Affinage

FOXI1

Forkhead box protein I1 · UniProt Q12951

Length
378 aa
Mass
41.0 kDa
Annotated
2026-04-28
39 papers in source corpus 20 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FOXI1 is a forkhead-family transcription factor that serves as a master regulator of proton-secreting ionocyte/intercalated cell identity across multiple epithelia including the kidney collecting duct, inner ear endolymphatic sac, and epididymis. It directly binds and activates the promoters of vacuolar H⁺-ATPase subunits (ATP6V1B1, ATP6V0A4), pendrin (SLC26A4), carbonic anhydrase II, and the Cl⁻/HCO₃⁻ exchanger AE4 (SLC4A9), and its loss collapses the normal two-cell-type collecting duct epithelium into a single hybrid cell type, causing distal renal tubular acidosis and, in the inner ear, deafness resembling Pendred syndrome (PMID:15173882, PMID:12642503, PMID:19214237, PMID:16159312). In development, FOXI1 acts downstream of BMP signaling and upstream of Pax8 to confer otic placode competence and epibranchial neuronal specification, and exhibits concentration-dependent roles in maintaining ectodermal progenitor competence versus driving ionocyte differentiation (PMID:12538519, PMID:15459102, PMID:17239227, PMID:41490055). Loss-of-function mutations in the FOXI1 DNA-binding domain cause syndromic sensorineural deafness with distal renal tubular acidosis in humans (PMID:29242249).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2003 High

    Establishing FOXI1 as an essential upstream competence factor for otic and epibranchial placode specification resolved how pre-placodal ectoderm acquires responsiveness to Fgf induction signals.

    Evidence Forward genetic screen and epistasis in zebrafish foxi1 mutants showing loss of pax8 in otic precursors and failure of neurogenin/phox2a expression in epibranchial placodes; gain-of-function rescued neuronal specification

    PMID:12538519 PMID:12736211

    Open questions at the time
    • Direct transcriptional targets mediating otic competence not identified at this stage
    • Mechanism of foxi1 activation in pre-placodal ectoderm unknown
  2. 2003 High

    Demonstration that Foxi1 is required for pendrin expression in the endolymphatic duct established the first link between FOXI1 and inner ear ion homeostasis, explaining the deafness phenotype.

    Evidence Foxi1 knockout mice lack pendrin transcript in endolymphatic duct/sac with expanded membranous labyrinth and deafness

    PMID:12642503

    Open questions at the time
    • Whether Foxi1 directly binds the pendrin promoter was not tested
    • Whether human FOXI1 mutations cause deafness was unknown
  3. 2004 High

    Discovery that Foxi1 loss abolishes intercalated cell differentiation in the kidney, replacing the two-cell epithelium with a hybrid cell type, established FOXI1 as the master switch for renal intercalated cell identity and acid–base homeostasis.

    Evidence Foxi1 knockout mice develop dRTA; Northern blot, immunohistochemistry, and electron microscopy show complete loss of intercalated cell markers and gain of principal cell markers in a single hybrid cell type

    PMID:15173882

    Open questions at the time
    • Direct promoter binding to renal target genes not yet demonstrated
    • Mechanism of cell-fate decision (Foxi1 ON vs OFF) in collecting duct progenitors unresolved
  4. 2004 High

    Epistasis experiments placing Foxi1 and Dlx3b as parallel, independent competence factors for otic induction clarified that neither alone is sufficient and that combined loss eliminates all otic fate even with intact Fgf.

    Evidence Double morpholino knockdown of foxi1 and dlx3b in zebrafish abolishes otic specification

    PMID:15459102

    Open questions at the time
    • How Foxi1 and Dlx3b are independently activated was unresolved
    • Whether this parallel architecture is conserved in mammals was untested
  5. 2006 High

    Identification of direct FOXI1 binding sites in the ATP6V1B1, SLC4A9, and SLC26A4 promoters through EMSA, mutagenesis, and reporter assays established the molecular mechanism by which FOXI1 activates ion transport gene expression.

