Affinage

DUOXA1

Dual oxidase maturation factor 1 · UniProt Q1HG43

Length
343 aa
Mass
37.8 kDa
Annotated
2026-04-28
100 papers in source corpus 8 papers cited in narrative 8 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DUOXA1 is a transmembrane maturation factor that co-assembles with DUOX1 to form a functional NADPH oxidase complex required for reactive oxygen species (H₂O₂) generation at epithelial surfaces. Cryo-EM structures of the DUOX1–DUOXA1 complex revealed that DUOXA1 contributes a lipid-mediated NADPH-binding pocket and participates in an oligomerization-dependent regulatory mechanism in which a dimer-of-dimers configuration represents an inactive state (PMID:32929281). N-glycosylation of DUOXA1 is essential for apical plasma membrane sorting of the DUOX1–DUOXA1 complex in polarized epithelial cells, and DUOXA1 can substitute for DUOXA2 to support DUOX2-dependent thyroid hormone synthesis (PMID:39126279, PMID:21367925). Beyond its maturation role, DUOXA1-driven ROS production regulates muscle satellite cell differentiation through the DUOX1–ASK1 signaling axis and, in ovarian cancer, sustains ATR–Chk1 pathway activation contributing to cisplatin resistance (PMID:24410844, PMID:29704517).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2009 Medium

    The question of whether DUOXA1 has cellular effects beyond simply activating DUOX1 was addressed by showing that DUOXA1 overexpression in breast cancer cells increased ROS, inhibited proliferation via p21 upregulation, and altered adhesion molecules independently of DUOX1.

    Evidence Overexpression and siRNA knockdown in breast cancer cell lines with ROS assays, flow cytometry, and immunofluorescence

    PMID:19322654

    Open questions at the time
    • DUOX1-independent effects lack an identified enzymatic partner or alternative oxidase mechanism
    • single cell-line study without in vivo validation
    • mechanism linking DUOXA1 to integrin/CD9 regulation not defined
  2. 2010 High

    Whether DUOXA1 function is conserved and essential in vivo was established by Drosophila NIP null mutants, which died at 1st larval instar; lethality was rescued by NIP but not by Duox, demonstrating essential DUOX-independent functions.

    Evidence Drosophila genetic nulls, UAS-rescue experiments, RNAi, oxidative stress and mitochondrial aconitase assays

    PMID:20567495

    Open questions at the time
    • Identity of DUOX-independent molecular targets of NIP/DUOXA1 remains unknown
    • mitochondrial aconitase effect mechanism not determined
  3. 2011 Medium

    The functional redundancy between DUOXA1 and DUOXA2 within the DUOX system was quantified: a single functional DUOXA1 allele paired with two DUOX1 alleles maintained near-normal thyroid hormone synthesis, establishing that DUOXA1 can substitute for DUOXA2.

    Evidence Human genetic analysis of DUOXA2-mutant patients with in vitro reconstitution

    PMID:21367925

    Open questions at the time
    • Study based on limited patient cohort
    • precise structural determinants of DUOXA1/DUOXA2 interchangeability not defined
  4. 2014 High

    The signaling axis downstream of DUOXA1-generated ROS was placed by epistasis: DUOXA1 overexpression in muscle satellite cells inhibited differentiation through DUOX1-dependent H₂O₂ and ASK1, establishing DUOXA1 as an upstream regulator of ROS-mediated myogenic signaling.

    Evidence Adenoviral overexpression, siRNA epistasis for DUOX1 and ASK1, H₂O₂ quantification, myogenic marker assays in murine satellite cells

    PMID:24410844

    Open questions at the time
    • Physiological context of DUOXA1 regulation in muscle regeneration not established
    • downstream targets of ASK1 in this pathway not identified
  5. 2018 Medium

    A pathological role for DUOXA1-driven ROS was defined in platinum-resistant ovarian cancer, where DUOXA1 sustains ATR–Chk1 checkpoint activation; inhibiting any node (DUOXA1, ROS, ATR, Chk1) overcame resistance.

