Affinage

IFNGR1

Interferon gamma receptor 1 · UniProt P15260

Length
489 aa
Mass
54.4 kDa
Annotated
2026-04-28
75 papers in source corpus 21 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IFNGR1 is the ligand-binding α-chain of the interferon-γ receptor that initiates JAK–STAT1 signaling to drive antimicrobial immunity, antigen presentation, and immune surveillance. Its cell-surface abundance is controlled at multiple levels: transcriptionally by an Egr3/Nab1 repressive complex induced by type I IFNs and by IFN-γ itself through chromatin remodeling at enhancer elements (PMID:23935197, PMID:31585982); and post-translationally by S-palmitoylation at Cys122, which triggers AP3D1-dependent lysosomal sorting, as well as by FBXW7- and RNF149-mediated ubiquitin–proteasome degradation, while TMEM199/CCDC115 promotes recycling through RAB11A-positive endosomes (PMID:33627378, PMID:32284542, PMID:38989590, PMID:41319859). Dominant-negative frameshift mutations (e.g., 818del4) that truncate the intracytoplasmic domain accumulate on the surface and competitively block signaling, causing Mendelian susceptibility to mycobacterial disease (PMID:10192386). Upon IFN-γ stimulation, IFNGR1 is endocytosed and translocated to the nucleus where it associates with STAT1α at GAS promoter elements and harbors a transactivation domain, indicating a direct transcriptional co-regulatory function (PMID:10888113, PMID:16785527).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1999 High

    Establishing that truncating IFNGR1 mutations cause disease through a dominant-negative mechanism answered why heterozygous patients were susceptible to mycobacteria: truncated receptors accumulate on the cell surface and competitively sequester IFN-γ from wild-type receptors.

    Evidence Genetic analysis and functional signaling assays in cells from 18 patients across 12 families

    PMID:10192386

    Open questions at the time
    • Precise recycling/internalization machinery governing wild-type vs. truncated receptor trafficking was unknown
    • Whether dominant-negative effect extends to all immune cell subsets was not tested
  2. 2000 Medium

    Discovery that IFNGR1 undergoes ligand-dependent nuclear translocation and associates with STAT1α challenged the view that IFNGR1 functions solely as a surface signaling scaffold.

    Evidence Immunofluorescence, co-immunoprecipitation, and subcellular fractionation in IFN-γ-stimulated WISH cells

    PMID:10888113

    Open questions at the time
    • Whether nuclear IFNGR1 directly contacts DNA was unresolved
    • Functional consequences of nuclear translocation were not demonstrated
    • Single cell line, single lab
  3. 2006 Medium

    Demonstrating that nuclear IFNGR1 binds GAS elements in IFN-γ-responsive promoters and harbors a transactivation domain established a direct transcriptional co-regulatory role, explaining the functional relevance of its nuclear translocation.

    Evidence ChIP-PCR, EMSA with GAS oligonucleotides, GAL4-IFNGR1 fusion transactivation assay in WISH cells

    PMID:16785527

    Open questions at the time
    • Genome-wide binding profile of nuclear IFNGR1 not determined
    • No structural basis for how IFNGR1 contacts DNA or transcriptional machinery
    • Single lab, single cell line
  4. 2006 Medium

    Identification of functionally distinct IFNGR1 promoter polymorphisms with cell-type-specific effects on transcription factor binding and expression revealed that IFNGR1 levels are subject to genetically encoded, lineage-specific transcriptional control.

    Evidence EMSA and promoter-reporter assays comparing alleles across B-lymphocytes, epithelial cells, and T-lymphocytes

    PMID:16600993 PMID:18593809

    Open questions at the time
    • Identity of the ~35 kDa B-cell nuclear factor not determined
    • In vivo relevance of polymorphism-driven expression differences not established
  5. 2013 High

    Elucidating how type I IFNs silence IFNGR1 transcription through an Egr3/Nab1 repressive complex explained the mechanistic basis of IFN cross-regulation: type I IFNs desensitize macrophages to IFN-γ by removing its receptor at the mRNA level.

    Evidence ChIP for RNA Pol II and acetylated histones, promoter mutagenesis, Nab1 siRNA knockdown in macrophages

    PMID:23935197

    Open questions at the time
    • Whether Egr3/Nab1 mechanism operates in non-macrophage lineages was not tested
    • Chromatin remodelers recruited by Nab1 were not identified
  6. 2013 High

    Cell-type-specific deletion of IFNGR1 in CD8α+ DCs established that IFNGR1 on this DC subset is essential for the initial IL-12 burst that restrains IL-4-driven myeloid polarization during Listeria infection, defining a non-redundant role for IFNGR1 in innate immune circuit wiring.

