Affinage

FTL

Ferritin light chain · UniProt P02792

Length
175 aa
Mass
20.0 kDa
Annotated
2026-06-09
44 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FTL (ferritin light chain) is a subunit of the ferritin iron-storage complex that buffers intracellular labile iron and thereby gates iron-dependent oxidative cell death (ferroptosis), with its loss in multiple tissues triggering iron accumulation, lipid peroxidation, and ferroptotic and senescent phenotypes (PMID:42177202, PMID:35249107). Direct biochemical and transgenic evidence establishes that the iron-storage function depends on FTL's C-terminus: a frameshift extending the C-terminus severely impairs iron storage and, in transgenic mice, drives brain iron deposition, oxidative damage, and progressive motor deficits, the basis of neuroferritinopathy (PMID:25447222). FTL translation is normally restrained by the iron-responsive element in its 5'-UTR; disruption of this control—via IRE mutation or loss of the transcription start site—causes constitutive FTL over-translation and hereditary hyperferritinemia cataract syndrome (PMID:16518306, PMID:17579362). Beyond translational control, FTL protein levels are set by competing post-translational inputs: the E3 ubiquitin ligase HERC2 ubiquitinates FTL to promote its degradation and drive ferroptosis (PMID:41854786), whereas SIRT1-mediated deacetylation at K181 stabilizes FTL and suppresses ferroptosis (PMID:39786573), and NSUN5-dependent m5C methylation of FTL mRNA maintains FTL protein in a TRAP1-dependent manner (PMID:35249107). FTL transcription is positively controlled by HIF-1α (HRE-3), SPI1, and GATA3 (PMID:32677981, PMID:39675923, PMID:40421527). In cancer, FTL supports proliferation and invasion—it localizes to the nucleus and mitotic spindle, binds GADD45A to suppress the GADD45A/JNK growth-inhibitory pathway in glioblastoma, and promotes glioma EMT via AKT/GSK3β/β-catenin signaling (PMID:26871431, PMID:32677981). In neurons, elevated FTL1 alters labile iron oxidation states to impair ATP synthesis and synaptic function, promoting hippocampal aging (PMID:40830655).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1997 Medium

    Establishing the genomic location of FTL provided the anchor for subsequent linkage of inherited iron-storage and cataract syndromes to the locus.

    Evidence FISH mapping to human chromosome 19q13.3

    PMID:9526618

    Open questions at the time
    • Localization alone gives no functional or regulatory information
    • Does not connect the gene to any phenotype
  2. 2006 Medium

    Family genetics resolved how distinct FTL lesions cause opposite clinical phenotypes—IRE mutations de-repress translation to cause hyperferritinemia, while coding mutations impair iron storage to cause neurodegeneration.

    Evidence Linkage and sequencing of the IRE (HHCS) and a missense allele (neuroferritinopathy) with serum ferritin measurement

    PMID:16116125 PMID:16518306

    Open questions at the time
    • A96T mutant protein was not biochemically characterized in vitro
    • Mechanism linking reduced iron storage to pallidal neurodegeneration not established
  3. 2007 Medium

    A promoter deletion abolishing the transcription start site showed that loss of normal start-site usage forces transcription from within the IRE stem, de-repressing FTL translation—broadening the molecular routes to HHCS beyond point IRE mutations.

    Evidence Promoter/IRE sequencing and expression analysis in lymphoblastoid cells from a kindred

    PMID:17579362

    Open questions at the time
    • Single kindred
    • Quantitative contribution of the alternate start site versus IRE disruption not separated
  4. 2014 High

    Direct biochemistry on purified mutant protein plus a transgenic model causally connected a C-terminal frameshift to defective iron storage and age-dependent neurodegeneration, defining the disease mechanism of neuroferritinopathy.

