- Length
- 4061 aa
- Mass
- 435.2 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
16 papers cited in narrative
15 extracted findings
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
Insufficient on-target evidence to synthesize a narrative — discovery timeline does not match the canonical FLG protein.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Evidence
Reading pass · 15 per-paper findings extracted from the source corpus
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 2009 | A homozygous 1-bp deletion (5303delA) in the murine Flg gene (analogous to human FLG null mutations) causes epidermal barrier deficiency; topical allergen application to these mice produces cutaneous inflammatory infiltrates and enhanced allergen-specific IgE responses, establishing that antigen transfer through a defective filaggrin-deficient epidermal barrier is a key mechanistic step in cutaneous sensitization. | Mouse genetics (spontaneous Flg mutant), topical allergen challenge, histology, allergen-specific antibody measurement | Nature genetics | High | 19349982 |
| 2009 | The C-terminal region of filaggrin is essential for proper processing of profilaggrin into mature filaggrin peptides; FLG nonsense mutations located in C-terminal imperfect repeats (e.g., p.Lys4021X) cause remarkable reduction of filaggrin protein in the epidermis, demonstrating that no FLG mutation location shows genotype-phenotype correlation because all impair profilaggrin processing. | Comprehensive FLG sequencing, immunohistochemical staining of profilaggrin/filaggrin in patient epidermis, real-time RT-PCR | The British journal of dermatology | Medium | 19663875 19958351 |
| 2016 | FLG loss-of-function mutations in atopic dermatitis keratinocytes lead to increased arachidonic acid and 12-lipoxygenase metabolites (12-HETE) in human epidermal equivalents; exogenous arachidonic acid increases inflammatory cytokine expression in control keratinocytes, while 12-HETE attenuates late epidermal differentiation markers, establishing an autocrine eicosanoid mechanism by which FLG mutations trigger both inflammation and impaired differentiation. | Human epidermal equivalents from patient keratinocytes, lipidomic analysis, cytokine measurement, exogenous lipid mediator treatment | The Journal of investigative dermatology | Medium | 27793761 |
| 2011 | FLG knockdown in human keratinocytes assembled into 3D skin models causes impaired epidermal differentiation (histopathological changes), increased LDH leakage and IL-6/IL-8 release upon SDS irritation, and increased percutaneous absorption of lipophilic drugs, demonstrating that filaggrin deficiency directly causes barrier dysfunction and heightened susceptibility to irritants. | siRNA knockdown, 3D organotypic skin model, histopathology, cytokine ELISA, percutaneous absorption assay | Alternatives to laboratory animals : ATLA | Medium | 22103940 |
| 2018 | Rhodiola crenulata root extract upregulates FLG and loricrin (LOR) expression in keratinocytes through AHR activation in an OVOL1-dependent manner, while involucrin (IVL) upregulation is AHR-dependent but OVOL1-independent, defining an AHR→OVOL1→FLG regulatory axis for skin barrier gene expression. | AHR and OVOL1 siRNA knockdown, qRT-PCR, keratinocyte culture with Rhodiola extract | International journal of molecular sciences | Medium | 29866992 |
| 2019 | IL-13 downregulates the OVOL1-FLG axis in keratinocytes (and upregulates the periostin-IL-24 axis), establishing that the dominant Th2 cytokine in atopic dermatitis lesional skin mechanistically suppresses filaggrin expression through OVOL1. | Keratinocyte cytokine treatment, gene expression analysis, GWAS integration | Immunology | Medium | 31509236 |
| 2020 | Granzyme B (GzmB), elevated in atopic dermatitis, proteolytically cleaves filaggrin (FLG) and E-cadherin extracellularly, directly impairing epidermal barrier function; GzmB-/- mice show significantly reduced inflammation, epidermal thickening, and lesion formation in an oxazolone dermatitis model, and a small-molecule GzmB inhibitor reduces disease severity. | GzmB knockout mice, oxazolone model, topical GzmB inhibitor, in vitro cleavage assay | The Journal of investigative dermatology | High | 32504614 |
