Affinage

FCER1A

High affinity immunoglobulin epsilon receptor subunit alpha · UniProt P12319

Length
257 aa
Mass
29.6 kDa
Annotated
2026-04-28
78 papers in source corpus 22 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FCER1A encodes the IgE-binding α-subunit of the high-affinity IgE receptor (FcεRI), serving as the primary determinant of IgE recognition on mast cells, basophils, and a subset of sensory neurons, thereby coupling humoral IgE to cellular effector responses in allergy and immunity. The IgE-binding interface maps to the second extracellular immunoglobulin-like domain — particularly residues K117, W130, and Y131 — while the IgE Cε2 domain stabilizes the complex by slowing dissociation more than 10-fold (PMID:9398286, PMID:11823511, PMID:11323720). Surface expression of FcεRIα is transcriptionally driven by PU.1, GATA1, and GATA2 and post-transcriptionally stabilized by monomeric IgE, which prevents lysosomal turnover without triggering signaling; efficient surface trafficking additionally requires co-expression of FcεRIγ, and a co-expressed natural antisense transcript (FCER1A-AS) is essential for sense mRNA and protein production (PMID:24639354, PMID:12752595, PMID:31430311, PMID:37154775). Beyond canonical mast cell/basophil activation, FcεRIα expressed on trigeminal sensory neurons directly mediates IgE-immune-complex-evoked itch independently of mast cells (PMID:35197064).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1996 High

    Establishing that FcεRIα's extracellular domain and FcεRIγ's cytoplasmic tail are both required for full IgE-mediated signaling resolved the division of labor within the receptor complex — ligand recognition versus signal transduction.

    Evidence Chimeric receptor domain-swap experiments in RBL-2H3 cells with multiple functional readouts (IP production, Ca²⁺, degranulation)

    PMID:8648137

    Open questions at the time
    • No structural model of α–γ interface
    • Contribution of FcεRIβ to signaling not resolved in this system
  2. 1997 High

    Identification of K117 as a critical IgE-contact residue defined the molecular binding interface on FcεRIα's α2 domain and showed that affinity is governed primarily by dissociation kinetics.

    Evidence Site-directed mutagenesis of soluble FcεRIα with quantitative SPR kinetics

    PMID:9398286

    Open questions at the time
    • Full binding footprint not yet mapped
    • No crystal structure of complex at this time
  3. 1998 High

    Demonstrating that IgE itself upregulates FcεRIα surface expression on basophils established a positive-feedback loop between circulating IgE and receptor density, directly relevant to allergic sensitization.

    Evidence Flow cytometry and Western blot of basophils cultured with graded IgE concentrations, with anti-FcεRIα blocking

    PMID:9473229

    Open questions at the time
    • Mechanism of upregulation (stabilization vs. synthesis) not yet distinguished
    • In vivo confirmation lacking
  4. 2001 High

    Showing that the IgE Cε2 domain directly contacts FcεRIα and slows dissociation >10-fold explained the exceptionally long half-life of the IgE–FcεRI complex.

    Evidence NMR chemical shift perturbation, sedimentation equilibrium, and dissociation kinetics of Cε2-deleted IgE-Fc

    PMID:11323720

    Open questions at the time
    • Atomic-resolution structure of Cε2–FcεRIα interface not determined
    • Role of Cε2 in allergen cross-linking geometry unknown
  5. 2002 High

    Expanding the IgE contact map to W130 and Y131 and demonstrating species-specific differences refined the binding-surface model and informed therapeutic targeting of the α2 domain.

    Evidence Crystal-structure-guided mutagenesis with SPR using human and mouse IgE

    PMID:11823511

    Open questions at the time
    • Energetic contributions of individual contacts not fully decomposed
    • No co-crystal with bound IgE at atomic resolution at this point
  6. 2003 High

    Distinguishing stabilization from signaling resolved how monomeric IgE increases FcεRIα density: IgE protects FcεRIα from lysosomal degradation without triggering activation, whereas only cross-linked IgE initiates signaling.

    Evidence Flow cytometry, Ca²⁺ flux, tyrosine phosphorylation assays, and lysosomal degradation studies in KU812 cells

    PMID:12752595

    Open questions at the time
    • Exact lysosomal sorting signals on FcεRIα not identified
    • Whether stabilization involves conformational change or steric shielding unresolved
  7. 2006 High

    Identifying the -344C>T promoter polymorphism and its differential binding of transcription factor MAZ provided the first molecular mechanism for genetically encoded variation in FcεRIα expression levels.