    Evidence Cyclic voltammetry on purified protein and FVB transgenic mice with MRI, rotarod, and ultrastructure

    PMID:25447222

    Open questions at the time
    • Whether mutant subunits act dominant-negatively within mixed ferritin shells not resolved
    • Cell-type specificity of brain iron deposition not dissected
  5. 2016 Medium

    FTL was shown to have a non-canonical pro-proliferative role independent of iron storage, physically engaging GADD45A to block the GADD45A/JNK growth-inhibitory axis in glioblastoma.

    Evidence Immunofluorescence, reciprocal co-immunoprecipitation, siRNA knockdown, and viability assays in GBM cells

    PMID:26871431

    Open questions at the time
    • Nuclear/spindle localization mechanism for FTL not explained
    • Direct binding interface with GADD45A not mapped
  6. 2020 Medium

    FTL was placed downstream of hypoxic signaling, with HIF-1α directly activating FTL transcription and FTL driving EMT and invasion in glioma.

    Evidence Luciferase reporter and ChIP for HRE-3 binding, knockdown with migration/invasion assays and xenografts

    PMID:32677981

    Open questions at the time
    • How FTL connects mechanistically to AKT/GSK3β/β-catenin not defined
    • Single lab
  7. 2022 Medium

    An RNA-level control mechanism was added: NSUN5-mediated m5C methylation of FTL mRNA, recruited via TRAP1, maintains FTL protein and protects against ferroptosis.

    Evidence RNA immunoprecipitation, co-IP, knockdown/overexpression with ROS and lipid peroxidation readouts

    PMID:35249107

    Open questions at the time
    • The methylated cytosine position(s) on FTL mRNA not mapped
    • How m5C stabilizes or enhances translation of FTL not defined
  8. 2024 Medium

    Additional transcription factors (SPI1, GATA3) were established as direct FTL activators linking it to cancer metabolism and trophoblast function, and FTL was tied to iron-driven DNA repair and platinum resistance.

    Evidence ChIP and dual-luciferase for SPI1 and GATA3; iron supplementation/chelation experiments for the POLQ/RAD51 repair axis

    PMID:38740757 PMID:39675923 PMID:40421527

    Open questions at the time
    • The DNA-repair linkage is indirect, with no direct FTL-POLQ/RAD51 interaction shown
    • How multiple TFs are integrated on the FTL promoter not resolved
  9. 2025 Medium

    Post-translational control of FTL stability was defined through opposing acetylation and ubiquitination inputs, and FTL1 was shown to causally regulate neuronal aging through iron-oxidation-state effects on ATP synthesis.

    Evidence Co-IP/GST pulldown mapping SIRT1 deacetylation at K181; SCARA5 co-IP and ubiquitination assay; AAV neuronal FTL1 overexpression/knockdown with NADH rescue in mice

    PMID:39786573 PMID:40084377 PMID:40830655

    Open questions at the time
    • How K181 acetylation status is sensed by degradation machinery not defined
    • SCARA5-FTL finding rests on single Co-IP/knockdown
    • Molecular basis for altered iron oxidation state in neurons not established
  10. 2026 Medium

    HERC2 was identified as a direct E3 ubiquitin ligase for FTL, and loss-of-function across cardiomyocytes and chondrocytes confirmed FTL as a general protective factor whose depletion triggers ferroptosis and senescence.

    Evidence IP-MS, co-IP, ubiquitination assay, and HERC2-deficient mouse OA model; FTL1 knockdown with Ferrostatin-1 rescue in cardiomyocytes

    PMID:41854786 PMID:42177202

    Open questions at the time
    • HERC2 ubiquitination site(s) on FTL not mapped
    • Whether HERC2 and SIRT1/SCARA5 act on the same FTL pool not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the multiple converging regulatory layers—IRE translational control, mRNA m5C methylation, transcriptional activation/repression, and competing acetylation/ubiquitination—are integrated to set FTL levels in a tissue-specific manner remains unresolved.
  • No study reconciles transcriptional, translational, and post-translational FTL control in one system
  • Structural consequence of K181 modification and HERC2 ubiquitination on the ferritin shell unknown
  • Nuclear/spindle-associated functions of FTL mechanistically uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140313 molecular sequestering activity 3 GO:0098772 molecular function regulator activity 1
Localization
GO:0005634 nucleus 1 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-1643685 Disease 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-1430728 Metabolism 2
Partners
GADD45AHERC2NSUN5SCARA5SIRT1TRAP1
Complex memberships
ferritin