| 2021 | IL-4 and IL-13 induce nuclear accumulation of full-length IL-33 in keratinocytes via MAPK/ERK signaling; nuclear IL-33 acts as a transcription cofactor of phosphorylated STAT3, increasing pSTAT3 binding to the FLG promoter and thereby inhibiting FLG transcription; the nuclear IL-33/pSTAT3 complex also reduces RUNX1 expression, downregulating loricrin, keratin 1, and keratin 10. | Monolayer keratinocyte culture, living skin equivalents, MAPK/ERK inhibitors, ChIP (pSTAT3 binding to FLG promoter), co-immunoprecipitation, siRNA knockdown | The Journal of investigative dermatology | High | 33865911 |
| 2021 | IL-31 similarly increases nuclear full-length IL-33 and pSTAT3 in keratinocytes; the nuclear IL-33/pSTAT3 complex binds the FLG promoter to inhibit FLG transcription and reduces RUNX1 to downregulate keratin 1 and keratin 10, revealing a shared mechanism by which multiple Th2/pruritic cytokines converge on nuclear IL-33 to suppress filaggrin and epidermal differentiation. | Monolayer keratinocyte culture, living skin equivalents, ChIP, Co-IP, siRNA knockdown | The Journal of investigative dermatology | High | 34293350 |
| 2017 | GATA3 is a transcriptional regulator of filaggrin expression in keratinocytes: GATA3 knockdown by shRNA significantly reduces FLG and FLG2 mRNA under atopic dermatitis-like conditions, while GATA3 overexpression restores and upregulates FLG and FLG2 expression. | shRNA knockdown, overexpression, qRT-PCR in keratinocytes; immunohistochemistry in patient skin biopsies | Scientific reports | Medium | 28928464 |
| 2023 | CRISPR/Cas9 knockout of FLG in human N/TERT-2G keratinocytes causes loss of keratohyalin granules, reduction of multiple structural proteins (involucrin, hornerin, keratin 2, transglutaminase 1), denser stratum corneum lacking basket-weave architecture, and compromised epidermal barrier (increased TEWL, altered impedance); correction of FLG reinstates all these features, establishing that filaggrin is causally required for normal epidermal differentiation and orchestrates expression of other epidermal structural proteins. | CRISPR/Cas9 knockout, human epidermal equivalents, immunohistochemistry, TEWL measurement, electrical impedance spectroscopy, FLG re-expression rescue | The Journal of investigative dermatology | High | 36893939 |
| 2022 | FLG-deficient neonatal mice show increased epidermal dye penetration and elevated skin CD4+ T cells; commensal bacteria (S. epidermidis)-specific CD4+ T cells are skewed toward effector rather than regulatory T cells in Flg-/- pups, and this Th17-biased response persists into adulthood, causing increased susceptibility to imiquimod-induced skin inflammation, establishing a mechanism by which FLG deficiency in neonatal skin shapes the long-term commensal-specific immune response. | Flg-/- mouse model (C57BL/6), single-cell RNA sequencing, flow cytometry, engineered S. epidermidis 2W colonization, imiquimod challenge | The Journal of investigative dermatology | High | 36496196 |
| 2021 | FLG-deficient mice on pure BALB/c background (generated by CRISPR targeting) develop ichthyosis and a barrier defect with facilitated percutaneous sensitization but do NOT spontaneously develop dermatitis or systemic atopy; whole-genome sequencing revealed that previously reported atopy in Flgft/ft BALB/c mice was caused by a co-segregating homozygous Tmem79matted mutation, demonstrating that FLG deficiency alone lowers the sensitization threshold but does not cause atopy. | CRISPR/Cas9 Flg knockout on BALB/c background, whole-genome sequencing, TEWL measurement, IgE assay, percutaneous sensitization | The Journal of investigative dermatology | High | 33894197 |
| 2024 | GSDMD (gasdermin D), activated by Caspase-1, inhibits FLG expression by stabilizing HDAC1: GSDMD blocks the interaction between KCTD6 (an E3 ligase adaptor) and HDAC1, preventing HDAC1 ubiquitin-mediated degradation; accumulated HDAC1 then reduces histone acetylation at the FLG promoter, repressing FLG transcription. This GSDMD→HDAC1→FLG axis links pyroptosis activation to epidermal barrier dysfunction in atopic dermatitis. | Co-immunoprecipitation, chromatin immunoprecipitation (ChIP), dual-luciferase reporter assay, siRNA/overexpression, Western blot, immunohistochemistry in AD patient lesions | PeerJ | Medium | 38250727 |
