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Showing SRRM2 — CWC21 is a alias.

SRRM2

Serine/arginine repetitive matrix protein 2 · UniProt Q9UQ35

Length
2752 aa
Mass
299.6 kDa
Annotated
2026-06-10
31 papers in source corpus 16 papers cited in narrative 22 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SRRM2 is a large serine/arginine-rich nuclear protein that serves, together with SON, as a core structural scaffold of nuclear speckles, where its intrinsically disordered RS domains drive liquid-liquid phase separation through homotypic oligomerization and non-selective heterotypic protein-RNA coacervation (PMID:33095160, PMID:35929045, PMID:38381607). SON and SRRM2 form immiscible multiphases that subcompartmentalize speckles and independently regulate distinct alternative splicing programs, with serine residues within the RS domains specifically tuning condensate liquidity (PMID:38381607). As a splicing factor, SRRM2 docks directly to the core U5 snRNP proteins Prp8 and Snu114 at the spliceosome catalytic center—a function conserved from its yeast ortholog Cwc21p, which acts at or before the first catalytic step and contributes to splicing fidelity through interaction with Isy1p (PMID:19854871, PMID:19789211); it cooperates with cactin and DHX8 for efficient splicing of thousands of transcripts and for sister chromatid cohesion (PMID:28062851). SRRM2 promotes inclusion of cassette exons bearing short introns and weak splice sites and shapes specific isoform programs, including FES, MUC1, SynGAP, and AGAP3 (PMID:35929045, PMID:42189682), and in colorectal cancer it activates mTOR-S6K signaling by splicing-dependent control of S6K2 and by stabilizing S6K1 via the E3 ligase WWP2 (PMID:39956864). SRRM2 couples cellular state to splicing: nuclear arginyl-tRNA synthetase associates with SRRM2 to link arginine availability to splice-site usage (PMID:37059883), and SRRM2-dependent speckle reorganization sustains senescence and pluripotency-associated splicing programs (PMID:38656788). A germline S346F variant increases exon inclusion in carriers (PMID:26135620), and pathological tau drives mislocalization of SRRM2 from nuclear speckles into cytoplasmic neurofibrillary tangles in Alzheimer's disease, linking speckle disruption to impaired RNA processing in tauopathy (PMID:34187600).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2000 Low

    Initial cloning established SRRM2 as an RNA-associated protein with a unique RNA-binding region and two large phosphorylation-rich RS domains, defining the architecture that would later prove central to its function.

    Evidence cDNA cloning and sequence analysis as an ATBF1 mRNA 5'-UTR binding protein (SRL300) in human and rat cells

    PMID:11004489

    Open questions at the time
    • No functional follow-up of the ATBF1 mRNA interaction
    • RS domain function not tested
  2. 2003 Medium

    Early interaction screens placed SRRM2 in nuclear-speckle multiprotein complexes and connected it to viral transcriptional control, hinting at a broad role in nuclear gene-expression machinery.

    Evidence Yeast two-hybrid and co-IP with Pinin and SR-rich proteins in corneal/HEK cells; co-IP, reporter, and siRNA showing coactivation of HTLV-1 Tax transactivation

    PMID:12941912 PMID:14578391

    Open questions at the time
    • Mechanism linking complex membership to splicing not defined
    • Tax coactivation pathway not connected to speckle scaffolding
  3. 2009 High

    Yeast genetics resolved how SRRM2 engages the splicing machinery, showing its ortholog docks directly onto core U5 snRNP proteins at the spliceosome catalytic center and acts at the first catalytic step.

    Evidence Direct binding/cross-linking, genetic epistasis, and TAP-MS in S. cerevisiae Cwc21p, with demonstrated human SRm300 orthology; interactions with Prp8p, Snu114p, and Isy1p

    PMID:19789211 PMID:19854871

    Open questions at the time
    • Human SRRM2 docking inferred by orthology, not directly mapped structurally in human spliceosome
    • Catalytic contribution vs. scaffolding not separated
  4. 2013 Medium

    Work in C. elegans suggested SRRM2 is recruited to chromatin co-transcriptionally and influences RNA Pol II, expanding its role beyond the spliceosome to the transcription interface.