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 FTL protein localizes to the nucleus of GBM cells and associates with mitotic spindles. FTL physically interacts with GADD45A (confirmed by co-immunoprecipitation), and FTL knockdown activates the GADD45A/JNK pathway, inhibiting GBM cell growth. Co-transfection of FTL impedes GADD45A-induced reduction of cell viability. Immunofluorescence, co-immunoprecipitation, siRNA knockdown, immunoblotting, cell viability assays PloS one Medium 26871431
2014 The 498-499InsTC mutation in FTL substitutes the last 9 amino acids and extends the C-terminus by 16 amino acids. Cyclic voltammetry on the purified mutant protein showed this structural change severely reduces the ability of FTL to store iron. In transgenic FVB mice expressing this mutant, accumulation of mutated ferritin in brain correlated with increased iron deposition and oxidative damage with age, and progressive motor coordination deficits. Cyclic voltammetry on purified protein, transgenic mouse model (FVB and C57BL/6 backgrounds), MRI, rotarod behavioral testing, ultrastructural analysis Neurobiology of disease High 25447222
2022 NSUN5 binds FTL mRNA (shown by RNA immunoprecipitation) and methylates it at the 5-methylcytosine position; NSUN5 depletion reduces 5-methylcytosine levels on FTL RNA, lowers FTL protein, increases intracellular free iron, and leads to downregulation of GPX4 and accumulation of ROS and lipid peroxidation, promoting ferroptosis. Recognition of FTL by NSUN5 depends on recruitment of TRAP1 (shown by co-immunoprecipitation). RNA immunoprecipitation, co-immunoprecipitation, siRNA knockdown, overexpression, ROS/lipid peroxidation assays Cell death discovery Medium 35249107
2020 HIF-1α directly binds to the HRE-3 element in the FTL promoter to transcriptionally upregulate FTL expression under hypoxia (confirmed by luciferase reporter and ChIP assays). FTL knockdown represses EMT and reduces migration/invasion of glioma cells via the AKT/GSK3β/β-catenin signaling pathway. Luciferase reporter assay, chromatin immunoprecipitation (ChIP), siRNA knockdown, wound healing/transwell assays, western blot, subcutaneous xenograft model Journal of experimental & clinical cancer research : CR Medium 32677981
2007 A 25 bp deletion in the FTL promoter abolishing the transcription start site causes HHCS; in lymphoblastoid cells, the deletion allele is transcribed from an alternate start site within the lower stem of the iron-responsive element (IRE), and mutation carriers have high cellular L-ferritin levels, demonstrating that disruption of the transcription start site leads to de-repression of FTL translation. Sequencing of promoter/IRE region, lymphoblastoid cell transfection/expression analysis, genetic linkage in kindred Human mutation Medium 17579362
2006 A missense mutation in FTL (474G>A; A96T) causes neuroferritinopathy with early-onset bilateral pallidal involvement. Affected individuals and carrier showed abnormally low levels of serum ferritin, consistent with loss of FTL iron-storage function. Genetic sequencing, clinical biochemistry (serum ferritin), MRI Neurology Low 16116125
2006 Mutations in the IRE of FTL (c.-168G>A) cause hereditary hyperferritinemia cataract syndrome (HHCS) by disrupting the iron-responsive element in the 5'-UTR of FTL, leading to unregulated (constitutively high) FTL translation and elevated serum ferritin without iron overload. Genome-wide linkage analysis, sequencing of IRE region, hematological tests Molecular vision Medium 16518306
2025 SIRT1 deacetylates FTL at the K181 residue (confirmed by co-immunoprecipitation and GST pulldown), upregulating FTL expression. FTL knockdown inhibits the ferroptosis-suppressive effect of SIRT1 overexpression in chondrocytes. In vivo, SIRT1 overexpression reduced OA severity via this FTL deacetylation mechanism. Co-immunoprecipitation, GST pulldown, quantitative RT-PCR, western blotting, IL-1β and DMM mouse OA models, ferroptosis assays (LDH, Fe2+, GSH, MDA, lipid ROS) Journal of bone and mineral metabolism Medium 39786573