    Evidence RNA-seq, high-throughput drug screen, ROS measurement, siRNA/shRNA knockdown, xenograft models

    PMID:29704517

    Open questions at the time
    • Mechanism by which DUOXA1-derived ROS specifically activates ATR rather than other DNA-damage sensors not resolved
    • single lab study without independent cohort validation
  6. 2019 Medium

    Direct structure–function evidence for DUOXA1 in DUOX1 activation was provided by the p.R56W missense mutation, which reduced both DUOXA1 expression and DUOX1-mediated H₂O₂ generation, confirming intact DUOXA1 is required for full DUOX1 enzymatic activity.

    Evidence Patient mutation identification with in vitro H₂O₂ generation and expression assays

    PMID:31428054

    Open questions at the time
    • Structural basis for how R56W destabilizes DUOXA1 not determined
    • single patient-derived mutation
  7. 2020 High

    The atomic mechanism of DUOXA1 function was resolved: cryo-EM structures showed DUOXA1 contributes a lipid-mediated NADPH-binding interface, defines the electron transfer pathway through DUOX1, and revealed an oligomerization-dependent inactive dimer-of-dimers state as a regulatory mechanism.

    Evidence Cryo-EM at multiple conformational states (active, substrate-bound, dimer-of-dimers) with biochemical validation

    PMID:32929281

    Open questions at the time
    • Physiological signals that switch between active heterodimer and inactive dimer-of-dimers states are unknown
    • identity and role of the specific lipid cofactor in vivo not established
  8. 2024 High

    The trafficking role of DUOXA1 was defined: N-glycosylation of DUOXA1 is essential for apical targeting of the DUOX1–DUOXA1 complex, as glycosylation-defective mutants mislocalize to the basolateral membrane.

    Evidence Co-expression of WT and glycosylation-defective DUOXA1 mutants with DUOX1 in polarized MDCK cells, subcellular localization imaging

    PMID:39126279

    Open questions at the time
    • Glycan structures and sorting receptors responsible for apical targeting not identified
    • whether this mechanism applies in native thyroid or airway epithelium in vivo not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the identity of DUOX-independent molecular targets of DUOXA1, the physiological signals regulating the active-to-inactive oligomeric switch, and the specific lipid and glycan species mediating DUOXA1 cofactor and trafficking functions.
  • DUOX-independent functions have no identified molecular partners or substrates
  • in vivo regulation of dimer-of-dimers transition unknown
  • structural basis for DUOXA1/DUOXA2 functional interchangeability not resolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0060090 molecular adaptor activity 2
Localization
GO:0005886 plasma membrane 2
Pathway
GO:0016491 oxidoreductase activity 3 R-HSA-162582 Signal Transduction 2 R-HSA-1643685 Disease 1
Partners
DUOX1DUOX2MAP3K5
Complex memberships
DUOX1-DUOXA1 complexDUOX2-DUOXA1 complex

