Affinage

DEPP1

Protein DEPP1 · UniProt Q9NTK1

Length
212 aa
Mass
23.4 kDa
Annotated
2026-04-28
100 papers in source corpus 11 papers cited in narrative 11 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DEPP1 is a stress-inducible peroxisomal and mitochondrial protein that links hypoxia and FOXO3 signaling to organelle-selective autophagy and metabolic reprogramming by elevating cellular reactive oxygen species. It is transcriptionally induced by HIF and FOXO3 (and suppressed by insulin), localizes to peroxisomes via an N-terminal PTS2 signal recognized by the import receptor PEX7, and impairs catalase-dependent ROS detoxification; the resulting ROS accumulation drives autophagosome formation—including BNIP3-dependent mitophagy—as demonstrated by chemical rescue with N-acetyl-cysteine (PMID:25261981, PMID:28545464, PMID:34997944). DEPP1-induced ROS also activate the Ras/Raf/MEK/ERK cascade, promoting cellular senescence and, in the liver, FGF21-dependent fatty acid oxidation and ketogenesis (PMID:29440765, PMID:29702025, PMID:29749481). In cardiomyocytes, DEPP1 is both necessary and sufficient for HIF-induced mitochondrial and peroxisomal autophagy and triglyceride accumulation, and whole-body Depp1 knockout ameliorates cardiac dysfunction in a mouse model of chronic HIF activation (PMID:38881449).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2005 Medium

    Initial cloning established that DEPP1 is not merely a decidualization marker but an active signaling molecule capable of engaging the ERK/Elk-1 pathway, raising the question of its upstream inputs and downstream consequences.

    Evidence Overexpression in HEK293 cells with ERK phosphorylation and Elk-1 reporter assays

    PMID:16123073

    Open questions at the time
    • No endogenous loss-of-function data
    • Mechanism of ERK activation unknown
    • No binding partner or direct substrate identified
  2. 2009 Medium

    Identification of insulin as a negative regulator and fasting as a positive regulator of DEPP1 expression placed the gene within nutrient-sensing circuitry, though the downstream metabolic consequences remained undefined.

    Evidence Northern blot across tissues and cell lines, fasting/refeeding and streptozotocin diabetic mouse models

    PMID:19937567

    Open questions at the time
    • No mechanism linking insulin signaling to DEPP1 promoter
    • Functional consequence of DEPP1 induction during fasting not tested
  3. 2011 Medium

    Mapping of two functional FoxO-responsive elements in the DEPP1 promoter resolved how hypoxia and stress transcriptionally upregulate the gene, establishing DEPP1 as a direct FOXO transcriptional target.

    Evidence Promoter-luciferase reporters with site mutagenesis, FoxO knockdown/overexpression under normoxia and hypoxia in EA.hy926 endothelial cells

    PMID:21510935

    Open questions at the time
    • HIF-responsive elements not yet mapped
    • No chromatin immunoprecipitation to confirm direct FoxO occupancy
  4. 2014 High

    Determining that DEPP1 localizes to peroxisomes via PTS2/PEX7 and to mitochondria, and that it impairs catalase activity to elevate ROS, provided the first mechanistic explanation for its cellular function and linked it to organelle-level redox control.

    Evidence Confocal microscopy of EYFP-tagged DEPP1, co-immunoprecipitation with PEX7, catalase activity assays, gain- and loss-of-function in neuroblastoma cells

    PMID:25261981

    Open questions at the time
    • Molecular mechanism by which DEPP1 inhibits catalase (direct binding vs. indirect) unclear
    • Relative functional importance of peroxisomal vs. mitochondrial pools not resolved
  5. 2014 Medium

    Demonstration that DEPP1 overexpression activates autophagy and that silencing attenuates it established autophagy induction as a major downstream output, though the signaling intermediary (ROS) was not yet proven.

    Evidence Autophagy modulation with 3-methyladenine and rapamycin, siRNA knockdown, EC-SOD overexpression mouse model, proteasome inhibitor treatment

    PMID:24530860

    Open questions at the time
    • Causal role of ROS in DEPP1-driven autophagy not directly tested
    • Selectivity of autophagy (mitophagy vs. bulk) uncharacterized
  6. 2017 High

    Chemical rescue with N-acetyl-cysteine proved that ROS accumulation is the obligate intermediary between DEPP1 and autophagosome formation, closing the mechanistic gap between peroxisomal catalase inhibition and autophagy activation.