2026 HERC2 (a HECT-domain E3 ubiquitin ligase) directly interacts with FTL (validated by co-immunoprecipitation and ubiquitination assay) and promotes FTL ubiquitination and degradation, leading to intracellular iron accumulation, autophagy activation, lipid peroxidation, and chondrocyte ferroptosis in osteoarthritis. HERC2 deficiency in vivo preserved cartilage integrity. Immunoprecipitation-mass spectrometry, co-immunoprecipitation, ubiquitination assay, siRNA knockdown/overexpression, molecular docking, HERC2-deficient mouse DMM model Apoptosis : an international journal on programmed cell death Medium 41854786
2024 FTL (ferritin) tightly regulates labile iron levels, and elevated FTL promotes iron-dependent DNA damage repair in ovarian cancer: iron downregulates POLQ (a HR inhibitor) and relieves its antagonism of RAD51, thereby promoting DNA repair and platinum resistance. FTH1/FTL are indispensable for this iron-triggered DNA repair pathway. Iron supplementation/chelation experiments, western blot, cell survival/migration assays, in vitro and in vivo xenograft Cell death & disease Low 38740757
2025 Increasing neuronal FTL1 in the hippocampus of young mice alters labile iron oxidation states and promotes synaptic and cognitive features of hippocampal aging. Targeting (reducing) neuronal FTL1 in aged mouse hippocampi improves synaptic molecular changes and cognitive impairments. FTL1 knockdown-induced pro-aging effects are partially rescued by NADH supplementation, linking FTL1-mediated iron dysregulation to impaired ATP synthesis. Transcriptomics, mass spectrometry, AAV-mediated neuronal FTL1 overexpression/knockdown in mice, cognitive behavioral testing, neuronal nuclei RNA sequencing, NADH supplementation rescue Nature aging High 40830655
2025 SCARA5 protein physically interacts with FTL (confirmed by co-immunoprecipitation) and reduces FTL ubiquitination, thereby stabilizing FTL protein. SCARA5 upregulation promotes ferroptosis in colon cancer cells through FTL; siRNA knockdown of FTL attenuates the pro-ferroptotic effect of SCARA5. Co-immunoprecipitation, siRNA knockdown, ubiquitination assay, cell ferroptosis assays American journal of cancer research Low 40084377
2025 YY1 transcription factor binds the FTL promoter to repress its expression; YY1 knockdown alleviates FTL induction, ferroptosis, and pulmonary fibrosis caused by polystyrene nanoplastics. PS-NPs suppress GPX4 while inducing FTL, driving lipid peroxidation. Transcriptomic and proteomic profiling, in vitro BEAS-2B cell model, in vivo mouse aspiration model, YY1 promoter binding (implied ChIP), siRNA knockdown Materials today. Bio Low 41560817
2026 Knockdown of FTL1 in cardiomyocytes induces ferroptosis and cellular senescence, phenotypes reversed by the ferroptosis inhibitor Ferrostatin-1, establishing FTL1 as a protective factor against cardiac ferroptosis and aging. Region-resolved quantitative proteomics, siRNA knockdown, Ferrostatin-1 rescue, aging mouse model (3, 12, 20 months) Cell death & disease Medium 42177202
2024 GATA3 functions as an upstream transcription factor that directly regulates FTL expression: GATA3 knockdown reduces FTL levels while GATA3 overexpression increases them. Palmitic acid suppresses FTL by inhibiting GATA3 nuclear translocation, and AMPK activation rescues FTL expression and restores trophoblast function (confirmed by chromatin immunoprecipitation and dual-luciferase reporter assay). ChIP assay, dual-luciferase reporter assay, siRNA knockdown, overexpression, palmitic acid treatment, AMPK activator treatment, high-fat diet mouse model Hypertension (Dallas, Tex. : 1979) Medium 40421527
2024 SPI1 (Salmonella pathogenicity island 1 transcription factor) directly upregulates FTL expression to promote glycolysis and metastasis in ovarian cancer, validated by dual-luciferase assay and ChIP. Dual-luciferase assay, chromatin immunoprecipitation, qRT-PCR, western blot, transwell assay, glycolysis measurement (ECAR, OCR), xenograft mouse model Expert review of anticancer therapy Medium 39675923
2022 FTL knockdown in mesothelioma cells induces G1 cell cycle arrest accompanied by increased p21 and p27 and decreased CDK2 and phosphorylated Rb, demonstrating that FTL promotes cell cycle progression through G1 by modulating cyclin-CDK-Rb axis. siRNA knockdown, flow cytometry cell cycle analysis, western blot for p21, p27, CDK2, pRb Oncology letters Low 35497939
1997 The FTL gene was precisely mapped to human chromosome band 19q13.3 by fluorescence in situ hybridization (FISH). In situ fluorescence hybridization (FISH) Annales de genetique Medium 9526618

