Affinage

DUOXA1

Dual oxidase maturation factor 1 · UniProt Q1HG43

Length
343 aa
Mass
37.8 kDa
Annotated
2026-06-09
100 papers in source corpus 7 papers cited in narrative 7 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DUOXA1 is a transmembrane maturation factor that co-assembles with the NADPH oxidase DUOX1 to form an active complex that generates H2O2 (PMID:32929281, PMID:31428054). Cryo-EM structures of the DUOX1-DUOXA1 complex define the interaction interface, a lipid-mediated NADPH-binding pocket, and the electron transfer path, and reveal a dimer-of-dimers configuration that constitutes an inactive state, indicating oligomerization-dependent regulation of the oxidase (PMID:32929281). Intact DUOXA1 is essential for full DUOX1 expression and H2O2 production: a missense mutation (p.R56W) lowers DUOX1 mRNA and protein and impairs H2O2 generation (PMID:31428054), while DUOXA1 and the paralog DUOXA2 are functionally redundant as DUOX maturation partners, with single-allele DUOXA1 sufficiency producing only mild transient hypothyroidism (PMID:21367925). Beyond assembly, DUOXA1 controls DUOX1 trafficking — its N-glycosylation directs apical plasma membrane targeting of DUOX1 in polarized epithelial cells, a role DUOXA2 cannot substitute (PMID:39126279). Through its DUOX1-dependent ROS output, DUOXA1 acts as an upstream signaling input: it inhibits muscle satellite cell differentiation via a DUOX1/ASK1 pathway (PMID:24410844), suppresses cancer cell proliferation and adhesion by modulating p21, integrin αVβ5, CD9, and the actin cytoskeleton (PMID:19322654), and sustains ATR-Chk1 DNA damage signaling to confer cisplatin resistance (PMID:29704517).

Mechanistic history

Synthesis pass · year-by-year structured walk · 7 steps
  1. 2009 Medium

    Established that DUOXA1 (NIP1) exerts cellular effects through DUOX1-dependent ROS, linking a maturation factor to control of proliferation and adhesion rather than acting independently.

    Evidence Overexpression with DUOX1 depletion control plus ROS, p21/integrin/CD9 immunoblotting and cytoskeleton imaging in MDA-MB-231 breast cancer cells

    PMID:19322654

    Open questions at the time
    • Single lab, correlative readouts
    • Direct biochemical demonstration of complex assembly not shown here
    • Physiological relevance of overexpression unclear
  2. 2011 Medium

    Defined DUOXA1 and DUOXA2 as functionally redundant maturation factors required for DUOX enzyme function, clarifying why loss of one paralog is partially tolerated.

    Evidence In vitro reconstitution of DUOXA2(C189R) loss-of-function and clinical genetic mapping of a deletion

    PMID:21367925

    Open questions at the time
    • Degree of redundancy may differ by tissue
    • Does not address trafficking specificity later found to differ between paralogs
  3. 2014 High

    Placed DUOXA1 upstream of a DUOX1/ASK1 ROS signaling cascade that inhibits myogenic differentiation, defining a developmental function for the maturation factor.

    Evidence Adenoviral overexpression in primary myoblasts with siRNA double-knockdown rescue, H2O2 measurement, and differentiation marker immunoblotting

    PMID:24410844

    Open questions at the time
    • Direct ASK1 activation by DUOX1-derived H2O2 not biochemically resolved
    • In vivo relevance to satellite cell biology not tested
  4. 2018 Medium

    Connected DUOXA1-driven ROS to sustained ATR-Chk1 DNA damage signaling, providing a mechanism for platinum chemoresistance.

    Evidence qHTCS screen, RNA-seq, ROS measurement, RNAi/inhibitor knockdown of DUOXA1/ATR/Chk1, and in vitro/in vivo cisplatin resistance assays in ovarian cancer cells

    PMID:29704517

    Open questions at the time
    • Single lab
    • Mechanism by which ROS sustains ATR-Chk1 not molecularly defined
  5. 2019 Medium

    Demonstrated through a patient missense mutation that intact DUOXA1 is required for DUOX1 expression and H2O2 output, cementing its role as an essential co-factor.