| 2025 | A phenylalanine amide compound (Compound 8.1) promotes FLG expression and other skin barrier-related genes in normal human epidermal keratinocytes through aryl hydrocarbon receptor (AHR) activation; AHR knockdown abolishes this effect; structure-activity analysis shows the compound preferentially activates keratinocyte differentiation genes while minimally inducing CYP1A1, suggesting dissociation of AHR-mediated barrier gene induction from xenobiotic toxicity pathways. | NHEK culture, microarray gene expression profiling, AHR siRNA knockdown, structure-activity relationship analysis | Journal of pharmacological sciences | Medium | 40713347 |
Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2005 | Cellular signaling by fibroblast growth factor receptors. | Cytokine & growth factor reviews | 1528 | 15863030 |
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2006 | Klotho converts canonical FGF receptor into a specific receptor for FGF23. | Nature | 1447 | 17086194 |
| 1996 | Receptor specificity of the fibroblast growth factor family. | The Journal of biological chemistry | 1425 | 8663044 |
| 1993 | Structural and functional diversity in the FGF receptor multigene family. | Advances in cancer research | 1173 | 8417497 |
| 2015 | The BioPlex Network: A Systematic Exploration of the Human Interactome. | Cell | 1118 | 26186194 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 2006 | Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. | The Journal of biological chemistry | 974 | 16597617 |
| 2000 | Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. | Molecular cell | 958 | 11030354 |
| 1997 | Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. | Science (New York, N.Y.) | 954 | 9139660 |
| 2018 | VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. | Cell discovery | 829 | 29507755 |
| 2003 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | Nature genetics | 754 | 14702039 |
| 2012 | Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. | Cell | 708 | 22939624 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2020 | FGF/FGFR signaling in health and disease. | Signal transduction and targeted therapy | 678 | 32879300 |
| 2010 | Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. | Science translational medicine | 673 | 21160078 |
| 1990 | Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. | The EMBO journal | 673 | 1697263 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2009 | Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. | Science signaling | 652 | 19920251 |
| 2007 | Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. | The Journal of biological chemistry | 645 | 17623664 |
| 2012 | Transforming fusions of FGFR and TACC genes in human glioblastoma. | Science (New York, N.Y.) | 640 | 22837387 |
| 2010 | FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. | Cancer research | 585 | 20179196 |
| 2005 | A quantitative protein interaction network for the ErbB receptors using protein microarrays. | Nature | 568 | 16273093 |
| 2003 | Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome. | Nature genetics | 566 | 12627230 |
| 1991 | FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. | The EMBO journal | 553 | 1709094 |
| 2021 | Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. | Nature | 532 | 33845483 |
| 1994 | A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. | Nature genetics | 504 | 7874169 |
| 1999 | Structural basis for FGF receptor dimerization and activation. | Cell | 494 | 10490103 |
| 1994 | Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | Gene | 492 | 8125298 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 1991 | A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. | Molecular and cellular biology | 411 | 1656221 |
| 1991 | Developmental expression of two murine fibroblast growth factor receptors, flg and bek. | Development (Cambridge, England) | 376 | 1667382 |
| 2009 | A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. | Nature genetics | 352 | 19349982 |
| 1992 | A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 286 | 1403086 |
