Affinage

FCER1A

High affinity immunoglobulin epsilon receptor subunit alpha · UniProt P12319

Length
257 aa
Mass
29.6 kDa
Annotated
2026-06-09
79 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FCER1A encodes the IgE-binding α-subunit of the high-affinity IgE receptor (FcεRI), the central trigger of allergic effector responses in mast cells and basophils (PMID:8648137, PMID:20404387). Its second immunoglobulin-like (α2) domain forms the IgE-Fc binding interface, with K117, W130, and Y131, together with α1/α2 interface residues R15 and F17, acting as direct contact residues whose mutation reduces IgE affinity, principally by accelerating dissociation; species-specific contact geometry distinguishes human from mouse IgE binding (PMID:9398286, PMID:11823511). The membrane-proximal FG loop forms an additional 3D structural element contributing to IgE attachment (PMID:9883889), and the exceptionally slow dissociation of the complex is reinforced by the IgE Cε2 domain, whose deletion increases off-rate >10-fold (PMID:11323720); the complex is pH-sensitive, dissociating below pH 5.0 as the IgE Cε3–Cε4 domains unfold (PMID:16905745). Signaling requires both the FcεRIα extracellular domain and the FcεRIγ cytoplasmic tail: chimeric receptor studies show the γ tail is essential for inositol phosphate production, tyrosine phosphorylation, Ca2+ flux and secretion, while the α ectodomain modulates signaling magnitude (PMID:8648137), and FcεRIα is required for IgE/antigen-triggered degranulation (PMID:20404387). Surface expression is transcriptionally controlled by PU.1, GATA1 and GATA2 binding the FCER1A promoter, with GATA2 additionally transactivating the β-subunit gene MS4A2 (PMID:24639354), and is post-translationally stabilized by monomeric IgE, which protects FcεRIα from lysosomal turnover without inducing signaling (PMID:12752595); efficient surface trafficking depends on FcεRIγ co-expression (PMID:31430311). Beyond classical immune cells, FcεRIα is expressed on a subset of sensory neurons where it directly mediates IgE-immune-complex-evoked itch independently of mast cells (PMID:35197064). In disease, anti-FcεRIα autoantibodies from chronic urticaria patients release basophil histamine through a complement (C5a)-dependent mechanism (PMID:9421487), and therapeutic strategies exploit antibodies or α-ectodomain hybrid proteins that target unoccupied receptor to drive FcεRI downregulation and suppress anaphylaxis (PMID:23632296, PMID:40204504).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1996 High

    Established the division of labor within FcεRI: which subunit transduces signal versus binds ligand, a prerequisite for understanding receptor activation.

    Evidence Chimeric receptor aggregation in RBL-2H3 cells with IP, phosphorylation, Ca2+ and secretion readouts

    PMID:8648137

    Open questions at the time
    • Does not resolve the structural basis of α–γ assembly
    • α ectodomain's modulatory contribution to signaling magnitude not mechanistically defined
  2. 1997 High

    Identified specific FcεRIα residues forming the IgE-binding interface, moving the receptor from a binding 'black box' to defined contact chemistry.

    Evidence Site-directed mutagenesis of soluble ectodomain with SPR kinetics and CD validation

    PMID:9398286

    Open questions at the time
    • Single-residue scan, not full interface map
    • No co-crystal structure in this study
  3. 1998 High

    Demonstrated that IgE itself upregulates its own receptor on basophils, revealing a positive feedback loop linking IgE levels to allergic sensitivity.

    Evidence Basophil culture with IgE plus blocking mAb, flow cytometry and Western blot

    PMID:9473229

    Open questions at the time
    • Mechanism of stabilization not defined at this stage
    • Functional consequence for cell responsiveness not yet quantified
  4. 1998 High

    Explained how anti-FcεRIα autoantibodies cause disease, distinguishing histamine-releasing from non-releasing autoantibodies by complement-fixing subtype.

    Evidence Basophil histamine release assay with C5a receptor blockade, decomplementation and IgG subclass analysis

    PMID:9421487

    Open questions at the time
    • Did not map autoantibody epitopes on FcεRIα
    • Relative in vivo contribution of complement vs direct receptor crosslinking unresolved
  5. 1998 Medium

    Defined the membrane-proximal FG loop as an additional structural element of the IgE-binding region distinct from the inhibitory mAb epitope.

