ADP-ribosylation factor-binding protein GGA1 · UniProt Q9UJY5
GGA1 is a modular monomeric clathrin adaptor that sorts transmembrane cargo between the trans-Golgi network (TGN) and the endosomal system, dynamically cycling on and off TGN membranes and clathrin-coated vesicular-tubular carriers together with clathrin and AP-1 (PMID:12686608). Its N-terminal VHS domain is the cargo-recognition module: a super-helix of eight alpha-helices that binds acidic-cluster dileucine (ACLL/DXXLL) motifs in the cytosolic tails of sorting receptors such as the cation-independent mannose-6-phosphate receptor, with helices α6 and α8 forming the electrostatic and hydrophobic contacts (PMID:11859376), and it engages a structurally related class of cargo including BACE/memapsin 2 and the Vps10p-domain receptor sorLA (PMID:12135764, PMID:11821067). Cargo binding is tuned by phosphorylation: phospho-serine in the BACE DISLL motif strengthens VHS engagement by creating an additional hydrogen bond and electrostatic contact (PMID:15117318, PMID:15466887), while an intramolecular acidic-cluster dileucine sequence in the hinge, when phosphorylated by casein kinase 2, folds back onto the VHS ligand site to autoinhibit cargo binding (PMID:12060753). The GAT domain is a helix bundle whose N-terminal extension binds ARF for TGN recruitment and whose C-terminal three-helix bundle binds the Rabaptin-5 coiled-coil through a hydrophobic patch in an ARF-independent, helix-bundle-to-helix-bundle mode (PMID:12668765, PMID:12767220, PMID:14636058, PMID:16473621); phosphorylation within the GAT domain at S268/T270 controls Golgi membrane association and coat dissociation (PMID:14690499). The hinge recruits AP-1 via a WNSF motif that competes with Rabaptin-5 for the γ-ear (PMID:14973137), and the GAE domain binds this same hinge WNSF sequence competitively with accessory proteins to provide a further autoregulatory layer (PMID:17506864); GGA1 also drives clathrin polymerization into both baskets and tubules (PMID:17344219). Through these activities GGA1 governs the subcellular itinerary of multiple cargoes: it confines APP and BACE1 to the Golgi and routes phospho-BACE1 from early to recycling endosomes in cooperation with retromer, thereby lowering amyloid-β production (PMID:17005855, PMID:17151287, PMID:29142073), directs cell-surface delivery of the α2B-adrenergic receptor via a direct hinge–third-intracellular-loop contact (PMID:27901063), maintains endosomal localization and luminal pH homeostasis through the Na+/H+ exchanger NHE6 (PMID:39002678), and couples the polycystin-1/2 complex to an Arl3-dependent ciliary targeting module (PMID:25405894). GGA1 and GGA3 act synergistically to restrain neuronal BACE1 levels, and GGA1 is a caspase-3 substrate depleted after traumatic brain injury (PMID:22836275).
Established the structural basis of GGA1 cargo recognition, answering how the VHS domain reads acidic-cluster dileucine sorting signals.
Evidence X-ray structures of apo and CI-MPR peptide-bound VHS domain
Revealed that GGA1 cargo binding is autoinhibited, answering how the adaptor is switched off when not engaged at the TGN.
Evidence In vitro binding with truncations, domain-swap into GGA2, and CK2 phosphorylation assays
Broadened the cargo repertoire beyond MPRs, showing GGA1 binds the beta-secretase BACE/memapsin 2 and the receptor sorLA, linking the adaptor to amyloidogenic and Vps10p-domain cargo.
Evidence VHS-domain pulldowns and cytosolic-tail mutagenesis of memapsin 2 and sorLA
Demonstrated GGA1 dynamics in cells, answering whether GGA1 acts as a stable coat or a rapidly cycling adaptor at the TGN.
Evidence Live multicolor fluorescence imaging and FRAP of GFP-GGA1, clathrin, and AP-1
Solved the GAT domain structure and partitioned its ARF- and Rabaptin-5-binding surfaces, explaining how GGA1 is recruited to TGN versus endosomal membranes.