    Evidence Itgax-cre Ifngr1 floxed conditional knockout mice, Listeria infection model, IL-4 neutralization epistasis

    PMID:24048899

    Open questions at the time
    • Whether this DC-intrinsic role extends to other intracellular pathogens was not assessed
    • Downstream signaling events in DCs beyond IL-12 production were not mapped
  7. 2014 High

    Showing that IFNGR1 on extracellular vesicles carries IFN-γ and activates STAT1 in recipient cells uncovered a paracrine signaling mode that extends IFN-γ action beyond direct ligand–receptor encounter.

    Evidence Co-immunoprecipitation of IFN-γ/IFNGR1 on EVs, siRNA knockdown of STAT1 and IFNGR1 in target cells

    PMID:25242146

    Open questions at the time
    • Quantitative contribution of EV-borne vs. soluble IFN-γ signaling in vivo unknown
    • Sorting mechanism that loads IFNGR1 onto EVs not identified
  8. 2017 High

    In vivo transgenic rescue demonstrated that type I IFN-mediated IFNGR1 downregulation on macrophages is functionally immunosuppressive during Listeria infection, directly linking the Egr3/Nab1 transcriptional mechanism to impaired host defense.

    Evidence Transgenic macrophage-specific FLAG-IFNGR1 mice resistant to IFN-α/β-induced downregulation, Listeria infection model

    PMID:28542482

    Open questions at the time
    • Whether forced IFNGR1 expression on macrophages during viral infection would cause immunopathology was not addressed
  9. 2019 Medium

    Demonstrating that IFN-γ itself downregulates IFNGR1 transcription via chromatin remodeling at enhancer sites (not by receptor internalization) established a second, type I IFN-independent negative feedback loop that limits the duration of IFN-γ signaling.

    Evidence Flow cytometry, qRT-PCR, chromatin accessibility assays at ifngr1 enhancers in murine and human CD14+ cells

    PMID:31585982

    Open questions at the time
    • Identity of transcription factors mediating IFN-γ-driven enhancer remodeling not determined
    • Single lab
  10. 2020 High

    Identification of FBXW7 as an E3 ubiquitin ligase targeting IFNGR1 for proteasomal degradation revealed how ELF5 loss in triple-negative breast cancer stabilizes IFNGR1, activating tumor-intrinsic IFN-γ signaling that drives immunosuppressive PD-L1 expression and neutrophil recruitment.

    Evidence Co-immunoprecipitation, protein stability assays, FBXW7/ELF5 knockdown/overexpression, TNBC mouse models

    PMID:32284542

    Open questions at the time
    • FBXW7 degron motif on IFNGR1 not mapped
    • Whether FBXW7-mediated degradation operates in non-cancer cell types was not shown
  11. 2021 High

    Discovery that IFNGR1 is S-palmitoylated at Cys122 and that palmitoylated IFNGR1 is sorted to lysosomes by AP3D1 defined a lipid-modification-dependent quality control pathway; optineurin antagonizes this pathway to stabilize IFNGR1 and sustain IFN-γ signaling and antitumor immunity.

    Evidence Acyl-RAC palmitoylation assays, C122A mutagenesis, Co-IP of AP3D1/optineurin with IFNGR1, optineurin KO mice, pharmacological palmitoylation inhibition

    PMID:33627378

    Open questions at the time
    • Specific palmitoyltransferase(s) responsible for Cys122 modification in non-cancer contexts not definitively identified
    • Structural basis of optineurin–AP3D1 competition unknown
  12. 2021 Medium

    Demonstrating that paraspeckle components NEAT1_2 and NONO sequester IFNGR1 mRNA revealed a post-transcriptional layer of IFNGR1 regulation that tumors exploit for immune evasion.

    Evidence S1-aptamer RNA pulldown/mass spectrometry, RNA immunoprecipitation, NEAT1_2/NONO knockdown with T-cell cytolysis assays in HCC cells

    PMID:33667716

    Open questions at the time
    • Whether paraspeckle sequestration of IFNGR1 mRNA is specific or part of broader mRNA retention was not resolved
    • Single lab, single cancer type
  13. 2023 Medium

    Identification of ZDHHC3 as a palmitoyltransferase driving IFNGR1 lysosomal degradation during P. gingivalis infection extended the palmitoylation–lysosomal sorting mechanism to infection-driven contexts.