    Evidence Mutagenesis of ecFcεRIα-HSA fusion with antibody-binding assays and peptide library screening

    PMID:9883889

    Open questions at the time
    • Epitope mapping, not direct affinity measurement of FG-loop mutants for IgE
    • 3D structural model inferred indirectly
  6. 2001 High

    Resolved why the IgE–FcεRIα bond is exceptionally long-lived, attributing slow dissociation in part to the IgE Cε2 domain.

    Evidence Heteronuclear NMR, sedimentation equilibrium and SPR with IgE deletion mutants

    PMID:11323720

    Open questions at the time
    • Cε2 contribution measured on isolated Fc, not full antibody in cellular context
  7. 2002 High

    Extended the binding-residue map using crystal-structure guidance and uncovered species-specific contact geometry between human and mouse IgE.

    Evidence Structure-guided mutagenesis of human FcεRIα with SPR against human and mouse IgE

    PMID:11823511

    Open questions at the time
    • Functional consequence of species differences in vivo not addressed
  8. 2003 Medium

    Distinguished IgE's receptor-stabilizing effect from receptor signaling, showing monomeric IgE blocks lysosomal turnover without triggering activation.

    Evidence Turnover/IRMA assays, phosphorylation and Fura-2 Ca2+ measurements in KU812 cells

    PMID:12752595

    Open questions at the time
    • Trafficking machinery mediating lysosomal protection not identified
    • Cell-line system may not fully reflect primary basophils
  9. 2006 High

    Showed the IgE–FcεRIα complex is pH-sensitive, providing a mechanism for intracellular regulation of receptor-bound IgE.

    Evidence CD, DSC, ITC and pH-titration binding assays

    PMID:16905745

    Open questions at the time
    • In vivo relevance of intracellular pH-driven dissociation not directly demonstrated
  10. 2006 Medium

    Defined cis-regulatory polymorphisms and the transcription factors that govern FCER1A promoter activity, linking genetics to receptor expression.

    Evidence Luciferase reporter assays and EMSA mapping MAZ and YY1 binding to promoter variants in RBL-2H3 cells

    PMID:17125826 PMID:19685047

    Open questions at the time
    • Effect on endogenous FcεRIα levels in vivo not established
    • Clinical phenotype association not demonstrated
  11. 2014 High

    Identified the master transcription factors (PU.1, GATA1, GATA2) controlling FCER1A and coordinately MS4A2 expression in mast cells.

    Evidence siRNA knockdown, ChIP, EMSA, reporter assays and degranulation readouts in LAD2 and primary mast cells

    PMID:24639354

    Open questions at the time
    • Upstream signals controlling these factors during mast cell differentiation not defined
  12. 2019 Medium

    Established that FcεRIγ co-expression, not gene dosage or mRNA, limits FcεRIα surface display, defining the trafficking bottleneck.

    Evidence Quantitative flow cytometry, copy-number/mRNA quantification and FcεRIγ transfection rescue in humanized RBL reporters

    PMID:31430311

    Open questions at the time
    • Molecular steps of γ-dependent trafficking not resolved
    • Reporter cell context may differ from primary cells
  13. 2022 High

    Revealed a mast-cell-independent function of FcεRIα in sensory neurons directly driving allergic itch.

    Evidence Calcium imaging, global knockout, AAV neuron-specific knockdown and behavioral itch assays in allergic conjunctivitis

    PMID:35197064

    Open questions at the time
    • Neuronal signaling pathway downstream of FcεRIα not defined
    • Whether neuronal FcεRIα uses the same γ-subunit assembly as immune cells unknown
  14. 2025 Medium

    Demonstrated a therapeutic strategy in which an FcεRIα-ectodomain hybrid drives receptor internalization and downregulation via actin-dependent endocytosis and FcRn recycling.