    Evidence Luciferase reporter assay and EMSA in RBL-2H3 cells

    PMID:17125826

    Open questions at the time
    • In vivo relevance to atopic disease risk not functionally validated
    • Interaction with other promoter-bound factors not examined
  8. 2014 High

    Demonstrating that PU.1, GATA1, and GATA2 each bind the FCER1A promoter and are individually required for FcεRIα expression and IgE-mediated degranulation established the core transcription factor network controlling receptor expression in human mast cells.

    Evidence ChIP, EMSA, luciferase reporter, siRNA knockdown with flow cytometry and degranulation assays in LAD2 and primary mast cells

    PMID:24639354

    Open questions at the time
    • Combinatorial logic of PU.1/GATA cooperativity not dissected
    • Epigenetic regulation of the locus not addressed
  9. 2019 Medium

    Showing that FcεRIγ co-expression is required for efficient FcεRIα surface trafficking independently of mRNA levels resolved the post-translational bottleneck in receptor assembly.

    Evidence Stable transfection of FcεRIγ into RBL reporter cells with calibrated flow cytometry and qPCR

    PMID:31430311

    Open questions at the time
    • Direct α–γ interaction interface not mapped
    • Role of FcεRIβ in trafficking not examined in this system
  10. 2022 High

    Discovery that FcεRIα is expressed on trigeminal sensory neurons and directly mediates IgE-immune-complex-evoked itch independently of mast cells expanded the receptor's functional repertoire beyond immune cells.

    Evidence Calcium imaging, global FcεRIα KO mice, AAV-mediated neuronal-specific knockdown, and behavioral itch assays in allergic conjunctivitis model

    PMID:35197064

    Open questions at the time
    • Downstream neuronal signaling pathway not defined
    • Whether neuronal FcεRI contains β/γ subunits unknown
    • Relevance to non-ocular itch or pain not tested
  11. 2023 High

    Establishing that a natural antisense transcript (FCER1A-AS) is essential for FCER1A sense mRNA and protein expression — with knockout mice phenocopying FcεRIα deficiency — revealed a non-coding RNA layer of receptor regulation.

    Evidence CasRx knockdown in mast cells plus FCER1A-AS knockout mice tested in Schistosoma infection and passive cutaneous anaphylaxis models

    PMID:37154775

    Open questions at the time
    • Mechanism of antisense-mediated stabilization (RNA duplex, chromatin, or splicing) not defined
    • Tissue specificity of antisense regulation not characterized

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the atomic-resolution mechanism by which FCER1A-AS stabilizes sense mRNA, the downstream signaling pathway in sensory neurons, the structural basis of the FcεRIα–γ assembly interaction, and whether neuronal FcεRI assembles with β and γ subunits.
  • Neuronal FcεRI subunit composition unknown
  • Antisense RNA mechanism of action uncharacterized
  • No high-resolution structure of full tetrameric receptor in membrane context

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 4
Localization
GO:0005886 plasma membrane 5 GO:0005764 lysosome 2
Pathway
R-HSA-168256 Immune System 6 R-HSA-162582 Signal Transduction 4 R-HSA-74160 Gene expression (Transcription) 4
Partners
FCER1GGATA1GATA2IGHEMAZMS4A2PU.1YY1
Complex memberships
FcεRI (high-affinity IgE receptor tetramer: αβγ2)