    Evidence Click-iT palmitoylation assay, C122A mutagenesis, LAMP2 colocalization, 2-BP inhibition in esophageal cancer cells

    PMID:37488798

    Open questions at the time
    • Whether ZDHHC3 is the relevant palmitoyltransferase in immune cells or only in this cancer model is unclear
    • Single lab
  14. 2024 High

    Identifying RNF149 as a STAT1-induced E3 ligase that degrades IFNGR1 completed a negative feedback circuit: IFN-γ activates STAT1, STAT1 induces RNF149, and RNF149 destroys IFNGR1 to limit further signaling, with in vivo relevance for cardiac macrophage inflammation after myocardial infarction.

    Evidence IP/mass spectrometry, RNF149 KO mice, bone marrow transplantation, adenoviral overexpression, IFNGR1 KO epistasis rescue

    PMID:38989590

    Open questions at the time
    • Ubiquitylation sites on IFNGR1 targeted by RNF149 not mapped
    • Whether RNF149 and FBXW7 act on IFNGR1 redundantly or in different contexts not determined
  15. 2025 Medium

    Discovery that TMEM199/CCDC115 interacts with IFNGR1 and recruits TRAPPII to activate RAB11A-mediated recycling defined a positive-regulatory trafficking route that sustains surface IFNGR1 and downstream PD-L1 expression.

    Evidence Co-immunoprecipitation, RAB11A recycling endosome colocalization, TRAPPII recruitment assay, PD-L1 expression readout

    PMID:41319859

    Open questions at the time
    • Whether TMEM199/CCDC115 recycling is constitutive or IFN-γ-stimulated is not clear
    • Single lab, mechanism of TRAPPII recruitment not structurally resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include the genome-wide binding targets and structural basis for nuclear IFNGR1's transcriptional role, how the multiple degradation pathways (FBXW7, RNF149, palmitoylation/AP3D1) are coordinated across cell types, and whether pharmacological stabilization of IFNGR1 can be harnessed to enhance antitumor immunity in vivo.
  • No structural model of IFNGR1 nuclear complex with STAT1 or GAS DNA
  • No systematic comparison of degradation pathway hierarchy across immune cell subsets
  • No clinical-grade IFNGR1-stabilizing therapeutic validated in vivo

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0140110 transcription regulator activity 1
Localization
GO:0005886 plasma membrane 5 GO:0005634 nucleus 2 GO:0005764 lysosome 2 GO:0005768 endosome 1 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-168256 Immune System 7 R-HSA-162582 Signal Transduction 6 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-392499 Metabolism of proteins 3 R-HSA-9609507 Protein localization 2
Partners
AP3D1CCDC115FBXW7IFNGR2OPTNRNF149STAT1TMEM199
Complex memberships
IFN-γ receptor complex (IFNGR1/IFNGR2)