    Evidence Flow cytometry, immunocytochemistry, actin inhibitors and soluble FcεRIα ELISA in LAD2 cells and basophils

    PMID:40204504

    Open questions at the time
    • Durability and in vivo efficacy at the receptor level not fully characterized
    • Single-lab cellular study

Open questions

Synthesis pass · forward-looking unresolved questions
  • How FcεRIα assembles, traffics and signals in non-immune (sensory neuron) compartments, and the structural rules of subunit stoichiometry remain open.
  • Neuronal FcεRIα subunit composition and downstream effectors unknown
  • No high-resolution structure of the assembled membrane receptor in the corpus
  • Mechanism coupling α ectodomain conformation to signal magnitude unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0001618 virus receptor activity 3 GO:0060089 molecular transducer activity 3
Localization
GO:0005764 lysosome 3 GO:0005886 plasma membrane 3
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 2 R-HSA-74160 Gene expression (Transcription) 1
Partners
FCER1GIGHEMS4A2
Complex memberships
FcεRI (high-affinity IgE receptor)

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 Site-directed mutagenesis of the soluble FcεRIα ectodomain identified K117 (in the second immunoglobulin-like domain) as a critical IgE-contact residue: K117D reduced IgE-binding affinity ~30-fold, principally by increasing the dissociation rate. D159K increased affinity ~7-fold. CD spectra confirmed native fold was preserved, establishing these as true contact residues in the IgE:FcεRIα interface. Site-directed mutagenesis of recombinant sFcεRIα + surface plasmon resonance kinetics + circular dichroism Biochemistry High 9398286
1998 IgE upregulates FcεRIα surface expression on human basophils in vitro via a mechanism that requires IgE binding to FcεRIα itself: the anti-IgE/FcεRIα-blocking mAb CGP51901 blocked upregulation, dimeric IgE was inhibitory, and heat-inactivated IgE was less effective. Upregulation was linear over 2 weeks and dose-dependent on IgE concentration (EC50 ~230 ng/mL). Flow cytometry, Western blot of whole-cell lysates, culture of purified human basophils with/without IgE and blocking antibodies Blood High 9473229
1998 Anti-FcεRIα IgG autoantibodies from chronic urticaria patients release histamine from basophils through a complement-dependent mechanism: C5a receptor blockade and decomplementation drastically reduced histamine-releasing activity. The histamine-releasing autoantibodies were predominantly of complement-fixing IgG1/IgG3 subtype, whereas non-releasing autoantibodies from other autoimmune diseases were mainly IgG2/IgG4. ELISA, Western blot, basophil histamine release assay with C5a receptor blockade and decomplementation The Journal of clinical investigation High 9421487
1996 The extracellular domain of FcεRIα and the cytoplasmic tail of FcεRIγ are both essential for FcεRI-mediated mast cell signaling. Chimeric receptor aggregation studies in RBL-2H3 cells showed that replacing the FcεRIγ cytoplasmic tail abolished all signaling (inositol phosphate production, tyrosine phosphorylation, Ca2+ mobilization, secretion), while the FcεRIα extracellular domain modulated the magnitude of signaling events. Chimeric receptor expression in RBL-2H3 cells, inositol phosphate assay, tyrosine phosphorylation, Ca2+ mobilization, histamine and arachidonic acid secretion Journal of immunology High 8648137
2001 The IgE Cε2 domain contributes to the exceptionally slow dissociation of the IgE–FcεRIα complex. Deletion of Cε2 from IgE Fc increased the dissociation rate from FcεRIα by >10-fold. NMR chemical shift perturbation showed Cε2 directly interacts with FcεRIα, and sedimentation equilibrium showed Cε2 binds to the Cε3–4 fragment intramolecularly. Heteronuclear NMR spectroscopy (structure + chemical shift perturbation), sedimentation equilibrium, surface plasmon resonance with deletion mutants Nature structural biology High 11323720
2001 FcεRIα surface expression on basophils correlates tightly with FcεRIβ protein levels (Spearman R=0.92). A 50 kDa form of FcεRIα (intracellular/immature) is present in similar amounts across donors regardless of surface expression level, whereas the 60 kDa surface form correlates with flow-cytometric FcεRIα. IL-3 culture increases FcεRIβ protein and mRNA disproportionately without increasing surface FcεRIα, indicating variable α:β stoichiometry that can be modulated by cytokines. Western blot, flow cytometry, real-time PCR, basophil culture with IL-3 The Journal of allergy and clinical immunology Medium 11344350