| 1991 | BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers. | Oncogene | 245 | 1851551 |
| 2006 | Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. | The Journal of investigative dermatology | 243 | 16990802 |
| 1989 | Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG). | Proceedings of the National Academy of Sciences of the United States of America | 217 | 2554327 |
| 2012 | The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort. | The Journal of allergy and clinical immunology | 167 | 22951058 |
| 1992 | Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo. | Developmental biology | 144 | 1321062 |
| 2009 | FLG mutations in ichthyosis vulgaris and atopic eczema: spectrum of mutations and population genetics. | The British journal of dermatology | 122 | 19958351 |
| 1990 | The murine flg gene encodes a receptor for fibroblast growth factor. | Oncogene | 121 | 2161096 |
| 2007 | Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort. | Acta dermato-venereologica | 90 | 17989887 |
| 1992 | Expression and immunochemical analysis of rat and human fibroblast growth factor receptor (flg) isoforms. | The Journal of biological chemistry | 88 | 1325449 |
| 2019 | The IL-13-OVOL1-FLG axis in atopic dermatitis. | Immunology | 85 | 31509236 |
| 2000 | HERG K+ channels activation during beta(1) integrin-mediated adhesion to fibronectin induces an up-regulation of alpha(v)beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1. | The Journal of biological chemistry | 74 | 11080495 |
| 1994 | aFGF, bFGF and flg mRNAs show distinct patterns of induction in the hippocampus following kainate-induced seizures. | The European journal of neuroscience | 73 | 7510570 |
| 1992 | Phorbol ester induced osteoclast-like differentiation of a novel human leukemic cell line (FLG 29.1). | The Journal of cell biology | 72 | 1309813 |
| 1991 | Flg-2, a new member of the family of fibroblast growth factor receptors. | Oncogene | 66 | 1648703 |
| 2006 | Expression of vascular endothelial growth factor, basic fibroblast growth factor, and their receptors (flt-1, flk-1, and flg-1) in canine vascular tumors. | Veterinary pathology | 62 | 17099154 |
| 2003 | Flagellar basal body flg operon as a virulence determinant of Vibrio vulnificus. | Biochemical and biophysical research communications | 59 | 12711330 |
| 2009 | FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema. | The British journal of dermatology | 56 | 19663875 |
| 2008 | Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk. | The Journal of allergy and clinical immunology | 55 | 18774391 |
| 2016 | Alterations in Epidermal Eicosanoid Metabolism Contribute to Inflammation and Impaired Late Differentiation in FLG-Mutated Atopic Dermatitis. | The Journal of investigative dermatology | 53 | 27793761 |
| 2011 | Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on FLG knock-down. | Alternatives to laboratory animals : ATLA | 51 | 22103940 |
| 2018 | Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1. | International journal of molecular sciences | 47 | 29866992 |
| 1995 | Developmental expression of fibroblast growth factor receptor-1 (cek-1; flg) during heart development. | Developmental dynamics : an official publication of the American Association of Anatomists | 46 | 7734730 |
| 1992 | Expression and transforming activity of a variant of the heparin-binding fibroblast growth factor receptor (flg) gene resulting from splicing of the alpha exon at an alternate 3'-acceptor site. | Biochemical and biophysical research communications | 46 | 1312829 |
| 1989 | A Salmonella typhimurium virulence gene linked to flg. | Infection and immunity | 46 | 2680969 |
| 1996 | FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth. | Developmental dynamics : an official publication of the American Association of Anatomists | 45 | 8853990 |
| 2003 | A polar flagella operon (flg) of Aeromonas hydrophila contains genes required for lateral flagella expression. | Microbial pathogenesis | 44 | 12732473 |
| 1993 | Identification of tyrosines 154 and 307 in the extracellular domain and 653 and 766 in the intracellular domain as phosphorylation sites in the heparin-binding fibroblast growth factor receptor tyrosine kinase (flg). | Protein science : a publication of the Protein Society | 42 | 8443592 |