    Evidence Direct sequencing, site-directed mutagenesis (p.R56W), mRNA/protein expression analysis, and H2O2 generation assay

    PMID:31428054

    Open questions at the time
    • Single mutation studied
    • How R56W destabilizes DUOX1 mechanistically not resolved
  6. 2020 High

    Resolved the atomic architecture of the DUOX1-DUOXA1 complex and identified an oligomerization-dependent inactive state, explaining how the oxidase is assembled and regulated.

    Evidence Cryo-EM structures of the mouse complex with and without NADPH plus biochemical analyses of the dimer-of-dimers state

    PMID:32929281

    Open questions at the time
    • Mouse structure; human-specific features not addressed
    • Trigger that switches between active and inactive oligomeric states unknown
  7. 2024 High

    Identified DUOXA1 N-glycosylation as the determinant directing apical targeting of DUOX1, revealing a trafficking role distinct from DUOXA2.

    Evidence Co-expression in polarized MDCK cells with N-glycosylation mutants, specificity controls, and immunofluorescence localization

    PMID:39126279

    Open questions at the time
    • Glycan-reading sorting machinery not identified
    • Tested in MDCK model only

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the structurally defined inactive dimer-of-dimers state is dynamically regulated in cells, and how this couples to DUOXA1's trafficking and signaling roles, remains open.
  • No human DUOX1-DUOXA1 structure in the corpus
  • Physiological signal controlling oligomeric switching unknown
  • Link between apical localization and downstream ROS signaling outputs untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005886 plasma membrane 1
Pathway
R-HSA-392499 Metabolism of proteins 3 R-HSA-8953897 Cellular responses to stimuli 3
Partners
DUOX1
Complex memberships
DUOX1-DUOXA1 NADPH oxidase complex

Evidence

Reading pass · 7 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2020 Cryo-EM structures of the mouse DUOX1-DUOXA1 complex reveal atomic details of the DUOX1-DUOXA1 interaction interface, a lipid-mediated NADPH-binding pocket, and the electron transfer path. An unexpected dimer-of-dimers configuration was identified and biochemical analyses indicated this represents an inactive state, suggesting an oligomerization-dependent regulatory mechanism for DUOX1-DUOXA1. Cryo-EM structure determination (with and without NADPH substrate), biochemical analyses Nature structural & molecular biology High 32929281
2024 DUOXA1 is required for correct apical plasma membrane targeting of DUOX1 in polarized epithelial (MDCK) cells. N-glycosylation of DUOXA1 is essential for apical sorting of DUOX1; impairment of DUOXA1 N-glycosylation causes mistargeting of DUOX1 to the basolateral membrane. DUOXA2 cannot substitute for DUOXA1 in directing DUOX1 to the apical membrane. Co-expression in MDCK epithelial cells, N-glycosylation mutants, immunofluorescence localization assays Genes to cells : devoted to molecular & cellular mechanisms High 39126279
2014 DUOXA1 overexpression in murine primary myoblasts increases H2O2 production (via DUOX1), causes fusion defects, reduces expression of myogenin and myosin heavy chain differentiation markers, and elevates apoptosis. The phenotype is rescued by siRNA knockdown of DUOX1 or ASK1, placing DUOXA1 upstream of DUOX1 and ASK1 in a pathway that inhibits muscle satellite cell differentiation. Adenoviral overexpression, shRNA knockdown, siRNA rescue, H2O2 measurement, differentiation marker immunoblotting Cell communication and signaling : CCS High 24410844
2009 DUOXA1/NIP1 overexpression in MDA-MB-231 breast cancer cells increases ROS production, inhibits cell proliferation (with upregulation of p21Cip1/WAF1), downregulates cell-surface integrin αVβ5 and CD9 (impairing cell spreading), and modulates actin cytoskeleton to affect cell-cell adhesion. These effects were not observed in DUOX1-depleted cells, indicating DUOXA1 acts through DUOX1-dependent ROS. Transient transfection overexpression, DUOX1 depletion, ROS measurement, immunoblotting for p21/integrin/CD9, cell spreading assay, actin cytoskeleton imaging Breast cancer research and treatment Medium 19322654
2011 A single functional DUOXA1 allele (in the context of two functioning DUOX1 alleles but absent/defective DUOXA2) produces only mild transient hypothyroidism, demonstrating functional redundancy between DUOXA1 and DUOXA2 maturation factors. Heterodimerization with DUOXA1 or DUOXA2 is essential for maturation and function of the respective DUOX enzyme complexes. In vitro reconstitution of DUOX2/DUOXA2(C189R) loss-of-function; clinical genetic mapping of deletion; functional assay of mutant DUOXA2 The Journal of clinical endocrinology and metabolism Medium 21367925
2018 DUOXA1 overexpression in platinum-resistant ovarian cancer cells drives elevated ROS production, which sustains activation of the ATR-Chk1 DNA damage response pathway leading to cisplatin resistance. Blocking DUOXA1, ROS, ATR, or Chk1 overcomes resistance in vitro and in vivo. qHTCS screen, RNA-seq, ROS measurement, RNAi/inhibitor knockdown of DUOXA1/ATR/Chk1, in vitro and in vivo cisplatin resistance assays Cancer letters Medium 29704517
2019 A heterozygous DUOXA1 missense mutation (p.R56W) decreases DUOX1 mRNA and protein expression and correspondingly impairs H2O2 generation. The results confirm that intact DUOXA1 is required for full DUOX1 activity and H2O2 generation, establishing DUOXA1 as an essential co-factor for DUOX1-dependent H2O2 production. Direct sequencing, site-directed mutagenesis, expression analysis (mRNA and protein), H2O2 generation functional assay Frontiers in endocrinology Medium 31428054