    Evidence Live-cell LC3 imaging, ROS measurement, NAC rescue, siRNA epistasis across starvation and genotoxic stress in neuroblastoma cells

    PMID:28545464

    Open questions at the time
    • Identity of the ROS sensor linking peroxisomal ROS to autophagy machinery unknown
    • Whether mitophagy specifically requires DEPP1-ROS axis not tested
  7. 2018 Medium

    Three studies collectively expanded the functional repertoire of DEPP1 beyond autophagy: hepatic DEPP1 drives FGF21-dependent fatty acid oxidation and ketogenesis; DEPP1 activates Ras/ERK to induce senescence; and a DEPP1→MAPK→Gadd45a feedback loop promotes apoptosis—all converging on ROS as the common upstream signal.

    Evidence Adenovirus-mediated hepatic overexpression with FGF21 antibody neutralization in mice; ectopic expression and siRNA in HCT116 with SA-β-Gal, MAPK blots, and kinase inhibitor epistasis; xenograft models

    PMID:29440765 PMID:29702025 PMID:29749481

    Open questions at the time
    • FGF21 mediates fatty acid oxidation but not gluconeogenesis effects—alternate pathway unidentified
    • Direct physical interaction between DEPP1 and Ras/Raf components not established
    • Relative contributions of ERK vs. JNK/p38 to different DEPP1 phenotypes unclear
  8. 2022 High

    DEPP1 knockout mice with surgically induced osteoarthritis showed exacerbated cartilage degradation, establishing DEPP1 as a physiologically relevant stress-protective factor and identifying BNIP3 as the downstream effector coupling DEPP1 to mitophagy in chondrocytes.

    Evidence DEPP1-knockout mice with destabilized medial meniscus model, autophagic flux measurement, BNIP3 epistasis, TUNEL assay

    PMID:34997944

    Open questions at the time
    • Whether BNIP3 upregulation is a direct ROS effect or requires transcriptional intermediaries unknown
    • Peroxisomal autophagy contribution in chondrocytes not assessed
  9. 2024 High

    CRISPR knockout of Depp1 in mice demonstrated that DEPP1 is necessary and sufficient for HIF-induced mitochondrial and peroxisomal autophagy and triglyceride accumulation in cardiomyocytes, and that its loss ameliorates cardiac dysfunction under chronic HIF activation, positioning DEPP1 as a central mediator of ischemic cardiomyopathy pathology.

    Evidence Whole-body CRISPR-Cas9 Depp1 knockout crossed with cardiac VHL-knockout mice, organelle-specific autophagy flux, RNA-seq, live-cell imaging of cardiomyocytes

    PMID:38881449

    Open questions at the time
    • Mitochondrial import mechanism of DEPP1 not resolved
    • Molecular basis of triglyceride accumulation downstream of DEPP1 not defined
    • Whether cardiac phenotype rescue is cell-autonomous to cardiomyocytes not formally demonstrated with conditional knockout

Open questions

Synthesis pass · forward-looking unresolved questions
  • The direct molecular mechanism by which DEPP1 inhibits catalase—whether through physical binding, post-translational modification, or displacement from peroxisomes—remains unresolved, as does the identity of the ROS sensor that couples DEPP1-elevated ROS to autophagy initiation machinery.
  • No structural or biochemical reconstitution of DEPP1-catalase interaction
  • ROS sensor or adaptor linking peroxisomal ROS to autophagosome nucleation unknown
  • Tissue-specific differences in DEPP1 function (cardiac vs. hepatic vs. chondrocyte) not mechanistically explained

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3
Localization
GO:0005739 mitochondrion 2 GO:0005777 peroxisome 2
Pathway
R-HSA-8953897 Cellular responses to stimuli 4 R-HSA-9612973 Autophagy 4 R-HSA-162582 Signal Transduction 3 R-HSA-1430728 Metabolism 2
Partners
BNIP3FGF21GADD45APEX7