| 2009 | Analysis of Taiwanese ichthyosis vulgaris families further demonstrates differences in FLG mutations between European and Asian populations. | The British journal of dermatology | 41 | 19416262 |
| 2020 | Granzyme B Contributes to Barrier Dysfunction in Oxazolone-Induced Skin Inflammation through E-Cadherin and FLG Cleavage. | The Journal of investigative dermatology | 40 | 32504614 |
| 2000 | Rapid upregulation of fibroblast growth factor receptor 1 (flg) by rat photoreceptor cells after injury. | Investigative ophthalmology & visual science | 40 | 10670490 |
| 1996 | Human osteoclasts and preosteoclast cells (FLG 29.1) express functional c-kit receptors and interact with osteoblast and stromal cells via membrane-bound stem cell factor. | Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research | 40 | 8780889 |
| 2021 | Nuclear IL-33 Plays an Important Role in the Suppression of FLG, LOR, Keratin 1, and Keratin 10 by IL-4 and IL-13 in Human Keratinocytes. | The Journal of investigative dermatology | 37 | 33865911 |
| 2021 | New Treatments for Atopic Dermatitis Targeting Skin Barrier Repair via the Regulation of FLG Expression. | Journal of clinical medicine | 37 | 34198894 |
| 2015 | Novel FLG null mutations in Korean patients with atopic dermatitis and comparison of the mutational spectra in Asian populations. | The Journal of dermatology | 37 | 25997159 |
| 1995 | Expression of fibroblast growth factor receptors flg and bek during hepatic ontogenesis and regeneration in the rat. | Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research | 33 | 8547216 |
| 2017 | GATA3 regulates FLG and FLG2 expression in human primary keratinocytes. | Scientific reports | 32 | 28928464 |
| 2021 | Nuclear IL-33 Plays an Important Role in IL-31‒Mediated Downregulation of FLG, Keratin 1, and Keratin 10 by Regulating Signal Transducer and Activator of Transcription 3 Activation in Human Keratinocytes. | The Journal of investigative dermatology | 27 | 34293350 |
| 2009 | Ichthyosis vulgaris: novel FLG mutations in the German population and high presence of CD1a+ cells in the epidermis of the atopic subgroup. | The British journal of dermatology | 27 | 19183181 |
| 2008 | Dystrophic epidermolysis bullosa pruriginosa is not associated with frequent FLG gene mutations. | The British journal of dermatology | 27 | 18565177 |
| 2017 | The Value of FLG Null Mutations in Predicting Treatment Response in Atopic Dermatitis: An Observational Study in Finnish Patients. | Acta dermato-venereologica | 23 | 27840886 |
| 2013 | Carriers of filaggrin gene (FLG) mutations avoid professional exposure to irritants in adulthood. | Contact dermatitis | 21 | 23808934 |
| 1991 | The expression of two isoforms of the human fibroblast growth factor receptor (flg) is directed by alternative splicing. | Biochemical and biophysical research communications | 21 | 1847058 |
| 2019 | Induction of in planta resistance by flagellin (Flg) and elongation factor-TU (EF-Tu) of Bacillus amyloliquefaciens (VB7) against groundnut bud necrosis virus in tomato. | Microbial pathogenesis | 20 | 31557504 |
| 1995 | Biosynthesis of bone sialoprotein by a human osteoclast-like cell line (FLG 29.1). | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 20 | 7754798 |
| 1999 | 17beta-estradiol induces apoptosis in the preosteoclastic FLG 29.1 cell line. | Biochemical and biophysical research communications | 19 | 10049770 |
| 1998 | Expression of Src family kinases and their putative substrates in the human preosteoclastic cell line FLG 29.1. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 18 | 9844106 |
| 2022 | LncRNA FLG-AS1 Mitigates Diabetic Retinopathy by Regulating Retinal Epithelial Cell Inflammation, Oxidative Stress, and Apoptosis via miR-380-3p/SOCS6 Axis. | Inflammation | 17 | 35461393 |
| 2013 | Analyses of FLG mutation frequency and filaggrin expression in isolated ichthyosis vulgaris (IV) and atopic dermatitis-associated IV. | The British journal of dermatology | 17 | 23290076 |
| 2023 | Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 Editing of Human Keratinocytes. | The Journal of investigative dermatology | 16 | 36893939 |