Evidence

Reading pass · 8 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2020 Cryo-EM structures of the mammalian DUOX1-DUOXA1 complex (with and without NADPH substrate, and in a dimer-of-dimers configuration) revealed atomic details of DUOX1-DUOXA1 interaction, a lipid-mediated NADPH-binding pocket, the electron transfer path, and an oligomerization-dependent regulatory mechanism in which the dimer-of-dimers configuration represents an inactive state. Cryo-EM structural determination with biochemical validation Nature structural & molecular biology High 32929281
2024 DUOXA1 is required for apical plasma membrane sorting of DUOX1 in epithelial cells; N-glycosylation of DUOXA1 is essential for this apical targeting, as glycosylation-defective DUOXA1 causes DUOX1 to mislocalize to the basolateral membrane. Epithelial cell (MDCK) co-expression with wild-type and glycosylation-defective DUOXA1 mutants, subcellular localization imaging Genes to cells : devoted to molecular & cellular mechanisms High 39126279
2011 DUOXA1 functions as a maturation factor essential for DUOX2 (and by extension DUOX1) enzyme complex activity; a single functional DUOXA1 allele (with two functional DUOX1 alleles) is sufficient to maintain near-normal thyroid hormone synthesis, demonstrating high functional redundancy within the DUOX/DUOXA system. Human genetic analysis with in vitro reconstitution of DUOXA2 mutant loss-of-function The Journal of clinical endocrinology and metabolism Medium 21367925
2014 DUOXA1 overexpression in murine muscle satellite cells increases H2O2 production and inhibits myoblast differentiation through DUOX1 and apoptosis signal-regulating kinase 1 (ASK1); siRNA knockdown of DUOX1 or ASK1 rescued the differentiation defect caused by DUOXA1 overexpression, placing DUOXA1 upstream of DUOX1 and ASK1 in this pathway. Adenoviral overexpression, shRNA knockdown, siRNA epistasis analysis, H2O2 measurement, myogenic marker expression assays Cell communication and signaling : CCS High 24410844
2018 DUOXA1 overexpression in platinum-resistant ovarian cancer cells produces elevated ROS that sustains ATR-Chk1 pathway activation, contributing to cisplatin resistance; inhibiting DUOXA1, ROS, ATR, or Chk1 overcame resistance in vitro and in vivo. RNA-seq, quantitative high-throughput combinational screen, ROS measurement, in vitro and in vivo inhibitor studies, siRNA/shRNA knockdown Cancer letters Medium 29704517
2009 DUOXA1/NIP1 overexpression in breast cancer cells increases ROS generation, inhibits cell proliferation via p21(Cip1/WAF1) upregulation, reduces integrin αVβ5 and CD9 surface expression, impairs cell spreading, and modulates actin cytoskeleton and cell-cell adhesion; these effects were not observed with DUOX1 depletion alone, indicating DUOXA1 has functions independent of DUOX1. Transient transfection overexpression, ROS assay, flow cytometry, immunofluorescence, siRNA knockdown Breast cancer research and treatment Medium 19322654
2010 NIP/DuoxA (Drosophila ortholog of DUOXA1) is essential for Drosophila development; null mutants die at the 1st larval instar and this lethality is rescued by UAS-nip but not UAS-Duox expression, demonstrating NIP has functions beyond simply activating Duox. Ubiquitous RNAi-mediated silencing of nip caused developmental abnormalities, reduced lifespan, impaired survival under oxidative stress, and reduced mitochondrial aconitase function. Drosophila genetic null mutants, UAS-rescue experiments, RNAi knockdown, oxidative stress assays, mitochondrial aconitase activity measurement International journal of biological sciences High 20567495
2019 A DUOXA1 missense mutation (p.R56W) decreases DUOXA1 expression at both mRNA and protein levels and impairs DUOX1-mediated H2O2 generation; intact DUOXA1 is required for full DUOX1 enzymatic activity. Patient mutation identification, in vitro functional assay of H2O2 generation, expression analysis Frontiers in endocrinology Medium 31428054