Evidence Crystal structures of the GAT domain plus structure-based mutagenesis and binding assays
PMID:12668765 PMID:12767220 PMID:14636058 PMID:16473621
Showed phosphorylation tunes cargo affinity, answering how cells regulate GGA1 binding to BACE in space and time.
Evidence Crystal structure of VHS bound to phospho-BACE peptide, quantitative binding, and FLIM-FRET with phosphomutants in cells
Mapped the hinge WNSF motif to the AP-1 gamma-ear and showed it competes with Rabaptin-5, defining a shared interaction surface for accessory recruitment.
Evidence Reciprocal mutagenesis and competitive peptide binding for GGA1 hinge and AP-1 gamma-ear
Identified GAT-domain phosphosites controlling membrane association, linking post-translational modification to coat dissociation kinetics.
Evidence Mass spectrometry phosphosite mapping plus phosphomimetic localization analysis
Demonstrated GGA1 directly assembles clathrin and resolved an additional GAE-hinge autoregulatory loop, completing the modular regulatory picture.
Evidence In vitro clathrin assembly with EM, plus GAE-hinge peptide crystal structure and competition assays
Established GGA1 as a spatial regulator of amyloidogenic processing, showing it confines APP/BACE1 to the Golgi to suppress Abeta production.
Evidence Overexpression, RNAi, FRET, and domain-deletion analysis with Abeta ELISA
Defined paralog-specific roles, showing GGA1 alone is required for LR11/SorLA endocytic traffic and that GGA1 and GGA3 synergistically restrain neuronal BACE1.
Evidence Isoform-specific siRNA across three GGAs, APP processing assays, caspase-3 cleavage, and mouse TBI model
Resolved the directionality of BACE1 sorting, showing GGA1 moves phospho-BACE1 from early to recycling endosomes with retromer to lower Abeta.
Evidence BACE1 phosphomutants, GGA1 and retromer siRNA, endosomal trafficking kinetics, Abeta ELISA in primary neurons
Extended GGA1 function to GPCR surface delivery, showing the hinge directly contacts the alpha2B-adrenergic receptor third intracellular loop to enable export and downstream signaling.
Evidence Knockdown, surface ELISA, signaling assays, Co-IP and domain mapping
Identified a dominant-negative GGA1 splice variant, showing isoform diversity can block adaptor function via dimerization and loss of cargo/clathrin binding.
Evidence GGA1t overexpression, surface receptor assays, Co-IP dimerization, TGN clathrin recruitment assay
Linked GGA1 to myogenesis and insulin receptor sorting, broadening its cargo and developmental relevance.
Evidence siRNA in C2C12 myoblasts, myotube morphology, lysosomal protease inhibition, insulin receptor immunoblot
Defined GGA1 control of organellar pH, showing it binds the NHE6 tail to maintain endosomal localization and Golgi luminal pH.
Evidence Y2H, endogenous Co-IP, domain-swaps, KO fractionation, super-resolution imaging, luminal pH measurement
Placed GGA1 in ciliary trafficking, showing it couples the polycystin complex to an Arl3-dependent module at the TGN.
Evidence Yeast two-hybrid, Co-IP, and siRNA with ciliary localization readout
Proposed a signaling input retaining oncogenic KIT at the Golgi via GGA1, but the pathway is only partially defined.