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 Site-directed mutagenesis of soluble FcεRIα identified K117 in the second immunoglobulin-like domain as a critical contact residue for IgE binding; K117D reduced IgE-binding affinity ~30-fold, and D159K increased affinity ~7-fold, both primarily through changes in dissociation rates, defining the IgE contact surface on FcεRIα. Site-directed mutagenesis + surface plasmon resonance (SPR) binding kinetics + circular dichroism Biochemistry High 9398286
1998 IgE binding to FcεRIα upregulates cell-surface FcεRIα expression on human basophils in vitro in a dose-dependent manner; this upregulation requires IgE interaction through FcεRIα itself (blocked by anti-FcεRIα mAb CGP51901 and inhibited by dimeric IgE), and follows a linear time course over two weeks. Flow cytometry, Western blotting of whole-cell lysates, in vitro basophil culture with IgE Blood High 9473229
1998 Anti-FcεRIα IgG autoantibodies in chronic urticaria patients activate basophil histamine release via complement (C5a receptor pathway); IgG1/IgG3 complement-fixing subtypes mediate this activity, and C5a receptor blockade or decomplementation drastically reduces histamine-releasing capacity. ELISA, Western blotting, histamine release assay, C5a receptor blockade, decomplementation The Journal of clinical investigation High 9421487
1996 Chimeric receptor experiments in RBL-2H3 cells showed that both the extracellular domain of FcεRIα and the cytoplasmic tail of FcεRIγ are essential for FcεRI-mediated signaling (inositol phosphate production, tyrosine phosphorylation, Ca2+ mobilization, histamine and arachidonic acid metabolite secretion); FcεRIα extracellular domain also modulates the magnitude of signaling events. Chimeric receptor expression in RBL-2H3 cells, inositol phosphate assay, tyrosine phosphorylation, Ca2+ mobilization, histamine/arachidonic acid secretion Journal of immunology High 8648137
2001 The IgE Cε2 domain contributes to the exceptionally long half-life of the IgE–FcεRIα complex; deletion of Cε2 from IgE Fc increases the dissociation rate from FcεRIα by >10-fold; NMR chemical shift perturbation showed Cε2 interacts directly with FcεRIα, and sedimentation equilibrium showed Cε2 also binds the Cε3-4 fragment. NMR (heteronuclear) structure determination, chemical shift perturbation, sedimentation equilibrium, dissociation kinetics Nature structural biology High 11323720
2001 FcεRIα exists in two glycosylation states on basophils (50 kDa and 60 kDa bands); the 60 kDa band correlates with surface-expressed FcεRIα, and FcεRIβ protein levels correlate with surface FcεRIα (Spearman R=0.92), demonstrating variable FcεRIα:β stoichiometry that can be altered by IL-3 culture. Western blotting, flow cytometry, real-time PCR, IL-3 culture The Journal of allergy and clinical immunology Medium 11344350
2000 Upregulation of FcεRIα by IgE on basophils increases responsiveness to antigenic challenge (enhanced histamine and IL-4 release at suboptimal antigen concentrations) but is not always accompanied by coordinated upregulation of all IgE-signaling pathway components, indicating that functional upregulation can be modulated independently. Basophil culture with IgE, flow cytometry, histamine and IL-4 secretion assays, antigen dose-response Journal of leukocyte biology Medium 11037968
2002 Mutagenesis of human FcεRIα combined with the crystal structure identified three residues in the C-C' region of the α2 domain (K117, W130, Y131) and two in the α1 domain (R15, F17) as important for IgE binding; K117 and W130 have different effects on human vs. mouse IgE binding, indicating species-specific contact differences. Site-directed mutagenesis, SPR binding assays with human and mouse IgE Journal of immunology High 11823511
2003 Monomeric IgE stabilizes FcεRIα on basophils (KU812 cell line) by protecting it from temperature-dependent lysosomal turnover, without inducing intracellular signaling (no tyrosine phosphorylation or Ca2+ release); only cross-linked IgE triggers signaling. Flow cytometry, Western blotting, immunoradiometric assay, Ca2+ fluorescence (Fura-2), tyrosine phosphorylation assay Clinical and experimental allergy High 12752595
2006 The FcεRIα promoter polymorphism -344C>T increases promoter activity in mast cells (RBL-2H3 luciferase reporter assay), and the -344C allele preferentially binds transcription factor Myc-associated zinc finger protein (MAZ) as shown by EMSA, providing a molecular mechanism for differential FcεRIα expression. Luciferase reporter assay, electrophoretic mobility shift assay (EMSA) The Journal of allergy and clinical immunology High 17125826
2006 IgE-Fc (Fcε) undergoes an unfolding transition at pH below 5.0 in its Cε3-Cε4 receptor-binding domains that abrogates interaction with FcεRIα; at neutral and mildly acidic pH (≥5.5) high-affinity binding is maintained, but interaction is lost at pH <5.0. Circular dichroism, differential scanning calorimetry, isothermal titration calorimetry, SPR-based binding assay at varying pH The Journal of biological chemistry High 16905745