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 IFNGR1 frameshift small deletions (818del4 and overlapping variants) produce truncated receptors that lack the intracytoplasmic domain; these accumulate on the cell surface due to impaired recycling, abrogate signaling, and exert a dominant-negative effect on wild-type IFNGR1 signaling by competing for IFN-γ binding while failing to transduce signal. Genetic analysis of patient cells, cell-surface expression assays, functional signaling assays (dominant-negative mechanism demonstrated in heterozygous patients) Nature genetics High 10192386
2000 Following IFN-γ stimulation, IFNGR1 (but not IFNGR2) is endocytosed and translocated to the nucleus in a ligand-dependent manner, where it co-localizes and co-immunoprecipitates with STAT1α during its nuclear accumulation, suggesting an active intracellular signaling role for IFNGR1 beyond the cell surface. Immunofluorescence, immunoprecipitation, subcellular fractionation in WISH cells treated with IFN-γ Journal of interferon & cytokine research Medium 10888113
2006 Nuclear IFNGR1 is recruited, together with IFN-γ and STAT1α, to the IFN-γ-activated sequence (GAS) element in the promoters of IFN-γ-activated genes; IFNGR1 fused to the yeast GAL4 DNA-binding domain drives transcription from a GAL4 response element, indicating IFNGR1 contains a transactivation domain. Chromatin immunoprecipitation (ChIP)-PCR, EMSA with biotinylated GAS oligonucleotide, GAL4-IFNGR1 fusion transactivation assay, GAS-luciferase reporter assay in WISH cells Journal of immunology Medium 16785527
2007 The novel dominant IFNGR1 mutation 774del4 (and the known 818del4) generates truncated IFNGR1 that accumulates on the cell surface due to impaired intracellular recycling/stability, thereby exerting a dominant-negative effect on IFN-γ/STAT1 signal transduction. Transient transfection of truncated IFNGR1 constructs in HEK293 cells, cell-surface IFNGR1 staining, STAT1 phosphorylation assay Journal of medical genetics Medium 17513528
2009 A germ-line mutation of the IFNGR1 translation initiation codon (M1K) abolishes detectable IFNGR1 expression in fibroblasts, but residual expression in EBV-transformed B cells arises from leaky translation initiation at non-AUG codons and the third AUG (position 19), producing normal-sized, functional IFNGR1 protein—establishing a cell-type-specific partial deficiency. Protein expression analysis in patient fibroblasts and EBV-B cells, mutational analysis, IFN-γ signaling functional assays Human molecular genetics Medium 19880857
2013 Type I IFN (IFN-β) treatment rapidly silences ifngr1 transcription in macrophages by inducing recruitment of an Egr3/Nab1 repressive complex to an Egr-binding site in the proximal ifngr1 promoter, reducing activated RNA Pol II and histone acetylation at the promoter; Nab1 knockdown prevents both IFNGR1 downregulation and loss of promoter histone acetylation. Actinomycin D comparison, ChIP for RNA Pol II and acetylated histones, IFNGR1-luciferase reporter with promoter mutations, siRNA knockdown of Nab1 in macrophage cell line Journal of immunology High 23935197
2013 Conditional loss of IFNGR1 specifically in CD8α+ dendritic cells (Itgax-cre+Ifngr1f/f mice) abrogates the initial IFN-γ-driven burst of IL-12 from these cells (normally triggered by TNF-α-activated NK/NKT cells), leading to increased IL-4, myeloid polarization favoring Listeria growth, and increased susceptibility to infection; IL-4 neutralization restores resistance. Conditional knockout mice (Cre-lox), Listeria monocytogenes infection model, cytokine measurements, IL-4 neutralization epistasis experiment Journal of immunology High 24048899