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2021 Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures. Nucleic acids research 851 33956157
2002 A fluorimetric method for the estimation of G+C mol% content in microorganisms by thermal denaturation temperature. Environmental microbiology 633 12460286
1988 Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. The Journal of clinical investigation 568 2839545
1983 Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). The Journal of clinical investigation 355 6874946
1985 Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts. The Journal of cell biology 326 3155749
1981 B cell helper factors. I. Requirement for both interleukin 2 and another 40,000 mol wt factor. The Journal of experimental medicine 241 6795304
1985 Genetics, evolution, and expression of the 68,000-mol-wt neurofilament protein: isolation of a cloned cDNA probe. The Journal of cell biology 195 3919033
1986 Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity. The EMBO journal 165 3956481
1985 A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts. The Journal of cell biology 128 3968178
1985 Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat-shock protein in animal cell extracts. The EMBO journal 128 4018025
1984 Role of anchorin CII, a 31,000-mol-wt membrane protein, in the interaction of chondrocytes with type II collagen. The Journal of cell biology 123 6325473
1985 A 300,000-mol-wt intermediate filament-associated protein in baby hamster kidney (BHK-21) cells. The Journal of cell biology 114 3881459
1987 Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]. Molecular and cellular biology 111 3547085
1980 Widespread distribution of a 210,000 mol wt microtubule-associated protein in cells and tissues of primates. The Journal of cell biology 103 6780572
1984 A cell surface integral membrane glycoprotein of 85,000 mol wt (gp85) associated with triton X-100-insoluble cell skeleton. The Journal of cell biology 83 6378925
1996 Expression of the 27,000 mol. wt heat shock protein following kainic acid-induced status epilepticus in the rat. Neuroscience 77 8951878
1985 Antibody against acid-stable insulin-like growth factor binding protein detects 150,000 mol wt growth hormone-dependent complex in human plasma. The Journal of clinical endocrinology and metabolism 69 2411755
1985 Monoclonal antibodies to the 140,000 mol wt glycoprotein of B lymphocyte membranes (CR2 receptor) initiates proliferation of B cells in vitro. Blood 68 2931142
1985 Effects of chemotactic factors and other agents on the amounts of actin and a 65,000-mol-wt protein associated with the cytoskeleton of rabbit and human neutrophils. The Journal of cell biology 66 2989297
1982 Microtubule-associated proteins of HeLa cells: heat stability of the 200,000 mol wt HeLa MAPs and detection of the presence of MAP-2 in HeLa cell extracts and cycled microtubules. The Journal of cell biology 59 6173388
1997 The Aspergillus nidulans genes chsA and chsD encode chitin synthases which have redundant functions in conidia formation [corrected and republished article originally appeared in Mol Gen Genet 1996 Jun; 251(4):442-50]. Molecular & general genetics : MGG 57 9037115
1985 Effect upon mitogenic stimulation of calcium-dependent phosphorylation of cytoskeleton-associated 350,000- and 80,000-mol-wt polypeptides in quiescent 3Y1 cells. The Journal of cell biology 57 3972893
2018 DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer. Cancer letters 56 29704517
2011 A single copy of the recently identified dual oxidase maturation factor (DUOXA) 1 gene produces only mild transient hypothyroidism in a patient with a novel biallelic DUOXA2 mutation and monoallelic DUOXA1 deletion. The Journal of clinical endocrinology and metabolism 50 21367925