2009 The FcεRIα distal promoter polymorphism -18483A>C (rs2494262) affects transcriptional activity through differential binding of the YY1 transcription factor; the -18483C allele preferentially binds YY1, resulting in lower transcriptional activity compared to the -18483A allele. EMSA (YY1 binding preference), luciferase reporter assay Immunogenetics High 19685047
2014 Transcription factors PU.1, GATA1, and GATA2 are required for FcεRIα (FCER1A) expression in human mast cells; ChIP showed all three bind the FCER1A promoter; siRNA knockdown of each reduces FcεRIα mRNA and surface expression, and GATA2 additionally transactivates FcεRIβ (MS4A2) promoter via direct binding verified by EMSA and luciferase assay. Knockdown of these factors also suppresses IgE-mediated degranulation. siRNA knockdown, ChIP, luciferase reporter assay, EMSA, flow cytometry, real-time PCR, degranulation assay in LAD2 cells and primary mast cells Journal of immunology High 24639354
1998 The membrane-proximal FG loop (residues 154-165) of FcεRIα contributes to IgE binding; W156A mutation abolishes binding of inhibitory mAb 15/1 (which competes with IgE) but does not affect IgE binding itself, indicating distinct but overlapping epitopes within this structural motif. Site-directed mutagenesis, binding assays, peptide library phage display for epitope mapping FEBS letters Medium 9883889
2010 Both IgE-dependent (anti-IgE) and IgE-independent stimulation (FMLP, C5a) of human basophils increases the immature intracellular form of FcεRIα (p46) by reversing lysosomal degradative pathways rather than increasing synthesis; IL-3 increases FcεRIα by enhancing synthesis via a distinct pathway (synergy with bafilomycin A). Western blotting, quantitative PCR, pulse-chase labeling, lysosomal inhibitor (bafilomycin A) treatment International archives of allergy and immunology Medium 20664273
2013 Anti-FcεRIα mAb rapid desensitization suppresses IgE-mediated anaphylaxis in mice by first decreasing mast cell FcεRI signaling, then inducing mast cell unresponsiveness by removing membrane FcεRI; this approach is safer and more durable than antigen desensitization. Mouse anaphylaxis models (active and passive), flow cytometry, histamine/mast cell protease release assays, cytokine measurement, calcium flux The Journal of allergy and clinical immunology Medium 23632296
2019 FcεRIα surface expression levels correlate with co-expression of FcεRIγ in RBL reporter cell lines; stable transfection with FcεRIγ increases FcεRIα surface expression, indicating that FcεRIγ co-expression post-translationally promotes FcεRIα surface trafficking independent of gene copy number or mRNA levels. Flow cytometry with calibration microspheres, qPCR, RT-qPCR, stable transfection PloS one Medium 31430311
2022 FcεRIα is expressed in a subpopulation of conjunctival sensory (trigeminal) neurons; IgE-immune complex directly activates these neurons and evokes ocular itch independently of conjunctival mast cell activation; neuronal-specific knockdown of FcεRIα (via AAV) significantly reduces ocular itch in an OVA-induced allergic conjunctivitis model without affecting immune cell infiltration. Calcium imaging, global FcεRIα KO mice, AAV-mediated neuronal-specific FcεRIα knockdown, behavioral itch assays, immunohistochemistry, Western blot, RT-PCR Journal of neuroinflammation High 35197064
2023 A natural antisense transcript (FCER1A-AS) co-expressed with FCER1A-S is required for sense transcript and FcεRIα protein expression in mast cells; CasRx-mediated knockdown of FCER1A-AS markedly decreases FCER1A-S mRNA and FcεRIα protein; FCER1A-AS-deficient mice phenocopy FcεRIα knockout mice in Schistosoma infection survival and IgE-mediated cutaneous anaphylaxis. CRISPR/CasRx knockdown, in vivo FCER1A-AS knockout mice, Schistosoma infection model, passive cutaneous anaphylaxis model, RT-PCR, Western blot Microbiology spectrum High 37154775
2025 YH35324, a hybrid FcεRIα extracellular domain protein, binds IgE-unoccupied FcεRIα on mast cells (LAD2), is internalized via actin-dependent endocytosis, recycled via FcRn binding in lysosomes, and suppresses FcεRIα surface expression more effectively than omalizumab in basophils from allergic patients. Flow cytometry, immunoblot, immunocytochemistry, ELISA, pharmacological inhibition of endocytosis, FcRn binding assay Allergy, asthma & immunology research Medium 40204504
2001 GM-CSF dose- and time-dependently reduces FcεRIα mRNA and protein expression in human mast cells (HMC-1 and cord blood-derived mast cells) in vitro, accompanied by decreased histamine levels and tryptase activity, demonstrating that GM-CSF selectively inhibits mast cell differentiation markers including FcεRIα. mRNA analysis, immunoreactivity staining, intracellular histamine/tryptase assay, in vitro mast cell culture Archives of dermatological research Medium 11409570
2014 CD72 agonistic antibody (K10.6) induces phosphorylation of the ubiquitin ligase Cbl-b and decreases FcεRIα (and KIT) surface expression on mouse bone marrow-derived mast cells, suppressing IgE-triggered degranulation; this mechanism is species-dependent (different from human mast cells where CD72 does not suppress IgE/FcεRI responses). Flow cytometry, Western blotting (Cbl-b phosphorylation), IgE-triggered degranulation assay, agonistic antibody treatment International immunology Medium 25239131