2014 IFN-γ bound to extracellular vesicles (EVs) through Ifngr1 activates STAT1 in target cells; endogenous Ifngr1 in target cells is required to sustain STAT1 activation by EV-associated IFN-γ/Ifngr1 complexes, establishing a paracrine signaling mechanism mediated by EV-associated receptor–ligand complexes. Co-immunoprecipitation of IFN-γ/Ifngr1 complexes on EVs, siRNA knockdown of Stat1 and Ifngr1 in target cells, STAT1 phosphorylation assays Molecular cell High 25242146
2017 Canonical IFN-γ signaling through Ifngr1 and Stat1 is required for nigrostriatal neurodegeneration and midbrain calcinosis induced by brain Ifn-γ overexpression; Ifngr1-/- mice expressing Ifn-γ show no neuroinflammation, calcinosis, or neurodegeneration, whereas Stat1-/- mice develop gliosis but not neurodegeneration. AAV-mediated Ifn-γ overexpression in Ifngr1-/- and Stat1-/- mice, rotarod behavioral testing, neuropathological analysis Neurobiology of disease Medium 29196213
2017 Type I IFN-mediated downregulation of macrophage cell-surface IFNGR1 (via transcriptional silencing) functionally suppresses macrophage IFN-γ responsiveness and antimicrobial activity in vivo; transgenic macrophages retaining IFNGR1 expression despite type I IFN show enhanced IFN-γ signaling and increased resistance to Listeria monocytogenes infection. Transgenic mice with macrophage-specific FLAG-IFNGR1 expression, Listeria monocytogenes infection model, IFN-γ signaling assays, IFN-γ neutralization PLoS pathogens High 28542482
2019 IFN-γ itself downregulates myeloid cell surface IFNGR1 by reducing Ifngr1 transcription through chromatin remodeling at putative ifngr1 enhancer sites (not by receptor internalization); this ligand-induced IFNGR1 reduction blunts subsequent STAT1 and STAT3 activation, constituting a negative feedback mechanism independent of type I IFNs. Flow cytometry of surface IFNGR1, qRT-PCR, chromatin accessibility assays at ifngr1 enhancers, STAT1/3 phosphorylation assays in murine and human CD14+ cells Life science alliance Medium 31585982
2020 FBXW7 ubiquitin ligase targets IFNGR1 for proteasomal degradation; loss of the ELF5-regulated transcription factor pathway (ELF5→FBXW7) stabilizes IFNGR1 protein in triple-negative breast cancer cells, activating intrinsic IFN-γ signaling, inducing immunosuppressive neutrophil recruitment and PD-L1 expression, and promoting tumor progression and metastasis. Co-immunoprecipitation of FBXW7 and IFNGR1, protein stability assays, ELF5/FBXW7 knockdown/overexpression, IFNGR1 inactivation in mouse TNBC models Nature cell biology High 32284542
2021 IFNGR1 is S-palmitoylated on Cys122; palmitoylated IFNGR1 is recognized by AP3D1 which sorts it to lysosomes for degradation. Optineurin interacts with AP3D1 to prevent this palmitoylation-dependent lysosomal sorting, thereby stabilizing IFNGR1 and maintaining IFN-γ signaling; pharmacological inhibition of IFNGR1 palmitoylation stabilizes IFNGR1 and augments tumor immunity. Palmitoylation assays (acyl-RAC), Co-IP of AP3D1 and IFNGR1/optineurin, site-directed mutagenesis (C122A), lysosomal colocalization imaging, optineurin KO mouse models Cancer discovery High 33627378
2021 Paraspeckle components NEAT1_2 and NONO sequester IFNGR1 mRNA within paraspeckles in hepatocellular carcinoma cells, reducing IFNGR1 protein levels and impairing IFN-γ–IFNGR1 signaling, thereby enabling tumor immune evasion from T-cell killing. S1-aptamer-tagged NEAT1_2 RNA pulldown with mass spectrometry, RNA immunoprecipitation, NEAT1_2/NONO knockdown, T-cell cytolysis assays, IFNGR1 mRNA and protein quantification Cellular and molecular gastroenterology and hepatology Medium 33667716
2023 RGS1 enhances binding of the transcription factor ATF3 to the IFNGR1 promoter, thereby increasing IFNGR1 expression, activating STAT1 and downstream IFN-γ-inducible genes (CXCL9, MHC-I), and promoting CD8+ T-cell infiltration; RGS1 loss reduces IFNGR1 expression and IFN-γ signaling, inducing immunotherapy resistance. ChIP-qPCR, dual-luciferase assay, siRNA knockdown/overexpression, flow cytometry, mouse tumor models Oncoimmunology Medium 38264343
