F7
Coagulation factor VII · UniProt P08709
- Length
- 466 aa
- Mass
- 51.6 kDa
- Annotated
- 2026-06-13
90 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 90 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1988 | The high efficiency, human B cell immortalizing heteromyeloma CB-F7. Production of human monoclonal antibodies to human immunodeficiency virus. | Journal of immunological methods | 104 | 2828478 |
| 2020 | Development of CAR T Cells Expressing a Suicide Gene Plus a Chimeric Antigen Receptor Targeting Signaling Lymphocytic-Activation Molecule F7. | Molecular therapy : the journal of the American Society of Gene Therapy | 94 | 33129371 |
| 1982 | F7 and type 1-like fimbriae from three Escherichia coli strains isolated from urinary tract infections: protein chemical and immunological aspects. | Infection and immunity | 92 | 6123483 |
| 1993 | A polymorphism in the 5' region of coagulation factor VII gene (F7) caused by an inserted decanucleotide. | Human genetics | 87 | 8381388 |
| 1992 | Detection of two missense mutations and characterization of a repeat polymorphism in the factor VII gene (F7). | Human genetics | 72 | 1634227 |
| 1993 | Serine92 (F7) contributes to the control of heme reactivity and stability in myoglobin. | Biochemistry | 68 | 8494890 |
| 1994 | A new monoclonal antibody (5D3-F7) which recognizes human monocyte-chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells. | Journal of immunological methods | 61 | 8083529 |
| 2012 | Amniotic fluid stem cells restore the muscle cell niche in a HSA-Cre, Smn(F7/F7) mouse model. | Stem cells (Dayton, Ohio) | 54 | 22644669 |
| 2012 | Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery disease. | Journal of medical genetics | 47 | 22315437 |
| 1991 | PCR detection of a repeat polymorphism within the F7 gene. | Nucleic acids research | 44 | 1886792 |
| 2007 | Keratinolytic activity of Bacillus megaterium F7-1, a feather-degrading mesophilic bacterium. | Microbiological research | 40 | 17459685 |
| 1984 | Molecular organisation of the genes involved in the production of F7(2) fimbriae, causing mannose-resistant haemagglutination, of a uropathogenic Escherichia coli 06:K2:H1:F7 strain. | Molecular & general genetics : MGG | 37 | 6146091 |
| 1985 | Comparison of the nucleotide sequences of the genes encoding the KS71A and F7(1) fimbrial antigens of uropathogenic Escherichia coli. | European journal of biochemistry | 36 | 2992970 |
| 2017 | Bioactive compounds of Aspergillus terreus-F7, an endophytic fungus from Hyptis suaveolens (L.) Poit. | World journal of microbiology & biotechnology | 31 | 28243983 |
| 2005 | The F7 gene and clotting factor VII levels: dissection of a human quantitative trait locus. | Human biology | 29 | 16596941 |
| 2013 | Isolation and characterization of a Sphingomonas sp. strain F-7 degrading fenvalerate and its use in bioremediation of contaminated soil. | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes | 26 | 23356341 |
| 2017 | F7 gene variants modulate protein levels in a large cohort of patients with factor VII deficiency. Results from a genotype-phenotype study. | Thrombosis and haemostasis | 25 | 28447100 |
| 2020 | F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia. | Drug delivery | 23 | 32508162 |
| 2016 | Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp. ZSDS1-F7. | Natural product research | 23 | 27417331 |
| 2007 | Functional analysis of the genetic variability in the F7 gene promoter. | Atherosclerosis | 23 | 17292373 |
| 1988 | Biogenesis of F71 and F72 fimbriae of uropathogenic Escherichia coli: influence of the FsoF and FstFG proteins and localization of the Fso/FstE protein. | Molecular microbiology | 23 | 28776787 |
| 1986 | Functional relationship among the gene clusters encoding F7(1), F7(2), F9, and F11 fimbriae of human uropathogenic Escherichia coli. | Journal of bacteriology | 23 | 2873130 |
| 2010 | Impact of pharmacokinetic (CYP2C9) and pharmacodynamic (VKORC1, F7, GGCX, CALU, EPHX1) gene variants on the initiation and maintenance phases of phenprocoumon therapy. | Thrombosis and haemostasis | 22 | 21057703 |