Evidence PLD inhibitor and PLD1/2 siRNA, gamma-adaptin-GGA1 Co-IP, localization assays (preprint)
PMID:bio_10.1101_2025.03.02.640696
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 2002 | X-ray crystal structure of the GGA1 VHS domain alone and in complex with the cation-independent mannose 6-phosphate receptor (CI-MPR) C-terminal peptide containing an acidic-cluster dileucine (ACLL) sequence revealed that the VHS domain forms a super-helix of eight alpha-helices; recognition of ACLL motifs involves unidirectional movements of helices α6 and α8 creating electrostatic and hydrophobic interactions. | X-ray crystallography (crystal structures of apo and peptide-bound VHS domain) | Nature | High | 11859376 |
| 2002 | Full-length cytoplasmic GGA1 (and GGA3 but not GGA2) is autoinhibited in its ability to bind the CI-MPR because an acidic-cluster dileucine (AC-LL) sequence in the hinge segment binds to the VHS domain ligand-binding site; this autoinhibition depends on phosphorylation of a serine three residues upstream of the AC-LL motif by casein kinase 2. | In vitro binding assays with full-length and truncated GGA constructs, site-directed mutagenesis, in vitro casein kinase 2 phosphorylation assay, substitution of GGA1 inhibitory sequence into GGA2 | Proceedings of the National Academy of Sciences of the United States of America | High | 12060753 |
| 2002 | The VHS domains of GGA1 and GGA2 bind the cytosolic domain of memapsin 2 (beta-secretase/BACE); Asp496, Leu499, and Leu500 in the memapsin 2 cytosolic tail are essential for this interaction, mirroring the spacing found in mannose-6-phosphate receptor cytosolic domains. | Gel-immobilized VHS domain pulldown from cell lysates, site-directed mutagenesis of memapsin 2 cytosolic tail | FEBS letters | Medium | 12135764 |
| 2002 | The cytoplasmic domain of the Vps10p-domain receptor sorLA binds GGA1 and GGA2 via three critical C-terminal residues that conform to a minimal GGA-binding motif (ψ-ψ-X-X-φ) that lacks a classical acidic cluster or dileucine. | In vitro binding assays, mutagenesis of sorLA cytoplasmic tail | FEBS letters | Medium | 11821067 |
| 2003 | Live-cell fluorescence imaging showed that GGA1, clathrin, and AP-1 colocalize at the TGN and on pleomorphic vesicular-tubular carriers (up to 10 µm displacement at ~1 µm/s) that bud from the TGN; GGA1 and clathrin cycle on and off membranes with half-times of 10–20 s independently of vesicle budding. | Live fluorescence imaging with GFP-tagged GGA1, clathrin, and AP-1; FRAP | Molecular biology of the cell | High | 12686608 |
| 2003 | Crystal structure of the GGA1 GAT domain at 2.4 Å revealed a three-helix bundle with a long N-terminal helical extension; the ARF-binding site resides in the N-terminal extension, and the core three-helix bundle shares structural homology with the N-terminal domain of syntaxin 1a. | X-ray crystallography at 2.4 Å resolution | Proceedings of the National Academy of Sciences of the United States of America | High | 12668765 |
| 2003 | The 2.8 Å crystal structure of the GGA1 GAT domain revealed four helices; the conserved N-terminal helix-loop-helix motif harbors a hydrophobic ARF-binding patch, and the C-terminal three-helix bundle is responsible for rabaptin-5 binding, as confirmed by structure-based mutagenesis. | X-ray crystallography at 2.8 Å, structure-based mutagenesis and biochemical binding assays | Biochemistry | High | 12767220 |
| 2003 | The C-terminal three-helix bundle of the GGA1 GAT domain mediates binding to the coiled-coil region of Rabaptin-5 through a hydrophobic surface patch; the GGA1-specific residue N284 (vs. S293 in GGA3) accounts for the differential Rabaptin-5 binding among GGA family members, and GAT–Rabaptin-5 binding is independent of ARF binding. | Site-directed mutagenesis, in vitro pulldown/binding assays, crystal-structure-guided interpretation | Biochemistry | High | 14636058 |
| 2004 | The BACE cytosolic DISLL motif is recognized by the GGA1 VHS domain; phosphorylation of the serine in this motif enhances binding affinity ~3-fold. The crystal structure of the GGA1 VHS domain bound to the phosphorylated BACE peptide showed that phospho-serine alters the lysine side chain and backbone, creating an additional hydrogen bond and stronger electrostatic interaction. | X-ray crystallography of VHS–BACE peptide complex, quantitative binding assays with phosphorylated and unphosphorylated peptides | Traffic (Copenhagen, Denmark) | High | 15117318 |