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2021 Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures. Nucleic acids research 821 33956157
2002 A fluorimetric method for the estimation of G+C mol% content in microorganisms by thermal denaturation temperature. Environmental microbiology 633 12460286
1983 Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). The Journal of clinical investigation 355 6874946
1985 Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts. The Journal of cell biology 326 3155749
1966 Chemical and serological studies with an iodine-containing synthetic immunological determinant 4-hydroxy-3-iodo-5-nitrophenylacetic acid (NIP) and related compounds. Immunology 271 5939478
1981 B cell helper factors. I. Requirement for both interleukin 2 and another 40,000 mol wt factor. The Journal of experimental medicine 241 6795304
1991 The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions. Clinical and experimental immunology 160 1707767
1985 A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts. The Journal of cell biology 128 3968178
2007 Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (Cambridge, England) 125 17215306
1984 Role of anchorin CII, a 31,000-mol-wt membrane protein, in the interaction of chondrocytes with type II collagen. The Journal of cell biology 123 6325473
1985 A 300,000-mol-wt intermediate filament-associated protein in baby hamster kidney (BHK-21) cells. The Journal of cell biology 114 3881459
1980 Widespread distribution of a 210,000 mol wt microtubule-associated protein in cells and tissues of primates. The Journal of cell biology 103 6780572
1984 A cell surface integral membrane glycoprotein of 85,000 mol wt (gp85) associated with triton X-100-insoluble cell skeleton. The Journal of cell biology 83 6378925
2004 Identification and characterization of Nip, necrosis-inducing virulence protein of Erwinia carotovora subsp. carotovora. Molecular plant-microbe interactions : MPMI 78 15597742
1996 Expression of the 27,000 mol. wt heat shock protein following kainic acid-induced status epilepticus in the rat. Neuroscience 77 8951878
2004 nip, a symbiotic Medicago truncatula mutant that forms root nodules with aberrant infection threads and plant defense-like response. Plant physiology 76 15516506
1985 Antibody against acid-stable insulin-like growth factor binding protein detects 150,000 mol wt growth hormone-dependent complex in human plasma. The Journal of clinical endocrinology and metabolism 69 2411755
1972 Immunity tolerance to a hapten (NIP) coupled to an isologous carrier (mouse gamma globulin). The Journal of experimental medicine 62 4115131
2012 Functional assessment of the Medicago truncatula NIP/LATD protein demonstrates that it is a high-affinity nitrate transporter. Plant physiology 60 22858636
2017 Monodispersed Carbon-Coated Cubic NiP2 Nanoparticles Anchored on Carbon Nanotubes as Ultra-Long-Life Anodes for Reversible Lithium Storage. ACS nano 58 28323408
1997 The Aspergillus nidulans genes chsA and chsD encode chitin synthases which have redundant functions in conidia formation [corrected and republished article originally appeared in Mol Gen Genet 1996 Jun; 251(4):442-50]. Molecular & general genetics : MGG 57 9037115
1985 Effect upon mitogenic stimulation of calcium-dependent phosphorylation of cytoskeleton-associated 350,000- and 80,000-mol-wt polypeptides in quiescent 3Y1 cells. The Journal of cell biology 57 3972893
2018 DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer. Cancer letters 53 29704517
2003 Members of the aquaporin family in the developing pea seed coat include representatives of the PIP, TIP, and NIP subfamilies. Plant molecular biology 52 15010602
2011 A single copy of the recently identified dual oxidase maturation factor (DUOXA) 1 gene produces only mild transient hypothyroidism in a patient with a novel biallelic DUOXA2 mutation and monoallelic DUOXA1 deletion. The Journal of clinical endocrinology and metabolism 50 21367925
1997 Design of a leucine zipper coiled coil stabilized 1.4 kcal mol-1 by phosphorylation of a serine in the e position. Protein science : a publication of the Protein Society 50 9194187
1985 Monoclonal antibodies to a 28,000 mol. wt protein antigen of Mycobacterium leprae. Clinical and experimental immunology 50 2410167