2024 The E3 ubiquitin ligase RNF149 promotes ubiquitylation-dependent proteasomal degradation of IFNGR1 in macrophages; STAT1 activation induces Rnf149 transcription, which in turn destabilizes IFNGR1 to create a negative feedback loop dampening type II IFN signaling in cardiac macrophages after myocardial infarction. Loss of IFNGR1 rescues the deleterious cardiac effects of RNF149 deficiency. Immunoprecipitation/mass spectrometry identifying IFNGR1 as RNF149 substrate, RNF149 KO mice, bone marrow transplantation, adenovirus-mediated RNF149 overexpression, cardiac functional assays, IFNGR1 KO epistasis Circulation research High 38989590
2024 Macrocyclic l-α/d-α/β/γ-hybrid peptide IB1, selected in vitro against IFNGR1, inhibits the IFN-γ/IFNGR1 protein–protein interaction with IC50 = 12 nM in biochemical assay and ~0.75 μM at cellular level, demonstrating that this PPI is pharmacologically tractable. In vitro ribosomal peptide selection (mRNA display), competitive binding assay for IFN-γ/IFNGR1 PPI inhibition, cell-based inhibition assay Journal of the American Chemical Society Medium 38888290
2025 TMEM199 and its partner CCDC115 interact with IFNGR1/2 and facilitate their trafficking to RAB11A-positive recycling endosomes; TMEM199/CCDC115 recruits TRAPP II to activate RAB11A, enhancing IFNGR1/2 recycling and downstream IFN-γ-driven PD-L1 upregulation. Co-immunoprecipitation of TMEM199/CCDC115 with IFNGR1/2, colocalization with RAB11A recycling endosomes, TRAPP II recruitment assay, PD-L1 expression readout Cancer letters Medium 41319859
2006 A deletion/insertion polymorphism (IFNGR1-470del) in the IFNGR1 promoter has context-dependent functional effects: in B-lymphocytes it suppresses binding of a ~35 kDa nuclear protein and increases reporter gene expression, whereas in epithelial cells it suppresses binding of ~90 kDa STAT-1/STAT-2 proteins and decreases IFNGR1 expression, demonstrating cell-type-specific regulation of IFNGR1 transcription. Nuclear protein binding assays (EMSA), IFNGR1 promoter-reporter assays in B-lymphocytes, epithelial cells, and T-lymphocytes Human molecular genetics Medium 16600993
2008 The IFNGR1 -56C/T promoter polymorphism (rs2234711) is functionally relevant: the -56T allele drives ~10-fold higher luciferase reporter expression compared to the -56C allele, indicating this SNP modulates IFNGR1 transcription. Allele-specific luciferase reporter assay for the -56C/T promoter polymorphism Gut Medium 18593809
2023 Porphyromonas gingivalis infection promotes IFNGR1 palmitoylation at Cys122, leading to IFNGR1 colocalization with lysosomal marker LAMP2 and ZDHHC3-mediated lysosomal degradation of IFNGR1, reducing IFNGR1 protein expression and IFN-γ signaling in esophageal cancer cells; C122A mutation partially attenuates Pg-driven cancer cell proliferation/invasion. Western blotting, 2-BP palmitoylation inhibition assay, site-directed mutagenesis (C122A), Click-iT palmitoylation assay, immunofluorescence colocalization with LAMP2, plate cloning/scratch/Transwell assays Journal of Southern Medical University Medium 37488798
2024 SARS-CoV-2 Nsp14 downregulates IFNGR1 (as well as IFNAR1) via a lysosomal pathway, impairing cellular responses to IFN-γ; Tollip knockdown partially reverses IFNGR1 downregulation in SARS-CoV-2-infected cells, indicating Tollip interaction with Nsp14 is relevant for this immune evasion mechanism. N7-MTase domain mutations abolish IFNGR1 downregulation. Nsp14 mutant panel analysis, flow cytometry of IFNGR1 surface expression, siRNA knockdown of Tollip, lysosomal pathway inhibitor experiments in SARS-CoV-2 infected cells bioRxivpreprint Medium