1997 Design of a leucine zipper coiled coil stabilized 1.4 kcal mol-1 by phosphorylation of a serine in the e position. Protein science : a publication of the Protein Society 50 9194187
1985 Monoclonal antibodies to a 28,000 mol. wt protein antigen of Mycobacterium leprae. Clinical and experimental immunology 50 2410167
1984 A 45,000-mol-wt protein-actin complex from unfertilized sea urchin egg affects assembly properties of actin. The Journal of cell biology 50 6470047
1984 A 45,000-mol-wt protein from unfertilized sea urchin eggs severs actin filaments in a calcium-dependent manner and increases the steady-state concentration of nonfilamentous actin. The Journal of cell biology 48 6540784
1983 Localization of the genes for the two chlorophyll a-conjugated polypeptides (mol. wt. 51 and 44 kd) of the photosystem II reaction center on the spinach plastid chromosome. The EMBO journal 47 16453486
2018 The Microencapsulation of Maqui (Aristotelia chilensis (Mol.) Stuntz) Juice by Spray-Drying and Freeze-Drying Produces Powders with Similar Anthocyanin Stability and Bioaccessibility. Molecules (Basel, Switzerland) 42 29783783
2014 Anthocyanin profiling of wild maqui berries (Aristotelia chilensis [Mol.] Stuntz) from different geographical regions in Chile. Journal of the science of food and agriculture 42 24497378
2014 Dual oxidase maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation. Cell communication and signaling : CCS 41 24410844
2000 The high molecular weight fibroblast growth factor-2 isoforms (21,000 mol. wt and 23,000 mol. wt) mediate neurotrophic activity on rat embryonic mesencephalic dopaminergic neurons in vitro. Neuroscience 40 10996460
1984 Immunohistochemical detection of the estrogen-regulated 52,000 mol wt protein in primary breast cancers but not in normal breast and uterus. The Journal of clinical endocrinology and metabolism 40 6378954
1996 Long-term expression of the 35,000 mol. wt fos-related antigen in rat brain after kainic acid treatment. Neuroscience 37 8809832
1982 Induction of hamster hepatic peroxisomal beta-oxidation and peroxisome proliferation-associated 80000 mol. wt. polypeptide by hypolipidemic drugs. Human toxicology 35 7173894
1983 Purification of the 22000- and 20000-mol.wt. forms of human somatotropin and characterization of their binding to liver and mammary binding sites. The Biochemical journal 34 6312965
2020 Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation. Nature structural & molecular biology 32 32929281
1981 Immunoelectron microscopic localization of the 210,000-mol wt microtubule-associated protein in cultured cells of primates. The Journal of cell biology 32 6118376
1999 Synaptic localization of the 67,000 mol. wt isoform of glutamate decarboxylase and transmitter function of GABA in the mouse cerebellum lacking the 65,000 mol. wt isoform. Neuroscience 25 10501472
1999 N-methyl-D-aspartate receptor 1 in the caudate-putamen nucleus: ultrastructural localization and co-expression with sorcin, a 22,000 mol. wt calcium binding protein. Neuroscience 24 10188938
2018 Distinct effects of daratumumab on indirect and direct antiglobulin tests: a new method employing 0.01 mol/L dithiothreitol for negating the daratumumab interference with preserving K antigenicity (Osaka method). Transfusion 23 30267414
2019 [1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2-induced inflammation. Acta pharmacologica Sinica 22 31729469
2001 Crystallization, melting, and enzymatic degradation of biodegradable poly(butylene succinate-co-14 mol % ethylene succinate) copolyester. Biomacromolecules 22 11749188