    Evidence RNAi, genetic epistasis, ChIP-Seq, and co-IP with RNAPII for the ortholog RSR-2

    PMID:23754964

    Open questions at the time
    • Splicing-independent chromatin role not confirmed in human SRRM2
    • Mechanism of RNAPII phosphorylation modulation unknown
  5. 2017 Medium

    Identification of the cactin-SRRM2-DHX8 complex linked SRRM2 splicing activity to a concrete cell-biological outcome—efficient sororin splicing and sister chromatid cohesion.

    Evidence Co-IP, siRNA depletion, RNA-seq, and chromosome segregation assays in human cells

    PMID:28062851

    Open questions at the time
    • Direct vs. indirect SRRM2-cactin contact not resolved
    • Single lab
  6. 2020 High

    Reciprocal genetic depletion established SRRM2 and SON as the essential dual scaffold of nuclear speckles and corrected the long-standing misattribution of the SC35 marker, reframing SRRM2 as a structural organizer.

    Evidence siRNA co-depletion, CRISPR IDR deletion, immunofluorescence, immunoblot, proteomics; plus ESC Srrm2 heterozygosity transcriptomics showing splicing-first then expression effects

    PMID:33095160 PMID:38656788

    Open questions at the time
    • IDR sequence features driving scaffolding not fully dissected at this stage
    • Relationship between scaffold role and individual splicing targets unresolved
  7. 2024 High

    In vitro reconstitution and domain swaps defined the biophysical basis of speckle organization, showing SRRM2 and SON form immiscible multiphases and that RS-domain serines fine-tune condensate liquidity while controlling distinct splicing targets.

    Evidence Super-resolution imaging, FRAP, in vitro phase separation, domain swap/mutagenesis, and RNA-seq

    PMID:38381607

    Open questions at the time
    • RNA species driving heterotypic coacervation not identified
    • How liquidity tuning maps to specific splice choices unclear
  8. 2023 Medium

    Coupling of SRRM2 to nuclear arginyl-tRNA synthetase showed metabolic state (arginine availability) can be transduced into altered splice-site usage, giving SRRM2 a signal-integration role.

    Evidence Co-IP, co-localization imaging, arginine depletion, RNA-seq splice-site analysis, and immunopeptidome assays

    PMID:37059883

    Open questions at the time
    • Mechanism by which ArgRS alters SRRM2 condensate behavior not defined
    • Direct vs. indirect functional coupling unresolved
  9. 2025 Medium

    Loss-of-function models tied SRRM2 dosage to specific neural splicing programs and to oncogenic signaling, defining concrete downstream effectors of SRRM2-dependent splicing.

    Evidence Srrm2+/- mice with snRNA-seq/proteomics validated in human iPSC neurons (SynGAP, Agap3, myelin); CRC SRRM2 perturbation linking S6K2 splicing and WWP2-mediated S6K1 stabilization to mTOR-S6K

    PMID:39956864 PMID:42189682

    Open questions at the time
    • Whether neural and cancer programs share a common splicing logic unknown
    • Direct WWP2 regulation mechanism not detailed
  10. 2025 Medium

    Disease-linked findings connected SRRM2 dysfunction to neurodegeneration through speckle disruption, including tau-driven cytoplasmic mislocalization and a familial ALS mutation that severs the SRRM2-ACIN1 interaction.

    Evidence IHC/IF in AD tissue and tauopathy mice; endogenous ALS point-mutation knock-in with co-IP (loss of ACIN1) and RNA-seq (preprint)

    PMID:34187600

    Open questions at the time
    • Causal direction between speckle disruption and tau pathology not fully established
    • ALS finding is a single-lab preprint awaiting peer review