    Evidence Recombinant Foxi1 binds specific cis-elements in AE4/Slc4a9 and ATP6V1B1 promoters; mutation of sites abolishes binding and transcriptional activation; Foxi1-null male mice are infertile due to loss of epididymal proton secretion

    PMID:16159312 PMID:16932748

    Open questions at the time
    • Genome-wide binding profile of FOXI1 in relevant tissues not yet obtained
    • Cofactors that cooperate with FOXI1 at target promoters not identified
  6. 2006 High

    The unexpected finding that FOXI1 remains bound to mitotic chromosomes and remodels chromatin structure revealed a potential bookmarking mechanism for maintaining intercalated cell identity through cell division.

    Evidence Live-cell imaging, ChIP, DNase I hypersensitivity, and MNase digestion in inducible cell lines showed FOXI1 association with condensed chromosomes and stable chromatin remodeling

    PMID:16354687

    Open questions at the time
    • Whether mitotic bookmarking is functionally required for intercalated cell maintenance in vivo is untested
    • Identity of bookmarked loci in intercalated cells unknown
  7. 2007 Medium

    Placing FOXI1 downstream of BMP signaling and upstream of Fgf-responsiveness completed the signaling hierarchy for otic placode induction.

    Evidence BMP manipulation in zebrafish shows BMP activates foxi1 expression; foxi1/dlx3b provide competence for Fgf-mediated otic induction

    PMID:17239227

    Open questions at the time
    • Whether BMP directly activates the foxi1 promoter was not tested
    • Whether this hierarchy operates identically in mammals is unknown
  8. 2009 High

    ChIP and mutagenesis demonstrating direct FOXI1 binding to the ATP6V0A4 (a4-subunit) promoter extended the catalogue of directly regulated V-ATPase subunit genes across kidney, ear, and epididymis.

    Evidence ChIP, EMSA, site-directed mutagenesis, and promoter-reporter assays identify a critical Foxi1 cis-element at −561/−547 in the a4 promoter

    PMID:19214237

    Open questions at the time
    • Whether all V-ATPase subunit genes are direct targets remains unresolved
    • Tissue-specific cofactor requirements for target gene selectivity unknown
  9. 2017 Medium

    Identification of loss-of-function FOXI1 mutations in patients with syndromic deafness and dRTA validated the mouse model findings in human disease and confirmed FOXI1 as a Mendelian disease gene.

    Evidence Homozygous missense mutations (L146F, R213P) in the FOXI1 DNA-binding domain found in patients; functional assays show reduced DNA-binding affinity

    PMID:29242249

    Open questions at the time
    • Only two mutations characterized; full allelic spectrum unknown
    • No patient renal biopsy confirming intercalated cell loss
  10. 2021 High

    Genetic epistasis showing that Foxi1 deletion completely prevents cystogenesis in Tsc1 knockout mice revealed an unexpected role for FOXI1 in driving pathological cyst formation via A-intercalated cell hyperproliferation in tuberous sclerosis.

    Evidence Tsc1/Foxi1 double KO mice lack renal cysts by MRI, histology, and RNA-seq, while Tsc1 single KO mice develop progressive cysts; replicated in Tsc1/Car2 dKO comparison

    PMID:33536341 PMID:38731991

    Open questions at the time
    • Mechanism by which mTOR activation upregulates Foxi1 is unknown
    • Whether FOXI1 inhibition could be therapeutic for TSC cysts is untested in pharmacological models
  11. 2024 Medium

    Demonstration that Foxi1 has concentration-dependent functions — maintaining progenitor competence at low levels and driving ionocyte differentiation at high levels — provided a unified model for how a single transcription factor controls both stemness and terminal differentiation.