2002 Mutagenesis guided by the FcεRIα/IgE crystal structure identified key binding residues in the FcεRIα2 domain (K117, W130, Y131) and at the α1/α2 interface (R15, F17). All three α2 mutations reduced human IgE affinity, with differential effects on mouse IgE binding (K117D severely reduced mouse IgE binding; W130A modestly enhanced mouse IgE binding), demonstrating species-specific contact geometry. Site-directed mutagenesis of human FcεRIα + surface plasmon resonance with human and mouse IgE Journal of immunology High 11823511
2003 Monomeric IgE stabilizes FcεRIα on basophils (KU812 cell line) by protecting it from constitutive lysosomal/temperature-dependent turnover, not by inducing signaling. Monomeric IgE did not induce tyrosine phosphorylation or Ca2+ release (only cross-linked IgE did), but reduced the 16-fold loss of FcεRIα at 37°C to only 3-fold in 5 hours. Immunoradiometric assay for soluble FcεRIα, flow cytometry, Western blot for tyrosine phosphorylation, Fura-2 Ca2+ measurement, temperature-controlled turnover assay Clinical and experimental allergy Medium 12752595
2006 The FcεRIα–IgE complex is abrogated at pH below 5.0 because the Cε3–Cε4 receptor-binding domains of IgE Fc unfold at these pH values. At pH 6.0 binding affinity was unchanged; at pH 5.5 only modestly reduced. The apparent affinity of Fcε for a dimeric Fcγ-FcεRIα fusion protein under neutral conditions was <10⁻¹² M (vs. monomer values in literature). This pH sensitivity may regulate receptor-bound IgE intracellularly. Circular dichroism, differential scanning calorimetry, isothermal titration calorimetry, pH-titration binding assays The Journal of biological chemistry High 16905745
2006 The FcεRIα promoter −344C>T polymorphism increases promoter transcriptional activity in mast cells: the −344T allele drove significantly higher luciferase reporter activity in RBL-2H3 cells than the −344C allele. EMSA showed that transcription factor Myc-associated zinc finger protein (MAZ) preferentially bound the −344C allele, suggesting MAZ represses transcription from the −344C allele. Luciferase reporter assay in RBL-2H3 cells, electrophoretic mobility shift assay (EMSA) The Journal of allergy and clinical immunology Medium 17125826
2009 The FcεRIα distal promoter polymorphism −18483A>C (rs2494262) reduces transcriptional activity through preferential binding of the YY1 transcription factor to the −18483C allele. The −18483C allele showed lower reporter activity, and EMSA confirmed preferential YY1 binding to the C allele. Luciferase reporter assay, EMSA with YY1 antibody supershift Immunogenetics Medium 19685047
2014 Transcription factors PU.1, GATA1, and GATA2 all directly bind the FCER1A promoter and transactivate FcεRIα expression in human mast cells. siRNA knockdown of each factor in LAD2 cells downregulated FCER1A mRNA and FcεRI surface expression. ChIP confirmed PU.1, GATA1, and GATA2 occupancy at the FCER1A promoter. GATA2 additionally transactivates the FcεRIβ gene (MS4A2). All knockdowns suppressed IgE-mediated degranulation. siRNA knockdown, flow cytometry, qRT-PCR, chromatin immunoprecipitation (ChIP), luciferase reporter assay, EMSA, primary mast cell experiments Journal of immunology High 24639354
2000 IgE-mediated upregulation of FcεRIα on basophils increases cellular sensitivity to antigen stimulation (histamine and IL-4 release), particularly at suboptimal antigen concentrations, but does not increase responsiveness to anti-IgE or anti-receptor antibodies. A 6-fold increase in antigen-specific IgE density produced a 2.2-fold improvement in antigen potency, indicating upregulation of FcεRI is not always accompanied by balanced upregulation of all downstream signaling components. Basophil culture with IgE, antigen challenge for histamine and IL-4 release, flow cytometry for receptor density Journal of leukocyte biology Medium 11037968
2010 IgE-dependent (anti-IgE) and IgE-independent (FMLP, C5a) stimulation of basophils both increase the immature intracellular FcεRIα (p46) form by reversing lysosomal degradation rather than by increasing synthesis. Bafilomycin A (lysosomal inhibitor) and secretagogues showed no synergy, suggesting convergence on the same degradative pathway. IL-3 and bafilomycin A were synergistic, indicating IL-3 acts via increased synthesis. Quantitative PCR, Western blot, pulse-chase metabolic labeling, bafilomycin A pharmacology International archives of allergy and immunology Medium 20664273
2013 Rapid desensitization with anti-FcεRIα monoclonal antibodies that bind only unoccupied (IgE-free) FcεRI suppressed IgE-mediated anaphylaxis in mice without inducing disease. The mechanism involved two phases: initial decrease in mast cell FcεRI signaling, followed by removal of membrane FcεRI (receptor internalization/downregulation), leading to prolonged mast cell unresponsiveness. Murine passive and active anaphylaxis models, hypothermia measurement, histamine/mast cell protease release, cytokine secretion, Ca2+ flux, flow cytometry for FcεRI/IgE expression The Journal of allergy and clinical immunology High 23632296