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 DEPP (decidual protein induced by progesterone) was cloned from human endometrial stromal cell cDNA library; it increases phosphorylated ERK levels and activates the Elk-1 transcription factor in HEK293 cells, placing DEPP upstream of ERK/Elk-1 signaling during decidualization. Overexpression in HEK293 cells, ERK phosphorylation assay, Elk-1 reporter assay Molecular human reproduction Medium 16123073
2011 DEPP expression in human endothelial cells is transcriptionally regulated by FoxO transcription factors via two functional FoxO-responsive elements identified in the DEPP promoter; hypoxia-induced DEPP upregulation is FoxO-dependent. Reporter assay (DEPP promoter-luciferase), FoxO knockdown/overexpression, hypoxia treatment in EA.hy926 cells FEBS letters Medium 21510935
2014 DEPP localizes to peroxisomes and mitochondria in neuroblastoma cells via an N-terminal peroxisomal-targeting-signal-type-2 (PTS2) sequence; it directly binds the PEX7 peroxisomal import receptor (co-immunoprecipitation); DEPP overexpression reduces catalase activity and elevates ROS, while knockdown increases catalase activity and PPARG expression, establishing DEPP as an impairment of peroxisomal ROS detoxification. Confocal microscopy of EYFP-tagged DEPP with peroxisomal/mitochondrial probes, co-immunoprecipitation with PEX7, catalase activity assay, siRNA knockdown, conditional overexpression Molecular cancer High 25261981
2014 DEPP is a major hypoxia-inducible gene regulated by oxidative stress (EC-SOD); overexpressed DEPP co-localizes with protein aggregates/aggresomes and is rapidly degraded by the proteasome; DEPP overexpression activates autophagy, and DEPP silencing attenuates autophagy, linking DEPP to the autophagy pathway. Subcellular fractionation, immunofluorescence microscopy, proteasome inhibitor treatment, autophagy modulation (3-methyladenine, rapamycin), siRNA knockdown, EC-SOD overexpression mouse model Biochimica et biophysica acta Medium 24530860
2017 DEPP mediates FOXO3-induced autophagy in neuroblastoma by inducing ROS accumulation; DEPP knockdown is sufficient to block autophagy under serum starvation and genotoxic stress, and N-acetyl-cysteine (ROS scavenger) fully blocks DEPP-induced autophagosome formation, positioning ROS accumulation as the mechanistic link between DEPP and autophagy. Live-cell fluorescence microscopy (EYFP-LC3), immunoblot (LC3), ROS measurement (MitoTracker Red), siRNA knockdown of DEPP and LC3, N-acetyl-cysteine treatment, flow cytometry Molecular cancer High 28545464
2018 Ectopic DEPP expression in HCT116 colon cancer cells activates Ras/Raf/MEK/ERK and p16INK4A/Rb signaling pathways and induces cellular senescence (SA-β-Gal activity); DEPP knockdown counteracts drug-induced senescence, growth inhibition, and cell cycle arrest, establishing DEPP as a positive regulator of RAS/ERK-driven senescence. Ectopic overexpression, siRNA knockdown, SA-β-Gal assay, Western blot for pathway components, xenograft mouse model Cell death & disease Medium 29440765