    Evidence Gain- and loss-of-function in Xenopus mucociliary epidermis with transcriptomic and epigenetic assays; autoregulation and Notch-mediated regulation shown

    PMID:41490055

    Open questions at the time
    • Whether dose-dependent function is conserved in mammalian kidney intercalated cell specification is unconfirmed
    • Epigenetic targets mediating low-level competence function not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the genome-wide direct target repertoire of FOXI1 in intercalated cells, the cofactors and chromatin regulators that cooperate with FOXI1 to establish ionocyte identity, the upstream signals that activate FOXI1 in mammalian kidney progenitors, and whether FOXI1's mitotic bookmarking activity is functionally required for intercalated cell maintenance.
  • No genome-wide ChIP-seq in primary intercalated cells
  • Cofactors and chromatin remodelers cooperating with FOXI1 at target loci unidentified
  • Upstream signaling pathway activating FOXI1 in mammalian collecting duct unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 7 GO:0003677 DNA binding 4
Localization
GO:0005634 nucleus 2 GO:0005694 chromosome 1
Pathway
R-HSA-1266738 Developmental Biology 8 R-HSA-382551 Transport of small molecules 4 R-HSA-1643685 Disease 3
Partners
ATP6V0A4ATP6V1B1DLX3BDMRT2PAX8SLC26A4SLC4A9UBP1