| 2022 | FLG Deficiency in Mice Alters the Early-Life CD4+ T-Cell Response to Skin Commensal Bacteria. | The Journal of investigative dermatology | 16 | 36496196 |
| 1997 | A human homolog of the 150 kD avian osteoclast membrane antigen related to superoxide dismutase and essential for bone resorption is induced by developmental agents and opposed by estrogen in FLG 29.1 cells. | Calcified tissue international | 16 | 9056169 |
| 2022 | FLG Gene Mutation Up-regulates the Abnormal Tumor Immune Response and Promotes the Progression of Prostate Cancer. | Current pharmaceutical biotechnology | 14 | 35422210 |
| 2012 | Usefulness of a global clinical ichthyosis vulgaris scoring system for predicting common FLG null mutations in an adult caucasian population. | The British journal of dermatology | 14 | 22612618 |
| 2005 | Effect of bee venom on aromatase expression and activity in leukaemic FLG 29.1 and primary osteoblastic cells. | Journal of ethnopharmacology | 14 | 15894134 |
| 1991 | Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg). | Biochemical and biophysical research communications | 14 | 1648916 |
| 2019 | Prevalence of FLG loss-of-function mutations R501X, 2282del4, and R2447X in Spanish children with atopic dermatitis. | Pediatric dermatology | 13 | 31637781 |
| 2020 | In vivo Raman spectroscopy discriminates between FLG loss-of-function carriers vs wild-type in day 1-4 neonates. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology | 12 | 32035937 |
| 2018 | Epistasis between FLG and IL4R Genes on the Risk of Allergic Sensitization: Results from Two Population-Based Birth Cohort Studies. | Scientific reports | 12 | 29459738 |
| 1998 | Aromatase expression and activity in the human leukaemic cell line FLG 29.1. | The Journal of steroid biochemistry and molecular biology | 12 | 9719444 |
| 2022 | Association of FLG mutation with tumor mutation load and clinical outcomes in patients with gastric cancer. | Frontiers in genetics | 11 | 36046250 |
| 2021 | Low Threshold for Cutaneous Allergen Sensitization but No Spontaneous Dermatitis or Atopy in FLG-Deficient Mice. | The Journal of investigative dermatology | 11 | 33894197 |
| 2011 | Genetic Polymorphism of FLG in Korean Ichthyosis Vulgaris Patients. | Annals of dermatology | 11 | 21747615 |
| 2017 | Association of FLG single nucleotide variations with clinical phenotypes of atopic dermatitis. | PloS one | 10 | 29281699 |
| 2021 | Investigation of the role of IL18, IL-1β and NLRP3 inflammasome in reducing expression of FLG-2 protein in Psoriasis vulgaris skin lesions. | Biotechnic & histochemistry : official publication of the Biological Stain Commission | 9 | 34313166 |
| 2021 | CDKN1A/p21WAF1, RB1, ARID1A, FLG, and HRNR mutation patterns provide insights into urinary tract environmental exposure carcinogenesis and potential treatment strategies. | American journal of cancer research | 9 | 34873472 |
| 2018 | Exacerbation of ichthyosis vulgaris phenotype by co-inheritance of STS and FLG mutations in a Chinese family with ichthyosis: a case report. | BMC medical genetics | 9 | 30021537 |
| 2016 | Coexistence of 2282del4 FLG gene mutation and IL-18 -137G/C gene polymorphism enhances the risk of atopic dermatitis. | Postepy dermatologii i alergologii | 9 | 26985181 |
| 2022 | Nickel penetration into stratum corneum in FLG null carriers-A human experimental study. | Contact dermatitis | 8 | 35474514 |
| 2014 | The nickel dose-response relationship by filaggrin genotype (FLG). | Contact dermatitis | 8 | 24673390 |
| 2024 | GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis. | PeerJ | 7 | 38250727 |
| 2021 | Combination of FLG mutations and SNPs of IL-17A and IL-19 influence on atopic dermatitis occurrence. | Postepy dermatologii i alergologii | 7 | 35369616 |
| 2013 | No remarkable differences in rates of sensitization to common type I and IV allergens between FLG loss-of-function mutation carriers and wild-type subjects. | Contact dermatitis | 7 | 23848345 |
| 2012 | Interactions between FLG mutations and allergens in atopic dermatitis. | Archives of dermatological research | 7 | 22903496 |