Source papers

Stage 0 corpus · 75 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. Nature genetics 352 10192386
2014 Extracellular vesicles from neural stem cells transfer IFN-γ via Ifngr1 to activate Stat1 signaling in target cells. Molecular cell 248 25242146
2021 Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation. Cancer discovery 104 33627378
2020 Loss of ELF5-FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling. Nature cell biology 89 32284542
2002 IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. The Journal of infectious diseases 80 12023780
2009 NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. Human genetics 68 19575238
2003 Genetic susceptibility to visceral leishmaniasis in The Sudan: linkage and association with IL4 and IFNGR1. Genes and immunity 58 12847550
2000 Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-gamma receptor complex following activation by IFN-gamma. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 58 10888113
1997 Infections in IFNGR-1-deficient children. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 58 9355958
2013 Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1). Journal of immunology (Baltimore, Md. : 1950) 55 24048899
2007 Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes. Human genetics 52 17431682
2006 IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFN-gamma-activated genes: evidence of transactivational activity in IFNGR1. Journal of immunology (Baltimore, Md. : 1950) 45 16785527
2013 Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription. Journal of immunology (Baltimore, Md. : 1950) 43 23935197
2008 The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma. Gut 43 18593809
2006 IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan. Genes and immunity 37 17136124
2017 IFN-γR1 defects: Mutation update and description of the IFNGR1 variation database. Human mutation 36 28744922
2015 Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. The Journal of allergy and clinical immunology 36 26343451
2014 Genetic polymorphisms of IFNG and IFNGR1 in association with the risk of pulmonary tuberculosis. Gene 32 24680779
2009 A novel form of cell type-specific partial IFN-gammaR1 deficiency caused by a germ line mutation of the IFNGR1 initiation codon. Human molecular genetics 30 19880857
2022 Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling. Oncogene 27 35027670
2012 An association study of functional polymorphic genes IRF-1, IFNGR-1, and IFN-γ with disease progression, aspartate aminotransferase, alanine aminotransferase, and viral load in chronic hepatitis B and C. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 27 23040881
1999 Nonpathogenic common variants of IFNGR1 and IFNGR2 in association with total serum IgE levels. Biochemical and biophysical research communications 27 10491309
2007 The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-gamma receptor 1 and has a dominant-negative effect on interferon-gamma signal transduction. Journal of medical genetics 25 17513528
2017 Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection. PLoS pathogens 24 28542482
2021 Genetic Association of a Gain-of-Function IFNGR1 Polymorphism and the Intergenic Region LNCAROD/DKK1 With Behçet's Disease. Arthritis & rheumatology (Hoboken, N.J.) 23 33393726
1989 Human interferon gamma receptor 1 (IFNGR1) gene maps to chromosome region 6q23-6q24. Human genetics 23 2532616
2010 Analysis of functional SNP in ifng/ifngr1 in Chinese Han population with tuberculosis. Scandinavian journal of immunology 19 20500698
2019 Genetic variants in IFNG and IFNGR1 and tuberculosis susceptibility. Cytokine 17 31310896
2006 Context-specific functional effects of IFNGR1 promoter polymorphism. Human molecular genetics 17 16600993
2019 Mice lacking Casp1, Ifngr and Nos2 genes exhibit altered depressive- and anxiety-like behaviour, and gut microbiome composition. Scientific reports 16 31015500
2011 Initial interrogation, confirmation and fine mapping of modifying genes: STAT3, IL1B and IFNGR1 determine cystic fibrosis disease manifestation. European journal of human genetics : EJHG 16 21731057
2018 Analysis of the expression patterns of the cytokine receptor family B (CRFB) and interferon gamma receptor (IFNGR) in Dabry's sturgeon (Acipenser dabryanus). Developmental and comparative immunology 15 29555551
2023 Cancer cell-derived extracellular vesicles drive pre-metastatic niche formation of lymph node via IFNGR1/JAK1/STAT1-activated-PD-L1 expression on FRCs in head and neck cancer. Oral oncology 14 37482043
2022 IFN-γ promotes the development of systemic lupus erythematosus through the IFNGR1/2-PSTAT1-TBX21 signaling axis. American journal of translational research 14 36398225
2021 Induced Mitochondrial Alteration and DNA Damage via IFNGR-JAK2-STAT1-PARP1 Pathway Facilitates Viral Hepatitis Associated Hepatocellular Carcinoma Aggressiveness and Stemness. Cancers 14 34199353
2003 Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. Immunogenetics 14 12743658
2021 Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNA. Cellular and molecular gastroenterology and hepatology 13 33667716
2019 Analysis of interferon-γ receptor IFNGR1 and IFNGR2 expression and regulation at the maternal-conceptus interface and the role of interferon-γ on endometrial expression of interferon signaling molecules during early pregnancy in pigs. Molecular reproduction and development 13 31680343
2019 Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis Infection. Disease markers 13 31687049