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 Foxi1 knockout mice develop distal renal tubular acidosis (dRTA) due to loss of intercalated cell identity in the collecting duct; Foxi1-null mice show complete loss of expression of anion transporters, proton pumps, and anion exchange proteins in intercalated cells, and the normal two-cell-type epithelium is replaced by a single hybrid cell type positive for both principal and intercalated cell markers, demonstrating that Foxi1 is required for intercalated cell differentiation and gene expression. Knockout mouse model, Northern blot, cRNA in situ hybridization, immunohistochemistry, electron microscopy, acid-load functional assay The Journal of clinical investigation High 15173882
2003 Foxi1 is required upstream of pendrin (PDS/SLC26A4) in the endolymphatic duct/sac epithelium; Foxi1-null mice completely lack pendrin transcript in this epithelium, leading to expansion of the membranous labyrinth and deafness resembling Pendred syndrome. Foxi1 marks a specific cell type (FORE cells) co-expressing Pds, Coch and Jag1. Knockout mouse model, in situ hybridization, paint-fill experiments, histology, 3D reconstruction Development (Cambridge, England) High 12642503
2003 Zebrafish foxi1 is required for otic placode initiation and regulates expression of pax8 in otic precursor cells, placing foxi1 upstream of pax8 in the otic specification pathway. foxi1 is also expressed in developing branchial arches and required for jaw formation. Forward genetic screen (hearsay/foxi1 mutant), epistasis, whole-mount in situ hybridization, genetic rescue Development (Cambridge, England) High 12538519
2009 Foxi1 directly trans-activates the vacuolar H+-ATPase a4-subunit promoter; co-localization of Foxi1 with V-ATPase subunits A1, B1, E2 and a4 in inner ear FORE cells, renal intercalated cells, and epididymal narrow/clear cells was demonstrated, and promoter reporter assays, EMSA, site-directed mutagenesis and ChIP identified a critical Foxi1 binding cis-element at position -561/-547 in the a4 promoter required for activation. Promoter-reporter assay, EMSA, ChIP, site-directed mutagenesis, immunofluorescence co-localization, KO mouse PloS one High 19214237
2004 In zebrafish, Foxi1 and Dlx3b act as independent upstream regulators providing competence for otic specification: Foxi1 regulates pax8 expression while Dlx3b regulates pax2a expression, and combined loss of both eliminates all otic specification even with intact Fgf signaling. Genetic epistasis (double morpholino knockdown), in situ hybridization in zebrafish Development (Cambridge, England) High 15459102
2006 Foxi1 directly binds and activates the ATP6V1B1 (V-ATPase B1-subunit) promoter and regulates expression of carbonic anhydrase II and pendrin in epididymal narrow and clear cells; Foxi1-null males are infertile due to defective epididymal proton secretion and failed sperm maturation. A specific Foxi1 binding cis-element in the ATP6V1B1 promoter was identified by transfection and mutation analysis. Knockout mouse model, transfection reporter assay, site-directed mutagenesis, fertility assay The EMBO journal High 16932748
2006 FoxI1 remains bound to condensed mitotic chromosomes during mitosis (unlike most transcription factors) and stably remodels chromatin higher-order structure, creating or removing DNase I hypersensitive sites; ChIP revealed that 88% of FoxI1-bound sequences contain consensus Fox binding sites, and MNase digestion showed that FoxI1 generally increases nucleosome compaction. Stable inducible GFP/V5-tagged cell line, ChIP, quantitative DNase I hypersensitivity assay, MNase partial digestion, live-cell imaging Molecular and cellular biology High 16354687
2006 Foxi1 directly activates the AE4 (Slc4a9) promoter via a single specific binding site ~462 bp upstream of the transcription start; recombinant Foxi1 protein binds this element in bandshift (EMSA) assays, and mutation of this site abolishes both binding and transcriptional activation, demonstrating direct transcriptional regulation of the type B intercalated cell chloride/bicarbonate exchanger. Promoter-reporter transfection assay, EMSA with recombinant protein, site-directed mutagenesis, 5'-truncation analysis The Biochemical journal High 16159312
2007 Foxi1 (and Dlx3b) provide Fgf-responsiveness competence for otic induction; BMP signaling (not Fgf signaling) directly activates foxi1 expression, placing Foxi1 downstream of BMP and upstream of the Fgf response in otic placode induction. Transgenic Fgf8 misexpression (hsp70 promoter), pharmacological Fgf inhibition, BMP pathway manipulation, in situ hybridization in zebrafish BMC developmental biology Medium 17239227
2003 Zebrafish Foxi1 is required for epibranchial placode-derived sensory neuron specification; in foxi1 (no soul) mutants, placodal progenitors fail to express neurogenin and phox2a, undergo apoptosis, and ectopic foxi1 expression is sufficient to induce neurogenin- and phox2a-positive cells. Forward genetic screen, in situ hybridization, TUNEL apoptosis assay, mRNA misexpression (gain-of-function) in zebrafish Development (Cambridge, England) High 12736211