1986 Aberrant activation and regulation of the oxidative burst in neutrophils with Mol glycoprotein deficiency. Journal of immunology (Baltimore, Md. : 1950) 22 3013997
1990 Distribution of a gelsolin-like 74,000 mol. wt protein in neural and endocrine tissues. Neuroscience 21 2176721
1988 Reactivity of stage-specific monoclonal antibody 1G7 with metacyclic trypomastigotes of Trypanosoma cruzi strains: lytic property and 90,000 mol. wt surface antigen polymorphism. Parasite immunology 21 3050800
1984 Cell-substratum adhesion in embryonic chick central nervous system is mediated by a 170,000-mol-wt neural-specific polypeptide. The Journal of cell biology 21 6386822
2009 NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics. Breast cancer research and treatment 20 19322654
2024 Correction: Qin et al. Production and Stabilization of Specific Upregulated Long Noncoding RNA HOXD-AS2 in Glioblastomas Are Mediated by TFE3 and miR-661, Respectively. Int. J. Mol. Sci. 2022, 23, 2828. International journal of molecular sciences 18 39796287
1983 Possible heterogeneity of Streptococcus milleri determined by DNA mol % (guanine plus cytosine) measurement and physiological characterization. Microbios 18 6645981
2022 Molecular persistent spectral image (Mol-PSI) representation for machine learning models in drug design. Briefings in bioinformatics 17 34958660
2019 Identification of Two Missense Mutations in DUOX1 (p.R1307Q) and DUOXA1 (p.R56W) That Can Cause Congenital Hypothyroidism Through Impairing H2O2 Generation. Frontiers in endocrinology 16 31428054
2013 Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mammalian genome : official journal of the International Mammalian Genome Society 16 23604909
2016 Flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected. Endocrine regulations 15 27941179
2022 Correction: Yu et al. HPV16 and HPV18 Genome Structure, Expression, and Post-Transcriptional Regulation. Int. J. Mol. Sci. 2022, 23, 4943. International journal of molecular sciences 14 35887403
2019 Comment on the: Molecular mechanism of CAT and SOD activity change under MPA-CdTe quantum dots induced oxidative stress in the mouse primary hepatocytes (Spectrochim Acta A Mol Biomol Spectrosc. 2019 Sep 5; 220:117104). Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 14 31865110
1998 Immunohistochemical localization and quantification of glial fibrillary acidic protein and synaptosomal-associated protein (mol. wt 25000) in the ageing hippocampus following administration of 5,7-dihydroxytryptamine. Neuroscience 14 9607708
1988 RU486 (an anti-steroid hormone) receptor structure and heat shock protein mol. wt 90,000 (hsp 90). Human reproduction (Oxford, England) 14 3292573
2020 Targeted-dose of busulfan: Higher risk of sinusoidal obstructive syndrome observed with systemic exposure dose above 5000 µMol⸱min. A historically controlled clinical trial. Hematological oncology 12 32779746
1996 Four repeat high-mol-wt MAP2 forms in rat dorsal root ganglia. Journal of molecular neuroscience : MN 12 8906615
2022 Comment on Aldén et al. Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. Curr. Issues Mol. Biol. 2022, 44, 1115-1126. Current issues in molecular biology 11 35723371
1987 Thiol-dependent aminopeptidase (350,000 mol wt) as a marker of epidermal contamination in sweat. Journal of applied physiology (Bethesda, Md. : 1985) 10 3115946
2009 [Use of algarrobo (Prosopis chilensis (Mol) Stuntz) flour as protein and dietary fiber source in cookies and fried chips manufacture]. Archivos latinoamericanos de nutricion 8 19719017