Source papers

Stage 0 corpus · 78 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS genetics 212 18846228
1998 Anti-FcepsilonRIalpha autoantibodies in autoimmune-mediated disorders. Identification of a structure-function relationship. The Journal of clinical investigation 203 9421487
1998 In vitro regulation of FcepsilonRIalpha expression on human basophils by IgE antibody. Blood 119 9473229
2006 Significant association of FcepsilonRIalpha promoter polymorphisms with aspirin-intolerant chronic urticaria. The Journal of allergy and clinical immunology 92 17125826
2001 The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha. Nature structural biology 68 11323720
1997 Identification of contact residues in the IgE binding site of human FcepsilonRIalpha. Biochemistry 52 9398286
1999 Human anti-FcepsilonRIalpha autoantibodies isolated from healthy donors cross-react with tetanus toxoid. European journal of immunology 50 10229080
2001 Expression and modulation of FcepsilonRIalpha and FcepsilonRIbeta in human blood basophils. The Journal of allergy and clinical immunology 46 11344350
2006 The alpha-chain of high-affinity receptor for IgE (FcepsilonRIalpha) gene polymorphisms and serum IgE levels. Allergy 43 16942574
2013 Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 39 23725541
2001 GM-CSF downmodulates c-kit, Fc(epsilon)RI(alpha) and GM-CSF receptor expression as well as histamine and tryptase levels in cultured human mast cells. Archives of dermatological research 36 11409570
2013 Rapid polyclonal desensitization with antibodies to IgE and FcεRIα. The Journal of allergy and clinical immunology 35 23632296
2009 Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk. Allergy 33 20028371
2014 Critical Roles for PU.1, GATA1, and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. Journal of immunology (Baltimore, Md. : 1950) 31 24639354
2004 Natural anti-FcepsilonRIalpha autoantibodies may interfere with diagnostic tests for autoimmune urticaria. Journal of autoimmunity 30 14709412
2000 Functional consequences of FcepsilonRIalpha up-regulation by IgE in human basophils. Journal of leukocyte biology 29 11037968
2017 House Dust Mite-Induced Allergic Airway Disease Is Independent of IgE and FcεRIα. American journal of respiratory cell and molecular biology 26 28700253
2019 Role of the IgE variable heavy chain in FcεRIα and superantigen binding in allergy and immunotherapy. The Journal of allergy and clinical immunology 25 30995457
2009 Common variants in FCER1A influence total serum IgE levels from cord blood up to six years of life. Allergy 25 19245427
2013 A role of FCER1A and FCER2 polymorphisms in IgE regulation. Allergy 23 24354852
2017 Detection of circulating IgG autoantibody to FcεRIα in sera from chronic spontaneous urticaria patients. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 21 29169972
2011 Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population. Human immunology 20 22222815
2014 Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients. Archives of dermatological research 19 25412950
2010 FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. International journal of immunogenetics 19 20141544
2001 Natural anti-FcepsilonRIalpha autoantibodies isolated from healthy donors and chronic idiopathic urticaria patients reveal a restricted repertoire and autoreactivity on human basophils. Human antibodies 19 11847423
2014 A rapid method of detecting autoantibody against FcεRIα for chronic spontaneous urticaria. PloS one 18 25333273
2011 Human mast cell line-1 (HMC-1) cells transfected with FcεRIα are sensitive to IgE/antigen-mediated stimulation demonstrating selectivity towards cytokine production. International immunopharmacology 18 21356342
2015 Targeting Mast Cells and Basophils with Anti-FcεRIα Fab-Conjugated Celastrol-Loaded Micelles Suppresses Allergic Inflammation. Journal of biomedical nanotechnology 17 26510321
2009 Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha). Immunologic research 17 18726713