2014 Two IFNGR1 homologues in Tetraodon nigroviridis: Origin, expression analysis and ligand-binding preference. Developmental and comparative immunology 13 24412214
2017 IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites. PloS one 12 29117241
2024 RNF149 Destabilizes IFNGR1 in Macrophages to Favor Postinfarction Cardiac Repair. Circulation research 11 38989590
2023 Tumor-intrinsic RGS1 potentiates checkpoint blockade response via ATF3-IFNGR1 axis. Oncoimmunology 11 38264343
2020 Promoting effect of long non-coding RNA SNHG1 on osteogenic differentiation of fibroblastic cells from the posterior longitudinal ligament by the microRNA-320b/IFNGR1 network. Cell cycle (Georgetown, Tex.) 11 33017569
2017 Association of IFNGR1 and IFNG genetic polymorphisms with the risk for pulmonary tuberculosis in the Chinese Tibetan population. Oncotarget 11 29228700
2017 Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration. Neurobiology of disease 10 29196213
2014 Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 10 24453034
2015 Association of Genetic Polymorphisms of IFNGR1 with the Risk of Pulmonary Tuberculosis in Zahedan, Southeast Iran. Tuberculosis research and treatment 9 26649196
2009 IFNGR1 polymorphisms in Thai malaria patients. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 9 19712753
2014 Insights into the possible role of IFNG and IFNGR1 in Kala-azar and Post Kala-azar Dermal Leishmaniasis in Sudanese patients. BMC infectious diseases 7 25466928
2023 [Effect of Porphyromonas gingivalis infection on IFNGR1 palmitoylation in esophageal cancer cells]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 6 37488798
2024 In Vitro Selection of Macrocyclic l-α/d-α/β/γ-Hybrid Peptides Targeting IFN-γ/IFNGR1 Protein-Protein Interaction. Journal of the American Chemical Society 5 38888290
2023 S100A9 upregulated by IFNGR signaling blockade functions as a novel GVHD suppressor without compromising GVL in mice. Blood 5 36477272
2019 Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsiveness. Life science alliance 5 31585982
2019 Disseminated Mycobacterium Avium Infection in a Child with Complete Interferon-γ Receptor 1 Deficiency due to Compound Heterozygosis of IFNGR1 for a Subpolymorphic Copy Number Variation and a Novel Splice-Site Variant. Journal of pediatric genetics 5 32714620
2010 Lack of association between IFNGR1 gene polymorphisms and biopsy-proven giant cell arteritis. Clinical and experimental rheumatology 5 20412699
2022 Case Report: Disseminated Mycobacterium intracellulare Infection With More Than 1-Year Follow-Up in a Young Boy With IFNGR1 Deficiency. Frontiers in pediatrics 4 35281241
2022 Interferon gamma upregulates the cytokine receptors IFNGR1 and TNFRSF1A in HT-29-MTX E12 cells. Cytokine 4 35653895
2024 CAV1 inhibits Xc- system through IFNGR1 to promote ferroptosis to inhibit stemness and improves anti-PD-1 efficacy in breast cancer. Translational oncology 3 39395272
2024 The aqueous extract of Armadillidium vulgare Latreille alleviates neuropathic pain via inhibiting neuron-astrocyte crosstalk mediated by the IL-12-IFN-γ-IFNGR-CXCL10 pathway. Journal of ethnopharmacology 3 39617087
2022 Association between IFNGR1 gene polymorphisms and tuberculosis susceptibility: A meta-analysis. Frontiers in public health 3 36148347
2022 IFNG and IFNGR1 polymorphisms are associated with tuberculosis: a case-control study. European review for medical and pharmacological sciences 3 36524496
2021 Genetic Polymorphisms of IFNG, IFNGR1, and Androgen Receptor and Chronic Prostatitis/Chronic Pelvic Pain Syndrome in a Chinese Han Population. Disease markers 3 34646402
2016 Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions. Bosnian journal of basic medical sciences 3 27356097
2024 Elevated NS1 serum levels reduce CD119 expression and CXCL-10 synthesis in patients with dengue hemorrhagic fever. Revista da Sociedade Brasileira de Medicina Tropical 2 39082520
2023 Identification, functional characterization and expression pattern of interferon-gamma (IFN-γ) and interferon-gamma receptor 1 (IFNGR1) in Nibea albiflora. Fish & shellfish immunology 2 38072135
2008 Frequent mutations in the 3'-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours. European journal of human genetics : EJHG 2 18414508
2025 TMEM199 promotes PD-L1 expression and tumor immune evasion by activating the recycling of IFNGR1/2. Cancer letters 1 41319859
2006 IFNGR1 single nucleotide polymorphisms in rheumatoid arthritis. Arthritis research & therapy 1 16563189
2025 IFNGR1, IRF8 genetic polymorphisms modulate the susceptibility of non-tuberculous mycobacteria pulmonary disease and influence the patients' treatment outcomes and immune status. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 0 40691380
2025 Ubiquitin-related Protein IFNGR1 as Causal Factor and Drug Target for Keloids: A Mendelian Randomization Analysis. Plastic and reconstructive surgery. Global open 0 40827246
2025 Functional Role of Single-Nucleotide Polymorphisms on IFNG and IFNGR1 in Humans with Cardiovascular Disease. International journal of molecular sciences 0 41009374
2023 [Analysis of IFN-γR1 (CD119) and IL-12Rβ1 (CD212) Deficiency by Flow Cytometry]. Mikrobiyoloji bulteni 0 36636848
2023 Talaromyces marneffei infection with IFNGR1 gene mutation in a patient with negative Anti-Interferon-γ autoantibodies. Anais brasileiros de dermatologia 0 37926601
1992 TaqI RFLP in the interferon gamma receptor 1 gene (IFNGR1) on human chromosome 6q. Nucleic acids research 0 1372404