| 2004 | Fluorescence lifetime imaging microscopy (FLIM/FRET) in intact cells demonstrated that GGA1 interacts with phosphorylated BACE in juxtanuclear compartments; serine phosphorylation of BACE regulates its interaction with GGA1 in cells, and non-phosphorylatable or pseudo-phosphorylated BACE mutants remain colocalized with GGA1 at the Golgi. | FLIM-FRET in live/fixed cells, phosphomimetic and non-phosphorylatable BACE mutants | Journal of cell science | High | 15466887 |
| 2004 | GGA1 interacts with the AP-1 gamma-ear through a WNSF sequence (W382-N383-S384-F385) in its hinge region; Trp and Phe are critical residues; this WXXF-type motif competes with Rabaptin-5 FXXPhi-type binding for the same or overlapping site on the AP-1 gamma-ear. | In vitro binding assays, competitive inhibition with peptides, site-directed mutagenesis of GGA1 hinge and AP-1 gamma-ear | The Journal of biological chemistry | High | 14973137 |
| 2004 | Glu58 and Glu59 of the CD-MPR CK2 acidic cluster site are essential for high-affinity GGA1 binding in vitro; phosphorylation of Ser57 does not influence GGA1 binding to CD-MPR. The binding affinity of GGA1 to CD-MPR is 2.4-fold higher than that of AP-1. | In vitro binding assays with phosphopeptides and mutant CD-MPR cytoplasmic tail peptides, quantitative affinity measurements | The Journal of biological chemistry | Medium | 15044437 |
| 2004 | GGA1 phosphorylation at S268 and T270 in the GAT domain (identified by tandem mass spectrometry) causes redistribution from Golgi/TGN to cytoplasmic puncta when phosphomimetic mutations are introduced; this phosphorylation regulates the rate of GGA1 coat dissociation from vesicles. | Tandem mass spectrometry to identify phosphorylation sites, expression of phosphomimetic HA-GGA1 mutants in mammalian cells, quantitative colocalization with Golgi/TGN markers | Traffic (Copenhagen, Denmark) | Medium | 14690499 |
| 2006 | GGA1 overexpression in cultured cells increased APP C-terminal fragment from beta-cleavage but reduced Abeta production; FRET analysis showed GGA1 confines APP to the Golgi where the two proteins come into close proximity; the GAT domain integrity is required for these effects, and direct GGA1–BACE binding is not required. | Overexpression and dominant-negative constructs, FRET, subcellular fractionation, domain deletion/mutation analysis | The Journal of neuroscience | Medium | 17005855 |
| 2006 | GGA1 overexpression reduces Abeta secretion while RNAi-mediated knockdown increases Abeta secretion; GGA1 modulates APP processing by affecting subcellular trafficking of BACE1, independent of direct GGA1–APP interaction, and without altering total cellular BACE1 activity. | GGA1 overexpression and siRNA knockdown in cultured cells, Abeta ELISA, APP processing assays | The Journal of neuroscience | Medium | 17151287 |
| 2007 | GGA1 promotes assembly of clathrin in vitro; full-length GGA1 polymerizes clathrin into both baskets and tubules (~180 nm long, ~50 nm wide); the hinge+GAE fragment assembles clathrin only into baskets; maximum clathrin assembly occurs at one GGA1 per heavy chain. | In vitro clathrin assembly assay with purified components, electron microscopy to determine structure of assembled complexes | The Journal of biological chemistry | High | 17344219 |
| 2007 | The GGA1 GAE domain crystal structure in complex with its own hinge WNSF peptide revealed that the two aromatic residues fit into a hydrophobic groove of the GAE domain; the hinge region competes with accessory proteins and AP-1 for GAE binding, establishing an autoregulatory mechanism for GGA1 in clathrin-mediated trafficking. | X-ray crystallography of GAE–hinge peptide complex, fluorescence quenching competition assays | Traffic (Copenhagen, Denmark) | High | 17506864 |
| 2012 | GGA1 silencing potentiates BACE1 elevation induced by GGA3 deletion in neurons in vitro, indicating that GGA1 and GGA3 synergistically regulate BACE1 levels; GGA1 is a caspase-3 substrate that is depleted after traumatic brain injury. | siRNA knockdown in primary neurons, caspase-3 cleavage assays, mouse TBI model, immunoblotting | The Journal of neuroscience | Medium | 22836275 |