2006 An intermediate pH unfolding transition abrogates the ability of IgE to interact with its high affinity receptor FcepsilonRIalpha. The Journal of biological chemistry 17 16905745
1996 Functional contributions of the FcepsilonRIalpha and FepsilonRIgamma subunit domains in FcepsilonRI-mediated signaling in mast cells. Journal of immunology (Baltimore, Md. : 1950) 16 8648137
2019 Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies. The Journal of allergy and clinical immunology 15 31836406
2011 Comparison between sensitivity of autologous skin serum test and autologous plasma skin test in patients with Chronic Idiopathic Urticaria for detection of antibody against IgE or IgE receptor (FcεRIα). Iranian journal of allergy, asthma, and immunology 15 21625019
2022 Neuronal FcεRIα directly mediates ocular itch via IgE-immune complex in a mouse model of allergic conjunctivitis. Journal of neuroinflammation 14 35197064
2019 Differentiation between control subjects and patients with chronic spontaneous urticaria based on the ability of anti-IgE autoantibodies (AAbs) to induce FcεRI crosslinking, as compared to anti-FcεRIα AAbs. Allergology international : official journal of the Japanese Society of Allergology 13 30803853
2005 A high-affinity natural autoantibody from human cord blood defines a physiologically relevant epitope on the FcepsilonRIalpha. Journal of immunology (Baltimore, Md. : 1950) 12 16272313
2020 Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs. The Journal of allergy and clinical immunology 11 33326804
2009 FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding. Immunogenetics 11 19685047
2003 Monomeric immunoglobulin E stabilizes FcepsilonRIalpha from the human basophil cell line KU812 by protecting it from natural turnover. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 11 12752595
2019 Characterization of human FcεRIα chain expression and gene copy number in humanized rat basophilic leukaemia (RBL) reporter cell lines. PloS one 10 31430311
2002 Mutagenesis within human FcepsilonRIalpha differentially affects human and murine IgE binding. Journal of immunology (Baltimore, Md. : 1950) 10 11823511
1998 The membrane-proximal part of FcepsilonRIalpha contributes to human IgE and antibody binding--implications for a general structural motif in Fc receptors. FEBS letters 10 9883889
2018 The Fab fragment of anti-IgE Cε2 domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells. Scientific reports 9 30250145
2010 SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population. PloS one 8 21209833
2020 Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis. Human immunology 7 32883546
2017 Treatment with anti-FcεRIα antibody exacerbates EAE and T-cell immunity against myelin. Neurology(R) neuroimmunology & neuroinflammation 7 28616446
2014 CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcεRIα. International immunology 7 25239131
2013 Sex-specific differences in the relationship between the single-nucleotide polymorphism rs2298804 of FCER1A and the susceptibility to systemic lupus erythematosus in a Chinese Han population. Clinical and experimental dermatology 7 23621092
2011 A comparative search for human FcεRIα gene (FCER1A) 3'-UTR polymorphisms in Japanese and Polish populations. Molecular biology reports 7 21725845
2009 Production of human monoclonal antibodies against Fc(epsilon)RI(alpha) by a method combining in vitro immunization with phage display. Bioscience, biotechnology, and biochemistry 7 19584553
2024 Fiber rich food suppressed airway inflammation, GATA3 + Th2 cells, and FcεRIα+ eosinophils in asthma. Frontiers in nutrition 6 38757128
2013 Identification of amino acid residues involved in the interaction of canine IgE with canine and human FcεRIα. Molecular immunology 6 24084098
2016 Antibody to FcεRIα Suppresses Immunoglobulin E Binding to High-Affinity Receptor I in Allergic Inflammation. Yonsei medical journal 5 27593869
2009 FcepsilonRI-alpha siRNA inhibits the antigen-induced activation of mast cells. Iranian journal of allergy, asthma, and immunology 5 20404387
