STAT5 contributes to psoriatic disease. The Journal of allergy and clinical immunology 32 37244461
2017 IL-17F regulates psoriasis-associated genes through IκBζ. Experimental dermatology 32 27576147
2016 IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis. BMC musculoskeletal disorders 32 27169372
2015 IL-17A and IL-17F induce autophagy in RAW 264.7 macrophages. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 32 26796276
2009 IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway. American journal of physiology. Lung cellular and molecular physiology 32 19251839
2013 Regulatory effects of C5a on IL-17A, IL-17F, and IL-23. Frontiers in immunology 31 23316190
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