| 2012 | Isolation and characterization of Streptomyces spp. strains F-6 and F-7 capable of decomposing alkali lignin. | Environmental technology | 21 | 23437660 |
| 2010 | Haplotype and genotype effects of the F7 gene on circulating factor VII, coagulation activation markers and incident coronary heart disease in UK men. | Journal of thrombosis and haemostasis : JTH | 19 | 20735728 |
| 2009 | Impaired secretion of carboxyl-terminal truncated factor VII due to an F7 nonsense mutation associated with FVII deficiency. | Thrombosis research | 17 | 19822353 |
| 2013 | Correlation between single nucleotide polymorphism of rs3811047 in IL-1 F7 gene and rheumatoid arthritis susceptibility among Han population in central plains of China. | Asian Pacific journal of tropical medicine | 16 | 23317890 |
| 1991 | Bacteriophage receptors of Lactococcus lactis subsp. 'diacetylactis' F7/2 and Lactococcus lactis subsp. cremoris Wg2-1. | FEMS microbiology letters | 16 | 1903350 |
| 2009 | The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study. | Pharmacogenetics and genomics | 14 | 19415820 |
| 1998 | In vitro and in vivo evaluation of insulin-producing beta TC6-F7 cells in microcapsules. | The American journal of physiology | 13 | 9612223 |
| 2009 | Using a minigene approach to characterize a novel splice site mutation in human F7 gene causing inherited factor VII deficiency in a Chinese pedigree. | Haemophilia : the official journal of the World Federation of Hemophilia | 12 | 19601987 |
| 2005 | Human F7 sequence is split into three deep clades that are related to FVII plasma levels. | Human genetics | 12 | 16292673 |
| 2001 | Abnormal secretion and function of recombinant human factor VII as the result of modification to a calcium binding site caused by a 15-base pair insertion in the F7 gene. | Blood | 12 | 11159523 |
| 1982 | Tests of association of lymphocyte alloantigen genotypes with resistance to viral oncogenesis in chickens. 1. Marek's disease in F7 progeny derived from 6(3) X 15(1) crosses. | Poultry science | 12 | 6131413 |
| 2019 | 2-methylquinazoline derivative F7 as a potent and selective HDAC6 inhibitor protected against rhabdomyolysis-induced acute kidney injury. | PloS one | 11 | 31639165 |
| 1988 | Biogenesis of F7(1) and F7(2) fimbriae of uropathogenic Escherichia coli: influence of the FsoF and FstFG proteins and localization of the Fso/FstE protein. | Molecular microbiology | 11 | 2897068 |
| 2009 | Genotype-phenotype relationship of F7 R353Q polymorphism and plasma factor VII coagulant activity in Asian Indian families predisposed to coronary artery disease. | Journal of genetics | 10 | 20086294 |
| 2002 | Two double heterozygous mutations in the F7 gene show different manifestations. | British journal of haematology | 10 | 12472587 |
| 1986 | Partial expression of monoaminergic (serotoninergic) properties by the multipotent hypothalamic cell line F7. An example of learning at the cellular level. | Neurochemistry international | 10 | 20493099 |
| 2023 | A glucose tolerant β-glucosidase from a newly isolated Neofusicoccum parvum strain F7: production, purification, and characterization. | Scientific reports | 9 | 36991150 |
| 2022 | The structure of AcrIE4-F7 reveals a common strategy for dual CRISPR inhibition by targeting PAM recognition sites. | Nucleic acids research | 9 | 35166843 |
| 2021 | Monocyte Dysfunction Detected by the Designed Ankyrin Repeat Protein F7 Predicts Mortality in Patients Receiving Veno-Arterial Extracorporeal Membrane Oxygenation. | Frontiers in cardiovascular medicine | 9 | 34350217 |
| 2014 | Arrangement of the Clostridium baratii F7 toxin gene cluster with identification of a σ factor that recognizes the botulinum toxin gene cluster promoters. | PloS one | 9 | 24853378 |
| 2010 | The Mediterranean Sea as a barrier to gene flow: evidence from variation in and around the F7 and F12 genomic regions. | BMC evolutionary biology | 9 | 20346176 |
| 2021 | Co-delivery of F7 and crizotinib by thermosensitive liposome for breast cancer treatment. | Journal of liposome research | 8 | 34904521 |