2001 GM-CSF induces dose- and time-dependent reduction of FcεRIα mRNA and protein expression in both HMC-1 leukemic mast cells and normal cord blood-derived mast cells, with concomitant decreases in intracellular histamine, tryptase activity, and c-Kit expression. This selective inhibition occurs irrespective of the growth factors (SCF, NGF, fibroblast supernatant) present, indicating GM-CSF is a negative regulator of mast cell differentiation markers including FcεRIα. Immunocytochemistry, mRNA expression analysis, histamine measurement, tryptase activity assay, mast cell culture with GM-CSF Archives of dermatological research Medium 11409570
2009 siRNA knockdown of FcεRIα in murine MC/9 mast cells significantly decreased FcεRIα mRNA, protein, and surface expression, and inhibited antigen-induced histamine and β-hexosaminidase release, establishing FcεRIα as required for IgE/antigen-triggered mast cell degranulation. siRNA transfection, real-time PCR, Western blot, flow cytometry, ELISA for histamine, spectrophotometry for β-hexosaminidase Iranian journal of allergy, asthma, and immunology Medium 20404387
2011 Stable transfection of FcεRIα α-subunit into HMC-1 mast cells (which lack native FcεRI) confers IgE-sensitization and antigen-triggered cytokine release via p38 MAPK and ERK phosphorylation, without degranulation or detectable Ca2+ flux or general tyrosine phosphorylation. Src kinase inhibitor PP2, and p38/ERK inhibitors attenuated IgE/antigen-induced cytokine release. Stable transfection, flow cytometry, signaling assays (p38/Erk phosphorylation), pharmacological inhibitors, cytokine ELISA, Ca2+ measurement International immunopharmacology Medium 21356342
2019 FcεRIα surface expression in humanized RBL reporter cell lines correlates with co-expression of FcεRIγ subunit, not with FcεRIα gene copy number or steady-state mRNA levels. Stable transfection of FcεRIγ into low-expressing NFAT-DsRed cells increased FcεRIα surface levels, indicating FcεRIγ is required for efficient FcεRIα surface stabilization/trafficking. Flow cytometry with calibration microspheres, qPCR for gene copy number, RT-qPCR for mRNA, stable transfection of FcεRIγ PloS one Medium 31430311
2022 FcεRIα is expressed in a subpopulation of conjunctival sensory (trigeminal) neurons and directly mediates IgE-immune-complex-evoked ocular itch independent of mast cell activation. In a global FcεRIα knockout and after AAV-mediated sensory neuron-specific FcεRIα knockdown, ocular itch was significantly reduced in an OVA-induced allergic conjunctivitis model without affecting conjunctival immune cell infiltration or mast cell degranulation. IgE stabilized FcεRIα protein in neurons via a cycloheximide-resistant, lysosomal pathway. Calcium imaging of trigeminal neurons, global knockout mice, AAV-mediated neuron-specific knockdown, behavioral itch assays, immunohistochemistry, Western blot, qRT-PCR Journal of neuroinflammation High 35197064
2014 CD72 activation by agonistic antibody K10.6 in mouse mast cells induces phosphorylation of the ubiquitin ligase Cbl-b and decreases FcεRIα surface expression, thereby suppressing IgE-triggered degranulation. This contrasts with human mast cells where CD72 does not affect IgE/FcεRI-mediated responses, indicating species-specific regulatory coupling between CD72/Cbl-b and FcεRIα. Agonistic antibody treatment, flow cytometry, Western blot for Cbl-b phosphorylation, degranulation assay International immunology Medium 25239131
2025 YH35324, a hybrid protein containing the extracellular domain of FcεRIα, binds to IgE-unoccupied FcεRIα on mast cell surfaces, undergoes actin-dependent endocytosis, and is recycled via FcRn binding in lysosomes, resulting in decreased FcεRIα surface expression on LAD2 cells and peripheral blood basophils. Serum soluble FcεRIα levels increased in YH-treated subjects and correlated positively with free IgE. Flow cytometry, immunoblot, immunocytochemistry, actin polymerization inhibitors, ELISA for soluble FcεRIα, ex vivo basophil analysis Allergy, asthma & immunology research Medium 40204504
1998 The membrane-proximal FG loop of FcεRIα (residues Lys154–Leu165) contributes to IgE binding. The W156A mutation abrogates binding of the inhibitory mAb 15/1 (which blocks IgE/FcεRIα interaction) but does not affect IgE binding, indicating distinct but overlapping epitopes. The membrane-proximal region forms a 3D structural element important for IgE attachment. Site-directed mutagenesis of ecFcεRIα expressed as HSA fusion in eukaryotic cells, antibody-binding assays, peptide library screening on flagella FEBS letters Medium 9883889