2008 FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians. International journal of immunogenetics 5 18680511
2022 Detection of serum IgG autoantibodies to FcεRIα by ELISA in patients with chronic spontaneous urticaria. PloS one 4 35984815
2012 Measurement for canine IgE using canine recombinant high affinity IgE receptor α chain (FcεRIα). The Journal of veterinary medical science 4 22322186
2009 Inhibition of IgE Activity to Bind its High Affinity Receptor (FcεRIα) by Mouse Anti-IgE Cε3∼4 Monoclonal Antibody (QME5). International journal of biomedical science : IJBS 4 23675156
2001 Direct expression of the extracellular portion of human FcepsilonRIalpha chain as inclusion bodies in Escherichia coli. Bioscience, biotechnology, and biochemistry 4 11272849
2025 Therapeutic Efficacy of YH35324 on FcεRIα-Mediated Mast Cell/Basophil Activation. Allergy, asthma & immunology research 3 40204504
2025 Diagnostic Use of CCR3, CD63, CD203c and FcεRIα on Blood Leukocytes of Allergic Asthma and Combined Allergic Rhinitis and Asthma Syndrome. Journal of cellular and molecular medicine 3 40534099
2024 Protection against DSS-induced colitis in mice through FcεRIα deficiency: the role of altered Lactobacillus. NPJ biofilms and microbiomes 3 39266529
2023 A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcεRIα. Microbiology spectrum 3 37154775
2021 Expression of FcεRIα and tryptase in human lung tissue during drug-induced anaphylactic death. Forensic science, medicine, and pathology 3 34383238
2019 Genetic variation in FCER1A predicts peginterferon alfa-2a-induced hepatitis B surface antigen clearance in East Asian patients with chronic hepatitis B. Journal of viral hepatitis 3 30972912
2001 Expression of humanized Fab fragments that recognize the IgE-binding domain of human Fc(epsilon)RIalpha in COS and CHO cells. Journal of biochemistry 3 11134951
2021 Genetic association study of CTLA4 and FCεRIα polymorphisms in asthmatic patients in the southwestern region of Iran. Nucleosides, nucleotides & nucleic acids 2 34420484
2021 IFNG, FCER1A, PCDHB10 expression as a new potential marker of efficacy in grass pollen allergen-specific immunotherapy. Postepy dermatologii i alergologii 2 34658711
2010 IgE-dependent and IgE-independent stimulation of human basophils increases the presence of immature FcεRIα by reversing degradative pathways. International archives of allergy and immunology 2 20664273
2000 Kinetic analysis of the interaction between recombinant human Fc(epsilon)RIalpha and serum IgEs from allergic patients. Clinical immunology (Orlando, Fla.) 2 10866125
2024 The relationship between Fc epsilon receptor-1α and β (FCER1A and FCER1B) gene polymorphisms in patients with chronic urticaria using omalizumab. Postepy dermatologii i alergologii 1 39290894
2017 Isolation of Natural Anti-FcεRIα Autoantibodies from Healthy Donors. Methods in molecular biology (Clifton, N.J.) 1 28667526
2015 Treatment with Anti-FcεRIα (MAR-1) Antibody Prevents Acute Islet Allograft Rejection in a Murine Model. The Tokai journal of experimental and clinical medicine 1 26662664
2013 The role of Cε2, Cε3, and Cε4 domains in human and canine IgE and their contribution to FcεRIα interaction. Molecular immunology 1 24091297
2025 FCER1A Downregulation in Infectious Pneumonia: A Multi-Modal Study Combining Bioinformatics, Animal Models, and Reverse Pharmacology. Genes 0 41300746
2018 Report-Model studies of transmembrane interaction of FcεRIα/FcRγ reveal novel strategies to inhibit allergic responses. Pakistan journal of pharmaceutical sciences 0 30150199
2017 Establishment of a novel quantum dots-encoded microbead-based flow cytometric method for quantification of soluble FcεRIα in serum. Cytometry. Part A : the journal of the International Society for Analytical Cytology 0 28505391
2012 [Association analysis between single-nucleotide polymorphisms in the FCER1A gene and serum total IgE level in patients with allergic rhinitis]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 0 22800345