2001 Involvement of an unusual mol operon in molybdopterin cofactor biosynthesis in Ralstonia eutropha. Journal of molecular microbiology and biotechnology 8 11545279
2024 The NADPH oxidases DUOX1 and DUOX2 are sorted to the apical plasma membrane in epithelial cells via their respective maturation factors DUOXA1 and DUOXA2. Genes to cells : devoted to molecular & cellular mechanisms 7 39126279
2014 Transferability of cucumber microsatellite markers used for phylogenetic analysis and population structure study in bottle gourd (Lagenaria siceraria (Mol.) Standl.). Applied biochemistry and biotechnology 7 25471016
1989 Extraction and identification of a 31,000 mol.wt glycoprotein antigen of Ostertagia circumcincta by sera from resistant sheep. International journal for parasitology 7 2777466
2020 Correction: Cao, Z., et al. The Expression and Functional Significance of Runx2 in Hepatocellular Carcinoma: Its Role in Vasculogenic Mimicry and Epithelial-Mesenchymal Transition. Int. J. Mol. Sci. 2017, 18, 500. International journal of molecular sciences 6 33374891
1986 The Multiple Forms of alpha-Amylase Enzyme of the Araucaria Species of South America: A. araucana (Mol.) Koch and A. angustifolia (Bert.) O. Kutz : A Comparative Study. Plant physiology 6 16664944
1983 On the possible presence of a beta 2-microglobulin-like protein in extracts of livers from normal chickens and chickens with erythroblastosis--I. Recognition of a small-molecular weight (mol. wt 11,000) protein. Comparative biochemistry and physiology. B, Comparative biochemistry 6 6187514
2024 Correction: Gabryś et al. Follicular Fluid-Derived Extracellular Vesicles Influence on In Vitro Maturation of Equine Oocyte: Impact on Cumulus Cell Viability, Expansion and Transcriptome. Int. J. Mol. Sci. 2024, 25, 3262. International journal of molecular sciences 5 39000609
2024 The Detailed Analysis of Polish Patients with Non-Small Cell Lung Cancer Through Insights from Molecular Testing (POL-MOL Study). International journal of molecular sciences 5 39518907
2019 DCA-MOL: A PyMOL Plugin To Analyze Direct Evolutionary Couplings. Journal of chemical information and modeling 5 30632747
2018 Correction: Chang, C.-H.; et al. Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression Is Associated with Tumor Grade in Head and Neck Cancer. Int. J. Mol. Sci. 2017, 18, 1556. International journal of molecular sciences 5 30096877
2004 Functional role of a high mol mass protein complex in the sea urchin yolk granule. Development, growth & differentiation 5 15066198
2000 [Use of mesquite cotyledon (Prosopis chilensis (Mol) Shuntz) in the manufacturing of cereal bars]. Archivos latinoamericanos de nutricion 5 11048586
2022 Retraction: Kannan et al. AEG-1/miR-221 Axis Cooperatively Regulates the Progression of Hepatocellular Carcinoma by Targeting PTEN/PI3K/AKT Signaling Pathway. Int. J. Mol. Sci. 2019, 20, 5526. International journal of molecular sciences 4 35708348
2022 Novel 2D photocatalyst of copper-doped carbon quantum dot CD(Cu) loaded with ultrathin Ni-MOL for degradation of tetracycline. Water science and technology : a journal of the International Association on Water Pollution Research 4 36240315
2022 Extracts of Fruits and Plants Cultivated In Vitro of Aristotelia chilensis (Mol.) Stuntz Show Inhibitory Activity of Aldose Reductase and Pancreatic Alpha-Amylase Enzymes. Plants (Basel, Switzerland) 4 36297800
2021 Crystal structure and mol-ecular docking study of (E)-2-{[(E)-2-hy-droxy-5-methyl-benzyl-idene]hydrazinyl-idene}-1,2-di-phenyl-ethan-1-one. Acta crystallographica. Section E, Crystallographic communications 4 34164147
2011 Addendum to "Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential" [Mol. Immunol. 48(4) (2011) 497-504]. Molecular immunology 4 21789793