Open questions

Synthesis pass · forward-looking unresolved questions
  • How upstream kinases and small-molecule cofactors regulate SRRM2 condensate state, and how that regulation selects specific splicing outcomes across tissues, remains unresolved.
  • No direct kinase assay on SRRM2 demonstrated
  • Quantitative link between phosphorylation state and target selection missing
  • Generalizability across cell types untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 3 GO:0005198 structural molecule activity 3 GO:0060090 molecular adaptor activity 2 GO:0140110 transcription regulator activity 1
Localization
GO:0005634 nucleus 3 GO:0005654 nucleoplasm 3
Pathway
R-HSA-8953854 Metabolism of RNA 3 R-HSA-74160 Gene expression (Transcription) 2 R-HSA-1640170 Cell Cycle 1
Partners
ACIN1CACTINISY1PININPRPF8RARSSNRNP200SON
Complex memberships
cactin-SRRM2-DHX8 complexnuclear specklespliceosome (NTC-related/U5 snRNP-associated)

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2020 SON and SRRM2 form the core scaffold of nuclear speckles: depletion of SON alone causes partial disassembly, but co-depletion of SON and SRRM2, or depletion of SON in cells where SRRM2's intrinsically disordered regions (IDRs) are genetically deleted, causes near-complete dissolution of nuclear speckles. The SC35 monoclonal antibody, widely used as a nuclear speckle marker, was found to principally recognize SRRM2, not SRSF2. siRNA co-depletion, CRISPR-mediated IDR deletion, immunofluorescence, immunoblot, proteomics eLife High 33095160
2022 SRRM2 forms biomolecular condensates consistent with liquid-liquid phase separation (spherical shape, dynamic rearrangement, coalescence, concentration dependence confirmed in vitro). SRRM2 organizes nuclear speckles throughout the cell cycle. SRRM2 deficiency causes skipping of cassette exons with short introns and weak splice sites. In THP-1 myeloid-like cells, SRRM2 depletion compromises cell viability, upregulates differentiation markers, and sensitizes cells to anti-leukemia drugs. SRRM2 induces a FES splice isoform that attenuates innate inflammatory responses and MUC1 isoforms with oncogenic shedding properties. EGFP-SRRM2 knock-in HEK293T cells, live-cell imaging, in vitro phase separation assay, RNA-seq after SRRM2 depletion, cell viability assays, drug sensitivity assays Nucleic acids research High 35929045
2024 SRRM2 and SON form immiscible multiphases within nuclear speckles and are functionally independent, each regulating distinct subsets of alternative splicing targets. SRRM2 drives nuclear speckle subcompartmentalization via homotypic interaction (through RS domain oligomerization) and heterotypic non-selective protein-RNA coacervation-driven phase separation. Serine residues within the RS domains play an irreplaceable role in fine-tuning nuclear speckle liquidity; RS domains can be functionally replaced by synthetic oligomerizable modules for structural but not liquidity roles. Super-resolution imaging, FRAP, in vitro phase separation, domain swap/mutagenesis, RNA-seq, cell-based condensate assays Cell reports High 38381607
2009 Yeast Cwc21p (ortholog of human SRm300/SRRM2) binds directly to two core spliceosomal proteins, Prp8p and Snu114p (U5 snRNP), making it the first NTC-related protein known to dock directly to U5 snRNP proteins. The conserved cwf21 domain in Cwc21p is the Prp8p binding site. Cwc21p and Isy1p have related functions at or prior to the first catalytic step of splicing. Human SRm300/SRRM2 is a functional ortholog of Cwc21p, also directly interacting with Prp8p and Snu114p. Direct binding assays, chemical cross-linking, proteomic analysis of the SCwid domain, genetic interaction (suppressor/synthetic lethality), co-immunoprecipitation RNA (New York, N.Y.) High 19854871
2009 Yeast Cwc21p (ortholog of SRm300/SRRM2) shows strong genetic, physical, and functional interactions with Isy1p (implicated in the first catalytic step of splicing and splicing fidelity), and associates with spliceosomal complexes, supporting a role for Cwc21/SRm300 in spliceosome activation and splicing fidelity. Quantitative genetic interaction mapping, tandem affinity purification mass spectrometry, microarray profiling RNA (New York, N.Y.) Medium 19789211