Source papers

Stage 0 corpus · 79 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS genetics 212 18846228
1998 Anti-FcepsilonRIalpha autoantibodies in autoimmune-mediated disorders. Identification of a structure-function relationship. The Journal of clinical investigation 203 9421487
1998 In vitro regulation of FcepsilonRIalpha expression on human basophils by IgE antibody. Blood 119 9473229
2006 Significant association of FcepsilonRIalpha promoter polymorphisms with aspirin-intolerant chronic urticaria. The Journal of allergy and clinical immunology 92 17125826
2001 The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha. Nature structural biology 68 11323720
1997 Identification of contact residues in the IgE binding site of human FcepsilonRIalpha. Biochemistry 52 9398286
1999 Human anti-FcepsilonRIalpha autoantibodies isolated from healthy donors cross-react with tetanus toxoid. European journal of immunology 50 10229080
2001 Expression and modulation of FcepsilonRIalpha and FcepsilonRIbeta in human blood basophils. The Journal of allergy and clinical immunology 46 11344350
2006 The alpha-chain of high-affinity receptor for IgE (FcepsilonRIalpha) gene polymorphisms and serum IgE levels. Allergy 43 16942574
2013 Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 40 23725541
2001 GM-CSF downmodulates c-kit, Fc(epsilon)RI(alpha) and GM-CSF receptor expression as well as histamine and tryptase levels in cultured human mast cells. Archives of dermatological research 36 11409570
2013 Rapid polyclonal desensitization with antibodies to IgE and FcεRIα. The Journal of allergy and clinical immunology 35 23632296
2009 Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk. Allergy 34 20028371
2014 Critical Roles for PU.1, GATA1, and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. Journal of immunology (Baltimore, Md. : 1950) 31 24639354
2004 Natural anti-FcepsilonRIalpha autoantibodies may interfere with diagnostic tests for autoimmune urticaria. Journal of autoimmunity 30 14709412
2000 Functional consequences of FcepsilonRIalpha up-regulation by IgE in human basophils. Journal of leukocyte biology 29 11037968
2017 House Dust Mite-Induced Allergic Airway Disease Is Independent of IgE and FcεRIα. American journal of respiratory cell and molecular biology 26 28700253
2019 Role of the IgE variable heavy chain in FcεRIα and superantigen binding in allergy and immunotherapy. The Journal of allergy and clinical immunology 25 30995457
2009 Common variants in FCER1A influence total serum IgE levels from cord blood up to six years of life. Allergy 25 19245427
2013 A role of FCER1A and FCER2 polymorphisms in IgE regulation. Allergy 24 24354852
2017 Detection of circulating IgG autoantibody to FcεRIα in sera from chronic spontaneous urticaria patients. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 23 29169972
2011 Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population. Human immunology 20 22222815
2014 Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients. Archives of dermatological research 19 25412950
2010 FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. International journal of immunogenetics 19 20141544
2001 Natural anti-FcepsilonRIalpha autoantibodies isolated from healthy donors and chronic idiopathic urticaria patients reveal a restricted repertoire and autoreactivity on human basophils. Human antibodies 19 11847423
2014 A rapid method of detecting autoantibody against FcεRIα for chronic spontaneous urticaria. PloS one 18 25333273
2011 Human mast cell line-1 (HMC-1) cells transfected with FcεRIα are sensitive to IgE/antigen-mediated stimulation demonstrating selectivity towards cytokine production. International immunopharmacology 18 21356342
2015 Targeting Mast Cells and Basophils with Anti-FcεRIα Fab-Conjugated Celastrol-Loaded Micelles Suppresses Allergic Inflammation. Journal of biomedical nanotechnology 17 26510321
2009 Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha). Immunologic research 17 18726713
2006 An intermediate pH unfolding transition abrogates the ability of IgE to interact with its high affinity receptor FcepsilonRIalpha. The Journal of biological chemistry 17 16905745