| 2012 | siRNA knockdown of GGA1 (but not GGA2 or GGA3) disrupts LR11/SorLA endosomal trafficking and prevents LR11-mediated and BACE1-mediated modulation of APP processing to Abeta; GGA1 is specifically required for LR11 endocytic traffic. | siRNA knockdown of individual GGA family members, APP processing assays, BACE1 mutagenesis (S498A), subcellular localization by immunofluorescence | Molecular biology of the cell | Medium | 22621900 |
| 2014 | GGA1 functions in a Rabep1/GGA1/Arl3-dependent ciliary targeting mechanism at the TGN; GGA1 couples the polycystin-1/polycystin-2 complex (identified by yeast two-hybrid) to an Arl3-based ciliary trafficking module, enabling trafficking of these large membrane proteins to cilia. | Yeast two-hybrid screening, candidate approach, co-immunoprecipitation, siRNA knockdown with ciliary localization readout | Nature communications | Medium | 25405894 |
| 2017 | GGA1 mediates rapid trafficking of phosphorylated BACE1 (phospho-S498, DISLL motif) from early endosomes to recycling endosomes; the phosphomimetic S498D mutant exits early endosomes faster and shows reduced APP processing and Abeta production; retromer cooperates with GGA1 in this pathway. | Phosphomimetic/non-phosphorylatable BACE1 mutants, siRNA knockdown of GGA1 and retromer, quantitative endosomal trafficking assays, Abeta ELISA, primary neuron experiments | Molecular biology of the cell | High | 29142073 |
| 2016 | GGA1 and GGA2 are required for cell surface transport of α2B-adrenergic receptor (α2B-AR); knockdown of GGA1 arrests α2B-AR in the perinuclear region and attenuates ERK1/2 activation and cAMP inhibition; the GGA1 hinge region directly interacts with the third intracellular loop of α2B-AR. | shRNA/siRNA knockdown, cell surface ELISA, receptor-mediated signaling assays, co-immunoprecipitation, domain mapping | Scientific reports | Medium | 27901063 |
| 2019 | A naturally occurring truncated splice variant of GGA1 (GGA1t), lacking the N-terminal hinge portion, acts as a dominant-negative inhibitor of α2B-AR cell surface export; GGA1t forms homodimers and heterodimers with full-length GGA1, is unable to bind cargo α2B-AR, and cannot recruit clathrin to the TGN. | Overexpression of GGA1t, cell surface receptor assays, Co-IP for dimerization, clathrin recruitment assay at TGN | Scientific reports | Medium | 31316103 |
| 2018 | GGA1 is required for myotube formation in C2C12 myoblasts; Gga1 depletion by RNAi prevents formation of large multi-nucleated myotubes; GGA1 is involved in cell surface expression and sorting of the insulin receptor, as inhibition of lysosomal proteases in GGA1-knockdown cells increased insulin receptor levels. | siRNA knockdown in C2C12 cells, morphological analysis of myotube formation, lysosomal protease inhibition, insulin receptor immunoblotting | PloS one | Medium | 30440034 |
| 2024 | GGA1 interacts with the endosomal Na+/H+ exchanger NHE6 (and organellar NHEs 6, 7, 9 but not surface NHEs 1 and 5) via the NHE6 cytoplasmic tail; GGA1 knockout causes NHE6 mislocalization — less NHE6 in endosomes, more in lysosomes and Golgi, with increased surface exocytosis — and alkalinization of Golgi luminal pH. | Yeast two-hybrid screening, reciprocal co-immunoprecipitation (overexpressed and endogenous), hybrid NHE1/NHE6 domain-swap constructs, subcellular fractionation in GGA1 KO cells, super-resolution microscopy co-localization, luminal pH measurement | The Journal of biological chemistry | High | 39002678 |
| 2025 | In GIST cells, a constitutively active KIT mutant activates the PLCγ2–PKD2–PLD2 cascade, which promotes association of γ-adaptin with GGA1 at the Golgi/TGN; PLD activity is required for GGA1-dependent Golgi/TGN retention of KIT mutant, and PLD inhibition releases KIT mutant from the Golgi for lysosomal degradation. | PLD inhibitor treatment, siRNA knockdown of PLD1/PLD2, co-immunoprecipitation of γ-adaptin with GGA1, subcellular localization assays | bioRxivpreprint | Low | bio_10.1101_2025.03.02.640696 |