2003 SRRM2 (SRm300) physically interacts with Pinin (Pnn/DRS/memA) at the C-terminus of Pinin, and co-immunoprecipitates and co-localizes with Pinin and other SR-rich proteins (SRp75, SRrp130) in nuclear speckles in corneal epithelial cells, suggesting participation in a multiprotein nuclear complex involved in pre-mRNA processing. Yeast two-hybrid, co-immunoprecipitation, co-transfection with immunostaining in HCE-T and HEK-293 cells Investigative ophthalmology & visual science Medium 14578391
2003 SRRM2 (as TAXREB803/SRL300) interacts with HTLV-1 Tax oncoprotein, co-immunoprecipitates with Tax, co-localizes with Tax by indirect immunofluorescence, enhances Tax-dependent transcription and CREB binding to TxRE. Knockdown of TAXREB803 by siRNA dramatically decreases Tax transactivation of the HTLV-1 LTR, identifying SRRM2 as a transcriptional coactivator for Tax. Co-immunoprecipitation, indirect immunofluorescence, luciferase reporter assay, siRNA knockdown Journal of virology Medium 12941912
2013 RSR-2, the C. elegans ortholog of SRm300/SRRM2, is essential for viability and acts within the germline sex determination pathway (genetic epistasis). RSR-2 colocalizes with DNA in germline nuclei and co-precipitates with chromatin, with a ChIP-Seq profile similar to RNA Polymerase II. RSR-2 recruitment to chromatin is splicing-independent. RSR-2 interacts with RNAPII and affects RNAPII phosphorylation states. Strongest interacting partners identified by proteomics are PRP-8 and PRP-19. RNAi, genetic epistasis analysis, transcriptomics, ChIP-Seq, co-immunoprecipitation with RNAPII, proteomic analysis PLoS genetics Medium 23754964
2017 Human cactin physically and functionally interacts with SRRM2 (co-immunoprecipitation), and this complex (along with DHX8) is required for efficient pre-mRNA splicing of thousands of transcripts and for sister chromatid cohesion. Cactin depletion impairs splicing of sororin (CDCA5) pre-mRNA, causing premature sister chromatid separation. Co-immunoprecipitation, siRNA depletion, RNA-seq splicing analysis, cell biology (chromosome segregation assay) Journal of cell science Medium 28062851
2023 Nuclear arginyl-tRNA synthetase (ArgRS) interacts and co-localizes with SRRM2. During arginine depletion (as occurs in inflammation), nuclear ArgRS levels decrease, which correlates with changes in condensate-like nuclear trafficking of SRRM2 and altered splice-site usage in specific genes, leading to different protein isoforms that alter cellular metabolism and peptide presentation to immune cells. Co-immunoprecipitation, co-localization by imaging, arginine depletion experiments, RNA-seq splice site analysis, metabolic and immunopeptidome assays Nature cell biology Medium 37059883
2015 The germline missense variant S346F in SRRM2 causes a higher ratio of exon inclusion in leukocytes of carriers compared to controls (RNA-seq and experimental validation of 7 exons), consistent with altered alternative splicing activity of SRRM2 due to this mutation. RNA-seq in human leukocytes from variant carriers vs. controls, experimental validation of specific exon inclusion events by RT-PCR Scientific reports Medium 26135620
2000 SRL300 (SRRM2) protein was cloned as a binding protein for the 5'-noncoding sequence of ATBF1 mRNA; it contains a unique RNA-binding region and two large RS domains with multiple phosphorylation sites, and is detected in both human and rat cells. cDNA cloning, sequence analysis, immunodetection in human and rat cells Biochimica et biophysica acta Low 11004489
2021 SRRM2, normally a nuclear speckle scaffold protein, is mislocalized to cytoplasmic lesions (neurofibrillary tangles) in Alzheimer's disease brain tissue and in transgenic tauopathy mice, with mislocalization severity correlating with pathological tau deposition. This identifies pathological tau as a driver of ectopic cytoplasmic accumulation of SRRM2. Immunohistochemistry and immunofluorescence in human AD tissue and transgenic mouse brain, correlation with tau pathology staging Acta neuropathologica communications Medium 34187600