2018 Hepatic overexpression of DEPP in mice promotes fatty acid oxidation and ketogenesis and suppresses lipogenesis and gluconeogenesis; DEPP increases hepatic ROS by impairing the ROS scavenging system; FGF21, upregulated in response to DEPP-induced oxidative stress, mediates the effects of DEPP on fatty acid oxidation, ketogenesis and lipid synthesis (but not gluconeogenesis), as shown by FGF21 antibody blockade. Adenovirus-mediated hepatic overexpression in mice, indirect calorimetry, biochemical assays (liver TG, glycogen, β-hydroxybutyrate), catalase activity assay, live-cell ROS fluorescence, qPCR, FGF21 antibody neutralization, db/db mouse model FASEB journal High 29702025
2009 DEPP mRNA is highly expressed in white adipose tissue and is regulated by insulin: insulin treatment significantly decreases DEPP mRNA in 3T3-L1 adipocytes, rat H4IIE, and human HepG2 hepatoma cells; fasting induces and refeeding suppresses hepatic/adipose DEPP expression in vivo, identifying insulin as a negative regulator of DEPP. Northern blot, in vitro insulin treatment of multiple cell lines, in vivo fasting/refeeding experiments, streptozotocin-induced diabetic mouse model Hormone and metabolic research Medium 19937567
2018 DEPP overexpression in HCT116 colon cancer cells promotes MAPK (ERK, JNK, p38) phosphorylation and upregulates Gadd45a; DEPP or Gadd45a knockdown impairs baicalein-induced apoptosis, caspase-3/9 activation, and MAPK phosphorylation; JNK/p38 inhibition decreases Gadd45a expression, establishing a DEPP→MAPK→Gadd45a positive feedback loop leading to apoptosis. siRNA knockdown of DEPP and Gadd45a, Annexin V/PI apoptosis assay, caspase activity assay, Western blot for phospho-MAPKs, kinase inhibitors (SP600125, SB203580, SCH772984) International journal of oncology Medium 29749481
2022 DEPP activates mitochondrial autophagy (mitophagy) in chondrocytes via BCL2 interacting protein 3 (BNIP3); DEPP is downstream of FOXO transcription factors in chondrocytes; DEPP knockout mice show exacerbated cartilage degradation with decreased autophagic flux and increased chondrocyte death, establishing DEPP as a stress-inducible regulator of mitophagy in osteoarthritis. DEPP knockdown/overexpression in chondrocytes, autophagic flux measurement, FOXO knockdown, subcellular fractionation, DEPP-knockout mice (destabilization of medial meniscus OA model), TUNEL assay FASEB journal High 34997944
2024 DEPP1 is induced by HIF (hypoxia-inducible factor) under hypoxia in cardiomyocytes; DEPP1 localizes inside mitochondria; DEPP1 is both necessary and sufficient for hypoxia-induced autophagy and triglyceride accumulation in cardiomyocytes; whole-body Depp1 knockout decreases cardiac dysfunction in mice with chronic HIF activation (VHL cardiac knockout), establishing DEPP1 as a key HIF-downstream mediator of ischemic cardiomyopathy features. CRISPR-Cas9 Depp1 knockout mice, cardiac pVHL-knockout mice, RNA sequencing, immunoblot, mitochondrial and peroxisomal autophagy flux measurements, live-cell imaging of isolated cardiomyocytes Circulation High 38881449