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation. Brain : a journal of neurology 143 17142829
2020 Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma. Journal of experimental & clinical cancer research : CR 128 32677981
2022 The NSUN5-FTH1/FTL pathway mediates ferroptosis in bone marrow-derived mesenchymal stem cells. Cell death discovery 94 35249107
2009 Transducin beta-like gene FTL1 is essential for pathogenesis in Fusarium graminearum. Eukaryotic cell 75 19377037
2005 Neuroferritinopathy: missense mutation in FTL causing early-onset bilateral pallidal involvement. Neurology 66 16116125
2016 Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway. PloS one 52 26871431
2020 Ferritin Light Chain (FTL) competes with long noncoding RNA Linc00467 for miR-133b binding site to regulate chemoresistance and metastasis of colorectal cancer. Carcinogenesis 41 31675755
2014 A novel neuroferritinopathy mouse model (FTL 498InsTC) shows progressive brain iron dysregulation, morphological signs of early neurodegeneration and motor coordination deficits. Neurobiology of disease 37 25447222
2010 The fslE homolog, FTL_0439 (fupA/B), mediates siderophore-dependent iron uptake in Francisella tularensis LVS. Infection and immunity 33 20696823
2024 Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis. Cell death & disease 30 38740757
2006 Sutural cataract associated with a mutation in the ferritin light chain gene (FTL) in a family of Indian origin. Molecular vision 29 16518306
2015 Hereditary hemochromatosis type 1 phenotype modifiers in Italian patients. The controversial role of variants in HAMP, BMP2, FTL and SLC40A1 genes. Blood cells, molecules & diseases 25 25976471
2022 Integrated Analysis Reveals Critical Ferroptosis Regulators and FTL Contribute to Cancer Progression in Hepatocellular Carcinoma. Frontiers in genetics 23 35651950
2018 Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons. Journal of neuropathology and experimental neurology 22 29186589
2006 Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype. Journal of human genetics 22 16858508
2007 A novel deletion in the FTL gene causes hereditary hyperferritinemia cataract syndrome (HHCS) by alteration of the transcription start site. Human mutation 16 17579362
2017 FTL: a novel predictor in gastric cancer. International journal of clinical and experimental pathology 13 31966634
2015 Inner retinal change in a novel rd1-FTL mouse model of retinal degeneration. Frontiers in cellular neuroscience 13 26283925
2014 FTT0831c/FTL_0325 contributes to Francisella tularensis cell division, maintenance of cell shape, and structural integrity. Infection and immunity 12 24778115
2022 Downregulation of FTL decreases proliferation of malignant mesothelioma cells by inducing G1 cell cycle arrest. Oncology letters 9 35497939
2018 FTL c.-168G>C Mutation in Hereditary Hyperferritinemia Cataract Syndrome: A New Italian Family. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 9 29426274
2016 FTL mutation in a Chinese pedigree with neuroferritinopathy. Neurology. Genetics 9 27158664
2009 [Expression of FTL and FTH genes encoding ferretin subunits in lung and renal carcinomas]. Molekuliarnaia biologiia 8 20088381
2025 Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment. Nature aging 7 40830655
2009 Mapping retinal degeneration and loss-of-function in Rd-FTL mice. Investigative ophthalmology & visual science 7 19661224