1984 A 45,000-mol-wt protein-actin complex from unfertilized sea urchin egg affects assembly properties of actin. The Journal of cell biology 50 6470047
1984 A 45,000-mol-wt protein from unfertilized sea urchin eggs severs actin filaments in a calcium-dependent manner and increases the steady-state concentration of nonfilamentous actin. The Journal of cell biology 48 6540784
1983 Localization of the genes for the two chlorophyll a-conjugated polypeptides (mol. wt. 51 and 44 kd) of the photosystem II reaction center on the spinach plastid chromosome. The EMBO journal 47 16453486
2011 Mechanisms and biology of B-cell leukemia/lymphoma 2/adenovirus E1B interacting protein 3 and Nip-like protein X. Antioxidants & redox signaling 44 21126215
2022 Tumorigenicity risk of iPSCs in vivo: nip it in the bud. Precision clinical medicine 42 35692443
2018 The Microencapsulation of Maqui (Aristotelia chilensis (Mol.) Stuntz) Juice by Spray-Drying and Freeze-Drying Produces Powders with Similar Anthocyanin Stability and Bioaccessibility. Molecules (Basel, Switzerland) 42 29783783
2014 Anthocyanin profiling of wild maqui berries (Aristotelia chilensis [Mol.] Stuntz) from different geographical regions in Chile. Journal of the science of food and agriculture 42 24497378
2000 The high molecular weight fibroblast growth factor-2 isoforms (21,000 mol. wt and 23,000 mol. wt) mediate neurotrophic activity on rat embryonic mesencephalic dopaminergic neurons in vitro. Neuroscience 40 10996460
1984 Immunohistochemical detection of the estrogen-regulated 52,000 mol wt protein in primary breast cancers but not in normal breast and uterus. The Journal of clinical endocrinology and metabolism 40 6378954
2014 Dual oxidase maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation. Cell communication and signaling : CCS 39 24410844
1996 Long-term expression of the 35,000 mol. wt fos-related antigen in rat brain after kainic acid treatment. Neuroscience 37 8809832
2005 Atria selective prolongation by NIP-142, an antiarrhythmic agent, of refractory period and action potential duration in guinea pig myocardium. Journal of pharmacological sciences 36 15879679
2006 Blockade by NIP-142, an antiarrhythmic agent, of carbachol-induced atrial action potential shortening and GIRK1/4 channel. Journal of pharmacological sciences 33 16891768
1981 Immunoelectron microscopic localization of the 210,000-mol wt microtubule-associated protein in cultured cells of primates. The Journal of cell biology 32 6118376
2020 Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation. Nature structural & molecular biology 31 32929281
2020 Efficient and Stable Planar n-i-p Sb2Se3 Solar Cells Enabled by Oriented 1D Trigonal Selenium Structures. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 29 32832357
2023 Sessile serrated lesions with dysplasia: is it possible to nip them in the bud? Journal of gastroenterology 26 37219625
2024 'Nip it in the bud': Low-frequency rTMS of the prefrontal cortex disrupts threat memory consolidation in humans. Behaviour research and therapy 25 38704974
1999 Synaptic localization of the 67,000 mol. wt isoform of glutamate decarboxylase and transmitter function of GABA in the mouse cerebellum lacking the 65,000 mol. wt isoform. Neuroscience 25 10501472
2010 Control of root architecture and nodulation by the LATD/NIP transporter. Plant signaling & behavior 24 21045559
2008 Biomimetic cleavage of RNA models promoted by a dinuclear Zn(II) complex in ethanol. Greater than 30 kcal/mol stabilization of the transition state for cleavage of a phosphate diester. Journal of the American Chemical Society 22 19554695
2002 Effects of NIP-141 on K currents in human atrial myocytes. Journal of cardiovascular pharmacology 22 11743225
1991 Accumulation of p60lck in HTLV-I-transformed T cell lines detected by an anti-lck monoclonal antibody, MOL 171. Japanese journal of cancer research : Gann 22 1910028
2019 [1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2-induced inflammation. Acta pharmacologica Sinica 21 31729469
2008 Cisplatin-based three drugs combination (NIP) as induction and adjuvant treatment in locally advanced non-small cell lung cancer: final results. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 21 18303436
1990 Distribution of a gelsolin-like 74,000 mol. wt protein in neural and endocrine tissues. Neuroscience 21 2176721