| 2012 | Functional epistatic interaction between rs6046G>A in F7 and rs5355C>T in SELE modifies systolic blood pressure levels. | PloS one | 8 | 22815813 |
| 2007 | Characterisation of a large complex intragenic re-arrangement in the FVII gene (F7) avoiding misdiagnosis in inherited factor VII deficiency. | British journal of haematology | 8 | 17614823 |
| 2007 | Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody. | Cytometry. Part A : the journal of the International Society for Analytical Cytology | 8 | 17879237 |
| 2003 | Prevalence of factor VII deficiency and molecular characterization of the F7 gene in Brazilian patients. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis | 8 | 12695753 |
| 1992 | Hemoglobin Sabine [beta 91 (F7) Leu-->Pro]: occurrence in a Sardinian individual with hemolytic anemia and inclusion bodies. | Haematologica | 8 | 1336469 |
| 2012 | Combined congenital dysfibrinogenemia and factor VII deficiency from mutations in the FGB and F7 genes. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis | 7 | 22576285 |
| 2005 | Novel aberrant splicings caused by a splice site mutation (IVS1a+5g>a) in F7 gene. | Thrombosis and haemostasis | 7 | 15968391 |
| 2015 | Expression and biochemical characterization of light chains of Botulinum neurotoxin subtypes F5 and F7. | Protein expression and purification | 6 | 25858313 |
| 2012 | Lethal factor VII deficiency due to novel mutations in the F7 promoter: functional analysis reveals disruption of HNF4 binding site. | Thrombosis and haemostasis | 6 | 22628013 |
| 2023 | Structural and functional characterization of novel F7 mutations identified in Chinese factor VII-deficient patients. | British journal of haematology | 5 | 36951360 |
| 2017 | HEREDITARY FACTOR VII DEFICIENCY IN THE ASIAN ELEPHANT (ELEPHAS MAXIMUS) CAUSED BY A F7 MISSENSE MUTATION. | Journal of wildlife diseases | 5 | 28118558 |
| 2008 | HER-2 peptides p776 and F7, N-terminal-linked with Ii-Key tetramer (LRMK) help the proliferation of E75-TCR+ cells: The dependency of help on the side chains of LRMK-extended peptide pointed towards the T cell receptor. | Oncology reports | 5 | 18497949 |
| 2006 | Genetic architecture of the F7 gene in a Spanish population: implication for mapping complex diseases and for functional assays. | Clinical genetics | 5 | 16650081 |
| 1990 | GDA-J/F7 monoclonal antibody: a new marker for sperm cell precursors in human semen. | Journal of reproductive immunology | 5 | 2254877 |
| 2019 | Coagulant activity of recombinant human factor VII produced by lentiviral human F7 gene transfer in immortalized hepatocyte-like cell line. | PloS one | 4 | 31381603 |
| 2012 | A biodegradation study of forest biomass by Aspergillus niger F7: correlation between enzymatic activity, hydrolytic percentage and biodegradation index. | Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] | 4 | 24031853 |
| 1999 | Threonine phosphorylations induced by RX-871024 and insulin secretagogues in betaTC6-F7 cells. | The American journal of physiology | 4 | 10567013 |
| 1997 | Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas. | Annals of transplantation | 4 | 9869861 |
| 1990 | [Cloning and expression of Clostridium thermocellum F7 cellulase genes in Escherichia coli and Bacillus subtilis cells]. | Genetika | 4 | 2124195 |
| 1990 | [Cloning and expression of Clostridium thermocellum F7 endoglucanase gene in gram-negative bacteria]. | Genetika | 4 | 2258032 |
| 2018 | Four New C9 Metabolites from the Sponge-Associated Fungus Gliomastix sp. ZSDS1-F7-2. | Marine drugs | 3 | 29987219 |
| 2014 | Immobilization of Aspergillus niger F7-02 Lipase in Polysaccharide Hydrogel Beads of Irvingia gabonensis Matrix. | Enzyme research | 3 | 25614829 |
| 2007 | Clustering of individuals given SNPs similarity based on normalized mutual information: F7 SNPs in the GAIT sample. | Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference | 3 | 18001904 |
| 2022 | Novel heterozygous F7 gene mutation (c. C1286T) associated with congenital factor VII deficiency: A case report and literature review. | Journal of clinical laboratory analysis | 2 | 35349734 |