| 2018 | Aberrant Uptake of a Fluorescent L-Glucose Analogue (fLG) into Tumor Cells Expressing Malignant Phenotypes. | Biological & pharmaceutical bulletin | 6 | 30270319 |
| 1997 | Heterogeneity of binding sites and bioeffects of raloxifene on the human leukemic cell line FLG 29.1. | Biochemical and biophysical research communications | 6 | 9398606 |
| 1995 | Evidence for bioeffects of LY 139478 on the human pre-osteoclastic cell line FLG 29.1. | Biochemical and biophysical research communications | 6 | 7598715 |
| 2012 | Novel FLG mutations associated with ichthyosis vulgaris in the Chinese population. | Clinical and experimental dermatology | 5 | 22299762 |
| 1992 | Characterization of [125I]acidic fibroblast growth factor binding to the cloned human fibroblast growth factor receptor, FGF-flg, on NIH 3T3 cell membranes: inhibitory effects of heparin, pertussis toxin and guanine nucleotides. | The Journal of pharmacology and experimental therapeutics | 5 | 1383494 |
| 2021 | Using a Machine Learning Approach to Identify Low-Frequency and Rare FLG Alleles Associated with Remission of Atopic Dermatitis. | JID innovations : skin science from molecules to population health | 4 | 34909743 |
| 2018 | Whole exome sequencing identified two point mutations of COL7A1 and FLG in a Chinese family with dystrophic epidermolysis bullous pruriginosa and ichthyosis vulgaris. | The Journal of dermatology | 4 | 30549102 |
| 2024 | Long Non-Coding RNA FLG-AS1 Inhibits Cervical Cancer Progression through Negatively Modulating miR-147b. | Annals of clinical and laboratory science | 3 | 38802144 |
| 2012 | Common FLG mutation K4671X not associated with atopic dermatitis in Han Chinese in a family association study. | PloS one | 3 | 23152869 |
| 2006 | Effect of Buthus martensi Karsch on aromatase activity and cytokine-inducted NOS and NO production in osteoblasts and leukaemic cell line FLG 29.1. | Immunopharmacology and immunotoxicology | 3 | 16873093 |
| 2004 | Basic fibroblast growth factor (bFGF) and its receptor expression (bek and flg) In bone marrow stroma of murine AIDS. | Virus research | 3 | 15041185 |
| 2024 | Loss-of-function FLG mutations are associated with reduced history of acne vulgaris in a cohort of patients with atopic eczema of Bangladeshi ancestry in East London. | Clinical and experimental dermatology | 2 | 38747172 |
| 2023 | Relevance of Coding Variation in FLG And DOCK8 in Finnish Pediatric Patients with Early-Onset Moderate-To-Severe Atopic Dermatitis. | JID innovations : skin science from molecules to population health | 2 | 37533579 |
| 2022 | Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation. | Journal of dermatological science | 2 | 35537882 |
| 2021 | Combination of FLG mutations and SNP of TSLP (rs1898671) influence on atopic dermatitis occurrence. | Postepy dermatologii i alergologii | 2 | 35369618 |
| 2020 | Stem Cell Research Lab Resource: Stem Cell LineInduced pluripotent stem cell (iPSC) line MLi-003A derived from an individual with the maximum number of filaggrin (FLG) tandem repeats. | Stem cell research | 2 | 32361315 |
| 2020 | Massively Parallel Sequencingof the Filaggrin Gene Reveals an Association Between FLG Loss-of-function Mutations and Leprosy. | Acta dermato-venereologica | 2 | 33047146 |
| 2016 | FLG single nucleotide polymorphisms in chronic idiopathic urticaria. | Allergologia et immunopathologia | 2 | 26796858 |
| 2002 | Gravitational unloading induces osteoclast-like differentiation of FLG 29.1 cells. | Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology | 2 | 15002571 |
| 2025 | A study on drug delivery and release kinetics of polyethylene glycol-functionalized few-layer graphene (FLG) incorporated into a gelatin-chitosan bio-composite film. | RSC advances | 1 | 41293278 |
| 2023 | Genetic polymorphism (rs6587666) in FLG protects from eczema in admixed Brazilian children population with high African ancestry. | Heliyon | 1 | 36865480 |
| 2012 | (1)H, (13)C and (15)N resonance assignments of the Onconase FL-G zymogen. | Biomolecular NMR assignments | 1 | 22392335 |
| 2025 | Phenylalanine amide derivatives promote FLG expression via AHR activation in normal human epidermal keratinocytes. | Journal of pharmacological sciences | 0 | 40713347 |