1996 Functional contributions of the FcepsilonRIalpha and FepsilonRIgamma subunit domains in FcepsilonRI-mediated signaling in mast cells. Journal of immunology (Baltimore, Md. : 1950) 16 8648137
2019 Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies. The Journal of allergy and clinical immunology 15 31836406
2011 Comparison between sensitivity of autologous skin serum test and autologous plasma skin test in patients with Chronic Idiopathic Urticaria for detection of antibody against IgE or IgE receptor (FcεRIα). Iranian journal of allergy, asthma, and immunology 15 21625019
2022 Neuronal FcεRIα directly mediates ocular itch via IgE-immune complex in a mouse model of allergic conjunctivitis. Journal of neuroinflammation 14 35197064
2019 Differentiation between control subjects and patients with chronic spontaneous urticaria based on the ability of anti-IgE autoantibodies (AAbs) to induce FcεRI crosslinking, as compared to anti-FcεRIα AAbs. Allergology international : official journal of the Japanese Society of Allergology 13 30803853
2009 FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding. Immunogenetics 12 19685047
2005 A high-affinity natural autoantibody from human cord blood defines a physiologically relevant epitope on the FcepsilonRIalpha. Journal of immunology (Baltimore, Md. : 1950) 12 16272313
2020 Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs. The Journal of allergy and clinical immunology 11 33326804
2003 Monomeric immunoglobulin E stabilizes FcepsilonRIalpha from the human basophil cell line KU812 by protecting it from natural turnover. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 11 12752595
2019 Characterization of human FcεRIα chain expression and gene copy number in humanized rat basophilic leukaemia (RBL) reporter cell lines. PloS one 10 31430311
2002 Mutagenesis within human FcepsilonRIalpha differentially affects human and murine IgE binding. Journal of immunology (Baltimore, Md. : 1950) 10 11823511
1998 The membrane-proximal part of FcepsilonRIalpha contributes to human IgE and antibody binding--implications for a general structural motif in Fc receptors. FEBS letters 10 9883889
2018 The Fab fragment of anti-IgE Cε2 domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells. Scientific reports 9 30250145
2010 SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population. PloS one 8 21209833
2020 Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis. Human immunology 7 32883546
2017 Treatment with anti-FcεRIα antibody exacerbates EAE and T-cell immunity against myelin. Neurology(R) neuroimmunology & neuroinflammation 7 28616446
2014 CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcεRIα. International immunology 7 25239131
2013 Sex-specific differences in the relationship between the single-nucleotide polymorphism rs2298804 of FCER1A and the susceptibility to systemic lupus erythematosus in a Chinese Han population. Clinical and experimental dermatology 7 23621092
2011 A comparative search for human FcεRIα gene (FCER1A) 3'-UTR polymorphisms in Japanese and Polish populations. Molecular biology reports 7 21725845
2009 Production of human monoclonal antibodies against Fc(epsilon)RI(alpha) by a method combining in vitro immunization with phage display. Bioscience, biotechnology, and biochemistry 7 19584553
2024 Fiber rich food suppressed airway inflammation, GATA3 + Th2 cells, and FcεRIα+ eosinophils in asthma. Frontiers in nutrition 6 38757128
2013 Identification of amino acid residues involved in the interaction of canine IgE with canine and human FcεRIα. Molecular immunology 6 24084098
2025 Therapeutic Efficacy of YH35324 on FcεRIα-Mediated Mast Cell/Basophil Activation. Allergy, asthma & immunology research 5 40204504
2016 Antibody to FcεRIα Suppresses Immunoglobulin E Binding to High-Affinity Receptor I in Allergic Inflammation. Yonsei medical journal 5 27593869
2009 FcepsilonRI-alpha siRNA inhibits the antigen-induced activation of mast cells. Iranian journal of allergy, asthma, and immunology 5 20404387