2024 Correction: Wang et al. Role of Berberine Thermosensitive Hydrogel in Periodontitis via PI3K/AKT Pathway In Vitro. Int. J. Mol. Sci. 2023, 24, 6364. International journal of molecular sciences 3 38791609
2024 Entropy-Driven 60 mol% Li Electrolyte for Li Metal-Free Batteries. Small (Weinheim an der Bergstrasse, Germany) 3 39252636
2023 Mol-Zero-GAN: zero-shot adaptation of molecular generative adversarial network for specific protein targets. RSC advances 3 38090100
2020 Correction: Wang, Y.T., et al. Selenium Nanoparticle Synthesized by Proteus mirabilis YC801: An Efficacious Pathway for Selenite Biotransformation and Detoxification. Int. J. Mol. Sci. 2018, 19, 3809. International journal of molecular sciences 3 32290108
2020 Cytotoxicity and biocompatibility of high mol% yttria containing zirconia. Restorative dentistry & endodontics 3 33294417
2016 Retraction: Zihan Xu, et al. Tanshinone IIA Pretreatment Renders Free Flaps against Hypoxic Injury through Activating Wnt Signaling and Upregulating Stem Cell-Related Biomarkers. Int. J. Mol. Sci. 2014, 15, 18117-18130. International journal of molecular sciences 3 27213350
1992 Nuclear distribution pattern of tumour-associated nonhistone protein of mol. wt 48,000. The International journal of biochemistry 3 1592151
1982 Characterization of a 75,000 mol. wt glycoprotein synthesized by guinea-pig T-lymphocytes: a possible homologue of Lyt-1 antigen. Molecular immunology 3 6984489
2025 Visualizing and analyzing 3D biomolecular structures using Mol* at RCSB.org: Influenza A H5N1 virus proteome case study. Protein science : a publication of the Protein Society 2 40099807
2025 Intramolecular Electrochemiluminescence Resonant Energy Transfer Biosensor Utilizing Ir-Grafted 2D Hf-MOL and Circular DNA Walker for Ultrasensitive Detection of microRNA-21 in Non-Small-Cell Lung Cancer Diagnostics. Analytical chemistry 2 40448617
2025 RETRACTED: Luo et al. Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway. Int. J. Mol. Sci. 2022, 23, 9368. International journal of molecular sciences 2 41312664
2023 Mol* Volumes and Segmentations: visualization and interpretation of cell imaging data alongside macromolecular structure data and biological annotations. Nucleic acids research 2 37194693
2023 2-[3-(1H-Benzimidazol-2-yl)prop-yl]-1H-benzimidazol-3-ium 3,4,5-tri-hydroxy-benzoate-1,3-bis-(1H-benzimidazol-2-yl)propane-ethyl acetate (2/1/2.94): co-crystallization between a salt, a neutral mol-ecule and a solvent. Acta crystallographica. Section E, Crystallographic communications 2 37288461
2023 Correction: Sallam et al. DNA Methylation Alterations in Fractionally Irradiated Rats and Breast Cancer Patients Receiving Radiotherapy. Int. J. Mol. Sci. 2022, 23, 16214. International journal of molecular sciences 2 38139464
2020 Development and Inter-Laboratory Validation of Diagnostics Panel for Detection of Biothreat Bacteria Based on MOL-PCR Assay. Microorganisms 2 33374468
2019 Correlation between Phase Behavior and Electrical Conductivity of 10 mol % Y-Doped BaZrO3: An Anomalous Dispersion Effect-Aided Synchrotron Radiation XRD Study Combined with TEM Observation and Electrochemical Analysis. ACS applied materials & interfaces 2 30620169
2015 Polygenic expression of teratozoospermia and normal fertility in B10.MOL-TEN1 mouse strain. Congenital anomalies 2 25559406
2000 Development of an antibody against a 40,000 mol. wt brain injury-derived neurotrophic peptide-binding protein and identification of a 40,000 mol. wt brain injury-derived neurotrophic peptide-binding protein in hippocampal neurons. Neuroscience 2 10869850

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