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 An extreme case of plant-insect codiversification: figs and fig-pollinating wasps. Systematic biology 182 22848088
2003 Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes, chromosomes & cancer 171 12661006
2017 Regulation of Fig (Ficus carica L.) Fruit Color: Metabolomic and Transcriptomic Analyses of the Flavonoid Biosynthetic Pathway. Frontiers in plant science 139 29209349
2018 Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling. Cell death & disease 96 29440765
2020 Genomes of the Banyan Tree and Pollinator Wasp Provide Insights into Fig-Wasp Coevolution. Cell 94 33035453
2001 Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation. Journal of natural products 88 11473446
2013 Obligate mutualism within a host drives the extreme specialization of a fig wasp genome. Genome biology 85 24359812
2017 C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy. Molecular cancer 82 28545464
2001 Molecular phylogenies of fig wasps: partial cocladogenesis of pollinators and parasites. Molecular phylogenetics and evolution 72 11603937
2013 Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target. Proceedings of the National Academy of Sciences of the United States of America 65 24154728
2009 Complete nucleotide sequence of four RNA segments of fig mosaic virus. Archives of virology 58 19777155
2004 Correlated evolution in fig pollination. Systematic biology 51 14965908
2018 Baicalein induces the apoptosis of HCT116 human colon cancer cells via the upregulation of DEPP/Gadd45a and activation of MAPKs. International journal of oncology 50 29749481
2014 C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma. Molecular cancer 48 25261981
2023 DePolymerase Predictor (DePP): a machine learning tool for the targeted identification of phage depolymerases. BMC bioinformatics 47 37208612
2007 Host-specificity and coevolution among pollinating and nonpollinating New World fig wasps. Molecular ecology 46 17444902
1995 Novel Ti plasmids in Agrobacterium strains isolated from fig tree and chrysanthemum tumors and their opinelike molecules. Molecular plant-microbe interactions : MPMI 46 7756696
2012 Wolbachia infection and dramatic intraspecific mitochondrial DNA divergence in a fig wasp. Evolution; international journal of organic evolution 45 22671555
2012 An integrated badnavirus is prevalent in fig germplasm. Phytopathology 44 22992110
2001 Phylogenetic relationships of fig wasps pollinating functionally dioecious Ficus based on mitochondrial DNA sequences and morphology. Systematic biology 39 12116930
2020 Epigenetic patterns within the haplotype phased fig (Ficus carica L.) genome. The Plant journal : for cell and molecular biology 38 31808196
2021 Genome-Wide Characterization and Analysis of bHLH Transcription Factors Related to Anthocyanin Biosynthesis in Fig (Ficus carica L.). Frontiers in plant science 35 34691109
2016 Pollinator sharing and gene flow among closely related sympatric dioecious fig taxa. Proceedings. Biological sciences 35 27075252
2020 Genetic Diversity and Thermal Performance in Invasive and Native Populations of African Fig Flies. Molecular biology and evolution 34 32109281
2014 The c10orf10 gene product is a new link between oxidative stress and autophagy. Biochimica et biophysica acta 34 24530860
2007 Cytotoxicity of fig fruit latex against human cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 32 18078703
2008 Correlated evolution of fig size and color supports the dispersal syndromes hypothesis. Oecologia 31 18386067
2005 A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor. Molecular human reproduction 31 16123073
2019 Nutritional, chemical and bioactive profiles of different parts of a Portuguese common fig (Ficus carica L.) variety. Food research international (Ottawa, Ont.) 28 31732029
2021 Fig fruit ripening is regulated by the interaction between ethylene and abscisic acid. Journal of integrative plant biology 27 33421307
2015 Synergistic Effects of Crizotinib and Temozolomide in Experimental FIG-ROS1 Fusion-Positive Glioblastoma. Cancer growth and metastasis 27 26648752
2023 DEPP: Deep Learning Enables Extending Species Trees using Single Genes. Systematic biology 26 35485976
2013 Diel variation in fig volatiles across syconium development: making sense of scents. Journal of chemical ecology 26 23609162
2009 Partial Sequence and Survey Analysis Identify a Multipartite, Negative-Sense RNA Virus Associated with Fig Mosaic. Plant disease 26 30764262
2013 Evolution and expression plasticity of opsin genes in a fig pollinator, Ceratosolen solmsi. PloS one 24 23342036
2014 Screening for the FIG-ROS1 fusion in biliary tract carcinomas by nested PCR. Genes, chromosomes & cancer 23 25231053
2014 Nucleocapsid protein from fig mosaic virus forms cytoplasmic agglomerates that are hauled by endoplasmic reticulum streaming. Journal of virology 23 25320328
2022 C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22 34997944