2008 FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians. International journal of immunogenetics 5 18680511
2024 Protection against DSS-induced colitis in mice through FcεRIα deficiency: the role of altered Lactobacillus. NPJ biofilms and microbiomes 4 39266529
2022 Detection of serum IgG autoantibodies to FcεRIα by ELISA in patients with chronic spontaneous urticaria. PloS one 4 35984815
2012 Measurement for canine IgE using canine recombinant high affinity IgE receptor α chain (FcεRIα). The Journal of veterinary medical science 4 22322186
2009 Inhibition of IgE Activity to Bind its High Affinity Receptor (FcεRIα) by Mouse Anti-IgE Cε3∼4 Monoclonal Antibody (QME5). International journal of biomedical science : IJBS 4 23675156
2001 Direct expression of the extracellular portion of human FcepsilonRIalpha chain as inclusion bodies in Escherichia coli. Bioscience, biotechnology, and biochemistry 4 11272849
2025 Diagnostic Use of CCR3, CD63, CD203c and FcεRIα on Blood Leukocytes of Allergic Asthma and Combined Allergic Rhinitis and Asthma Syndrome. Journal of cellular and molecular medicine 3 40534099
2023 A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcεRIα. Microbiology spectrum 3 37154775
2021 Expression of FcεRIα and tryptase in human lung tissue during drug-induced anaphylactic death. Forensic science, medicine, and pathology 3 34383238
2019 Genetic variation in FCER1A predicts peginterferon alfa-2a-induced hepatitis B surface antigen clearance in East Asian patients with chronic hepatitis B. Journal of viral hepatitis 3 30972912
2010 IgE-dependent and IgE-independent stimulation of human basophils increases the presence of immature FcεRIα by reversing degradative pathways. International archives of allergy and immunology 3 20664273
2001 Expression of humanized Fab fragments that recognize the IgE-binding domain of human Fc(epsilon)RIalpha in COS and CHO cells. Journal of biochemistry 3 11134951
2021 Genetic association study of CTLA4 and FCεRIα polymorphisms in asthmatic patients in the southwestern region of Iran. Nucleosides, nucleotides & nucleic acids 2 34420484
2021 IFNG, FCER1A, PCDHB10 expression as a new potential marker of efficacy in grass pollen allergen-specific immunotherapy. Postepy dermatologii i alergologii 2 34658711
2000 Kinetic analysis of the interaction between recombinant human Fc(epsilon)RIalpha and serum IgEs from allergic patients. Clinical immunology (Orlando, Fla.) 2 10866125
2024 The relationship between Fc epsilon receptor-1α and β (FCER1A and FCER1B) gene polymorphisms in patients with chronic urticaria using omalizumab. Postepy dermatologii i alergologii 1 39290894
2017 Isolation of Natural Anti-FcεRIα Autoantibodies from Healthy Donors. Methods in molecular biology (Clifton, N.J.) 1 28667526
2015 Treatment with Anti-FcεRIα (MAR-1) Antibody Prevents Acute Islet Allograft Rejection in a Murine Model. The Tokai journal of experimental and clinical medicine 1 26662664
2013 The role of Cε2, Cε3, and Cε4 domains in human and canine IgE and their contribution to FcεRIα interaction. Molecular immunology 1 24091297
2026 Potentially Functional Variants in FCER1A and PLCG2, Two B Cell-Related Immune Genes Predict the Survival of Chinese Gastric Cancer Patients. Molecular carcinogenesis 0 42138601
2025 FCER1A Downregulation in Infectious Pneumonia: A Multi-Modal Study Combining Bioinformatics, Animal Models, and Reverse Pharmacology. Genes 0 41300746
2018 Report-Model studies of transmembrane interaction of FcεRIα/FcRγ reveal novel strategies to inhibit allergic responses. Pakistan journal of pharmaceutical sciences 0 30150199
2017 Establishment of a novel quantum dots-encoded microbead-based flow cytometric method for quantification of soluble FcεRIα in serum. Cytometry. Part A : the journal of the International Society for Analytical Cytology 0 28505391
2012 [Association analysis between single-nucleotide polymorphisms in the FCER1A gene and serum total IgE level in patients with allergic rhinitis]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 0 22800345

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