1988 Reactivity of stage-specific monoclonal antibody 1G7 with metacyclic trypomastigotes of Trypanosoma cruzi strains: lytic property and 90,000 mol. wt surface antigen polymorphism. Parasite immunology 21 3050800
1984 Cell-substratum adhesion in embryonic chick central nervous system is mediated by a 170,000-mol-wt neural-specific polypeptide. The Journal of cell biology 21 6386822
2009 NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics. Breast cancer research and treatment 19 19322654
1983 Possible heterogeneity of Streptococcus milleri determined by DNA mol % (guanine plus cytosine) measurement and physiological characterization. Microbios 18 6645981
2022 Molecular persistent spectral image (Mol-PSI) representation for machine learning models in drug design. Briefings in bioinformatics 17 34958660
2013 Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mammalian genome : official journal of the International Mammalian Genome Society 16 23604909
2019 Identification of Two Missense Mutations in DUOX1 (p.R1307Q) and DUOXA1 (p.R56W) That Can Cause Congenital Hypothyroidism Through Impairing H2O2 Generation. Frontiers in endocrinology 15 31428054
1975 Antigen-initiated B-lymphocyte differentiation. VII. Quantification of AFC progenitor levels in adoptive and culture responses to NIP-POL antigen. Immunology 15 1081490
2022 Rare complications of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis: Time to nip them in the bud. Frontiers in immunology 14 36275649
2019 Comment on the: Molecular mechanism of CAT and SOD activity change under MPA-CdTe quantum dots induced oxidative stress in the mouse primary hepatocytes (Spectrochim Acta A Mol Biomol Spectrosc. 2019 Sep 5; 220:117104). Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 14 31865110
2013 Nip the HPV encoded evil in the cancer bud: HPV reshapes TRAILs and signaling landscapes. Cancer cell international 14 23773282
1987 Interactions of NIP-taurine, NAP-taurine, and Cl- with the human erythrocyte anion exchange system. The American journal of physiology 14 3688213
2018 Perovskite solar cells in N-I-P structure with four slot-die-coated layers. Royal Society open science 13 29892402
2022 The necrosis-inducing protein (NIP) gene contributes to Penicillium expansum virulence during postharvest pear infection. Food research international (Ottawa, Ont.) 12 35840251
2010 NIP/DuoxA is essential for Drosophila embryonic development and regulates oxidative stress response. International journal of biological sciences 12 20567495
1996 Four repeat high-mol-wt MAP2 forms in rat dorsal root ganglia. Journal of molecular neuroscience : MN 12 8906615
2025 Overcoming optical losses in thin metal-based recombination layers for efficient n-i-p perovskite-organic tandem solar cells. Nature communications 11 39747017
2022 Comment on Aldén et al. Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. Curr. Issues Mol. Biol. 2022, 44, 1115-1126. Current issues in molecular biology 11 35723371
2020 Targeted-dose of busulfan: Higher risk of sinusoidal obstructive syndrome observed with systemic exposure dose above 5000 µMol⸱min. A historically controlled clinical trial. Hematological oncology 10 32779746
2016 Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-κB-mediated cytokine production. Biochemical and biophysical research communications 10 27998764
2003 A novel peroxisome proliferator-activated receptor (PPAR)gamma agonist, NIP-222, reduces urinary albumin excretion in streptozotocin-diabetic mice independent of PPARgamma activation. Metabolism: clinical and experimental 10 14669169
1994 Inhibitory properties of NIP-121, a potassium channel opener, on high potassium- and norepinephrine-induced contraction and calcium mobilization in rat aorta. Journal of cardiovascular pharmacology 10 7898070
2022 Superhydrophilic/Superaerophobic Hierarchical NiP2@MoO2/Co(Ni)MoO4 Core-Shell Array Electrocatalysts for Efficient Hydrogen Production at Large Current Densities. ACS applied materials & interfaces 9 35469395
2025 Hole-selective Transparent In Situ Passivation Contacts for Efficient and Stable n-i-p Graded Perovskite/Silicon Tandem Solar Cells. Advanced materials (Deerfield Beach, Fla.) 8 40026001