2025 A point mutation in SRRM2 associated with familial ALS causes loss of the protein-protein interaction between SRRM2 and the splicing factor ACIN1, and leads to widespread differential gene expression converging on dysregulation of synapse-associated pathways in a model cell line carrying the endogenous point mutation. Endogenous point mutation knock-in, co-immunoprecipitation (loss of ACIN1 interaction), transcriptomics (RNA-seq) bioRxivpreprint Medium
2025 SRRM2 is a substrate/target of the nuclear speckle-localized kinase TAOK2: biochemical phosphoproteomics identifies SRRM2 (and SRRM1) as potential direct phosphorylation targets of TAOK2. TAOK2 knockdown perturbs speckle-resident SR proteins (including SRRM2-containing speckles) while leaving hnRNPs unperturbed, suggesting that TAOK2-mediated phosphorylation of SRRM2 plays a structural maintenance role at nuclear speckles. siRNA knockdown, cellular and biochemical phosphoproteomics, splicing and nuclear export transcriptomics, imaging of nuclear speckle integrity bioRxivpreprint Low
2025 Polyphosphate (polyP) directly interacts with SRRM2 (the NS core component), and polyP depletion disrupts nuclear speckle organization. Mechanistically, polyP acts as a physiological inhibitor of CLK3 kinase, preventing phosphorylation of SR proteins and thereby maintaining nuclear speckle stability. BAR (Biotinylation by Antibody Recognition) proximity labeling, polyP depletion experiments, imaging of nuclear speckle integrity, RNA-seq, CLK3 kinase inhibition assay bioRxivpreprint Low
2024 In senescent cells, SRRM2 is repurposed to cluster CTCF into senescence-induced clusters (SICCs) at nuclear speckles, together with BANF1. The RNA-binding domain of SRRM2 directs CTCF clustering, and SICC disruption fully reverts senescence-associated alternative splicing patterns, demonstrating that SRRM2-mediated nuclear speckle reorganization sustains the senescence splicing program. Functional assays, super-resolution imaging, 3D genomics, computational modelling, domain deletion (SRRM2 RNA-binding domain) bioRxivpreprint Low
2025 Srrm2 haploinsufficiency in mice causes splicing dysregulation including reduction of SynGAP-γ isoform and mis-splicing of Agap3, reduced oligodendrocyte proportions in striatum, and decreased myelin-related gene expression. These AGAP3 splicing defects are conserved in human iPSC-derived neurons deficient in SRRM2. Srrm2+/- mouse model, single-nucleus RNA-seq, proteomics, human iPSC-derived neurons with SRRM2 depletion, EEG, behavioral assays Cell reports Medium 42189682
2025 SRRM2 modulates levels of S6K1 and S6K2 to activate the mTOR-S6K pathway in colorectal cancer: SRRM2 facilitates S6K2 expression by modulating alternative splicing, and enhances S6K1 protein stability by regulating the E3 ubiquitin ligase WWP2. SRRM2 knockdown/overexpression, alternative splicing analysis (RNA-seq), protein stability assays, ubiquitin ligase regulation assays, in vitro and in vivo CRC growth assays Oncogene Medium 39956864
2024 The intrinsically disordered region (IDR) of SRRM2 is required for enlarging nuclear speckles in the presence of HIV capsid, and HIV-induced CPSF6 puncta fuse with nuclear speckles via the IDR of SRRM2. Genetic manipulation and depletion of SRRM2 IDR, live-cell imaging of CPSF6 puncta/speckle fusion, domain deletion experiments bioRxivpreprint Low
2024 Disruption of nuclear speckle integrity through SRRM2 downregulation promotes TDP-43 mislocalization from the nucleus and loss of TDP-43 splicing function. siRNA knockdown of SRRM2, TDP-43 localization imaging, cryptic exon splicing assays bioRxivpreprint Low
2020 Srrm2 heterozygosity in embryonic stem cells induces loss of stemness, with coexistence of naive and formative pluripotency markers and changes in expression of SRF-regulated and differentiation-related genes. The earliest effects of Srrm2 heterozygosity are specific alternative splicing events on a small number of genes, followed by broader gene expression changes. Srrm2 heterozygous mouse ESC line, RNA interference, transcriptomics (RNA-seq), pluripotency marker immunofluorescence Biology open Medium 38656788