| 2005 | In vitro biochemical characterization combined with the GAT–Rabaptin-5 complex crystal structure established that the binding mode between the GGA1 GAT domain and Rabaptin-5 is helix-bundle-to-helix-bundle in nature. | In vitro binding assays, crystal structure of GGA1 GAT–Rabaptin-5 complex | Methods in enzymology | Medium | 16473621 |
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2002 | Structural basis for recognition of acidic-cluster dileucine sequence by GGA1. | Nature | 124 | 11859376 |
| 2003 | Morphology and dynamics of clathrin/GGA1-coated carriers budding from the trans-Golgi network. | Molecular biology of the cell | 103 | 12686608 |
| 2002 | Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2. | FEBS letters | 101 | 12135764 |
| 2014 | Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism. | Nature communications | 97 | 25405894 |
| 2002 | The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. | FEBS letters | 97 | 11821067 |
| 2004 | Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy. | Journal of cell science | 90 | 15466887 |
| 2006 | GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 75 | 17151287 |
| 2002 | Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. | Proceedings of the National Academy of Sciences of the United States of America | 72 | 12060753 |
| 2004 | Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1. | Traffic (Copenhagen, Denmark) | 57 | 15117318 |
| 2012 | Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 54 | 22836275 |
| 2012 | GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production. | Molecular biology of the cell | 53 | 22621900 |
| 2006 | GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 52 | 17005855 |
| 2017 | GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production. | Molecular biology of the cell | 50 | 29142073 |
| 2003 | Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor. | Proceedings of the National Academy of Sciences of the United States of America | 38 | 12668765 |
| 2004 | GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region. | The Journal of biological chemistry | 34 | 14973137 |
| 2003 | Crystal structure of the human GGA1 GAT domain. | Biochemistry | 30 | 12767220 |
| 2016 | Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2. | Scientific reports | 17 | 27901063 |
| 2003 | The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle. | Biochemistry | 17 | 14636058 |
| 2004 | Multiple phosphorylation events regulate the subcellular localization of GGA1. | Traffic (Copenhagen, Denmark) | 16 | 14690499 |
| 2004 | The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding. | The Journal of biological chemistry | 16 | 15044437 |
| 2007 | Clathrin adaptor GGA1 polymerizes clathrin into tubules. | The Journal of biological chemistry | 13 | 17344219 |
| 2007 | Molecular basis for autoregulatory interaction between GAE domain and hinge region of GGA1. | Traffic (Copenhagen, Denmark) | 11 | 17506864 |
| 2018 | Clathrin adaptor GGA1 modulates myogenesis of C2C12 myoblasts. | PloS one | 9 | 30440034 |
| 2023 | Total flavonoids of Rhizoma drynariae improves tendon-bone healing for anterior cruciate ligament reconstruction in mice and promotes the osteogenic differentiation of bone mesenchymal stem cells by the ERR1/2-Gga1-TGF-β/MAPK pathway. | Environmental toxicology | 8 | 37665165 |
| 2014 | GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells. | Biochemical and biophysical research communications | 4 | 24866237 |
| 2024 | GGA1 interacts with the endosomal Na+/H+ exchanger NHE6 governing localization to the endosome compartment. | The Journal of biological chemistry | 3 | 39002678 |
| 2023 | GGA1 participates in spermatogenesis in mice under stress. | PeerJ | 3 | 37551344 |
| 2019 | A Naturally Occurring Splice Variant of GGA1 Inhibits the Anterograde Post-Golgi Traffic of α2B-Adrenergic Receptor. | Scientific reports | 3 | 31316103 |
| 2005 | Analysis of the interaction between GGA1 GAT domain and Rabaptin-5. | Methods in enzymology | 2 | 16473621 |
| 2023 | GGA1 interacts with the endosomal Na+/H+ Exchanger NHE6 governing localization to the endosome compartment. | bioRxiv : the preprint server for biology | 1 | 37986849 |
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