2011 Pax2/8 proteins downregulate otic foxi1 expression as a necessary step for further otic development, and activate fgf24 in the otic placode, which in turn induces epibranchial sox3; this establishes a sequential induction mechanism where the otic placode forms first and induces epibranchial placodes through an Fgf-relay. Morpholino knockdown epistasis, in situ hybridization in zebrafish Developmental biology Medium 21215261
2013 In zebrafish, Foxi1 provides neuronal (but not sensory hair cell) competence during otic-epibranchial progenitor domain (OEPD) induction: loss of Foxi1 prevents neuronal precursor formation without affecting hair cell specification, while loss of Dlx3b/4b inhibits hair cell but not neuronal precursor formation, demonstrating sequential and distinct competence roles. Genetic lineage tracing (PioTrack Cre-dependent method), mutant analysis, in situ hybridization in zebrafish Development (Cambridge, England) Medium 23571216
2017 Missense mutations in the FOXI1 DNA-binding domain (p.L146F and p.R213P) found in patients with sensorineural deafness and distal renal tubular acidosis reduce FOXI1 DNA-binding affinity in cultured cells, causing failure to adequately activate target genes crucial for inner ear function and renal acid-base regulation. Human genetics (homozygous patient mutations), functional cell-based assay of DNA binding affinity Journal of the American Society of Nephrology : JASN Medium 29242249
2021 Foxi1 drives cystogenesis in tuberous sclerosis complex (TSC): deletion of Foxi1 in Tsc1 KO mice completely abrogates renal cyst burden, while Foxi1 and its downstream targets H+-ATPase, CAII, and CLC-5 are robustly expressed in cyst epithelia composed of hyperproliferating A-intercalated cells. Double knockout mouse model (Foxi1/Tsc1 dKO), MRI, histology, RNA-seq, immunolocalization Proceedings of the National Academy of Sciences of the United States of America High 33536341
2017 FOXI1 binds the miR-491-5p promoter and activates its expression in gastric cancer cells, as demonstrated by bioinformatic analysis and luciferase reporter assays, placing FOXI1 upstream of a miRNA-mediated tumor suppressor pathway targeting Wnt3a/β-catenin. Luciferase reporter assay, bioinformatic analysis, overexpression/knockdown in gastric cancer cell lines Cell death & disease Low 28358374
2021 FOXI1 overexpression in gastric cancer cells activates miR-590 expression by binding its promoter (validated by ChIP-qPCR and luciferase reporter), which then suppresses ATF3 protein expression, inhibiting gastric cancer cell proliferation. ChIP-seq, RNA-seq, ChIP-qPCR, dual-luciferase reporter assay, overexpression experiments Progress in biophysics and molecular biology Medium 33610681
2018 In zebrafish, ectodermal Foxi1 acts downstream of Fgf8a during late-stage pharyngeal pouch morphogenesis to promote rearrangement of pouch-forming cells into bilayers; foxi1 activates wnt4a expression in facial ectoderm (foxi1 and wnt4a are co-expressed, wnt4a expression is abolished in foxi1 mutants but foxi1 is unaffected in wnt4a mutants), and foxi1 mutant pouch defects resemble those of wnt4a mutants. Zebrafish mutant analysis, in situ hybridization, epistasis by comparing foxi1 and wnt4a mutant phenotypes Developmental biology Medium 29932895
2023 Overexpression of Foxi1 in M-1 murine cortical collecting duct cells is sufficient to induce intercalated cell transcripts including Gpr116, Atp6v1b1, Atp6v1g3, Atp6v0d2, Slc4a9, and Slc26a4, demonstrating that Foxi1 alone can shift principal cell identity toward an intercalated cell phenotype. Transfection/overexpression in M-1 cell line, RT-PCR/transcriptomic profiling American journal of physiology. Renal physiology Medium 36603001
2024 Foxi1 has concentration-dependent functions in Xenopus mucociliary epidermis: at low levels it maintains ectodermal competence in multipotent progenitors through transcriptional and epigenetic mechanisms, while at high levels it drives ionocyte specification and differentiation in cooperation with Ubp1 and Dmrt2; foxi1 expression is subject to auto-regulation and Notch-mediated regulation. Gain- and loss-of-function experiments in Xenopus laevis, transcriptomic analysis, epigenetic assays PLoS biology Medium 41490055
2024 Foxi1 deletion completely abrogates kidney cyst formation in Tsc1 KO mice even at advanced age, whereas Car2 deletion only transiently reduces cysts; enhanced Foxi1 expression in Tsc1/Car2 dKO mice correlates with progressive cyst burden, demonstrating that Foxi1 is epistatic to Car2 in TSC cystogenesis and is the essential driver. Double knockout mouse models (Tsc1/Car2 dKO vs Tsc1/Foxi1 dKO), MRI, histology, RNA-seq International journal of molecular sciences High 38731991