2024 A QTL GN1.1, encoding FT-L1, regulates grain number and yield by modulating polar auxin transport in rice. Journal of integrative plant biology 6 39083298
2024 Carvedilol Confers Ferroptosis Resistance in HL-1 Cells by Upregulating GPX4, FTH1, and FTL1 and Inducing Metabolic Remodeling Under Hypoxia/Reoxygenation. Antioxidants (Basel, Switzerland) 6 39857341
2001 The relationship between FTL and NA, DMV or CVLM in central cardiovascular control. The Chinese journal of physiology 6 11908546
2024 Iron-induced kidney cell damage: insights into molecular mechanisms and potential diagnostic significance of urinary FTL. Frontiers in molecular biosciences 5 38449697
2007 [Hereditary hyperferritinemia cataracts syndrome in a Spanish family caused by the A40G mutation (Paris) in the L-ferritin (FTL) gene associated with the mutation H63D in the HFE gene]. Medicina clinica 5 17927936
1997 Assignment of ferritin L gene (FTL) to human chromosome band 19q13.3 by in situ hybridization. Annales de genetique 5 9526618
2025 Sirt1 overexpression inhibits chondrocyte ferroptosis via Ftl deacetylation to suppress the development of osteoarthritis. Journal of bone and mineral metabolism 4 39786573
2011 [Hyperferritinemia, ferropenia and metabolic syndrome in a patient with a new mutation of gene TFR2 and another in gene FTL. A family study]. Medicina clinica 3 21524769
2026 Single-nucleus and machine-learning integration identifies HLA-DRA and FTL as immune-metabolic axes and traditional Chinese medicine-targetable hubs in calcific aortic valve disease. Journal of computer-aided molecular design 2 41721874
2025 Hyperlipidemia Triggers Trophoblast Cell Dysfunction and Preeclampsia via the AMPK/GATA3/FTL Pathway. Hypertension (Dallas, Tex. : 1979) 2 40421527
2018 Frequent Mutation in the FTL Gene Causing Hyperferritinemia Cataract Syndrome in Turkish Population Is c.-160A>G. Turkish journal of haematology : official journal of Turkish Society of Haematology 2 30401656
2025 SCARA5 might be one potential marker for CC and promoted Ferroptosis by FTL. American journal of cancer research 1 40084377
2024 Activation of ferritin light chain (FTL) by transcription factor salmonella pathogenicity island 1 modulates glycolysis to drive metastasis of ovarian cancer cells. Expert review of anticancer therapy 1 39675923
2026 Disruption of iron homeostasis by HERC2-FTL axis leads to chondrocyte loss and exacerbates osteoarthritis. Apoptosis : an international journal on programmed cell death 0 41854786
2026 Multi-region proteomic mapping identifies FTL1 and SERPINA3K as protective factors in cardiac aging. Cell death & disease 0 42177202
2025 Species-Specific Isotope Dilution Methodology for the SI Traceable Quantification of Serum Human Ferritin Light Chain (FTL). Analytical chemistry 0 41230879
2025 Targeting FTL regulates ferroptosis and remodels lymph node metastasis microenvironment in esophageal squamous cell carcinoma. International journal of biological sciences 0 41281761
2025 Polystyrene nanoplastics-induced lung epithelial cells ferroptosis promotes pulmonary fibrosis via YY1/FTL axis. Materials today. Bio 0 41560817
2021 A 3'-truncating FTL mutation associated with hypoferritinemia without neuroferritinopathy. European journal of medical genetics 0 33548513

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