Source papers

Stage 0 corpus · 31 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 SON and SRRM2 are essential for nuclear speckle formation. eLife 204 33095160
2010 SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinson's disease. PloS one 95 20161708
2022 SRRM2 organizes splicing condensates to regulate alternative splicing. Nucleic acids research 90 35929045
2015 A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition. Scientific reports 80 26135620
2003 Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. Investigative ophthalmology & visual science 54 14578391
2021 Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease. Acta neuropathologica communications 53 34187600
2009 Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome. RNA (New York, N.Y.) 46 19854871
2022 Loss-of-function variants in SRRM2 cause a neurodevelopmental disorder. Genetics in medicine : official journal of the American College of Medical Genetics 39 35567594
2024 SRRM2 phase separation drives assembly of nuclear speckle subcompartments. Cell reports 38 38381607
2019 Silencing of long noncoding RNA SRRM2-AS exerts suppressive effects on angiogenesis in nasopharyngeal carcinoma via activating MYLK-mediated cGMP-PKG signaling pathway. Journal of cellular physiology 29 31742692
2009 A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300. RNA (New York, N.Y.) 29 19789211
2023 Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2. Nature cell biology 28 37059883
2020 A compound downregulation of SRRM2 and miR-27a-3p with upregulation of miR-27b-3p in PBMCs of Parkinson's patients is associated with the early stage onset of disease. PloS one 24 33171483
2017 Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion. Journal of cell science 21 28062851
2013 RSR-2, the Caenorhabditis elegans ortholog of human spliceosomal component SRm300/SRRM2, regulates development by influencing the transcriptional machinery. PLoS genetics 13 23754964
2000 Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains. Biochimica et biophysica acta 8 11004489
2003 SR-related protein TAXREB803/SRL300 is an important cellular factor for the transactivational function of human T-cell lymphotropic virus type 1 Tax. Journal of virology 7 12941912
2023 Familial and genetic association with neurodevelopmental disorders caused by a heterozygous variant in the SRRM2 gene. Frontiers in endocrinology 6 37621647
2023 A Palindrome-Like Structure on 16p13.3 Is Associated with the Formation of Complex Structural Variations and SRRM2 Haploinsufficiency. Human mutation 6 40225164
2024 SRRM2 may be a potential biomarker and immunotherapy target for multiple myeloma: a real-world study based on flow cytometry detection. Clinical and experimental medicine 5 38289482
2024 SRRM2 splicing factor modulates cell fate in early development. Biology open 5 38656788
2025 Rare SRRM2 mutation in neurodevelopmental disorders involving hyperphagia triggering severe obesity and other complication. Frontiers in medicine 4 40046925
2024 The Nuclear Speckles Protein SRRM2 Is Exposed on the Surface of Cancer Cells. Cells 4 39329747
2026 D e novo SRRM2 variants in neuroendocrine cell hyperplasia of infancy and persistent tachypnoea of infancy. The European respiratory journal 2 40967764
2025 The splicing factor SRRM2 modulates two S6K kinases to promote colorectal cancer growth. Oncogene 1 39956864
2025 LINC00426 promotes the progression of atherosclerosis by regulating miR-873-5p/SRRM2 axis. Cytokine 1 40233646
2025 Neurodevelopmental disorder and juvenile-onset tics associated with microdeletion of the SRRM2 gene. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 1 40545495
2022 Effect of GATAD1 regulating the SRRM2 gene on recurrence of thyroid tumor and its molecular mechanism. Gland surgery 1 36654960
2026 Long noncoding RNA SRRM2-AS1 mediates coronary artery damage in Kawasaki disease by promoting endothelial-to-mesenchymal transition. Clinical and experimental medicine 0 41731159
2026 Srrm2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a genetic mouse model of schizophrenia. Cell reports 0 42189682
2025 The impact of SRRM2-AS1 in ovarian cancer: a comprehensive analysis based on pan-cancer and in vitro validation. Discover oncology 0 40515981

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