| 2021 | Compound Heterozygous Mutations in the F7 Gene in 2 Unrelated Families With Congenital Factor VII Deficiency. | Journal of pediatric hematology/oncology | 2 | 33480651 |
| 2013 | Double heterozygous mutations Gln100Leu and His348Gln of the F7 gene in a patient with factor VII deficiency. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis | 2 | 23358202 |
| 2011 | [Polymorphic markers Ala455Val of the THBD gene and Arg353Gln of the F7 gene and association with unfavorable outcomes of coronary atherosclerosis in patients with a history of acute ischemic heart disease]. | Genetika | 2 | 22232927 |
| 1990 | Functional analysis of the fsoC gene product of the F7(1) (fso) fimbrial gene cluster. | Molecular microbiology | 2 | 1969606 |
| 2025 | Nutrient consumption patterns of Streptococcus thermophilus F7 under acid stress and their application in enhancing biomass production. | Journal of dairy science | 1 | 40306427 |
| 2022 | Clinical phenotype and F7 gene genotype in 40 Tunisian patients with congenital factor VII deficiency. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis | 1 | 35802509 |
| 2014 | Quorum sensing activity of Mesorhizobium sp. F7 isolated from potable water. | TheScientificWorldJournal | 1 | 25177734 |
| 2009 | N-terminally LRMK-linked HER-2 peptides, AE-37 [p776(774-788)] and AE-47 [Ava-F7(776-788)], aid differentiation of E75-TCR+CD8+ cells to perforin-positive cells. | Anticancer research | 1 | 19596910 |
| 1989 | Development of specific human mab's by a small scale electrofusion technique: the influence of some physical and chemical factors on hybridoma yield of human peripheral blood lymphocytes XCB-F7 fusions. | Allergie und Immunologie | 1 | 2788981 |
| 2026 | Platelet-derived growth factor receptor β F7 mutations result in and exacerbate the severity of vascular dysplasia in the brain arteriovenous malformation through enhancing angiogenesis. | Angiogenesis | 0 | 42070212 |
| 2025 | [Analysis of a Chinese pedigree affected with hereditary factor Ⅶ deficiency due to compound heterozygous variants of F7 gene]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics | 0 | 41451501 |
| 2024 | [Analysis of three Chinese pedigrees affected with Hereditary factor Ⅶ deficiency due to compound heterozygous variants of F7 gene]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics | 0 | 38565502 |
| 2024 | [Congenital FⅦ Deficiency Associated with a Novel Mutation in F7 Gene]. | Zhongguo shi yan xue ye xue za zhi | 0 | 38926980 |
| 2024 | Synonymous variant at the terminal nucleotide in exon 3 of F7 causes abnormal splicing: A case report. | Molecular genetics & genomic medicine | 0 | 39007454 |
| 2024 | Frequency and Association of Polymorphisms in F2, F7, and PROS1 Coagulation Genes with Disease Severity in Coronavirus Disease 2019. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis | 0 | 39497411 |
| 2022 | Factor VII Deficiency Due to Compound Heterozygosity for the p.Leu13Pro Mutation and a Novel Mutation in the HNF4 Binding Region (-58G>C) in the F7 Promoter. | The Kurume medical journal | 0 | 36123027 |
| 2020 | [Analysis of a Chinese pedigree affected with hereditary factor VII deficiency caused by compound heterozygous variants of F7 gene]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics | 0 | 32472540 |
| 2020 | Generation of a human induced pluripotent stem cell line, YCMi002-A, from a Factor VII deficiency patient carrying F7 mutations. | Stem cell research | 0 | 33038747 |
| 2018 | [Analysis of Phenotype and L12R Mutation in Signal Peptide and 3' Non-translation Region c11814-insAA Mutation of F7 Gene in a Family with Hereditary Coagulation Factor VII Deficiency]. | Zhongguo shi yan xue ye xue za zhi | 0 | 29665924 |
| 2013 | [Cloning, expression and identification of Der f7 gene from Dermatophagoides farinae and its immunological characteristics]. | Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases | 0 | 24818391 |
| 2008 | SNP sets selection under mutual information criterion, application to F7/FVII dataset. | Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference | 0 | 19163535 |
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