2011 FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells. FEBS letters 22 21510935
2019 Cytokinin-induced parthenocarpy of San Pedro type fig (Ficus carica L.) main crop: explained by phytohormone assay and transcriptomic network comparison. Plant molecular biology 21 30656555
2019 ROS1-GOPC/FIG: a novel gene fusion in hepatic angiosarcoma. Oncotarget 21 30719217
2021 Metabolome and transcriptome analysis of flavor components and flavonoid biosynthesis in fig female flower tissues (Ficus carica L.) after bagging. BMC plant biology 20 34433422
2019 A Possible Mechanism: Genistein Improves Metabolism and Induces White Fat Browning Through Modulating Hypothalamic Expression of Ucn3, Depp, and Stc1. Frontiers in endocrinology 20 31379744
2010 Molecular approaches to identify cryptic species and polymorphic species within a complex community of fig wasps. PloS one 19 21124735
2022 Genome-wide analysis of JAZ family genes expression patterns during fig (Ficus carica L.) fruit development and in response to hormone treatment. BMC genomics 18 35236292
2020 Characterization of terpene synthase genes potentially involved in black fig fly (Silba adipata) interactions with Ficus carica. Plant science : an international journal of experimental plant biology 18 32771161
2014 Odorant-binding protein (OBP) genes affect host specificity in a fig-pollinator mutualistic system. Insect molecular biology 18 25039747
2020 Ethephon induces coordinated ripening acceleration and divergent coloration responses in fig (Ficus carica L.) flowers and receptacles. Plant molecular biology 17 33185823
2019 Differential color development and response to light deprivation of fig (Ficus carica L.) syconia peel and female flower tissues: transcriptome elucidation. BMC plant biology 17 31122203
2017 Novel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor. Journal of neurosurgery. Pediatrics 17 28387643
2009 Insulin-mediated regulation of decidual protein induced by progesterone (DEPP) in adipose tissue and liver. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 17 19937567
2000 Cloning and expression of an acidic pectin methylesterase from jelly fig (Ficus awkeotsang). Journal of agricultural and food chemistry 17 10898664
2022 Fig latex inhibits the growth of pathogenic bacteria invading human diabetic wounds and accelerates wound closure in diabetic mice. Scientific reports 16 36528674
2019 The distinct ripening processes in the reproductive and non-reproductive parts of the fig syconium are driven by ABA. Journal of experimental botany 16 30239815
2019 Proteome and transcriptome analyses reveal key molecular differences between quality parameters of commercial-ripe and tree-ripe fig (Ficus carica L.). BMC plant biology 16 30991947
2018 DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS-induced FGF21. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16 29702025
2013 Contrasting genetic responses to population fragmentation in a coevolving fig and fig wasp across a mainland-island archipelago. Molecular ecology 16 23879300
2011 The complete nucleotide sequence and genome organization of Fig cryptic virus, a novel bipartite dsRNA virus infecting fig, widely distributed in the Mediterranean basin. Virus genes 16 21318240
2020 The Effects of Silver Nanoparticles Biosynthesized Using Fig and Olive Extracts on Cutaneous leishmaniasis Induced Inflammation in Female Balb/c Mice. Bioscience reports 15 33252120
2015 Metatranscriptome Analysis of Fig Flowers Provides Insights into Potential Mechanisms for Mutualism Stability and Gall Induction. PloS one 15 26090817
2006 Microsporogenesis in Brachiaria dictyoneura (Fig. & De Not.) Stapf (Poaceae: Paniceae). Genetics and molecular research : GMR 15 17183491
2021 Genome characterization of fig umbra-like virus. Virus genes 14 34524603
2021 Moderate Salinity Stress Affects Expression of Main Sugar Metabolism and Transport Genes and Soluble Carbohydrate Content in Ripe Fig Fruits (Ficus carica L. cv. Dottato). Plants (Basel, Switzerland) 14 34579394
2021 Novel Symbiotic Association Between Euwallacea Ambrosia Beetle and Fusarium Fungus on Fig Trees in Japan. Frontiers in microbiology 14 34650529
2020 Carboxylated nanodiamond-mediated NH2-PLGA nanoparticle-encapsulated fig polysaccharides for strongly enhanced immune responses in vitro and in vivo. International journal of biological macromolecules 14 33045302
2016 Tissue-Specific Transcriptome and Hormonal Regulation of Pollinated and Parthenocarpic Fig (Ficus carica L.) Fruit Suggest that Fruit Ripening Is Coordinated by the Reproductive Part of the Syconium. Frontiers in plant science 14 27965676
2014 Competitive exclusion among fig wasps achieved via entrainment of host plant flowering phenology. PloS one 14 24849458
2010 Identification, mycotoxin risk and pathogenicity of Fusarium species associated with fig endosepsis in Apulia, Italy. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 14 20352549
2021 DNA Modification Patterns within the Transposable Elements of the Fig (Ficus carica L.) Genome. Plants (Basel, Switzerland) 13 33673593