Source papers

Stage 0 corpus · 39 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. The Journal of clinical investigation 165 15173882
2003 Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development (Cambridge, England) 151 12642503
2003 Zebrafish foxi1 mediates otic placode formation and jaw development. Development (Cambridge, England) 141 12538519
2009 The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis. PloS one 109 19214237
2004 Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. Development (Cambridge, England) 107 15459102
2006 Epididymal expression of the forkhead transcription factor Foxi1 is required for male fertility. The EMBO journal 101 16932748
2017 Acidosis and Deafness in Patients with Recessive Mutations in FOXI1. Journal of the American Society of Nephrology : JASN 81 29242249
2006 The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure. Molecular and cellular biology 74 16354687
2007 Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC developmental biology 71 17239227
1995 Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12). Genomics 65 8825632
2017 miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer. Cell death & disease 61 28358374
2009 Phenotypic analyses and mutation screening of the SLC26A4 and FOXI1 genes in 101 Taiwanese families with bilateral nonsyndromic enlarged vestibular aqueduct (DFNB4) or Pendred syndrome. Audiology & neuro-otology 61 19648736
2021 Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 47 34531523
2003 The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons. Development (Cambridge, England) 45 12736211
2010 Screening of SLC26A4, FOXI1 and KCNJ10 genes in unilateral hearing impairment with ipsilateral enlarged vestibular aqueduct. International journal of pediatric otorhinolaryngology 42 20621367
2011 Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24. Developmental biology 39 21215261
2013 Lack of significant association between mutations of KCNJ10 or FOXI1 and SLC26A4 mutations in Pendred syndrome/enlarged vestibular aqueducts. BMC medical genetics 36 23965030
2006 The forkhead transcription factor Foxi1 directly activates the AE4 promoter. The Biochemical journal 32 16159312
2020 FOXI1 expression in chromophobe renal cell carcinoma and renal oncocytoma: a study of The Cancer Genome Atlas transcriptome-based outlier mining and immunohistochemistry. Virchows Archiv : an international journal of pathology 31 32812119
2012 Screening of SLC26A4, FOXI1, KCNJ10, and GJB2 in bilateral deafness patients with inner ear malformation. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 28 22412181
2014 Mutation analysis of the SLC26A4, FOXI1 and KCNJ10 genes in individuals with congenital hearing loss. PeerJ 26 24860705
2021 Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex. Proceedings of the National Academy of Sciences of the United States of America 22 33536341
2013 Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage. Development (Cambridge, England) 21 23571216
2023 Low-grade oncocytic tumour (LOT) of the kidney is characterised by GATA3 positivity, FOXI1 negativity and mTOR pathway mutations. Pathology oncology research : POR 19 36816543
2018 Foxi1 promotes late-stage pharyngeal pouch morphogenesis through ectodermal Wnt4a activation. Developmental biology 10 29932895
2022 Analysis of SLC26A4, FOXI1, and KCNJ10 Gene Variants in Patients with Incomplete Partition of the Cochlea and Enlarged Vestibular Aqueduct (EVA) Anomalies. International journal of molecular sciences 9 36499699
2023 The transcription factor Foxi1 promotes expression of V-ATPase and Gpr116 in M-1 cells. American journal of physiology. Renal physiology 8 36603001
2019 FOXI1 Immunohistochemistry Differentiates Benign Renal Oncocytoma from Malignant Chromophobe Renal Cell Carcinoma. Anticancer research 8 31177114
2021 FOXI1 inhibits gastric cancer cell proliferation by activating miR-590/ATF3 axis via integrating ChIP-seq and RNA-seq data. Progress in biophysics and molecular biology 6 33610681
2019 Analysis of mutations in the FOXI1 and KCNJ10 genes in infants with a single-allele SLC26A4 mutation. Bioscience trends 5 31243244
2024 Expression of FOXI1 and POU2F3 varies among different salivary gland neoplasms and is higher in Warthin tumor. Discover oncology 4 38358561
2022 Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis. Ecotoxicology and environmental safety 4 35998475
2010 African signatures of recent positive selection in human FOXI1. BMC evolutionary biology 4 20809947
2022 [Diagnosis of a Chinese pedigree affected with autosomal recessive deafness 4 with enlarged vestibular aqueduct due to compound heterozygous variants of FOXI1 gene]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2 36184087
2024 Carbonic Anhydrase 2 Deletion Delays the Growth of Kidney Cysts Whereas Foxi1 Deletion Completely Abrogates Cystogenesis in TSC. International journal of molecular sciences 1 38731991
2026 Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanisms. PLoS biology 0 41490055
2025 Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanisms. bioRxiv : the preprint server for biology 0 39484493
2025 Whole exome sequencing identified mutations of forkhead box I 1 (FOXI1), keratin 6 C (KRT6C) and gap junction protein delta 2 (GJD2) in a low-grade oncocytic tumor of the kidney: a case report. Diagnostic pathology 0 39980061
2023 Homozygous Missense Variants in FOXI1 and TMPRSS3 Genes Associated with Non-syndromic Deafness in Moroccan Families. Biochemical genetics 0 37777971