2022 Mo propellant boosting the activity of Ni-P for efficient urea-assisted water electrolysis of hydrogen evolution. Journal of colloid and interface science 8 35500324
2014 Engineering microstructure and redox properties in the mixed conductor Ce(0.9)Pr(0.1)O(2-δ) + Co 2 mol%. Dalton transactions (Cambridge, England : 2003) 8 24141898
2012 Allelic differences in Medicago truncatula NIP/LATD mutants correlate with their encoded proteins' transport activities in planta. Plant signaling & behavior 8 23154505
2009 [Use of algarrobo (Prosopis chilensis (Mol) Stuntz) flour as protein and dietary fiber source in cookies and fried chips manufacture]. Archivos latinoamericanos de nutricion 8 19719017
2001 Involvement of an unusual mol operon in molybdopterin cofactor biosynthesis in Ralstonia eutropha. Journal of molecular microbiology and biotechnology 8 11545279
2024 Lattice Matching Anchoring of Hole-Selective Molecule on Halide Perovskite Surfaces for n-i-p Solar Cells. Advanced materials (Deerfield Beach, Fla.) 7 39604293
2021 Novel Genomic Regions of Fusarium Wilt Resistance in Bottle Gourd [Lagenaria siceraria (Mol.) Standl.] Discovered in Genome-Wide Association Study. Frontiers in plant science 7 34025697
2021 An efficient Ni-P amorphous alloy electrocatalyst with a hierarchical structure toward borohydride oxidation. Dalton transactions (Cambridge, England : 2003) 7 34231614
2014 Transferability of cucumber microsatellite markers used for phylogenetic analysis and population structure study in bottle gourd (Lagenaria siceraria (Mol.) Standl.). Applied biochemistry and biotechnology 7 25471016
2024 In-Situ Cyclized Polyacrylonitrile as an Electron Selective Layer for n-i-p Perovskite Solar Cell with Enhanced Efficiency and Stability. Angewandte Chemie (International ed. in English) 6 38659076
2024 The NADPH oxidases DUOX1 and DUOX2 are sorted to the apical plasma membrane in epithelial cells via their respective maturation factors DUOXA1 and DUOXA2. Genes to cells : devoted to molecular & cellular mechanisms 6 39126279
2019 Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2). Scientific reports 6 31666531
1986 The Multiple Forms of alpha-Amylase Enzyme of the Araucaria Species of South America: A. araucana (Mol.) Koch and A. angustifolia (Bert.) O. Kutz : A Comparative Study. Plant physiology 6 16664944
2024 Correction: Gabryś et al. Follicular Fluid-Derived Extracellular Vesicles Influence on In Vitro Maturation of Equine Oocyte: Impact on Cumulus Cell Viability, Expansion and Transcriptome. Int. J. Mol. Sci. 2024, 25, 3262. International journal of molecular sciences 5 39000609
2016 NIP-SNAP-1 and -2 mitochondrial proteins are maintained by heat shock protein 60. Biochemical and biophysical research communications 5 28011268
2004 Functional role of a high mol mass protein complex in the sea urchin yolk granule. Development, growth & differentiation 5 15066198
2024 The Detailed Analysis of Polish Patients with Non-Small Cell Lung Cancer Through Insights from Molecular Testing (POL-MOL Study). International journal of molecular sciences 4 39518907
2022 Retraction: Kannan et al. AEG-1/miR-221 Axis Cooperatively Regulates the Progression of Hepatocellular Carcinoma by Targeting PTEN/PI3K/AKT Signaling Pathway. Int. J. Mol. Sci. 2019, 20, 5526. International journal of molecular sciences 4 35708348
2022 Extracts of Fruits and Plants Cultivated In Vitro of Aristotelia chilensis (Mol.) Stuntz Show Inhibitory Activity of Aldose Reductase and Pancreatic Alpha-Amylase Enzymes. Plants (Basel, Switzerland) 4 36297800
2021 Crystal structure and mol-ecular docking study of (E)-2-{[(E)-2-hy-droxy-5-methyl-benzyl-idene]hydrazinyl-idene}-1,2-di-phenyl-ethan-1-one. Acta crystallographica. Section E, Crystallographic communications 4 34164147
2020 Probing the trap states in N-i-P Sb2(S,Se)3 solar cells by deep-level transient spectroscopy. The Journal of chemical physics 4 33003708
2013 Correction: Wiedmann, M., et al. Exploration of the Role of the Non-Coding RNA SbrE in L. monocytogenes Stress Response. Int. J. Mol. Sci. 2013, 14, 378-393. International journal of molecular sciences 4 23644892
2009 [Development of a cookie formulation for celiac people using defatted Chilean hazel nut (Gevuina avellana. Mol) flour and quinoa (Chenopodium quinoa Willd) flour]. Archivos latinoamericanos de nutricion 4 19719016