2018 Transcriptome analysis unravels spatiotemporal modulation of phytohormone-pathway expression underlying gibberellin-induced parthenocarpic fruit set in San Pedro-type fig (Ficus carica L.). BMC plant biology 13 29859043
2024 Preparation and characterization of a jelly fig (Ficus awkeotsang Makino) polysaccharide-based bioactive 3D scaffold for improved vascularization and skin tissue engineering applications. International journal of biological macromolecules 12 38176487
2023 Polygalacturonase gene family analysis identifies FcPG12 as a key player in fig (Ficus carica L.) fruit softening. BMC plant biology 12 37316788
2023 Comparative Analysis of the Immune Response and the Clinical Allergic Reaction to Papain-like Cysteine Proteases from Fig, Kiwifruit, Papaya, Pineapple and Mites in an Italian Population. Foods (Basel, Switzerland) 12 37569122
2021 Genomes of 12 fig wasps provide insights into the adaptation of pollinators to fig syconia. Journal of genetics and genomics = Yi chuan xue bao 12 34011484
2018 Comparison and Assessment of Flixweed and Fig Effects on Irritable Bowel Syndrome with Predominant Constipation: A Single-Blind Randomized Clinical Trial. Explore (New York, N.Y.) 12 30318190
2020 Tracking the Distribution and Burst of Nuclear Mitochondrial DNA Sequences (NUMTs) in Fig Wasp Genomes. Insects 11 33036463
2020 Effects of waste fig seed powder on quality as an innovative ingredient in biscuit formulation. Journal of food science 11 33295015
2019 The nature of interspecific interactions and co-diversification patterns, as illustrated by the fig microcosm. The New phytologist 11 31494940
2018 Isolation and Evaluation of New Antagonist Bacillus Strains for the Control of Pathogenic and Mycotoxigenic Fungi of Fig Orchards. Applied biochemistry and biotechnology 11 29721823
2024 Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy. Circulation 10 38881449
2023 AGEs Blocker™ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice. Preventive nutrition and food science 10 37416794
2018 High-Throughput Sequencing Reveals Cyclamen persicum Mill. as a Natural Host for Fig Mosaic Virus. Viruses 10 30513865
2020 Low-coverage genomic data resolve the population divergence and gene flow history of an Australian rain forest fig wasp. Molecular ecology 9 32567765
2011 Surveillance study of hepatitis A virus RNA on fig and date samples. Applied and environmental microbiology 9 22138987
2010 Molecular phylogenies of figs and fig-pollinating wasps in the Ryukyu and Bonin (Ogasawara) islands, Japan. Genes & genetic systems 9 21041977
2021 Physiological and molecular responses for long term salinity stress in common fig (Ficus carica L.). Physiology and molecular biology of plants : an international journal of functional plant biology 8 33627966
2020 Broad range of substrate specificities in papain and fig latex enzymes preparations improve enumeration of Listeria monocytogenes. International journal of food microbiology 8 32911158
2011 Antioxidant activity of a Mediterranean food product: "fig syrup". Nutrients 8 22254099
2022 Jelly Fig (Ficus awkeotsang Makino) Exhibits Antioxidative and Anti-Inflammatory Activities by Regulating Reactive Oxygen Species Production via NFκB Signaling Pathway. Antioxidants (Basel, Switzerland) 7 35624846
2022 Olfactory and gustatory receptor genes in fig wasps: Evolutionary insights from comparative studies. Gene 7 36243214
2021 Gene duplication and subsequent functional diversification of maltase in fig wasp (Chalcidoidea, Hymenoptera). International journal of biological macromolecules 7 33838190
2020 Evolution of Oxidative Phosphorylation (OXPHOS) Genes Reflecting the Evolutionary and Life Histories of Fig Wasps (Hymenoptera, Chalcidoidea). Genes 7 33203150
2019 Solubility Difference between Pectic Fractions from Creeping Fig Seeds. Polymers 7 30960143
2019 Generation and molecular docking analysis of specific single-chain variable fragments selected by phage display against the recombinant nucleocapsid protein of fig mosaic virus. Journal of virological methods 7 31812630
2018 Production of a polyclonal antiserum against recombinant nucleocapsid protein and its application for the detection of fig mosaic virus. Journal of virological methods 7 30579922
2016 Chlorophyll metabolism in pollinated vs. parthenocarpic fig fruits throughout development and ripening. Planta 7 27097639
2015 Papain Induced Occupational Asthma with Kiwi and Fig Allergy. Allergy, asthma & immunology research 7 26739411
2022 A chromosome-level genome assembly of the pollinating fig wasp Valisia javana. DNA research : an international journal for rapid publication of reports on genes and genomes 6 35595238
2022 AP2/ERF genes associated with superfast fig (Ficus carica L.) fruit ripening. Frontiers in plant science 6 36388580
2007 Purification, cloning, and identification of two thaumatin-like protein isoforms in jelly fig (Ficus awkeotsang) Achenes. Journal of agricultural and food chemistry 6 17691807